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W. James Waldman, PhD


Staff photo

333 W Tenth Avenue
Columbus, OH 43210

Phone: (614) 292-7772

Email: waldman.1@osu.edu

 

Current OSU Appointments

Associate Professor, Pathology

Associate Professor, HRS - Health & Rehab Sciences

 

Degrees

1980 M.S., The Ohio State University

1990 Ph.D., The Ohio State University

 

Editorial Activities

present State of the Art Management of CMV Infection and Disease in Transplant Recipients
present Journal of Heart and Lung Transplantation
 

Honors

1992 - present Young Investigator Travel Award.
1993 - present Young Investigator Travel Award. Third Basic Sciences Symposium, Big Sky, MT.
1996 - present Graduate Student Teaching Award. Department of Pathology.
2000 - present Graduate Student Teaching Award. Department of Pathology.
 

Journal Articles

Waldman WJ. "Biological interactions of ultrasound." Radiologic Technology. Vol. 54, no. 2. (November 1982.): 106-115.

Abdel-Nabi H, Waldman WJ, Hinkle GH, Miller EA, Trembath L, Olsen JO, Martin EW. "Comparison of L-thyroxine and a saturated solution of potassium iodide in preventing damage to the thyroid following iodine-131-labeled antibody injection.." NCI Monographs. Vol. 1, no. 3. (January 1987.): 63-66.

Roberts WH, Sneddon JM, Waldman WJ, Snyder JH, Stephens RE. "CELLULAR-LOCALIZATION OF CMV INFECTION BY SIMULTANEOUS IMMUNOHISTOCHEMICAL STAINING AND DNA HYBRIDIZATION." LABORATORY MEDICINE. Vol. 19, no. 4. (April 1988.): 240-242.

Waldman WJ, Sneddon JM, Stephens RE, Roberts WH. "ENHANCED ENDOTHELIAL CYTOPATHOGENICITY INDUCED BY A CYTOMEGALO-VIRUS STRAIN PROPAGATED IN ENDOTHELIAL-CELLS." Journal of Medical Virology. Vol. 28, no. 4. (August 1989.): 223-230.

Roberts WH, Sneddon JM, Waldman J, Stephens RE. "Cytomegalovirus infection of gastrointestinal endothelium demonstrated by simultaneous nucleic acid hybridization and immunohistochemistry.." Archives of Pathology & Laboratory Medicine. Vol. 113, no. 5. (January 1989.): 1-.

Sedmak DD, Roberts WH, Stephens RE, Buesching WJ, Morgan LA, Davis DH, Waldman WJ. "Inability of cytomegalovirus infection of cultured endothelial cells to induce HLA class II antigen expression.." Transplantation. Vol. 49, no. 2. (January 1990.): 1-.

Waldman WJ, Roberts WH, Davis DH, Williams MV, Sedmak DD, Stephens RE. "PRESERVATION OF NATURAL ENDOTHELIAL CYTOPATHOGENICITY OF CYTOMEGALOVIRUS BY PROPAGATION IN ENDOTHELIAL-CELLS." Archives of Virology. Vol. 117, no. 3-4. (January 1991.): 143-164.

Adams PW, Lee HS, Waldman WJ, Sedmak DD, Morgan CJ, Ward JS, Orosz CG. "ALLOANTIGENICITY OF HUMAN ENDOTHELIAL-CELLS .1. FREQUENCY AND PHENOTYPE OF HUMAN T-HELPER LYMPHOCYTES THAT CAN REACT TO ALLOGENEIC ENDOTHELIAL-CELLS." JOURNAL OF IMMUNOLOGY. Vol. 148, no. 12. (June 1992.): 3753-3760.

Waldman WJ, Adams PW, Orosz CG, Sedmak DD. "LYMPHOCYTE-T ACTIVATION BY CYTOMEGALOVIRUS-INFECTED, ALLOGENEIC CULTURED HUMAN ENDOTHELIAL-CELLS." Transplantation. Vol. 54, no. 5. (November 1992.): 887-896.

