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Stefan Niewiesk, DVM, PhD

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1900 Coffey Rd
Columbus, OH 43210

Phone: (614) 688-3605

Email: niewiesk.1@osu.edu


Current OSU Appointment

Professor, Veterinary Biosciences


Master/Graduate Advising


Journal Articles

Bankamp,B; Brinckmann,U,G; Reich,A; Niewiesk,S; ter Meulen,V; Liebert,U,G. "Measles virus nucleocapsid protein protects rats from encephalitis." JOURNAL OF VIROLOGY. Vol. 65, no. 4. (April 1991.): 1695-1700.

Reich,A; Erlwein,O; Niewiesk,S; ter Meulen,V; Liebert,U,G. "CD4+ T-cells control measles virus infection of the central nervous system." IMMUNOLOGY. Vol. 76, no. 2. (June 1992.): 185-191.

Niewiesk,S; Brinckmann,U; Bankamp,B; Sirak,S; Liebert,U,G; ter Meulen,V. "Susceptibility to measles virus-induced encephalitits in mice correlates with impaired antigen presentation to cytotoxic T lymphocytes." JOURNAL OF VIROLOGY. Vol. 67, no. 1. (January 1993.): 75-81.

Daenke,S; Parker,C,E; Niewiesk,S; Newsomdavis,J; Nightingale,S; Bangham,C,RM. "Spastic paraparesis in a patient carrying defective human T-cell leukemia virus type I (HTLV-I) provirus sequences but lacking a humoral or cytotoxic T-cell responses to HTLV-I." JOURNAL OF INFECTIOUS DISEASES. Vol. 169, no. 4. (April 1994.): 941-943.

Niewiesk,S; Daenke,S; Parker,C,E; Taylor,G; Weber,J; Nightingale,S; Bangham,C,RM. "The transactivator gene of human T-cell leukemia virus type I is more variable within and between healthy carriers than patients with tropical spastic paraparesis." JOURNAL OF VIROLOGY. Vol. 68, no. 10. (October 1994.): 6778-6781.

Niewiesk,S; Daenke,S; Parker,C,E; Taylor,G; Weber,J; Nightingale,S; Bangham,C,RM. "Naturally occurring variants of human T-cell leukemia virus type I Tax protein impair its recognition by cytotoxic T-lymphocytes and the transactivation function of Tax." JOURNAL OF VIROLOGY. Vol. 69, no. 4. (April 1995.): 2649-2653.

Niewiesk,S; Bangham,C,RM. "Evolution in a chronic RNA virus infection: Selection on HTLV-I tax protein differs between healthy carriers and patients with tropical spastic paraparesis." JOURNAL OF MOLECULAR EVOLUTION. Vol. 42, no. 4. (April 1996.): 452-458.

Niewiesk,S; Eisenhuth,I; Fooks,A; CLEGG,J,CS; Schnorr,J,J; Schneider-Schaulies,S; ter Meulen,V. "Measles virus-induced immune suppression in the cotton rat (Sigmodon hispidus) model depends on viral glycoproteins." JOURNAL OF VIROLOGY. Vol. 71, no. 10. (October 1997.): 7214-7219.

Niewiesk,S; Voelp,F; ter Meulen,V. "A maintenance and handling device for cotton rats (Sigmodon hispidus)." LAB ANIMAL. Vol. 26, no. 7. (July 1997.): 32-33.

Schmidt,M; Niewiesk,S; Heeney,J; Aguzzi,A; Rethwilm,A. "Mouse model to study the replication of primate foamy viruses." JOURNAL OF GENERAL VIROLOGY. Vol. 78, (August 1997.): 1929-1933.

Smith,R,ET; Niewiesk,S; Booth,S; Bangham,C,RM; Daenke,S. "Functional conservation of HTLV-1 rex balances the immune pressure for sequence variation in the Rex gene." VIROLOGY. Vol. 237, no. 2. (October 1997.): 397-403.

