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Susheela Tridandapani, PhD


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473 W 12th Ave
Columbus, OH 43210

Phone: (614) 247-6768

Email: tridandapani.2@osu.edu

 

Current OSU Appointments

Professor, Hematology

Professor, SBS-Microbial Infectn/Immunity

 

Biographical

Dr. Susheela Tridandapani is a Professor of Internal Medicine in the Division of Pulmonary, Allergy, Critical Care and Sleep Medicine. She obtained her PhD in 1998, following which she pursued postdoctoral work at Harvard University and at the Ohio State University. She was appointed to the Faculty in Internal Medicine in 2002. Dr. Tridandapani has a fully funded (NIAID, NCI) research program examining the molecular mechanisms of innate immune responses to bacterial pathogens and IgG-immune complexes, particularly in the context of monoclonal antibody therapy for cancer. She has trained and continues to train numerous graduate students and postdoctoral fellows who have successfully competed for prestigious fellowships from NIH, AHA and ACS. She currently serves as the Co-Director of the Lung Inflammation T32 Program.

Academic Advising

2002 Rosemary Keogh The Ohio State University.
2003 Katie Hua The Ohio State University.
2004 Amita Maturu The Ohio State University.
2002 - 2005 Ruma Pengal The Ohio State University. Graduated 2005. Molecular mechanisms of regulation of the macrophage inflammatory response.
2003 - 2005 Ju Young The Ohio State University. Graduated 2005.
2004 - 2005 Wesley Johnson The Ohio State University.
2004 - 2006 Nicolas Kin The Ohio State University. Graduated 2006.
2004 - 2006 Jing Ai The Ohio State University. Graduated 2006. MOLECULAR STUDIES ON G-CSF RECEPTOR SIGNALING IN GRANULOCYTES & REGULATION OF FC? RECEPTOR FUNCTION IN MACROPHAGES
2002 - 2007 Latha Ganesan The Ohio State University. Graduated 2007.
2003 - 2007 Trupti Joshi The Ohio State University. Graduated 2007. MOLECULAR ANALYSIS OF THE ROLE OF Fc?RIIb, SHIP AND PI 3-KINASE IN MACROPHAGE Fc?RECEPTOR FUNCTION
2004 - 2007 Julie Roda The Ohio State University. Graduated 2007.
2004 - 2007 Payal Mehta The Ohio State University.
2005 - 2007 Ju Ping The Ohio State University. Graduated 2007.
2006 - 2007 Anne-Sophie Wavreille The Ohio State University. Graduated 2007.
2007 Jackie McAlees The Ohio State University.
2007 Nesrine Affara The Ohio State University.
2004 - 2008 Raquel Raices The Ohio State University. Graduated 2008.
2005 - 2008 Murugesan Rajaram The Ohio State University.
2005 - 2008 Sudarshan Seshadri The Ohio State University. Graduated 2008.
2005 - 2008 Kishore Parsa The Ohio State University. Graduated 2007. MOLECULAR MECHANISMS OF HOST CELL RESPONSE TO Francisella INFECTION
2006 - 2008 Lisa Henning The Ohio State University. Graduated 2008.
2008 Nicolas Vassel The Ohio State University. Graduated 2008.
2008 Amber Nagy The Ohio State University.
2005 - 2009 Jennifer Curry The Ohio State University.
2006 - 2009 Corey Clay The Ohio State University. Graduated 2009.
2006 - 2009 Amanda Beltramini The Ohio State University. Graduated 2009.
2006 - 2009 Jonathan Butchar The Ohio State University. Graduated 2008.
2006 - 2009 Tahera Zabuawalla The Ohio State University.
2007 - 2009 Krithika Selvarajan The Ohio State University.
2007 - 2009 Thomas Cremer The Ohio State University. Graduated 2009.
2008 - 2009 Krithika Selvarajan The Ohio State University. Graduated 2009.
2008 - 2010 David Ravneberg The Ohio State University. Graduated 2010.
2010 Kavin Fatechand The Ohio State University.
2007 - 2011 Duaa Dakhlallah The Ohio State University. Graduated 2011.
2008 - 2011 Yashaswini Kannan The Ohio State University.
2008 - 2011 Christopher Alvarez-Breckenridge The Ohio State University. Graduated 2011.
2008 - 2011 Steven Justiniano The Ohio State University.
2008 - 2013 Steven Vadia The Ohio State University.
2008 - 2013 Mary Forget The Ohio State University.
2010 - 2013 Devyn Gilette The Ohio State University. Graduated 2013.
 

Chapters in Books

Tridandapani S, CL Anderson. "Regulation of FcyR-Mediated Phagocytosis by FcyRIIb and Phosphatases." In Molecular Mechanisms of Phagocytosis. -. January 2005.

 

Degrees

1983 B.S., University of Madras

1998 Ph.D., The Ohio State University

 

Editorial Activities

2001 - 2008 Journal of Immunology
2002 - present Leukemia
2002 - present Journal of Leukocyte Biology
2002 - present Experimental Hematology
2002 - present Blood
2002 - present Atherosclerosis, Thrombosis and Vascular Biology
2002 - present American Journal of Pathology
2002 - 2006 Cancer Research
2009 - present PLoS ONE
2009 - present Journal of Immunology
2010 - present Frontiers in Microbiology
 

Honors

1996 ICSABER Award.
1996 N. Paul Hudson Award. Ohio Regional ASM Meeting.
2000 - 2003 Fellow Award. Leukemia and Lymphoma Society.
 

