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Murugesan Rajaram, PhD


460 W 12th Ave
Columbus, OH 43210

Phone: (614) 688-8024

Email: rajaram.3@osu.edu

 

Current OSU Appointment

Research Assistant Professor, SBS-Microbial Infectn/Immunity

 

Biographical

Our research program is focused on the host innate immunity against bacterial pathogenesis and how Mycobaterium tuberculosis subvert host innate immune response and become drug resistant. A primary focus of the lab establishes that M.tb drives the macrophages to become drug resistant by upregulating the expression of MDR-1 (a drug efflux pump) that lead to reduced exposure of inhaled M.tb to anti TB drugs. Low grade anti TB drug exposure helps the bacteria to develop drug resistant variants. Additionally our lab focus to understand the mechanism of M.tb mediated suppression of autophagy; a host protective mechanism involved in the elimination of invaded pathogens. Our work revealed that M.tb infection down regulates the expression of HSF1 a stress response transcription factor that lead to decreased production of heat shock proteins and subsequent accumulation of protein aggregates within the M.tb infected cells to inhibit the autophagy machinery. HSF1 activity is required for the expression of autophagy related genes and M.tb infection decreases the autophagy related genes Atg18, 7 and Beclin-1 in macrophages. A second line of work is the role of the miR155 mediated pathway in regulation of cardiac inflammation and heart failure. We have identified an instructive bacterial sepsis model to study the cardiac dysfunction in mice and discovered that miR155 function as a master regulator for initiation of cardiac intrinsic inflammatory pathways by targeting myopalladin and HSF1 that lead to cardiac remodeling and dysfunction.
I have published over 42 peer reviewed research articles relevant to the macrophage biology and signaling in response to various pathogens. I have extensively studied the pathogenesis of (M.tb) in the OSU BSL3 laboratory using human alveolar macrophages (hAMs), monocyte derived macrophages (MDMs), human monocytic cell lines, mouse bone marrow derived macrophages (BMDMs), peritoneal macrophages, mAMs and murine cell lines and the research findings have been published in many peer reviewed journals including Cell Reports, PNAS, PLOS Pathogens and Journal of Immunology. Also I have an excellent knowledge in microRNA biogenesis, target identification and validation, microRNA arrays, NanoString technology for human and murine microRNAs and manipulating the microRNA expressions in immune cells and mice. I have recently demonstrated the methodology to efficiently and effectively knockdown specific proteins in primary macrophages and other primary cells, and also have broad experience in animal models resulted in many peer reviewed publications in high end journals.

Recently, my research work was accepted for publication in Cell Reports, in which I am first and shared corresponding author.

Based google scholar my research publications was cited more than 1595
Citation indices&emspAll&emsp
Citations:1595&emsp
h-index:&emsp21&emsp
i10-index:&emsp29
&emsp
Since 2012
Citations: 1223
h-index : 20
i10-index: 27
https://scholar.google.com/citations?user=tpzBYocAAAAJ&hl=en

Research Funding

1.&emspTitle of project: Effect of miR155 and HSF-1 on cardiac dysfunction during bacterial sepsis
Period of funding: 01/01/2017 –12/30/2018
Authors in the order listed on the proposal: Murugesan Rajaram and PeterJ. Mohler
Source and total amount (direct and indirect) of funding: American Heart Association; Grant In Aid-$77,000 + 10% indirect.

2.&emspTitle of project: Role of miR155 and HSF-1 on cardiac inflammation and dysfunction in sepsis
Period of funding: 10/01/2016 –09/30/2018
Authors in the order listed on the proposal: Murugesan Rajaram and Peter J. Mohler
Source and total amount (direct and indirect) of funding: PHPID new investigator grant, The Ohio State University ; $50,000/year for 2 years.

3.Title of project: TB and Innate Immune Regulation of Lung Macrophages
Period of funding: 08-01-2012 to 07-31-2017
Authors in the order listed on the proposal: Dr. Larry S. Schlesinger, Murugesan Rajaram and Joanne Turner
Source and total amount (direct and indirect) of funding: NIH, NIAID R01 AI059639

4. Title of project: Exploring the impact of inflammaging on immune function during Mycobacterium tuberculosis infection- Project-2 Period of funding: 03/15/16-02/28/21
Authors in the order listed on the proposal: Dr. Larry S. Schlesinger, Murugesan Rajaram and William Lafuse
Source and total amount (direct and indirect) of funding: NIH, NIAID, P01 AG044298;

5.Title of project: Role of Protein Ubiquitination in Sepsis
Period of funding: 03/15/16-02/28/21
Authors in the order listed on the proposal: Dr. Jian Zhang, Murugesan Rajaram and Xiaokui Mo,
Source and total amount (direct and indirect) of funding: NIH, NIAID, R01;AI121196 $ 2,325,951

Noteworthy Graduate Narrative

Undergraduate Abbiagail Gerbercik, Presented her work in Denman undergraduate research forum in March 2017, and received a honor mention.

Published Works

I have published many high end journals Such as PNAS, PLOS Pathogen, Cell Reports and Nature Medicine. Among those my work published in Journal of Immunlogy about PPARg role in M.tb pathogenesis was highlights in JI.

Academic Advising

Since my appointment on September 2012, I have trained 3 undergraduate students, two graduate students as co-advisor, 2 post doctoral fellows.
Currently in my lab there are two undergraduate students (Abbigail Gerberick and Sumiran Mehta) are working on two different projects. I am advising them for their research.

Advising Narrative

Graduate student to whom I served as co-advisory Michelle Brooks, published two first and two second authors peer reviewed manuscript. She received best poster presentation award from DHLRI research day and OSUMC research day. Also her abstract we selected to present in three Key Stone Symposia meetings. NO she is a Adjunct Assistant Professor at University of Maryland and Staff Scientist at FDA.

