354 VMAB Veterinary Medicine Academic Building
1900 Coffey Rd
Columbus, OH 43210
Phone: (614) 247-4671
Email: boyaka.1@osu.edu
Current OSU Appointments
Professor, Pulm,Allergy,Crit Care & Sleep
Professor, Veterinary Biosciences
Advising
Doctoral Student (Dissertation Advisor)
| 1996 - 1998 | Salieu Abraham. An automated immunofluorescence microscopy system for the characterization of mucosally derived single cell immune responsesUniversity of Alabama, Birmingham, AL. Graduated: 1998. Current Position: Software development engineer, Scanalytic Inc., Fairfax, VA |
| 2001 - 2005 | Romy Fisher. Mouse models of peanut allergyContribution of oral and nasal sensitization to allergic reactions topeanut and cross-reactivity with food and environmental antigensUniversity of Alabama, Birmingham, AL. Graduated: 2005. Current Position: Assistant Professor, Institut National Agronomique, Paris, France Noteworthy Accomplishments: 1. Demonstrated the influence of the initial mucosal site of allergen sensitization in subsequent allergic responses 2. Established a new mouse model for evaluation of allergy in mucosal tissue3. Won a prestigeous scholarship by the French Ministry of Education (2001-2004) |
| 2003 - 2007 | Alexandra Duverger. Regulation of mucosal immune responses by anthrax edema toxin derivatives. The Ohio State University, Columbus, OH. Graduated: . Current Position: Postdoctoral fellow, The University of Alabama at Birmingham Noteworthy Accomplishments: Identified anthrax toxin receptors as new target for mucosal adjuvants |
Masters Student Plan B (Advisor)
| 2004 - 2005 | Cecilia Vuillard. University of Alabama, Birmingham, AL. Graduated: 2005. Current Position: Medical student |
| 2005 - 2006 | Elodie Muraz. University of Alabama, Birmingham, AL. Graduated: 2006. Current Position: PhD candidate |
| 2005 - 2006 | Edith Crenn. University of Alabama, Birmingham, AL. Graduated: 2006. Current Position: PhD candidate |
| 2006 - 2007 | Chloe Manificat. Institut National Agronomique Paris-Grignon, Paris, Graduated: 2007. Current Position: MBA student |
| 2006 - 2007 | Juliette Trepreau. Institut National Agronomique Paris-Grignon, Paris, Graduated: 2007. Current Position: PhD candidate |
| 2007 - 2008 | Jeanne-Marie Carre. AgroParisTech, Paris, Graduated: 2008. Current Position: PhD candidate |
| 2008 - 2009 | Xavier Duportet. AgroParisTech, Paris, Graduated: 2009. |
| 2008 - 2009 | Igor Stzepourginski. AgroParisTech, Paris, Graduated: 2009. |
| 2009 - present | Caroline Desclée de Maredsous. AgroParisTech, Paris, |
| 2009 - present | Morgane Thierry-Mieg. AgroParisTech, Paris, |
Postdoctoral (Advisor)
| 2002 - 2005 | Angela Tafaro. University of Alabama, Birmingham, AL. Current Position: Instructor, University of Bari, Bari, Italy Noteworthy Accomplishments: Developped chimera of enterotoxins that were crucial for elucidating some of the mechanisms underlying the adjuvant activity of these molecules |
| 2007 - 2008 | Sanjay Singh. The Ohio State University, Columbus, OH. Current Position: Instructor, East Tennessee State University |
Chapters In Books
Fujihashi, K., S. Yamamoto, M. Marinaro, M. Kweon, J.L. VanCott, M. Yamamoto, K. Imaoka, P.N. Boyaka, F.W. van Ginkel, H. Kurazono, R.J. Jackson, H. Kiyono and J.R. McGhee. 1996. Regulation of mucosal immune responses by helper T cells and cytokines. In Inflammatory Bowel Diseases and Chronic Recurrent Abdominal Pain. Edited by Hadziselimovic F. and B. Herzog,. Dordrecht, Germany: Kluwer Academic Publishers. 62-82.
Kiyono, H., K. Fujihashi, M. Yamamoto, T. Hiroi, M. Coste, S. Kawabata, P.N. Boyaka and J.R. McGhee. 1996. Intraepithelial gd T cells and epithelial cell interactions in the mucosal immune system. In Essential of Mucosal Immunology. Edited by M.F. Kagnoff and H. Kiyono. San Diego, CA, USA: Academic Press. 195-205.