Niewiesk,S; Schneider-Schaulies,J; Ohnimus,H; Jassoy,C; Schneider-Schaulies,S; Diamond,L; Logan,J,S; ter Meulen,V. "CD46 expression does not overcome the intracellular block of measles virus replication in transgenic rats." JOURNAL OF VIROLOGY. Vol. 71, no. 10. (October 1997.): 7969-7973.

Fischer,N; Enssle,J; Muller,J; Rethwilm,A; Niewiesk,S. "Characterization of human foamy virus proteins expressed by recombinant vaccinia viruses." AIDS RESEARCH AND HUMAN RETROVIRUSES. Vol. 13, no. 6. (April 1997.): 517-521.

Neumeister,C; Niewiesk,S. "Recognition of measles virus-infected cells by CD8(+) T cells depends on the H-2 molecule." JOURNAL OF GENERAL VIROLOGY. Vol. 79, (November 1998.): 2583-2591.

Tober,C; Seufert,M; Schneider,H; Billeter,M,A; Johnston,I,CD; Niewiesk,S; ter Meulen,V; Schneider-Schaulies,S. "Expression of measles virus V protein is associated with pathogenicity and control of viral RNA synthesis." JOURNAL OF VIROLOGY. Vol. 72, no. 10. (October 1998.): 8124-8132.

Fooks,A,R; Jeevarajah,D; Lee,J; Warnes,A; Niewiesk,S; ter Meulen,V; Stephenson,J,R; Clegg,J,CS. "Oral or parenteral administration of replication-deficient adenoviruses expressing the measles virus haemagglutinin and fusion proteins: protective immune responses in rodents." JOURNAL OF GENERAL VIROLOGY. Vol. 79, (May 1998.): 1027-1031.

Niewiesk,S; Ohnimus,H; Schnorr,J,J; Gotzelmann,M; Schneider-Schaulies,S; Jassoy,C; ter Meulen,V. "Measles virus-induced immunosuppression in cotton rats is associated with cell cycle retardation in uninfected lymphocytes." JOURNAL OF GENERAL VIROLOGY. Vol. 80, (August 1999.): 2023-2029.

Schneider-Schaulies,J; Niewiesk,S; Schneider-Schaulies,S; ter Meulen,V. "Measles virus in the CNS: the role of viral and host factors for the establishment and maintenance of a persistent infection." JOURNAL OF NEUROVIROLOGY. Vol. 5, no. 6. (December 1999.): 613-622.

Niewiesk,S; Germann,P,G. "Development of neutralizing antibodies correlates with resolution of interstitial pneumonia after measles virus infection in cotton rats." JOURNAL OF EXPERIMENTAL ANIMAL SCIENCE. Vol. 40, no. 4. (January 2000.): 201-210.

Niewiesk,S; Gotzelmann,M; ter Meulen,V. "Selective in vivo suppression of T lymphocyte responses in experimental measles virus infection." PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. Vol. 97, no. 8. (April 2000.): 4251-4255.

Spreng,S; Gentschev,I; Goebel,W; Weidinger,G; ter Meulen,V; Niewiesk,S. "Salmonella vaccines secreting measles virus epitopes induce protective immune responses against measles virus encephalitis." MICROBES AND INFECTION. Vol. 2, no. 14. (November 2000.): 1687-1692.

Schlereth,B; Rose,J,K; Buonocore,L; ter Meulen,V; Niewiesk,S. "Successful vaccine-induced seroconversion by single-dose immunization in the presence of measles virus-specific maternal antibodies." JOURNAL OF VIROLOGY. Vol. 74, no. 10. (May 2000.): 4652-4657.

Schlereth,B; Germann,P,G; ter Meulen,V; Niewiesk,S. "DNA vaccination with both the haemagglutinin and fusion proteins but not the nucleocapsid protein protects against experimental measles virus infection." JOURNAL OF GENERAL VIROLOGY. Vol. 81, no. Pt 5. (May 2000.): 1321-1325.