Other graduate student to whom I served as co-adviser Bin Ni is a MD-PhD student, she completed her Ph.D with one first author publication and two middle author publications. Now she is a residence fellow in OSUMC.

I have trained two lab assistants, 1. Huy A. Nguyen, has published one first author manuscript in AJP and now he is a residence fellow at Cleveland Clinic. 2. Jessica Morris , worked on a project with me and the results were published in PNAS, She was a second author in that manuscript. Jessica finsihed her MD from The Ohio State University and doing her residency (ER) in Duke

Academic Advising

2013 Ky Hoang, OSU Center for Microbial Interface Biology CMIB. Graduated 0.
2004 - 2006 Ragu Kanagasabai, The Ohio State University. Graduated 0.
2008 - 2009 Jessica Morris, The Ohio State University.
2009 - 2010 Bret Betz, Ohio State University College of Medicine. Graduated 2012.
2008 - 2011 Michelle N., The Ohio State University. Graduated 2011.
2009 - 2011 Huy Nguyen, OSU Center for Microbial Interface Biology CMIB.
2012 Alaric W.D., Yale University. Graduated 0.
2011 - 2014 Daniel House, The Ohio State University.
2008 - 2015 Bin Ni, The Ohio State University.
2013 - 2017 Claire Dood, The Ohio State University.
 

Books

Tracy K Carlson, Michelle N Brooks, Douglas A. Meyer, Lisa Henning, Murugesan VS Rajaram and Larry S Schlesinger. Pulmonary innate immunity: Soluble and cellular host defenses of the lung. Trivandrum, India, IN|IND: Transworld Research Network, June 2010.

 

Chapters in Books

Tracy K.Carlosn, Michelle Brooks, Douglas A.Meyer, Lisa Henning, Murugesan V.S.Rajaram and Larry S.Schlesinger.. "Pulmonar innate immunity:Soluble and cellular host defenses of the lung.." In Regulation of Innate Immune Function. Edited by Clay B.Marsh, Susheela Tridandapani and Melissa G.Piper. 165-211. Trivandrum, IN|IND: Transworld Research Network, August 2012.

 

Degrees

2000 Ph.D., University Of Madras India

 

Editorial Activities

2013 - present PLOS ONE
2014 - present BMC Pulmonary Medicine
2015 - present Journal of Immunology
2015 - present Stem Cell Research and Therapy
2016 - present PLOS Pathogens
2016 Role of PPARgamma in disease
2017 - present Frontiers in Immunology
 

Honors

2010 First Prize In 2010 Research Poster presentation. Dorothy M. Davis Heart & Lung Research Institute.
2011 - present 1st prize 2011 Research Poster Competition. Dorothy M. Davis Heart & Lung research Institute.
2012 - present 2nd Place in 2012 Research poster competition. Dorothy M. Davis Heart & Lung Research Institute.
2014 Early Career Faculty Travel Grant. American Association of Immunology.
2015 Session Chair. American Association of Immunology.
2016 AAI Early Career Faculty Travel grant. Career Development and Oral presentation.
 

Journal Articles

N.Anand and Murugesan V.S. Rajaram. "Nitrogen fixation at night in nature. 70:119-120.." Current Science. Vol. 70, (October 1996.): 119-120..

Rajaram,Murugesan,VS; Ganesan,Latha,P; Parsa,Kishore,VL; Butchar,Jonathan,P; Gunn,John,S; Tridandapani,Susheela. "Akt/protein kinase B modulates macrophage inflammatory response to Francisella infection and confers a survival advantage in mice." JOURNAL OF IMMUNOLOGY. Vol. 177, no. 9. (November 2006.): 6317-6324.

Parsa,Kishore,VL; Ganesan,Latha,P; Rajaram,Murugesan,VS; Gavrilin,Mikhail,A; Balagopal,Ashwin; Mohapatra,Nrusingh,P; Wewers,Mark,D; Schlesinger,Larry,S; Gunn,John,S; Tridandapani,Susheela. "Macrophage pro-inflammatory response to Francisella novicida infection is regulated by SHIP." PLOS PATHOGENS. Vol. 2, no. 7. (July 2006.): 681-690.

Butchar,Jonathan,P; Rajaram,Murugesan,VS; Ganesan,Latha,P; Parsa,Kishore,VL; Clay,Corey,D; Schlesinger,Larry,S; Tridandapani,Susheela. "Francisella tularensis induces IL-23 production in human monocytes." JOURNAL OF IMMUNOLOGY. Vol. 178, no. 7. (April 2007.): 4445-4454.

Weir,Nathan,M; Selvendiran,Karuppaiyah; Kutala,Vijay,Kumar; Tong,Liyue; Vishwanath,Shilpa; Rajaram,Murugesan; Tridandapani,Susheela; Anant,Shrikant; Kuppusamy,Periannan. "Curcumin induces G2/M arrest and apoptosis in cisplatin-resistant human ovarian cancer cells by modulating Akt and p38 MAPK." CANCER BIOLOGY & THERAPY. Vol. 6, no. 2. (February 2007.): 178-184.

Parsa,Kishore,VL; Butchar,Jonathan,P; Rajaram,Murugesan,VS; Cremer,Thomas,J; Tridandapani,Susheela. "The tyrosine kinase Syk promotes phagocytosis of Francisella through the activation of Erk." MOLECULAR IMMUNOLOGY. Vol. 45, no. 10. (May 2008.): 3012-3021.