Waldman WJ, Knight DA, Adams PW, Orosz CG, Sedmak DD. "IN-VITRO INDUCTION OF ENDOTHELIAL HLA CLASS-II ANTIGEN EXPRESSION BY CYTOMEGALOVIRUS-ACTIVATED CD4(+) T-CELLS." Transplantation. Vol. 56, no. 6. (December 1993.): 1504-1512.

Waldman WJ, Knight DA, VanBuskirk A, Adams PW, Orosz CG, Sedmak DD. "Endothelial HLA class II induction mediated by allogeneic T cells activated by cytomegalovirus-infected cultured endothelial cells.." Transplantation Proceedings. Vol. 25, no. 1 Pt 2. (January 1993.): 1-.

Adams PW, Lee HS, Waldman WJ, Sedmak DD, Orosz CG. "ALLOANTIGENICITY OF HUMAN ENDOTHELIAL-CELLS .3. QUANTITATED INDIRECT PRESENTATION OF ENDOTHELIAL ALLOANTIGENS TO HUMAN HELPER T-LYMPHOCYTES." Transplantation. Vol. 58, no. 4. (August 1994.): 476-483.

Sedmak DD, Knight DA, Vook NC, Waldman WJ. "DIVERGENT PATTERNS OF ELAM-1, ICAM-1, AND VCAM-1 EXPRESSION ON CYTOMEGALOVIRUS-INFECTED ENDOTHELIAL-CELLS." Transplantation. Vol. 58, no. 12. (December 1994.): 1379-1385.

Sedmak DD, Guglielmo AM, Knight DA, Birmingham DJ, Huang EH, Waldman WJ. "CYTOMEGALOVIRUS INHIBITS MAJOR HISTOCOMPATIBILITY CLASS-II EXPRESSION ON INFECTED ENDOTHELIAL-CELLS." AMERICAN JOURNAL OF PATHOLOGY. Vol. 144, no. 4. (April 1994.): 683-692.

Waldman WJ, Knight DA, Huang EH, Sedmak DD. "Bidirectional transmission of infectious cytomegalovirus between monocytes and vascular endothelial cells: an in vitro model.." JOURNAL OF INFECTIOUS DISEASES. Vol. 171, no. 2. (February 1995.): 263-272.

Garrett JS, Narus JC, Bohnsack JF, Carling DE, Grieves KG, Waldman WJ, Shaddy RE. "EFFECTS OF CYTOMEGALOVIRUS-INFECTION ON GROWTH-FACTOR PRODUCTION IN ENDOTHELIAL-CELLS AND FIBROBLASTS." Pediatric Research. Vol. 38, no. 6. (December 1995.): 1003-1008.

Waldman WJ, Knight DA, Adams PW, Orosz CG, Sedmak DD. "In vitro induction of endothelial adhesion molecule and MHC antigen expression by cytomegalovirus-activated CD4+ T cells.." Transplantation Proceedings. Vol. 27, no. 1. (January 1995.): 1-.

Sedmak DD, Chaiwiriyakul S, Knight DA, Waldman WJ. "The role of interferon beta in human cytomegalovirus-mediated inhibition of HLA DR induction on endothelial cells.." Archives of Virology. Vol. 140, no. 1. (January 1995.): 1-.

Waldman WJ, Knight DA. "Cytokine-mediated induction of endothelial adhesion molecule and histocompatibility leukocyte antigen expression by cytomegalovirus-activated T cells." AMERICAN JOURNAL OF PATHOLOGY. Vol. 148, no. 1. (January 1996.): 105-119.

Waldman WJ, Adams PW, Knight DA, Sedmak DD. "CMV as an exacerbating agent in transplant vascular sclerosis: potential immune-mediated mechanisms modelled in vitro.." Transplantation Proceedings. Vol. 29, no. 1-2. (January 1997.): 1-.

