Ohio State Navbar

People

Santiago Partida-Sanchez, PhD


Staff photo

700 Childrens Dr
Center for Microbial Pathogenesis
Columbus, OH 43205

Phone: (614) 722-4062

Email: partida-sanchez.1@osu.edu

 

Current OSU Appointment

Associate Professor, Pediatrics

 

Biographical

My major research interest is the study of immune cell recruitment induced during inflammation and/or infection. I received my PhD. degree in Immunology from the National Polytechnic Institute in 1998 (Mexico City, Mexico), and then I moved to The Trudeau Institute, Saranac Lake, NY, where I completed an extensive and productive postdoctoral training. In 2004, I joined the Center for Microbial pathogenesis at the Research Institute Nationwide Children’s Hospital and Ohio State University. Currently, I serve as a faculty member of the Integrated Biosciences Graduate Program and the Graduate Program in Molecular, Cellular and Developmental Biology. During my assistant professorship I have continued my career as a productive scientist and well-known researcher in the fields of dendritic cell immunobiology and leukocyte motility. My studies have been published extensively in prestigious peer-reviewed journals. In addition, we have filed four patent applications based in our data, three of them have been issued and one more is pending. Overall, I believe my work has made a strong impact in our immunology research area. Currently, my research program focuses on the study of the molecular mechanisms by which the immune cell chemokine receptors control directional cell migration (chemotaxis). My goal is to design chemokine-signaling antagonists as therapeutics for inflammatory or infectious disease, and ultimately, to improve human health through research.

Chapters in Books

Lund FE, Randall TD, Partida-Sánchez S.. "Regulation of Immune Responses by and cADPR." In Cyclic ADP-ribose and NAADP: Structures, Metabolism and Functions. 1st ed. Edited by Lee, HC. 217-240. Boston, MA, US|USA: Kluwer Academic Publishers, January 2002.

Partida-Sánchez S, Nava-Rivero L, Shi G, and Lund FE. "CD38: an ecto-enzyme at the crossroads of innate and adaptive immune responses." In Crossroads between Innate and Adaptive Immunity, Advances in Experimental Medicine and Biology. Vol. 590. Edited by Katsikis Peter D, Pulendran Bali, Schoenberger Steven P. 171-183. New York, NY, US|USA: Springer US, January 2007.

 

Conferences

Partida-Sánchez, S, Favila L, Pedraza S, Estrada-Parra S, Estrada-Garcia I and Saul A.. "Tumor Necrosis Factor (TNF) in leprosy patients with type II reaction." The 14th International Leprosy Congress. (August 1993). 101-102A.

Randall T.D., Kusser, K., Primack, J., Partida-Sanchez, S., Lee, B.O., Harmsen, A., and Lund, F.E.. "B cell responses to influenza develop more rapidly in the lung than in systemic sites.." In FASEB Journal. (April 2000). A1191-A1197.

Partida-Sánchez, S., Harmsen, A., Garvy ,B., Randall,T., Lund, F.E.. "A new emergent role for CD38 during innate immune responses.." In FASEB Journal. (April 2000). A1151-A1151.

Partida-Sánchez, S., Cockayne, D., Jacobson, E., Garvy, B., Harmsen, A., Randall, T.D., and Lund, F.E.. "Production of cADPR by CD38 controls capacitative calcium influx and neutrophil chemotaxis to bacterial chemoattractants and is required for bacterial clearance.." The 11th International Congress of Immunology. (July 2001). .

Partida-Sanchez, S., Cockayne, D., Monard, S., Jacobson, E.L., Garvy, B., Randall, T., Lund, F.E.. "CD38 catalyzed cADPR controls neutrophil chemotaxis, calcium influx and bacterial clearance.." In FASEB Journal. (March 2001). A650-A650.

Partida-Sánchez, S., Randall, T.D. and Lund, F.E.. "CD38 regulates immune responses by modulating T cell priming by antigen-presenting cells.." In FASEB Journal. (April 2002). A1227-.

Partida-Sánchez, S., Fliegert, R., Gasser, A., Bhagat, H., Walseth, T. F., Guse, A. H., Lund, F. E.. "CD38 initiates allergic airway inflammation by regulating T cell priming." In FASEB Journal. (April 2003). C14-C14.

