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Xin Li, PhD


1900 Coffey Rd
Columbus, OH 43210

Phone: (614) 292-6524

Email: li.1315@osu.edu

 

Current OSU Appointment

Assistant Professor, Veterinary Biosciences

 

Master/Graduate Advising

I serve on 3 Ph.D. students' dissertation committee.

Academic Advising

2010 - present Peng Wang The Ohio State University.
2011 - present Hongyan Liu The Ohio State University.
2012 - present Dipu Mohan The Ohio State University.
2012 - present Sarah Chaney The Ohio State University.
2010 - 2011 Meaghan Glowacki The Ohio State University. Graduated 2011. Ixodes scapularis and Lyme Disease in Tiverton Township, Coshocton County, Ohio
2010 - 2011 Laurie Ramos The Ohio State University.
2011 Meaghan Glowacki The Ohio State University.
 

Chapters in Books

Li X and Mobley HLT. "Bacterial pili and fimbriae." In Encyclopedia of Life Sciences. -. Chichester: John Wiley & Sons, Ltd, January 2001.

Jansen AM, Poore CA, Li X, and Mobley HLT. "Urinary tract infections caused by bacterial species other than E. coli.." In Molecular Medical Microbiology. Edited by Sussman. 1541-1548. London: Academic Press, January 2001.

 

Degrees

1993 B.S., Fudan University

1999 Ph.D., University of Maryland School of Medicine

 

Editorial Activities

2010 - present Frontiers in Cellular and Infection Microbiology
2010 - present International Journal of Acarology
2012 - present Journal of Vaccination & Immunogen Techniques
 

Honors

1994 Graduate Research Fellowship. Molecular and Cell Biology Program.
1997 Graduate Merit Award. University of Maryland School of Medicine.
1997 Student Travel Grant. American Society for Microbiology.
2005 Hulda Irene Duggan Arthritis Investigator. The Arthritis Foundation.
2008 Claflin Distinguished Scholar. Massachusetts General Hospital.
 

Journal Articles

Chang J, Li X, He X, Lu Q, Yu H, Cai W, Li C, and Zhao S. "Relationship between the structure–modified N- and C- termini–and the biological activity of TNF alpha molecule.." Yi Chuan Xue Bao. Vol. 22, (January 1995.): 329-335.

Li X, Zhao H, Geymonat L, Bahrani F, Johnson DE, and Mobley HLT. "Proteus mirabilis mannose-resistant, Proteus-like fimbriae: MrpG is located at the fimbrial tip and is required for fimbrial assembly.." Infection and Immunity. Vol. 65, no. 4. (April 1997.): 1327-1334.

Zhao H, Li X, Johnson DE, Blomfield I, and Mobley HLT. "In vivo phase variation of MR/P fimbrial gene expression in Proteus mirabilis infecting the urinary tract.." Molecular Microbiology. Vol. 23, no. 5. (March 1997.): 1009-1019.

Li X and Mobley HLT. "MrpB functions as the terminator for assembly of Proteus mirabilis mannose-resistant Proteus-like fimbriae.." Infection and Immunity. Vol. 66, no. 4. (April 1998.): 1759-1763.

Zhao H, Li X, Johnson DE, and Mobley HLT. "Identification of protease and rpoN-associated genes of uropathogenic Proteus mirabilis by negative selection in a mouse model of ascending urinary tract infection." Microbiology. Vol. 145, (January 1999.): 185-195.

Li X, Johnson DE, and Mobley HLT. "Requirement of MrpH for mannose-resistant Proteus-like fimbria-mediated hemagglutination by Proteus mirabilis." Infection and Immunity. Vol. 67, no. 6. (June 1999.): 2822-2833.

Coker C, Poore CA, Li X, and Mobley HLT. "Pathogenesis of Proteus mirabilis urinary tract infection.." Microbes and Infection. Vol. 2, no. 12. (October 2000.): 1497-1505.

Li X, Rasko DA, Lockatell CV, Johnson DE, and Mobley HLT. "Repression of bacterial motility by a novel fimbrial gene product." EMBO Journal. Vol. 20, no. 17. (September 2001.): 4854-4862.

Rasko,D,A; Phillips,J,A; Li,X; MOBLEY,H,LT. "Identification of DNA sequences from a second pathogenicity island of uropathogenic Escherichia coli CFT073: Probes specific for uropathogenic populations." JOURNAL OF INFECTIOUS DISEASES. Vol. 184, no. 8. (October 2001.): 1041-1049.

