W. James Waldman, PhD

Current OSU Appointments

Associate Professor, Pathology

Associate Professor, SAMP-School Allied Med Prof

Associate Professor, SBS-Molec Vir, Imm & Med Gen

Degrees

1980	M.S., The Ohio State University, Allied Medicine

1990	Ph.D., The Ohio State University, Pathology

Editorial Activities

Editorial Board

State of the Art Management of CMV Infection and Disease in Transplant Recipients.

Reviewer

Journal of Heart and Lung Transplantation.

Honors

1992	Young Investigator Travel Award.

1993	Young Investigator Travel Award.

1996	Graduate Student Teaching Award.

2000	Graduate Student Teaching Award.

Memberships

2006 - present

Elected Member. American Heart Association. Immunology and Virology Study Section

Peer Reviewed Journal Articles

Waldman, W J. 1982. Biological interactions of ultrasound. Radiologic technology. Vol. 54, no. 2.

Abdel-Nabi, H; Waldman, W, J; Hinkle, G, H; Miller, E, A; Trembath, L; Olsen, J, O; Martin, E W Jr. 1987. Comparison of L-thyroxine and a saturated solution of potassium iodide in preventing damage to the thyroid following iodine-131-labeled antibody injection. NCI monographs : a publication of the National Cancer Institute, no. 3.

Roberts, W, H; Sneddon, J, M; Waldman, J; Stephens, R E. 1989. Cytomegalovirus infection of gastrointestinal endothelium demonstrated by simultaneous nucleic acid hybridization and immunohistochemistry. Archives of pathology & laboratory medicine. Vol. 113, no. 5.

Waldman, W, J; Sneddon, J, M; Stephens, R, E; Roberts, W H. 1989. Enhanced endothelial cytopathogenicity induced by a cytomegalovirus strain propagated in endothelial cells. Journal of medical virology. Vol. 28, no. 4.

Sedmak, D, D; Roberts, W, H; Stephens, R, E; Buesching, W, J; Morgan, L, A; Davis, D, H; Waldman, W J. 1990. Inability of cytomegalovirus infection of cultured endothelial cells to induce HLA class II antigen expression. Transplantation. Vol. 49, no. 2.

Waldman, W, J; Roberts, W, H; Davis, D, H; Williams, M, V; Sedmak, D, D; Stephens, R E. 1991. Preservation of natural endothelial cytopathogenicity of cytomegalovirus by propagation in endothelial cells. Archives of virology. Vol. 117, no. 3-4.

Adams, P, W; Lee, H, S; Waldman, W, J; Sedmak, D, D; Morgan, C, J; Ward, J, S; Orosz, C G. 1992. Alloantigenicity of human endothelial cells. 1. Frequency and phenotype of human T helper lymphocytes that can react to allogeneic endothelial cells. Journal of immunology (Baltimore, Md. : 1950). Vol. 148, no. 12.

Waldman, W, J; Adams, P, W; Orosz, C, G; Sedmak, D D. 1992. T lymphocyte activation by cytomegalovirus-infected, allogeneic cultured human endothelial cells. Transplantation. Vol. 54, no. 5.

Waldman, W, J; Knight, D, A; Adams, P, W; Orosz, C, G; Sedmak, D D. 1993. In vitro induction of endothelial HLA class II antigen expression by cytomegalovirus-activated CD4+ T cells. Transplantation. Vol. 56, no. 6.

Waldman, W, J; Knight, D, A; VanBuskirk, A; Adams, P, W; Orosz, C, G; Sedmak, D D. 1993. Endothelial HLA class II induction mediated by allogeneic T cells activated by cytomegalovirus-infected cultured endothelial cells. Transplantation proceedings. Vol. 25, no. 1 Pt 2.

Adams, P, W; Lee, H, S; Waldman, W, J; Sedmak, D, D; Orosz, C G. 1994. Alloantigenicity of human endothelial cells. III. Quantitated indirect presentation of endothelial alloantigens to human helper T lymphocytes. Transplantation. Vol. 58, no. 4.

Sedmak, D, D; Guglielmo, A, M; Knight, D, A; Birmingham, D, J; Huang, E, H; Waldman, W J. 1994. Cytomegalovirus inhibits major histocompatibility class II expression on infected endothelial cells. The American journal of pathology. Vol. 144, no. 4.

Sedmak, D, D; Knight, D, A; Vook, N, C; Waldman, J W. 1994. Divergent patterns of ELAM-1, ICAM-1, and VCAM-1 expression on cytomegalovirus-infected endothelial cells. Transplantation. Vol. 58, no. 12.

Garrett, J, S; Narus, J, C; Bohnsack, J, F; Carling, D, E; Grieves, K, G; Waldman, W, J; Shaddy, R E. 1995. Effects of cytomegalovirus infection on growth factor production in endothelial cells and fibroblasts. Pediatric research. Vol. 38, no. 6.