Rivero-Nava, L. Partida-Sánchez, S., Randall, TD. Lund, FE.,. "CD38 Regulates Trafficking of TNF-alpha-Producing Dendritic Cells after Listeria monocytogenes Infection.." The 12th International Congress of Immunology. (July 2004). .

Partida-Sánchez, S., Goodrich, SP., Kusser, K., Oppenheimer, N., Randall, TD. Lund, FE.. "Regulation of dendritic cell trafficking by the ADP-Ribosyl cyclase CD38: impact on the development of humoral immunity.." The 12th International Congress of Immunology. (July 2004). .

Partida-Sánchez, S., Fliegert R., Gasser A., Bhagat H., Guse AH., Walseth TF., Guse AH., and Lund FE.. "Regulation of Ca2+ signaling and chemotaxis in phagocytes by ADPR, a novel second messenger in immune cells.." In Journal of Immunology. (April 2006). S40-.

Partida-Sanchez, S., Gasser,A., Fliegert R, Sumoza-Toledo A , B. H., Shi, G., Walseth T.F., Guse A.H., Lund F.E.. "CD38 enzymatic products cADPR and ADPR control Ca2+ influx and leukocyte chemotaxis through TRPM2 cation channels.." In Molecular Medicine. (January 2006). S19-S19.

Randall , T.D., Rivero-Nava L.E., Guedes A.G.P., Partida-Sánchez, S., Kannan, M.S., Lund, F.E.. "Regulation of allergic airway disease by CD38: Roles for CD38 in T cell priming, Th2 effector cell generation and airway hyperresponsiveness.." In Molecular Medicine. (January 2006). S21-S21.

Partida-Sanchez,Santiago; Rivero-Nava,Laura; Shi,Guixiu; Lund,Frances,E. "CD38: An ecto-enzyme at the crossroads of innate and adaptive immune responses." CROSSROADS BETWEEN INNATE AND ADAPTIVE IMMUNITY. (January 2007). 171-183.

Siebrands, C.C., Dammermann, W., Fliegert, R., Partida-Sanchez, S., Walseth, T.F., Lund, F.E., and Lonati, C.. "8Br-ADPR: A Novel Antagonist of TRPM2 Channels.." Fall Meeting German Society of Biochemistry and Molecular Biology. (September 2007). .

Partida-Sanchez S,, Sumoza-Toledo, A., Bhagat, H., Lange, I., Penner, R., and Fleig, A.. "Azole derivative drugs inhibit neutrophil chemotaxis by blocking the Calcium permeant channel TRPM2." J. Immunol. Proceedings of the 97th AAI Meeting in Baltimore, MD.. (January 2010). .

Sumoza-Toledo A, Lange I, Bhagat H, Cortado H, Mori Y, Penner R, Fleig A, Partida-Sanchez S,.. "Transient Receptor Potential Melastatin 2 (TRPM2) is a Calcium Release Channel Essential for Chemotaxis of Dendritic Cells." J Immunol. Proceddings of the 97th AAI Meeting in Baltimore, MD.. (January 2010). .

 

Degrees

1991 B.S., National Polytechnic Institute

1994 M.S., National Polytechnic Institute

1998 Ph.D., National Polytechnic Institute

 

Editorial Activities

2005 - present Journal of Immunology
2006 - present Archives of Medical Research
2006 - present Blood
2007 - present Cellular and Molecular Life Sciences
2007 - present Nature Medicine
2007 - present Molecular and Cellular Biochemistry
2008 - present Journal of Leukocyte Biology
2009 - present BMC Immunology
2010 - present Life Sciences
2010 - present Journal of immunology "Cutting edge section"
2010 - present Cellular Microbiology
2010 - present Clinical & Cellular Immunology
 

Honors

1988 - present High Honors, D.S. Examination.
1991 - 1994 Fellowship for M.S. National Council of Sciences.
1994 - present High Honors, M.S. Examination.
1994 - 1998 Fellowship for Ph.D..
1998 - 2001 Fellowship Candidate to national Investigator, National System of INvestor.
2002 - present AAI Minority Scientist Travel Award. AAI, New Orleans, LA.
2006 - present AAI Junior Faculty Travel Award. AAI Boston, MA.
2007 - present Carl Storm Underrepresented Minority(URM) Fellowship Program Travel Award. Gordon Research Conference, Tilton, NH.
2010 - present FASEB-MARC Faculty Travel Award, 97th AAI Meeting in Baltimore, MD. AAI.
2010 - present AAI Travel Grant for the 14th International Congress of Immunology in Kobe Japan. Congress of Immunology.
2013 AAI Laboratory Travel Grant, AAI 2013, Centennial Meeting. American Association of Immunologists.
 

