Ohio State Navbar

People

Abraham Badu-Tawiah, PhD


100 W 18th Ave
Columbus, OH 43210

Phone: (614) 292-4276

Email: badu-tawiah.1@osu.edu

 

Current OSU Appointment

Assistant Professor, Chemistry and Biochemistry

 

Biographical

Abraham Badu-Tawiah obtained his Ph.D. (2012) in Chemistry with R. Graham Cooks at Purdue University. During that time he worked on the mechanism of desorption electrospray ionization, which led to the development of novel instrumentation for ambient ion soft landing, and ionic reactions with neutral species adsorbed on ambient surfaces. This training in ion manipulation at atmospheric pressure laid the ground work for the creation of analytical devices that permit ion chemistry to be performed more effectively using charged micro-droplets as reaction vessels. During his time at Purdue, Dr. Badu-Tawiah was awarded Andrews (2007 – 2009), Bilsland Dissertation (2011), and Lilly Innovative (2012) Fellowships. From 2012 to 2014, he was a postdoctoral fellow at Harvard University under the direction of George M. Whitesides, where his research focused on the development of methods for performing molecular recognition (immunoassay) on ambient paper surfaces for use in resource-limited disease eradication programs. The main objective of this project was to develop a device that decouples analyte capture from signal amplification, so that the latter step can be performed time independently. This objected was achieved by coupling polymerization-based amplification methods to a paper-based device. The immunoassay and the radical-mediated polymerization were all performed under ambient conditions, with no oxygen purging. In 2014, he joined The Ohio State University, Department of Chemistry and Biochemistry. His research group is focused on the development of new mass spectrometry (MS) based techniques for on-demand disease detection, real-time reaction screening, and quantitative chemical analysis. Here, stable, cleavable ionic probes have been rationally designed and synthesized that enable immunoassay tests performed on paper substrates to be stored for a long time at ambient conditions. His group also focuses on the development of analytical devices that allow photocatalytic and electrocatalytic screening using only picomole quantities of catalysts and reagents. A third analytical innovative development by the Badu-Tawiah research group is multi-mode contained electrospray ionization (ESI) apparatus that enables (i) the elimination of ion suppression effects during the stages of droplet formation in ESI (not before as in LC, and not after as in tandem MS – although these can be combined with our approach in a single experiment) by seeding reactive vapors in the droplet environment and (ii) high throughput proteomics via online cross-linking, charge reduction, and supper charging of analytes eluting from an LC column. Within three and a half years of work as Assistant Professor, this research has resulted in more than 17 peer-reviewed publications, 16 invited talks and conference presentations, and several (provisional) patents. Dr. Badu-Tawiah received a Research Award from the American Society for Mass Spectrometry (2017), Early Career Award from the Department of Energy (2016), and Eli Lilly Young Investigator Award in Analytical Chemistry (2017). He also has been named as Emerging Investigator by the Analyst and the Journal of the American Society for Mass Spectrometry. He served as co-organizer of the “Gaseous Ion Chemistry and Surface Reactions” symposium during the Fall 2017 National ACS Meeting in Washington, DC. He has also served as session chairs in several conferences including FACSS/SCIX 2017 and 2017 ion chemistry Gordon Conference.