Boyaka, P.N., J.W. Lillard, Jr., S. Yamamoto and J.R. McGhee. 1999. Mutant enterotoxins and mucosally administered cytokines for safe targeting of Th1- and Th2-type responses by mucosal adjuvants. In Induction and Modulation of Gastrointestinal Inflammation. Dordrecht, Germany: Kluwer Academic Publishers. 81-93.
Boyaka, P.N., M. Marinaro, K. Fujihashi, and J.R. McGhe. 2001. Host defense at mucosal surfaces. In Clinical Immunology. 2nd ed. Edited by R.R. Rich, T.A. Fleisher, W.T. Shearer, B.L. Kotzin, H.W. Schroeder Jr. London, UK: Mosby International Limited. 20.1-20.18.
Boyaka, P.N., and J.R. McGhee. 2002. Immune defense at mucosal surfaces. In Immunotherapy for Infectious Diseases.. Edited by J.M. Jacobson. Amsterdam, Netherlands: Humana Press. 39-60.
Boyaka, P.N., J.R. McGhee, C. Czerkinsky, and M. Mestecky. 2005. Mucosal vaccines: an overview. In Mucosal Immunology. 3rd ed. Edited by Mestecky, J., Bienenstock, J., Lamm, M., Mayer, L., Mcghee, J.R., and Strober, W. Amsterdam, Netherlands: Academic Press. 855-874.
Fujihashi, K., P.N. Boyaka, and J.R McGhee. 2005. . Mucosal immune responses. In Microbiology and Microbial Infections. Edited by S.H.E. Kaufmann. London, UK: Edward Arnold Limited. 519-555.
Boyaka PN., A. Duverger, E. Cormet-Boyaka, and J.-N. Tournier. 2008. Mucosal immunity against anthrax. In Immunity against mucosal pathogens. Edited by M Vajdy. Amsterdam, Netherland: Springer Science. 367-381.
Fujihashi, K., P.N. Boyaka, and J.R. McGhe. 2008. Mucosal immune responses. In Clinical Immunology. 3rd ed. Edited by R.R. Rich, T.A. Fleisher, W.T. Shearer, H.W. Schroeder Jr., A.J. Frew, CM. Weyand. London, UK: Mosby International Limited. 287-303.
Degrees
| 1989 | M.S., University Paris 7, Dennis Diderot, Biochemistry |
| 1994 | Ph.D., University Paris 7, Dennis Diderot, Toxicology- Immunotoxicology |
Editorial Activities
Journal Ad Hoc Reviewer
| 2008 - present | Mucosal Immunology. (Manuscript) |
| 2006 - present | Immunity. (Manuscript) |
| 2005 - present | The Journal of Immunology. (Manuscript) |
| 2005 - present | Proceeding of the national academy of sciences (PNAS). (Manuscript) |
| 2004 - present | Microbes and Infection. (Manuscript) |
| 2002 - present | Vaccine. (Manuscript) |
Journal Associate Editor
| 2005 - present | Current Immunology Reviews. (Review) |
| 2001 - 2005 | The Journal of Immunology. (Manuscript) |
| 2000 - 2002 | Infection and Immunity. (Manuscript) |
Fellowship, Internship or Residency
| 1995 - 1998 | Postdoctoral, Mucosal Immunology, University of Alabama, Birmingham, AL, United States. |
Languages
French: (ability to read: Fluent, ability to write: Fluent, ability to speak: Fluent)
Memberships
| 1998 - present | Member. American Association of Immunologists |
| 1999 - present | Member. Society for Mucosal Immunology |
| 1999 - present | Member. American Society of Microbiology |
| 2006 - 2009 | Member. The American Association of Immunologist. Minority Affair Committee |
| 2009 - 2011 | Program Chair. The American Association of Immunologist. Mucosal and Regional Immunology |
Peer Reviewed Journal Articles
BOYAKA, P; COSTE, M; ROCHET, V; TOME D. 1991. Effect Of Neuraminidase Treatment Of The Proliferative Response Of Rat Intestinal Intraepithelial Lymphocytes. Gastroenterology. Vol. 100, no. 5 PART 2: A564.
Coste, M.; Boyaka, P. N.; Dubarry, M.; Tome, D. 1993. Desialation of intraepithelial lymphocytes: Relation with cell proliferation and gamma-interferon production. FASEB Journal. Vol. 7, no. 3-4: A369.
