Renukaradhya Gourapura, PhD

Current OSU Appointment

Assistant Professor, OARDC Food Animal Health

Advising Narrative

Standardized an immunological assay to detect arginase present in pig immune cells, to understand the immune evasion strategies of porcine reproductive and respiratory syndrome virus in pigs.

Noteworthy Graduate Narrative

1. Binjawadagi B (graduate student): First place for the Best Oral Presentation and Young Investigator Award (AAVI-Immunology Section). Nanoparticle-based adjuvanted inactivated porcine reproductive and respiratory syndrome virus vaccine elicits cross-protective immunity in pigs. 93rd Annual Meeting of the Conference of Research Workers in Animal Diseases, December 2-4, 2012. Chicago, IL. Abstract 122.

Chapters in Books

Hodgins DC, Chattha K, Vlasova A, Parreno V, Corbeil LB, Renukaradhya GJ, and Saif LF. "Porcine reproductive and respiratory syndrome." In Mucosal Veterinary Vaccines: Comparative Vaccinology. Edited by Hodgins DC. -. January 0.

Shaila, MS, Renukaradhya, GJ.. "Host Immune Responses Against Peste des Petits Ruminants Virus." In Peste des Petits Ruminants Virus. Edited by Muhammad Munir. -. January 0.

Liu J; Renukaradhya GJ; Brutkiewicz RR. "The regulation of CD1d+ and CD1d- tumors by NKT cells. Balancing the Regulation of Tumor Immunity." In Balancing the Regulation of Tumor Immunity. Edited by Terabe M and Berzofsky JA. 71-94. New York, NY, US|USA: Springer Science+Business Media, LLC, January 2011.

Journal Articles

Renukaradhya, G.J.*, S. Isloor and M. Rajasekhar. "Epidemiology, zoonotic aspects, vaccination and control / eradication of brucellosis in India." Veterinary Microbiology. Vol. 90, no. 1-4. (December 2002.): 183-195.

Jung K; Gurnani A; Renukaradhya GJ; Saif LJ. "Nitric oxide is elicited and inhibits viral replication in pigs infected with porcine respiratory coronavirus but not porcine reproductive and respiratory syndrome virus." Vet. Immunol. Immunopath. Vol. 136, (January 2010.): 335-339.

Renukaradhya GJ*; Alekseev KP; Jung K; Fang Y; Saif LJ. "Porcine reproductive and respiratory syndrome virus induced immunosuppression exacerbate the inflammatory response to porcine respiratory coronavirus in pigs." Viral Immunol. Vol. 23 *Corresponding author, no. 5. (October 2010.): 457-466.

Khatri M; Dwivedi V; Krakowka S; Manickam C; Ali A; Wang L; Qin Z; Renukaradhya GJ*; Lee CW*. "Swine influenza virus induces acute inflammatory immune responses in pig lungs: a potential animal model to understand human pandemic H1N1 influenza virus." J. Virol.. Vol. 84 *Corresponding authors, no. 21. (November 2010.): 11210-11218.

Yassine KM; Lee CW; Renukaradhya GJ; Saif YM. "Interspecies and intraspecies transmission of influenza A viruses: viral, host and environmental factors." Animal Health Research Reviews. Vol. 11, no. 1. (June 2010.): 53-72.

Renukaradhya GJ*; Manickam C; Khatri M; Rauf A; Li X; Tsuji M; Rajashekara G; Dwivedi V. "Functional Invariant NKT Cells in Pig Lungs Regulatethe Airway Hyperreactivity: A Potential Animal Model." J Clin Immunol. Vol. 2, no. 31. (January 2011.): 228-239.

Khandelwal A; Renukaradhya GJ; Rajasekhar M; Lakshmi Sita G; Shaila MS. "Immune responses to Hemagglutinin-Neuraminidase protein of peste des petits ruminants virus expressed in transgenic peanut plants in sheep." Vet. Immunol. Immunopath.. Vol. 3-4, no. 140. (January 2011.): 291-296.

