Ohio State Navbar

People

Yusen Liu, PhD


700 Childrens Dr
RB III
Columbus, OH 43205

Phone: (614) 355-6728

Email: liu.562@osu.edu

 

Current OSU Appointment

Professor, Pediatrics

 

Advising Narrative

Mary Presented her studies in Ohio Valley Toxicology conference in 2003. She learned concepts of signal transduction and performed kinase assays. Her data was presented to the society of pediatric research in 2004 as a platform presentation Ben has worked in my laboratory to learn phenotyping techniques.

Chapters in Books

Holbrook, N.J., Liu, Y., and Fornace, Jr., A.J.. "Signalling events controlling the molecular response to genotoxic stress.." In Stress-induced cellular responses.. Vol. 77. Edited by Feige U., Morimoto, R.I., Yahara, I., and Polla B.S.. 273-288. Basel, CH|CHE: Birkhauser Verlag, January 1996.

Liu, Y., Gorospe, M., Holbrook, N.J., and Anderson, C.. "Post-translational mechanisms leading to mammalian gene activation in response to genotoxic stress.." In DNA Damage and Repair, Vol. 2: DNA Repair in Higher Eukaryotes. Vol. 2. Edited by Hoekstra, M.F. and Nickoloff, J.A. 263-298. Totowa, NJ, US|USA: Humana Press, January 1998.

Liu, Y., Holbrook, N.J., Kokkonen, G.C., and Roth, G.S.. "Intracellular signal transduction and receptor activity in stimulated hepatocyte DNA synthesis.." In Methods in Aging Research. Edited by Yu, B.P.. 515-532. Boston, MA, US|USA: CRC Press, January 1998.

Liu, Y. and Holbrook, N.J.. "Mitogen-activated protein kinase signaling pathways and aging.." In Handbook of the Biology of Aging. 5th ed. Edited by E. J. Masoro & S. Austad. 179-206. San Diego, CA, US|USA: Academic Press, January 2001.

 

Degrees

1983 B.S., Zhejiang University

1986 M.S., Dalian University of Technology

1991 Ph.D., Hiroshima University

 

Editorial Activities

present Proceedings of The National Academy of Sciences
present Journal of Experimental Medicine
present Journal of Biological Chemistry
present Journal of American Aging Association
present Immunobiology
present EMBO Journal
present Critical Care Medicine
present Cellular Immunology
present Biochimica Biophysica Acta
present American Journal of Respiratory Cell and Molecular Biology
present Acta Biochimica et Biophysica Sinica
present Toxicology and Applied Pharmacology
present Protein Expression and Purification
present Molecular Biology of the Cell
present Molecular and Cellular Endocrinology
present Journal of Dental Research
present Journal of Cellular and Molecular Medicine
present Inflammation and Allergy-Drug Targets
present Expert Review of Dermatology
present Experimental Cell Research
present Circulation Research
present Chromasoma
present Cancer Research
present Cancer Letters
present Blood
present Oncogene
present Journal of Immunology
present Journal of Gerontology
2008 - present International Journal of Clinical and Exprimental Medicine
2008 - present Inflammation and Allergy - Drug Targets
2008 - present American Journal of Translational Research
2010 - present Life Sciences
 

Honors

1987 - 1991 Japanese Government Scholarship. Ministry of Education, Culture and Science of Japan.
1992 - 1995 Fogarty Fellowship. National Institutes of Health.
2000 Samuel Goldstein Distinguished Publication Award. Gerontological Society of America.
2002 - 2003 Top 25 Downloaded Articles in 2002 by the journal of Protein Expression and Purification. Journal of "Protein Expression and Purification".
2005 Ferid Murad Award. International Society for Interferon and Cytokine Research.
 

Journal Articles

Liu,Y,S; Ohki,O; Azuma,Y; Tachikawa,T; Tsuchiya,E; Fukui,S; Miyakawa,T. "CALMODULIN AND CALMODULIN-BINDING PROTEINS OF RHODOSPORIDIUM-TORULOIDES, A BASIDIOMYCETOUS YEAST." JOURNAL OF GENERAL MICROBIOLOGY. Vol. 136, (January 1990.): 131-136.

Liu YS; Yamashita Y; Tsuchiya E; Miyakawa T. "Calmodulin-binding proteins of Saccharomyces cerevisiae.." Biochemical And Biophysical Research Communications. Vol. 166, no. 2. (January 1990.): 681-686.

Liu Y, Ohki O, Tachikawa H, Fukui S, Miyakawa T. "Calmodulin-binding proteins in Rhodosporidium toruloides-a basidiomycetous yeast.." J Gen Microbiol. Vol. 136, (January 1990.): 131-136.

Liu Y; Ishii S; Tokai M; Tsutsumi H; Ohki O; Akada R; Tanaka K; Tsuchiya E; Fukui S; Miyakawa T. "The Saccharomyces cerevisiae genes (CMP1 and CMP2) encoding calmodulin-binding proteins homologous to the catalytic subunit of mammalian protein phosphatase 2B.." Molecular & General Genetics: MGG. Vol. 227, no. 1. (May 1991.): 52-59.

Nakamura,T; Tsutsumi,H; Mukai,H; Kuno,T; Miyakawa,T. "CA2+/CALMODULIN-ACTIVATED PROTEIN PHOSPHATASE (PP2B) OF SACCHAROMYCES-CEREVISIAE - PP2B ACTIVITY IS NOT ESSENTIAL FOR GROWTH." FEBS LETTERS. Vol. 309, no. 1. (August 1992.): 103-106.

Cui Z; Mochizuki D; Matsuno Y; Nakamura T; Liu Y; Hatano T; Fukui S; Miyakawa T. "Cloning and molecular analysis of cDNA encoding a carboxymethylcellulase of the yeast Cryptococcus flavus.." Bioscience, Biotechnology, And Biochemistry. Vol. 56, no. 8. (August 1992.): 1230-1235.

