The Research Institute at Nationwide Children's Hospital
700 Childrens Dr, Room W512
Columbus, OH 43205
Phone: (614) 722-4062
Fax: (614) 722-2818
Email: Santiago.Partida-Sanchez@nationwidechildrens.org
Current OSU Appointment
Associate Professor, Pediatrics
Biographical Narrative
My major research interest is the study of immune cell recruitment induced during inflammation and/or infection. I received my PhD. degree in Immunology from the National Polytechnic Institute in 1998 (Mexico City, Mexico), and then I moved to The Trudeau Institute, Saranac Lake, NY, where I completed an extensive and productive postdoctoral training. In 2004, I joined the Center for Microbial pathogenesis at the Research Institute Nationwide Children's Hospital and Ohio State University. Currently, I serve as a faculty member of the Integrated Biosciences Graduate Program and the Graduate Program in Molecular, Cellular and Developmental Biology. During my assistant professorship I have continued my career as a productive scientist and well-known researcher in the fields of dendritic cell immunobiology and leukocyte motility. My studies have been published extensively in prestigious peer-reviewed journals. In addition, we have filed four patent applications based in our data, three of them have been issued and one more is pending. Overall, I believe my work has made a strong impact in our immunology research area. Currently, my research program focuses on the study of the molecular mechanisms by which the immune cell chemokine receptors control directional cell migration (chemotaxis). My goal is to design chemokine-signaling antagonists as therapeutics for inflammatory or infectious disease, and ultimately, to improve human health through research.
Bulletins and Technical Reports
Lund FE, Randall TD, Partida-Sanchez S. 2005. Methods for identifying compounds that inhibit CD38 activity. Vol. Official Gazette of the United States Patent and Trademark Office Patents. Alexandria, VA, USA: United States Patent and Trademark Office. [Peer Reviewed]
Lund FE, Randall TD, Partida-Sanchez S. 2010. Sm38 nucleic acid molecules.. Vol. Official Gazette of the United States Patent and Trademark Office Patents. Alexandria, VA, USA: United States Patent and Trademark Office. [Peer Reviewed]
Chapters In Books
Lund FE, Randall TD, Partida-Sánchez S. 2002. Regulation of Immune Responses by and cADPR. In Cyclic ADP-ribose and NAADP: Structures, Metabolism and Functions. 1st ed. Edited by Lee, HC. Boston, MA, United States: Kluwer Academic Publishers. 217-240.
Partida-Sánchez S, Nava-Rivero L, Shi G, and Lund FE. 2007. CD38: an ecto-enzyme at the crossroads of innate and adaptive immune responses. In Crossroads between Innate and Adaptive Immunity, Advances in Experimental Medicine and Biology. Vol. 590. Edited by Katsikis Peter D, Pulendran Bali, Schoenberger Steven P. New York, NY, United States: Springer US. 171-183.
Degrees
| 1991 | B.S., National Polytechnic Institute, Biochemistry & Microbiology |
| 1994 | M.S., National Polytechnic Institute, Immunology |
| 1998 | Ph.D., National Polytechnic Institute, Immunology |
| 2003 | Postdoctoral, Trudeau Institute |
Editorial Activities
Ad Hoc Manuscript Reviewer
| 2010 | Life Sciences. (Article) |
| 2009 | BMC Immunology. (Article) |
| 2008 | Journal of Leukocyte Biology. (Article) |
| 2007 | Nature Medicine. (Article) |
| 2007 | Molecular and Cellular Biochemistry. (Article) |
