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Renukaradhya Gourapura, PhD


Staff photo

1680 Madison Ave
Wooster, OH 44691

Phone: (330) 263-3748

Email: gourapura.1@osu.edu

 

Current OSU Appointment

Associate Professor, OARDC Food Animal Health

 

Advising Narrative

Undergraduate students of College of Wooster (Thesis and Research Co-Advisor)



1. Kara Henn (2012 - 2013). Title of the thesis - "Development of novel mucosal vaccines against swine influenza virus in pigs."



2. Brittany L. Lynch (2013 - 2014). Title of the thesis - "Evaluation of humoral immune response in pigs vaccinated with nanoparticle-entrapped PRRS virus vaccine."



3. John Michael Thompson (2013 - 2014). Title of the thesis - Evaluation of antibody response in pigs to PRRS virus vaccine."





Undergraduate students: publications and presentations



1. Matthew Weeman

Dwivedi. V; C. Manickam; R. Patterson; K. Dodson; M. Weeman; and G.J. Renukaradhya, "Intranasal delivery of whole

cell lysate of Mycobacterium tuberculosis induces protective immune responses to a modified live porcine reproductive

and respiratory syndrome virus vaccine in pigs". Vaccine. Vol. 23, no. 29: 4067-4076. 2011. (Published)



2. Matthew Weeman (2009). OARDC Summer Research Internship Program, The Ohio State University, Oral presentation, "Study of mucosal immune response in the respiratory tract of pigs infected with porcine reproductive and respiratory syndrome." Fisher Auditorium, OARDC, Wooster, August 2009.



3. Jayla Miller

Manickam C, V. Dwivedi, J. Miller, T. Papenfuss and G.J. Renukaradhya, "Mycobacterium tuberculosis whole cell

lysate enhances proliferation of CD8 positive lymphocytes and nitric oxide secretion in the lungs of live porcine

respiratory and reproductive syndrome virus vaccinated pigs". Viral Immunol.. Vol. 26, no. 1: 102-108. 2013.

(Published)



4. Samyra Martin (2010), a Minority Internship Undergraduate Student, Summer Research Opportunities Program (SROP), The Ohio State University, presented a poster - "The Characterization of Myeloid Derived Suppressor Cells." Annual SROP Research Symposium, Columbus, September 2010.



5. Sha’Rayna Oree (2011), a Minority Internship Undergraduate Student, Summer Research Opportunities Program (SROP), The Ohio State University, presented a poster - "NKT cell specific adjuvant potentiates mucosal immunity to killed swine Influenza virus vaccine." Annual SROP Research Symposium, Columbus, July 2011.



6. Nadia Elkalifa (2012), a Minority Internship Undergraduate Student, Summer Research Opportunities Program (SROP), The Ohio State University, presented a poster - "Comparison of Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) Neutralizing Antibody Titers in Oral Fluid and Serum." Annual SROP Research Symposium, Columbus, August 2012.



7. Lanre Odusote (2013), a Minority Internship Undergraduate Student, SROP, The Ohio State University, presented a poster - "Use of Hematoxylin and Eosin (H&E) Staining and Immunohistochemistry (IHC) to Determine the Efficacy of Vaccination against PRRS in Swine." Annual SROP Research Symposium, Columbus, August 2013.



8. Cierra Davis (2013), a Minority Internship Undergraduate Student, SROP, The Ohio State University, presented a poster - "Antibody-Dependent Cell-Mediated Cytotoxicity in Porcine Respiratory and Reproductive Syndrome." Annual SROP Research Symposium, Columbus, August 2013.



9. Cecilia Silva (2015), a Minority Internship Undergraduate Student, SROP, The Ohio State University, presented a poster - "Nanoparticle-based swine influenza virus vaccine study in pigs." Annual SROP Research Symposium, Columbus, July 2015.



10. Ninoshkaly Feliciano Ruiz (2016), a Minority Internship Undergraduate Student, SROP, The Ohio State University, presented a poster - "Histopathological analysis of the lungs of swine influenza virus challenged pig lungs vaccinated with in a nanoparticle based swine influenza vaccine challenge study." Annual SROP Research Symposium, Columbus, July 2016.



11. Akila Gopal (2016). OARDC Summer Research Internship Program, The Ohio State University, Oral presentation title, "Understand the cytokine mRNA expression profile of Poly-D, L-lactide-co glycolide nanoparticles based delivered vaccine in swine influenza virus infected piglets." Fisher Auditorium, OARDC, Wooster, August 2016.

Biographical

I am a veterinarian with 25 years of broad background and training in immunology in both large animal and murine models, with expertise in the areas of mucosal immunology related to virus-host interaction, viral pathogenesis, and vaccine development in food animals. I received DVM and MS degrees from Veterinary College, Bangalore, India. I completed my graduate education (PhD) in 2002 at the Indian Institute of Science, Bangalore, India. Subsequently, I joined Indiana University School of Medicine at Indianapolis for my post-doctoral training in the Department of Microbiology and Immunology. During five years of my training at the Indiana University, I worked on understanding the function of murine NKT cells in antiviral immune response as well as antitumor responses against murine B and T cell lymphomas.



In May 2008, I accepted a position of tenure track Assistant Professor at the Food Animal Health Research Program (FAHRP), Ohio Agricultural Research and Development Center, and College of Veterinary Preventive Medicine, The Ohio State University, located at the Wooster campus. My position has been a 100% commitment to research in the department, and provide research training to master and graduate students, postdocs, visiting fellows and summer undergraduate students. The main focuses of my research have been in the areas of mucosal immunology related to understanding mucosal immune responses and microbial pathogenesis in the respiratory tract of pigs and other species of food animals infected with infectious and zoonotic pathogens; as well as development and evaluation of inactivated virus vaccine candidates in pigs. In April 2013, I was promoted to Associate Professor with tenure at The Ohio State University.

Research Funding

Since I became an independent investigator in 2008 at FAHRP OARDC, Veterinary Preventive Medicine, The Ohio State University, I was awarded with two grants on PRRSV research from the United States Department of Agriculture under National Institute of Food and Agriculture (USDA-NIFA) to lead on multi-institutional projects with Dr. Michael Murtaugh (University of Minnesota) and the other with Dr. Ying Fang (Kansas State University). The aims of both the USDA funded research was to analyze immune mechanisms of protection in PRRSV infected and vaccinated pigs. In another USDA-NIFA grant award under dual-purpose dual-benefit grant category with Dr. Lee (OSU), a multi-PI award. The aim of the study was to analyze “Universal Flu Vaccine by a Norovirus P Particle Platform,� and my role is to understand immune correlates of protection to novel influenza virus vaccine candidates in pigs and poultry.In addition, since 2008, I was awarded with 5 research grants from National Pork Board; 5 awards from SEEDS grants program of OARDC Ohio State; 2 awards from Center for Clinical and Translational Sciences from Ohio state; 2 awards from iCorps program of Ohio department of higher education and University of Akron related to commercialization of influenza vaccines; 2 small industry grants to improve PRRS and influenza virus vaccine formulations; 3 exploratory seed grants from the Nanovaccine Research Initiative, Iowa State University. Overall, the aims of all these research grant awards have been on diverse areas, such as understanding host-pathogen interactions, analysis of various viral and bacterial vaccine formulations; including nanotechnology-based vaccine delivery platform against influenza and PRRSV in pig model.Notably, my laboratory discovered Natural Killer T (NKT) cell in pig and demonstrated NKT cell adjuvant effects using its agonist/ligand a-GalCer to inactivated SwIV H1N1 in intranasally vaccinated pigs. One of the future goals of my laboratory research is aimed to understand mechanisms of induction of Th1 and/or Th2 based immunity at the mucosal inductive sites of pig respiratory tract vaccinated with nasal nanoparticle-based influenza virus vaccine. As part of this goal, in a collaborative project with Dr. Prosper Boyaka, Veterinary Biosciences, Ohio State, we applied a NIH R01 grant application (under review). Aim of that proposal was to elucidate the mechanisms of induction of innate and adaptive immunity to a nasal nanoparticle-based influenza vaccine coadministered with the NKT cell adjuvant in SPF pig and mice model. In another area of research, an exploratory research project application was submitted to NIH R21 program with Dr. Piermarini, Department of Entomology, The Ohio State University. In that application, we proposed to determine Zika virus pathogenesis in a pig model, through understanding its perinatal transmission in baby piglets and fetal brain transmission from infected pregnant sows.