Journal Articles

Santos-Argumedo L, Kincade PW, Partida-Sanchez S, Parkhouse RME. "CD44-stimulated dendrite formation ('spreading') in activated B cells." Immunology. Vol. 90, no. 1. (January 1997.): 147-153.

Partida-Sanchez S, Favila-Castillo L, Pedraza-Sanchez S, Gomez-Melgar M, Saul A, Estrada-Parra S, Estrada-Garcia I. "IgG antibody subclasses, tumor necrosis factor and Ifn-gamma levels in patients with type Ii lepra reaction on thalidomide treatment." International Archives of Allergy and Immunology. Vol. 116, no. 1. (January 1998.): 60-66.

Partida-Sanchez S, Harmsen A, Garvy B, Randall T, Lund FE. "A new emergent role for CD38 during innate immune responses." FASEB Journal. Vol. 14, no. 6. (April 2000.): A1151-A1151.

Partida-Sanchez S, Garibay-Escobar A, Frixione E, Parkhouse RME, Santos-Argumedo L. "CD45r, CD44 and MHC class Ii are signaling molecules for the cytoskeleton-dependent induction of dendrites and motility in activated B cells." European Journal of Immunology. Vol. 30, no. 9. (January 2000.): 2722-2728.

Partida-Sanchez S, Cockayne DA, Monard S, Jacobson EL, Oppenheimer N, Garvy B, Kusser K, Goodrich S, Howard M, Harmsen A, Randall TD, Lund FE. "Cyclic ADP-ribose production by CD38 regulates intracellular calcium release, extracellular calcium influx and chemotaxis in neutrophils and is required for bacterial clearance in vivo." Nature Medicine. Vol. 7, no. 11. (January 2001.): 1209-1216.

Partida-Sanchez S, Randall TD, Lund FE. "CD38 regulates immune responses by modulating T cell priming by antigen-presenting cells." FASEB Journal. Vol. 16, no. 5. (March 2002.): A1227-A1227.

Lund FE. Randall TD, Partida-Sanchez S. "Does neutrophil CD38 have a role in calcium signaling triggered beta2 integrin?." Nature Medicine. Vol. 8, no. 4. (January 2002.): 307-308.

Moyron-Quiroz JE, Partida-Sanchez S, Donis-Hernandez R, Sandoval-Montes C, Santos-Argumedo L. "Expression and function of CD22, a B-cell restricted molecule." Scandinavian Journal of Immunology. Vol. 55, no. 4. (January 2002.): 343-351.

Lund FE, Partida-Sanchez S, Lee BO, Kusser KL, Hartson L, Hogan RJ, Woodland DL, Randall TD. "Lymphotoxin-alpha-deficient mice make delayed, but effective, T and B cell responses to influenza." Journal of Immunology. Vol. 169, no. 9. (January 2002.): 5236-5243.

Rivero-Nava L, Partida-Sanchez S, Randall T, Lund FE. "CD38 initiates allergic airway inflammation by regulating T cell priming." FASEB Journal. Vol. 17, no. 7. (April 2003.): C14-C14.

Partida-Sanchez S, Randall TD, Lund FE. "Innate immunity is regulated by CD38, an ecto-enzyme with ADP-ribosyl cyclase activity." Microbes and Infection. Vol. 5, no. 1. (January 2003.): 49-58.

Moreno-Garcia ME, Partida-Sanchez S, Primack J, Sumoza-Toledo A, Muller-Steffner H, Schuber F, Oppenheimer N, Lund FE, Santos-Argumedo L. "CD38 is expressed as noncovalently associated homodimers on the surface of murine B lymphocytes." European Journal of Biochemistry. Vol. 271, no. 5. (January 2004.): 1025-1034.

Partida-Sanchez S, Goodrich S, Kusser KL, Oppenheimer N, Randall TD, Lund FE. "Regulation of dendritic cell trafficking by the ADP-ribosyl cyclase CD38: Impact on the development of humoral immunity." Immunity. Vol. 20, (January 2004.): 279-291.

