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Jonathan Honegger, PhD


700 Childrens Dr
Columbus, OH 43205

Phone: (614) 722-4450

Email: honegger.6@osu.edu

 

Current OSU Appointment

Assistant Professor-Clinical, Pediatrics

 

Master/Graduate Advising

I have worked with Christopher Walker as a co-advisor for Samantha Ohmer since 2014.  Samantha is an MD/PhD candidate in the Medical Scientist Training Program.  Dr. Walker is listed as Samantha's dissertation advisor within the Biomedical Sciences Graduate Program due to my "M" faculty status, but I have continued to operate as Samantha's co-advisor, being particularly involved with her supervision on a day-to-day basis.  

Noteworthy Graduate Narrative

Samantha Ohmer, MSTP student class of 2020


 























Publications




Honegger JR, Tedesco D, Kohout JA, Prasad MR, Price AA, Lindquist T, Ohmer S, Moore-Clingenpeel M, Grakoui A, Walker CM. Influence of IFNL3 and HLA-DPB1 genotype on postpartum control of hepatitis C virus replication and T-cell recovery. Proceedings of the National Academy of Sciences. 2016;113(38):10684-9.




Wen J, Ohmer S, Honegger J. Hepatitis C Virus Infection in Pregnancy and Childhood. In: Miyamura T, Lemon SM, Walker CM, Wakita T, editors. Hepatitis C Virus II: Infection and Disease. Tokyo: Springer Japan; 2016. p. 187-222.




Ohmer S, Honegger J. New Prospects for the Treatment and Prevention of Hepatitis C in Children. Current opinion in pediatrics. 2016;28(1):93-100.




In preparation:




-          Ohmer et al.  Recovery of HCV-specific CD4+ helper T cell immunity in the postpartum period




-          Ohmer et al.  Postpartum virus-specific cellular immunity in HIV-HCV co-infection




Abstract Presentations




Ohmer S. Walker C, Honegger JR. “Restoration of HCV-specific CD4 T cell function in the postpartum period.” Abstract. OSU Research Day 2017. Columbus, OH.




Ohmer S. Walker C, Honegger JR. “Restoration of HCV-specific CD4 T cell function in the postpartum period.” Abstract. Keystone Symposium on Viral Immunity, February 2017. Santa Fe, NM.




Ohmer S, Honegger JR. “CD4 T cell signatures associated with postpartum control of the hepatitis C virus.” Oral presentation and abstract. Nationwide Children’s Hospital ID Consortium Research Day 2017.  Columbus, OH.




Ohmer S, Honegger JR. “HCV-specific CD4 T cell function correlates with viral control in the postpartum period.” Abstract. Nationwide Children’s Hospital Research Institute Annual Retreat 2016. Columbus, OH.




Ohmer S, Honegger JR. “Postpartum changes in CD4 T cell immunity to chronic hepatitis C virus infection.” Oral presentation and abstract. OSU Biomedical Sciences Graduate Program Retreat 2016.  Columbus, OH.




Ohmer S, Honegger JR. “Postpartum recovery of HCV-specific CD4 T cell function.” Abstract. OSU Research Day 2016. Columbus, OH.




Ohmer S, Honegger JR. “Restoration of HCV-specific CD4 T cell function in the postpartum period.” Abstract. Nationwide Children’s Hospital Research Institute Annual Retreat 2015. Columbus, OH.




Ohmer S, Honegger JR. “Restoration of HCV-specific CD4 T cell function in the postpartum period.” Abstract. OSU MSTP Summer Retreat 2015. Columbus, OH.




Ohmer S, Honegger JR. “Postpartum HCV-specific T cell recovery in women chronically infected with hepatitis C virus.” Abstract. OSU Research Day 2015. Columbus, OH.




Ohmer S, Honegger JR. “HCV-specific post-partum T cell function in women chronically infected with hepatitis C virus.” Abstract. ID Week 2015. San Diego, CA.




Awards




Graduate Student Travel Award – 24th International Meeting on Hepatitis C and Related Viruses in Cape Cod, MA  (Sept 2017)




Diversity Award  - MD/PhD Student Conference in Keystone, CO  (July 2016)




OSU MSTP Leadership Award (Autumn 2014)




Fellowship Awards




OSU Graduate Student Pelotonia Fellowship (2016-2018)




Nationwide Children’s Hospital Trainee Fellowship (2015-2016)




OSU University Fellowship (2014-2015)



 


 


 


Samuel Kennedy, medical student class of 2020


 















Publications




In preparation (Kennedy as middle author):  Linking birth certificate and disease-reporting databases to better quantify the hepatitis C epidemic in pregnant women in Ohio. 