Nanan,R; Rauch,A; Kampgen,E; Niewiesk,S; Kreth,H,W. "A novel sensitive approach for frequency analysis of measles virus-specific memory T-lymphocytes in healthy adults with a childhood history of natural measles." JOURNAL OF GENERAL VIROLOGY. Vol. 81, no. Pt 5. (May 2000.): 1313-1319.

Weidinger,G; Czub,S; Neumeister,C; Harriott,P; ter Meulen,V; Niewiesk,S. "Role of CD4(+) and CD8(+) T cells in the prevention of measles virus-induced encephalitis in mice." JOURNAL OF GENERAL VIROLOGY. Vol. 81, no. Pt 11. (November 2000.): 2707-2713.

Moeller,K; Duffy,I; Duprex,P; Rima,B; Beschorner,R; Fauser,S; Meyermann,R; Niewiesk,S; ter Meulen,V; Schneider-Schaulies,J. "Recombinant measles viruses expressing altered hemagglutinin (H) genes: Functional separation of mutations determining H antibody escape from neurovirulence." JOURNAL OF VIROLOGY. Vol. 75, no. 16. (August 2001.): 7612-7620.

Ohgimoto,S; Ohgimoto,K; Niewiesk,S; Klagge,I,M; Pfeuffer,J; Johnston,I,CD; Schneider-Schaulies,J; Weidmann,A; ter Meulen,V; Schneider-Schaulies,S. "The haemagglutinin protein is an important determinant of measles virus tropism for dendritic cells in vitro." JOURNAL OF GENERAL VIROLOGY. Vol. 82, no. Pt 8. (August 2001.): 1835-1844.

Weidinger,G; Ohlmann,M; Schlereth,B; Sutter,G; Niewiesk,S. "Vaccination with recombinant modified vaccinia virus Ankara protects against measles virus infection in the mouse and cotton rat model." VACCINE. Vol. 19, no. 20-22. (April 2001.): 2764-2768.

Weidinger,G; Henning,G; ter Meulen,V; Niewiesk,S. "Inhibition of major histocompatibility complex class II-dependent antigen presentation by neutralization of gamma interferon leads to breakdown of resistance against measles virus-induced encephalitis." JOURNAL OF VIROLOGY. Vol. 75, no. 7. (April 2001.): 3059-3065.

Moriabadi,N,F; Niewiesk,S; Kruse,N; Jung,S; Weissbrich,B; ter Meulen,V; Toyka,K,V; Rieckmann,P. "Influenza vaccination in MS - Absence of T-cell response against white matter proteins." NEUROLOGY. Vol. 56, no. 7. (April 2001.): 938-943.

Schneider-Schaulies,S; Niewiesk,S; Schneider-Schaulies,J; ter Meulen,V. "Measles virus induced immunosuppression: targets and effector mechanisms.." CURRENT MOLECULAR MEDICINE. Vol. 1, no. 2. (May 2001.): 163-181.

Neumeister,C; Nanan,R; Cornu,T,I; Luder,C,GK; ter Meulen,V; Naim,H; Niewiesk,S. "Measles virus and canine distemper virus target proteins into a TAP-independent MHC class I-restricted antigen-processing pathway." JOURNAL OF GENERAL VIROLOGY. Vol. 82, no. Pt 2. (February 2001.): 441-447.

Avota,E; Avots,A; Niewiesk,S; Kane,L,P; Bommhardt,U; ter Meulen,V; Schneider-Schaulies,S. "Disruption of Akt kinase activation is important for immunosuppression induced by measles virus." NATURE MEDICINE. Vol. 7, no. 6. (June 2001.): 725-731.

Niewiesk,S; Prince,G. "Diversifying animal models: the use of hispid cotton rats (Sigmodon hispidus) in infectious diseases." LABORATORY ANIMALS. Vol. 36, no. 4. (October 2002.): 357-372.