Binjawadagi B, V. Dwivedi, C. Manickam, J.B. Torrelles, and G.J. Renukaradhya. "Intranasal delivery of an adjuvanted modified live porcine reproductive and respiratory syndrome virus vaccine reduces the ROS production." Viral Immunology. Vol. 6, no. 24. (January 2011.): 475-482.

Dwivedi. V; C. Manickam; R. Patterson; K. Dodson; M. Weeman; and G.J. Renukaradhya. "Intranasal delivery of whole cell lysate of Mycobacterium tuberculosis induces protective immune responses to a modified live porcine reproductive and respiratory syndrome virus vaccine in pigs." Vaccine. Vol. 23, no. 29. (January 2011.): 4067-4076.

Dwivedi. V; C. Manickam; R. Patterson; K. Dodson; M. Murtaugh; J.B. Torrelles; L.S. Schlesinger; G.J. Renukaradhya. "Cross-protective immunity to porcine reproductive and respiratory syndrome virus by intranasal delivery of a live virus vaccine with a potent adjuvant." Vaccine. Vol. 23, no. 29. (January 2011.): 4058-4066.

Dwivedi V; Manickam C; Binjawadagi B; Patterson R: Linhares D; Murtaugh MP; Renukaradhya GJ. "Evaluation of immune responses to porcine reproductive and respiratory syndrome virus in pigs during early stage of infection." Virology Journal. Vol. 45, no. 9. (February 2012.): 1-7.

Renukaradhya, GJ, Dwivedi, V, Manickam, C, Binjawadagi, B, Benfield, D.. "Mucosal vaccines to control porcine reproductive and respiratory syndrome: a new perspective." Animal Health Research Review, June 2012. Vol. 1, (May 2012.): 21-37.

Broxmeyer, HE, Christopherson, K, Hangoc, G, Cooper, S, Mantel, C, Renukaradhya, GJ, and Brutkiewicz, RR.. "CD1d Expression on and regulation of murine hematopoietic stem and progenitor cells." Blood 2012 Apr 25.. Vol. 119, no. 24. (April 2012.): 5731-5741.

Manickam C, V. Dwivedi, R. Patterson, K. Dodson and G.J. Renukaradhya. "Differential regulation of mucosal immune responses at various mucosal tissues in pigs infected with VR2332 strain of PRRSV." Veterinary Microbiology. Vol. 162, (December 2012.): 68-77.

Dwivedi V, C. Manickam, B. Binjawadagi, Joyappa, D, and G.J. Renukaradhya. "Biodegradable nanoparticle-entrapped vaccine induces cross-protective immune response against a virulent heterologous respiratory viral infection in pigs." PLOS One. Vol. 7, no. 12. (December 2012.): e51794-.

Manickam C, V. Dwivedi, J. Miller, T. Papenfuss and G.J. Renukaradhya. "Mycobacterium tuberculosis whole cell lysate enhances proliferation of CD8 positive lymphocytes and nitric oxide secretion in the lungs of live porcine respiratory and reproductive syndrome virus vaccinated pigs." Viral Immunol.. Vol. 26, no. 1. (January 2013.): 102-108.

Renukaradhya, GJ,. "Adjuvant Improves Response of PRRS Vaccine." Swine Research Review. -.

