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Zongdi Feng, PhD


700 Children's Drive
Columbus, OH 43205

Email: feng.581@osu.edu

 

Current OSU Appointment

Assistant Professor, Pediatrics

 

Chapters in Books

Feng Z, Chen X. "Viral Infection and Cellular Apoptosis." In General Virology. Edited by Xie T, Hu Z. 177-195. Wuhan, CN|CHN: Science Publishing House, January 2002.

Feng Z, Lemon SM. "Pathogenesis of Hepatitis A Virus Infection." In The Picornaviruses: Molecular Biology, Evolution and Pathogenesis. Edited by Domingo E, Ehenfeld E, Roos R. 383-396. Washington, DC, US|USA: American Society of Microbiology Press, January 2010.

 

Degrees

1999 B.S., Wuhan University

2002 M.S., Chinese Academy of Sciences

 

Editorial Activities

2014 - present Cellular Immunology
2014 - present Journal of Clinical Microbiology
2014 - present Journal of Virology
 

Honors

2001 DIAO Graduate Fellowship. Chinese Academy of Sciences.
2009 Travel Award "Pattern Receptors and Innate Immune Signaling Pathways in Liver Diseases". The Henry M. and Lillian Stratton Basic Research Single Topic Conference.
2012 Travel Award. 31st American Society of Virology Annual Meeting.
2013 3rd place, 3rd Annual Oliver Smithies Nobel Symposium Postdoctoral Researcher Poster Forum. University of North Carolina at Chapel Hill.
2013 Best Poster Award, Center of Gastrointestinal Biology and Disease Annual Retreat. University of North Carolina at Chapel Hill.
2014 Lineberger Comprehensive Cancer Center Joseph S. Pagano Award. University of North Carolina.
2015 - present Pinnacle Research Award on Liver Diseases.. NA.
 

Journal Articles

Feng Z, Chen X, Vlak JM, Hu Z. "Sequence Analysis of the XbaI-I Region in Genome of the Single Nucleocapsid Nucleopolyhedrovirus of Helicoverpa armigera." Virologica Sinaca. Vol. 17, no. 2. (January 2002.): 125-131.

Lu Y, Feng Z, Wu D, Yuan L, Hu Z. "Study of Foreign Baculoviral ctl Gene by Overexpression Using AcMNPV Bacmid System in vivo." Virologica Sinaca. Vol. 19, no. 3. (January 2004.): 276-280.

Cheng G, Feng Z and He B. "Herpes Simplex Virus 1 Activates PERK and Blocks ER Stress Induced Translation Inhibition Through gamma(1)34.5 Protein.." J Virol. Vol. 79, no. 3. (February 2005.): 1379-88.

He F, Wang X, He B, Feng Z, Lu, Zhang Y, Zhao S, Lin R, Hui Y, Bao Y, Zhang Z and Wen H. "Human Herpesvirus 8: Seroprevalence and Correlates in Tumor Patients from Xinjiang of China.." J Med Virol. Vol. 79, no. 2. (February 2007.): 161-6.

Feng,Zongdi; Cerveny,Melissa; Yan,Zhipeng; He,Bin. "The VP35 protein of Ebola virus inhibits the antiviral effect mediated by double-stranded RNA-dependent protein kinase PKR." JOURNAL OF VIROLOGY. Vol. 81, no. 1. (January 2007.): 182-192.

Jin,Huali; Ma,Yijie; Prabhakar,Bellur,S; Feng,Zongdi; Valyi-Nagy,Tibor; Yan,Zhipeng; Verpooten,Dustin; Zhang,Cuizhu; Cao,Youjia; He,Bin. "The gamma(1)34.5 Protein of Herpes Simplex Virus 1 Is Required To Interfere with Dendritic Cell Maturation during Productive Infection." JOURNAL OF VIROLOGY. Vol. 83, no. 10. (May 2009.): 4984-4994.

Verpooten,Dustin; Feng,Zongdi; Valyi-Nagy,Tibor; Ma,Yijie; Jin,Huali; Yan,Zhipeng; Zhang,Cuizhu; Cao,Youjia; He,Bin. "Dephosphorylation of eIF2 alpha Mediated by the gamma(1)34.5 Protein of Herpes Simplex Virus 1 Facilitates Viral Neuroinvasion." JOURNAL OF VIROLOGY. Vol. 83, no. 23. (December 2009.): 12626-12630.

Stavrou,Spyridon; Feng,Zongdi; Lemon,Stanley,M; Roos,Raymond,P. "Different Strains of Theiler's Murine Encephalomyelitis Virus Antagonize Different Sites in the Type I Interferon Pathway." JOURNAL OF VIROLOGY. Vol. 84, no. 18. (September 2010.): 9181-9189.

