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Yusen Liu, PhD


700 Childrens Dr
RB III
Columbus, OH 43205

Phone: (614) 355-6728

Email: liu.562@osu.edu

 

Current OSU Appointment

Professor, Pediatrics

 

Advising Narrative

Mary Presented her studies in Ohio Valley Toxicology conference in 2003.
She learned concepts of signal transduction and performed kinase assays. Her data was presented to the society of pediatric research in 2004 as a platform presentation
Ben has worked in my laboratory to learn phenotyping techniques.

Chapters in Books

Signalling events controlling the molecular response to genotoxic stress.

Post-translational mechanisms leading to mammalian gene activation in response to genotoxic stress.

Intracellular signal transduction and receptor activity in stimulated hepatocyte DNA synthesis.

Mitogen-activated protein kinase signaling pathways and aging.

 

Degrees

1983 B.S., Zhejiang University

1986 M.S., Dalian University of Technology

1991 Ph.D., Hiroshima University

 

Editorial Activities

present Proceedings of The National Academy of Sciences
present Journal of Experimental Medicine
present Journal of Biological Chemistry
present Journal of American Aging Association
present Immunobiology
present EMBO Journal
present Critical Care Medicine
present Cellular Immunology
present Biochimica Biophysica Acta
present American Journal of Respiratory Cell and Molecular Biology
present Acta Biochimica et Biophysica Sinica
present Protein Expression and Purification
present Molecular Biology of the Cell
present Molecular and Cellular Endocrinology
present Journal of Dental Research
present Journal of Cellular and Molecular Medicine
present Inflammation and Allergy-Drug Targets
present Expert Review of Dermatology
present Experimental Cell Research
present Circulation Research
present Cancer Research
present Cancer Letters
present Blood
present Oncogene
present Journal of Immunology
present Journal of Gerontology
present Chromasoma
present Toxicology and Applied Pharmacology
2008 - present International Journal of Clinical and Exprimental Medicine
2008 - present Inflammation and Allergy - Drug Targets
2008 - present American Journal of Translational Research
2010 - present Life Sciences
 

Honors

1987 - 1991 Japanese Government Scholarship. Ministry of Education, Culture and Science of Japan.
1992 - 1995 Fogarty Fellowship. National Institutes of Health.
2000 - present Samuel Goldstein Distinguished Publication Award. Gerontological Society of America.
2002 - 2003 Top 25 Downloaded Articles in 2002 by the journal of Protein Expression and Purification. Journal of "Protein Expression and Purification".
2005 - present Ferid Murad Award. International Society for Interferon and Cytokine Research.
 

Journal Articles

 