Nakamura,T; Liu,Y,S; Hirata,D; Namba,H; Harada,S; Hirokawa,T; Miyakawa,T. "PROTEIN PHOSPHATASE TYPE-2B (CALCINEURIN)-MEDIATED, FK506-SENSITIVE REGULATION OF INTRACELLULAR IONS IN YEAST IS AN IMPORTANT DETERMINANT FOR ADAPTATION TO HIGH-SALT STRESS CONDITIONS." EMBO JOURNAL. Vol. 12, no. 11. (November 1993.): 4063-4071.

Nakamura T; Liu Y; Hirata D; Namba H; Harada S; Hirokawa T; Miyakawa T. "Protein phosphatase type 2B (calcineurin)-mediated, FK506-sensitive regulation of intracellular ions in yeast is an important determinant for adaptation to high salt stress conditions.." The EMBO Journal. Vol. 12, no. 11. (November 1993.): 4063-4071.

Nakamura T; Namba H; Ohmoto T; Liu Y; Hirata D; Miyakawa T. "Cloning and characterization of the Saccharomyces cerevisiae SVS1 gene which encodes a serine- and threonine-rich protein required for vanadate resistance.." Gene. Vol. 165, no. 1. (November 1995.): 25-29.

Liu Y; Gorospe M; Yang C; Holbrook NJ. "Role of mitogen-activated protein kinase phosphatase during the cellular response to genotoxic stress. Inhibition of c-Jun N-terminal kinase activity and AP-1-dependent gene activation.." The Journal Of Biological Chemistry. Vol. 270, no. 15. (April 1995.): 8377-8380.

Liu Y; Guyton KZ; Gorospe M; Xu Q; Kokkonen GC; Mock YD; Roth GS; Holbrook NJ. "Age-related decline in mitogen-activated protein kinase activity in epidermal growth factor-stimulated rat hepatocytes.." The Journal Of Biological Chemistry. Vol. 271, no. 7. (February 1996.): 3604-3607.

Guyton KZ; Liu Y; Gorospe M; Xu Q; Holbrook NJ. "Activation of mitogen-activated protein kinase by H2O2. Role in cell survival following oxidant injury.." The Journal Of Biological Chemistry. Vol. 271, no. 8. (February 1996.): 4138-4142.

Gorospe M; Liu Y; Xu Q; Chrest FJ; Holbrook NJ. "Inhibition of G1 cyclin-dependent kinase activity during growth arrest of human breast carcinoma cells by prostaglandin A2.." Molecular And Cellular Biology. Vol. 16, no. 3. (March 1996.): 762-770.

Sheikh MS; Garcia M; Zhan Q; Liu Y; Fornace AJ Jr. "Cell cycle-independent regulation of p21Waf1/Cip1 and retinoblastoma protein during okadaic acid-induced apoptosis is coupled with induction of Bax protein in human breast carcinoma cells.." Cell Growth & Differentiation: The Molecular Biology Journal Of The American Association For Cancer Research. Vol. 7, no. 12. (December 1996.): 1599-1608.

Xu Q; Liu Y; Gorospe M; Udelsman R; Holbrook NJ. "Acute hypertension activates mitogen-activated protein kinases in arterial wall.." J Clin Invest. Vol. 97, no. 2. (January 1996.): 508-514.

Liu Y; Martindale JL; Gorospe M; Holbrook NJ. "Regulation of p21WAF1/CIP1 expression through mitogen-activated protein kinase signaling pathway.." Cancer Research. Vol. 56, no. 1. (January 1996.): 31-35.

Liu Y, Guyton KZ, Gorospe M, Xu Q, Lee JC, Holbrook NJ. "Differential activation of ERK, JNK/SAPK and P38/CSBP/RK map kinase family members during the cellular response to arsenite.." Free Radic Biol Med. Vol. 21, no. 6. (January 1996.): 771-781.

Huang Y; Chan AM; Liu Y; Wang X; Holbrook NJ. "Serum withdrawal and etoposide induce apoptosis in human lung carcinoma cell line A549 via distinct pathways.." Apoptosis: An International Journal On Programmed Cell Death. Vol. 2, no. 2. (January 1997.): 199-206.

Xu Q; Fawcett TW; Gorospe M; Guyton KZ; Liu Y; Holbrook NJ. "Induction of mitogen-activated protein kinase phosphatase-1 during acute hypertension.." Hypertension. Vol. 30, no. 1 Pt 1. (July 1997.): 106-111.

Guyton KZ; Gorospe M; Wang X; Mock YD; Kokkonen GC; Liu Y; Roth GS; Holbrook NJ. "Age-related changes in activation of mitogen-activated protein kinase cascades by oxidative stress.." The Journal Of Investigative Dermatology. Symposium Proceedings / The Society For Investigative Dermatology, Inc. [And] European Society For Dermatological Research. Vol. 3, no. 1. (August 1998.): 23-27.

Chen W; Martindale JL; Holbrook NJ; Liu Y. "Tumor promoter arsenite activates extracellular signal-regulated kinase through a signaling pathway mediated by epidermal growth factor receptor and Shc.." Molecular And Cellular Biology. Vol. 18, no. 9. (September 1998.): 5178-5188.

Liu Y; Gorospe M; Kokkonen GC; Boluyt MO; Younes A; Mock YD; Wang X; Roth GS; Holbrook NJ. "Impairments in both p70 S6 kinase and extracellular signal-regulated kinase signaling pathways contribute to the decline in proliferative capacity of aged hepatocytes.." Experimental Cell Research. Vol. 240, no. 1. (April 1998.): 40-48.

Wang X; Martindale JL; Liu Y; Holbrook NJ. "The cellular response to oxidative stress: influences of mitogen-activated protein kinase signalling pathways on cell survival.." The Biochemical Journal. Vol. 333 ( Pt 2), (July 1998.): 291-300.