Academic Advising

2013 Jang, H., The Ohio State University, College of Veterinary Medicine. Graduated 0.
2013 Mohamed Salaheldin, The Ohio State University, College of Veterinary Medicine. Graduated 0.
2014 Ashley D, The Ohio State University - OARDC. Graduated 2015.
2015 Amanda Luoma,, The Ohio State University, College of Veterinary Medicine. Graduated 0.
2015 Yashvanth Lakshmanappa, The Ohio State University, College of Veterinary Medicine. Graduated 0. Evaluation of PRRSV vaccine candidates induced immune response in pigs
2015 Santosh Dhakal, The Ohio State University, College of Veterinary Medicine. Graduated 0. Development and elucidation of particulate swine influenza vaccine in pigs
2016 Brad Hogshead, The Ohio State University, College of Veterinary Medicine. Graduated 0. Determing the innate immune profiles of immunity to Influenza in pigs
2009 Matthew Weeman,, The Ohio State University, College of Veterinary Medicine. Graduated 2011. Study of mucosal immune response in the respiratory tract of pigs infected with porcine reproductive and respiratory syndrome
2010 Jayla Miller, The Ohio State University, College of Veterinary Medicine. Graduated 2014.
2010 Samyra Martin,, The Ohio State University, College of Veterinary Medicine. Graduated 2014. Characterization of Myeloid Derived Suppressor Cells in pigs
2011 Sha’Rayna Oree, The Ohio State University, College of Veterinary Medicine. Graduated 2015. NKT cell specific adjuvant potentiates mucosal immunity to killed swine influenza virus vaccine in pigs
2011 Skye Patterson, The Ohio State University, College of Veterinary Medicine. Graduated 0.
2011 Jayla Miller, The Ohio State University, College of Veterinary Medicine. Graduated 2014. Characterization of IL-10 and IL-12 producing myeloid cells in pigs infected with porcine reproductive and respiratory syndrome virus
2011 Rauf, Abdul, The Ohio State University. Graduated 2011.
2008 - 2012 Cordelia Manickam, The Ohio State University. Graduated 2013.
2012 Nadia Elkalifa,, The Ohio State University, College of Veterinary Medicine. Graduated 2015. Development of the oral fluid based diagnostic tool to diagnose herd immunity in pigs against PRRSV
2012 Sengupta A,, The Ohio State University. Graduated 0. Degradation of antibiotics in soil due to microbiological and enzymatic activity of soil
2012 - 2013 Kara Henn,, The Ohio State University, College of Veterinary Medicine. Graduated 2013. Development of novel mucosal vaccines against swine influenza virus in pigs
2013 Cierra Davis,, The Ohio State University, College of Veterinary Medicine. Graduated 2016. Antibody-Dependent Cell-Mediated Cytotoxicity in Porcine Respiratory and Reproductive Syndrome
2013 Lanre Odusote,, The Ohio State University, College of Veterinary Medicine. Graduated 2016.
2013 Persad, A., The Ohio State University, College of Veterinary Medicine. Graduated 2013. Survival of Shiga Toxin producing Escherichia coli and Salmonella serotypes in the feces of five (5) animal species
2013 Swapna Priya, The Ohio State University College of Food Agricultural and Environmental Sciences. Graduated 2013. Integrated omics on the physiology of emerald ash borer (Agrilus planipennis Fairmaire)
2013 - 2014 Matthew Walston,, The Ohio State University - OARDC. Graduated 2014. Studies on T-cell Properties during Coccidiosis and a Vitamin E Supplement to an in ovo Coccidiosis Vaccine
2013 - 2014 Brittany L., The Ohio State University, College of Veterinary Medicine. Graduated 2014. Evaluation of humoral immune response in pigs vaccinated with nanoparticle-entrapped PRRS virus vaccine
2013 - 2014 John Michael, The Ohio State University, College of Veterinary Medicine. Graduated 2014. Evaluation of antiody response in pigs to PRRS virus vaccine
2013 - 2014 Lulu Shao, The Ohio State University. Graduated 0.
2013 - 2014 Hiremath, J., The Ohio State University. Graduated 0.
2013 - 2014 Binjawadagi, B., The Ohio State University. Graduated 0.
2014 Tanush Jagadish, The Ohio State University, College of Veterinary Medicine. Graduated 0.
2014 Shashank Jayakumar, The Ohio State University, College of Veterinary Medicine. Graduated 0.
2012 - 2015 Lulu Shao, The Ohio State University, College of Veterinary Medicine. Graduated 2015.
2012 - 2015 Binjawadagi, B., The Ohio State University. Graduated 2015. Evaluation of immune correlates of protection in pigs immunized intranasally with PRRS virus killed vaccines
2013 - 2015 Santosh Dhakal, The Ohio State University, College of Veterinary Medicine. Graduated 2015.
2013 - 2015 Shyu, D-L., The Ohio State University, College of Veterinary Medicine. Graduated 2015.
2014 - 2015 Jang, H., The Ohio State University, College of Veterinary Medicine. Graduated 0.
2015 Cecilia Silva,, The Ohio State University, College of Veterinary Medicine. Graduated 0.
2016 Ninoshkaly Feliciano-Ruiz,, American University of Puerto Rico. Graduated 0.
2016 Akila Gopal, University Of Akron. Graduated 0.
 

Licenses

2015 - present Manufacturing and sales of autogenous and commercial vaccines for the prevention and/or treatment of Porcine Reproductive and Respiratory Syndrome (PRRS) virus. Aptimmune Biologics, Inc., Champaign, Illinois.: The Ohio State University
 

Chapters in Books

Liu J; Renukaradhya GJ; Brutkiewicz RR. "The regulation of CD1d+ and CD1d- tumors by NKT cells. Balancing the Regulation of Tumor Immunity." In Balancing the Regulation of Tumor Immunity. Edited by Terabe M and Berzofsky JA. 71-94. New York, NY, US|USA: Springer Science+Business Media, LLC, January 2011.

Shaila, MS, Renukaradhya, GJ.. "Host Immune Responses Against Peste des Petits Ruminants Virus." In Peste des Petits Ruminants Virus. Edited by Muhammad Munir. -.

Hodgins DC, Chattha K, Vlasova A, Parreno V, Corbeil LB, Renukaradhya GJ, and Saif LF. "Porcine reproductive and respiratory syndrome." In Mucosal Veterinary Vaccines: Comparative Vaccinology. Edited by Hodgins DC. -.

 

Editorial Activities

2009 - present PLoS ONE
2009 - 2012 OARDC Graduate Student Poster Competition, The Ohio State University
2010 - present Animal Health Research Reviews
2010 - present Journal of General Virology
2010 - present Gastroenterology
2010 - present Center for Microbial Interface Biology Retreat for Graduate Student Poster Competition
2010 - present The Journal of Immunology
2010 9th International Veterinary Immunology Society meeting Graduate Student Poster Competition at Tokyo, Japan,
2011 - present Folia Microbiologica
2011 - present Clinical Immunology
2011 - present Canadian Swine Health Board - Grant review study section team
2012 - present Virology & Mycology - OMICS: A Journal of Integrative Biology
2012 - present MDPI Virology
2012 - present ISRN Virology -- International Scholarly Research Network
2012 - present Internatonal Journal of Molecualr Sciences
2012 - present PLoS ONE
2012 - present BMC Veterinary Research
2012 - present Developmental and Comparative Immunology
2013 - present Avian Diseases
2013 - present Archives of Virology
2013 - present Journal of Veterinary Science & Animal Husbandry
 

Honors

2010 American Association of Veterinary Immunologists (AAVI) Junior Faculty Travel Award. 9th International Veterinary Immunology Society meeting, American Association of Veterinary Immunologists.
2010 American Association of Immunologists (AAI) Junior Faculty Travel Award. 97th Annual meeting, American Association of Immunologists.
2012 Travel Award to attend 6th International Veterinary Vaccines and Diagnostic Conference, Cairns, Queensland, Australia.. USDA.
2013 Early Career Investigator Award. American Association of Immunologists.
2013 Junior Faculty Travel Award. American Association of Veterinary Immunologists (AAVI), USDA/NIFA.
2014 AAI Laboratory Travel Grant Award. American Association of Immunologists.
2016 AAI Laboratory Travel Grant Award. American Association of Immunologists.
 

Journal Articles

Binjawadagi B, S.L. Yashavanth, Z. Longchao, S. Dhakal, J. Hiremath, K. Ouyang, D-L. Shyu, J. Arcos, A. Gilbertie, F. Zuckermann, J.B. Torrelles, D. Jackwood, Y. Fang, and G.J. Renukaradhya. "Development of porcine reproductive and respiratory syndrome virus-like-particle and evaluation of its immunogenicity in pigs." Archives of Virology. (January 0.): -.

