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Werner Tjarks, PhD


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500 W 12th Ave
Columbus, OH 43210

Phone: (614) 292-7624

Email: tjarks.1@osu.edu

 

Current OSU Appointment

Professor, Pharm CBO/Coll

 

Academic Advising

2007 , The Ohio State University College of Pharmacy.
2007 , The Ohio State University College of Pharmacy.
2006 - 2009 , The Ohio State University College of Pharmacy.
 

Chapters in Books

Nano Vehicles and High Molecular Weight Delivery Agents for Boron Neutron Capture Therapy

Neutron capture therapy of cancer: Nanoparticles and high molecular weight boron delivery agents

Boron cluster (radio)halogenation in biomedical research

 

Conferences

The Preparation and Biodistribution of Boronated Thioureas for Neutron Capture Therapy

Investigations of Boron Conjugated Thiouracil Derivatives for Neutron Capture Therapy of Melanoma

Pharmacokinetics of Boron Containing Thiouracil Derivatives in the Murine and Human-Melanoma Nude-Mouse Model

Cellular Uptake and Distribution of 2’-O-(o-Carboran-1-ylmethyl)uridine (CBU). A Potential Delivery Agent for Boron Neutron Capture Therapy (BNCT)

APPROACHES TO THE DESIGN AND EVALUATION OF COMPOUNDS FOR BNCT

CARBORANYL PRECURSORS OF NUCLEIC-ACIDS - POTENTIAL DNA PROBES FOR BNCT

Direct Intratumorall Injection of 2’-O-(o-Carboran-1-ylmethyl)uridine (CBU-2’). A Potential Delivery Agent for Boron Neutron Capture Therapy (BNCT)

Cellular and Biochemical Studies on 2’-O-(o-Carboran-1-ylmethyl)uridine (CBU-2’). A Delivery Agent for Boron Neutron Capture Therapy (BNCT)

SYNTHESIS AND BIOLOGICAL PROPERTIES OF BORONATED THIOUREAS AS HIGHLY SELECTIVE TUMOR SEEKERS FOR MELANOMA

CELLULAR UPTAKE, SUBCELLULAR-DISTRIBUTION AND IN-VITRO TOXICITY OF CARBORANYL URIDINES

SYNTHESIS OF CARBORANE-CONTAINING NUCLEOSIDES, NUCLEOTIDES, AND CARBOHYDRATES FOR BNCT

DESIGN OF BORON COMPOUNDS FOR NEUTRON CAPTURE THERAPY

The rationale for the development of boron-containing nucleosides for boron-neutron capture therapy

New small molecular weight agents for boron neutron capture therapy

Synthesis and initial biological evaluation of carborane-containing phenanthridinium derivatives

Boron neutron capture therapy against tumor cells with overexpression of the EGF-receptor

Carboranyl phenanthridinium analogues: Synthesis and biological evaluation

Synthesis of water-soluble p-carboranyl derivatives of phenanthridine and acridine for BNCT

Melanoma and nonmelanoma neutron capture therapy using gene therapy: overview

Synthesis of water-soluble p-carboranyl derivatives of phenanthridine and acridine for BNCT

Two-step targeting: EGF-conjugate for delivery of DNA-binding boron compounds

Boranes in developing of tumor-targeting agents for Boron Neutron Capture Therapy.

Synthesis and evaluation of DNA tumor targeting agents for neutron capture therapy

Carboranyl nucleosides for BNCT.

Synthesis and Evaluation of Boronated Folates for BNCT

Boronated Nucleosides for BNCT

Enhanced Survival of Glioma Bearing Rats Using a Combination of Boronated Epidermal Groth Factor and Boronophenylalanine

Synthesis and evaluation of DNA tumor targeting agents for neutron capture therapy

Potential BNCT agents - Synthesis of boron-containing pyrimidine nucleoside and approaches in the synthesis of.4-borauracil

Synthesis and biological evaluation of boronated folates for BNCT.

Strategies to improve the efficacy of neutron capture therapy of brain tumors by optimizing delivery of boron compounds

Synthesis and biological evaluation of carboranyl thymidines for BNCT.