Hutter D; Yo Y; Chen W; Liu P; Holbrook NJ; Roth GS; Liu Y. "Age-related decline in Ras/ERK mitogen-activated protein kinase cascade is linked to a reduced association between Shc and EGF receptor.." The Journals Of Gerontology. Series A, Biological Sciences And Medical Sciences. Vol. 55, no. 3. (March 2000.): B125-B134.

Wang W; Furneaux H; Cheng H; Caldwell MC; Hutter D; Liu Y; Holbrook N; Gorospe M. "HuR regulates p21 mRNA stabilization by UV light.." Molecular And Cellular Biology. Vol. 20, no. 3. (February 2000.): 760-769.

Huang Y; Hutter D; Liu Y; Wang X; Sheikh MS; Chan AM; Holbrook NJ. "Transforming growth factor-beta 1 suppresses serum deprivation-induced death of A549 cells through differential effects on c-Jun and JNK activities.." The Journal Of Biological Chemistry. Vol. 275, no. 24. (June 2000.): 18234-18242.

Hutter D, Chen P, Barnes J, Liu Y. "Catalytic activation of mitogen-activated protein (MAP) kinase phosphatase-1 by binding to p38 MAP kinase: critical role of the p38 C-terminal domain in its negative regulation.." Biochem J. Vol. 352, no. Part 1. (November 2000.): 155-163.

Shan X; Czar MJ; Bunnell SC; Liu P; Liu Y; Schwartzberg PL; Wange RL. "Deficiency of PTEN in Jurkat T cells causes constitutive localization of Itk to the plasma membrane and hyperresponsiveness to CD3 stimulation.." Molecular And Cellular Biology. Vol. 20, no. 18. (September 2000.): 6945-6957.

Li J, Gorospe M, Hutter D, Barnes J, Keyse SM, Liu Y.. "Transcriptional induction of MKP-1 in response to stress is associated with histone H3 phosphorylation-acetylation.." Mol Cell Biol. Vol. 21, no. 23. (December 2001.): 8213-8224.

Chen P; Hutter D; Yang X; Gorospe M; Davis RJ; Liu Y. "Discordance between the binding affinity of mitogen-activated protein kinase subfamily members for MAP kinase phosphatase-2 and their ability to activate the phosphatase catalytically.." The Journal Of Biological Chemistry. Vol. 276, no. 31. (August 2001.): 29440-29449.

Tong T; Fan W; Zhao H; Jin S; Fan F; Blanck P; Alomo I; Rajasekaran B; Liu Y; Holbrook NJ; Zhan Q. "Involvement of the MAP kinase pathways in induction of GADD45 following UV radiation.." Experimental Cell Research. Vol. 269, no. 1. (September 2001.): 64-72.

Hutter D, Chen P, Li J, Barnes J, Liu Y.. "The carboxyl-terminal domains of MKP-1 and MKP-2 have inhibitory effects on their phosphatase activity.." Mol Cell Biochem. Vol. 233, no. 1-2. (April 2002.): 107-117.

Chen P, Hutter D, Liu P, Liu Y. "A mammalian expression system for rapid production and purification of active MAP kinase phosphatases.." Protein Expr Purif.. Vol. 24, no. 3. (April 2002.): 481-488.

Li J, Chen P, Sinogeeva N, Gorospe M, Wersto RP, Chrest FJ, Barnes J, Liu Y. "Arsenic trioxide promotes histone H3 phosphoacetylation at the chromatin of CASPASE-10 in acute promyelocytic leukemia cells.." J Biol Chem. Vol. 277, no. 51. (December 2002.): 49504-10.

Chen P, Li J, Barnes J, Kokkonen GC, Lee JC, Liu Y. "Restraint of proinflammatory cytokine biosynthesis by mitogen-activated protein kinase phosphatase-1 in lipopolysaccharide-stimulated macrophages.." J Immunol. Vol. 169, no. 11. (December 2002.): 6408-6416.

Rong R; He Q; Liu Y; Sheikh MS; Huang Y. "TC21 mediates transformation and cell survival via activation of phosphatidylinositol 3-kinase/Akt and NF-kappaB signaling pathway.." Oncogene. Vol. 21, no. 7. (February 2002.): 1062-1070.

Li J, Gorospe M, Barnes J, Liu Y. "Tumor promoter arsenite stimulates histone H3 phosphoacetylation of proto-oncogenes c-fos and c-jun chromatin in human diploid fibroblasts.." J Biol Chem. Vol. 278, no. 15. (April 2003.): 13183-13191.

Shepherd EG, Zhao Q, Welty SE, Hansen TN, Smith CV, Liu Y. "The function of mitogen-activated protein kinase phosphatase-1 in peptidoglycan-stimulated macrophages.." J Biol Chem. Vol. 279, no. 52. (December 2004.): 54023-54031.

Nelin LD, Chicoine LG, Reber KM, English BK, Young TL, Liu Y. "Cytokine-induced endothelial arginase expression is dependent on epidermal growth factor receptor.." Am J Respir Cell Mol Biol. Vol. 33, no. 4. (October 2005.): 394-401.

Zhao Q, Shepherd EG, Manson ME, Nelin LD, Sorokin A, Liu Y. "The role of mitogen-activated protein kinase phosphatase-1 in the response of alveolar macrophages to lipopolysaccharide: attenuation of proinflammatory cytokine biosynthesis via feedback control of p38.." J Biol Chem. Vol. 280, no. 9. (March 2005.): 8101-8108.

Zhou JY, Liu Y, Wu GS. "The role of mitogen-activated protein kinase phosphatase-1 in oxidative damage-induced cell death." Cancer Res. Vol. 66, (January 2006.): 4888-4894.