Jin,Huali; Yan,Zhipeng; Prabhakar,Bellur,S; Feng,Zongdi; Ma,Yijie; Verpooten,Dustin; Ganesh,Balaji; He,Bin. "The VP35 protein of Ebola virus impairs dendritic cell maturation induced by virus and lipopolysaccharide." JOURNAL OF GENERAL VIROLOGY. Vol. 91, (February 2010.): 352-361.

Qu,Lin; Feng,Zongdi; Yamane,Daisuke; Liang,Yuqiong; Lanford,Robert,E; Li,Kui; Lemon,Stanley,M. "Disruption of TLR3 Signaling Due to Cleavage of TRIF by the Hepatitis A Virus Protease-Polymerase Processing Intermediate, 3CD." PLOS PATHOGENS. Vol. 7, no. 9. (September 2011.): e1002169-.

Lanford,Robert,E; Feng,Zongdi; Chavez,Deborah; Guerra,Bernadette; Brasky,Kathleen,M; Zhou,Yan; Yamane,Daisuke; Perelson,Alan,S; Walker,Christopher,M; Lemon,Stanley,M. "Acute hepatitis A virus infection is associated with a limited type I interferon response and persistence of intrahepatic viral RNA." PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. Vol. 108, no. 27. (July 2011.): 11223-11228.

Zhou,Yan; Callendret,Benoit; Xu,Dan; Brasky,Kathleen,M; Feng,Zongdi; Hensley,Lucinda,L; Guedj,Jeremie; Perelson,Alan,S; Lemon,Stanley,M; Lanford,Robert,E; Walker,Christopher,M. "Dominance of the CD4(+) T helper cell response during acute resolving hepatitis A virus infection." JOURNAL OF EXPERIMENTAL MEDICINE. Vol. 209, no. 8. (July 2012.): 1481-1492.

Feng,Zongdi; Hensley,Lucinda; McKnight,Kevin,L; Hu,Fengyu; Madden,Victoria; Ping,Lifang; Jeong,Sook-Hyang; Walker,Christopher; Lanford,Robert,E; Lemon,Stanley,M. "A pathogenic picornavirus acquires an envelope by hijacking cellular membranes." NATURE. Vol. 496, no. 7445. (April 2013.): 367-71.

Feng,Zongdi; Lemon,Stanley,M. "Peek-a-boo: membrane hijacking and the pathogenesis of viral hepatitis." TRENDS IN MICROBIOLOGY. Vol. 22, no. 2. (February 2014.): 59-64.

McGivern,David,R; Masaki,Takahiro; Williford,Sara; Ingravallo,Paul; Feng,Zongdi; Lahser,Frederick; Asante-Appiah,Ernest; Neddermann,Petra; De Francesco,Raffaele; Howe,Anita,Y; Lemon,Stanley,M. "Kinetic Analyses Reveal Potent and Early Blockade of Hepatitis C Virus Assembly by NS5A Inhibitors." GASTROENTEROLOGY. Vol. 147, no. 2. (August 2014.): 453-62.

Feng Z, Hirai-Yuki A, McKnight KL and Lemon SM. "Naked Viruses that Aren’t Always Naked: Quasi-enveloped Agents of Acute Hepatitis." Ann. Rev. Virol.. Vol. 1, (November 2014.): 539-560.

Yin,Xin; Feng,Zongdi. "Dissecting cellular entry mechanisms by enveloped and nonenveloped hepatitis E virus." HEPATOLOGY. Vol. 62, (October 2015.): 1039A-1039A.

Walker,Christopher,M; Feng,Zongdi; Lemon,Stanley,M. "Reassessing immune control of hepatitis A virus." CURRENT OPINION IN VIROLOGY. Vol. 11, (April 2015.): 7-13.

Feng,Zongdi; Li,You; McKnight,Kevin,L; Hensley,Lucinda; Lanford,Robert,E; Walker,Christopher,M; Lemon,Stanley,M. "Human pDCs preferentially sense enveloped hepatitis A virions." JOURNAL OF CLINICAL INVESTIGATION. Vol. 125, no. 1. (January 2015.): 169-176.

Yin X, Ambardekar C, Lu Y, Feng Z. "J Virol." Distinct Entry Mechanisms for Nonenveloped and Quasi-Enveloped Hepatitis E Viruses.. Vol. 90, no. 8. (March 2016.): 4232-42.

Borg BB, Feng Z, Earl TM, Anderson CD. "Clin Transplant." Hepatitis E in post-liver transplantation: is it time to routinely consider it?. Vol. 30, no. 9. (September 2016.): 975-9.

Yin X, Li X, Feng Z. "Viruses." Role of Envelopment in the HEV Life Cycle. Vol. 8, no. 8. (August 2016.): E229-.

Feng Z. "Live Int.." Causation by HEV of extrahepatic manifestations remains unproven.. Vol. 36, no. 4. (April 2016.): 477-9.