Knight DA, Waldman WJ, Sedmak DD. "Human cytomegalovirus does not induce human leukocyte antigen class II expression on arterial endothelial cells." Transplantation. Vol. 63, no. 9. (May 1997.): 1366-1369.

Hanna AN, Waldman WJ, Lott JA, Koesters SC, Hughes AM, Thornton DJ. "Increased alkaline phosphatase isoforms in autoimmune diseases." Clinical Chemistry. Vol. 43, no. 8. (August 1997.): 1357-1364.

Waldman WJ, Knight DA, Huang EH. "An in vitro model of T cell activation by autologous cytomegalovirus (CMV)-infected human adult endothelial cells: Contribution of CMV-Enhanced endothelial ICAM-1." JOURNAL OF IMMUNOLOGY. Vol. 160, no. 7. (April 1998.): 3143-3151.

Waldman WJ, Knight DA, Adams PW. "Cytolytic activity against allogeneic human endothelia: resistance of cytomegalovirus-infected cells and virally activated lysis of uninfected cells.." Transplantation. Vol. 66, no. 1. (January 1998.): 1-.

Miller DM, Rahill BM, Boss JM, Lairmore MD, Durbin JE, Waldman WJ, Sedmak DD. "Human cytomegalovirus inhibits major histocompatibility complex class II expression by disruption of the Jak/Stat pathway." JOURNAL OF EXPERIMENTAL MEDICINE. Vol. 187, no. 5. (March 1998.): 675-683.

Waldman WJ, Knight DA, Lurain NS, Miller DM, Sedmak DD, Williams JW, Chong AS. "Novel mechanism of inhibition of cytomegalovirus by the experimental immunosuppressive agent leflunomide.." Transplantation. Vol. 68, no. 6. (January 1999.): 1-.

Waldman WJ, Knight DA, Blinder L, Shen J, Lurain NS, Miller DM, Sedmak DD, Williams JW, Chong AS. "Inhibition of cytomegalovirus in vitro and in vivo by the experimental immunosuppressive agent leflunomide.." Intervirology. Vol. 42, no. 5-6. (January 1999.): 1-.

Miller DM, Zhang YX, Rahill BM, Waldman WJ, Sedmak DD. "Human cytomegalovirus inhibits IFN-alpha-stimulated antiviral and immunoregulatory responses by blocking multiple levels of IFN-alpha signal transduction." JOURNAL OF IMMUNOLOGY. Vol. 162, no. 10. (May 1999.): 6107-6113.

Carrodeguas L, Orosz CG, Waldman WJ, Sedmak DD, Adams PW, VanBuskirk AM. "Trans vivo analysis of human delayed-type hypersensitivity reactivity." Human Immunology. Vol. 60, no. 8. (August 1999.): 640-651.

Knight DA, Waldman WJ, Sedmak DD. "Cytomegalovirus-mediated modulation of adhesion molecule expression by human arterial and microvascular endothelial cells." Transplantation. Vol. 68, no. 11. (December 1999.): 1814-1818.

Knight DA, Briggs BR, Bennett CF, Harindranath N, Waldman WJ, Sedmak DD. "Attenuation of cytomegalovirus-induced endothelial intercellular adhesion molecule-1 mRNA/protein expression and T lymphocyte adhesion by a 2'-O-methoxyethyl antisense oligonucleotide.." Transplantation. Vol. 69, no. 3. (January 2000.): 1-.

Knight DA, Hejmanowski AQ, Dierksheide JE, Williams JW, Chong ASF, Waldman WJ. "Inhibition of herpes simplex virus type 1 by the experimental immunosuppressive agent leflunomide." Transplantation. Vol. 71, no. 1. (January 2001.): 170-174.