Tabynov, K, Sansyzbay A, Tulemissova, Z, Dhakal, S, Renukaradhya, GJ, and Mambetaliyev, M. "Inactivated porcine reproductive and respiratory syndrome virus vaccine adjuvanted with MontanideTM Gel 01 ST elicits virus-specific cross-protective inter-genotypic response in piglets." Veterinary Microbiology. (January 0.): -.

Binjawadagi, B, Dwivedi, V, Manickam, C, Ouyang, K, Torrelles, JB, Renukaradhya, GJ.. "An innovative approach to induce cross-protective immunity against porcine reproductive and respiratory syndrome virus in the lungs of pigs through adjuvanted nanotechnology based vaccination." International Journal of Nanomedicine. (January 0.): -.

Renukaradhya, GJ, Meng, X-J, Calvert, JG, Roof, M, Lager, KM.. "). Live porcine reproductive and respiratory syndrome virus-based vaccines: current status and future direction." Vaccine. (January 0.): -.

Renukaradhya, G.J.*, S. Isloor and M. Rajasekhar. "Epidemiology, zoonotic aspects, vaccination and control / eradication of brucellosis in India." Veterinary Microbiology. Vol. 90, no. 1-4. (December 2002.): 183-195.

Renukaradhya,GJ, Alekseev, KP, Jung, K, Fang, Y, and Saif, LJ.. "Porcine reproductive and respiratory syndrome virus induced immunosuppression exacerbate the inflammatory response to porcine respiratory coronavirus in pigs." Viral Immunol. Vol. 23 *Corresponding author, no. 5. (October 2010.): 457-466.

Khatri M; Dwivedi V; Krakowka S; Manickam C; Ali A; Wang L; Qin Z; Renukaradhya GJ*; Lee CW*. "Swine influenza virus induces acute inflammatory immune responses in pig lungs: a potential animal model to understand human pandemic H1N1 influenza virus." J. Virol.. Vol. 84 *Corresponding authors, no. 21. (November 2010.): 11210-11218.

Yassine KM; Lee CW; Renukaradhya GJ; Saif YM. "Interspecies and intraspecies transmission of influenza A viruses: viral, host and environmental factors." Animal Health Research Reviews. Vol. 11, no. 1. (June 2010.): 53-72.

Jung, K, Gurnani, A, Renukaradhya, GJ, and Saif, LJ.. "Nitric oxide is elicited and inhibits viral replication in pigs infected with porcine respiratory coronavirus but not porcine reproductive and respiratory syndrome virus." Vet. Immunol. Immunopath. Vol. 136, (January 2010.): 335-339.

Dwivedi. V; C. Manickam; R. Patterson; K. Dodson; M. Murtaugh; J.B. Torrelles; L.S. Schlesinger; G.J. Renukaradhya. "Cross-protective immunity to porcine reproductive and respiratory syndrome virus by intranasal delivery of a live virus vaccine with a potent adjuvant." Vaccine. Vol. 23, no. 29. (January 2011.): 4058-4066.

Dwivedi. V; C. Manickam; R. Patterson; K. Dodson; M. Weeman; and G.J. Renukaradhya. "Intranasal delivery of whole cell lysate of Mycobacterium tuberculosis induces protective immune responses to a modified live porcine reproductive and respiratory syndrome virus vaccine in pigs." Vaccine. Vol. 23, no. 29. (January 2011.): 4067-4076.

Binjawadagi B, V. Dwivedi, C. Manickam, J.B. Torrelles, and G.J. Renukaradhya. "Intranasal delivery of an adjuvanted modified live porcine reproductive and respiratory syndrome virus vaccine reduces the ROS production." Viral Immunology. Vol. 6, no. 24. (January 2011.): 475-482.

Renukaradhya GJ*; Manickam C; Khatri M; Rauf A; Li X; Tsuji M; Rajashekara G; Dwivedi V. "Functional Invariant NKT Cells in Pig Lungs Regulatethe Airway Hyperreactivity: A Potential Animal Model." J Clin Immunol. Vol. 2, no. 31. (January 2011.): 228-239.

Khandelwal A; Renukaradhya GJ; Rajasekhar M; Lakshmi Sita G; Shaila MS. "Immune responses to Hemagglutinin-Neuraminidase protein of peste des petits ruminants virus expressed in transgenic peanut plants in sheep." Vet. Immunol. Immunopath.. Vol. 3-4, no. 140. (January 2011.): 291-296.

Dwivedi V; Manickam C; Binjawadagi B; Patterson R: Linhares D; Murtaugh MP; Renukaradhya GJ. "Evaluation of immune responses to porcine reproductive and respiratory syndrome virus in pigs during early stage of infection." Virology Journal. Vol. 45, no. 9. (February 2012.): 1-7.

Renukaradhya, GJ, Dwivedi, V, Manickam, C, Binjawadagi, B, Benfield, D.. "Mucosal vaccines to control porcine reproductive and respiratory syndrome: a new perspective." Animal Health Research Review, June 2012. Vol. 1, (May 2012.): 21-37.

Renukaradhya, GJ,. "Adjuvant Improves Response of PRRS Vaccine." National Hog Farmer. Vol. 1, (December 2012.): 1-2.

Dwivedi V, C. Manickam, B. Binjawadagi, Joyappa, D, and G.J. Renukaradhya. "Biodegradable nanoparticle-entrapped vaccine induces cross-protective immune response against a virulent heterologous respiratory viral infection in pigs." PLOS One. Vol. 7, no. 12. (December 2012.): e51794-.

Manickam C, V. Dwivedi, R. Patterson, K. Dodson and G.J. Renukaradhya. "Porcine reproductive and respiratory syndrome virus induces pronounced immune modulatory responses at mucosal tissues in the parental vaccine strain VR2332 infected pigs." Veterinary Microbiology. Vol. 162, (December 2012.): 68-77.

Broxmeyer, HE, Christopherson, K, Hangoc, G, Cooper, S, Mantel, C, Renukaradhya, GJ, and Brutkiewicz, RR.. "CD1d Expression on and regulation of murine hematopoietic stem and progenitor cells." Blood 2012 Apr 25.. Vol. 119, no. 24. (April 2012.): 5731-5741.

Gourapura,Renukaradhya,J; Khan,Masood,A; Gallo,Richard,M; Shaji,Daniel; Liu,Jianyun; Brutkiewicz,Randy,R. "Forming a Complex with MHC Class I Molecules Interferes with Mouse CD1d Functional Expression." PLOS ONE. Vol. 8, no. 8. (August 2013.): e72867-.

Annamalai, TR, Pina-Mimbela, Kumar, A, Binjawadagi, B, Renukaradhya, GJ, and Rajashekara, G. "Evaluation of nanoparticle encapsulated OMPs for the control of Campylobacter jejuni colonization in chickens." Poultry Science. Vol. 92, (July 2013.): 2201-2211.

Dwivedi, V, Manickam, C, Binjawadagi, B, and Renukaradhya, GJ. "PLGA nanoparticle entrapped killed porcine reproductive and respiratory syndrome virus vaccine helps in viral clearance in pigs." Vet. Microbiol.,. Vol. 166, no. 1-2. (July 2013.): 47-58.

Renukaradhya, GJ, Khan, MA, Gallo, RM, Shaji, D, Liu, J, and Brutkiewicz, RR.. "Forming a complex with MHC class I molecules interferes with mouse CD1d functional expression." PLoS One. Vol. 8, no. 8. (August 2013.): e72867-.

Olsen, C, Karriker,L, Wang, C, Renukaradhya, J, Binjawadagi, B, Kittawornrat, A, Lizano, S, Coetzee, J, Main, R, Meiszberg, A, Panyasing, Y, and Zimmerman, JJ.. "Effect of collection material on pig oral fluid testing results." Veterinary Journal. Vol. 198, no. 1. (October 2013.): 158-163.

Manickam C, V. Dwivedi, J. Miller, T. Papenfuss and G.J. Renukaradhya. "Mycobacterium tuberculosis whole cell lysate enhances proliferation of CD8 positive lymphocytes and nitric oxide secretion in the lungs of live porcine respiratory and reproductive syndrome virus vaccinated pigs." Viral Immunol.. Vol. 26, no. 1. (January 2013.): 102-108.

Ouyang K, Binjawadagi, B, Kittawornrat, A, Olsen, C, Hiremath, J, Elkalifa, N, Schleappi, R, Wu, J, Zimmerman, J, Renukaradhya, GJ. "Development and Validation of an Assay To Detect Porcine Reproductive and Respiratory Syndrome Virus-Specific Neutralizing Antibody Titers in Pig Oral Fluid Samples." Clinical and Vaccine Immunology. Vol. 20, no. 8. (July 2013.): 1305-1313.