Reference Works

December 2009	Dwivedi, V., C. Manickam, R. Patterson, K. Dodson, and G. J. Renukaradhya."Steps towards development of a novel mucosal vaccine to PRRSV" . : 84
December 2009	Dwivedi, V., C. Manickam, R. Patterson, K. Dodson, and G. J. Renukaradhya."Steps towards development of a novel mucosal vaccine to PRRSV" . : 110
December 2010	Dwivedi, V; C. Manickam; B. Binjawadagi; R. Patterson; K. Dodson; and G. J. Renukaradhya."Mucosal immunization with biodegradable PLG- nanoparticles elicits effective anti-PRRSV immune responses in Pigs" Chicago. : 66
December 2010	Dwivedi, V; C. Manickam; B. Binjawadagi; R. Patterson; K. Dodson; and G. J. Renukaradhya."Mucosal immunization with biodegradable PLG- nanoparticles elicits effective anti-PRRSV immune responses in Pigs" Chicago. : No. 129
May 2010	G.J. Renukaradhya; C. Manickam; V. Dwivedi."Invariant NKT cells in pig lung: a potential asthma model" Baltimore. : 271
August 2010	Dwivedi V; C. Manickam; R. Patterson; K. Dodson; M. Murtaugh; J. Torrelles; L. Schlesinger; and G.J. Renukaradhya."Mucosal vaccine to protect against porcine reproductive and respiratory syndrome: a new perspective" Tokyo. : 84
November 2010	Dwivedi, V; C. Manickam; B. Binjawadagi; R. Patterson; K. Dodson; and G. J. Renukaradhya."Mucosal immunization with biodegradable PLG- nanoparticles elicits effective anti-PRRSV immune responses in Pigs" Columbus.
November 2010	Dwivedi, V., C. Manickam, B. Binjawadagi, R. Patterson, K. Dodson, and G. J. Renukaradhya."Mucosal immunization with biodegradable PLG- nanoparticles elicits effective anti-PRRSV immune responses in Pigs" Columbus.
December 2010	Manickam, C; V. Dwivedi; M. Khatri; R. Patterson; T. Papenfus; and G. J. Renukaradhya."Mucosal adjuvanticity of M.tb whole cell lysate to PRRSV live vaccine leads to a better immunostimulation and protection against PRRSV challenge" Chicago. : 9
December 2010	Manickam, C; V. Dwivedi; M. Khatri; R. Patterson; T. Papenfus; and G. J. Renukaradhya."Mucosal adjuvanticity of M.tb whole cell lysate to PRRSV live vaccine leads to a better immunostimulation and protection against PRRSV challenge" Chicago. : No. 133
December 2011	Binjawadagi, B., V. Dwivedi, C. Manickam, J. B. Torrelles, and G. J. Renukaradhya."Intranasal delivery of an adjuvanted modified live porcine reproductive and respiratory syndrome virus vaccine reduces the ROS induced lung pathology" Chicago. : 43
December 2011	Binjawadagi, B., V. Dwivedi, C. Manickam, J. B. Torrelles, and G. J. Renukaradhya."Intranasal delivery of an adjuvanted modified live porcine reproductive and respiratory syndrome virus vaccine reduces the ROS induced lung pathology" Chicago. : No. 178
May 2011	Dwivedi, V., C. Manickam, B. Binjawadagi, M. Khatri, R. Patterson, and G. J. Renukaradhya.."Mucosal immunization with biodegradable PLG- nanoparticles elicits effective anti-PRRSV immune responses in Pigs" SanFranscico. : 305
December 2011	Manickam, C., V. Dwivedi, R. Patterson, T. Papenfuss, and G. J. Renukaradhya."Differential regulation of mucosal immune responses at various mucosal tissues in pigs infected with PRRSV strain VR2332" Chicago. : 52