Schlereth,B; Buonocore,L; Tietz,A; ter Meulen,V; Rose,J,K; Niewiesk,S. "Successful mucosal immunization of cotton rats in the presence of measles virus-specific antibodies depends on degree of attenuation of vaccine vector and virus dose." JOURNAL OF GENERAL VIROLOGY. Vol. 84, no. Pt 8. (August 2003.): 2145-2151.

Pfeuffer,J; Puschel,K; ter Meulen,V; Schneider-Schaulies,J; Niewiesk,S. "Extent of measles virus spread and immune suppression differentiates between wild-type and vaccine strains in the cotton rat model (Sigmodon hispidus)." JOURNAL OF VIROLOGY. Vol. 77, no. 1. (January 2003.): 150-158.

Gundel,I; Weidinger,G; ter Meulen,V; Heesemann,A; Russmann,H; Niewiesk,S. "Oral immunization with recombinant Yersinia enterocolitica expressing a measles virus CD4 T cell epitope protects against measles virus-induced encephalitis." JOURNAL OF GENERAL VIROLOGY. Vol. 84, no. Pt 4. (April 2003.): 775-779.

Moll,M; Pfeuffer,J; Klenk,H,D; Niewiesk,S; Maisner,A. "Polarized glycoprotein targeting affects the spread of measles virus in vitro and in vivo." JOURNAL OF GENERAL VIROLOGY. Vol. 85, no. Pt 4. (April 2004.): 1019-1027.

Thomas,C,A; Carsillo,M; Niewiesk,S; Vasconcelos,D; Oglesbee,M. "Hyperthermic pre-conditioning promotes measles virus clearance from brain in a mouse model of persistent infection." BRAIN RESEARCH. Vol. 1004, no. 1-2. (April 2004.): 73-82.

Streif,S; Pueschel,K; Tietz,A; Blanco,J; ter Meulen,V; Niewiesk,S. "Effector CD8(+) T cells are suppressed by measles virus infection during delayed type hypersensitivity reaction." VIRAL IMMUNOLOGY. Vol. 17, no. 4. (January 2004.): 604-608.

Richter,B,WM; Onuska,J,M; Niewiesk,S; Prince,G,A; Eichelberger,M,C. "Antigen-dependent proliferation and cytokine induction in respiratory syncytial virus-infected cotton rats reflect the presence of effector-memory T cells." VIROLOGY. Vol. 337, no. 1. (June 2005.): 102-110.

Mahler,M; Heidtmann,W; Niewiesk,S; Gruber,A; Fossmark,R; Beil,W; Hedrich,H; Wagner,S. "Experimental Helicobacter pylori infection induces antral-predominant, chronic active gastritis in hispid cotton rats (Sigmodon hispidus)." HELICOBACTER. Vol. 10, no. 4. (August 2005.): 332-344.

Luhrmann,A; Tschernig,T; Pabst,R; Niewiesk,S. "Improved intranasal immunization with live-attenuated measles virus after co-inoculation of the lipopeptide MALP-2." VACCINE. Vol. 23, no. 39. (September 2005.): 4721-4726.

Santibanez,S; Niewiesk,S; Heider,A; Schneider-Schaulies,J; Berbers,G,AM; Zimmermann,A; Halenius,A; Wolbert,A; Deitemeier,I; Tischer,A; Hengel,H. "Probing neutralizing-anti body responses against emerging measles viruses (MVs): immune selection of MV by H protein-specific antibodies?." JOURNAL OF GENERAL VIROLOGY. Vol. 86, no. Pt 2. (February 2005.): 365-374.

Schubert,S; Moeller-Ehrlich,K; Singethan,K; Wiese,S; Duprex,W,P; Rima,B,K; Niewiesk,S; Schneider-Schaulies,J. "A mouse model of persistent brain infection with recombinant Measles virus." JOURNAL OF GENERAL VIROLOGY. Vol. 87, no. Pt 7. (July 2006.): 2011-2019.

Carsillo,Thomas; Traylor,Zachary; Choi,Changsun; Niewiesk,Stefan; Oglesbee,Michael. "hsp72, a host determinant of measles virus neurovirulence." JOURNAL OF VIROLOGY. Vol. 80, no. 22. (November 2006.): 11031-11039.