Coste, M.; Boyaka, P. N.; Dubarry, M.; Tome, D. 1993. Differential susceptibility of Iels and spleen cells to bacterial neuraminidase in rats. Gastroenterology. Vol. 104, no. 4 SUPPL.: A686.
Portier, A.; Boyaka, N. P.; Bougoudogo, F.; Dubarry, M.; Huneau, J. F.; Tome, D.; Dodin, A.; Coste, M. 1993. Fermented milks and increased antibody responses against cholera in mice. International Journal of Immunotherapy. Vol. 9, no. 4: 217-224.
Boyaka, P. N.; Dubarry, M.; Rautureau, M.; Coste, M.; Tome, D. 1994. Differential susceptibility of Caco-2 cell enzymatic activities to Clostridium perfringens neuraminidase. FASEB Journal. Vol. 8, no. 4-5: A17.
Boyaka, P, N; Coste, M; Tome, D. 1995. Desialylation of rat intraepithelial lymphocytes: effects on proliferation and dipeptidyl peptidase IV activity. Advances in experimental medicine and biology. Vol. 371A: 133-6.
Marinaro, M; Staats, H, F; Hiroi, T; Jackson, R, J; Coste, M; Boyaka, P, N; Okahashi, N; Yamamoto, M; Kiyono, H; Bluethmann, H; Fujihashi, K; McGhee, J R. 1995. Mucosal adjuvant effect of cholera toxin in mice results from induction of T helper 2 (Th2) cells and IL-4. Journal of immunology (Baltimore, Md. : 1950). Vol. 155, no. 10: 4621-9.
Boyaka, P. N.; Fujihashi, K.; McGhee, J. R.; Kawabata, S.; Kiyono, H. 1996. Tip and crypt intestinal epithelial cells express different levels of Cd80 and Cd86 molecules. FASEB Journal. Vol. 6: A1363.
Boyaka, P. N.; Fujihashi, K.; McGhee, J. R.; Kawabata, S.; Kiyono, H. 1996. Tip and crypt intestinal epithelial cells express different levels of Cd80 and Cd86 molecules. FASEB Journal. Vol. 10, no. 6: A1363.
Marinaro, M.; Boyaka, P. N.; Jackson, R. J.; Finkelman, F. D.; Gately, M. K.; Kiyono, H.; McGhee, J. R. 1996. Mucosal administration of rmil-12 to mice modulates Th2-type responses induced by an oral vaccine. FASEB Journal. Vol. 10, no. 6: A1036.
Marinaro, M; Boyaka, P, N; Jackson, R, J; Finkelman, F, D; Kiyono, H; McGhee, J R. 1996. Interleukin-12 alters helper T-cell subsets and antibody profiles induced by the mucosal adjuvant cholera toxin. Annals of the New York Academy of Sciences. Vol. 795: 361-5.
Yamamoto, M.; McGhee, J. R.; Kurazono, H.; Shimpuku, Y.; Boyaka, P. N.; Marinaro, M.; Jackson, R. J.; Kiyono, H. 1996. Effect of Lt on mucosal immune responses in Il-4 knockout mice. FASEB Journal. Vol. 10, no. 6: A1190.
Boyaka, P. N.; Jackson, R. J.; Marinaro, M.; Vanginkel, F. W.; Kiyono, H.; McGhee, J. R. 1997. Orally delivered saponin-derived Qs-21 adjuvant elicits systemic and mucosal antibody responses to co-administered protein antigen. Journal of Allergy and Clinical Immunology. Vol. 99, no. 1 PART 2: S35.
Kawabata, S; Boyaka, P, N; Coste, M; Fujihashi, K; Hamada, S; McGhee, J, R; Kiyono, H. 1997. A novel alkaline phosphatase-based isolation method allows characterization of intraepithelial lymphocytes from villi tip and crypt regions of murine small intestine. Biochemical and biophysical research communications. Vol. 241, no. 3: 797-802.
Kawabata, Shigetada; Boyaka, Prosper N.; Coste, Michel; Fujihashi, Kohtaro; Hamada, Shigeyuki; McGhee, Jerry R.; Kiyono, Hiroshi. 1997. A novel alkaline phosphatase-based isolation method allows characterization of intraepithelial lymphocytes from villi tip and crypt regions of murine small intestine. Biochemical and Biophysical Research Communications. Vol. 241, no. 3: 797-802.