Wang Z; Xu J; Zhou J-Y; Liu Y; Wu GS. "Mitogen-activated protein kinase phosphatase-1 is required for cisplatin resistance." Cancer Research. Vol. 66, no. 17. (January 2006.): 8870-8877.

Zhao Q, Wang X, Nelin LD, Yao Y, Matta R, Manson ME, Baliga RS, Meng X, Smith CV, Bauer JA, Chang CH, Liu Y. "MAP kinase phosphatase 1 controls innate immune responses and suppresses endotoxic shock." J Exp Med. Vol. 203, no. 1. (January 2006.): 131-140.

Yao Y, Xu Q, Kown MJ, Matta R, Liu Y, Hong SC, Chang CH. "ERK and p38 MAPK signaling pathways negatively regulate CIITA gene expression in dendritic cells and macrophages." J Immunol. Vol. 177, (January 2006.): 70-76.

Stanley KP, Chicoine LG, Young TL, Reber KM, Lyons CR, Liu Y, Nelin LD. "Gene transfer with inducible nitric oxide synthase decreases production of urea by arginase in pulmonary arterial endothelial cells.." Am J Physiol Lung Cell Mol Physiol. Vol. 290, no. 2. (February 2006.): L298-L306.

Wang X, Matta R, Shen G, Nelin LD, Pei D, Liu Y. "Mechanism of triptolide-induced apoptosis: Effect on caspase activation and Bid cleavage and essentiality of the hydroxyl group of triptolide.." J Mol Med. Vol. 84, no. 5. (May 2006.): 405-415.

Zhao Q, Chen P, Manson ME, Liu Y.. "Production of active recombinant mitogen-activated protein kinases through transient transfection of 293T cells.." Protein Expr Purif. Vol. 46, no. 2. (April 2006.): 468-474.

Sweeney MC, Wang X, Park J, Liu Y, Pei D.. "Determination of the sequence specificity of XIAP BIR domains by screening a combinatorial peptide library." Biochemistry. Vol. 45, no. 49. (December 2006.): 14740-14748.

Wang X, Meng X, Kuhlman JR, Nelin LD, Nicol KK, English BK, Liu Y. "Knockout of Mkp-1 enhances the host inflammatory responses to gram-positive bacteria." Journal of Immunology. Vol. 178, no. 8. (January 2007.): 5312-5320.

Wang X, Liu Y. "Regulation of innate immune response by MAP kinase phosphatase-1." Cellular Signaling. Vol. 19, no. 7. (January 2007.): 1372-1382.

Nelin LD, Wang X, Zhao Q, Chicoine LG, Young TL, Hatch DM, English BK, Liu Y. "MKP-1 switches arginine metabolism from nitric oxide synthase to arginase following endotoxin challenge." American Journal of Physiology - Cell Physiology. Vol. 293, no. 2. (January 2007.): C632-C640.

Liu Y, Shepherd EG, Nelin LD. "MAPK phosphatases-regulating the immune response." Nature Reviews Immunology. Vol. 7, no. 3. (January 2007.): 202-212.

Hu JH, Chen T, Zhuang ZH, Kong L, Yu MC, Liu Y, Zang JW, Ge BX. "Feedback control of MKP-1 expression by p38." Cellular Signaling. Vol. 19, no. 2. (January 2007.): 393-400.

Calvert TJ, Chicoine LG, Liu Y, Nelin LD.. "Deficiency of mitogen-activated protein kinase phosphatase-1 results in iNOS-mediated hypotension in response to low-dose endotoxin.." Am J Physiol Heart Circ Physiol.. Vol. 294, no. 4. (April 2008.): H1621-H1629.

Wang Z, Cao N, Nantajit D, Fan M, Liu Y, Li JJ.. "Mitogen-activated protein kinase phosphatase-1 represses c-Jun NH2-terminal kinase-mediated apoptosis via NF-kappaB regulation.." J Biol Chem.. Vol. 283, no. 30. (July 2008.): 21011-21023.

Lu TC, Wang Z, Feng X, Chuang P, Fang W, Chen Y, Neves S, Maayan A, Xiong H, Liu Y, Iyengar R, Klotman PE, He JC.. "Retinoic acid utilizes CREB and USF1 in a transcriptional feed-forward loop in order to stimulate MKP1 expression in human immunodeficiency virus-infected podocytes.." Mol Cell Biol.. Vol. 28, no. 18. (September 2008.): 5785-5794.

Zhou X, Ferraris JD, Dmitrieva NI, Liu Y, Burg MB.. "MKP-1 inhibits high NaCl-induced activation of p38 but does not inhibit the activation of TonEBP/OREBP: opposite roles of p38alpha and p38delta.." Proc Natl Acad Sci USA. Vol. 105, no. 14. (April 2008.): 5620-5625.

Wang X, Nelin LD, Kuhlman JR, Meng X, Welty SE, Liu Y.. "The role of MAP kinase phosphatase-1 in the protective mechanism of dexamethasone against endotoxemia.." Life Sci.. Vol. 83, no. 19-20. (January 2008.): 671-680.

Chang R, Chicoine LG, Cui H, Kanagy NL, Walker BR, Liu Y, English BK, Nelin LD. "Cytokine-induced arginase activity in pulmonary endothelial cells in dependent on Src family tyrosine kinase activity." Am J Physiol Lung Cell Mol Physiol. Vol. 295, no. 4. (January 2008.): L688-697.

Ichikawa T, Zhang J, Chen K, Liu Y, Schopfer FJ, Baker PR, Freeman BA, Chen YE, Cui T.. "Nitroalkenes suppress lipopolysaccharide-induced signal transducer and activator of transcription signaling in macrophages: a critical role of mitogen-activated protein kinase phosphatase 1.." Endocrinology. Vol. 149, no. 8. (August 2008.): 4086-4094.