December 2011	Manickam, C., V. Dwivedi, R. Patterson, T. Papenfuss, and G. J. Renukaradhya."Differential regulation of mucosal immune responses at various mucosal tissues in pigs infected with PRRSV strain VR2332" Chicago. : No.117
December 2011	Dwivedi, V., C. Manickam, B. Binjawadagi, R. Patterson, and G. J. Renukaradhya."Nanoparticles entrapped killed PRRSV vaccine reduces PRRSV viremia in both homologous and heterologous PRRSV challenged pigs" Chicago. : 58
December 2011	Dwivedi, V., C. Manickam, B. Binjawadagi, R. Patterson, and G. J. Renukaradhya."Nanoparticles entrapped killed PRRSV vaccine reduces PRRSV viremia in both homologous and heterologous PRRSV challenged pigs" Chicago. : No. 120
December 2011	Dwivedi, V., C. Manickam, B. Binjawadagi, D. Linhares, M. P. Murtaugh, and G. J. Renukaradhya."Evaluation of immune responses to porcine reproductive and respiratory syndrome virus in pigs at day two post-infection" Chicago. : 81
December 2011	Dwivedi, V., C. Manickam, B. Binjawadagi, D. Linhares, M. P. Murtaugh, and G. J. Renukaradhya."Evaluation of immune responses to porcine reproductive and respiratory syndrome virus in pigs at day two post-infection" Chicago. : No. 141
April 2012	Manickam, C, Dwivedi, V, Patterson, R, Dodson, K, Papenfuss, T, Renukaradhya, GJ."PRRSV Pathogenesis" Wooster.
April 2012	Manickam, C, Dwivedi, V, Patterson, R, Dodson, K, Papenfuss, T, Renukaradhya, GJ."PRRSV Pathogenesis" Columbus.
December 2012	Binjawadagi B, V. Dwivedi, C. Manickam, K. Ouyang, J.B. Torrelles, and G. J. Renukaradhya."Immnology Section" Chicago.
April 2012	Dwivedi, V, Manickam, C, Renukaradhya, GJ,."Influenza pathogenesis" Columbus.
April 2012	Binjawadagi, B, Dwivedi, V, Manickam, C, Ouyang, K, Torrelles, JB, Renukaradhya, GJ."PRRSV vaccine" Wooster.
April 2012	Binjawadagi, B, Dwivedi, V, Manickam, C, Ouyang, K, Torrelles, JB, Renukaradhya, GJ."PRRSV vaccine" Columbus.
May 2012	Dwivedi, V, Manickam, C, Renukaradhya, GJ,."Influenza pathogenesis" Columbus.
July 2012	Binjawadagi, B, Dwivedi, V, Manickam, C, Torrelles, JB, Renukaradhya, GJ."PRRSV vaccine" Cairns.
November 2012	Ouyang K, B. Binjawadagi, N. Elkalifa, J. Wu, C. Olsen J.B. Torrelles, J. Zimmerman, and G. J. Renukaradhya."PRRS symposium" Kansas City.
November 2012	Olsen, C, Karriker L, Wang C, Abate S, Binjawadagi B, Christopher-Hennings J, Doolittle K, Harmon K., A. Kittawornrat, A. Kurtz, E. Kurtz, S. Lizano, J. Coetzee, R. Main, A. Meiszberg, E. Nelson, T. Otterson, Y. Panyasing, C. Rademacher, R. Rauh, G.J. Renukaradhya, R. Shah, J. Zimmerman."Diagnostics" Ames.
November 2012	Binjawadagi B, V. Dwivedi, C. Manickam, K. Ouyang, J.B. Torrelles, and G. J. Renukaradhya."PRRS symposium" Kansas City.
December 2012	Ouyang K, B. Binjawadagi, N. Elkalifa, J. Wu, C. Olsen J.B. Torrelles, J. Zimmerman, and G. J. Renukaradhya."Respiratory diseases" Chicago.
December 2012	Olsen C, L. Karriker, C, Wang, S. Abate, B. Binjawadagi, J. Christopher-Hennings, K. Doolittle, K. Harmon, A. Kittawornrat, A. Kurtz, E. Kurtz, S. Lizano, J. Coetzee, R. Main, A. Meiszberg, E. Nelson, T. Otterson, Y. Panyasing, C. Rademacher, R. Rauh, G.J. Renukaradhya, R. Shah, J. Zimmerman."Diagnostics" Chicago.
December 2012	Manickam C, K. Ouyang, B. Binjawadagi, K. Henn, P. Crittenden, J. Hiremath, M. Khatri and G. J. Renukaradhya."Respiratory diseases" Chicago.