Journal Articles

CHACKO,G,W; Tridandapani,S; Damen,J,E; Liu,L; Krystal,G; Coggeshall,K,M. "Negative signaling in B lymphocytes induces tyrosine phosphorylation of the 145-kDa inositol polyphosphate 5-phosphatase, SHIP." JOURNAL OF IMMUNOLOGY. Vol. 157, no. 6. (September 1996.): 2234-2238.

Tridandapani,S; Kelley,T; Cooney,D; Pradhan,M; Coggeshall,K,M. "Negative signaling in B cells: SHIP Grbs Shc." IMMUNOLOGY TODAY. Vol. 18, no. 9. (September 1997.): 424-427.

Tridandapani,S; Kelley,T; Pradhan,M; Cooney,D; Justement,L,B; Coggeshall,K,M. "Recruitment and phosphorylation of SH2-containing inositol phosphatase and she to the B-cell Fc gamma immunoreceptor tyrosine-based inhibition motif peptide motif." MOLECULAR AND CELLULAR BIOLOGY. Vol. 17, no. 8. (August 1997.): 4305-4311.

Tridandapani,S; Phee,H; Shivakumar,L; Kelley,T,W; Coggeshall,K,M. "Role of SHIP in Fc gamma RIIb-mediated inhibition of Ras activation in B cells." MOLECULAR IMMUNOLOGY. Vol. 35, no. 17. (December 1998.): 1135-1146.

Tridandapani,S; Pradhan,M; LaDine,J,R; Garber,S; Anderson,C,L; Coggeshall,K,M. "Protein interactions of Src homology 2 (SH2) domain-containing inositol phosphatase (SHIP): Association with Shc displaces SHIP from Fc gamma RIIb in B cells." JOURNAL OF IMMUNOLOGY. Vol. 162, no. 3. (February 1999.): 1408-1414.

Jacob,A; Cooney,D; Tridandapani,S; Kelley,T; Coggeshall,K,M. "Fc gamma RIIb modulation of surface immunoglobulin-induced Akt activation in murine B cells." JOURNAL OF BIOLOGICAL CHEMISTRY. Vol. 274, no. 19. (May 1999.): 13704-13710.

Tridandapani S, Smith JL, Lyden TW, Coggeshall KM, CL Anderson. "Linker for activation of T cells (LAT) supports Fcy receptor-mediated signal transduction in myeloid cells." J. Biol. Chem. Vol. 275(27), (January 2000.): 20480-20487.

Lyden TW, Robinson JM, Tridandapani S, Teillaud J-L, Garber S, Osborn JM, Frey J, CL Anderson. "The IgG receptor expressed in placental endothelial cells is FcyRIIb2." J. Immunol.. Vol. 166, (January 2001.): 3882-3889.

Chi,M; Tridandapani,S; Zhong,W,J; Coggeshall,K,M; Mortensen,R,F. "C-reactive protein induces signaling through Fc gamma RIIa on HL-60 granulocytes." JOURNAL OF IMMUNOLOGY. Vol. 168, no. 3. (February 2002.): 1413-1418.

Albrecht,B; D'Souza,C,D; Wei,D; Tridandapani,S; Coggeshall,K,M; Lairmore,M,D. "Activation of nuclear factor of activated T cells by human T-Lymphotropic virus type 1 accessory protein p12(I)." JOURNAL OF VIROLOGY. Vol. 76, no. 7. (April 2002.): 3493-3501.

Tridandapani,S; Wang,Y,J; Marsh,C,B; Anderson,C,L. "Src homology 2 domain-containing inositol polyphosphate phosphatase regulates NF-kappa B-mediated gene transcription by phagocytic Fc gamma Rs in human myeloid cells." JOURNAL OF IMMUNOLOGY. Vol. 169, no. 8. (October 2002.): 4370-4378.

Tridandapani,S; Siefker,K; Teillaud,J,L; Carter,J,E; WEWERS,M,D; Anderson,C,L. "Regulated expression and inhibitory function of Fc gamma RIIb in human monocytic cells." JOURNAL OF BIOLOGICAL CHEMISTRY. Vol. 277, no. 7. (February 2002.): 5082-5089.

Pengal,R,A; Ganesan,L,P; Fang,H,Q; Marsh,C,B; Anderson,C,L; Tridandapani,S. "SHIP-2 inositol phosphatase is inducibly expressed in human monocytes and serves to regulate Fc gamma receptor-mediated signaling." JOURNAL OF BIOLOGICAL CHEMISTRY. Vol. 278, no. 25. (June 2003.): 22657-22663.

Ganesan,L,P; Fang,H,Q; Marsh,C,B; Tridandapani,S. "The protein-tyrosine phosphatase SHP-1 associates with the phosphorylated immunoreceptor tyrosine-based activation motif of Fc gamma RIIa to modulate signaling events in myeloid cells." JOURNAL OF BIOLOGICAL CHEMISTRY. Vol. 278, no. 37. (September 2003.): 35710-35717.

Baran,C,P; Tridandapani,S; Helgason,C,D; Humphries,R,K; Krystal,G; Marsh,C,B. "The inositol 5 '-phosphatase SHIP-1 and the Src kinase Lyn negatively regulate macrophage colony-stimulating factor-induced Akt activity." JOURNAL OF BIOLOGICAL CHEMISTRY. Vol. 278, no. 40. (October 2003.): 38628-38636.