Partida-Sanchez S, Iribarren P, Moreno-Garcia ME, Gao JL, Murphy PM, Oppenheimer N, Wang JM, Lund FE. "Chemotaxis and calcium responses of phagocytes to formyl peptide receptor ligands is differentially regulated by cyclic ADP ribose.." Journal of Immunology. Vol. 172, no. 3. (January 2004.): 1896-1906.

Randall TD, Rivero-Nava LE, Guedes AGP, Partida-Sanchez S, Kannan MS, Lund FE. "Regulation of allergic airway disease by CD38: Roles for CD38 in T cell priming, Th2 effector cell generation and airway hyperresponsiveness." Molecular Medicine. Vol. 12, (January 2006.): S21-S21.

Partida-Sanchez S, Gasser A, Fliegert R, Sumoza-Toledo A, Bhagat H, Shi G, Walseth TF, Guse AH, Lund FE. "CD38 enzymatic products cADPR and ADPR control Ca2+ influx and leukocyte chemotaxis through TRPM2 cation channels." Molecular Medicine. Vol. 12, (January 2006.): S19-S19.

Partida-Sanchez S, Fliegert R, Gasser A, Bhagat H, Walseth TF, Guse AH, Lund FE. "Regulation of Ca2+ signaling and chemotaxis in phagocytes by ADPR, a novel second messenger in immune cells." Journal of Immunology. Vol. 176, (April 2006.): S40-S40.

Khader SA, Partida-Sanchez S, Bell G, Jelley-Gibbs DM, Swain S, Pearl JE, Ghilardi N, deSauvage FJ, Lund FE, Cooper AM. "Interleukin 12p40 is required for dendritic cell migration and T cell priming after Mycobacterium tuberculosis infection." Journal of Experimental Medicine. Vol. 203, no. 7. (January 2006.): 1805-1815.

Massullo P, Sumoza-Toledo A, Bhagat H, Partida-Sanchez S. "TRPM channels, calcium and redox sensors during innate immune responses." Seminars in Cell & Developmental Biology. Vol. 17, no. 6. (January 2006.): 654-666.

Lund FE, Muller-Steffner H, Romero-Ramirez H, Moreno-Garcia ME, Partida-Sanchez S, Makris M, Oppenheimer NJ, Santos-Argumedo L, Schuber F. "CD38 induces apoptosis of a murine pro-b leukemic cell line by a tyrosine kinase-dependent but ADP-ribosyl cyclase- and NAD glycohydrolase-independent mechanism." International Immunology. Vol. 18, no. 7. (January 2006.): 1029-1042.

Partida-Sanchez S, Nava-Rivero L, Shi G, Lund FE. "CD38 an ecto-enzyme at the crossroads of innate and adaptive immune response." Advances in Experimental Medicine and Biology. Vol. 590, (January 2007.): 171-183.

Partida-Sanchez S, Rivero-Nava L, Shi G, Lund FE. "CD38: An ecto-enzyme at the crossroads of innate and adaptive immune responses." Crossroads Between Innate and Adaptive Immunity. Vol. 590, (January 2007.): 171-183.

Shi G, Partida-Sanchez S, Misra RS, Tighe M, Borchers MT, Lee JJ, Simon MI, Lund FE. "Identification of an alternative G alpha(q)-dependent chemokine receptor signal transduction pathway in dendritic cells and granulocytes." Journal of Experimental Medicine. Vol. 204, no. 11. (January 2007.): 2705-2718.

Partida-Sanchez S, Gasser A, Fliegert R, Siebrands CC, Dammermann W, Shi G, Mousseau BJ, Sumoza-Toledo A, Bhagat H, Walseth TF, Guse AH, Lund FE. "Chemotaxis of mouse bone marrow neutrophils and dendritic cells is controlled by Adp-ribose, the major product generated by the Cd38 enzyme reaction." Journal of Immunology. Vol. 179, no. 11. (January 2007.): 7827-7839.

Randolph GJ, Ochando J and Partida-Sánchez S. "Migration of dendritic cell subsets and their precursors.." Annual Review of Immunology. Vol. 26, (April 2008.): 293-331.