Inventions and Patents

Renukaradhya, GJ, Binjawadagi, B, Kang, O, Zimmerman, JJ,. "Development and Validation of Pig Oral Fluid Based Diagnostic Tool to Determine the Herd Immunity." Filed November 2012.

Presentations

"Evaluation of adjuvants at the mucosal area for the development of innovative mucosal vaccine against PRRS." Presented at the USDA NPB meeting, Des Moines, IA, US|USA. (June 2009)

"Alternative models for study of respiratory diseases: Pig is a useful animal model to address both infectious and non-infectious lung diseases." Presented at Immunologists Round Table meeting, Columbus, OH, US|USA. (November 2010)

"Mucosal immunization with biodegradable PLG- nanoparticles elicits effective anti-PRRSV immune responses in Pigs." Presented at Fourth International Scholar Research Exposition, The Ohio State University, Columbus, OH, US|USA. (November 2010)

"A non-radioactive colorimetric assay to detect Natural Killer cell-mediated cytotoxicity." Presented at Immunologists Round Table Meeting, Wooster, OH, US|USA. (February 2010)

"Development of novel mucosal vaccines for the control of PRRS outbreaks.." Presented at the USDA NPB meeting, Des Moines, IA, US|USA. (June 2010)

"Mucosal vaccine to protect against porcine reproductive and respiratory syndrome: a new perspective." Presented at the 9th International Veterinary Immunology Society (IVIS) meeting, Tokyo, JP|JPN. (August 2010)

"Mucosal vaccine to protect against porcine reproductive and respiratory syndrome: a new perspective." Presented at Association of Microbiologists, Bangalore, Karnataka, IN|IND. (August 2010)

"Mucosal immunization with biodegradable PLG- nanoparticles elicits effective anti-PRRSV immune responses in Pigs." Presented at CRWAD Meeting, Chicago, IL, US|USA. (December 2010)

"Mucosal immunization with biodegradable PLG- nanoparticles elicits effective anti-PRRSV immune responses in Pigs." Presented at International PRRS Symposium 2010, Chicago, IL, US|USA. (December 2010)

"Invariant NKT cells in pig lung: a potential asthma model." Presented at 97th Annual Meeting, American Association of Immunologists, Immunology 2010, Baltimore, MD, US|USA. (May 2010)

"Mucosal adjuvanticity of M.tb whole cell lysate to PRRSV live vaccine leads to a better immunostimulation and protection against PRRSV challenge." Presented at International PRRS Symposium 2010, Chicago, IL, US|USA. (December 2010)

"Mucosal adjuvanticity of M.tb whole cell lysate to PRRSV live vaccine leads to a better immunostimulation and protection against PRRSV challenge." Presented at CRWAD Meeting, Chicago, IL, US|USA. (December 2010)

"Development of novel mucosal vaccines for the control of viral diseases in a pig model." Presented at Immunology Seminar Program, Pathology 850 Course, Columbus, OH, US|USA. (January 2011)

"Invariant NKT cells in pig lung: a potential asthma model." Presented at Center for Clinical and Translational Sciences, 2nd annual meeting, The Ohio State University, Columbus, OH, US|USA. (May 2011)

"Invariant NKT cells in pig lung: a potential asthma model." Presented at Center for Clinical and Translational Sciences, 2nd annual meeting, Columbus, OH, US|USA. (May 2011)

"Mucosal immunization with biodegradable PLG- nanoparticles elicits effective anti-PRRSV immune responses in Pigs." Presented at 98th Annual Meeting, The American Association of Immunologists, SanFrancisco, CA, US|USA. (May 2011)

"Nanoparticles entrapped killed PRRSV vaccine reduces PRRSV viremia in both homologous and heterologous PRRSV challenged pigs." Presented at Conference Research Workers in Animal Diseases, Annual Meeting, Chicago, IL, US|USA. (December 2011)