Tridandapani,S; Wardrop,R; Baran,C,P; Wang,Y,J; Opalek,J,M; Caligiuri,M,A; Marsh,C,B. "TGF-beta 1 supresses myeloid Fc gamma receptor function by regulating the expression and function of the common gamma-subunit." JOURNAL OF IMMUNOLOGY. Vol. 170, no. 9. (May 2003.): 4572-4577.

Cao,X,H; Wei,G; Fang,H,Q; Guo,J,P; WEINSTEIN,M; Marsh,C,B; Ostrowski,M,C; Tridandapani,S. "The inositol 3-phosphatase PTEN negatively regulates Fc gamma receptor signaling, but supports Toll-Like receptor 4 signaling in murine peritoneal macrophages." JOURNAL OF IMMUNOLOGY. Vol. 172, no. 8. (April 2004.): 4851-4857.

Fang,H,Q; Pengal,R,A; Cao,X,H; Ganesan,L,P; WEWERS,M,D; Marsh,C,B; Tridandapani,S. "Lipopolysaccharide-induced macrophage inflammatory response is regulated by SHIP." JOURNAL OF IMMUNOLOGY. Vol. 173, no. 1. (July 2004.): 360-366.

Wang,Y,J; Keogh,R,J; Hunter,M,G; Mitchell,C,A; Frey,R,S; Javaid,K; Malik,A,B; Schurmans,S; Tridandapani,S; Marsh,C,B. "SHIP2 is recruited to the cell membrane upon macrophage colony-stimulating factor (M-CSF) stimulation and regulates M-CSF-induced signaling." JOURNAL OF IMMUNOLOGY. Vol. 173, no. 11. (December 2004.): 6820-6830.

Ganesan,L,P; Wei,G; Pengal,R,A; Moldovan,L; Moldovan,N; Ostrowski,M,C; Tridandapani,S. "The serine/threonine kinase Akt promotes Fc gamma receptor-mediated phagocytosis in murine macrophages through the activation of p70S6 kinase." JOURNAL OF BIOLOGICAL CHEMISTRY. Vol. 279, no. 52. (December 2004.): 54416-54425.

Baran,C,P; Zeigler,M,M; Tridandapani,S; Marsh,C,B. "The role of ROS and RNS in regulating life and death of blood monocytes." CURRENT PHARMACEUTICAL DESIGN. Vol. 10, no. 8. (January 2004.): 855-866.

Parihar R, Trotta R, Roda JM, Ferketich AK, Tridandapani S, Caligiuri MA, WE Carson. "SHIP1 negatively regulates cytokine production by NK cells stimulated with antibody-coated tumor cells and IL-12." Cancer Research. Vol. 65, (January 2005.): 9099-9107.

Trotta,R; Parihar,R; Yu,J,H; Becknell,B; Allard,J; Wen,J; Ding,W; Mao,H; Tridandapani,S; Carson,W,E; Caligiuri,M,A. "Differential expression of SHIP1 in CD56(bright) and CD56(dim) NK cells provides a molecular basis for distinct functional responses to monokine costimulation." BLOOD. Vol. 105, no. 8. (April 2005.): 3011-3018.

Sweeney,M,C; Wavreille,A,S; Park,J; Butchar,J,P; Tridandapani,S; Pei,D. "Decoding protein-protein interactions through combinatorial chemistry: Sequence specificity of SHP-1, SHP-2, and SHIPSH2 domains." BIOCHEMISTRY. Vol. 44, no. 45. (November 2005.): 14932-14947.

Roda,J,M; Parihar,R; MAGRO,C; Nuovo,G,J; Tridandapani,S; Carson,W,E. "Natural killer cells produce T cell-recruiting chemokines in response to antibody-coated tumor cells." CANCER RESEARCH. Vol. 66, no. 1. (January 2006.): 517-526.

Ai,J; Maturu,A; Johnson,W; Wang,Y,J; Marsh,C,B; Tridandapani,S. "The inositol phosphatase SHIP-2 down-regulates Fc gamma R-mediated phagocytosis in murine macrophages independently of SHIP-1." BLOOD. Vol. 107, no. 2. (January 2006.): 813-820.

Joshi,T; Ganesan,L,P; Cao,X,H; Tridandapani,S. "Molecular analysis of expression and function of hFc gamma RIIbl and b2 isoforms in myeloid cells." MOLECULAR IMMUNOLOGY. Vol. 43, no. 7. (March 2006.): 839-850.

Pengal,R,A; Ganesan,L,P; Wei,G; Fang,H,Q; Ostrowski,M,C; Tridandapani,S. "Lipopolysaccharide-induced production of interleukin-10 is promoted by the serine/threonine kinase Akt." MOLECULAR IMMUNOLOGY. Vol. 43, no. 10. (April 2006.): 1557-1564.

Kutala,Vijay,Kumar; Khan,Mahmood; Mandal,Rajarsi; Ganesan,Latha,P; Tridandapani,Susheela; Kalai,Tamas; Hideg,Kalman; Kuppusamy,Periannan. "Attenuation of myocardial ischemia-reperfusion injury by trimetazidine derivatives functionalized with antioxidant properties." JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS. Vol. 317, no. 3. (June 2006.): 921-928.

Roda,Julie,M; Parihar,Robin; Lehman,Amy; Mani,Aruna; Tridandapani,Susheela; Carson,William,E. "Interleukin-21 enhances NK cell activation in response to antibody-coated targets." JOURNAL OF IMMUNOLOGY. Vol. 177, no. 1. (July 2006.): 120-129.