Tumor cell-selective delivery of boron compound via folate receptor targeted liposomes

Evaluation of carboranyl 2'-deoxyuridine derivatives as substrates for human thymidine kinases 1 and 2

The biological evaluation of a small library of 3-(carboranylalkyl) thymidines as substrates for human thymidine kinases 1 and 2

Molecular targeting of EGFRvIII positive gliomas: Convection enhanced delivery vs. intratumoral injection of boronated monoclonal antibody L8A4

Molecular targeting of Gliomas Using Monoclonal Antibody (MoAb) L8A4 Directed Against Epidermal Growth Factor Receptor vIII (EGFRvIII)

Synthesis and biological evaluation of hydrophylically enhanced N-3 carboranyl thymidine analogues for BNCT.

Conjugation of boron containing dendrimers to anti-EGF receptor monoclonal antibody cetuximab and its evaluation as a delivery agent for neutron capture therapy

Neutron capture therapy of brain tumors: Molecular targeting of the epidermal growth factor receptor with boronated bioconjugates

Hydrophylic 3-carboranyl thymidine analogues (3CTAs) for boron neutron capture therapy (BNCT)

Liposomal formulations of carboranyl cholesterol derivatives for boron neutron capture therapy (BNCT)

Structural and functional aspects of zwitterionic nido-7-NH3-7,9-C2B9H12

Novel boron containing gadolinium texaphyrins

Three-dimensional QSAR studies on human thymidine kinase-1 substrates.

Neutron Capture Therapy of an EGF Receptor Positive Glioma Using Boronated Cetuximab Alone or in Combination with Boronophenylalanine

In vivo Evaluation of the 3-Carboranyl Thymidine Analogue (3-CTA), N5-2OH, for Neutron Capture Therapy

Thymidine kinase 1 as a molecular target for neutron capture therapy of brain tumors

Molecular targeting and treatment of composite EGFRvIII and EGFR-positive gliomas using boronated monoclonal antibodies

Boronated epidermal growth factor as a molecular targeting agent for neutron capture therapy of EGFR positive gliomas

Cage-iodination of o-carboranyl nucleoside analogs for the diagnosis and treatment of cancer

Carboranyl Uridines as BNCT Agents

 

Journal Articles

"SYNTHESIS AND INVITRO EVALUATION OF BORONATED URIDINE AND GLUCOSE DERIVATIVES FOR BORON NEUTRON-CAPTURE THERAPY." JOURNAL OF MEDICINAL CHEMISTRY. Vol. 35, no. 9. (May 1992.): -.

"Synthesis and biological evaluation of boron-containing polyamines as potential agents for neutron capture therapy of brain tumors." JOURNAL OF MEDICINAL CHEMISTRY. Vol. 42, no. 7. (April 1999.): -.

"Comparative in vitro evaluation of dequalinium B, a new boron carrier for neutron capture therapy (NCT)." ANTICANCER RESEARCH. Vol. 20, no. 5B. (September 2000.): -.

"In vivo evaluation of phosphorous-containing derivatives of dodecahydro-closo-dodecaborate for boron neutron capture therapy of gliomas and sarcomas." ANTICANCER RESEARCH. Vol. 21, no. 2A. (March 2001.): -.

"Convection-enhanced delivery of boronated epidermal growth factor for molecular targeting of EGF receptor-positive gliomas." CANCER RESEARCH. Vol. 62, no. 22. (November 2002.): -.

"Molecular targeting of the epidermal growth factor receptor for neutron capture therapy of gliomas." CANCER RESEARCH. Vol. 62, no. 11. (June 2002.): -.

"Boron-containing folate receptor-targeted liposomes as potential delivery agents for neutron capture therapy." BIOCONJUGATE CHEMISTRY. Vol. 13, no. 3. (May 2002.): -.