Frazier WJ; Wang X; Wancket LM; Li XA; Meng X; Nelin LD; Cato AC; Liu Y. "Increased inflammation, impaired bacterial clearance, and metabolic disruption after gram-negative sepsis in Mkp-1-deficient mice.." Journal Of Immunology (Baltimore, Md.: 1950). Vol. 183, no. 11. (December 2009.): 7411-.

Matta,Ranyia; Wang,Xianxi; Ge,Hui; Ray,William; Nelin,Leif,D; Liu,Yusen. "Triptolide induces anti-inflammatory cellular responses." AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH. Vol. 1, no. 3. (January 2009.): 267-282.

Matta R, Wang X, Ge H, Nelin LD, Liu Y. "Triptolide induces an anti-inflammatory cellular response." Am J Translational Res. Vol. 1, no. 3. (March 2009.): 267-282.

Wang X, Zhao Q, Matta R, Meng X, Liu X, Liu CG, Nelin LD, Liu Y. "Inducible nitric oxide synthase expression is regulated by MAP kinase phosphatase-1." J Biol Chem. Vol. 284, no. 40. (October 2009.): 27123-27134.

Liu Y and Shanley TP. "MAP kinase phosphatase-1 and septic shock." Journal of Organ Dysfunction. Vol. 5, no. 2. (January 2009.): 66-78.

Li L, Chen S-F, Liu Y. "MAP kinase phosphatase-1, a critical negative regulator of the innate immune response." Int J Cell Exp Med. Vol. 2, no. 1. (February 2009.): 48-67.

Jin Y; Calvert TJ; Chen B; Chicoine LG; Joshi M; Bauer JA; Liu Y; Nelin LD. "Mice deficient in Mkp-1 develop more severe pulmonary hypertension and greater lung protein levels of arginase in response to chronic hypoxia.." American Journal Of Physiology. Heart And Circulatory Physiology. Vol. 298, no. 5. (May 2010.): H1518-.

Chang J; Voorhees TJ; Liu Y; Zhao Y; Chang CH. "Interleukin-23 production in dendritic cells is negatively regulated by protein phosphatase 2A.." Proceedings Of The National Academy Of Sciences Of The United States Of America. Vol. 107, no. 18. (May 2010.): 8340-.

Gu B; Zhang J; Wang W; Mo L; Zhou Y; Chen L; Liu Y; Zhang M. "Global expression of cell surface proteins in embryonic stem cells.." Plos One. Vol. 5, no. 12. (December 2010.): e15795-.

Farrell MR; Rogers LK; Liu Y; Welty SE; Tipple TE. "Thioredoxin-interacting protein inhibits hypoxia-inducible factor transcriptional activity.." Free Radical Biology & Medicine. Vol. 49, no. 9. (November 2010.): 1361-.

Chicione LG; Stenger MR; Cui H; Calvert A; Evans RJ; English BK; Liu Y; Nelin LD. "Nitric oxide suppression of cellular proliferation depends on cationic amino acid transporter activity in cytokine-stimulated pulmonary endothelial cells.." American Journal Of Physiology. Lung Cellular And Molecular Physiology. Vol. 300, no. 4. (April 2011.): L596-.

Chicione,Louis,G; Stenger,Michael,R; Cui,Hongmei; Calvert,Andrea; Evans,Rebecca,J; English,B,Keith; Liu,Yusen; Nelin,Leif,D. "Nitric oxide suppression of cellular proliferation depends on cationic amino acid transporter activity in cytokine-stimulated pulmonary endothelial cells." AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY. Vol. 300, no. 4. (April 2011.): L596-L604.

Rastogi R; Du W; Ju D; Pirockinaite G; Liu Y; Nunez G; Samavati L. "Dysregulation of p38 and MKP-1 in response to NOD1/TLR4 stimulation in sarcoid bronchoalveolar cells.." American Journal Of Respiratory And Critical Care Medicine. Vol. 183, no. 4. (February 2011.): 500-.

Matta, R., Barnard, J.A., Wancket, L.M., Yan, J., Grieves, J., Frazier, W.J., Nelin, L.D., Cato, A.C.B., and Liu, Y.. "Knockout of Mkp-1 exacerbates colitis in Il-10-deficient mice.." Am. J. Physiol.-Gastr. L. Physiol.. Vol. 302, no. 11. (June 2012.): G1322-G1335.

Frazier,W,Joshua; Xue,Jianjing; Luce,Wendy,A; Liu,Yusen. "MAPK Signaling Drives Inflammation in LPS-Stimulated Cardiomyocytes: The Route of Crosstalk to G-Protein-Coupled Receptors." PLOS ONE. Vol. 7, no. 11. (November 2012.): e50071-.

Wancket,Lyn,M; Meng,Xiaomei; Rogers,Lynette,K; Liu,Yusen. "Mitogen-activated protein kinase phosphatase (Mkp)-1 protects mice against acetaminophen-induced hepatic injury.." Toxicologic pathology. Vol. 40, no. 8. (December 2012.): 1095-1105.

Vandevyver,Sofie; Dejager,Lien; Van Bogaert,Tom; Kleyman,Anna; Liu,Yusen; Tuckermann,Jan; Libert,Claude. "Glucocorticoid receptor dimerization induces MKP1 to protect against TNF-induced inflammation." JOURNAL OF CLINICAL INVESTIGATION. Vol. 122, no. 6. (June 2012.): 2130-2140.

Wancket, L.M., Frazier, W.J., and Liu, Y.. "Mitogen-activated protein kinase (MKP)-1 in immunology, physiology, and disease.." Life Sci.. Vol. 90, (January 2012.): 237-248.

Jin,Yi; Chen,Bernadette; Calvert,Thomas,J; Chicoine,Louis,G; Liu,Yusen; Nelin,Leif,D. "Chronic hypoxia decreases arterial and venous compliance in isolated perfused rat lungs: an effect that is reversed by exogenous L-arginine." AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY. Vol. 304, no. 2. (January 2013.): H195-H205.