Randolph GJ, Ochando J, Partida-Sanchez S. "Migration of dendritic cell subsets and their precursors." Annual Review of Immunology. Vol. 26, (January 2008.): 293-316.

Novotny LA, Partida-Sanchez S, Munson RS Jr, Bakaletz LO. "Differential uptake and processing of a Haemophilus influenzae P5-derived immunogen by chinchilla dendritic cells." Infection and Immunity. Vol. 76, no. 3. (January 2008.): 967-977.

Lange I, Yamamoto S, Partida-Sanchez S, Mori Y, Fleig A, Penner R. "TRPM2 functions as a lysosomal Ca2+-release channel in beta cells." Science Signaling. Vol. 2, no. 71. (January 2009.): Article No.: ra23-.

Lund FE, Randall TD, Partida-Sanchez S. "Sm38 nucleic acid molecules." Official Gazette of the United States Patent and Trademark. (March 2010.): -.

Sumoza-Toledo A, Lange I, Cortado H, Bhagat H, Mori Y, Fleig A, Penner R, Partida-Sanchez S. "Dendritic cell maturation and chemotaxis is regulated by TRPM2-mediated lysosomal Ca2+ release." FASEB Journal. Vol. 25, no. 10. (October 2011.): 3529-3542.

Horvath DJ, Li Rollin, Casper, T, Partida-Sanchez S, Hustad DA, Hultgren SJ and Justice SS.. "Morphological plasticity promotes resistance to phagocyte killing of uropathogenic Escherichia coli." Microbes and Infection. Vol. 13, no. 5. (January 2011.): 426-437.

Partida-Sanchez S, Horvath D, Cortado H, Li B, Flano E, Justice S. "Monocyte-derived inflammatory dendritic cells expressing CX3CR1hi control urinary tract infection in mice." Journal of Immunology. Vol. 188, (May 2012.): 120.25-.

Hans CP, Koenig SN, Huang N, Cheng J, Beceiro S, Guggilam A, Kuivaniemi H, Partida-Sanchez S, Garg V. "Inhibition of Notch1 signaling reduces abdominal aortic aneurysm in mice by attenuating macrophage-mediated inflammation." Arteriosclerosis, Thrombosis and Vascular Biology. Vol. 32, no. 12. (December 2012.): 3012-23.

McNally B, Willette M, Ye F, Partida-Sanchez S, Flano E. "Intranasal administration of dsRNA analog poly(I:C) induces interferon-alpha receptor-dependent accumulation of antigen axperienced T cells in the airways." PLoS One. Vol. 7, no. 12. (December 2012.): e51351-.

Bolton M, Horvath DJ, Li B, Cortado H, Newsom D, White P, Partida-Sanchez S, JusticeSS. "Intrauterine growth restriction is a direct consequence of localized maternal eropathogenic Escherichia coli cystitis." PloS One. Vol. 7, no. 3. (March 2012.): e33897-.

Beceiro S, Cortado H, Partida-Sanchez S. "Novel CX3CR1+hi monocyte-derived dendritic cell subtype with inflammatory properties." Journal of Immunology. Vol. 190, (May 2013.): 115-18.

Partida-Sanchez S, Cortado H, Horvath D, Li R, Flano E, Justice S. "Nonclassical monocyte-derived macrophages are essential for preventing pyelonephritis upon urinary tract infection in mice." Journal of Immunology. Vol. 190, (May 2013.): 130-4.

Becknell B, Eichler T, Beceiro S, Li B, Easterling R, Carpenter A, Partida-Sánchez S, Spencer JD. "Ribonucleases 6 and 7 have anitmicrobial function in the human and murine urinary tract." Kidney International. Vol. 87, no. 1. (July 2014.): 151-61.

Petrovic-Djergovic D, Popovic M, Chittiprol S, Cortado H, Ransom RF, Partida-Sánchez S. "CXCL10 induces the recruitment of monocyte derived macrophages into kidney, which aggravate puromycin aminonucleoside nephrosis." Clinical & Experimental Immunology. Vol. 180, no. 2. (May 2015.): 305-15.

Tara S, Kurobe H, de Dios Ruiz Rosado J, Best CA, Shoji T, Mahler N, Yi T, Lee YU, Sugiura T, Hibino N, Partida-Sanchez S, Breuer CK, Shinoka T. "Cilostazol, not asprin, prevents stenosis of bioresorbable vascular grafts in a venous model." Thromb Vasc Biol. Vol. 35, no. 9. (September 2015.): 2003-2010.