Sedmak, D, D; Chaiwiriyakul, S; Knight, D, A; Waldmann, W J. 1995. The role of interferon beta in human cytomegalovirus-mediated inhibition of HLA DR induction on endothelial cells. Archives of virology. Vol. 140, no. 1.

Waldman, W, J; Knight, D, A; Adams, P, W; Orosz, C, G; Sedmak, D D. 1995. In vitro induction of endothelial adhesion molecule and MHC antigen expression by cytomegalovirus-activated CD4+ T cells. Transplantation proceedings. Vol. 27, no. 1.

Waldman, W, J; Knight, D, A; Huang, E, H; Sedmak, D D. 1995. Bidirectional transmission of infectious cytomegalovirus between monocytes and vascular endothelial cells: an in vitro model. The Journal of infectious diseases. Vol. 171, no. 2.

Waldman, W, J; Knight, D A. 1996. Cytokine-mediated induction of endothelial adhesion molecule and histocompatibility leukocyte antigen expression by cytomegalovirus-activated T cells. The American journal of pathology. Vol. 148, no. 1.

Hanna, A, N; Waldman, W, J; Lott, J, A; Koesters, S, C; Hughes, A, M; Thornton, D J. 1997. Increased alkaline phosphatase isoforms in autoimmune diseases. Clinical chemistry. Vol. 43, no. 8 Pt 1.

Knight, D, A; Waldman, W, J; Sedmak, D D. 1997. Human cytomegalovirus does not induce human leukocyte antigen class II expression on arterial endothelial cells. Transplantation. Vol. 63, no. 9.

Waldman, W, J; Adams, P, W; Knight, D, A; Sedmak, D D. 1997. CMV as an exacerbating agent in transplant vascular sclerosis: potential immune-mediated mechanisms modelled in vitro. Transplantation proceedings. Vol. 29, no. 1-2.

Waldman, W, J; Knight, D, A; Adams, P W. 1998. Cytolytic activity against allogeneic human endothelia: resistance of cytomegalovirus-infected cells and virally activated lysis of uninfected cells. Transplantation. Vol. 66, no. 1.

Waldman, W, J; Knight, D, A; Huang, E H. 1998. An in vitro model of T cell activation by autologous cytomegalovirus (CMV)-infected human adult endothelial cells: contribution of CMV-enhanced endothelial ICAM-1. Journal of immunology (Baltimore, Md. : 1950). Vol. 160, no. 7.

Carrodeguas, L; Orosz, C, G; Waldman, W, J; Sedmak, D, D; Adams, P, W; VanBuskirk, A M. 1999. Trans vivo analysis of human delayed-type hypersensitivity reactivity. Human immunology. Vol. 60, no. 8.

Knight, D, A; Waldman, W, J; Sedmak, D D. 1999. Cytomegalovirus-mediated modulation of adhesion molecule expression by human arterial and microvascular endothelial cells. Transplantation. Vol. 68, no. 11.

Miller, D, M; Zhang, Y; Rahill, B, M; Waldman, W, J; Sedmak, D D. 1999. Human cytomegalovirus inhibits IFN-alpha-stimulated antiviral and immunoregulatory responses by blocking multiple levels of IFN-alpha signal transduction. Journal of immunology (Baltimore, Md. : 1950). Vol. 162, no. 10.

Waldman, W, J; Knight, D, A; Blinder, L; Shen, J; Lurain, N, S; Miller, D, M; Sedmak, D, D; Williams, J, W; Chong, A S. 1999. Inhibition of cytomegalovirus in vitro and in vivo by the experimental immunosuppressive agent leflunomide. Intervirology. Vol. 42, no. 5-6.

Waldman, W, J; Knight, D, A; Lurain, N, S; Miller, D, M; Sedmak, D, D; Williams, J, W; Chong, A S. 1999. Novel mechanism of inhibition of cytomegalovirus by the experimental immunosuppressive agent leflunomide. Transplantation. Vol. 68, no. 6.

Knight, D, A; Briggs, B, R; Bennett, C, F; Harindranath, N; Waldman, W, J; Sedmak, D D. 2000. Attenuation of cytomegalovirus-induced endothelial intercellular adhesion molecule-1 mRNA/protein expression and T lymphocyte adhesion by a 2'-O-methoxyethyl antisense oligonucleotide. Transplantation. Vol. 69, no. 3.

Knight, D, A; Hejmanowski, A, Q; Dierksheide, J, E; Williams, J, W; Chong, A, S; Waldman, W J. 2001. Inhibition of herpes simplex virus type 1 by the experimental immunosuppressive agent leflunomide. Transplantation. Vol. 71, no. 1.