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Reference Works

December 1988 Patwardhan, A.; Tamat, R.; Moore, D. E.; Wilson, J. G.; Allen, B. J.; Mishima, Y.; Ishihashi, M.; Kahl, S. B.; Tjarks, W.; Gabel, D."Pharmacokinetic Studies of Boronated Conjugated Biochemicals in Nude Mice" .
December 1988 Brown, J. K.; Mountford, M. H.; Allen, B. J.; Wilson, J. G.; Kahl, S. B.; Tjarks,W.; Gabel, D."In Vitro Incorporation of Boron Tetraphenyl Porphyrin, Carboranyl and Dihydroxyboryl Thiouracil in B16 MelanomaCells" .
December 1988 Barkla, D. H.; Allen, B. J.; Wilson, J. G.; Patwardhan, A.; Tjarks, W.; Gabel, D."The Biodistribution of Two Boronated Thiouracil Compounds in Human and Murine Melanoma Xenografts" .
May 1988 Tjarks, W.; Gabel, D.;."Synthesis of Boronated Thioureas for Neutron Capture Therapy" .
January 1990 Corderoy-Buck, S.; Wilson, J.G.; Gabel, D.; Tjarks, W.; Moore, D.E.; Chandler, A."Pharmacokinetics of Boron Containing Thiouracil Derivtives in the Murine and Human-Melanoma Nude-Mouse Mode" .
January 1990 Gabel, D.; Tjarks, W.; Ketz, H."The Preparation and Biodistribution of Boronated Thioureas for Neutron Capture Therapy" .
January 1991 Liu, L.; Barth, R.F.; Soloway, A.H.; Anisuzzaman, A.K.M.; Alam, F.; Tjarks,W.; Zha, X-.H.; Morrison, G.H."Cellular Uptake and Distribution of 2’-O-(o-Carboran-1-ylmethyl)uridine (CBU). A Potential Delivery Agentfor Boron Neutron Capture Therapy (BNCT)" .
June 1991 Tjarks, W.; Gabel, D.; Anisuzzaman, A.K.M.; Soloway, A.H.; Liu, L.; Barth,R.F.."Boron-Containing Tumor Localizer for Boron Neutron Capture Therapy of Cancer" .
July 1992 11. Tjarks, W.; Anisuzzaman, A.K.M.; Soloway, A.H."Synthesis of Carborane-Containing Nucleosides from Ribofuranosylcarboranes" .
January 1992 Nishihara, K.; Barth, R.F.; Liu, L.; Tjarks, W.; Soloway, A.H.; Staubus, A.E.; Rotaru, J.; Adams, D.M.; Bendayan, M.; Kassis, A."Direct Intratumorall Injection of 2’-O-(o-Carboran-1-ylmethyl)uridine (CBU-2’)" .
July 1993 12. Lunato, A.J.; Tjarks, W.; Anisuzzaman, A.K.M.; Soloway, A.H."5-S-Alkyl Carboranyl Uridines as BNCT Agents" .

Inventions and Patents

Carboranyl uridines and their use in boron neutron capture therapy

2' and 3' Carboranyl uridines and their diethyl ether adducts

 

Presentations

Synthesis of Boronated Thioureas for Neutron Capture Therapy; Third International Symposium on Neutron Capture Therapy, Bremen

The Biodistribution of Two Boronated Thiouracil Compounds in Human and Murine Melanoma Xenografts

In Vitro Incorporation of Boron Tetraphenyl Porphyrin, Carboranyl and Dihydroxyboryl Thiouracil in B16 Melanoma Cells

Pharmacokinetic Studies of Boronated Conjugated Biochemicals in Nude Mice

Boron-Containing Tumor Localizer for Boron Neutron Capture Therapy of Cancer

Synthesis of Carborane-Containing Nucleosides from Ribofuranosylcarboranes

The Synthesis of 5-S-Alkyl Carboranyl Uridines as Boron Carriers for Boron Neutron Capture Therapy of Cancer

Development of Boron Delivery Systems for Neutron Capture Therapy of Cancer

5-S-Alkyl Carboranyl Uridines as BNCT Agents

Synthesis of Low Molecular Weight Boron Compounds for Boron Neutron Capture Therapy (BNCT) of Cancer

Synthesis of Boronated DNA Intercalator for Potential Use in BNCT

Boron-Containing Phenanthridines for BNCT

The Development of Boron-Containing Chemical Modifiers as Potential Agents for Neutron Capture Therapy

Synthesis and Biological Evaluation of New Boron-Containing Polyamines for BNCT

Synthesis, Characterization and Animal Testings of New Boronated Phosphonate and gem-Bisphosphonate

Biological Evaluation of Carboranyl Nucleosides for BNCT

Synthesis and Evaluation of Boron-Containing Pyrimidines and Pyrimidine Nucleosides for Boron Neutron Capture Therapy of Cancer

Synthesis and Evaluation of Boron-Containing Pyrimidines and Pyrimidine Nucleosides for Boron Neutron Capture Therapy of Cancer

Boronated Nucleosides for BNCT

Synthesis and Evaluation of Boron-Containing Pyrimidines and Pyrimidine Nucleosides for Boron Neutron Capture Therapy of Cancer