Yan, J., Ralston, M.M., Meng, X.; Bongiovanni, K.D., Jones, A., Benndorf, R., Nelin, L.D., Rogers, L.K., Smith, C.V., and Liu, Y.. "Glutathione reductase is essential for host defense against bacterial infection.." Free Radical Biol. Med. Vol. 61C, (April 2013.): 320-332.

Lian, W., Upadhyaya, P., Liu, Y., and Pei, D.. "Screening bicyclic peptide libraries for protein-protein interaction inhibitors: Discovery of a tumor necrosis factor-alpha antagonist.." J. Am. Chem. Soc.. Vol. 135, (August 2013.): 11990-11995.

Turner-Ivey B, Manevich Y, Schulte J, Kistner-Griffin E, Jezierska-Drutel A, Liu Y, and Neumann CA.. "Role for Prdx1 as a specific sensor in redox-regulated senescence in breast cancer.." Oncogene. Vol. 32, (November 2013.): 5302-5314.

Rastogi, R., Jiang Z., Rosati R., Liu, Y., Beuret L., Charron J., and Samavati L.. "Rapamycin induces MKP-1 expression through activation of AKT and MEK/ ERK pathways.." J. Biol. Chem.. Vol. 288, (November 2013.): 33966-33977.

Turner-Ivey B, Manevich Y, Schulte J, Kistner-Griffin E, Jezierska-Drutel A, Liu Y, Neumann CA.. "Role for Prdx1 as a specific sensor in redox-regulated senescence in breast cancer.." Oncogene. -.

Zhang, Y., Leung, D.Y.M., Richers, B.N., Liu, Y., Remigio, L.K., Riches, D.W., and Goleva E.. "Vitamin D inhibits monocyte/macrophage pro-inflammatory 1 cytokine production by targeting mitogen-activated protein kinase phosphatase 1.." J. Immunol.. -.

Zhang, T., Lu, X., Arnold, P., Liu, Y., and Feng, Q.. "Mitogen-activated protein kinase phosphatase-1 inhibits myocardial tumor necrosis factor-alpha expression and improves cardiac function during endotoxemia.." Cardiovascular Res.. -.

Yan. J., Meng, X., Wancket, L.M., Lintner, K., Nelin, L.D., Chen, B., Francis, K.P., Smith, C.V., Rogers, L.K., Liu, Y.. "Glutathione reductase facilitates host defense by sustaining phagocytic oxidative burst and promoting the development of neutrophil extracellular traps.." J. Immunol.. -.

Shen. J., Chandrasekharan, U.M., Ashraf, M.Z., Long, E., Morton, R.E., Liu, Y., Smith, J.D., Dicorleto, P.E.. "Lack of MAP kinase phosphatase-1 protects ApoE-null mice against atherosclerosis.." Circ Res.. -.

Gu, B., Zhang, J., Chen, Q., Tao, B., Wang, W., Zhou, Z., Chen, R., Liu, Y., Zhang, M.. "Aire regulates the expression of differentiation-associated genes and self-renewal of embryonic stem cells.." Biochem. Biophys. Res. Commun.. -.

 