Waldman WJ, Bickerstaff A, Gordillo G, Orosz K, Knight DA, Orosz CG. "Inhibition of angiogenesis-related endothelial activity by the experimental immunosuppressive agent leflunomide." Transplantation. Vol. 72, no. 9. (November 2001.): 1578-1582.

Waldman WJ, LeClaire JD, Knight DA. "T-cell activation response to allogeneic CMV-infected endothelial cells is not prevented by ganciclovir or foscarnet: implications for transplant vascular sclerosis.." Transplantation. Vol. 73, no. 2. (January 2002.): 1-.

Magro CM, Deng A, Pope-Harman A, Waldman WJ, Collins AB, Adams PW, Kelsey M, Ross P. "Humorally mediated posttransplantation septal capillary injury syndrome as a common form of pulmonary allograft rejection: A hypothesis." Transplantation. Vol. 74, no. 9. (November 2002.): 1273-1280.

Fach E, Waldman WJ, Williams M, Long J, Meister RK, Dutta PK. "Analysis of the biological and chemical reactivity of zeolite-based aluminosilicate fibers and particulates." Environmental Health Perspectives. Vol. 110, no. 11. (November 2002.): 1087-1096.

Eubank TD, Galloway M, Montague CM, Waldman WJ, Marsh CB. "M-CSF induces vascular endothelial growth factor production and angiogenic activity from human monocytes." JOURNAL OF IMMUNOLOGY. Vol. 171, no. 5. (September 2003.): 2637-2643.

Wusirika R, Ferri C, Marin M, Knight DA, Waldman WJ, Ross P, Magro CM. "The assessment of anti-endothelial cell antibodies in scleroderma-associated pulmonary fibrosis - A study of indirect immunofluorescent and Western blot analysis in 49 patients with scleroderma." American Journal of Clinical Pathology. Vol. 120, no. 4. (October 2003.): 596-606.

Fach E, Kristovich R, Long JF, Waldman WJ, Dutta PK, Williams MV. "The effect of iron on the biological activities of erionite and mordenite." Environment International. Vol. 29, no. 4. (July 2003.): 451-458.

Magro CM, Klinger DM, Adams PW, Orosz CG, Pope-Harman AL, Waldman WJ, Knight D, Ross P. "Evidence that humoral allograft rejection in lung transplant patients is not histocompatibility antigen-related." AMERICAN JOURNAL OF TRANSPLANTATION. Vol. 3, no. 10. (October 2003.): 1264-1272.

Magro CM, Ross P, Kelsey M, Waldman WJ, Pope-Harman A. "Association of humoral immunity and bronchiolitis obliterans syndrome." AMERICAN JOURNAL OF TRANSPLANTATION. Vol. 3, no. 9. (September 2003.): 1155-1166.

Magro CM, Allen J, Pope-Harman A, Waldman WJ, Moh P, Rothrauff S, Ross P. "The role of microvascular injury in the evolution of idiopathic pulmonary fibrosis." American Journal of Clinical Pathology. Vol. 119, no. 4. (April 2003.): 556-567.

Kristovich R, Knight DA, Long JF, Williams MV, Dutta PK, Waldman WJ. "Macrophage-mediated endothelial inflammatory responses to airborne particulates: Impact of particulate physicochemical properties." Chemical Research in Toxicology. Vol. 17, no. 10. (October 2004.): 1303-1312.

Shen YH, Utama B, Wang J, Raveendran M, Senthil D, Waldman WJ, Belcher JD, Vercellotti G, Martin D, Mitchelle BM, Wang XL. "Human cytomegalovirus causes endothelial injury through the ataxia telangiectasia mutant and p53 DNA damage signaling pathways." Circulation Research. Vol. 94, no. 10. (May 2004.): 1310-1317.

Avery RK, Bolwell BJ, Yen-Lieberman B, Lurain N, Waldman WJ, Longworth DL, Taege AJ, Mossad SB, Kohn D, Long JR, Curtis J, Kalaycio M, Pohlman B, Williams JW. "Use of leflunomide in an allogeneic bone marrow transplant recipient with refractory cytomegalovirus infection." Bone Marrow Transplantation. Vol. 34, no. 12. (December 2004.): 1071-1075.