Jablonski KA, Amici SA, Webb LM, Ruiz-Rosado Jde D, Popovich PG, Partida-Sanchez, S, Guerau-de-Arellano M. "Novel markers to delineate murine M1 and M2 macrophages." PLoS One. Vol. 10, no. 12. (December 2015.): e0145342-.

 

Inventions and Patents

Lund, Frances E, Randall, Troy D, and Partida-Sanchez, Santiago. Inventor. "Methods for Identifying compounds that inhibit CD38 activity." U.S Patent office. Issued 2005,

Frances E. Lund, Troy D. Randall, and Santiago Partida-Sanchez. Inventor. "SM38 NUCLEIC ACID MOLECULES." Issued 2010,

Lund, Frances E., Partida-Sanchez, Santiago, Walseth, Tim. Inventor. "TRPM2-Specific Inhibitors." filed 2007,

Partida-Sanchez, Santiago, Robert Peterson. "Tissue Disaggregator." filed 2010,

Lund, Frances E, Randall, Troy D, Partida-Sanchez, Santiago. Inventor. "CD38 Modulated Chemotaxis." Issued 2008,

 

Presentations

"Tumor Necrosis Factor (TNF) in leprosy patients with type II reaction." Presented at The 14th Annual International Leprosy Congress, Orlando, FL, US|USA. (August 1993)

"Changes in morphology and motility induced by monoclonal antibodies against some lymphocyte surface antigensin activated B, but not T cells." Presented at The 4th Latin American Congress of Immunology, Zacatecas. (March 1996)

"Ligation of Murine CD38 in early B lineage cells induces homotypic aggregation." Presented at FASEB Summer Conference, Saxtons River, VT. (July 1998)

"A new emergent role for CD38 during innate immune responses." Presented at FASEB AAi-Immunology Meeting, Seattle, WA. (May 2000)

"Production of cADPR by CD38 controls capacitative calcium influx and neutrophil chemotaxis to bacterial chemoattractants and is required for bacterial clearance." Presented at The 11th International Congress of Immunology, Stockholm. (July 2001)

"CD38 catalyzed cADPR controls neutrophil chemotaxis, calcium influx and bacterial clearance." Presented at FASEB Experimental Biology Meeting, Orlando, FL. (March 2001)

"CD38 regulates immune responses by modulating T cell priming by antigen-presenting cells." Presented at FASEB Experimental Biology Meeting, New Orleans, LA. (April 2002)

"regulation of phagocytic cell trafficking by the ADP-ribosyl cyclase DC38: Impact on inflammation disease, and immunity." Presented at Special Seminar, Vertex Pharmaceuticals, San Diego, CA. (December 2003)

"Novel role for CD38 in regulating inflammation, immunity and disease." Presented at Special Seminar, Lexicon Genetics, Inc, The Woodlands, TX. (July 2004)

"Regulation of dendritic cell trafficking by the ADP-Ribosyl cyclase CD38: impact on the development of humoral immunity." Presented at The 12th International Congress of Immunology, Montreal. (July 2004)

"The ectoenzyme CD38 controls GPCR signaling: in search of a new way to modulate inflammation, immunity and disease." Presented at Special Seminar, Bristol-Myers Squibb Company, Syracuse, NY. (April 2004)

"Regulation of innate and adaptive immune responses by the ADp-ribosyl cyclase DC38." Presented at Immunology Seminar Series, Department of Immunology, Cleveland, OH. (April 2004)

"Regulation of phagocytic cell trafficking by the ADP-ribosyl-cyclasa CD38, Impact on inflammationdisease and immunity." Presented at The Research Institute Seminar Series, Department of Microbial Pathogenesis, Columbus, OH. (May 2004)

"Role for cADPR during chemokine receptor initiated signal transduction and chemotaxis of phagocytic." Presented at Microbiology and Immunology Seminar Series, Department Microbiology and Molecular Genetics, Medical College of Wisconsin, Milwaukee, WI. (June 2004)

"Regulation of phagocyte chemotaxis and migration; role for cADPR and ADPR, novel calcium second messengers." Presented at Center for Microbial Interface Biology, The Ohio State University, Columbus, OH. (April 2005)