Feng Z*, Li Y, Hensley L, Lanford RE, Walker CM, Lemon SM*.. "Preferential Sensing of Enveloped Hepatitis A Virions by Human pDCs.." J. Clin. Invest.. -.

 

Reference Works

January 2011 Lanford RE, Feng Z, Chavez D, Guerra B, Brasky KM, Zhou Z, Yamane D, Walker CM, Lemon SM.."18th Int'l Symposium on Hepatitis C Virus and Related Viruses." Seattle.
January 2012 Feng Z, Lemon SM.."European Study Group on the Molecular Biology of Picornaviruses (Europic)." Sanit Raphael.
December 2013 Feng Z, McKnight KL, Hirai-Yuki A, Hu F, Lemon SM.."HEP DART 2013" Big Island.
January 2014 Lovell W, Masaki T, Feng Z, Hamlett C, Saalau-Bethell S, Graham B, McGivern D.."21st Int'l Symposium on Hepatitis C and Related Viruses" Banff.

Presentations

"12. Interference of Host Interferon Responses By Ebola Virus VP35 Protein." Presented at Chicago Area Virology Association Symposium (CAVA), Chicago. (January 2008)

"9. Modulation of Host Innate Response By The Ebolavirus VP35 Protein." Presented at University of Texas Medical Branch, Galveston. (January 2008)

"8. Modulation of Host Innate Response By The Ebolavirus VP35 Protein." Presented at University of Miami, Miami. (January 2008)

"9. Modulation of Host Innate Response By The Ebolavirus VP35 Protein." Presented at Loyola University, Chicago. (January 2008)

"9. Modulation of Host Innate Response By The Ebolavirus VP35 Protein." Presented at National Institute of Environmental Health Sciences, Durham. (January 2008)

"An NALP3 Inflammasome Response Induced by Hepatitis A Virus." Presented at AASLD single topic meeting, Atlanta. (January 2009)

"Disruption of TLR-3 Response by Hepatitis A Virus." Presented at AASLD Single Topic Conference, Atlanta. (January 2009)

"L Protein of Theiler’s Virus." Presented at 16th Meeting of the European Study Group on the Molecular Biology of Picornaviruses (EUROPIC), St. Andrews, GB|GBR. (January 2010)

"Inhibition of TLR3 Antiviral Signaling by the Hepatitis A Virus 3CD Protease-polymerase Precursor." Presented at 29th American Society of Virology Annual Meeting, Bozeman. (January 2010)

"11. Exosomes Mediated Activation of Plasmacytoid Dendritic Cells." Presented at Virology in Progress, Chapel Hill. (January 2011)

"Discovery of An Enveloped Picornavirus." Presented at Flavigroup Meeting, Durham. (January 2012)

"Plasmacytoid Dendritic Cell Activation by Exosomal Transfer of Viral RNA." Presented at Keystone Symposium, Keystone. (January 2012)

"Activation of Plasmacytoid Dendritic Cells by Exosome-like Nanovesicles Secreted From Picornavirus Infected Cells." Presented at 31st American Society of Virology Annual Meeting, Madison. (January 2012)

"Discovery of A Novel Host-Enveloped Hepatovirus." Presented at 31st American Society of Virology Annual Meeting, Madison. (January 2012)

"Membrane Hijacking and the Pathogenesis of Viral Hepatitis." Presented at Pennsylvania State University, Hershey. (December 2013)

"Mechanism of Action of An Allosteric NS3 Inhibitor." Presented at HEP DART, Big Island. (December 2013)

"Contrasting Mechanisms of Entry and Antibody-mediated Neutralization of Enveloped and Nonenveloped Hepatitis A Virus." Presented at Keystone Symposium, Boston. (January 2013)

"Membrane Hijacking: Biogenesis of Enveloped Hepatoviruses and their Role in Pathogenesis of Hepatitis A." Presented at 3rd Annual Oliver Smithies Nobel Symposium Postdoctoral Researcher Poster Forum, Chapel Hill. (January 2013)

"A Pathogenic Picornavirus Acquires an Envelope by Hijacking Cellular Membrane." Presented at 39th Lineberger Cancer Center Postdoc-faculty Research Day, Chapel Hill. (January 2014)

"5. Membrane Hijacking and the Pathogenesis of Viral Hepatitis." Presented at Child Health Research Center Seminar Series, Columbus. (January 2014)

"Quasi-enveloped Viruses: New Questions for the Virologists and the Immunologists?." Presented at Ohio Virology Association, Columbus. (November 2014)

"Immune Evasion by Hepatitis A Virus." Presented at RNA Virus Seminar, Columbus. (January 2014)

"Catch Me If You Can: Intracellular Neutralization of Enveloped Hepatitis Viruses." Presented at 1st Symposium on Molecular Aspects in Virology, Mexico City. (October 2014)