Awards




OSU College of Medicine Medical Student Research Scholarship


Postdoctoral / Researcher Advising

Pediatric Fellows - Scholarship Oversight Committe Membership










































2017-



Mary Frances Wedekind, Pediatric Hematology-Oncology Fellow, Nationwide Childrens Hospital



2017



Kathleen Overholt, Pediatric Hematology-Oncology Fellow, Nationwide Children's Hospital



2016-2017



Musaed Alharbi, Pediatric Infectious Diseases Fellow, Nationwide Children's Hospital



2014-2016



Christopher Ouellette, Pediatric Infectious Diseases Fellow, Nationwide Children's Hospital



2012-2015



Ruchika Sharma, Pediatric Hematology-Oncology Fellow, Nationwide Children's Hospital



2012-2015



Joshua Watson, Pediatric Infectious Diseases Fellow, Nationwide Children's Hospital



2012-2014



Christine Zamastil, Pediatric Infectious Diseases Fellow, Nationwide Children’s Hospital



2012-2014



Ryan Cox, Pediatric Gastroenterology Fellow, Nationwide Children’s Hospital



2010-2011



Adebomi Omikunle, Pediatric Infectious Diseases Fellow, Nationwide Children’s Hospital


Continuing Education, Extension, and Other Courses Taught

As part of my interest in improving the care of HCV-exposed and infected children, I have lectured about HCV to numerous physician and ancillary providers in Ohio.  I have also given lectures on other pediatric infectious disease topics. 

Student Life Activity Narrative

My greatest degree of interaction with medical students occurs when attending on the inpatient service and when teaching in the HIV clinic.  I take these opportunities to not only teach medicine, but also to learn students' interests and career ambitions. I have more extended discussions with some students about career decisions,  particularly those interested in pediatrics or infectious diseases. 

Biographical

As a clinician-researcher at Nationwide Children’s Hospital and The Ohio State University, the focus of my work has been the increasingly prevalent problem of hepatitis C virus (HCV) infection in pregnancy and childhood.  My research centers particularly on the influence of pregnancy on T-cell immunity to HCV.  This interest was born during my pediatric infectious diseases fellowship training.  In the course of a pilot study on HCV vertical transmission, I noted that some infected mothers experienced profound declines in HCV virus levels in the bloods several months after childbirth.  The sharp drop in viremia was striking because chronic HCV infection is typically characterized by stable viremia and exhausted cellular immunity.  I hypothesized that the postpartum period facilitates natural functional restoration of T-cell responses against HCV.  To test this hypothesis I worked with my mentor Christopher Walker to establish an NIH-funded prospective cohort of HCV-infected pregnant women who are followed through the postpartum period.  Through this cohort we have learned that approximately one-third of women experience a significant postpartum viral load decline (10-10,000 fold), that this viral load decline is indeed associated with improved antiviral cytokine secretion by HCV-specific T-cells, and that postpartum viral control can be predicted by two genetic polymorphisms—one at an interferon-λ locus (IFNL3) and one affecting expression of class II HLA-DP molecules.  These findings highlighted the utility of examining postpartum HCV control as a model of immune restoration, revealing novel factors not previously linked to HCV control (HLA-DP expression), and factors relevant to immune control of viruses beyond HCV.   For instance, we subsequently found that the IFNL3 polymorphism also predicts postpartum expression of innate antiviral genes in healthy women who are not infected with HCV.  Another key study examined HCV genomic evolution in pregnant women.  This study provided corroborating evidence for enhanced CD8+ cytotoxic T-cell activity after delivery.  It also indicated that CD8+ T-cell activity was relaxed during pregnancy.  This finding had surprising clinical relevance, as relaxation of CD8+ T-cell immunity during pregnancy allowed emergence of wild-type HCV variants with enhanced replicative capacity that could be transmitted to infants in cases of vertical transmission.  To our knowledge, the effects of pregnancy on viral evolution had not been previously evaluated for any virus.  The significance of this study was recognized in a Faculty of 1000 commentary. 