Binjawadagi, B, Dwivedi, V, Manickam, C, Torrelles, JB, Ouyang, K, Wu, Y, Lee, J, Torrelles, JB, and Renukaradhya, GJ.. "Adjuvanted nanoparticle-entrapped inactivated porcine reproductive and respiratory syndrome virus vaccine elicits better cross-protective response in pigs." International Journal of Nanomedicine. Vol. 9, (January 2014.): 679-694.

Bailey, J, Abhirami, I, Renukaradhya, GJ, Yinling, L, Hoa, N, Brutkiewicz, RR.. "Inhibition of CD1d-mediated Antigen Presentation by the TGF-β/Smad Signaling Pathway." Immunology. Vol. 143, no. 4. (August 2014.): 679-691.

Binjawadagi, B, Dwivedi, V, Manickam, C, Ouyang, K, Torrelles, JB, and Renukaradhya, GJ. "An innovative approach to induce cross-protective immunity against porcine reproductive and respiratory syndrome virus in the lungs of pigs through adjuvanted nanotechnology based vaccination." International Journal of Nanomedicine. Vol. 9, (April 2014.): 1519-1535.

Ouyang K, Woodiga, SA, Dwivedi, V, Buckwalter, CM, Singh, AK, Binjawadagi, B, Hiremath, J, Manickam, C, Schleappi, R, Khatri, M, Wu, J, King, SJ, and Renukaradhya, GJ. "Pretreatment of epithelial cells with live Streptococcus pneumoniae has no detectable effect on influenza A virus replication in vitro." PLoS One. Vol. 9, no. 3. (March 2014.): e90066-.

Ouyang, K, Shyu, D-L, Dhakal, S, Hiremath, J, Binjawadagi, B, Yashavanth, SL, Guo, R, Ransburgh, R, Bondra, KM, Gauger, P, Zhang, J, Specht, T, Gilbertie, A, Minton, W, Fang, Y, and Renukaradhya, GJ.. "Evaluation of humoral immune status in porcine epidemic diarrhea virus (PEDV) infected sows under field conditions." Veterinary Research. Vol. 46, no. 1. (December 2015.): 140-.

Thomas, M, Wang, Z, Sreenivasan, CC, Hause, BM, Renukaradhya, GJ, Li, F, Francis, DH, Kaushik, RS, Khatri, M.. "Poly I:C adjuvanted inactivated swine influenza vaccine induces heterologous protective immunity in pigs." Vaccine. Vol. 33, no. 4. (April 2015.): 542-548.

Renukaradhya, GJ, Meng, X-J, Calvert, JG, Roof, M, and Lager, KM.. "Inactivated and subunit vaccines against porcine reproductive and respiratory syndrome: Current status and future direction." Vaccine. Vol. 33, no. 27. (June 2015.): 3065-3072.

Renukaradhya, GJ, Meng, X-J, Calvert, JG, Roof, M, and Lager, KM.. "Live porcine reproductive and respiratory syndrome virus-based vaccines: current status and future direction." Vaccine. Vol. 33, no. 33. (August 2015.): 4069-4080.

Lunney, JK, Fang, Y, Ladinig, A, Chen, N, Li, Y, Rowland, B, and Renukaradhya, GJ.. "Porcine reproductive and respiratory syndrome virus (PRRSV): Pathogenesis and Interaction with the Immune System." Annual Review of Animal Biosciences. Vol. 14, (November 2015.): 25-.

Renukaradhya, GJ, Narasimhan, B, and Mallapragada, SK. "Respiratory nanoparticle-based vaccines and challenges associated with animal models and translation." Journal of Control Release. Vol. 219, (December 2015.): 622-631.

Ouyang, K, J. Hiremath, B. Binjawadagi, D-L. Shyu, S. Dhakal, J. Arcos, R. Schleappi, L. Holman, M. Roof, J.B. Torrelles, and G.J. Renukaradhya. "Comparative analysis of routes of immunization of a live porcine reproductive and respiratory syndrome virus (PRRSV) vaccine in a heterologous virus challenge study." Veterinary Research. Vol. 47, no. 1. (March 2016.): 45-.

Dwivedi V, C. Manickam, S. Dhakal, B. Binjawadagi, K. Oyuang, J. Hiremath, M. Khatri, J. Gervey-Hague, C-W. Lee, and G.J. Renukaradhya. "Adjuvant effects of invariant NKT cell ligand potentiates the innate and adaptive immunity to an inactivated H1N1 swine influenza virus vaccine in pigs." Veterinary Microbiology. Vol. 186, (April 2016.): 157-163.

Yanhua, L, Shyu, D-L, Shang, P, Bai, J, Ouyang, K, Dhakal, S, Hiremath, JH, Binjawadagi, B, Renukaradhya, GJ, and Fang, Y.. "Mutations in a highly conserved motif of nsp1β protein attenuate the innate immune suppression function of porcine reproductive and respiratory syndrome virus (PRRSV)." Journal of Virology. Vol. 90, no. 7. (January 2016.): 3584-3599.

Hiremath J, Kyung-il K, Elaish M, Binjawadagi B, Ouyang K, Dhakal S, Torrelles JB, Lee C-W, and Renukaradhya GJ. "Entrapment of H1N1 influenza virus derived conserved peptides in PLGA nanoparticles enhances T cell response and vaccine efficacy in pigs." PLOS One. Vol. 11, no. 4. (April 2016.): e0151922-.

Manickam C, Dwivedi V, Miller J, Papenfuss T and Renukaradhya GJ. "Mycobacterium tuberculosis whole cell lysate enhances proliferation of CD8 positive lymphocytes and nitric oxide secretion in the lungs of live porcine respiratory and reproductive syndrome virus vaccinated pigs." Viral Immunology. -.

Dwivedi, V, Manickam, C, Binjawadagi, B, Joyappa, D, and Renukaradhya, GJ. "Biodegradable nanoparticle-entrapped vaccine induces cross-protective immune response against a virulent heterologous respiratory viral infection in pigs." PLoS ONE. -.

Manickam, C; V. Dwivedi; ; R. Patterson; K. Dodson; M. Weeman; and G.J. Renukaradhya. "Porcine reproductive and respiratory syndrome virus induces pronounced immune modulatory responses at mucosal tissues in the parental vaccine strain VR2332 infected pigs." Veterinary Microbiology. -.

Bailey J, Abhirami, I, Renukaradhya, GJ, Yinling, L, Hoa, N, Brutkiewicz, RR. "Inhibition of CD1d-mediated Antigen Presentation by the TGF-β/Smad Signaling Pathway." Immunology. -.

Thomas, M, Wang, Z, Sreenivasan, CC, Hause, BM, Renukaradhya, GJ, Li, F, Francis, DH, Kaushik, RS, and Khatri, M.. "Poly I:C adjuvanted inactivated swine influenza vaccine induces heterologous protective immunity in pigs." Vaccine. -.

 