| 2007 | Cellular and Molecular Life Sciences. (Article) |
| 2006 | Blood. (Article) |
| 2006 | Archives of Medical Research. (Article) |
| 2005 | Journal of Immunology. (Article) |
Advisory Associate Editor
| 2010 - present | Clinical & Cellular Immunology. (Journal) |
Manuscript Ad Hoc Reviewer
| 2010 - present | Journal of immunology "Cutting edge section". (Article) |
| 2010 | Cellular Microbiology. (Article) |
Honors
| 1988 | High Honors, D.S. Examination. IPN, Conacyt, Mexico. |
| 1991 - 1994 | Fellow, Fellowship for M.S. National Council of Sciences. |
| 1994 | Fellow, High Honors, M.S. Examination. IPN, Conacyt, Mexico. |
| 1994 - 1998 | Fellow, Fellowship for Ph.D.. National Council of Sciences, Conacyt, Mexico. |
| 1998 - 2001 | Fellowship Candidate to national Investigator, National System of INvestor. |
| 2002 | AAI Minority Scientist Travel Award. AAI, New Orleans, LA. |
| 2006 | AAI Junior Faculty Travel Award. AAI Boston, MA. |
| 2007 | Carl Storm Underrepresented Minority(URM) Fellowship Program Travel Award. Gordon Research Conference, Tilton, NH. Subject: Travel Award to attend the Gordon Research Conference |
| 2010 | AAI Travel Grant for the 14th International Congress of Immunology in Kobe Japan. Congress of Immunology. |
| 2010 | FASEB-MARC Faculty Travel Award, 97th AAI Meeting in Baltimore, MD. AAI. |
Inventions and Patents
Lund, Frances E, Randall, Troy D, and Partida-Sanchez, Santiago, Inventor. filed October 17, 2001 and issued October 18, 2005. Methods for Identifying compounds that inhibit CD38 activity. patent no. U.S. Patent 6,955,884. U.S Patent office. http://ptft.uspto.gov/netacgi/nph-Parser?patentnumber=6%2c955%2c884.
Lund, Frances E, Randall, Troy D, Partida-Sanchez, Santiago, Inventor. filed 2005 and issued April 12, 2008. CD38 Modulated Chemotaxis. patent no. WO2006088951. WIPO. http://v3.espacenet.com/textdoc?DB=EPODOC&IDX=WO2006088951&F=0.
Frances E. Lund, Troy D. Randall, and Santiago Partida-Sanchez, Inventor. filed February 15, 2005 and issued April 13, 2010. SM38 NUCLEIC ACID MOLECULES. patent no. US 7,695,933 B2. www.uspto.gov/web/patents/patog/week15/OG/html/1353-2/US07695933-20100413.html.
Lund, Frances E., Partida-Sanchez, Santiago, Walseth, Tim, Inventor. filed October 1, 2007. (patent pending) TRPM2-Specific Inhibitors. patent no. WO2007082053. WIPO. http://v3.espacenet.com/textdoc?DB=EPODOC&IDX=WO2007082053&F=0.
Partida-Sanchez, Santiago, Robert Peterson. filed 2010. (patent pending) Tissue Disaggregator. patent no. B2312-282.
Languages
Spanish: (ability to read: Fluent, ability to write: Fluent, ability to speak: Fluent)
Peer Reviewed Journal Articles
Santos-Argumedo, L.; Kincade, P. W.; Partida-Sanchez, S.; Parkhouse, R. M. E. 1997. Cd44-stimulated dendrite formation ('spreading') in activated B cells. Immunology. Vol. 90, no. 1: 147-153. (IF: 3.67)
Partida-Sanchez, S.; Favila-Castillo, L.; Pedraza-Sanchez, S.; Gomez-Melgar, M.; Saul, A.; Estrada-Parra, S.; Estrada-Garcia, I. 1998. IgG antibody subclasses, tumor necrosis factor and Ifn-gamma levels in patients with type Ii lepra reaction on thalidomide treatment. International Archives of Allergy and Immunology. Vol. 116, no. 1: 60-66. (IF: 2.52)
Partida-Sanchez, S.; Garibay-Escobar, Adriana; Frixione, Eugenio; Parkhouse, R. M. E.; Santos-Argumedo, Leopoldo. 2000. Cd45r, Cd44 and Mhc class Ii are signaling molecules for the cytoskeleton-dependent induction of dendrites and motility in activated B cells. European Journal of Immunology. Vol. 30, no. 9: 2722-2728. (IF: 4.86)