Carsillo,T; Zhang,X,S; Vasconcelos,D; Niewiesk,S; Oglesbee,M. "A single codon in the nucleocapsid protein C terminus contributes to in vitro and in vivo fitness of Edmonston measles virus." JOURNAL OF VIROLOGY. Vol. 80, no. 6. (March 2006.): 2904-2912.

Moeller-Ehrlich,K; Ludlow,M; Beschorner,R; Meyermann,R; Rima,B,K; Duprex,W,P; Niewiesk,S; Schneider-Schaulies,J. "Two functionally linked amino acids in the stem 2 region of measles virus haemagglutinin determine infectivity and virulence in the rodent central nervous system." JOURNAL OF GENERAL VIROLOGY. Vol. 88, (November 2007.): 3112-3120.

Hassantoufighi,A; Oglesbee,M; Richter,B,WM; Prince,G,A; Hemming,V; Niewiesk,S; Eichelberger,M,C. "Respiratory syncytial virus replication is prolonged by a concomitant allergic response." CLINICAL AND EXPERIMENTAL IMMUNOLOGY. Vol. 148, no. 2. (May 2007.): 218-229.

Pueschel,Karen; Tietz,Annette; Carsillo,Mary; Steward,Michael; Niewiesk,Stefan. "Measles virus-specific CD4 T-Cell activity does not correlate with protection against lung infection or viral clearance." JOURNAL OF VIROLOGY. Vol. 81, no. 16. (August 2007.): 8571-8578.

Carsillo,Thomas; Carsillo,Mary; Traylor,Zachary; Rajala-Schultz,Paeivi; Popovich,Phillip; Niewiesk,Stefan; Oglesbee,Michael. "Major Histocompatibility Complex Haplotype Determines hsp70-Dependent Protection against Measles Virus Neurovirulence." JOURNAL OF VIROLOGY. Vol. 83, no. 11. (June 2009.): 5544-5555.

Carsillo,Mary; Klapproth,Kay; Niewiesk,Stefan. "Cytokine Imbalance after Measles Virus Infection Has No Correlation with Immune Suppression." JOURNAL OF VIROLOGY. Vol. 83, (July 2009.): 7244-7251.

Parrula,C; Zimmerman,B; Nadella,P; Shu,S; Rosol,T; Fernandez,S; Lairmore,M; Niewiesk,S. "Expression of Tumor Invasion Factors Determines Systemic Engraftment and Induction of Humoral Hypercalcemia in a Mouse Model of Adult T-cell Leukemia." VETERINARY PATHOLOGY. Vol. 46, (September 2009.): 1003-1014.

Carsillo,Mary; Kutala,Vijay,Kumar; Puschel,Karen; Blanco,Jorge; Kuppusamy,Periannan; Niewiesk,Stefan. "Nitric oxide production and nitric oxide synthase type 2 expression by cotton rat (Sigmodon hispidus) macrophages reflect the same pattern as human macrophages." DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY. Vol. 33, (January 2009.): 718-724.

Rauch,Dan; Gross,Shimon; Harding,John; Bokhari,Sirosh; Niewiesk,Stefan; Lairmore,Michael; Piwnica-Worms,David; Ratner,Lee. "T-cell activation promotes tumorigenesis in inflammation-associated cancer." RETROVIROLOGY. Vol. 6, (December 2009.): 116-.

Palermo,Laura,M; Porotto,Matteo; Yokoyama,Christine,C; Palmer,Samantha,G; Mungall,Bruce,A; Greengard,Olga; Niewiesk,Stefan; Moscona,Anne. "Human Parainfluenza Virus Infection of the Airway Epithelium: Viral Hemagglutinin-Neuraminidase Regulates Fusion Protein Activation and Modulates Infectivity." JOURNAL OF VIROLOGY. Vol. 83, (July 2009.): 6900-6908.