Marinaro, M.; Boyaka, P. N.; Jackson, R. J.; Finkelman, F. D.; Kiyono, H.; McGhee, J. R. 1997. Intranasal Il-12 delivery enhances Th2-type while oral Il-12 redirects Th2- to Th1-type responses. Journal of Allergy and Clinical Immunology. Vol. 99, no. 1 PART 2: S34.
Marinaro, M; Boyaka, P, N; Finkelman, F, D; Kiyono, H; Jackson, R, J; Jirillo, E; McGhee, J R. 1997. Oral but not parenteral interleukin (IL)-12 redirects T helper 2 (Th2)-type responses to an oral vaccine without altering mucosal IgA responses. The Journal of experimental medicine. Vol. 185, no. 3: 415-27.
Marinaro, Mariarosaria; Boyaka, Prosper N.; Finkelman, Fred D.; Kiyono, Hiroshi; Jackson, Raymond J.; Jirillo, Emilio; McGhee, Jerry R. 1997. Oral but not parenteral interleukin (il)-12 redirects T helper 2 (th2)-type responses to an oral vaccine without altering mucosal Iga responses. Journal of Experimental Medicine. Vol. 185, no. 3: 415-427.
Pascual, D, W; Coste, M; Boyaka, P, N; Kiyono, H; McGhee, J R. 1997. Spontaneously hypertensive rat: cholera toxin converts suppression to immunity through a Th2 cell-IL-4 pathway. The American journal of physiology. Vol. 273, no. 4 Pt 2: R1509-18.
Pascual, David W.; Coste, Michel; Boyaka, Prosper N.; Kiyono, Hiroshi; McGhee, Jerry R. 1997. Spontaneously hypertensive rat: Cholera toxin converts suppression to immunity through a Th2 cell-il-4 pathway. American Journal of Physiology. Vol. 273, no. 4 PART 2: R1509-R1518.
Cormet-Boyaka, E; Huneau, J, F; Mordrelle, A; Boyaka, P, N; Carbon, C; Rubinstein, E; Tome, D. 1998. Secretion of sparfloxacin from the human intestinal Caco-2 cell line is altered by P-glycoprotein inhibitors. Antimicrobial agents and chemotherapy. Vol. 42, no. 10: 2607-11.
Cormet-Boyaka, Estelle; Huneau, Jean-Francois; Mordrelle, Agnes; Boyaka, Prosper N.; Carbon, Claude; Rubinstein, Ethan; Tome, Daniel. 1998. Secretion of sparfloxacin from the human intestinal Caco-2 cell line is altered by P-glycoprotein inhibitors. Antimicrobial Agents and Chemotherapy. Vol. 42, no. 10: 2607-2611.
Kawabata, S; Boyaka, P, N; Coste, M; Fujihashi, K; Yamamoto, M; McGhee, J, R; Kiyono, H. 1998. Intraepithelial lymphocytes from villus tip and crypt portions of the murine small intestine show distinct characteristics. Gastroenterology. Vol. 115, no. 4: 866-73.
Kawabata, Shigetada; Boyaka, Prosper N.; Coste, Michel; Fujihashi, Kohtaro; Yamamoto, Masafumi; McGhee, Jerry R.; Kiyono, Hiroshi. 1998. Intraepithelial lymphocytes from villus tip and crypt portions of the murine small intestine show distinct characteristics. Gastroenterology. Vol. 115, no. 4: 866-873.
Lillard, J. W., Jr.; Boyaka, P. N.; Kweon, M.; Yamamoto, M.; Yamamoto, S.; Chertov, O.; Oppenheim, J. J. 1998. Mucosal administration of defensins with antigen induces Th1- and Il-4 independent-th2 type responses. FASEB Journal. Vol. 12, no. 5: A909.
Nguyen, H, H; Boyaka, P, N; Moldoveanu, Z; Novak, M, J; Kiyono, H; McGhee, J, R; Mestecky, J. 1998. Influenza virus-infected epithelial cells present viral antigens to antigen-specific CD8+ cytotoxic T lymphocytes. Journal of virology. Vol. 72, no. 5: 4534-6.
Nguyen, Huan H.; Boyaka, Prosper N.; Moldoveanu, Zina; Novak, Miroslav J.; Kiyono, Hiroshi; McGhee, Jerry R.; Mestecky, Jiri. 1998. Influenza virus-infected epithelial cells present viral antigens to antigen-specific Cd8+ cytotoxic T lymphocytes. Journal of Virology. Vol. 72, no. 5: 4534-4536.