Parsa,Kishore,VL; Ganesan,Latha,P; Rajaram,Murugesan,VS; Gavrilin,Mikhail,A; Balagopal,Ashwin; Mohapatra,Nrusingh,P; Wewers,Mark,D; Schlesinger,Larry,S; Gunn,John,S; Tridandapani,Susheela. "Macrophage pro-inflammatory response to Francisella novicida infection is regulated by SHIP." PLOS PATHOGENS. Vol. 2, no. 7. (July 2006.): 681-690.

Imhof,Diana; Wavreille,Anne-Sophie; May,Andreas; Zacharias,Martin; Tridandapani,Susheela; Pei,Dehua. "Sequence specificity of SHP-1 and SHP-2 Src homology 2 domains - Critical roles of residues beyond the pY+3 position." JOURNAL OF BIOLOGICAL CHEMISTRY. Vol. 281, no. 29. (July 2006.): 20271-20282.

Ganesan,Latha,P; Joshi,Trupti; Fang,Huiqing; Kutala,Vijay,Kumar; Roda,Julie; Trotta,Rossana; Lehman,Amy; Kuppusamy,Periannan; Byrd,John,C; Carson,William,E; Caligiuri,Michael,A; Tridandapani,Susheela. "Fc gamma R-induced production of superoxide and inflammatory cytokines is differentially regulated by SHIP through its influence on PI3K and/or Ras/Erk pathways." BLOOD. Vol. 108, no. 2. (July 2006.): 718-725.

Rajaram,Murugesan,VS; Ganesan,Latha,P; Parsa,Kishore,VL; Butchar,Jonathan,P; Gunn,John,S; Tridandapani,Susheela. "Akt/protein kinase B modulates macrophage inflammatory response to Francisella infection and confers a survival advantage in mice." JOURNAL OF IMMUNOLOGY. Vol. 177, no. 9. (November 2006.): 6317-6324.

Sardjono,Caroline,T; Harbour,Stacey,N; Yip,Jana,C; Paddock,Cathy; Tridandapani,Susheela; Newman,Peter,J; Jackson,Denise,E. "Palmitoylation at Cys(595) is essential for PECAM-I localisation into membrane microdomains and for efficient PECAM-I-mediated cytoprotection." THROMBOSIS AND HAEMOSTASIS. Vol. 96, no. 6. (December 2006.): 756-766.

Butchar,Jonathan,P; Parsa,Kishore,VL; Marsh,Clay,B; Tridandapani,Susheela. "Negative regulators of toll-like receptor 4-mediated macrophage inflammatory response." CURRENT PHARMACEUTICAL DESIGN. Vol. 12, no. 32. (January 2006.): 4143-4153.

Joshi,Trupti; Butchar,Jonathan,P; Tridandapani,Susheela. "Fc gamma receptor signaling in phagocytes." INTERNATIONAL JOURNAL OF HEMATOLOGY. Vol. 84, no. 3. (October 2006.): 210-216.

Khan,M; Varadharaj,S; Ganesan,L,P; Shobha,J,C; Naidu,M,U; Parinandi,N,L; Tridandapani,S; Kutala,V,K; Kuppusamy,P. "C-phycocyanin protects against ischemia-reperfusion injury of heart through involvement of p38 MAPK and ERK signaling." AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY. Vol. 290, no. 5. (May 2006.): H2136-H2145.

Mone,A,P; Cheney,C; Banks,A,L; Tridandapani,S; Mehter,N; Guster,S; Lin,T; Eisenbeis,C,F; Young,D,C; Byrd,J,C. "Alemtuzumab induces caspase-independent cell death in human chronic lymphocytic leukemia cells through a lipid raft-dependent mechanism." LEUKEMIA. Vol. 20, no. 2. (February 2006.): 272-279.

Wang,Yijie; Zeigler,Mandy,M; Lam,Gregory,K; Hunter,Melissa,G; Eubank,Tim,D; Khramtsov,Valery,V; Tridandapani,Susheela; Sen,Chandan,K; Sen,K; Marsh,Clay,B. "The role of the NADPH oxidase complex, p38 MAPK, and Akt in regulating human monocyte/macrophage survival." AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY. Vol. 36, no. 1. (January 2007.): 68-77.

Weir,Nathan,M; Selvendiran,Karuppaiyah; Kutala,Vijay,Kumar; Tong,Liyue; Vishwanath,Shilpa; Rajaram,Murugesan; Tridandapani,Susheela; Anant,Shrikant; Kuppusamy,Periannan. "Curcumin induces G2/M arrest and apoptosis in cisplatin-resistant human ovarian cancer cells by modulating Akt and p38 MAPK." CANCER BIOLOGY & THERAPY. Vol. 6, no. 2. (February 2007.): 178-184.

Butchar,Jonathan,P; Rajaram,Murugesan,VS; Ganesan,Latha,P; Parsa,Kishore,VL; Clay,Corey,D; Schlesinger,Larry,S; Tridandapani,Susheela. "Francisella tularensis induces IL-23 production in human monocytes." JOURNAL OF IMMUNOLOGY. Vol. 178, no. 7. (April 2007.): 4445-4454.

Zhao,Xiaobin; Lapalombella,Rosa; Joshi,Trupti; Cheney,Carolyn; Gowda,Aruna; Hayden-Ledbetter,Martha,S; Baurn,Peter,R; Lin,Thomas,S; Jarjoura,David; Lehman,Amy; Kussewitt,Donna; Lee,Robert,J; Caligiuri,Michael,A; Tridandapani,Susheela; Muthusamy,Natarajan; Byrd,John,C. "Targeting CD37-positive lymphoid malignancies with a novel engineered small modular immunopharmaceutical." BLOOD. Vol. 110, no. 7. (October 2007.): 2569-2577.