Reference Works

January 2003 Liu, Y., Miller, B.A., and Barnes, B.."Interferon-gamma augments p38 and JNK MAP kinases through blocking MKP-1 induction in lipopolysaccharide-stimulated macrophages." .
January 2003 Liu, Y., Li, J., Lorenzini, A., Sinogeeva, N., Chen, P., Gorospe, M., and Cristofalo, V.J.."Constitutively active Raf induces growth arrest in WI-38 normal human lung fibroblasts: The effects of active Raf on chromosomal structure and gene expression profiles." .
January 2003 Chen, P., Li, J., Barnes, J., Kokkonen, G.C., Lee, J.C., and Liu, Y.."Restraint of pro-inflammatory cytokine biosynthesis by MKP-1 in lipopolysaccharide-stimulated macrophages." .
January 2003 Manson, M.E., Rogers, L.K., Smith, C.V., and Liu, Y.."Overdose of acetaminophen activates c-Jun N-terminal kinases." .
January 2004 Liu, Y., Zhao, Q., Shepherd, E.G., Chen, P., and Kokkonen, GC.."Regulation of proinflammatory cytokine production by mitogen-activated protein kinase phosphatase-1 in lipopolysaccharide-stimulated macrophages." .
January 2004 Liu, Y., Li, J., Gorospe, M., and Barnes, J.."Tumor promoter arsenite stimulates histone H3 phosphoacetylation at c-fos and c-jun in normal human diploid fibroblasts." .
January 2004 Liu, L., Su, S.Y., Nowicki, P.N., Wang, X.T., and Liu, Y.."Triptolide inhibits the PI3-kinase/Akt pathway and induces apoptosis of human tumor cells." .
January 2004 Nelin, L.D., Young, T.L., Smith, C.V., and Liu, Y.."The effect of stable transfection of MKP-1 on LPS-induced nitric oxide and urea production in RAW264.7 cells." .
January 2004 Zhao, Q., Shepherd, E.G., and Liu, Y.."Induction of mitogen-activated protein kinase phosphatase-1 by anti-inflammatory corticosteroids in macrophages." .
January 2004 Zhao, Q., Shepherd, E.G., and Liu, Y.."The role of MKP-1 as a negative regulator of map kinases in LPS-stimulated alveolar macrophages." .
January 2004 Young, T.L., Chicoine , L.G., Liu, Y., and Nelin, L.D.."Genistein inhibits cytokine-induced arginase expression and urea production in pulmonary arterial endothelial cells." .
January 2004 Shepherd, E.G., Zhao, Q., Welty, S.E., Hansen, T.N., Smith, C.V. and Liu, Y.."Modulation of inflammatory signals by MAP kinase phosphatase-1 in peptidoglycan-stimulated macrophages." .
January 2004 Meng, X., Manson. M.E., Rogers, L.K., Shepherd, E.G., Smith, C.V., and Liu, Y.."Overdose of acetaminophen activates c-Jun N-terminal kinases." .
January 2005 Zhao, Q., Shepherd, E.G., Nelin, L.D., and Liu, Y.."Regulation of innate immune responses to LPS by mitogen-activated protein kinase phosphatase-1." .
January 2005 Zhao, Q., Shepherd, E.G., Manson, M.E., Nelin, L.D., Sorokin, A., and Liu, Y.."Feedback control of MAP kinases and proinflammatory cytokine biosynthesis by MKP-1 in LPS-stimulated alveolar macrophages." .
January 2005 Zhao, Q., Nelin, L.D., Manson, M.E., Shepherd, E.E., and Liu, Y.."MKP-1, a Footbrake of the Innate Immune Responses." .
January 2005 Zhao, Q., Chen, P., and Liu, Y.."Production of active recombinant MAP kinases through transient transfection of 293T cells." .
January 2005 Young, T.L., English, B.K., Chicoine, L.G., Liu, Y., and Nelin, L.."Epidermal growth factor receptor tyrosine kinase regulates cytokine-induced arginase expression in bovine pulmonary arterial endothelial cells." .
January 2005 Matta, R., Shepherd, E.G., Nelin, L.D., English, B.K., and Liu, Y.."Triptolide potently inhibits the macrophage expression of inflammatory cytokines stimulated by bacterial components." .
January 2005 Manson, M.E., Zhao, Q., Shepherd, E.G., Nelin, L.D., Sorokin, A., and Liu, Y.."MKP-1 plays an important role in the attenuation of MAP kinase activation and TNF- production induced by LPS in alveolar macrophages." .
January 2005 Chicoine, L.G., Rieger-Fackeldey, E., Young, T.L., Liu, Y., and Nelin, N.D.."Cytokine-induced nitric oxide is due mainly to inducible nitric oxide synthase in bovine pulmonary arterial endothelial cells." .
January 2005 Wang, X., Matta, R., Shen, G., Pei, D., and Liu, Y.."The hydroxyl group at position 14 is essential for the anti-cancer and anti-inflammatory activities of triptolide." .
January 2005 Liu, Y., Shepherd, E.G., Zhao, Q., Welty, S.E., Hansen, T.N., Smith, C.V.."The function of mitogen-activated protein kinase phosphatase-1 in peptidoglycan-stimulated macrophages." .
January 2005 Su, B.Y., Liu, Y., and Nowicki, P.T.."The anti-apoptotic protein Bcl-2 inhibits apoptosis of vascular smooth muscle cells induced by mechanical stretch." .
January 2005 Nowicki, P.T., Liu, Y., and Wang, X.."Lipopolysaccharide up regulates endothelin ETA receptora and downregulates ETB receptors in piglet intestine." .
January 2005 Shepherd, E.G., Zhao, Q., and Liu, Y.."Regulation of pro-inflammatory MAP kinase pathways by MKP-1 and oxidative stress in macrophages." .
January 2006 Zhao, Q., Wang, X., Nelin, L.D., Meng, X., Smith, C.V., Bauer, J.A., and Liu, Y.."MAP kinase phosphatase-1 controls innate immune responses and suppresses endotoxic shock." .
January 2006 Zhao, Q., Wang, X., Nelin, L.D., Meng, X., Smith, C.V., Bauer, J.A., and Liu, Y.."MKP-1 restrains innate immune responses and protects host from endotoxic shock." .
January 2006 Wang, X., Meng, X., Nelin, L.D., and Liu, Y.."Knockout of Mkp-1 sensitizes mice to multiple organ failure elicited by peptidoglycan and lipoteichoic acid." .
January 2006 Wang, X., Kuhlman, K., Meng, X., and Liu, Y.."MAP kinase phosphatase (MKP)-1 plays an important role in the anti-inflammatory action of glucocorticoids." .
January 2006 Kuhlman, J.R., Wang, X., Zhao, Q., Nelin, L.D., and Liu, Y.."Regulation of acute-phase response by MKP-1." .
January 2006 Lin, T.K., Barnard, J.A., Liu, Y.."The Role of Mitogen-activated Protein Kinase Phosphatase-1 in a Mouse Model of Inflammatory Bowel Disease." .
January 2007 Wang, X., Nelin, L.D., Kuhlman, J.R., Meng, X., Welty, S.E., and Liu, Y.."MAP kinase phosphatase-1 plays a pivotal role in the protective effect of dexamethasone against endotoxic shock." .
January 2007 Wang, X., Nelin, L.D., Kuhlman, J.R., Meng, X., Welty, S.E., and Liu, Y."MAP kinase phosphatase-1 plays a pivotal role in the protective effect of dexamethasone against endotoxic shock." .
January 2007 Wang, X., Meng, X., Kuhlman, J.R., Nelin, L.D., English, B.K., Liu, Y.."Knockout of Mkp-1 enhances the host inflammatory responses to Gram-positive bacteria." .
January 2007 Liu, Y. Wang, X., Meng, X., Kuhlman, J.R., Nelin, L.D., English, B.K.."Knockout of Mkp-1 enhances the host inflammatory responses to Gram-positive bacteria." .
January 2008 Shen, J., Chandrasekharan, U.M., Liu, Y., Smith, J.D., and DiCorleto, P.E.."MAP kinase phosphatase-1 (MKP-1) deficiency leads to reduced atherosclerotic lesion formation in ApoE-null mice" .
January 2008 Liu, Y., Zhao Q., Wang, X., Nelin, L.D.."MKP-1 inhibits iNOS expression during the innate immune response to LPS." .
January 2009 W. Joshua Frazier, Xianxi Wang, Xiaomei Meng, Leif D. Nelin, Yusen Liu."Increased inflammation, impaired bacterial clearance, and metabolic disruption after Gram-negative sepsis in Mkp-1 deficient mice" .
January 2009 Frazier, WJ, Wang, X., Wancket, L.M., Meng, X., Nelin, L.D., and Liu, Y.."Increased inflammation, impaired bacterial clearance, and metabolic disruption after Gram-negative sepsis in Mkp-1 deficient mice" .
January 2009 Ranyia Matta, John Barnard, Lyn M. Wancket, Jessica Grieves, Qingqing Wang, Yi Jin, Leif, D. Nelin, and Yusen Liu."ROLE OF MKP-1 IN AN IL-10 KNOCKOUT MURINE MODEL OF INFLAMMATORY" .
May 2012 Talavera, M., Jin, Y., Hackam, D., Liu, Y., and Nelin, L.D.."The role of mitogen-activated protein kinase phosphatase-1 in a murine model of necrotizing enterocolitis" Bethesda.
May 2013 Yan G, Ralston MM, Meng X, Bongiovanni KD, Jones AL, Benndorf R, Nelin LD, Frazier WJ, Rogers LK, Smith CV, Liu Y."Glutathione Reductase (Gsr) Is Essential for Host Defense against Bacterial Infection" Bethesda.
May 2013 YusLiu Y, Xue J, Shakibi Y, Xu P, Wancket LM, Nelin LD, and Frazier WJ."ERK MAP Kinases Are Critical for the Expression of MKP-1 and MKP-2 in Macrophages Following LPS Stimulation" Bethesda.
May 2013 Nelin, L.D., Cui, C., Chen, B., Chicoine, L.G., and Liu, Y."Oxygen Tension Regulates Arginase II Expression in Human Pulmonary Endothelial Cells via Hypoxia-Inducible Factor 2α" Bethesda.
May 2013 YuLiu Y, Xue J, Shakibi Y, Xu P, Wancket LM, Nelin LD, and Frazier WJ."Regulation of the Expression of MKP-1 and MKP-2 by ERK MAP Kinases in Macrophages Following LPS Stimulation" Bethesda.

