Ohio State Navbar

Research Activities

Biofilms in Human Medicine Interest Group

The goal of the Biofilms in Human Medicine  Interest Group is to define the critical factors that facilitate bacterial biofilm development in human disease and then use this knowledge to develop therapies to prevent initial infection or progression to persistent biofilms (i.e. chronic and/or persistent disease).


Biofilms, which are communities of microorganisms that are attached to a surface, play a critical role in numerous infectious diseases. The CDC and the NIH recently estimated that biofilms are responsible for 65% to 80% of all infections. In 2008, The CMIB established a multi-disciplinary translational biofilms research group that consists of microbiologists, immunologists, biochemists, pathologists, computational biologist, and infectious disease experts, as well as pulmonary and otolaryngology specialists. The team meets monthly to discuss scientific and programmatic themes with the goal to submit an NIH program project grant. The human diseases represented by the projects include cystic fibrosis, chronic gastrointestinal disease, chronic otitis media and sinusitis, dental caries, infection of the genitourinary tract, periodontitis, and device related infections. Those participating include scientists and clinicians from OSU (infectious disease, dentistry, oral biology, orthopedics, microbiology, DHLRI, and FAES) as well as Nationwide Children's Hospital and Battelle Memorial Institute.

Click to download high resolution logo

Current Opportunities

1. Trainee Travel award

2. Other Trainee support



Participating CMIB Faculty


Daniel Wozniak, PhD

MI&I, Microbiology, ID, OSU

Brian Ahmer, PhD

Microbiology, OSU

Amal Amer, MD, PhD


Michael Bailey, PhD

Oral Biology, OSU

Lauren Bakaletz, PhD

Pediatrics, Otolaryngology, NCH

Jennifer Edwards, PhD

Pediatrics, NCH

Steven Goodman, PhD

Pediatrics, NCH

Ann Griffen, DDS, MS

Pediatric Dentistry, OSU

John Gunn, PhD

MI&I, Microbiology, ID, OSU

Luanne Hall-Stoodley, PhD


Sheryl Justice, PhD

Pediatrics, NCH

Eugene Leys, PhD

Oral Biology, OSU

Kevin Mason, PhD

Pediatrics, NCH

Robert Munson, PhD

Microbiology, Pediatrics, MVIMG, NCH

Abigail Norris Turner, PhD

COPH, Divison of Epidemiology, ID OSU

Vijay Pancholi, PhD

Pathology, MI&I, OSU

Paul Stoodley, PhD

MI&I, Orthopaedics, OSU

Hua Wang, PhD

Food Science & Technology, Microbiology, OSU


Participating non-CMIB Faculty


Cliff Beall, PhD

Dentistry, OSU

David Hesse

Battelle Memorial Institute

Mark Klebanoff, MD, MPH

Medicine, NCH

Purnima Kumar, PhD

Peridontology, OSU

Jiyoung Lee

COPH, Environmental Health Sciences, OSU

Steven Lower, PhD

Earth Sciences, School of Environment & Natural Resources, OSU

Sashwati Roy, PhD

Dept of Surgery, OSU

Michael Triplett, PhD

N8 Medical

MI&I: Department of Microbial Infection and Immunity
ID: Department of Internal Medicine, Division of Infectious Diseases
PACS: Department of Internal Medicine, Division of Pulmonary, Allergy, Critical Care & Sleep Medicine
MVIMG: Department of Molecular Virology, Immunology & Medical Genetics
COPH: College of Public Health
OSU: The Ohio State University
NCH: Nationwide Children's Hospital



Registration Open: Biofilms 6 Vienna (May 11-13, 2014


CTW: Biofilms in Infectious Disease: Biology to Mathematical Models and Back Again (March 22-25, 2010)

Cosponsored with Ohio State University Medical School
John Gunn, Dan Wozniak, and Nick Cogan

Monthly meeting schedule: First Wednesday of each month, 9:00 am


Group Location
09/03/2014 Kevin Mason Lab 130 BRT
10/01/2014 Steven Lower Lab 130 BRT
11/05/2014 Ellen Gawalt (Duquesne) 165 DHLRI
12/03/2014 Alex Rickard (Michigan) 130 BRT
01/07/2015 John Gunn 130 BRT
02/04/2015 Sheryl Justice 105 BRT
03/04/2015 Kumar Lab 159 DHLRI
04/01/2015 Wozniak Lab 105 BRT
05/06/2015 Hoet Lab 105 BRT