 


Beyond these immunological studies, as a clinician I have also taken interest in the practical problem of pediatric HCV diagnosis and treatment.  By some estimates, only 5-15% of vertically infected infants have been diagnosed.  Reasons for this are not well studied but likely related to social factors, a prolonged interval from birth to testing in standard testing algorithms, and limited awareness of HCV among pediatric providers.  To address these problems I have developed local testing guidelines, lectured to outlying clinician and nurse groups, overseen launch of a screening clinic for HCV-exposed infants, and authored review articles on HCV in childhood.  Our local efforts to improve screening appear to have contributed in part to a more than 10-fold increase in the annual number of young children diagnosed with HCV at NCH since 2008.  Finally, I have served as a site primary investigator for clinical trials testing several novel combination direct-acting antiviral agents to treat children with chronic HCV infection.   


 


My work in translational and clinical aspects of maternal and pediatric HCV infection has earned national recognition.   After joining the faculty of Nationwide Children’s Hospital and Ohio State University in 2008 my laboratory studies were initially supported by K12 funding.  With my mentor Chris Walker, I co-wrote an R01 grant application for studies of immunity to HCV in pregnancy and have been supported by extramural NIH funding since 2011.   I have been able to publish findings from these studies as first and corresponding author in high-impact journals including Nature Medicine and PNAS, and I have been invited to present my research at Emory University, Rockefeller University, Case Western Reserve University, and an NIH Cooperative Research Centers Workshop.  Further I have given invited symposium presentations at the Pediatric Academic Societies meeting and an international pediatric hepatology meeting in Egypt, the nation with the highest prevalence of HCV in the world.    I have been asked to author numerous review articles and several chapters in first-edition textbooks on HCV in pregnancy and childhood, and I have provided peer review for journals including Clinical Infectious Diseases, Journal of Hepatology, and Plos Pathogens.  In 2015-2016 I was invited to participate in a writing committee to update the NIH AIDSinfo guidelines on HCV co-infection in HIV-infected children.  Finally, my reputation in pediatric HCV led to an invitation to serve as a pediatric representative on the FDA Antiviral Advisory Drug Committee in 2013 at a time when the FDA faced a wave of applications for novel direct acting antiviral drugs for HCV.  In 2015 the FDA’s antiviral and antibacterial advisory committees were consolidated into the Antimicrobial Drugs Advisory Committee, and I was asked to continue to serve as a member of this committee.

Quality Indicators

Beyond the citation analysis and journal impact factor listed below, several of my publications have been ranked by alternative metrics:





























ManuscriptAltmetrics
Price et al. PNAS 201651
Honegger et al. PNAS 201648
Ohmer et al.  Current Opinion in Pediatrics 20164
Honegger et al. Semin Liver Dis. 20147
Honegger et al.  Nature medicine 201385

 


 


Article Citations (Web-of-science)
























































































































Year



First-authorship citations



Last-authorship citations



Co-authorship citations



Sole-authorship citations



Totals



 



Self-Cited



Not Self-Cited



Self-Cited



Not Self-Cited



Self-Cited



Not Self-Cited



Self-Cited



Not Self-Cited



Self-Cited



Not Self-Cited



2012



0



0



0



0



0



2



 



 



0



2



2013



0



0



0



2



0



2



 



 



0



4



2014



1



10



0



2



0



2



 



 



1



14



2015



0



17



0



5



0



3



 



 



0



25



2016



3



10



1



16



0



4



 



 



4



30



2017



0



9



0



5



0



5



 



 



0



19



Totals



4



46



1



30



0



18



0



0



5



94


Academic Advising

2012 - present Ryan Cox, Nationwide Children’s Hospital.
2013 - present , Nationwide Children’s Hospital.
2014 Samantha Ohmer, The Ohio State University. Graduated 0.
 

Licenses

2004 - 2014 Certified: American Board of Pediatrics
2004 - 2014 Certified: American Board of Internal Medicine
2009 - 2016 Certified: American Board of Pediatrics
 

Chapters in Books

Honegger JR, Brady MT. "Viral Respiratory Infections." In Rudolph's Pediatrics. 22nd ed. Edited by Colin Rudolph, Abraham Rudolph, George Lister, Lewis First, Anne Gershon. -. New York, NY, US|USA: McGraw-Hill Publishers, January 2011.

 

Conferences

Honegger J, Potter C, Cawthon D, Walker C,. "Intrahepatc cellular immunity in vertically acquired hepatitis C virus infection." St. Jude’s/Pediatric Infectious Diseases Society Meeting. (January 0). .