"Regulation of cell trafficking under homeostasis and inflammatory conditions: Roles for CD38, cADPR and Gaq." Presented at Keystone Symposia: Chemokines and Chemokine Receptors, Snowbird, UT. (January 2006)

"Expression and function of TRPM2 cation channels in immune cells." Presented at Department Seminar Series Center for Molecular Biomedicine, national Polytechnic Institute, Mexico City. (August 2007)

"The role of NAD+ metabolites regulationg immune cell migration." Presented at The Research Institute at Nationwide Childrens Hospital Annual Retreat 2007, Columbus, OH. (April 2007)

"Regualtions of oxidative-stress-induced phagocyte cell death by NAD+ metabolites." Presented at Special Seminar Series Center for Perinatal Research, The Research Institute at Nationwide Children's Hospital, Columbus, OH. (June 2007)

"Regulation of phagocyte cell migrationby NAD+ metabolites." Presented at Immunology Seminar Program, Department of Pathology, Columbus, OH. (February 2007)

"Reactive oxygen species induce calcium influx and phagocyte cell death by a mechanism dependent on ADPR and PARP-1; Possible functional role for TRPM2 cation channel." Presented at Keystone Symposia, Breckenridge, CO. (September 2007)

"Function of TRPM2 cation channels in dendtritic cells." Presented at Immunology Seminar Series, Depatment of Patholgy, New York University, New York, NY. (December 2008)

"TRP channels in phagocytes: novel senors of tissue damage and cellular stress." Presented at Research Seminar Series, Center for Microbial Interface Biology, The Ohio State University, Columbus, OH. (April 2008)

"Integration of Ca2+ signals by TRP channels during dendritic cell responses to danger." Presented at Second center for Microbial Interface Biology Research Retreat, Columbus, OH. (September 2008)

"NAD+ derived nucleotides active calcium signaling via TRPM2 channels in immune cells." Presented at Research Seminar Series, Department of Medicinal and Biological Chemistry, Toledo, OH. (December 2009)

"Maternal UTI-Mediated Preterm Birth: A Mouse Model.." Presented at Center for Microbial Interface Biology Research Retreat., Columbus, OH, US|USA. (March 2010)

"Maternal UTI-Mediated Preterm Birth: A Mouse Model.." Presented at The Research Institute at Nationwide Children's Hospital Research Week, Columbus, OH, US|USA. (April 2010)

"Intracellular high- calcium micro-domains in Dendritic cells their possible role in chemotaxis." Presented at Immunology Seminar Program, Columbus, OH, US|USA. (January 2010)

"Novel calcium release mechansim is essential for chemotaxis of dendritic cells." Presented at Research Seminar Series, Columbus, OH, US|USA. (February 2010)

"A Novel Mouse Model Investigating Maternal UTI-Mediated Preterm Birth.." Presented at The 48th Annual Meeting of the Infectious Diseases Society of America, British Columbia. (October 2010)

"Novel calcium release mechanism is essential for chemotaxis of dendritic cells." Presented at Research Seminar Series, Center for Microbial Interface Biology, The Ohio State University, Columbus, OH. (February 2010)

"TRPM2 is a novel Calcium Release Channel essential for Chemotaxis of Dendritic Cells." Presented at The Research Institute at Nationwide Children's Hosptial Research Week, Columbus, OH, US|USA. (April 2010)

"Azole derivative drugs inhibit neutrophil chemotaxis by blocking the Calcium permeant channel TRPM2." Presented at IMMUNOLOGY 2010â„¢, 97th Annual Meeting of The American Association of Immunologists, Baltimore, MD, US|USA. (May 2010)

"Transient Receptor Potential Melastatin 2 (TRPM2) is a Calcium Release Channel Essential for Chemotaxis of Dendritic Cells.." Presented at IMMUNOLOGY 2010â„¢, 97th Annual Meeting of The American Association of Immunologists, Baltimore, MD, US|USA. (May 2010)

"Transient Receptor Potential Melastatin 2 (TRPM2) is a Calcium Release Channel Essential for Chemotaxis of Dendritic Cells.." Presented at 14th International Congress of Immunology, Kobe, Japan. (August 2010)

"Intracelluar high-calcium micro-domains in Dendritic cells their possible role in chemotaxis." Presented at Immunology Seminar Program, Department of Pathology, Columbus, OH. (January 2010)