Partida-Sanchez, S.; Cockayne, Debra A.; Monard, Simon; Jacobson, Elaine L.; Oppenheimer, Norman; Garvy, Beth; Kusser, Kim; Goodrich, Stephen; Howard, Maureen; Harmsen, Allen; Randall, Troy D.; Lund, Frances E. 2001. Cyclic Adp-ribose production by Cd38 regulates intracellular calcium release, extracellular calcium influx and chemotaxis in neutrophils and is required for bacterial clearance in vivo. Nature Medicine. Vol. 7, no. 11: 1209-1216. (IF: 28.58)
Lund, Frances E.; Partida-Sanchez, S.; Lee, Byung O.; Kusser, Kimberly L.; Hartson, Louise; Hogan, Robert J.; Woodland, David L.; Randall, Troy D. 2002. Lymphotoxin-alpha-deficient mice make delayed, but effective, T and B cell responses to influenza. Journal of Immunology. Vol. 169, no. 9: 5236-5243. (IF: 6.29)
Lund, Frances E.; Randall, Troy D.; Partida-Sanchez, Santiago. 2002. Does Neutrophil CD38 have a role in Calcium signaling triggered beta2 Integrin?. Nature Medicine. Vol. 8, no. 4. : 307-308. (IF: 28.58)
Moyron-Quiroz, J. E.; Partida-Sanchez, S.; Donis-Hernandez, R.; Sandoval-Montes, C.; Santos-Argumedo, L. 2002. Expression and function of Cd22, a B-cell restricted molecule. Scandinavian Journal of Immunology. Vol. 55, no. 4: 343-351. (IF: 2.18)
Partida-Sanchez, Santiago; Randall, Troy D.; Lund, Frances E. 2003. Innate immunity is regulated by Cd38, an ecto-enzyme with Adp-ribosyl cyclase activity. Microbes and Infection. Vol. 5, no. 1: 49-58. (IF: 3.12)
Partida-Sanchez, S, Goodrich S, Kusser KL, Oppenheimer N, Randall TD and Lund FE. 2004. Regulation of dendritic cell trafficking by the ADP-ribosyl cyclase CD38: Impact on the development of humoral immunity. Immunity. Vol. 20: 279-291. (IF: 20.57)
Partida-Sanchez, S; Iribarren, Pablo; Moreno-Garcia, Miguel E.; Gao, Ji-Liang; Murphy, Philip M.; Oppenheimer, Norman; Wang, Ji Ming; Lund, Frances E. 2004. Chemotaxis and calcium responses of phagocytes to formyl peptide receptor ligands is differentially regulated by cyclic Adp ribose. Journal of Immunology. Vol. 172, no. 3: 1896-1906. (IF: 6.29)
Moreno-Garcia, Miguel E.; Partida-Sanchez, Santiago; Primack, Julie; Sumoza-Toledo, Adriana; Muller-Steffner, Helene; Schuber, Francis; Oppenheimer, Norman; Lund, Frances E.; Santos-Argumedo, Leopoldo. 2004. Cd38 is expressed as noncovalently associated homodimers on the surface of murine B lymphocytes. European Journal of Biochemistry (FEBS J). Vol. 271, no. 5: 1025-1034. (IF: 3.57)
Khader, Shabaana A.; Partida-Sanchez, Santiago; Bell, Guy; Jelley-Gibbs, Dawn M.; Swain, Susan; Pearl, John E.; Ghilardi, Nico; deSauvage, Frederic J.; Lund, Frances E.; Cooper, Andrea M. 2006. Interleukin 12p40 is required for dendritic cell migration and T cell priming after Mycobacterium tuberculosis infection. Journal of Experimental Medicine. Vol. 203, no. 7: 1805-1815. (IF: 15.21)
Lund, Frances E.; Muller-Steffner, Helene; Romero-Ramirez, Hector; Moreno-Garcia, Miguel E.; Partida-Sanchez, Santiago.; Makris, Melissa; Oppenheimer, Norman J.; Santos-Argumedo, Leopoldo; Schuber, Francis. 2006. Cd38 induces apoptosis of a murine pro-b leukemic cell line by a tyrosine kinase-dependent but Adp-ribosyl cyclase- and Nad glycohydrolase-independent mechanism. International Immunology. Vol. 18, no. 7: 1029-1042. (IF: 3.18)
Massullo, Pam; Sumoza-Toledo, Adriana; Bhagat, Harivadan; Partida-Sanchez, Santiago. 2006. Trpm channels, calcium and redox sensors during innate immune responses. Seminars in Cell & Developmental Biology. Vol. 17, no. 6: 654-666. (IF: 8.67)