Li X, Zhao H, Lockatell CV, Drachenberg CB, Johnson DE, and Mobley HLT. "Visualization of Proteus mirabilis within the matrix of urease-induced bladder stones during experimental urinary tract infection." Infection and Immunity. Vol. 70, no. 1. (January 2002.): 389-394.

Li X, Lockatell CV, Johnson DE, and Mobley HLT. "Identification of MrpI as the sole recombinase that regulates the phase variation of MR/P fimbriae, a bladder colonization factor of uropathogenic Proteus mirabilis." Molecular Microbiology. Vol. 45, no. 3. (August 2002.): 865-874.

Li X, Lockatell CV, Johnson DE, Lane MC, Warren JW, Mobley HLT. "Development of an intranasal vaccine to prevent urinary tract infection by Proteus mirabilis." Infection and Immunity. Vol. 72, no. 1. (January 2002.): 66-75.

Li,X; Mobley,H,LT. "Vaccines for Proteus mirabilish in urinary tract infection." INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS. Vol. 19, no. 6. (June 2002.): 461-465.

Pal U, Li X, Wang T, Montgomery RR, Ramamoorthi N, Norgard M, deSilva AM, Bao F, Yang X, Pypaert M, Pradhan D, Kantor FS, Telford S, Anderson JF and Fikrig E. "TROSPA, an Ixodes scapularis receptor for Borrelia burgdorferi." Cell. Vol. 119, no. 4. (November 2004.): 457-468.

Li X, Erbe JL, Lockatell CV, Johnson DE, Jobling MG, Holmes RK and Mobley HLT. "Use of a translational fusion of the MrpH fimbrial adhesin-binding domain with the cholera toxin A2 domain, coexpressed with the cholera toxin B subunit, as an intranasal vaccine to prevent experimental urinary tract infection by Proteus mirabilis." Infection and Immunity. Vol. 72, no. 12. (December 2004.): 7306-7310.

Burall LS, Harro JM, Li X, Lockatell CV, Himpsl SD, Hebel JR, Johnson DE, Mobley HLT. "Proteus mirabilis genes that contribute to pathogenesis of urinary tract infection: identification of 25 signature-tagged mutants attenuated at least 100-fold." Infection and Immunity. Vol. 72, no. 5. (May 2004.): 2922-2938.

Xu Q, Seemanapalli SV, Lomax L, McShan K, Li X, Fikrig E, Liang FT. "Association of linear plasmid 28-1 with an arthritic phenotype of Borrelia burgdorferi." Infection and Immunity. Vol. 73, no. 11. (November 2005.): 7208-7215.

Li X, Liu X, Beck DS, Kantor FS, Fikrig E. "Borrelia burgdorferi lacking BBK32, a fibronectin-binding protein, retains full pathogenicity." Infection and Immunity. Vol. 74, (January 2006.): 3305-3313.

Li X, Pal U, Ramamoorthi N, Liu X, Desrosiers DC, Eggers CH, Anderson JF, Radolf JD, Fikrig E. "The Lyme disease agent Borrelia burgdorferi requires BB0690, a Dps homologue, to persist within ticks." Molecular Microbiology. Vol. 63, (January 2007.): 694-710.

Li X, Neelakanta G, Liu X, Beck DS, Kantor FS, Fish D, Anderson JF, Fikrig E. "The role of outer surface protein D in the Borrelia burgdorferi life cycle." Infection and Immunity. Vol. 75, no. 9. (September 2007.): 4237-4244.

Neelakanta G, Li X, Pal U, Liu X, Beck DS, DePonte K, Fish D, Kantor FS, Fikrig E. "Outer surface protein B is critical for Borrelia burgdorferi adherence and survival within Ixodes ticks." PLoS Pathogens. Vol. 3, no. 3. (March 2007.): e33-.

Hovius JW, Li X, Ramamoorthi N, van Dam AP, Barthold SW, van der Poll T, Speelman P, Fikrig E. "Coinfection with Borrelia burgdorferi sensu stricto and Borrelia garinii alters the course of murine Lyme borreliosis." FEMS Immunology and Medical Microbiology. Vol. 49, no. 2. (March 2007.): 224-234.