  • Novotny, L.A., Clements, J.D., Bakaletz, L.O. (2013).  Kinetic analysis and evaluation of the mechanisms involved in the resolution of experimental nontypeable Haemophilus influenzae-induced otitis media after transcutaneous immunization.  Vaccine, 31(34):3417-3426.  PMCID: PMC3578125.
  • Brandstetter, K.A., Jurcisek, J.A., Goodman, S.D., Bakaletz, L.O., Das, S. (2013).  Antibodies directed against integration host factor mediate biofilm clearance from Nasopore®.  Laryngoscope, 123(11):2626-2632.
  • Novotny, L.A., Amer, A.O., Goodman, S.D., Bakaletz, L.O. (2013).  Structural stability of Burkholderia cenocepacia biofilms is reliant on eDNA structure and presence of a bacterial nucleic acid binding protein.  PLoS One, 8(6):e67629.  PMCID:PMC3682984.
  • Abu Khweek, A., Fernandez Davila, N., Caution, K., Akhter, A., Abdulrahman, B., Tazi, M., Hassan, H., Novotny, L.A., Bakaletz, L.O., Amer, A.O. (2013).  Biofilm-derived Legionella pneumophila evades the innate immune response in macrophages.  Front Cell Infect Microbiol, 27(3):18.  PMCID:PMC3664316.
  • Gustave, J.E., Jurcisek, J.A., McCoy, K.S., Goodman, S.D., Bakaletz, L.O.  (2013). Targeting bacterial integration host factor to disrupt biofilms associated with cystic fibrosis. J Cystic Fibrosis, 12(4):384-389. PMCID: PMC3582735.
  • Jones, E.A., McGillivary, G., Bakaletz, L.O. (2013).  Extracellular DNA with a nontypeable Haemophilus influenzae induced biofilm serves as a sink for cationic host defense peptides.  J Innate Immun, 5(1):24-38.  PMCID: PMC3640559.
  • Brockson, M.E., Jurcisek, J.A., McGillivary, G., Bowers, M.R., Bakaletz, L.O. (2012).  Respiratory syncytial virus promotes Moraxella catarrhalis-induced ascending experimental otitis media.  PLoS One, 7(6):e40088.  PMCID:PMC3387005.
  • Bakaletz, L.O. (2012).  Bacterial biofilms in the airway – evidence for role in pathology and implications for treatment.  Paediatr Respir Rev, 13(3):154-159.  PMCID:PMC3509202.
  • Christian M. Harding, Erin N. Tracy, Michael D. Carruthers, Philip N. Rather, Luis A. Actis, Robert S. Munson, Jr.  Acinetobacter baumannii Strain M2 Produces Type IV Pili Which Play a Role in Natural Transformation and Twitching Motility but Not Surface-Associated Motility. mBio, July/August 2013; 4(4): e00360-13.

  • Lower SK, Lamlertthon S, Casillas-Ituarte NN, Lins RD, Yongsunthon R, Taylor ES, DiBartola AC, Edmonson C, McIntyre LM, Reller LB, Que YA, Ros R, Lower BH, Fowler VG Jr. Polymorphisms in fibronectin binding protein A of Staphylococcus aureus are associated with infection of cardiovascular devices. Proc Natl Acad Sci U S A. 2011 Nov 8;108(45):18372-7.

  •  Sharpe SW, Kuehn MJ, Mason KM. Elicitation of epithelial cell-derived immune effectors by outer membrane vesicles of nontypeable Haemophilus influenzae. Infect Immun. 2011 Nov;79(11):4361-9.

  • Kumar PS, Matthews CR, Joshi V, de Jager M, Aspiras M. Tobacco smoking affects bacterial acquisition and colonization in oral biofilms. Infect Immun. 2011 Nov;79(11):4730-8. Epub 2011 Aug 22.


Dr. Daniel Wozniak
1018 Biomedical Research Tower
460 W 12th Ave
Columbus, OH 43210