Roda,Julie,M; Joshi,Trupti; Butchar,Jonathan,P; McAlees,Jaclyn,W; Lehman,Amy; Tridandapani,Susheela; Carson,William,E. "The activation of natural killer cell effector functions by cetuximab-coated, epidermal growth factor receptor-positive tumor cells is enhanced by cytokines." CLINICAL CANCER RESEARCH. Vol. 13, no. 21. (November 2007.): 6419-6428.

Lapalombella,Rosa; Yu,Bo; Triantafillou,Georgia; Liu,Qing; Butchar,Jonathan,P; Lozanski,Gerard; Ramanunni,Asha; Smith,Lisa,L; Blum,William; Andritsos,Leslie; Wang,Da-Sheng; Lehman,Amy; Chen,Ching-Shih; Johnson,Amy,J; Marcucci,Guido; Lee,Robert,J; Lee,L,James; Tridandapani,Susheela; Muthusamy,Natarajan; Byrd,John,C. "Lenalidomide down-regulates the CD20 antigen and antagonizes direct and antibody-dependent cellular cytotoxicity of rituximab on primary chronic lymphocytic leukemia cells." BLOOD. Vol. 112, no. 13. (December 2008.): 5180-5189.

Henning,Lisa,N; Azad,Abul,K; Parsa,Kishore,VL; Crowther,Joy,E; Tridandapani,Susheela; Schlesinger,Larry,S. "Pulmonary surfactant protein a regulates TLR expression and activity in human macrophages." JOURNAL OF IMMUNOLOGY. Vol. 180, no. 12. (June 2008.): 7847-7858.

Kamen,Lynn,A; Levinsohn,Jonathan; Cadwallader,Amy; Tridandapani,Susheela; Swanson,Joel,A. "SHIP-1 increases early oxidative burst and regulates phagosome maturation in macrophages." JOURNAL OF IMMUNOLOGY. Vol. 180, no. 11. (June 2008.): 7497-7505.

Kondadasula,Sri,Vidya; Roda,Julie,M; Parihar,Robin; Yu,Jianhua; Lehman,Amy; Caligiuri,Michael,A; Tridandapani,Susheela; Burry,Richard,W; Carson,William,E. "Colocalization of the IL-12 receptor and Fc gamma RIIIa to natural killer cell lipid rafts leads to activation of ERK and enhanced production of interferon-gamma." BLOOD. Vol. 111, no. 8. (April 2008.): 4173-4183.

Butchar,Jonathan,P; Parsa,Kishore,VL; Marsh,Clay,B; Tridandapani,Susheela. "IFN gamma enhances IL-23 production during Francisella infection of human monocytes." FEBS LETTERS. Vol. 582, no. 7. (April 2008.): 1044-1048.

Gowda,Aruna; Roda,Julie; Hussain,Syed-Rehan,A; Ramanunni,Asha; Joshi,Trupti; Schmidt,Susan; Zhang,Xiaoli; Lehman,Amy; Jarjoura,David; Carson,William,E; Kindsvogel,Wayne; Cheney,Carolyn; Caligiuri,Michael,A; Tridandapani,Susheela; Muthusamy,Natarajan; Byrd,John,C. "IL-21 mediates apoptosis through up-regulation of the BH3 family member BIM and enhances both direct and antibody-dependent cellular cytotoxicity in primary chronic lymphocytic leukemia cells in vitro." BLOOD. Vol. 111, no. 9. (May 2008.): 4723-4730.

Parsa,Kishore,VL; Butchar,Jonathan,P; Rajaram,Murugesan,VS; Cremer,Thomas,J; Gunn,John,S; Schlesinger,Larry,S; Tridandapani,Susheela. "Francisella gains a survival advantage within mononuclear phagocytes by suppressing the host IFN gamma response." MOLECULAR IMMUNOLOGY. Vol. 45, no. 12. (July 2008.): 3428-3437.

Butchar,Jonathan,P; Cremer,Thomas,J; Clay,Corey,D; Gavrilin,Mikhail,A; Wewers,Mark,D; Marsh,Clay,B; Schlesinger,Larry,S; Tridandapani,Susheela. "Microarray Analysis of Human Monocytes Infected with Francisella tularensis Identifies New Targets of Host Response Subversion." PLOS ONE. Vol. 3, no. 8. (August 2008.): e2924-.

Cremer,Thomas,J; Tridandapani,Susheela. "Effective host response to Francisella tularensis requires functional mast cells." FUTURE MICROBIOLOGY. Vol. 3, no. 5. (October 2008.): 503-506.

Parsa, K.V.L., Butchar, J.P., Rajaram, M.V.S. and S. Tridandapani. "The tyrosine kinase Syk promotes the uptake of Francisella infection of human monocytes." Molecular Immunology. Vol. 45, no. 10. (January 2008.): 3012-3021.

Joshi,Trupti; Ganesan,Latha,P; Cheney,Carolyn; Ostrowski,Michael,C; Muthusamy,Natarajan; Byrd,John,C; Tridandapani,Susheela. "The PtdIns 3-Kinase/Akt Pathway Regulates Macrophage-Mediated ADCC against B Cell Lymphoma." PLOS ONE. Vol. 4, no. 1. (January 2009.): e4208-.

Cremer,Thomas,J; Amer,Amal; Tridandapani,Susheela; Butchar,Jonathan,P. "Francisella tularensis regulates autophagy-related host cell signaling pathways." AUTOPHAGY. Vol. 5, no. 1. (January 2009.): 125-128.