Long JF, Waldman WJ, Kristovich R, Williams M, Knight D, Dutta PK. "Comparison of ultrastructural cytotoxic effects of carbon and carbon/iron particulates on human monocyte-derived macrophages." Environmental Health Perspectives. Vol. 113, no. 2. (February 2005.): 170-174.

Zeng HS, Waldman WJ, Yin DP, Knight DA, Shen JK, Ma LL, Meister GT, Chong AS, Williams J. "Mechanistic study of malononitrileamide FK778 in cardiac transplantation and CMV infection in rats." Transplantation. Vol. 79, no. 1. (January 2005.): 17-22.

Haynes LD, Waldman WJ, Bushkin Y, Love RB, Burlingham WJ. "CMV-infected allogeneic endothelial cells initiate responder and bystander donor HLA class I release via the metalloproteinase cleavage pathway." Human Immunology. Vol. 66, no. 3. (March 2005.): 211-221.

Chong AS, Zeng H, Knight DA, Shen J, Meister GT, Williams JW, Waldman WJ. "Concurrent antiviral and immunosuppressive activities of leflunomide in vivo.." American Journal of Transplantation. Vol. 6, no. 1. (January 2006.): 1-.

Magro CM, Waldman WJ, Knight DA, Allen JN, Nadasdy T, Frambach GE, Ross P, Marsh CB. "Idiopathic pulmonary fibrosis related to endothelial injury and antiendothelial cell antibodies." Human Immunology. Vol. 67, no. 4-5. (April 2006.): 284-297.

Williams CR, Sykes JE, Mehl M, MacLeod JS, Lindsay LL, Poland AM, Chen YJ, Kyles AE, Waldman WJ, Gregory CR. "In vitro effects of the active metabolite of leflunomide, A77 1726, on feline herpesvirus-1." American Journal of Veterinary Research. Vol. 68, no. 9. (September 2007.): 1010-1015.

Waldman WJ, Kristovich R, Knight DA, Dutta PK. "Inflammatory properties of iron-containing carbon nanoparticles." Chemical Research in Toxicology. Vol. 20, no. 8. (August 2007.): 1149-1154.

Magro CM, Marsh CB, Allen JN, Ross P, Liff D, Knight DA, Waldman WJ, Nadasdy T, Cowden DJ. "The role of anti-endothelial cell antibody-mediated microvascular injury in the evolution of pulmonary fibrosis in the setting of collagen vascular disease." American Journal of Clinical Pathology. Vol. 127, no. 2. (February 2007.): 237-247.

Zhang G, Raghavan B, Kotur M, Cheatham J, Sedmak D, Cook C, Waldman J, Trgovcich J. "Antisense transcription in the human cytomegalovirus transcriptome.." Journal of Virology. Vol. 81, no. 20. (January 2007.): 1-.

Magro CM, Schaefer JT, Waldman J, Knight D, Seilstad K, Hearne D. "Terbinafine-induced dermatomyositis: a case report and literature review of drug-induced dermatomyositis.." Journal Of Cutaneous Pathology. Vol. 35, no. 1. (January 2008.): 74-.

Machesky NJ, Zhang G, Raghavan B, Zimmerman P, Kelly SL, Merrill AH Jr, Waldman WJ, Van Brocklyn JR, Trgovcich J. "Human cytomegalovirus regulates bioactive sphingolipids." JOURNAL OF BIOLOGICAL CHEMISTRY. Vol. 283, no. 38. (September 2008.): 26148-26160.

Ruda-Eberenz TA, Nagy A, Waldman WJ, Dutta PK. "Entrapment of ionic tris(2,2 '-bipyridyl) ruthenium(II) in hydrophobic siliceous zeolite: O-2 sensing in biological environments." LANGMUIR. Vol. 24, no. 16. (August 2008.): 9140-9147.