"Resident macrophages are required for control of urinary tract infection in mice.." Presented at The Ohio State University Medical College Research Day, Columbus, OH, US|USA. (April 2011)

"Resident macrophages are required for control of urinary tract infection in mice.." Presented at Ohio Branch of the American Society for Microbiology, Athens, OH, US|USA. (April 2011)

"Resident macrophages are required for control of urinary tract infection in mice.." Presented at Research Week at The Research Institute at Nationwide Children’s Hospital, Columbus, OH, US|USA. (April 2011)

"Resident macrophages are required for control of urinary tract infection in mice.." Presented at The Ohio Branch of the American Society for Microbiology, Athens, OH, US|USA. (April 2011)

 

Professional Activities

2007 - present Center for Microbial Interface Biology First Research Annual Retreat, Organizer and Judge. The Ohio State University Center for Microbial Interface Biology. Columbus, OH.
2008 - present Center for Microbial Interface Biology First Research Annual Retreat, Judge. The Ohio State University, Center for Microbial Interface Biology. Columbus, OH.
2009 - present Panel reviewer Breast Cancer Immunological Sciences (BC09) for Department of Defense (DoD) Congressionally Directed Medical Research Programs (CDMRP).
2010 - present US Army Medical Research and Material Command (USAMRMC) and The Scientific Peer Advisory and Review Services division of the American Intisutute of Biological Sciences (AIBS).
2004 External Consultant Scientist. ChemoCentryx, Inc. Mountain View, CA.
2005 - 2009 OSUMC Graduate and Postgraduate Research Day Judge. The Ohio State University. Columbus, OH.
 

Unpublished Works

Cortado H, Horvath Jr. DJ, Beceiro S, Li B, Justice SS and Partida-Sánchez S.. Isolation and flow cytometric assessment of macrophages from urinary tract organs upon UPEC infection.. January 0.

Lang I, Sumoza-Toledo A, Bhagat H, Beceiro S, Cortado H, and Partida-Sánchez S. Azole derivative drugs inhibit neutrophil chemotaxis by blocking the Calcium permeant channel TRPM2. January 0.

Beceiro S, A-Gonzalez N, Deniz J, Gallardo G, Dominguez PM, Corbi A, Ardavin C, Partida-Sánchez S, Rodriguez-Fernandez JL, and Castrillo A. Regulation of Dendritic Cell migration by endogenous Liver X Receptor Signaling. January 0.

Partida-Sánchez S, Beceiro S, Koomoa-Lange D, Koomoa-Lange I. Calcium: signals and channels that underlie chemotactic migration of phagocytes. January 0.

Robledo-Avila F, Koop B, Amer A, and Partida-Sánchez S. Cystic fibrosis neutrophils are defective in the axis ROS-NETs and cannot control Burkholderia cenocepacia infection. January 0.

Tara S, Kurobe H, Ruiz-Rosado JD, Best CA, Shoji T, Mahler N, Yi T, Lee YU, Sugiura T, Hibina N, Partida-Sanchez S, Breuer CK, Shinoka T. Cilostazol, not aspirin, prevents stenosis of tieeus engineered vascular grafts accompanied by reduction of smooth muscle cell proliferation and acute inflammation. January 2015.

Lee YU, Ruiz-Rosada JD, Mahler N, Best CA, Tara S, Yi T, Shoji T, Suiguira T, Lee AY, Hibino N, Shinoka T, Partida-Sanhez S, Breuer CK. TGF-beta-R1 inhibition causes improved tissue engineered vascular graft patency via regulating activation of infiltrating mononcytes. January 2015.

Cortado H, Horvath Jr DJ, Beceiro S, Li B, Flano E, Justice SS and Partida-Sanchez S. Monocyte-derived inflammatory dendritic cells expressing CS3CR1-hi control urinary tract infection in mice. April 2015.

Beceiro S, Radin JN, Chatuvedi R, Piazuelo B, Horvath Jr. DJ, Cortado H, Dixon B, Gu C, Wilson KT, Koomoa-Lange I, Kooma-Lange D, Scott-Algood HM and Partida-Sanchez S. TPRM2 ion channels regulate NADPH oxidase activity and macrophage polarization upon Helicobacter pylori infection. February 2015.