Parsa,Kishore,VL; Butchar,Jonathan,P; Rajaram,Murugesan,VS; Cremer,Thomas,J; Gunn,John,S; Schlesinger,Larry,S; Tridandapani,Susheela. "Francisella gains a survival advantage within mononuclear phagocytes by suppressing the host IFN gamma response." MOLECULAR IMMUNOLOGY. Vol. 45, no. 12. (July 2008.): 3428-3437.

Rajaram,Murugesan,VS; Butchar,Jonathan,P; Parsa,Kishore,VL; Cremer,Thomas,J; Amer,Amal; Schlesinger,Larry,S; Tridandapani,Susheela. "Akt and SHIP Modulate Francisella Escape from the Phagosome and Induction of the Fas-Mediated Death Pathway." PLOS ONE. Vol. 4, no. 11. (November 2009.): e7919-.

Sweet,Lindsay; Singh,Prachi,P; Azad,Abul,K; Rajaram,Murugesan,VS; Schlesinger,Larry,S; Schorey,Jeffrey,S. "Mannose Receptor-Dependent Delay in Phagosome Maturation by Mycobacterium avium Glycopeptidolipids." INFECTION AND IMMUNITY. Vol. 78, no. 1. (January 2010.): 518-526.

Mohapatra,Nrusingh,P; Soni,Shilpa; Rajaram,Murugesan,VS; Dang,Pham,My-Chan; Reilly,Tom,J; El-Benna,Jamel; Clay,Corey,D; Schlesinger,Larry,S; Gunn,John,S. "Francisella Acid Phosphatases Inactivate the NADPH Oxidase in Human Phagocytes." JOURNAL OF IMMUNOLOGY. Vol. 184, no. 9. (May 2010.): 5141-5150.

Rajaram,Murugesan,VS; Brooks,Michelle,N; Morris,Jessica,D; Torrelles,Jordi,B; Azad,Abul,K; Schlesinger,Larry,S. "Mycobacterium tuberculosis Activates Human Macrophage Peroxisome Proliferator-Activated Receptor gamma Linking Mannose Receptor Recognition to Regulation of Immune Responses." JOURNAL OF IMMUNOLOGY. Vol. 185, no. 2. (July 2010.): 929-942.

Brooks,Michelle,N; Rajaram,Murugesan,VS; Azad,Abul,K; Amer,Amal,O; Valdivia-Arenas,Martin,A; Park,Jong-Hwan; Nunez,Gabriel; Schlesinger,Larry,S. "NOD2 controls the nature of the inflammatory response and subsequent fate of Mycobacterium tuberculosis and M-bovis BCG in human macrophages." CELLULAR MICROBIOLOGY. Vol. 13, no. 3. (March 2011.): 402-418.

Torrelles,Jordi,B; Sieling,Peter,A; Arcos,Jesus; Knaup,Rose; Bartling,Craig; Rajaram,Murugesan,VS; Stenger,Steffen; Modlin,Robert,L; Schlesinger,Larry,S. "Structural Differences in Lipomannans from Pathogenic and Nonpathogenic Mycobacteria That Impact CD1b-restricted T Cell Responses." JOURNAL OF BIOLOGICAL CHEMISTRY. Vol. 286, no. 41. (October 2011.): 35438-35446.

Rajaram,Murugesan,VS; Ni,Bin; Morris,Jessica,D; Brooks,Michelle,N; Carlson,Tracy,K; Bakthavachalu,Baskar; Schoenberg,Daniel,R; Torrelles,Jordi,B; Schlesinger,Larry,S. "Mycobacterium tuberculosis lipomannan blocks TNF biosynthesis by regulating macrophage MAPK-activated protein kinase 2 (MK2) and microRNA miR-125b." PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. Vol. 108, no. 42. (October 2011.): 17408-17413.

Betz,Bret,E; Azad,Abul,K; Morris,Jessica,D; Rajaram,Murugesan,VS; Schlesinger,Larry,S. "beta-Glucans inhibit intracellular growth of Mycobacterium bovis BCG but not virulent Mycobacterium tuberculosis in human macrophages." MICROBIAL PATHOGENESIS. Vol. 51, no. 4. (October 2011.): 233-242.

Cremer,Thomas,J; Fatehchand,Kavin; Shah,Prexy; Gillette,Devyn; Patel,Hemal; Marsh,Rachel,L; Besecker,Beth,Y; Rajaram,Murugesan,VS; Cormet-Boyaka,Estelle; Kanneganti,Thirumala-Devi; Schlesinger,Larry,S; Butchar,Jonathan,P; Tridandapani,Susheela. "MiR-155 induction by microbes/microbial ligands requires NF-?B-dependent de novo protein synthesis.." Frontiers in cellular and infection microbiology. Vol. 2, (January 2012.): 73-?.

Nguyen,Huy,A; Rajaram,Murugesan,VS; Meyer,Douglas,A; Schlesinger,Larry,S. "Pulmonary surfactant protein A and surfactant lipids upregulate IRAK-M, a negative regulator of TLR-mediated inflammation in human macrophages." AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY. Vol. 303, no. 7. (October 2012.): L608-L616.

Canan,Cynthia; Rajaram,Murugesan; Turner,Joanne. "Understanding altered toll-like receptor function in the elderly." JOURNAL OF IMMUNOLOGY. Vol. 190, (May 2013.): P4251-.

Young,Nicholas,A; Wu,Lai-Chu; Burd,Craig; Friedman,Alexandra; Kaffenberger,Benjamin; Rajaram,Murugesan; Schlesinger,Larry,S; James,Hayley; Shupnik,Margaret; Jarjour,Wael,N. "Estrogen Modulates The Expression Of Endosome-Associated Toll-Like Receptor 8 Through Estrogen Receptor-alpha Which May Contribute To Sex-Bias In Systemic Lupus Erythematosus." ARTHRITIS AND RHEUMATISM. Vol. 65, (October 2013.): S270-S271.