Reference Works

January 2003 Liu, Y., Miller, B.A., and Barnes, B.."Interferon-gamma augments p38 and JNK MAP kinases through blocking MKP-1 induction in lipopolysaccharide-stimulated macrophages." .
January 2003 Liu, Y., Li, J., Lorenzini, A., Sinogeeva, N., Chen, P., Gorospe, M., and Cristofalo, V.J.."Constitutively active Raf induces growth arrest in WI-38 normal human lung fibroblasts: The effects of active Raf on chromosomal structure and gene expression profiles." .
January 2003 Manson, M.E., Rogers, L.K., Smith, C.V., and Liu, Y.."Overdose of acetaminophen activates c-Jun N-terminal kinases." .
January 2003 Chen, P., Li, J., Barnes, J., Kokkonen, G.C., Lee, J.C., and Liu, Y.."Restraint of pro-inflammatory cytokine biosynthesis by MKP-1 in lipopolysaccharide-stimulated macrophages." .
January 2004 Zhao, Q., Shepherd, E.G., and Liu, Y.."The role of MKP-1 as a negative regulator of map kinases in LPS-stimulated alveolar macrophages." .
January 2004 Liu, Y., Zhao, Q., Shepherd, E.G., Chen, P., and Kokkonen, GC.."Regulation of proinflammatory cytokine production by mitogen-activated protein kinase phosphatase-1 in lipopolysaccharide-stimulated macrophages." .
January 2004 Zhao, Q., Shepherd, E.G., and Liu, Y.."Induction of mitogen-activated protein kinase phosphatase-1 by anti-inflammatory corticosteroids in macrophages." .
January 2004 Shepherd, E.G., Zhao, Q., Welty, S.E., Hansen, T.N., Smith, C.V. and Liu, Y.."Modulation of inflammatory signals by MAP kinase phosphatase-1 in peptidoglycan-stimulated macrophages." .
January 2004 Liu, Y., Li, J., Gorospe, M., and Barnes, J.."Tumor promoter arsenite stimulates histone H3 phosphoacetylation at c-fos and c-jun in normal human diploid fibroblasts." .
January 2004 Liu, L., Su, S.Y., Nowicki, P.N., Wang, X.T., and Liu, Y.."Triptolide inhibits the PI3-kinase/Akt pathway and induces apoptosis of human tumor cells." .
January 2004 Nelin, L.D., Young, T.L., Smith, C.V., and Liu, Y.."The effect of stable transfection of MKP-1 on LPS-induced nitric oxide and urea production in RAW264.7 cells." .
January 2004 Young, T.L., Chicoine , L.G., Liu, Y., and Nelin, L.D.."Genistein inhibits cytokine-induced arginase expression and urea production in pulmonary arterial endothelial cells." .
January 2004 Meng, X., Manson. M.E., Rogers, L.K., Shepherd, E.G., Smith, C.V., and Liu, Y.."Overdose of acetaminophen activates c-Jun N-terminal kinases." .
January 2005 Shepherd, E.G., Zhao, Q., and Liu, Y.."Regulation of pro-inflammatory MAP kinase pathways by MKP-1 and oxidative stress in macrophages." .
January 2005 Zhao, Q., Nelin, L.D., Manson, M.E., Shepherd, E.E., and Liu, Y.."MKP-1, a Footbrake of the Innate Immune Responses." .
January 2005 Su, B.Y., Liu, Y., and Nowicki, P.T.."The anti-apoptotic protein Bcl-2 inhibits apoptosis of vascular smooth muscle cells induced by mechanical stretch." .
January 2005 Matta, R., Shepherd, E.G., Nelin, L.D., English, B.K., and Liu, Y.."Triptolide potently inhibits the macrophage expression of inflammatory cytokines stimulated by bacterial components." .
January 2005 Zhao, Q., Shepherd, E.G., Nelin, L.D., and Liu, Y.."Regulation of innate immune responses to LPS by mitogen-activated protein kinase phosphatase-1." .
January 2005 Chicoine, L.G., Rieger-Fackeldey, E., Young, T.L., Liu, Y., and Nelin, N.D.."Cytokine-induced nitric oxide is due mainly to inducible nitric oxide synthase in bovine pulmonary arterial endothelial cells." .
January 2005 Young, T.L., English, B.K., Chicoine, L.G., Liu, Y., and Nelin, L.."Epidermal growth factor receptor tyrosine kinase regulates cytokine-induced arginase expression in bovine pulmonary arterial endothelial cells." .
January 2005 Zhao, Q., Chen, P., and Liu, Y.."Production of active recombinant MAP kinases through transient transfection of 293T cells." .
January 2005 Manson, M.E., Zhao, Q., Shepherd, E.G., Nelin, L.D., Sorokin, A., and Liu, Y.."MKP-1 plays an important role in the attenuation of MAP kinase activation and TNF- production induced by LPS in alveolar macrophages." .
January 2005 Wang, X., Matta, R., Shen, G., Pei, D., and Liu, Y.."The hydroxyl group at position 14 is essential for the anti-cancer and anti-inflammatory activities of triptolide." .