Bowen DG, Cawthon AG, Honegger JR, Rutkiewicz J, Murthy KK, Walker CM. "High-level HCV replication during acute infection occurring in the absence of reversion of previously acquired cytotoxic T lymphocyte escape mutations." In Hepatology. (October 2006). 296A-296A.

Honegger JR, Prasad MR, Colombo D, Bowen DG, Walker CM. "HCV-specific T-cell responses during acute Hepatitis C Virus infection in pregnancy." In Retrovirology. (April 2008). O8-.

Honegger JR, Prasad MR, Kohout JA, Walker CM. "Influence of Pregnancy on Hepatitis C Virus Evolution." 17th International Meeting on Hepatitis C and Related Viruses Program and Abstract Book. (September 2010). P-205.

Honegger JR, Kohout JA, Kim S, et al.. "Reversion of cytotoxic T-cell escape mutation during pregnancy permits vertical transmission of most fit hepatitis C variant." 18th International Symposium on Hepatitis C Virus and Related Viruses Abstract Book. (September 2011). P2.20-.

Omikunle A, Walker CM, Honegger JR. "Hepatitis C virus specific T-cell responses in vertically exposed infants." Pediatric Academic Societies Abstract2View. (May 2011). 2941.449-.

Prasad MR, Honegger JR, Markham KB; Walker CM. "Clinical risk factors associated with mother-to-child transmission (MTCT) of hepatitis C virus (HCV)." In American Journal of Obstetrics and Gynecology. (January 2012). S270-S270.

 

Degrees

1995 B.S., Purdue University

2000 M.D., Indiana University

 

Editorial Activities

2012 - present PLOS Pathogens
2013 - present PLOS One
2013 - present Pediatric Infectious Diseases Journal
2014 - present American Journal of Perinatology
2015 - present Frontiers in Pediatrics
 

Honors

2009 - present IDSA Program Committee Career Award. Infectious Diseases Society of America.
 

Journal Articles

Dotson JL, Crandall W, Mousa H, Honegger JR, Denson L, Samson C, Cunningham D, Balint J, Deinhart M, Jaggi P, Carvalho R. "Presentation and Outcome of Histoplasmosis in Pediatric Inflammatory Bowel Disease Patients Treated with Antitumor Necrosis Factor alpha Therapy: A Case Series." Inflammatory Bowel Diseases. Vol. 17, no. 1. (January 2011.): 56-61.

Dotson,Jennifer,L; Crandall,Wallace; Mousa,Hayat; Honegger,Jonathan,R; Denson,Lee; Samson,Charles; Cunningham,Dennis; Balint,Jane; Dienhart,Molly; Jaggi,Preeti; Carvalho,Ryan. "Presentation and Outcome of Histoplasmosis in Pediatric Inflammatory Bowel Disease Patients Treated with Antitumor Necrosis Factor alpha Therapy: A Case Series." INFLAMMATORY BOWEL DISEASES. Vol. 17, no. 1. (January 2011.): 56-61.

Prasad,Mona; Honegger,Jonathan; Markham,Kara,B; Walker,Christopher. "Clinical risk factors associated with mother-to-child transmission (MTCT) of hepatitis C virus (HCV)." AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY. Vol. 206, no. 1. (January 2012.): S270-S270.

Prasad,Mona; Honegger,Jonathan; Markham,Kara,B; Walker,Christopher. "Clinical risk factors associated with mother-to-child transmission (MTCT) of hepatitis C virus (HCV)." AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY. Vol. 206, no. 1. (January 2012.): S270-S270.

Prasad MR, Honegger JR. "Hepatitis C Virus in Pregnancy." American Journal of Perinatology. Vol. 30, no. 2. (February 2013.): 149-159.

Honegger JR, Kim S, Price AA, Kohout JA, McKnight KL, Prasad MR, Lemon SM, Grakoui A, Walker CM. "Loss of immune escape mutations during persistent HCV infection in pregnancy enhances replication of vertically transmitted viruses." Nature Medicine. Vol. 19, no. 11. (November 2013.): 1529-1533.

Honegger JR, Zhou Y, Walker CM. "Will there be a vaccine to prevent HCV infection?." Seminars in Liver Diseases. Vol. 34, no. 1. (February 2014.): 79-88.