Cremer,Thomas,J; Ravneberg,David,H; Clay,Corey,D; Piper-Hunter,Melissa,G; Marsh,Clay,B; Elton,Terry,S; Gunn,John,S; Amer,Amal; Kanneganti,Thirumala-Devi; Schlesinger,Larry,S; Butchar,Jonathan,P; Tridandapani,Susheela. "MiR-155 induction by F. novicida but not the virulent F. tularensis results in SHIP down-regulation and enhanced pro-inflammatory cytokine response.." PloS one. Vol. 4, no. 12. (January 2009.): e8508-.

Cremer,Thomas,J; Ravneberg,David,H; Clay,Corey,D; Piper-Hunter,Melissa,G; Marsh,Clay,B; Elton,Terry,S; Gunns,John,S; Amer,Amal; Kanneganti,Thirumala-Devi; Schlesinger,Larry,S; Butchar,Jonathan,P; Tridandapani,Susheela. "M1R-155 Induction by F. novicida but Not the Virulent F. tularensis Results in SHIP Down-Regulation and Enhanced Pro-Inflammatory Cytokine Response." PLOS ONE. Vol. 4, no. 12. (December 2009.): e8508-.

Akhter,Anwari; Gavrilin,Mikhail,A; Frantz,Laura; Washington,Songcerae; Ditty,Cameron; Limoli,Dominique; Day,Colby; Sarkar,Anasuya; Newland,Christie; Butchar,Jonathan; Marsh,Clay,B; Wewers,Mark,D; Tridandapani,Susheela; Kanneganti,Thirumala-Devi; Amer,Amal,O. "Caspase-7 Activation by the Nlrc4/Ipaf Inflammasome Restricts Legionella pneumophila Infection." PLOS PATHOGENS. Vol. 5, no. 4. (April 2009.): e1000361-.

Rajaram,Murugesan,VS; Butchar,Jonathan,P; Parsa,Kishore,VL; Cremer,Thomas,J; Amer,Amal; Schlesinger,Larry,S; Tridandapani,Susheela. "Akt and SHIP Modulate Francisella Escape from the Phagosome and Induction of the Fas-Mediated Death Pathway." PLOS ONE. Vol. 4, no. 11. (November 2009.): e7919-.

Lapalombella,Rosa; Gowda,Aruna; Joshi,Trupti; Mehter,Najma; Cheney,Carolyn; Lehman,Amy; Chen,Ching-Shih; Johnson,Amy,J; Caligiuri,Michael,A; Tridandapani,Susheela; Muthusamy,Natarajan; Byrd,John,C. "The humanized CD40 antibody SGN-40 demonstrates pre-clinical activity that is enhanced by lenalidomide in chronic lymphocytic leukaemia." BRITISH JOURNAL OF HAEMATOLOGY. Vol. 144, no. 6. (March 2009.): 848-855.

Crouser,Elliott,D; Shao,Guohong; Julian,Mark,W; Macre,Jennifer,E; Shadel,Gerald,S; Tridandapani,Susheela; Huang,Qin; Wewers,Mark,D. "Monocyte activation by necrotic cells is promoted by mitochondrial proteins and formyl peptide receptors." CRITICAL CARE MEDICINE. Vol. 37, no. 6. (June 2009.): 2000-2009.

Butchar,Jonathan,P; Mehta,Payal; Justiniano,Steven,E; Guenterberg,Kristan,D; Kondadasula,Sri-Vidya; Mo,Xiaokui; Chemudupati,Mahesh; Kanneganti,Thirumala-Devi; Amer,Amal; Muthusamy,Natarajan; Jarjoura,David; Marsh,Clay,B; Carson,William,E; Byrd,John,C; Tridandapani,Susheela. "Reciprocal Regulation of Activating and Inhibitory Fc gamma Receptors by TLR7/8 Activation: Implications for Tumor Immunotherapy." CLINICAL CANCER RESEARCH. Vol. 16, no. 7. (April 2010.): 2065-2075.

Awan,Farrukh,T; Lapalombella,Rosa; Trotta,Rossana; Butchar,Jonathan,P; Yu,Bo; Benson,Don,M; Roda,Julie,M; Cheney,Carolyn; Mo,Xiaokui; Lehman,Amy; Jones,Jeffrey; Flynn,Joseph; Jarjoura,David; Desjarlais,John,R; Tridandapani,Susheela; Caligiuri,Michael,A; Muthusamy,Natarajan; Byrd,John,C. "CD19 targeting of chronic lymphocytic leukemia with a novel Fc-domain-engineered monoclonal antibody." BLOOD. Vol. 115, no. 6. (February 2010.): 1204-1213.

Cremer,Thomas,J; Shah,Prexy; Cormet-Boyaka,Estelle; Valvano,Miguel,A; Butchar,Jonathan,P; Tridandapani,Susheela. "Akt-Mediated Proinflammatory Response of Mononuclear Phagocytes Infected with Burkholderia cenocepacia Occurs by a Novel GSK3 beta-Dependent, I kappa B Kinase-Independent Mechanism." JOURNAL OF IMMUNOLOGY. Vol. 187, no. 2. (July 2011.): 635-643.

Mehta,Payal; Wavreille,Anne-Sophie; Justiniano,Steven,E; Marsh,Rachel,L; Yu,Jianhua; Burry,Richard,W; Jarjoura,David; Eubank,Timothy; Caligiuri,Michael,A; Butchar,Jonathan,P; Tridandapani,Susheela. "LyGDI, a Novel SHIP-Interacting Protein, Is a Negative Regulator of Fc gamma R-Mediated Phagocytosis." PLOS ONE. Vol. 6, no. 6. (June 2011.): e21175-.