January 2005 Nowicki, P.T., Liu, Y., and Wang, X.."Lipopolysaccharide up regulates endothelin ETA receptora and downregulates ETB receptors in piglet intestine." .
January 2005 Zhao, Q., Shepherd, E.G., Manson, M.E., Nelin, L.D., Sorokin, A., and Liu, Y.."Feedback control of MAP kinases and proinflammatory cytokine biosynthesis by MKP-1 in LPS-stimulated alveolar macrophages." .
January 2005 Liu, Y., Shepherd, E.G., Zhao, Q., Welty, S.E., Hansen, T.N., Smith, C.V.."The function of mitogen-activated protein kinase phosphatase-1 in peptidoglycan-stimulated macrophages." .
January 2006 Zhao, Q., Wang, X., Nelin, L.D., Meng, X., Smith, C.V., Bauer, J.A., and Liu, Y.."MAP kinase phosphatase-1 controls innate immune responses and suppresses endotoxic shock." .
January 2006 Zhao, Q., Wang, X., Nelin, L.D., Meng, X., Smith, C.V., Bauer, J.A., and Liu, Y.."MKP-1 restrains innate immune responses and protects host from endotoxic shock." .
January 2006 Wang, X., Kuhlman, K., Meng, X., and Liu, Y.."MAP kinase phosphatase (MKP)-1 plays an important role in the anti-inflammatory action of glucocorticoids." .
January 2006 Lin, T.K., Barnard, J.A., Liu, Y.."The Role of Mitogen-activated Protein Kinase Phosphatase-1 in a Mouse Model of Inflammatory Bowel Disease." .
January 2006 Kuhlman, J.R., Wang, X., Zhao, Q., Nelin, L.D., and Liu, Y.."Regulation of acute-phase response by MKP-1." .
January 2006 Wang, X., Meng, X., Nelin, L.D., and Liu, Y.."Knockout of Mkp-1 sensitizes mice to multiple organ failure elicited by peptidoglycan and lipoteichoic acid." .
January 2007 Liu, Y. Wang, X., Meng, X., Kuhlman, J.R., Nelin, L.D., English, B.K.."Knockout of Mkp-1 enhances the host inflammatory responses to Gram-positive bacteria." .
January 2007 Wang, X., Meng, X., Kuhlman, J.R., Nelin, L.D., English, B.K., Liu, Y.."Knockout of Mkp-1 enhances the host inflammatory responses to Gram-positive bacteria." .
January 2007 Wang, X., Nelin, L.D., Kuhlman, J.R., Meng, X., Welty, S.E., and Liu, Y.."MAP kinase phosphatase-1 plays a pivotal role in the protective effect of dexamethasone against endotoxic shock." .
January 2007 Wang, X., Nelin, L.D., Kuhlman, J.R., Meng, X., Welty, S.E., and Liu, Y."MAP kinase phosphatase-1 plays a pivotal role in the protective effect of dexamethasone against endotoxic shock." .
January 2008 Liu, Y., Zhao Q., Wang, X., Nelin, L.D.."MKP-1 inhibits iNOS expression during the innate immune response to LPS." .
January 2008 Shen, J., Chandrasekharan, U.M., Liu, Y., Smith, J.D., and DiCorleto, P.E.."MAP kinase phosphatase-1 (MKP-1) deficiency leads to reduced atherosclerotic lesion formation in ApoE-null mice" .
January 2009 W. Joshua Frazier, Xianxi Wang, Xiaomei Meng, Leif D. Nelin, Yusen Liu."Increased inflammation, impaired bacterial clearance, and metabolic disruption after Gram-negative sepsis in Mkp-1 deficient mice" .
January 2009 Ranyia Matta, John Barnard, Lyn M. Wancket, Jessica Grieves, Qingqing Wang, Yi Jin, Leif, D. Nelin, and Yusen Liu."ROLE OF MKP-1 IN AN IL-10 KNOCKOUT MURINE MODEL OF INFLAMMATORY" .
January 2009 Frazier, WJ, Wang, X., Wancket, L.M., Meng, X., Nelin, L.D., and Liu, Y.."Increased inflammation, impaired bacterial clearance, and metabolic disruption after Gram-negative sepsis in Mkp-1 deficient mice" .
May 2012 Talavera, M., Jin, Y., Hackam, D., Liu, Y., and Nelin, L.D.."The role of mitogen-activated protein kinase phosphatase-1 in a murine model of necrotizing enterocolitis" .
May 2013 Nelin, L.D., Cui, C., Chen, B., Chicoine, L.G., and Liu, Y."Oxygen Tension Regulates Arginase II Expression in Human Pulmonary Endothelial Cells via Hypoxia-Inducible Factor 2α" .
May 2013 Yan G, Ralston MM, Meng X, Bongiovanni KD, Jones AL, Benndorf R, Nelin LD, Frazier WJ, Rogers LK, Smith CV, Liu Y."Glutathione Reductase (Gsr) Is Essential for Host Defense against Bacterial Infection" .
May 2013 YusLiu Y, Xue J, Shakibi Y, Xu P, Wancket LM, Nelin LD, and Frazier WJ."ERK MAP Kinases Are Critical for the Expression of MKP-1 and MKP-2 in Macrophages Following LPS Stimulation" .
May 2013 YuLiu Y, Xue J, Shakibi Y, Xu P, Wancket LM, Nelin LD, and Frazier WJ."Regulation of the Expression of MKP-1 and MKP-2 by ERK MAP Kinases in Macrophages Following LPS Stimulation" .