Reference Works

December 2009 Dwivedi, V., C. Manickam, R. Patterson, K. Dodson, and G. J. Renukaradhya."Steps towards development of a novel mucosal vaccine to PRRSV" . : 84
December 2009 Dwivedi, V., C. Manickam, R. Patterson, K. Dodson, and G. J. Renukaradhya."Steps towards development of a novel mucosal vaccine to PRRSV" . : 110
December 2010 Dwivedi, V; C. Manickam; B. Binjawadagi; R. Patterson; K. Dodson; and G. J. Renukaradhya."Mucosal immunization with biodegradable PLG- nanoparticles elicits effective anti-PRRSV immune responses in Pigs" Chicago. : No. 129
August 2010 Dwivedi V; C. Manickam; R. Patterson; K. Dodson; M. Murtaugh; J. Torrelles; L. Schlesinger; and G.J. Renukaradhya."Mucosal vaccine to protect against porcine reproductive and respiratory syndrome: a new perspective" Tokyo. : 84
December 2010 Dwivedi, V; C. Manickam; B. Binjawadagi; R. Patterson; K. Dodson; and G. J. Renukaradhya."Mucosal immunization with biodegradable PLG- nanoparticles elicits effective anti-PRRSV immune responses in Pigs" Chicago. : 66
December 2010 Manickam, C; V. Dwivedi; M. Khatri; R. Patterson; T. Papenfus; and G. J. Renukaradhya."Mucosal adjuvanticity of M.tb whole cell lysate to PRRSV live vaccine leads to a better immunostimulation and protection against PRRSV challenge" Chicago. : 9
November 2010 Dwivedi, V; C. Manickam; B. Binjawadagi; R. Patterson; K. Dodson; and G. J. Renukaradhya."Mucosal immunization with biodegradable PLG- nanoparticles elicits effective anti-PRRSV immune responses in Pigs" Columbus.
November 2010 Dwivedi, V., C. Manickam, B. Binjawadagi, R. Patterson, K. Dodson, and G. J. Renukaradhya."Mucosal immunization with biodegradable PLG- nanoparticles elicits effective anti-PRRSV immune responses in Pigs" Columbus.
December 2010 Manickam, C; V. Dwivedi; M. Khatri; R. Patterson; T. Papenfus; and G. J. Renukaradhya."Mucosal adjuvanticity of M.tb whole cell lysate to PRRSV live vaccine leads to a better immunostimulation and protection against PRRSV challenge" Chicago. : No. 133
May 2010 G.J. Renukaradhya; C. Manickam; V. Dwivedi."Invariant NKT cells in pig lung: a potential asthma model" Baltimore. : 271
May 2011 Dwivedi, V., C. Manickam, B. Binjawadagi, M. Khatri, R. Patterson, and G. J. Renukaradhya.."Mucosal immunization with biodegradable PLG- nanoparticles elicits effective anti-PRRSV immune responses in Pigs" SanFranscico. : 305
December 2011 Manickam, C., V. Dwivedi, R. Patterson, T. Papenfuss, and G. J. Renukaradhya."Differential regulation of mucosal immune responses at various mucosal tissues in pigs infected with PRRSV strain VR2332" Chicago. : 52
December 2011 Manickam, C., V. Dwivedi, R. Patterson, T. Papenfuss, and G. J. Renukaradhya."Differential regulation of mucosal immune responses at various mucosal tissues in pigs infected with PRRSV strain VR2332" Chicago. : No.117
December 2011 Dwivedi, V., C. Manickam, B. Binjawadagi, R. Patterson, and G. J. Renukaradhya."Nanoparticles entrapped killed PRRSV vaccine reduces PRRSV viremia in both homologous and heterologous PRRSV challenged pigs" Chicago. : 58
December 2011 Dwivedi, V., C. Manickam, B. Binjawadagi, R. Patterson, and G. J. Renukaradhya."Nanoparticles entrapped killed PRRSV vaccine reduces PRRSV viremia in both homologous and heterologous PRRSV challenged pigs" Chicago. : No. 120
December 2011 Dwivedi, V., C. Manickam, B. Binjawadagi, D. Linhares, M. P. Murtaugh, and G. J. Renukaradhya."Evaluation of immune responses to porcine reproductive and respiratory syndrome virus in pigs at day two post-infection" Chicago. : 81
December 2011 Dwivedi, V., C. Manickam, B. Binjawadagi, D. Linhares, M. P. Murtaugh, and G. J. Renukaradhya."Evaluation of immune responses to porcine reproductive and respiratory syndrome virus in pigs at day two post-infection" Chicago. : No. 141
December 2011 Binjawadagi, B., V. Dwivedi, C. Manickam, J. B. Torrelles, and G. J. Renukaradhya."Intranasal delivery of an adjuvanted modified live porcine reproductive and respiratory syndrome virus vaccine reduces the ROS induced lung pathology" Chicago. : 43
December 2011 Binjawadagi, B., V. Dwivedi, C. Manickam, J. B. Torrelles, and G. J. Renukaradhya."Intranasal delivery of an adjuvanted modified live porcine reproductive and respiratory syndrome virus vaccine reduces the ROS induced lung pathology" Chicago. : No. 178
December 2012 Olsen C, L. Karriker, C, Wang, S. Abate, B. Binjawadagi, J. Christopher-Hennings, K. Doolittle, K. Harmon, A. Kittawornrat, A. Kurtz, E. Kurtz, S. Lizano, J. Coetzee, R. Main, A. Meiszberg, E. Nelson, T. Otterson, Y. Panyasing, C. Rademacher, R. Rauh, G.J. Renukaradhya, R. Shah, J. Zimmerman."Diagnostics" Chicago.
December 2012 Manickam C, K. Ouyang, B. Binjawadagi, K. Henn, P. Crittenden, J. Hiremath, M. Khatri and G. J. Renukaradhya."Respiratory diseases" Chicago.
December 2012 Binjawadagi B, V. Dwivedi, C. Manickam, K. Ouyang, J.B. Torrelles, and G. J. Renukaradhya."Immnology Section" Chicago.
November 2012 Olsen, C, Karriker L, Wang C, Abate S, Binjawadagi B, Christopher-Hennings J, Doolittle K, Harmon K., A. Kittawornrat, A. Kurtz, E. Kurtz, S. Lizano, J. Coetzee, R. Main, A. Meiszberg, E. Nelson, T. Otterson, Y. Panyasing, C. Rademacher, R. Rauh, G.J. Renukaradhya, R. Shah, J. Zimmerman."Diagnostics" Ames, Iowa.
April 2012 Manickam, C, Dwivedi, V, Patterson, R, Dodson, K, Papenfuss, T, Renukaradhya, GJ."PRRSV Pathogenesis" Columbus.
April 2012 Manickam, C, Dwivedi, V, Patterson, R, Dodson, K, Papenfuss, T, Renukaradhya, GJ."PRRSV Pathogenesis" Wooster.
April 2012 Dwivedi, V, Manickam, C, Renukaradhya, GJ,."Influenza pathogenesis" Columbus.
April 2012 Binjawadagi, B, Dwivedi, V, Manickam, C, Ouyang, K, Torrelles, JB, Renukaradhya, GJ."PRRSV vaccine" Columbus.
April 2012 Binjawadagi, B, Dwivedi, V, Manickam, C, Ouyang, K, Torrelles, JB, Renukaradhya, GJ."PRRSV vaccine" Wooster.
November 2012 Ouyang K, B. Binjawadagi, N. Elkalifa, J. Wu, C. Olsen J.B. Torrelles, J. Zimmerman, and G. J. Renukaradhya."PRRS symposium" Kansas City.
December 2012 Ouyang K, B. Binjawadagi, N. Elkalifa, J. Wu, C. Olsen J.B. Torrelles, J. Zimmerman, and G. J. Renukaradhya."Respiratory diseases" Chicago.
May 2012 Dwivedi, V, Manickam, C, Renukaradhya, GJ,."Influenza pathogenesis" Columbus.
July 2012 Binjawadagi, B, Dwivedi, V, Manickam, C, Torrelles, JB, Renukaradhya, GJ."PRRSV vaccine" Cairns.
November 2012 Binjawadagi B, V. Dwivedi, C. Manickam, K. Ouyang, J.B. Torrelles, and G. J. Renukaradhya."PRRS symposium" Kansas City.
December 2013 Hiremath, J, K. Ouyang, B. Binjawadagi, C. Manickam, S. Dhakal, V. Dwivedi, and G.J. Renukaradhya."Immnology Section" Chicago.
December 2013 Ouyang, K. B. Binjawadagi, A. Kittawornrat, C. Olsen, J. Hiremath, N. Elkalifa, R. Schleappi, J. Wu, J.J. Zimmerman, and G.J. Renukaradhya."Immnology Section" Chicago.
May 2013 Renukaradhya, G. J, C. Manickam, V. Dwivedi, K. Ouyang, B. Binjawadagi, K. Henn, J. Hiremath, S. Raghunath, P. Crittenden, and M. Khatri."Veterinary and Comparative Immunology" Honolulu. : 150
May 2013 Ouyang K, B. Binjawadagi, N. Elkalifa, J. Wu, C. Olsen J.B. Torrelles, J. Zimmerman, and G. J. Renukaradhya."Diagnostics and Vaccines" Beijing.
July 2013 Renukaradhya, G. J, C. Manickam, V. Dwivedi, K. Ouyang, B. Binjawadagi, K. Henn, J. Hiremath, S. Raghunath, P. Crittenden, and M. Khatri."Immunology and Vaccines" Vancouver. : F31
December 2014 Hiremath, J, M. Elaish, K. Kyung-il, B. Binjawadagi, K. Ouyang, S. Dhakal, C.W. Lee, and G.J. Renukaradhya."Immunology Section" Chicago.
December 2014 Ouyang, K, J. Hiremath, B. Binjawadagi, and G.J. Renukaradhya."PRRS vaccines and diagnostics" Chicago.
May 2014 Iyer, A, L. J. Bailey, G.J. Renukaradhya, Y. Lin, H. Nguyen, and R.R. Brutkiewicz."Immnology Section" Pittsburg.
December 2014 Ouyang, K, J. Hiremath, B. Binjawadagi, and G.J. Renukaradhya."PRRS vaccines and diagnostics" Chicago.
December 2014 Lee, C-W, K. Kang, M. Elaish, J.M. Ngunjiri, H. Jang, A. Ali, J. Hiremath, S. Dhakal, M. Xia, X. Jiang, and G.J. Renukaradhya."Respiratory Disease Section" Chicago.
May 2014 Hiremath, J, B. Binjawadagi, K. Ouyang, S. Dhakal, C. Manickam, V. Dwivedi, and G.J. Renukaradhya."Immnology Section" Pittsburg.
May 2014 Binjawadagi, B, V. Dwivedi, C. Manickam, K. Ouyang, Torrelles, J, and G.J. Renukaradhya."Immnology Section" Pittsburg.
December 2014 Thomas M, Z. Wang, C.C. Sreenivasan, B.M. Hause, G.J. Renukaradhya, F. Li, D.H. Francis, R.S. Kaushik and M. Khatri."Respiratory Disease Section" Chicago.
December 2014 Binjawadagi, B, Z. Longchao, S. Dhakal, J. Hiremath, K. Ouyang, B. Shyu, J. J. Torrelles, D. Jackwood, Y. Fang, and G.J. Renukaradhya."PRRS Vaccines and Diagnostics" Chicago.
May 2014 Renukaradhya, G. J, Ouyang K, S. Woodiga, V. Dwivedi, C. Marion, A. Singh, B. Binjawadagi, J. Hiremath, C. Manickam, R. Schelappi, M. Khatri, and S. King."Immnology Section" Pittsburg.
May 2015 Dhakal, S., J. Hiremath, J. Goodman, Y. S. Lakshmanappa, B. Shyu, K. Oyuang, B. Narasimhan, G.J. Renukaradhya."Annual meeting" Ames, Iowa.
September 2015 Renukaradhya, G.J, Hiremath, J, M. Elaish, K. Kyung-il, B. Binjawadagi, K. Ouyang, S. Dhakal, and C.W. Lee."Swine Vaccines and Immunology" Vienna.
January 2015 Renukaradhya, G.J, Hiremath, J, M. Elaish, K. Kyung-il, B. Binjawadagi, K. Ouyang, S. Dhakal, and C.W. Lee."Keystone Symposia: Immunity to Veterinary Pathogens: Informing Vaccine Development" Keystone Resort.
October 2015 Renukaradhya, GJ, Dhakal, S, and Brummet, S.."I-Corps" Columbus.
December 2015 Dhakal, S., J. Hiremath, J. Goodman, Y.S. Lakshmanappa, D-L. Shyu, K. Oyuang, B. Narasimhan, and G.J. Renukaradhya."Immunology Section" Chicago.
December 2015 Ouyang, K., D-L Shyu, S. Dhakal, J. Hiremath, B. Binjawadagi, Y. S. Lakshmanappa, R. Guo, R. Ransburgh, K. M. Bondra, P. Gauger, J. Zhang, T. Specht, A. Gilbertie, W. Minton, Y. Fang, and G. J. Renukaradhya."PRRS Vaccines and Diagnostics" Chicago.
December 2015 Ouyang, K., D-L Shyu, S. Dhakal, J. Hiremath, B. Binjawadagi, Y. S. Lakshmanappa, R. Guo, R. Ransburgh, K. M. Bondra, P. Gauger, J. Zhang, T. Specht, A. Gilbertie, W. Minton, Y. Fang, and G. J. Renukaradhya."Immunology Section" Chicago.
December 2015 Lunney, J.K., M Bailey, A. Crossman, G.J. Renukaradhya, J. Labresh, S. Elankumaran, Y. Sang, and L. Wooldridge."Immunology Section" Chicago.
December 2015 Li, Y., D-L. Shyu, P. Shang, J. Bai, K. Ouyang, S. Dhakal, J. Hiremath, B. Binjawadagi, G. J. Renukaradhya, and Y. Fang."Respiratory Disease Section" Chicago.
December 2015 Li, Y., D-L. Shyu, P. Shang, J. Bai, K. Ouyang, S. Dhakal, J. Hiremath, B. Binjawadagi, G. J. Renukaradhya, and Y. Fang."PRRS Vaccines and Diagnostics" Chicago.
December 2015 Shyu, D-L., Y. Li, K. Ouyang, S. Dhakal, J. Hiremath, B. Binjawadagi, P. Shang, Y. Fang, and G. J. Renukaradhya."Immunology Section" Chicago.
December 2015 Shang, P., Y. Li, D-L. Shyu, C. Carrillo, P. Naraghi-Arani, G. J. Renukaradhya, J. Henningson, and Y. Fang."PRRS Vaccines and Diagnostics" Chicago.
December 2015 Shang, P., Y. Li, D-L. Shyu, C. Carrillo, P. Naraghi-Arani, G. J. Renukaradhya, J. Henningson, and Y. Fang."Respiratory Disease Section" Chicago.