Young,Nicholas,A; Friedman,Alexandra,K; Kaffenberger,Benjamin; Rajaram,Murugesan,VS; Birmingham,Daniell,J; Rovin,Brad,H; Hebert,Lee,A; Schlesinger,Larry,S; Wu,Lai-Chu; Jarjour,Wael,N. "Novel estrogen target gene ZAS3 is overexpressed in systemic lupus erythematosus." MOLECULAR IMMUNOLOGY. Vol. 54, no. 1. (May 2013.): 23-31.

Dai,Shipan; Rajaram,Murugesan,VS; Curry,Heather,M; Leander,Rachel; Schlesinger,Larry,S. "Fine Tuning Inflammation at the Front Door: Macrophage Complement Receptor 3-mediates Phagocytosis and Immune Suppression for Francisella tularensis." PLOS PATHOGENS. Vol. 9, no. 1. (January 2013.): e1003114-.

Mohapatra,Nrusingh,P; Soni,Shilpa; Rajaram,Murugesan,VS; Strandberg,Kristi,L; Gunn,John,S. "Type A Francisella tularensis Acid Phosphatases Contribute to Pathogenesis." PLOS ONE. Vol. 8, no. 2. (February 2013.): e56834-.

Hansen,Jesse,M; Golchin,Solmaz,A; Veyrier,Frederic,J; Domenech,Pilar; Boneca,Ivo,G; Azad,Abul,K; Rajaram,Murugesan,VS; Schlesinger,Larry,S; Divangahi,Maziar; Reed,Michael,B; Behr,Marcel,A. "N-Glycolylated Peptidoglycan Contributes to the Immunogenicity but Not Pathogenicity of Mycobacterium tuberculosis." JOURNAL OF INFECTIOUS DISEASES. Vol. 209, no. 7. (April 2014.): 1045-1054.

Moliva,Juan,I; Rajaram,Murugesan,VS; Sidiki,Sabeen; Sasindran,Smitha,J; Guirado,Evelyn; Pan,Xueliang,Jeff; Wang,Shu-hua; Ross,Patrick; Lafuse,William,P; Schlesinger,Larry,S; Turner,Joanne; Torrelles,Jordi,B. "Molecular composition of the alveolar lining fluid in the aging lung." AGE. Vol. 36, no. 3. (June 2014.): 1187-1199.

Azad AK, Rajaram MV, Schlesinger LS.. "Exploitation of the Macrophage Mannose Receptor (CD206) in Infectious Disease Diagnostics and Therapeutics.." Journal of Cytology and Molecular Biology. Vol. 1, no. 1. (January 2014.): 6-.

Hansen JM, Golchin SA, Veyrier FJ, Domenech P, Boneca IG, Azad AK, Rajaram MV, Schlesinger LS, Divangahi M, Reed MB, Behr MA.. "N-glycolylated peptidoglycan contributes to the immunogenicity but not pathogenicity of Mycobacterium tuberculosis.." The Journal of Infectious Disease. Vol. 209, no. 7. (April 2014.): 1045-54.

Young NA, Wu LC, Burd CJ, Friedman AK, Kaffenberger BH, Rajaram MV, Schlesinger LS, James H, Shupnik MA, Jarjour WN.. "Estrogen modulation of endosome-associated toll-like receptor 8: an IFNα-independent mechanism of sex-bias in systemic lupus erythematosus.." Clinical Immunology. Vol. 151, no. 1. (March 2014.): 66-77.

Ni B, Rajaram MV, Lafuse WP, Landes MB, Schlesinger LS.. "Mycobacterium tuberculosis decreases human macrophage IFN-γ responsiveness through miR-132 and miR-26a.." Journal of Immunology. Vol. 193, no. 9. (November 2014.): 4537-47.

Rajaram MV, Ni B, Dodd CE, Schlesinger LS.. "Macrophage immunoregulatory pathways in tuberculosis.." Seminars In Immunology. Vol. 26, no. 6. (August 2014.): 471-85.

Young NA, Wu LC, Burd CJ, Friedman AK, Kaffenberger BH, Rajaram MV, Schlesinger LS, James H, Shupnik MA, Jarjour WN.. "Estrogen modulation of endosome-associated toll-like receptor 8: an IFNα-independent mechanism of sex-bias in systemic lupus erythematosus.." Clinical Immunology. Vol. 151, no. 1. (March 2014.): 66-77.

Landes,Michelle,B; Rajaram,Murugesan,VS; Nguyen,Huy; Schlesinger,Larry,S. "Role for NOD2 in Mycobacterium tuberculosis-induced iNOS expression and NO production in human macrophages.." Journal of leukocyte biology. Vol. 97, no. 6. (June 2015.): 1111-1119.

Chesarino NM, Hach JC, Chen JL, Zaro BW, Rajaram MV, Turner J, Schlesinger LS, Pratt MR, Hang HC, Yount JS.. "Chemoproteomics reveals Toll-like receptor fatty acylation.." BMC Biology. Vol. 12, no. 1. (November 2015.): 91-.

Azad,Abul,K; Rajaram,MVS; Metz,Wendy,L; Cope,Frederick,O; Blue,Michael,S; Vera,David,R; Schlesinger,Larry,S. "gamma-Tilmanocept, a New Radiopharmaceutical Tracer for Cancer Sentinel Lymph Nodes, Binds to the Mannose Receptor (CD206)." JOURNAL OF IMMUNOLOGY. Vol. 195, no. 5. (September 2015.): 2019-2029.