Professional Activities

1999 - present Invited Speaker at the Annual Scientific Meeting of the American Aging Society, Symposium on Metabolic Mechanisms of Longevity.. American Aging Society. Seattle, WA.
2000 - present Invited speaker and award recipient at the 53st Annual Scientific Meeting of The Gerontological Society of America. The Gerontological Society of America.
2001 - present Invited Seminar. Providence College. Providence, RI.
2002 - present Invited Seminar Speaker at Lankenau Medical Research Center. Lankenau Medical Research Center. Philadelphia, PA.
2002 - present Seminar at Locus Discovery Inc.. Locus Discovery Inc.. Blue Bell, PA.
2003 - present Invited speaker at the 2003 Japanese Gerontological Society Annual Meeting. Japanese Gerontological Society.
2005 - present NIH Study Section: ZRG1 IMM-F (04)-Regulation of Cytokine Production.. NIH. Bethesda, MD.
2005 - present NIH Study Section: ZRG1 MOSS-D (13)-Small Business Rheumatology.. NIH. Bethesda, MD.
2006 - present Consultant to Humanzyme. HumanZyme Inc.. Chicago, IL.
2007 - present Seminar Speaker at the National Institute on Aging. National Institute on Aging/NIH-Intramural Research Program. Baltimore, MD.
2008 - present Speaker of the Immunology Seminar Series at Ohio State University. The Immunology Seminar Series at Ohio State University. Columbus, OH.
2009 - present In vited Speaker at the 51st Annual Scientific Meeting of The Gerontological Society of America. 51st Annual Scientific Meeting of The Gerontological Society of America. Philadelphia, PA.
2009 - present Invited Seminar Speaker. University of Illinois at Chicago School of Medicine. Chicago, IL.
2010 - present Society for Pediatric Research Annual Meeting. Society for Pediatric Research. Vancouver, BC.
2010 - present Invited seminar speaker. Medical University of South Carolina. Charleston, SC.
2010 - present AAI annual Meeting. AAI. Baltimore, MD.
2011 - present Society of Leukocyte Biology Annual Meeting. Society of Leukocyte Biology. Kansas City, MO.
2011 - present Society for Pediatrics Research Annual Meeting. Society for Pediatrics Research. Denver, CO.
2011 - present Conference Speaker. American Association of Immunologists. San Francisco, CA.
1995 Presentation at the Keystone Conference on Signal Transduction in Eukaryotic Cells.. The Keystone Conference on Signal Transduction in Eukaryotic Cells.. Keystone, CO.
2003 Ad hoc reviewer for The Wellcome Trust (UK). The Wellcome Trust (UK).
2002 - 2005 Consultation to APT Therapeutics. APT therapeutics. St Louis, MO.
2005 Ad hoc reviewer for Austrian Science Fund. Austrian Science Fund.
2005 Presentation at the 2005 annual meeting of The International Society for Interferon and Cytokine Research.. The International Society for Interferon and Cytokine Research.
2006 Presentation at the 2006 ASBMB annual meeting. ASBMB. San Francisco, CA.
2007 Talk at International Conference on Immunology 2007. International Conference on Immunology 2007.
2007 Talk at the 2007 AAI annual meeting. AAI. Miami, FL.
2008 Ad hoc reviewer for grant proposal of Wellcome Trust (UK). Wellcome Trust.
2009 Ad hoc reviewer for grant proposal of Wellcome Trust (UK). Wellcome Trust (UK).
2009 Ad hoc reviewer for grant proposal. Agency for Science, Technology, and Research's (A*STAR) Biomedical Research Council (BMRC) in Singapore.