Presentations

"Evaluation of adjuvants at the mucosal area for the development of innovative mucosal vaccine against PRRS." Presented at USDA and NPB meeting - Invited Presentation, Des Moines, IA, US|USA. (June 2009)

"Alternative models for study of respiratory diseases: Pig is a useful animal model to address both infectious and non-infectious lung diseases." Presented at Immunologists Round Table meeting - Invited Presentation, Columbus, OH, US|USA. (November 2010)

"A non-radioactive colorimetric assay to detect Natural Killer cell-mediated cytotoxicity." Presented at Immunologists Round Table Meeting - Invited Presentation, Wooster, OH, US|USA. (February 2010)

"Development of novel mucosal vaccines for the control of PRRS outbreaks.." Presented at USDA NPB meeting - Invited Presentation, Des Moines, IA, US|USA. (June 2010)

"Mucosal vaccine to protect against porcine reproductive and respiratory syndrome: a new perspective." Presented at 9th International Veterinary Immunology Society (IVIS) meeting - Invited Presentation, Tokyo, JP|JPN. (August 2010)

"Mucosal immunization with biodegradable PLG- nanoparticles elicits effective anti-PRRSV immune responses in Pigs." Presented at International PRRS Symposium 2010, Chicago, IL, US|USA. (December 2010)

"Mucosal immunization with biodegradable PLG- nanoparticles elicits effective anti-PRRSV immune responses in Pigs." Presented at CRWAD Meeting, Chicago, IL, US|USA. (December 2010)

"Mucosal adjuvanticity of M.tb whole cell lysate to PRRSV live vaccine leads to a better immunostimulation and protection against PRRSV challenge." Presented at CRWAD Meeting, Chicago, IL, US|USA. (December 2010)

"Mucosal adjuvanticity of M.tb whole cell lysate to PRRSV live vaccine leads to a better immunostimulation and protection against PRRSV challenge." Presented at International PRRS Symposium 2010, Chicago, IL, US|USA. (December 2010)

"Mucosal vaccine to protect against porcine reproductive and respiratory syndrome: a new perspective." Presented at Association of Microbiologists - Invited Presentation, Bangalore, IN|IND. (August 2010)

"Invariant NKT cells in pig lung: a potential asthma model." Presented at 97th Annual Meeting, American Association of Immunologists, Immunology 2010, Baltimore, MD, US|USA. (May 2010)

"Mucosal immunization with biodegradable PLG- nanoparticles elicits effective anti-PRRSV immune responses in Pigs." Presented at Fourth International Scholar Research Exposition, The Ohio State University, Columbus, OH, US|USA. (November 2010)

"Invariant NKT cells in pig lung: a potential asthma model." Presented at Center for Clinical and Translational Sciences, 2nd annual meeting, The Ohio State University, Columbus, OH, US|USA. (May 2011)

"Evaluation of immune responses to porcine reproductive and respiratory syndrome virus in pigs at day two post-infection." Presented at Conference Research Workers in Animal Diseases, Annual Meeting, Chicago, IL, US|USA. (December 2011)

"Evaluation of immune responses to porcine reproductive and respiratory syndrome virus in pigs at day two post-infection." Presented at International PRRS Symposium 2011, Chicago, IL, US|USA. (December 2011)

"Intranasal delivery of an adjuvanted modified live porcine reproductive and respiratory syndrome virus vaccine reduces the ROS induced lung pathology." Presented at International PRRS Symposium 2011, Chicago, IL, US|USA. (December 2011)

"Differential regulation of mucosal immune responses at various mucosal tissues in pigs infected with PRRSV strain VR2332." Presented at International PRRS Symposium 2011, Chicago, IL, US|USA. (December 2011)