Professional Activities

1999 - present Invited Speaker at the Annual Scientific Meeting of the American Aging Society, Symposium on Metabolic Mechanisms of Longevity.. American Aging Society. Seattle, WA.
2000 - present Invited speaker and award recipient at the 53st Annual Scientific Meeting of The Gerontological Society of America. The Gerontological Society of America.
2001 - present Invited Seminar. Providence College. Providence, RI.
2002 - present Invited Seminar Speaker at Lankenau Medical Research Center. Lankenau Medical Research Center. Philadelphia, PA.
2002 - present Seminar at Locus Discovery Inc.. Locus Discovery Inc.. Blue Bell, PA.
2003 - present Invited speaker at the 2003 Japanese Gerontological Society Annual Meeting. Japanese Gerontological Society.
2005 - present NIH Study Section: ZRG1 IMM-F (04)-Regulation of Cytokine Production.. NIH. Bethesda, MD.
2005 - present NIH Study Section: ZRG1 MOSS-D (13)-Small Business Rheumatology.. NIH. Bethesda, MD.
2006 - present Consultant to Humanzyme. HumanZyme Inc.. Chicago, IL.
2007 - present Seminar Speaker at the National Institute on Aging. National Institute on Aging/NIH-Intramural Research Program. Baltimore, MD.
2008 - present Speaker of the Immunology Seminar Series at Ohio State University. The Immunology Seminar Series at Ohio State University. Columbus, OH.
2009 - present In vited Speaker at the 51st Annual Scientific Meeting of The Gerontological Society of America. 51st Annual Scientific Meeting of The Gerontological Society of America. Philadelphia, PA.
2009 - present Invited Seminar Speaker. University of Illinois at Chicago School of Medicine. Chicago, IL.
2010 - present Society for Pediatric Research Annual Meeting. Society for Pediatric Research. Vancouver, BC.
2010 - present Invited seminar speaker. Medical University of South Carolina. Charleston, SC.
2010 - present AAI annual Meeting. AAI. Baltimore, MD.
2011 - present Society of Leukocyte Biology Annual Meeting. Society of Leukocyte Biology. Kansas City, MO.
2011 - present Society for Pediatrics Research Annual Meeting. Society for Pediatrics Research. Denver, CO.
2011 - present Conference Speaker. American Association of Immunologists. San Francisco, CA.
1995 Presentation at the Keystone Conference on Signal Transduction in Eukaryotic Cells.. The Keystone Conference on Signal Transduction in Eukaryotic Cells.. Keystone, CO.
2003 Ad hoc reviewer for The Wellcome Trust (UK). The Wellcome Trust (UK).
2002 - 2005 Consultation to APT Therapeutics. APT therapeutics. St Louis, MO.
2005 Ad hoc reviewer for Austrian Science Fund. Austrian Science Fund.
2005 Presentation at the 2005 annual meeting of The International Society for Interferon and Cytokine Research.. The International Society for Interferon and Cytokine Research.
2006 Presentation at the 2006 ASBMB annual meeting. ASBMB. San Francisco, CA.
2007 Talk at International Conference on Immunology 2007. International Conference on Immunology 2007.
2007 Talk at the 2007 AAI annual meeting. AAI. Miami, FL.
2008 Ad hoc reviewer for grant proposal of Wellcome Trust (UK). Wellcome Trust.
2009 Ad hoc reviewer for grant proposal of Wellcome Trust (UK). Wellcome Trust (UK).
2009 Ad hoc reviewer for grant proposal. Agency for Science, Technology, and Research's (A*STAR) Biomedical Research Council (BMRC) in Singapore.