"Nanoparticles entrapped killed PRRSV vaccine reduces PRRSV viremia in both homologous and heterologous PRRSV challenged pigs." Presented at International PRRS Symposium 2011, Chicago, IL, US|USA. (December 2011)

"Evaluation of immune responses to porcine reproductive and respiratory syndrome virus in pigs at day two post-infection." Presented at International PRRS Symposium 2011, Chicago, IL, US|USA. (December 2011)

"Evaluation of immune responses to porcine reproductive and respiratory syndrome virus in pigs at day two post-infection." Presented at Conference Research Workers in Animal Diseases, Annual Meeting, Chicago, IL, US|USA. (December 2011)

"Intranasal delivery of an adjuvanted modified live porcine reproductive and respiratory syndrome virus vaccine reduces the ROS induced lung pathology." Presented at Conference Research Workers in Animal Diseases, Annual Meeting, Chicago, IL, US|USA. (December 2011)

"Intranasal delivery of an adjuvanted modified live porcine reproductive and respiratory syndrome virus vaccine reduces the ROS induced lung pathology." Presented at International PRRS Symposium 2011, Chicago, IL, US|USA. (December 2011)

"Differential regulation of mucosal immune responses at various mucosal tissues in pigs infected with PRRSV strain VR2332." Presented at Conference Research Workers in Animal Diseases, Annual Meeting, Chicago, IL, US|USA. (December 2011)

"Differential regulation of mucosal immune responses at various mucosal tissues in pigs infected with PRRSV strain VR2332." Presented at International PRRS Symposium 2011, Chicago, IL, US|USA. (December 2011)

"World Veterinarians Day 2012; Significance and Importance." Presented at World Veterinarians Day 2012, Hospet, Karnataka, IN|IND. (April 2012)

"Development of croos-protective mucosal vaccines to control infectious respiratory viral diseases in a pig model." Presented at IAH&VB meeting, Bengaluru, Karnataka, IN|IND. (April 2012)

"Suppression of CD8+ T cells function in pigs infected with swine influenza viruses." Presented at PHPID Annual Member Meeting, Columbus, OH, US|USA. (April 2012)

"Development of mucosal vaccines in pigs against porcine reproductive and respiratory syndrome." Presented at 6th International Veterinary Vaccines and Diagnostics Conference, Cairns, Queensland, AU|AUS. (July 2012)

"Immune modulation at mucosal sites of pigs infected with a vaccine strain of PRRS virus." Presented at PHPID Annual Member Meeting, Columbus, OH, US|USA. (April 2012)

"Immune modulation at mucosal sites of pigs infected with a vaccine strain of PRRS virus." Presented at OARDC Annual Research Conference, Wooster, OH, US|USA. (April 2012)

"Nanoparticle-based killed adjuvanted porcine reproductive and respiratory syndrome virus vaccine elicits superior cross-protective immunity in pigs." Presented at PHPID Annual Member Meeting, Columbus, OH, US|USA. (April 2012)

"Nanoparticle-based killed adjuvanted porcine reproductive and respiratory syndrome virus vaccine elicits superior cross-protective immunity in pigs." Presented at OARDC Annual Research Conference, Wooster, OH, US|USA. (April 2012)

"Suppression of CD8+ T cells function in pigs infected with swine influenza viruses." Presented at Center for Clinical and Translational Sciences, 3rd annual meeting, Columbus, OH, US|USA. (May 2012)

Unpublished Works

Dwivedi, V, Manickam, C, Patterson, R, Binjawadagi, B, Renukaradhya, GJ. PLGA nanoparticle entrapped killed porcine reproductive and respiratory syndrome virus vaccine helps in viral clearance in pigs. February 2013.

Binjawadagi B, V. Dwivedi, C. Manickam, J. Torrelles, and G.J. Renukaradhya. Nanoparticle-based adjuvanted inactivated porcine reproductive and respiratory syndrome virus vaccine elicits superior cross-protective immunity in pigs. February 2013.