Price AA, Grakoui A, Honegger JR. "Hepatitis C virus adaptions to altered CD8+ T-cell immunity during pregnancy." Future Virology. Vol. 9, no. 4. (April 2014.): 333-336.

Barson WJ, Honegger JR, Texter K. "Acute myopericarditis associated with cat scratch disease in an adolescent." Pediatric Infectious Disease Journal. Vol. 33, no. 9. (September 2014.): 982-984.

Honegger JR, Zhou Y, Walker CM. "Will there be a vaccine to prevent HCV infection?." Seminars in Liver Disease. -.

 

Presentations

"Intrahepatic Cellular Immunity in Vertically Acquired Hepatitis C Virus Infection." Presented at St. Jude's/PIDS Pediatric Infectious Diseases Conference, Memphis, TN, US|USA. (February 2007)

"T-cell Immunity to Hepatitis C Virus Infection During Pregnancy." Presented at Research Institute Annual Retreat, Columbus, OH, US|USA. (March 2008)

"Maternal and Infant T-cell Immunity to the Hepatitis C Virus." Presented at Clinical Research Seminar, Columbus, OH, US|USA. (June 2008)

"Maternal Immunity to the Hepatitis C Virus." Presented at Immunology Journal Club/Work in Progress, Columbus, OH, US|USA. (September 2008)

"Postpartum Surge in T-cell Immunity to the Hepatitis C Virus." Presented at NIH (NICHD) Child Health Research Centers Annual Retreat, Seattle. (September 2009)

"Postpartum Surge in T-cell Immunity to the Hepatitis C Virus." Presented at Infectious Diseases Society of America Annual Meeting, Philadelphia, PA, US|USA. (October 2009)

"Preventing Mother to Child Transmission of the Hepatitis C Virus." Presented at BOSS Seminar, Columbus. (May 2009)

"Hepatitis C in Pregnancy and Vertical Transmission." Presented at Nationwide Children's Hospital Gastroenterology Morning Conference, Columbus, OH, US|USA. (July 2011)

"Hepatitis C Update." Presented at Association of Ohio Health Commissioners Fall Conference, Dublin. (September 2012)

"T-cell immunity to Hepatitis C in mothers and infants - learning from the virus." Presented at ID Consortium Work in Progress, Nationwide Children's Hospital, Columbus, OH, US|USA. (November 2012)

"Broadened Virus-Specific T-cell Responses are Associated with Postpartum Declines in Hepatitis C Viremia." Presented at Infectious Diseases Society of America Annual Meeting, San Diego, CA, US|USA. (October 2012)

"Hepatitis C Update." Presented at Nationwide Children's Hospital Gastroenterology Morning Conference, Columbus, OH, US|USA. (January 2013)

"Hepatitis C in Pregnancy: a Unique Setting to Understand Restoration of Immunity." Presented at Hepatitis C Cooperative Research Centers Immunology Workshop, Bethesda, MD, US|USA. (July 2013)

"Hepatitis C in Pregnancy--How Altered Maternal Immunity can Influence Replicative Capacity of Vertically Transmitted Viruses." Presented at Emory Vaccine Center Special Seminar, Atlanta, GA, US|USA. (February 2013)

"Hepatitis C in Pregnancy—How Altered Maternal Immunity can Influence Replicative Capacity of Vertically Transmitted Viruses." Presented at Hepatitis C Seminar Series, New York, NY, US|USA. (November 2013)

"Cellular immunity to the hepatitis C virus during and after pregnancy." Presented at Center for Aids Research Seminar Series, Cleveland, OH, US|USA. (February 2014)

"The Immunology Behind Perinatal Hepatitis C Transmission." Presented at Pediatric Academic Societies Annual Meeting, Vancouver, BC, CA|CAN. (May 2014)

"Immunity Before and After Perinatal Hepatitis C Infection." Presented at ID Consortium Work in Progress, Nationwide Children's Hospital, Columbus, OH, US|USA. (August 2014)

 

Professional Activities

2015 - present Antimicrobial Drugs Advisory Committee. Food and Drug Administration. Silver Springs, MD.
2009 Pediatric infectious diseases teaching and consultation services. Rumah Sakit Umum Bethesda.
2011 Pediatric infectious diseases teaching and consultation services. Rumah Sakit Umum Bethesda.
2013 - 2015 Antiviral Drugs Advisory Committe. Food and Drug Administration. Silver Spring, MD.