Boyaka, P, N; Lillard, J W Jr; McGhee, J. 1999. Interleukin 12 and innate molecules for enhanced mucosal immunity. Immunologic research. Vol. 20, no. 3: 207-17.
Boyaka, P, N; Marinaro, M; Jackson, R, J; Menon, S; Kiyono, H; Jirillo, E; McGhee, J R. 1999. IL-12 is an effective adjuvant for induction of mucosal immunity. Journal of immunology (Baltimore, Md. : 1950). Vol. 162, no. 1: 122-8.
Boyaka, P, N; Marinaro, M; Vancott, J, L; Takahashi, I; Fujihashi, K; Yamamoto, M; van Ginkel, F, W; Jackson, R, J; Kiyono, H; McGhee, J R. 1999. Strategies for mucosal vaccine development. The American journal of tropical medicine and hygiene. Vol. 60, no. 4 Suppl: 35-45.
Boyaka, P. N.; Lillard, J. W., Jr.; Jackson, R. J.; van Ginkel, F. W.; Marinaro, M.; Kiyono, H.; McGhee, J. R. 1999. Endogenous Il-12 regulates mucosal immune responses. Immunology Letters. Vol. 69, no. 1: 75.
Boyaka, Prosper N.; Lillard, James W., Jr.; McGhee, Jerry. 1999. Interleukin 12 and innate molecules for enhanced mucosal immunity. Immunologic Research. Vol. 20, no. 3: 207-217.
Boyaka, Prosper N.; Marinaro, Mariarosaria; Vancott, John L.; Takahashi, Ichiro; Fujihashi, Kohtaro; Yamamoto, Masafumi; Van Ginkel, Frederik W.; Jackson, Raymond J.; Kiyono, Hiroshi; McGhee, Jerry R. 1999. Strategies for mucosal vaccine development. American Journal of Tropical Medicine and Hygiene. Vol. 60, no. 4 SUPPL.: 35-45.
Lillard, J W Jr; Boyaka, P, N; Chertov, O; Oppenheim, J, J; McGhee, J R. 1999. Mechanisms for induction of acquired host immunity by neutrophil peptide defensins. Proceedings of the National Academy of Sciences of the United States of America. Vol. 96, no. 2: 651-6.
Lillard, J W Jr; Boyaka, P, N; Hedrick, J, A; Zlotnik, A; McGhee, J R. 1999. Lymphotactin acts as an innate mucosal adjuvant. Journal of immunology (Baltimore, Md. : 1950). Vol. 162, no. 4: 1959-65.
Lillard, J. W., Jr.; Boyaka, P. N.; McGhee, J. R. 1999. Links between innate and adaptive immunity. Immunology Letters. Vol. 69, no. 1: 75.
Lillard, James W., Jr.; Boyaka, Prosper N.; Chertov, Oleg; Oppenheim, Joost J.; McGhee, Jerry R. 1999. Mechanisms for induction of acquired host immunity by neutrophil peptide defensins. Proceedings of the National Academy of Sciences of the United States of America. Vol. 96, no. 2: 651-656.
Marinaro, M.; Boyaka, P. N.; Jackson, R. J.; Kiyono, H.; McGhee, J. R. 1999. Mucosal administration of Il-12 to target Th1- or Th2-type responses to mucosal vaccines. Immunology Letters. Vol. 69, no. 1: 92-93.
Marinaro, M; Boyaka, P, N; Jackson, R, J; Finkelman, F, D; Kiyono, H; Jirillo, E; McGhee, J R. 1999. Use of intranasal IL-12 to target predominantly Th1 responses to nasal and Th2 responses to oral vaccines given with cholera toxin. Journal of immunology (Baltimore, Md. : 1950). Vol. 162, no. 1: 114-21.
Boyaka, P, N; Wright, P, F; Marinaro, M; Kiyono, H; Johnson, J, E; Gonzales, R, A; Ikizler, M, R; Werkhaven, J, A; Jackson, R, J; Fujihashi, K; Di Fabio, S; Staats, H, F; McGhee, J R. 2000. Human nasopharyngeal-associated lymphoreticular tissues. Functional analysis of subepithelial and intraepithelial B and T cells from adenoids and tonsils. The American journal of pathology. Vol. 157, no. 6: 2023-35.
Boyaka, P. N.; Lillard, J. W., Jr.; Mestecky, J.; McGhee, J. R. 2000. Impaired mucosal immunity in Il-12 knockout mice. FASEB Journal. Vol. 14, no. 6: A1247.