Waldman WJ, Williams MV, Lemeshow S, Binkley P, Guttridge D, Kiecolt-Glaser JK, Knight DA, Ladner KJ, Glaser R. "Epstein-Barr virus-encoded dUTPase enhances proinflammatory cytokine production by macrophages in contact with endothelial cells: Evidence for depression-induced atherosclerotic risk." BRAIN BEHAVIOR AND IMMUNITY. Vol. 22, no. 2. (February 2008.): 215-223.

Schumacher W, Nagy A, Waldman WJ, Dutta PK. "Direct Synthesis of Aqueous CdSe/ZnS-Based Quantum Dots Using Microwave Irradiation." JOURNAL OF PHYSICAL CHEMISTRY C. Vol. 113, no. 28. (July 2009.): 12132-12139.

Dunn M, Knight D, Waldman WJ. "Antiviral Activity of Leflunomide Against Respiratory Syncytial Virus." ANTIVIRAL RESEARCH. Vol. 86, no. 1. (April 2010.): A26-A26.

Sabbani S, Gallego-Perez D, Nagy A, Waldman WJ, Hansford D, Dutta PK. "Synthesis of silver-zeolite films on micropatterned porous alumina and its application as an antimicrobial substrate." MICROPOROUS AND MESOPOROUS MATERIALS. Vol. 135, no. 1-3. (November 2010.): 131-136.

Avery RK, Mossad SB, Poggio E, Lard M, Budev M, Bolwell B, Waldman WJ, Braun W, Mawhorter SD, Fatica R, Krishnamurthi V, Young JB, Shrestha R, Stephany B, Lurain N, Yen-Lieberman B. "Utility of Leflunomide in the Treatment of Complex Cytomegalovirus Syndromes." TRANSPLANTATION. Vol. 90, no. 4. (August 2010.): 419-426.

Peebles B, Nagy A, Waldman WJ, Dutta PK. "Fenton Activity and Cytotoxicity Studies of Iron-Loaded Carbon Particles." ENVIRONMENTAL SCIENCE & TECHNOLOGY. Vol. 44, no. 17. (September 2010.): 6887-6892.

Peebles BC, Dutta PK, Waldman WJ, Villamena FA, Nash K, Severance M, Nagy A. "Physicochemical and Toxicological Properties of Commercial Carbon Blacks Modified by Reaction with Ozone." ENVIRONMENTAL SCIENCE & TECHNOLOGY. Vol. 45, no. 24. (December 2011.): 10668-10675.

Nagy A, Zane A, Cole SL, Severance M, Dutta PK, Waldman WJ. "Contrast of the Biological Activity of Negatively and Positively Charged Microwave Synthesized CdSe/ZnS Quantum Dots." CHEMICAL RESEARCH IN TOXICOLOGY. Vol. 24, no. 12. (December 2011.): 2176-2188.

Dunn MCC, Knight DA, Waldman WJ. "Inhibition of respiratory syncytial virus in vitro and in vivo by the immunosuppressive agent leflunomide." ANTIVIRAL THERAPY. Vol. 16, no. 3. (January 2011.): 309-317.

Nagy A, Harrison A, Sabbani S, Munson RS, Dutta PK, Waldman WJ. "Silver nanoparticles embedded in zeolite membranes: release of silver ions and mechanism of antibacterial action." INTERNATIONAL JOURNAL OF NANOMEDICINE. Vol. 6, (January 2011.): 1833-1852.

Binkley PF, Cooke GE, Lesinski A, Taylor M, Chen M, Laskowski B, Waldman WJ, Ariza ME, Williams MV, Knight DA, Glaser R. "Evidence for the Role of Epstein Barr Virus Infections in the Pathogenesis of Acute Coronary Events." PLOS ONE. Vol. 8, no. 1. (January 2013.): e54008-.