Landes MB, Rajaram MV, Nguyen H, Schlesinger LS.. "Role for NOD2 in Mycobacterium tuberculosis-induced iNOS expression and NO production in human macrophages.." Journal of Lecukocyte Biology. Vol. pii: jlb.3A1114-557R, (March 2015.): pii: jlb.3A1114-557R.

Yao,Zhili; Mates,Jessica,M; Cheplowitz,Alana,M; Hammer,Lindsay,P; Maiseyeu,Andrei; Phillips,Gary,S; Wewers,Mark,D; Rajaram,MVS; Robinson,John,M; Anderson,Clark,L; Ganesan,Latha,P. "Blood-Borne Lipopolysaccharide Is Rapidly Eliminated by Liver Sinusoidal Endothelial Cells via High-Density Lipoprotein." JOURNAL OF IMMUNOLOGY. Vol. 197, no. 6. (September 2016.): 2390-2399.

Dodd CE, Pyle CJ, Glowinski R Rajaram MVS, Schlesinger LS.. "CD36-Mediated Uptake of Surfactant Lipids by Human Macrophages Promotes Intracellular Growth of Mycobacterium tuberculosis.." Journal of Immunology. Vol. 197, no. 12. (December 2016.): 4727-4735.

Makara,Michael,A; Mohler,Peter,J; Rajaram MVS. "Cardiac Electrical and Structural Changes During Bacterial Infection: An Instructive Model to Study Cardiac Dysfunction in Sepsis." JOURNAL OF THE AMERICAN HEART ASSOCIATION. Vol. 5, no. 9. (September 2016.): e003820-.

Xiao,Yun; Tang,Juan; Guo,Hui; Zhao,Yixia; Tang,Rong; Ouyang,Song; Zeng,Qiuming; Rappleye,Chad,A; Rajaram,MVS; Schlesinger,Larry,S; Tao,Lijian; Brown,Gordon,D; Langdon,Wallace,Y; Li,Belinda,T; Zhang,Jian. "Targeting CBLB as a potential therapeutic approach for disseminated candidiasis." NATURE MEDICINE. Vol. 22, no. 8. (August 2016.): 906-.

Cope FO, Abbruzzese B, Sanders J, Metz W, Sturms K, Ralph D, Blue M, Zhang J, Bracci P, Bshara W, Behr S, Maurer T, Williams K, Walker J, Beverly A, Blay B, Damughatla A, Larsen M, Mountain C, Neylon E, Parcel K, Raghuraman K, Ricks K, Rose L, Sivakumar A, Streck N, Wang B, Wasco C, Williams A, Schlesinger LS, Azad A, Rajaram MVS, Jarjour W, Young N, Rosol T, McGrath.. "The inextricable axis of targeted diagnostic imaging and therapy: An immunological natural history approach." Nucl Med Biology. Vol. 43(12):837., no. 12. (December 2016.): 837-.

Ganesan,Latha,P; Mates,Jessica,M; Cheplowitz,Alana,M; Avila,Christina,L; Zimmerer,Jason,M; Yao,Zhili; Maiseyeu,Andrei; Rajaram,MVS; Robinson; Anderson,Clark,L. "Scavenger receptor B1, the HDL receptor, is expressed abundantly in liver sinusoidal endothelial cells." SCIENTIFIC REPORTS. Vol. 6, (February 2016.): 20646-.

Mates JM, Yao Z, Cheplowitz AM, Suer O, Philips GS, Kwiek J, Rajaram MVS, Kim j, Robinson J, Ganesan LP and Anderson CL. "Mouse liver sinusoidal endothelium eliminates HIV-like particles from blood at a rate of 100 million per minute by a second order kinetic process." Front. Immunol. Vol. 8:, no. 35. (January 2017.): doi: 10.3389/fimmu.2017.00035. eCollection 2017.-.

Assani K, Shrestha CL, Robledo-Avila F, Rajaram MVS, Partida-Sanchez S, Schlesinger LS, Kopp BT.. "Human Cystic Fibrosis Macrophages Have Defective Calcium-Dependent Protein Kinase C Activation of the NADPH Oxidase, an Effect Augmented by Burkholderia cenocepacia.." Journal of Immunology. Vol. 198, no. 5. (March 2017.): 1985-1994.

Hoang KV, Borteh HM, Rajaram MVS, Peine KJ, Curry H, Collier MA, Homsy ML, Bachelder EM, Gunn JS, Schlesinger LS, Ainslie KM.. "Acetalated dextran encapsulated AR-12 as a host-directed therapy to control Salmonella infection.." International Journal of Pharmaceutics. -.

 