Pal,Utpal; Dai,Jianfeng; Li,Xin; Neelakanta,Girish; Luo,Phoebe; Kumar,Manish; Wang,Penghua; Yang,Xiuli; Anderson,John,F; Fikrig,Erol. "A differential role for BB0365 in the persistence of Borrelia burgdorferi in mice and ticks." JOURNAL OF INFECTIOUS DISEASES. Vol. 197, no. 1. (January 2008.): 148-155.

Lane MC, Li X, Pearson MM, Simms AN, Mobley HLT. "Oxygen-limiting conditions enrich for fimbriate cells of uropathogenic Proteus mirabilis and Escherichia coli.." Journal of Bacteriology. Vol. 191, no. 5. (March 2009.): 1382-1392.

Shen S, Shin JJ, Strle K, McHugh G, Li X, Glickstein LJ, Drouin EE, Steere AC. "Treg cell numbers and function in patients with antibiotic-refractory or antibiotic-responsive Lyme arthritis." Arthritis and Rheumatism. Vol. 62, no. 7. (July 2010.): 2127-2137.

Li X, McHugh G, Damle N, Sikand VK, Glickstein L, Steere AC. "Burden and viability of Borrelia burgdorferi in skin and joints of patients with erythema migrans or Lyme arthritis." Arthritis and Rheumatism. Vol. 63, no. 8. (August 2011.): 2238-2247.

Strle K, Jones K, Drouin EE, Li X, Steere AC. "Borrelia burgdorferi RST1 (OspC Type A) genotype is associated with greater inflammation and more severe Lyme disease.." The American Journal of Pathology. Vol. 178, no. 6. (June 2011.): 2726-2739.

Miura,Koshiro; Matsuo,Junji; Rahman,M,Akhlakur; Kumagai,Yumi; Li,Xin; Rikihisa,Yasuko. "Ehrlichia chaffeensis Induces Monocyte Inflammatory Responses through MyD88, ERK, and NF-kappa B but Not through TRIF, Interleukin-1 Receptor 1 (IL-1R1)/IL-18R1, or Toll-Like Receptors." INFECTION AND IMMUNITY. Vol. 79, no. 12. (September 2011.): 4947-4956.

Wang,Peng; Lutton,Anthony; Olesik,John; Vali,Hojatollah; Li,Xin. "A novel iron- and copper-binding protein in the Lyme disease spirochaete." MOLECULAR MICROBIOLOGY. Vol. 86, no. 6. (December 2012.): 1441-1451.

Petnicki-Ocwieja,Tanja; Chung,Erin; Acosta,David,I; Ramos,Laurie,T; Shin,Ok,S; Ghosh,Sanjukta; Kobzik,Lester; Li,Xin; Hu,Linden,T. "TRIF Mediates Toll-Like Receptor 2-Dependent Inflammatory Responses to Borrelia burgdorferi." INFECTION AND IMMUNITY. Vol. 81, no. 2. (February 2013.): 402-410.

Li, X, Strle, K, Wang, P, et al.. "Tick-Specific Borrelial Antigens Appear to Be Up-Regulated in American but Not European Patients with Lyme Arthritis, a Late Manifestation of Lyme Borreliosis." Journal of Infectious Diseases. -.

 

Presentations

"Lyme Disease." Presented at OSU Acrology Summer Program: Medical-Vectinary Acrology, . (June 2010)

"quantitative PCR and RT-PCR derminations of Borrelia burgdorferi DNA and RNA respectively as measures of spirochetal burden and viability in patients with erythema migrans or Lyme arthritis." Presented at 12th International Conference on Lyme Borreliosis and Other Tick-Borne Diseases, . (September 2010)

"Molecular Mechanisms underlying the Persistence of Borrelia burgdorferi, the Lyme Disease Spirochete." Presented at Center for Microbial Interface Biology, Work in Progress Seminars, . (April 2011)

"Lyme Disease." Presented at OSU Acrology Summer Program: Medical-Veterinary Acrology, . (June 2012)

"Molecular Mechanims Underlying the Persistence of Borrelia burgdorferi, the Lyme Disease Spirochete." Presented at Department of Veterinary Biosciences Seminar Series, . (April 2012)

"Living in two worlds: understanding the metal biology of the Lyme disease spirochete." Presented at Center for Microbial Interface Biology 2013 Retreat, . (April 2013)

 

Professional Activities

2011 - present Lyme disease diagnosis. Fredonia Veterinary Clinic.