Synthesis and Evaluation of Boron-Containing Pyrimidines and Pyrimidine Nucleosides for Boron Neutron Capture Therapy of Cancer

Synthesis and Evaluation of Boron-Containing Pyrimidines and Pyrimidine Nucleosides for Boron Neutron Capture Therapy of Cancer

Recent Progress in BNCT Compound Development

Synthesis and Evaluation of Boronated Folates for BNCT

Biological Evaluation of Boronated Nucleosides for Boron Neutron Capture Therapy (BNCT) of Cancer

Boron neutron capture therapy of brain tumors: Enhanced survival of glioma bearing rats following intratumoral injection of boronated epidermal growth factor

Synthesis and Biological Evaluation of Polyethylene Glycol Modified Carboranyl Nucleosides for Boron Neutron Capture Therapy

Synthesis of A Novel Series of 3-Carboranyl Ethylene Oxide Derivatives of Thymidine And Their Evaluation as Substrates for Human Thymidine Kinase 1

Development and Biological Evaluation of New Agents for Neutron Capture Therapy

Design of a Homology model of Deoxycyidine Kinase and Docking Simulation of some Substrates

A Novel and Convenient Strategy for Molecular Modeling of Carborane Containing Compounds

Biochemical and Biological Evaluation of 3-(Carboranylalkyl) Thymidines as Substrates for Human Thymidine Kinase

Synthesis and biochemical evaluation of zwitterionic carboranyl thymidine analogues

Molecular targeting of epidermal growth factor receptor (EGFR) positive gliomas for neutron capture therapy using boronated bioconjugates

Structure-activity Relationship of Thymidine Kinase 1 as the basis for developing new candidates for boron neutron capture therapy

Texaphyrins for the diagnosis and therapy of brain tumors

Boronated nucleosides for neutron capture therapy of brain cancer

A Standardized Procedure For Derivatization of Nanoparticles With functionally active Proteins

Boron Delivery Systems for Neutron Capture Therapy of Cancer

A Novel Boronated Pyrrole

Blind Docking Strategies For the Identification of Novel Inhibitors of Thymidine Kinase

Boronated Nucleosides for Neutron Capture Therapy of Cancer

Compound Development in Neutron Capture Therapy: Texaphyrins Containing Boron and Gadolinium

Development of Novel Agents for Neutron Capture Therapy (NCT) of Cancer

Carboranyl Nucleosides for Neutron Capture Therapy

The development of synthetic organic methods for the preparation of texaphyrins containing boron and gadolinium as potential multi-purpose cancer therapeutics and diagnostics

Synthesis of N-3 substituted thymines

Targeting enzymes of the de novo and the salvage pathways of DNA synthesis in Bacillus anthracis

Structure and function studies of Bacillus anthracis Thymidine kinase and nucleoside analog as antibiotics

Synthesis of novel boron-and lanthanide-containing texaphyrins

ESF/EMRC Exploratory Workshop: BioBor – Exploring New Opportunities Of Boron Chemistry Towards Medicine

DNA precursor enzymes and borano nucleosides

Carboranyl Thymidine Analogues for Cancer Therapy and Diagnosis

The synthesis of texaphyrins as novel agents for fighting cancer

Selective monoiodination of carboranyl thymidine analogues for the diagnosis and treatment of cancer

Synthetic Studies on 3-Carboranyl Thymidine Analogues (3CTAs) for Boron Neutron Capture Therapy (BNCT)

Synthesis of N3-Substituted Amidine-, Guanidine-, and Tetrazol-Type m-Carboranyl thymidine analogues

Boronated Nucleosides for Neutron Capture Therapy of Cancer

Synthesis, stability and solubility studies of the amino acid prodrugs of 3-carboranyl thymidine analogues (3-CTAs) for boron neutron capture therapy (BNCT)

Synthesis of carboranyl conjugates of N3-substituted thymidine and their evaluation as substrates of recombinant human thymidine kinase 1

Iodine Monochloride Facilitated Deglycosylation, Anomerization, and Isomerisation of N3-Substituted Thymidine Analogues

A Newly Identified Aminothiazole with Antifungal Activity for Intracellular Histoplasma capsulatum.

Investigation of halogenated o- & m-carborane derivatives using NMR-spectroscopic and X-ray crystallographic technique