Waldman, W, J; Bickerstaff, A; Gordillo, G; Orosz, K; Knight, D, A; Orosz, C G. 2001. Inhibition of angiogenesis-related endothelial activity by the experimental immunosuppressive agent leflunomide. Transplantation. Vol. 72, no. 9.

Fach, Estelle; Waldman, W James; Williams, Marshall; Long, John; Meister, Richard, K; Dutta, Prabir K. 2002. Analysis of the biological and chemical reactivity of zeolite-based aluminosilicate fibers and particulates. Environmental health perspectives. Vol. 110, no. 11.

Magro, Cynthia, M; Deng, April; Pope-Harman, Amy; Waldman, W James; Bernard Collins, A; Adams, Patrick, W; Kelsey, Moira; Ross, Patrick. 2002. Humorally mediated posttransplantation septal capillary injury syndrome as a common form of pulmonary allograft rejection: a hypothesis. Transplantation. Vol. 74, no. 9.

Waldman, W James; LeClaire, Joshua, D; Knight, Deborah A. 2002. T-cell activation response to allogeneic CMV-infected endothelial cells is not prevented by ganciclovir or foscarnet: implications for transplant vascular sclerosis. Transplantation. Vol. 73, no. 2.

Eubank, Tim, D; Galloway, Michelle; Montague, Christine, M; Waldman, W James; Marsh, Clay B. 2003. M-CSF induces vascular endothelial growth factor production and angiogenic activity from human monocytes. Journal of immunology (Baltimore, Md. : 1950). Vol. 171, no. 5.

Fach, Estelle; Kristovich, Robert; Long, John, F; Waldman, W James; Dutta, Prabir, K; Williams, Marshall V. 2003. The effect of iron on the biological activities of erionite and mordenite. Environment international. Vol. 29, no. 4.

Magro, Cynthia, M; Allen, James; Pope-Harman, Amy; Waldman, W James; Moh, Patrick; Rothrauff, Susan; Ross, Patrick Jr. 2003. The role of microvascular injury in the evolution of idiopathic pulmonary fibrosis. American journal of clinical pathology. Vol. 119, no. 4.

Magro, Cynthia, M; Klinger, Dana Marshall; Adams, Patrick, W; Orosz, Charles, G; Pope-Harman, Amy, L; Waldman, W James; Knight, Deborah; Ross, Patrick Jr. 2003. Evidence that humoral allograft rejection in lung transplant patients is not histocompatibility antigen-related. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons. Vol. 3, no. 10.

Magro, Cynthia, M; Ross, Patrick Jr; Kelsey, Moira; Waldman, W James; Pope-Harman, Amy. 2003. Association of humoral immunity and bronchiolitis obliterans syndrome. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons. Vol. 3, no. 9.

Wusirika, Raghav; Ferri, Clodoveo; Marin, Mary; Knight, Deborah, A; Waldman, W James; Ross, Patrick Jr; Magro, Cynthia M. 2003. The assessment of anti-endothelial cell antibodies in scleroderma-associated pulmonary fibrosis. A study of indirect immunofluorescent and western blot analysis in 49 patients with scleroderma. American journal of clinical pathology. Vol. 120, no. 4.

Avery, R, K; Bolwell, B, J; Yen-Lieberman, B; Lurain, N; Waldman, W, J; Longworth, D, L; Taege, A, J; Mossad, S, B; Kohn, D; Long, J, R; Curtis, J; Kalaycio, M; Pohlman, B; Williams, J W. 2004. Use of leflunomide in an allogeneic bone marrow transplant recipient with refractory cytomegalovirus infection. Bone marrow transplantation. Vol. 34, no. 12.

Kristovich, Robert; Knight, Deborah, A; Long, John, F; Williams, Marshall, V; Dutta, Prabir, K; Waldman, W James. 2004. Macrophage-mediated endothelial inflammatory responses to airborne particulates: impact of particulate physicochemical properties. Chemical research in toxicology. Vol. 17, no. 10.

Shen, Y, H; Utama, B; Wang, J; Raveendran, M; Senthil, D; Waldman, W, J; Belcher, J, D; Vercellotti, G; Martin, D; Mitchelle, B, M; Wang, X L. 2004. Human cytomegalovirus causes endothelial injury through the ataxia telangiectasia mutant and p53 DNA damage signaling pathways. Circulation research. Vol. 94, no. 10.

Haynes, Lynn, D; Waldman, W James; Bushkin, Yuri; Love, Robert, B; Burlingham, William J. 2005. CMV-infected allogeneic endothelial cells initiate responder and bystander donor HLA class I release via the metalloproteinase cleavage pathway. Human immunology. Vol. 66, no. 3.

Long, John, F; Waldman, W James; Kristovich, Robert; Williams, Marshall; Knight, Deborah; Dutta, Prabir K. 2005. Comparison of ultrastructural cytotoxic effects of carbon and carbon/iron particulates on human monocyte-derived macrophages. Environmental health perspectives. Vol. 113, no. 2.