"Differential regulation of mucosal immune responses at various mucosal tissues in pigs infected with PRRSV strain VR2332." Presented at Conference Research Workers in Animal Diseases, Annual Meeting, Chicago, IL, US|USA. (December 2011)

"Invariant NKT cells in pig lung: a potential asthma model." Presented at Center for Clinical and Translational Sciences, 2nd annual meeting, Columbus, OH, US|USA. (May 2011)

"Mucosal immunization with biodegradable PLG- nanoparticles elicits effective anti-PRRSV immune responses in Pigs." Presented at 98th Annual Meeting, The American Association of Immunologists, SanFrancisco, CA, US|USA. (May 2011)

"Nanoparticles entrapped killed PRRSV vaccine reduces PRRSV viremia in both homologous and heterologous PRRSV challenged pigs." Presented at Conference Research Workers in Animal Diseases, Annual Meeting, Chicago, IL, US|USA. (December 2011)

"Nanoparticles entrapped killed PRRSV vaccine reduces PRRSV viremia in both homologous and heterologous PRRSV challenged pigs." Presented at International PRRS Symposium 2011, Chicago, IL, US|USA. (December 2011)

"Intranasal delivery of an adjuvanted modified live porcine reproductive and respiratory syndrome virus vaccine reduces the ROS induced lung pathology." Presented at Conference Research Workers in Animal Diseases, Annual Meeting, Chicago, IL, US|USA. (December 2011)

"Development of swine oral fluid based porcine reproductive and respiratory syndrome virus neutralizing assay: a potential diagnostic tool for PRRS herd immunity." Presented at 93rd Annual Meeting of the Conference of Research Workers in Animal Diseases, Chicago, IL, US|USA. (December 2012)

"Effect of sample collection material on the detection of PRRSV in oral fluid." Presented at 93rd Annual Meeting of the Conference of Research Workers in Animal Diseases, Chicago, IL, US|USA. (December 2012)

"Development of croos-protective mucosal vaccines to control infectious respiratory viral diseases in a pig model." Presented at IAH&VB - Invited Presentation, Bengaluru, IN|IND. (April 2012)

"Suppression of CD8+ T cells function in pigs infected with swine influenza viruses." Presented at PHPID Annual Member Meeting, Columbus, OH, US|USA. (April 2012)

"World Veterinarians Day 2012; Significance and Importance." Presented at World Veterinarians Day 2012 - Invited Presentation, Hospet, IN|IND. (April 2012)

"Immune modulation at mucosal sites of pigs infected with a vaccine strain of PRRS virus." Presented at OARDC Annual Research Conference, Wooster, OH, US|USA. (April 2012)

"Immune modulation at mucosal sites of pigs infected with a vaccine strain of PRRS virus." Presented at PHPID Annual Member Meeting, Columbus, OH, US|USA. (April 2012)

"Nanoparticle-based killed adjuvanted porcine reproductive and respiratory syndrome virus vaccine elicits superior cross-protective immunity in pigs." Presented at OARDC Annual Research Conference, Wooster, OH, US|USA. (April 2012)

"Nanoparticle-based killed adjuvanted porcine reproductive and respiratory syndrome virus vaccine elicits superior cross-protective immunity in pigs." Presented at PHPID Annual Member Meeting, Columbus, OH, US|USA. (April 2012)

"Suppression of CD8+ T cells function in pigs infected with swine influenza viruses." Presented at Center for Clinical and Translational Sciences, 3rd annual meeting, Columbus, OH, US|USA. (May 2012)

"Nanoparticle-based adjuvanted inactivated porcine reproductive and respiratory syndrome virus vaccine elicits cross-protective immunity in pigs." Presented at 93rd Annual Meeting of the Conference of Research Workers in Animal Diseases, Chicago, IL, US|USA. (December 2012)

"Natural killer T cell adjuvanted inactivated swine influenza virus vaccine enhanced the viral load and suppressed the host immune response to pandemic 2009 H1N1 virus in pigs." Presented at 93rd Annual Meeting of the Conference of Research Workers in Animal Diseases, Chicago, IL, US|USA. (December 2012)

"Effect of sample collection material on the detection of PRRSV in oral fluid." Presented at 2012 International PRRS Symposium, Kansas City, MO, US|USA. (November 2012)

"Development of mucosal vaccines in pigs against porcine reproductive and respiratory syndrome." Presented at 6th International Veterinary Vaccines and Diagnostics Conference - Invited Presentation, Cairns, AU|AUS. (July 2012)

"Development of swine oral fluid based porcine reproductive and respiratory syndrome virus neutralizing assay: a potential diagnostic tool for PRRS herd immunity." Presented at 2012 International PRRS Symposium, Kansas City, MO, US|USA. (November 2012)

"Swine Oral Fluid Diagnostics Update." Presented at Proceedings of the 20th Annual Swine Disease Conference for Swine Practitioners, Ames, IA, US|USA. (November 2012)

"Nanoparticle-based adjuvanted inactivated porcine reproductive and respiratory syndrome virus vaccine elicits cross-protective immunity in pigs. 2012 International PRRS Symposium." Presented at 2012 International PRRS Symposium, Kansas City, MO, US|USA. (November 2012)

"Differential expression of DAP12 molecule and its associated receptors in the lungs of inactivated influenza virus vaccinated pigs challenged with a swine influenza virus." Presented at 94th Annual CWRAD meeting of the Conference of Research Workers in Animal Diseases, Chicago, IL, US|USA. (December 2013)

"Ethical issues in biomedical reserach and publciaitons." Presented at OARDC Research Internship Program - Invited Presentation, Wooster, OH, US|USA. (July 2013)

"Nanoparticle-based adjuvanted inactivated porcine reproductive and respiratory syndrome virus vaccine elicits cross-protective immunity in pigs." Presented at PHPID Annual Member Meeting, The Ohio State University, Columbus, OH, US|USA. (May 2013)

"Nanoparticle-based adjuvanted inactivated porcine reproductive and respiratory syndrome virus vaccine elicits cross-protective immunity in pigs." Presented at PHPID Annual Member Meeting, The Ohio State University, Columbus, OH, US|USA. (May 2013)

"Development and validation of an assay to detect porcine reproductive and respiratory syndrome virus specific neutralizing antibody titers in pig oral fluid samples." Presented at 2013 International porcine reproductive and respiratory syndrome symposium, Beijing, CN|CHN. (May 2013)

"Ethical issues in biomedical reserach and publciaitons." Presented at OARDC Scholars Workshop - Invited Presentation, Wooster, OH, US|USA. (March 2013)

"Development and validation of an assay to detect porcine reproductive and respiratory syndrome virus specific neutralizing antibody titers in pig oral fluid samples." Presented at 94th Annual CWRAD meeting of the Conference of Research Workers in Animal Diseases, Chicago, IL, US|USA. (December 2013)

"Natural killer T cell adjuvant-based inactivated swine influenza virus vaccine enhances the viral load and suppresses the host immune response to pandemic 2009 H1N1 influenza virus challenge in pigs." Presented at 100th Annual Meeting, The American Association of Immunologists, Honolulu, HI, US|USA. (May 2013)

"Effect of Streptococcus pneumoniae on influenza virus replication in epithelial cells." Presented at PHPID Annual Member Meeting, The Ohio State University, Columbus, OH, US|USA. (May 2013)

"Effect of Streptococcus pneumoniae on influenza virus replication in epithelial cells." Presented at PHPID Annual Member Meeting, The Ohio State University, Columbus, OH, US|USA. (May 2013)

"Development and validation of an assay to detect porcine reproductive and respiratory syndrome virus specific neutralizing antibody titers in pig oral fluid samples." Presented at PHPID Annual Member Meeting, The Ohio State University, Columbus, OH, US|USA. (May 2013)

"Development and validation of an assay to detect porcine reproductive and respiratory syndrome virus specific neutralizing antibody titers in pig oral fluid samples." Presented at PHPID Annual Member Meeting, The Ohio State University, Columbus, OH, US|USA. (May 2013)

"Natural killer T cell adjuvant-based inactivated swine influenza virus vaccine enhances the viral load and suppresses the host immune response to pandemic 2009 H1N1 influenza virus challenge in pigs." Presented at 16th International Congress of Mucosal Immunology, Vancouver, BC, CA|CAN. (July 2013)

"A New PRRS Vaccine: How does it work?." Presented at Swine Health Symposium - Invited Presentation, Plain City, US|USA. (June 2014)

"TREM2 differential expression is associated with BAL cells that express high levels of ARG-1." Presented at 101st Annual Meeting, The American Association of Immunologists, Pittsburg, PA, US|USA. (May 2014)