Reference Works

February 2006 Kishore LV Parsa, Latha P. Ganesan, Murugesan VS Rajaram, .... Susheela Tridandapani."Abstracts and poster presentation" COLUMBUS.
March 2006 Troy Schaffernocker, Jonathan Buthcar, Murugesan VS Rajaram .. Susheela Tridandapani."Abstracts and poster presentation" Columbus.
February 2006 Murugesan VS Rajaram, Kishore VL PArsa, Latha P.Ganesan ...... Susheela Tridandapani."Abstracts and poster presentation" COLUMBUS.
June 2006 Latha P ganesan, Jonathan P. Buthcar, Murugesan VS Rajaram .. Susheela Tridandapani."Abstracts and poster presentation" Hilliard.
November 2006 Murugesan VS Rajaram, Latha P.Ganesan, Kishore LV Parsa.. Susheela Tridandapani."Abstracts and poster presentation" Wood Holes.
November 2006 Joanthan P. Butchar, Murugesan VS Rajaram, Latha P. Ganesan ...... Susheela Tridandapani."Abstracts and poster presentation" Wood Hole.
March 2007 57. Murugesan V.S. Rajaram, Jonathan P. Butchar, Kishore V Parsa, Troy Schaffernocker and Susheela Tridandapani."Abstracts and poster presentation" COLUMBUS.
May 2007 Kishore VL Parsa, Jonathan P. Butchar, Murugesan VS Rajaram.. Susheela Tridandapani."Abstracts and poster presentation" COLUMBUS.
May 2007 56. Troy Schaffernocker, Jonathan P Butchar, Murugesan V.S. Rajaram, Kabbout Mohamed, Ostrowski C Michael, Tridandapani Susheela.."Abstracts and poster presentation" San Fransico.
June 2007 Murugesan VS Rajaram, Jonathan P. Butchar, Kishore VL Parsa . Susheela tridandapani."Abstracts and poster presentation" COLUMBUS.
June 2007 Kishore VL Parsa, Joanathan P. Butchar, Murugesan VS Rajaram ,, Suheela Tridandapani."Abstracts and poster presentation" COLUMBUS.
September 2007 55. Nrusingh P. Mohapatra, Shilpa Soni, Murugesan VS Rajaram, My-Chan Dang, Jamel El benna, Larry S. Schlesinger and John S. Gunn.."Abstracts and poster presentation" COLUMBUS.
April 2008 Murugesan VS Rajaram, Latha P.Ganesan, Kishore VL Parsa,,, Susheela Tridandapani."Abstracts and poster presentation" COLUMBUS.
January 2009 54. Murugesan VS Rajaram, Jordi B. Torrelles and Larry S. Schlesinger.."Abstracts and poster presentation" Keystone, CO.
April 2009 53. Michelle N. Brooks, Murugesan VS Rajaram, Abul K. Azad, Lisa N. Henning, Larry S. Schlesinger."Abstracts and poster presentation" COLUMBUS.
October 2009 52. Michelle N. Brooks, Murugesan VS Rajaram, Abul K. Azad, Martin A. Valdivia-Arenas and Larry S. Schlesinger.."Abstracts and poster presentation" COLUMBUS.
October 2009 51. Murugesan VS Rajaram, Jessica Morris, Michelle N. Brooks, Jordi B. Torrelles, Abul K. Azad and Larry S. Schlesinger.."Abstracts and poster presentation" COLUMBUS.
February 2010 49. Michelle N. Brooks, Murugesan V.S. Rajaram, Abul K. Azad, Martin A. Valdivia-Arenas, and Larry S. Schlesinger.."Abstracts and poster presentation" Banff.
February 2010 48. Murugesan VS Rajaram, Jessica Morris, Michelle N. Brooks, Jordi B. Torrelles, Abul K. Azad and Larry S. Schlesinger.."Abstracts and poster presentation" Banff.
July 2010 50. Larry S. Schlesinger, Jessica Morris, Michelle N. Brooks, Jordi B. Torrelles, Abul K. Azad and Murugesan V.S. Rajaram."Abstracts and poster presentation" Boston.
September 2010 42. Larry S. Schlesinger Bin Ni, Jessica Morris, Michelle N. Brooks, Tracy K. Carlson, Jordi B. Torrelles and Murugesan V.S. Rajaram."Abstracts and poster presentation" Paris.
October 2010 Murugesan V.S. Rajaram, Jessica D. Morris, Michelle N. Brooks, Tracy K. Carlson, Jordi B. Torrelles, and Larry S. Schlesinger."Abstracts and poster presentation" COLUMBUS.
January 2011 Murugesan V.S.Rajaram, Jessica Morris, Michelle N. Brooks, Jordi B. Torrelles and Larry S. Schlesinger."Abstracts and poster presentation" Vancouver.
January 2011 Michelle N. Brooks, Murugesan V.S Rajaram, Abul K. Azad, Amal O. Amer, Martin A. Valdivia-Arenas, Jopng-Hwang Park, Gabriel Nunez and Larry S. Schlesinger."Abstracts and poster presentation" Vancouver.
April 2011 Michelle N. Brooks, Murugesan V.S. Rajaram, Bin Ni, Huy A. Nguyen, and Larry S. Schlesinger."Abstracts and poster presentation" COLUMBUS.
April 2011 Bin Ni, Murugesan V.S. Rajaram, Michelle N. Brooks, Huy A. Nguyen, Stefano Volinia, and Larry S. Schlesinger."Abstracts and poster presentation" COLUMBUS.
October 2012 Murugesan V.S Rajaram, Bin Ni, Tracy Carlson and Larry S. Schlesinger."Abstracts and poster presentation" COLUMBUS.
October 2012 Bin Ni, Murugesan V.S. Rajaram, Michelle B. Landes, Huy A. Nguyen, and Larry S. Schlesinger."Abstracts and poster presentation" COLUMBUS.
March 2013 Murugesan V.S. Rajaram, Bin Ni, Tracy Carlson and Larry S. Schlesinger."Abstracts and poster presentation" whistler.
March 2013 Bin Ni, Murugesan V.S. Rajaram, Michelle B. Landes, Huy A. Nguyen, and Larry S. Schlesinger."Abstracts and poster presentation" COLUMBUS.
March 2013 Bin Ni, Murugesan V.S. Rajaram, Michelle B. Landes, Huy A. Nguyen, and Larry S. Schlesinger."Abstracts and poster presentation" Whistler.
April 2013 Murugesan V.S. Rajaram, Bin Ni, Tracy Carlson and Larry S. Schlesinger."Abstracts and poster presentation" COLUMBUS.
April 2013 Ky V. Hoang, Eric Bachelder, Hassan Borteh, Murugesan V. S. Rajaram, Heather Curry, Kristy Ainslie, John S. Gunn, and Larry S. Schlesinger."Abstracts and poster presentation" COLUMBUS.