Cremer,Thomas,John; Butchar,Jonathan,P; Tridandapani,Susheela. "Francisella Subverts Innate Immune Signaling: Focus On PI3K/Akt.." Frontiers in microbiology. Vol. 7, (January 2011.): 5-13.

Yu J, Mitsui T, Wei M, Mao H, Butchar JP, Shah MV, Zhang J, Mishra A, Alvarez-Breckenridge C, Liu X, Liu S, Yokohama A, Trotta R, Marcucci G, Benson DM Jr, Loughran TP Jr, Tridandapani S, Caligiuri MA.. "NKp46 identifies an NKT cell subset susceptible to leukemic transformation in mouse and human.." J Clin Invest.. Vol. 121(4), (January 2011.): 121(4):1456-70..

Rennolds,Jessica; Malireddy,Smitha; Hassan,Fatemat; Tridandapani,Susheela; Parinandi,Narasimham; Boyaka,Prosper,N; Cormet-Boyaka,Estelle. "Curcumin regulates airway epithelial cell cytokine responses to the pollutant cadmium." BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. Vol. 417, no. 1. (January 2012.): 256-261.

Cormet-Boyaka,Estelle; Jolivette,Kalyn; Bonnegarde-Bernard,Astrid; Rennolds,Jessica; Hassan,Fatemat; Mehta,Payal; Tridandapani,Susheela; Webster-Marketon,Jeanette; Boyaka,Prosper,N. "An NF-kappa B-Independent and Erk1/2-Dependent Mechanism Controls CXCL8/IL-8 Responses of Airway Epithelial Cells to Cadmium." TOXICOLOGICAL SCIENCES. Vol. 125, no. 2. (February 2012.): 418-429.

Cremer,Thomas,J; Fatehchand,Kavin; Shah,Prexy; Gillette,Devyn; Patel,Hemal; Marsh,Rachel,L; Besecker,Beth,Y; Rajaram,Murugesan,VS; Cormet-Boyaka,Estelle; Kanneganti,Thirumala-Devi; Schlesinger,Larry,S; Butchar,Jonathan,P; Tridandapani,Susheela. "MiR-155 induction by microbes/microbial ligands requires NE-kappa B-dependent de novo protein synthesis." FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY. Vol. 2, (June 2012.): /-.

Trotta,Rossana; Chen,Li; Ciarlariello,David; Josyula,Srirama; Mao,Charlene; Costinean,Stefan; Yu,Lianbo; Butchar,Jonathan,P; Tridandapani,Susheela; Croce,Carlo,M; Caligiuri,Michael,A. "miR-155 regulates IFN-gamma production in natural killer cells." BLOOD. Vol. 119, no. 15. (April 2012.): 3478-3485.

Trotta R, Chen L, Ciarlariello D, Josyula S, Mao C, Costinean S, Yu L, Butchar J, Tridandapani S, Croce C, Caligiuri M. "miR-155 regulates IFN-y production in natural killer cells." Blood. Vol. 119, no. 15. (January 2012.): 3478-3485.

Lapalombella,Rosa; Yeh,Yuh-Ying; Wang,Liwen; Ramanunni,Asha; Rafiq,Sarwish; Jha,Shruti; Staubli,Justin; Lucas,David,M; Mani,Rajeswaran; Herman,Sarah,EM; Johnson,Amy,J; Lozanski,Arletta; Andritsos,Leslie; Jones,Jeffrey; Flynn,Joseph,M; Lannutti,Brian; Thompson,Peter; Algate,Paul; Stromatt,Scott; Jarjoura,David; Mo,Xiaokui; Wang,Dasheng; Chen,Ching-Shih; Lozanski,Gerard; Heerema,Nyla,A; Tridandapani,Susheela; Freitas,Michael,A; Muthusamy,Natarajan; Byrd,John,C. "Tetraspanin CD37 Directly Mediates Transduction of Survival and Apoptotic Signals." CANCER CELL. Vol. 21, no. 5. (May 2012.): 694-708.

Gillette,Devyn,D; Shah,Prexy,A; Cremer,Thomas; Gavrilin,Mikhail,A; Besecker,Beth,Y; Sarkar,Anasuya; Knoell,Daren,L; Cormet-Boyaka,Estelle; Wewers,Mark,D; Butchar,Jonathan,P; Tridandapani,Susheela. "Analysis of Human Bronchial Epithelial Cell Proinflammatory Response to Burkholderia cenocepacia Infection INABILITY TO SECRETE IL-1 beta." JOURNAL OF BIOLOGICAL CHEMISTRY. Vol. 288, no. 6. (February 2013.): 3691-3695.

Shah,Prexy; Fatehchand,Kavin; Patel,Hemal; Fang,Huiqing; Justiniano,Steven,E; Mo,Xiaokui; Jarjoura,David; Tridandapani,Susheela; Butchar,Jonathan,P. "Toll-like Receptor 2 Ligands Regulate Monocyte Fc gamma Receptor Expression and Function." JOURNAL OF BIOLOGICAL CHEMISTRY. Vol. 288, no. 17. (April 2013.): 12345-12352.