"Pretreatment of epithelial cells with live Streptococcus pneumoniae had no detectable effect on influenza A virus replication in vitro." Presented at 101st Annual Meeting, The American Association of Immunologists, Pittsburg, PA, US|USA. (May 2014)

"Nanotechnology based inactivated PRRS virus vaccine to induce cross-protective response in pigs." Presented at Exploring avian host and viral determinants of susceptibility to influenza virus infection - Invited Presentation, Compton, GB|GBR. (June 2014)

"PLGA nanoparticle-entrapped adjuvanted inactivated porcine reproductive and respiratory syndrome virus mucosal vaccine elicits cross-protective immunity in the respiratory tract of pigs." Presented at 101st Annual Meeting, The American Association of Immunologists, Pittsburg, PA, US|USA. (May 2014)

"Inhibition of Cd1d-medaited antigen presentation by the TGF-/Smad signaling pathway." Presented at 101st Annual Meeting, The American Association of Immunologists, Pittsburg, PA, US|USA. (May 2014)

"Nanotechnology based inactivated PRRS virus vaccine: a new hope to induce cross-protection in food animal species." Presented at International Symposium on Vaccines Against Antigenically Variable Viruses (VAAVV), sponsored by the consortium supported by Iowa State University’s Presidential Initiative for Interdisciplinary Research program - Invited Presentation, Ames. (June 2014)

"Comparative analysis of routes of immunization of a live PRRS virus vaccine in a heterologous virus challenge study." Presented at 95th Annual CWRAD meeting of the Conference of Research Workers in Animal Diseases, Chicago, IL, US|USA. (December 2014)

"Nanotechnology based inactivated virus vaccine to induce mucosal immunity in pigs." Presented at Plant Pathology seminar series - Invited Presentation, Wooster, OH, US|USA. (September 2014)

"Nanotechnology based viral vaccines: a new hope to induce cross-protection in a pig model." Presented at PHPID Work in Progress meeting - Invited Presentation, Columbus, OH, US|USA. (September 2014)

"Poly I:C adjuvanted inactivated swine influenza vaccine induces heterologous protective immunity in pigs." Presented at 95th Annual CWRAD meeting of the Conference of Research Workers in Animal Diseases, Chicago, IL, US|USA. (December 2014)

"Efficacy of M2e-based vaccine in Murine, Avian and Swine Models." Presented at 95th Annual CWRAD meeting of the Conference of Research Workers in Animal Diseases, Chicago, IL, US|USA. (December 2014)

"Production and evaluation of porcine reproductive and respiratory syndrome virus like particles in pigs." Presented at North American PRRS Symposium, Chicago, IL, US|USA. (December 2014)

"Comparative analysis of routes of immunization of a live PRRS virus vaccine in a heterologous virus challenge study." Presented at North American PRRS Symposium, Chicago, IL, US|USA. (December 2014)

"PLGA-Nanoparticle entrapped swine influenza virus peptides vaccine induces epitope specific cell-mediated immune response in pigs." Presented at 95th Annual CWRAD meeting of the Conference of Research Workers in Animal Diseases, Chicago, IL, US|USA. (December 2014)

"Nanotechnology based viral vaccines: A new hope to induce cross-protection in a pig model." Presented at Nanovaccine Initiative monthly webinar speaker - Invited Presentation, Ames. (October 2014)

"Nanovaccines against respiratory viruses." Presented at Nanovaccine Initiative Annual Meeting, sponsored by the consortium supported by Iowa State University’s Presidential Initiative for Interdisciplinary Research program - Invited Presentation, Ames. (August 2014)

"Viral antigen in nanoparticle induces strong immunity in pig lungs." Presented at Department of Animal Sciences seminar series - Invited Presentation, Ames. (March 2015)

"Comparative analysis of routes of immunization of a live PRRSV vaccine in a heterologous virus challenge study." Presented at Boehringer Ingelheim in-house meeting - Invited Presentation, Ames, Iowa. (March 2015)

"Evaluation of adjuvants to use with NanoPRRSV vaccine." Presented at American Association of Swine Veterinarians Symposium, a satellite meeting with Four Star Veterinary Animal Health Veterinarians - Invited Presentation, Orlando, FL, US|USA. (February 2015)

"Pig is a suitable animal model for influenza vaccine research. Faculty Seminar Series." Presented at Veterinary Medicine Faculty Seminar Series - Invited Presentation, Columbus, OH, US|USA. (March 2015)

"Nanoparticle entrapped swine influenza virus peptides vaccine induces epitope specific T cell response in pigs." Presented at Keystone Symposia: Immunity to Veterinary Pathogens: Informing Vaccine Development, Keystone, CO, US|USA. (January 2015)

"Nanoparticle based vaccine strategy against swine influenza virus." Presented at Nanovaccine Research Initiative, Ames, IA, US|USA. (May 2015)

"Vaccine studies to mitigate influenza in a pig model." Presented at Department of Biomedical Sciences seminar series - Invited Presentation, Ames. (March 2015)

"Nanoparticles encased conserved peptides of Influenza virus elicits cross-protective T cell response." Presented at Department of Veterinary Microbiology and Public Health seminar series, Bangalore, IN|IND. (May 2015)

"Swine flu vaccine." Presented at The Ohio State University, Technology commercialization office organized startup snapshot presentation - Invited Presentation, Columbus, OH, US|USA. (November 2015)

"Nanotechnology based viral vaccines: a novel strategy to elicit cross-protective response in pigs." Presented at Invited departmental presentation, Mittelhausern, CH|CHE. (August 2015)

"Nanotechnology based viral vaccines: a novel strategy to elicit cross-protective response in pigs." Presented at Fall 2015 Seminars, Kansas State University, Manhattan, KS, US|USA. (August 2015)

"A new strategy to elicit cross-protective immunity against respiratory virus infections in a pig model." Presented at Bortree Seminar Series at Pennsylvania State University - Invited Presentation, University Park, PA, US|USA. (February 2016)

"Biodegradable nanoparticle delivery of inactivated swine influenza virus vaccine provides heterologous protection through cell-mediated immunity in pigs." Presented at OARDC Research Conference, Wooster, OH, US|USA. (April 2016)

"Nanoparticle delivered inactivated swine influenza virus vaccine reduces the lung pathology in heterologous virus challenged pigs." Presented at OARDC Research Conference, Wooster, OH, US|USA. (April 2016)

 

Professional Activities

present February 2015, NIH study section member, Infectious Diseases and Microbiology: Research In Biomedicine and Agriculture. NIH.
present March 2016, NIH study section member, Infectious Diseases and Microbiology: Research In Biomedicine and Agriculture. NIH.
present March 2016, Biotechnology and Biological Sciences Research Council (BBSRC) - Study Section Member. BBSRC.
present March 2014, Biotechnology and Biological Sciences Research Council (BBSRC) - Study Section Member. BBSRC.
2013 - present Canadian Swine Health Board - Study Section Member.
2014 - present Ontario Pork Board, Canada - Study Section Member. Livestock Research Innovation Corporation.
2015 - present Treasurer of the OARDC community garden. The Ohio State University. Wooster, OH.
 

Technical Reports

Gourapura, RJ.. PRRS Immune Status to Improve Herd Immunity. : (January 0).

Gourapura, RJ.. Adjuvant improves response to PRRS vaccine. Minneapolis, MN, US|USA: National Hog Farmer. (December 2012).

Gourapura, RJ.. Mucosal route has potential against swine disease. London, GB|GBR: Animal Pharm – an online scientific bulletin by Dr. Philip Conolly. (January 2013).

Gourapura, RJ.. New vaccine to battle PRRS. : [A] Agriculture.com. (September 2013).

Gourapura, RJ.. Ohio State Researcher Develops New Vaccine for Swine Virus. : AG WEB. (October 2013).

 

Unpublished Works

Dhakal, S, J. Hiremath, K. Bondra, Y.S. Lakshmanappa, D. Shyu, K. Oyuang, K. Kang, B. Binjawadagi, J. Goodman, K. Tabynov, S. Krakowka, B. Narasimhan, C.W. Lee and Renukaradhya, G.J.. Biodegradable nanoparticle delivery of inactivated swine influenza virus vaccine provides heterologous protection through cell-mediated immunity in pigs. May 2016.

Dhakal, S, Manickam, C, Hiremath1, J, Binjawadagi1, B, Dwivedi, V, Ouyang, K, Shyu, D-L, and Renukaradhya, GJ.. Steps towards characterization of porcine myeloid derived suppressor cells. June 2016.