Rauch,Dan; Gross,Shimon; Harding,John; Niewiesk,Stefan; Lairmore,Michael; Piwnica-Worms,David; Ratner,Lee. "Imaging spontaneous tumorigenesis: inflammation precedes development of peripheral NK tumors." BLOOD. Vol. 113, (February 2009.): 1493-1500.

Runkler,Nicole; Dietzel,Erik; Carsillo,Mary; Niewiesk,Stefan; Maisner,Andrea. "Sorting signals in the measles virus wild-type glycoproteins differently influence virus spread in polarized epithelia and lymphocytes." JOURNAL OF GENERAL VIROLOGY. Vol. 90, (October 2009.): 2474-2482.

Moscona,Anne; Porotto,Matteo; Palmer,Samantha; Tai,Caroline; Aschenbrenner,Lori; Triana-Baltzer,Gallen; Li,Qi-Xiang; Wurtman,David; Niewiesk,Stefan; Fang,Fang. "A Recombinant Sialidase Fusion Protein Effectively Inhibits Human Parainfluenza Viral Infection In Vitro and In Vivo." JOURNAL OF INFECTIOUS DISEASES. Vol. 202, (January 2010.): 234-241.

Bevin Zimmerman, Stefan Niewiesk, and Michael Lairmore. "Mouse Models of Human T Lymphotropic Virus Type-1 Associated Adult T-cell Leukemia/Lymphoma." VETERINARY PATHOLOGY. Vol. 47, (July 2010.): 677-689.

Perrone,Danielle; Bender,Scott; Niewiesk,Stefan. "A comparison of the immune responses of dogs exposed to canine distemper virus (CDV) - Differences between vaccinated and wild-type virus exposed dogs." CANADIAN JOURNAL OF VETERINARY RESEARCH-REVUE CANADIENNE DE RECHERCHE VETERINAIRE. Vol. 74, no. 3. (July 2010.): 214-217.

Rauch,Daniel,A; Hurchla,Michelle,A; Harding,John,C; Deng,Hongju; Shea,Lauren,K; Eagleton,Mark,C; Niewiesk,Stefan; Lairmore,Michael,D; Piwnica-Worms,David; Rosol,Thomas,J; Weber,Jason,D; Ratner,Lee; Weilbaecher,Katherine,N. "The ARF Tumor Suppressor Regulates Bone Remodeling and Osteosarcoma Development in Mice." PLOS ONE. Vol. 5, no. 12. (December 2010.): e15755-.

Carsillo,Mary; Kim,Dhohyung; Niewiesk,Stefan. "Role of AKT Kinase in Measles Virus Replication." JOURNAL OF VIROLOGY. Vol. 84, (February 2010.): 2180-2183.

Oglesbee,Michael; Niewiesk,Stefan. "Measles virus neurovirulence and host immunity." FUTURE VIROLOGY. Vol. 6, (January 2011.): 85-99.

Kim,Dhohyung; Martinez-Sobrido,Luis; Choi,Changsun; Petroff,Natasha; Garcia-Sastre,Adolfo; Niewiesk,Stefan; Carsillo,Thomas. "Induction of Type I Interferon Secretion through Recombinant Newcastle Disease Virus Expressing Measles Virus Hemagglutinin Stimulates Antibody Secretion in the Presence of Maternal Antibodies." JOURNAL OF VIROLOGY. Vol. 85, (January 2011.): 200-207.

Parrula,Cecilia; Fernandez,Soledad,A; Zimmerman,Bevin; Lairmore,Michael; Niewiesk,Stefan. "Measles virotherapy in a mouse model of adult T-cell leukaemia/lymphoma." JOURNAL OF GENERAL VIROLOGY. Vol. 92, (January 2011.): 1458-1466.

Kim,Dhohyung; Huey,Devra; Oglesbee,Michael; Niewiesk,Stefan. "Insights into the regulatory mechanism controlling the inhibition of vaccine-induced seroconversion by maternal antibodies." BLOOD. Vol. 117, (June 2011.): 6143-6151.