June 2013 Abul K. Azad, Murugesan V.S. Rajaram, Wendy L. Metz, Frederick O. Cope, Michael S. Blue, David R Vera, and Larry S. Schlesinger."Abstracts and poster presentation" Water Valey Springs.
July 2013 Bin Ni, Murugesan V. S. Rajaram, M. B. Landes, L. S. Schlesinger."Abstracts and poster presentation" Key Stone.
August 2013 Ky V. Hoang, Eric Bachelder, Hassan Borteh, Murugesan V. S. Rajaram, Heather Curry, Kristy Ainslie, John S. Gunn, and Larry S. Schlesinger."Abstracts and poster presentation" COLUMBUS.
August 2013 Bin Ni, M. V. S. Rajaram, C. Torres, M. B. Landes, L. S. Schlesinger."Abstracts and poster presentation" COLUMBUS.
April 2013 Danielle House, Murugesan VS Rajaram and Larry S. Schlesinger."Abstracts and poster presentation" COLUMBUS.
April 2013 Chelsea TORRES, Bin NI, Murugesan V.S. RAJARAM and Larry S. SCHLESINGER."Abstracts and poster presentation" COLUMBUS.
April 2013 Chelsea TORRES, Bin NI, Murugesan V.S. RAJARAM and Larry S. SCHLESINGER."Abstracts and poster presentation" COLUMBUS.
April 2013 Bin Ni, Murugesan V.S. Rajaram, Michelle B. Landes, Huy A. Nguyen, and Larry S. Schlesinger."Abstracts and poster presentation" COLUMBUS.
April 2013 Abul K. Azad, Murugesan V.S. Rajaram, Wendy L. Metz, Frederick O. Cope, Michael S. Blue, David R Vera, and Larry S. Schlesinger."Abstracts and poster presentation" COLUMBUS.
May 2013 LS Schlesinger, AK Azad, Murugesan VS Rajaram, A Agrawal, BC Abbruzzese, MS Blue, J Shuping, B Potter, WL Metz, and FO Cope (2013."Abstracts and poster presentation" San Fransico.
May 2013 LS Schlesinger, AK Azad, Murugesan VS Rajaram, A Agrawal, BC Abbruzzese, MS Blue, J Shuping, B Potter, WL Metz, and FO Cope."Abstracts and poster presentation" San Fransico.
May 2013 Cynthia Canan, Murugesan V.S.Rajaram and Joanne Turner."Abstracts and poster presentation" Honolulu.
June 2013 Ky V. Hoang, Eric Bachelder, Hassan Borteh, Murugesan V. S. Rajaram, Heather Curry, Kristy Ainslie, John S. Gunn, and Larry S. Schlesinger."Abstracts and poster presentation" COLUMBUS.
June 2013 Danielle House, Murugesan VS Rajaram and Larry S. Schlesinger."Abstracts and poster presentation" COLUMBUS.
September 2014 Claire E Dodd, Murugesan VS Rajaram and Larry S Schlesinger."Abstracts and poster presentation" Chicago.
October 2014 Arnett E, Murugesan VS Rajaram, Schlesinger LS."Abstracts and poster presentation" COLUMBUS.
November 2014 Arnett E, Murugesan VS Rajaram, Schlesinger LS."Abstracts and poster presentation" COLUMBUS.
May 2014 Murugesan V.S. Rajaram, Bin Ni, Tracy Carlson and Larry S. Schlesinger."Abstracts and poster presentation" Pittsburg.
January 2015 Murugesan V.S. Rajaram, William P.Lafuse, Rachel L. Gearinger, Aleksandra I. Adamovich, Russell Ault, and Larry S. Schlesinger."Abstracts and poster presentation" Santa Fe.
May 2015 Murugesan V.S. Rajaram, Bin Ni, Eusondia Arnett, Abul K Azad and Larry S. Schlesinger."Abstracts and poster presentation" New Orleans.
May 2015 Claire E Dodd, Murugesan VS Rajaram and Larry S Schlesinger."Abstracts and poster presentation" COLUMBUS.
May 2015 Arnett E, Murugesan VS Rajaram, Schlesinger LS."Abstracts and poster presentation" Waterville Valley.
May 2015 Bin Ni, C. Torres, M. V. S. Rajaram and L. S. Schlesinger."Abstracts and poster presentation" New Orleans.
May 2015 Arnett E, Murugesan VS Rajaram, Joshua Keaton, and Larry S Schlesinger."Abstracts and poster presentation" COLUMBUS.
August 2015 Claire E. Dodd, Murugesan V.S. Rajaram and Larry S. Schlesinger."Abstracts and poster presentation" Indianapolis.
September 2015 K. V. Hoang, H. Curry, Murugesan V. S. Rajaram, M. A. Collier, H. Borteh, E. Bachelder, K. Ainslie, L. S. Schlesinger and J. S. Gunn."Abstracts and poster presentation" San Diego.
June 2016 See attached Appendix-I."Abstracts and poster presentation" Keystone, CO.
February 2016 Murugesan V.S. Rajaram, Abul K. Azad, Eusondia Arnett, Evelyn Guirado, Bin Ni, Li-Zhen He, Tibor Keler, Lawrence J. Thomas, William P Lafuse and Larry S. Schlesinger."Abstracts and poster presentation" Keystone, CO.
February 2016 Eusondia Arnett, Joshua Keaton, Murugesan VS Rajaram, and Larry S Schlesinger."Abstracts and poster presentation" Keystone, CO.
February 2016 Claire E. Dodd, Murugesan V.S. Rajaram and Larry S. Schlesinger."Abstracts and poster presentation" Keystone, CO.
September 2016 Ky Hong, Murugesan V.S. Rajaram, Heather Curry, Mikhail A. Garvilin, Mark D. Wewers, and Larry S. Schlesinger."Abstracts and poster presentation" Urbana Chanpaign.
May 2017 Murugesan VS Rajaram, Colwyn Headley, Nathaniel Murphy, Peter J. Mohler and Joanne Turner."Abstracts and poster presentation" Bethesda.
May 2017 Murugesan VS Rajaram, Colwyn Headley, Nathaniel Murphy, Peter J. Mohler and Joanne Turner."Abstracts and poster presentation" Washington DC.
May 2017 William P Lafuse, Murugesan VS Rajaram, Heather M Curry, Connor Nealer, Cynthia H Canan, Juan I Moliva, Jordi B Torrelles, Joanne Turner, and Larry S Schlesinger."Abstracts and poster presentation" Washington DC.
May 2017 William P Lafuse, Murugesan VS Rajaram, Heather M Curry, Connor Nealer, Cynthia H Canan, Juan I Moliva, Jordi B Torrelles, Joanne Turner, and Larry S Schlesinger."Abstracts and poster presentation" Bethesda.