Zeng, Huasong; Waldman, W James; Yin, Deng Ping; Knight, Deborah, A; Shen, Jikun; Ma, Lianli; Meister, Gabriel, T; Chong, Anita, S; Williams, James W. 2005. Mechanistic study of malononitrileamide FK778 in cardiac transplantation and CMV infection in rats. Transplantation. Vol. 79, no. 1.

Chong, A, S; Zeng, H; Knight, D, A; Shen, J; Meister, G, T; Williams, J, W; Waldman, W J. 2006. Concurrent antiviral and immunosuppressive activities of leflunomide in vivo. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons. Vol. 6, no. 1.

Magro, Cynthia, M; Waldman, W James; Knight, Deborah, A; Allen, James, N; Nadasdy, Tibor; Frambach, Gwyn, E; Ross, Patrick; Marsh, Clay B. 2006. Idiopathic pulmonary fibrosis related to endothelial injury and antiendothelial cell antibodies. Human immunology. Vol. 67, no. 4-5.

Magro, Cynthia, M; Ross, Patrick; Marsh, Clay, B; Allen, James, N; Liff, David; Knight, Deborah, A; Waldman, W James; Cowden, Daniel J. 2007. The role of anti-endothelial cell antibody-mediated microvascular injury in the evolution of pulmonary fibrosis in the setting of collagen vascular disease. American journal of clinical pathology. Vol. 127, no. 2. (IF: 2.939)

Waldman, W James; Kristovich, Robert; Knight, Deborah, A; Dutta, Prabir K. 2007. Inflammatory properties of iron-containing carbon nanoparticles. Chemical research in toxicology. Vol. 20, no. 8. (IF: 3.162)

Williams, Courtney, R; Sykes, Jane, E; Mehl, Margo; MacLeod, Jennifer, S; Lindsay, LeAnn, L; Poland, Amy, M; Chen, Yi-Je; Kyles, Andrew, E; Waldman, W James; Gregory, Clare R. 2007. In vitro effects of the active metabolite of leflunomide, A77 1726, on feline herpesvirus-1. American journal of veterinary research. Vol. 68, no. 9. (IF: 1.241)

Zhang, Guojuan; Raghavan, Bindu; Kotur, Mark; Cheatham, Jacquelyn; Sedmak, Daniel; Cook, Charles; Waldman, James; Trgovcich, Joanne. 2007. Antisense transcription in the human cytomegalovirus transcriptome. Journal of virology. Vol. 81, no. 20. (IF: 5.341)

Magro CM; Schaefer JT; Waldman J; Knight D; Seilstad K; Hearne D. 2008. Terbinafine-induced dermatomyositis: a case report and literature review of drug-induced dermatomyositis. Journal Of Cutaneous Pathology. Vol. 35, no. 1. (January 1): 74.

Waldman WJ; Williams MV Jr; Lemeshow S; Binkley P; Guttridge D; Kiecolt-Glaser JK; Knight DA; Ladner KJ; Glaser R. 2008. Epstein-Barr virus-encoded dUTPase enhances proinflammatory cytokine production by macrophages in contact with endothelial cells: evidence for depression-induced atherosclerotic risk. Brain, Behavior, And Immunity. Vol. 22, no. 2. (February 1): 215.

Ruda-Eberenz TA; Nagy A; Waldman WJ; Dutta PK. 2008. Entrapment of ionic tris(2,2'-bipyridyl) ruthenium(II) in hydrophobic siliceous zeolite: O2 sensing in biological environments. Langmuir: The ACS Journal Of Surfaces And Colloids. Vol. 24, no. 16. (August 19): 9140.

Machesky NJ; Zhang G; Raghavan B; Zimmerman P; Kelly SL; Merrill AH Jr; Waldman WJ; Van Brocklyn JR; Trgovcich J. 2008. Human cytomegalovirus regulates bioactive sphingolipids. The Journal Of Biological Chemistry. Vol. 283, no. 38. (September 19): 26148.

Positions

1997 - 1998

Research Scientist , The Ohio State University, Pathology . Columbus, OH, United States.

1997 - 1998

Clinical Assistant Professor , The Ohio State University, Pathology . Columbus, OH, United States.

2000 - 2008

Director, The Ohio State University, Pathology Graduate Studies. Columbus, OH, United States.

2001 - 2008

Associate Professor, The Ohio State University, Medicine, Pathology. Columbus, OH, United States.

1993 - present

Assistant Professor, The Ohio State University, Pathology. Columbus, OH, United States.

1996 - present

Research Scientist, The Ohio State University, Pathology. Columbus, OH, United States.

1998 - present

Assistant Professor, The Ohio State University, Pathology. Columbus, OH, United States.