Justiniano,Steven,E; Elavazhagan,Saranya; Fatehchand,Kavin; Shah,Prexy; Mehta,Payal; Roda,Julie,M; Mo,Xiaokui; Cheney,Carolyn; Hertlein,Erin; Eubank,Timothy,D; Marsh,Clay; Muthusamy,Natarajan; Butchar,Jonathan,P; Byrd,John,C; Tridandapani,Susheela. "Fc gamma Receptor-induced Soluble Vascular Endothelial Growth Factor Receptor-1 (VEGFR-1) Production Inhibits Angiogenesis and Enhances Efficacy of Anti-tumor Antibodies." JOURNAL OF BIOLOGICAL CHEMISTRY. Vol. 288, no. 37. (September 2013.): 26800-26809.

Ismail,Noura; Wang,Yijie; Dakhlallah,Duaa; Moldovan,Leni; Agarwal,Kitty; Batte,Kara; Shah,Prexy; Wisler,Jon; Eubank,Tim,D; Tridandapani,Susheela; Paulaitis,Michael,E; Piper,Melissa,G; Marsh,Clay,B. "Macrophage microvesicles induce macrophage differentiation and miR-223 transfer." BLOOD. Vol. 121, no. 6. (February 2013.): 984-995.

Rafiq,Sarwish; Butchar,Jonathan,P; Cheney,Carolyn; Mo,Xiaokui; Trotta,Rossana; Caligiuri,Michael; Jarjoura,David; Tridandapani,Susheela; Muthusamy,Natarajan; Byrd,John,C. "Comparative Assessment of Clinically Utilized CD20-Directed Antibodies in Chronic Lymphocytic Leukemia Cells Reveals Divergent NK Cell, Monocyte, and Macrophage Properties." JOURNAL OF IMMUNOLOGY. Vol. 190, no. 6. (March 2013.): 2702-2711.

Rafiq,Sarwish; Siadak,Anthony; Butchar,Jonathan,P; Cheney,Carolyn; Lozanski,Gerard; Jacob,Naduparambil,K; Lapalombella,Rosa; McGourty,Jackie; Moledor,Meghan; Lowe,Richard; Setter,Ben; Jones,Jeffrey; Flynn,Joseph,M; Andritsos,Leslie; Devine,Steven; Mo,Xiaokui; Jarjoura,David; Tridandapani,Susheela; Algate,Paul; Byrd,John,C; Muthusamy,Natarajan. "Glycovariant anti-CD37 monospecific protein therapeutic exhibits enhanced effector cell-mediated cytotoxicity against chronic and acute B cell malignancies." MABS. Vol. 5, no. 5. (September 2013.): 723-735.

Cheney CM, Stephens DM, Mo X, Rafiq S, Butchar J, Flynn JM, Jones JA, Maddocks K, O'Reilly A, Ramachandran A, Tridandapani S, Muthusamy N, Byrd JC. "Ocaratuzumab, an Fc-engineered antibody demonstrates enhanced antibody-dependent cell-mediated cytotoxicity in chronic lymphocytic leukemia." MAbs. Vol. 6, (March 2014.): 3-.

Alamuru NP, Behera S, Butchar JP, Tridanapani S, et al. "A novel immunomodulatory function of PHLPP1: inhibition of iNOS via attenuation of STAT1 ser727 phosphorylation in mouse macrophages." J Leukoc Biol.. Vol. ., (January 2014.): .-.

Gillette,Devyn,D; Tridandapani,Susheela; Butchar,Jonathan,P. "Monocyte/macrophage inflammatory response pathways to combat Francisella infection: possible therapeutic targets?." Frontiers in cellular and infection microbiology. Vol. 4, (January 2014.): 18-?.

Mehta, P. M., Butchar, J. P and Tridandapani, S. "Targeting SHIP to enhance immune therapy." Current Enzyme Inhibition. -.

Gillette DD, Tridandapani S, Butchar JP. "Therapeutic targeting of monocyte/macrophage inflammatory response pathways to combat Francisella infection." Frontiers in Microbiology. -.

Gillette DD, Cremer T, Ravneberg D, Curry HM, Fatehchand K, Shah, PA, Wewers MD, Schlesinger LS, Butchar JP, Tridandapani S, Gavrilin MA. "Virulent Type A Francisella tularensis actively suppresses cytokine responses in human monocytes." .. -.

 

Professional Activities

present PhD Thesis. University of Melbourne.
present PhD Thesis. Unviersity of Alberta.
2003 NIH / NCI, Review group NCI-C RTRB.
2003 NIH / NHLBI, HLBP Study Section.
2004 NIAID, IMS Special Emphasis Panel.
2004 NIAID/IMS Special Emphasis Panel.
2007 NIAID, ZAI1-BLG-M-J1 Scientific Review Group.
2007 NIAID ZAI1 LR-1 J1 Scientific Review Group.
2008 NIAID, ZA11-JSR-1-S2.
2008 KUMC R1.
2008 NIAID, ZA11-BLG-M-J1.
2008 ZAI1 BLG-M S1. NIAID.
2008 ZAI1-TP-1 (J1). NIAID.
2010 P01 Grant Review, Special Emphasis Panel. NIH.
2011 Lytmos Foundation Grant Reviewer. Lytmos Foundation.
2011 SEP ZAI1-LR-M-S1. NIAID.
2011 P01 Reviewer. NIAID.
2011 NIH Director's Innovator Award Reviewer. NIAID.
2013 CII Study Section. NCI.
2013 Centers of Excellence for Translational. NIAID.
2011 - 2014 NIH Director's New Innnovator Award Program. NIGMS.
2014 Cooperative Centers on Human Immunology (U19). NIAID.