Partida-Sanchez, S., Nava-Rivero L, Shi G, and Lund FE. 2007. Cd38 an ecto-enzyme at the crossroads of innate and adaptive immune response. Adv Exp Med Biol. Vol. 590: 171-183. (IF: 1.67)
Partida-Sanchez, Santiago; Gasser, Andreas; Fliegert, Ralf; Siebrands, Cornelia C.; Dammermann, Werner; Shi, Guixiu; Mousseau, Betty J.; Sumoza-Toledo, Adriana; Bhagat, Harivadan; Walseth, Timothy F.; Guse, Andreas H.; Lund, Frances E. 2007. Chemotaxis of mouse bone marrow neutrophils and dendritic cells is controlled by Adp-ribose, the major product generated by the Cd38 enzyme reaction. Journal of Immunology. Vol. 179, no. 11: 7827-7839. (IF: 6.29)
Shi, Guixiu; Partida-Sanchez, Santiago; Misra, Ravi S.; Tighe, Michael; Borchers, Michael T.; Lee, James J.; Simon, Melvin I.; Lund, Frances E. 2007. Identification of an alternative G alpha(q)-dependent chemokine receptor signal transduction pathway in dendritic cells and granulocytes. Journal of Experimental Medicine. Vol. 204, no. 11: 2705-2718. (IF: 15.21)
Novotny, Laura A.; Partida-Sanchez, Santiago; Munson, Robert S., Jr.; Bakaletz, Lauren O. 2008. Differential uptake and processing of a Haemophilus influenzae P5-derived immunogen by chinchilla dendritic cells. Infection and Immunity. Vol. 76, no. 3: 967-977.
Randolph, Gwendalyn J.; Ochando, Jordi; Partida-Sanchez, Santiago. 2008. Migration of dendritic cell subsets and their precursors. Annual Review of Immunology. Vol. 26: 293-316. (IF: 47.23)
Lange, Ingo; Yamamoto, Shinichiro; Partida-Sanchez, Santiago; Mori, Yasuo; Fleig, Andrea; Penner, Reinhold. 2009. Trpm2 Functions as a Lysosomal Ca2+-release Channel in beta Cells. Science Signaling. Vol. 2, no. 71: Article No.: ra23. (IF: 30)
Lund FE, Randall TD, Partida-Sanchez S. 2010. Sm38 nucleic acid molecules. Official Gazette of the United States Patent and Trademark. (March 14)
Horvath DJ, Li Rollin, Casper, T, Partida-Sanchez S, Hustad DA, Hultgren SJ and Justice SS. 2010. Morphological Plasticity Promotes Resistance to Phagocyte Killing of Uropathogenic Escherichia coli.. Microbes and Infection. (December 21) (Formally Accepted)
Positions
| 1993 - 1998 | Research Assistant, National Polytechnic Institute, Department of Cell Biology, Research and Advanced Studies Center. Mexico City, Mexico. |
| 1994 - 1998 | Pre-Doctoral Fellow, (Ph.D. program), National Polytechnic Institute, Department of Immunology & Department of Cell Biology, Research and Advanced Studies Center. Mexico City, Mexico. |
| 1998 - 2003 | Post-Doctoral Fellow, Trudeau Institute. Saranac Lake, NY, United States. |
| 2003 - 2004 | Research Scientist, Trudeau Institute. Saranac Lake, NY, United States. |
| 2004 - present | Assistant Professor, Research Institute at Nationwide Children's Hospital & The Ohio State University, College of Medicine, The Ohio State University, Department of Pediatrics. Columbus, OH, United States. |
| 2005 - present | Graduate Faculty, The Ohio State University, Integrated Biomedical Science Graduate Program & Molecular, Cellular and Developmental Biology Program. Columbus, OH, United States. |
Reviews
Randolph GJ, Ochando J and Partida-Sánchez S. 2008. Migration of dendritic cell subsets and their precursors. Review of Dendritic Cells. Annual Review of Immunology. Vol. 26: Annual Reviews. (April): 293-331. (47.23) [Peer Reviewed] (Published)