Presentations

"Mycobacterium tuberculosis activates human macrophage PPARγ linking mannose receptor recognition to regulation of immune responses." Presented at CMIB research re-treat 2010, . (March 2010)

"M. tuberculosis lipomannan blocks TNF biosynthesis by regulating macrophage MAPK-Activated Protein Kinase 2 (MK2) and miR125b." Presented at CMIB Work In Progress, Columbus, US|USA. (January 2011)

"Unraveling the Mystery of Macrophage Mannose Receptor Signaling: a Major Pattern Recognition Receptor in Immunity." Presented at CMIB Work In Progress, . (January 2012)

"Mannose receptor (CD206)-mediated signaling events in human macrophages in the context of tuberculosis." Presented at CMIB WIP, . (March 2013)

"Mannose receptor mediated signaling in human macrophages in the context of tuberculosis." Presented at American Association of Immunologist Annual Meeting 2014, Piitsburg, PA, US|USA. (May 2014)

"AAI annual meeting Block Symposium." Presented at AAI Annual Meeting 2015, New Orleans, LA, US|USA. (May 2015)

"FcR-chain, Grb2 and SHP-1 are invovled in mannose receptor (CD206)-mediated signaling in relation to tuberculosis." Presented at AAI Annual Meeting, New Orleans, LA, US|USA. (May 2015)

"Oral: Cardiac electrical and structural changes during bacterial infection: an instructive model to study cardiac dysfunction in sepsis." Presented at AAI Annual Meeting, Seattle, WA, US|USA. (May 2016)

"Mechanisms of immune invasion by Mycobacterium tuberculosis." Presented at Everett D. Reese Immunology and Rheumatology research Seminar Series, COLUMBUS, OH, US|USA. (November 2017)

 

Technical Reports

Murugesan V. S. Rajaram, Michelle N. Brooks, Jessica D. Morris, Jordi B. Torrelles, Abul K. Azad, and Larry S. Schlesinger, "Tuberculosis Tyranny". Vol. 185. no. 2. Edited by Christiana N. Fogg, Ph.D.. American Association of Immunology. (3, 2010) [Peer-Review] (Published)

Frederick Cope, Wendy Metz, Mark Pykett, Michael Blue, Beth Potter, David Colborn, Bonnie Abbruzzese, Joanna Shuping, Cornelia Reininger, Abul Azad Murugesen Rajaram, Larry Schlesinger, Wael Jarjour, Thomas Rosol, Ramiro Toribio, Michael McGrath, Leanne Huysentruyt, Rongzhen Zhang & Paige Bracci, "Innovations in receptor-targeted precision imaging at Navidea: diagnosis up close and personal". Vol. 502. Nature. (7473, 2013) [Editor-Review] (Published)

 

Unpublished Works

Zhili Yao, Charu Tiwari, Mustafa Al-Rahem , John M. Robinson , Mark D. Wewers, Clark L. Anderson, Murugesan VS. Rajaram and Latha P. Ganesan. TLR4 mediated immune functions in Liver endothelium.

Colwyn Headley, Nathaniel Murphy, Peter J. Mohler, Joanne Turner and Murugesan VS Rajaram. Influence of age on mycobacterial myocarditis and heart failure.

Ky Hong, Murugesan V.S. Rajaram, Heather Curry, Mikhail A. Garvilin, Mark D. Wewers, and Larry S. Schlesinger. Complement receptor 3-mediated suppression of the inflammasome by RasGAP during Francisella tularensis infection of human mononuclear phagocytes. March 2017.

Ozan Suer, Zhili Yao, Alana M. Cheplowitz, Charu Tiwari, Sueng Chu, David E. Szymkowski, Murugesan VS. Rajaram, John M. Robinson, Jonghan Kim, Dennis R. Burton, Clark L. Anderson, Lars Hangartner and Latha P. Ganesan. Anti-HIV antibodies accelerate clearance of blood-borne HIV via an FcγRIIb-mediated effector function of liver sinusoidal endothelial cells.. September 2017.

William P Lafuse, Murugesan VS Rajaram, Heather M Curry, Connor Nealer, Cynthia H Canan, Juan I Moliva, Jordi B Torrelles, Joanne Turner, and Larry S Schlesinger. Influence of aging on the phenotype and function of alveolar macrophages.