Boyaka, P. N.; Zagury, D.; Jackson, R. J.; Kiyono, H.; McGhee, J. R. 2000. Hiv Tat protein regulation of mucosal immunity. Journal of Human Virology. Vol. 3, no. 5: 257.
Boyaka, Prosper N.; Wright, Peter F.; Marinaro, Mariarosaria; Kiyono, Hiroshi; Johnson, Joyce E.; Gonzales, Ricardo A.; Ikizler, Mine R.; Werkhaven, Jay A.; Jackson, Raymond J.; Fujihashi, Kohtaro; Di Fabio, Simonetta; Staats, Herman F.; McGhee, Jerry R. 2000. Human nasopharyngeal-associated lymphoreticular tissues: Functional analysis of subepithelial and intraepithelial B and T cells from adenoids and tonsils. American Journal of Pathology. Vol. 157, no. 6: 2023-2035.
Lillard, J. W., Jr.; Boyaka, P. N.; Taub, D. D.; McGhee, J. R. 2000. Rantes potentiates acquired mucosal immunity. FASEB Journal. Vol. 14, no. 6: A1204.
Naren, A, P; Di, A; Cormet-Boyaka, E; Boyaka, P, N; McGhee, J, R; Zhou, W; Akagawa, K; Fujiwara, T; Thome, U; Engelhardt, J, F; Nelson, D, J; Kirk, K L. 2000. Syntaxin 1A is expressed in airway epithelial cells, where it modulates CFTR Cl(-) currents. The Journal of clinical investigation. Vol. 105, no. 3: 377-86.
Naren, Anjaparavanda P.; Di, Anke; Cormet-Boyaka, Estelle; Boyaka, Prosper N.; McGhee, Jerry R.; Zhou, Weihong; Akagawa, Kimio; Fujiwara, Tomonori; Thome, Ulrich; Engelhardt, John F.; Nelson, Deborah J.; Kirk, Kevin L. 2000. Syntaxin 1a is expressed in airway epithelial cells, where it modulates Cftr Cl- currents. Journal of Clinical Investigation. Vol. 105, no. 3: 377-386.
Boyaka, P, N; Marinaro, M; Jackson, R, J; van Ginkel, F, W; Cormet-Boyaka, E; Kirk, K, L; Kensil, C, R; McGhee, J R. 2001. Oral QS-21 requires early IL-4 help for induction of mucosal and systemic immunity. Journal of immunology (Baltimore, Md. : 1950). Vol. 166, no. 4: 2283-90. (IF: 6)
Boyaka, P, N; McGhee, J R. 2001. Cytokines as adjuvants for the induction of mucosal immunity. Advanced drug delivery reviews. Vol. 51, no. 1-3: 71-9.
Boyaka, Prosper N.; Lillard, James W., Jr.; Jackson, Raymond J.; McGhee, Jerry R. 2001. Th1 cell regulation of mucosal Iga responses. FASEB Journal. Vol. 15, no. 5: A1043.
Boyaka, Prosper N.; McGhee, Jerry R. 2001. Cytokines as adjuvants for the induction of mucosal immunity. Advanced Drug Delivery Reviews. Vol. 51, no. 1-3: 71-79.
Etani, Yuri; McGhee, Jerry R.; Koga, Toshiya; Boyaka, Prosper N.; Fujihashi, Kohtaro. 2001. Impaired mucosal Th1-type immune responses in aged mice. FASEB Journal. Vol. 15, no. 4: A365.
Fujihashi, K; Kato, H; van Ginkel, F, W; Koga, T; Boyaka, P, N; Jackson, R, J; Kato, R; Hagiwara, Y; Etani, Y; Goma, I; Fujihashi, K; Kiyono, H; McGhee, J R. 2001. A revisit of mucosal IgA immunity and oral tolerance. Acta odontologica Scandinavica. Vol. 59, no. 5: 301-8.
Fujihashi, Kohtaro; Kato, Hirotomo; van Ginkel, Frederik W.; Koga, Toshiya; Boyaka, Prosper N.; Jackson, Raymond J.; Kato, Rie; Hagiwara, Yukari; Etani, Yuri; Goma, Iwao; Fujihashi, Keiko; Kiyono, Hiroshi; McGhee, Jerry R. 2001. A revisit of mucosal Iga immunity and oral tolerance. Acta Odontologica Scandinavica. Vol. 59, no. 5: 301-308.
Jackson, Raymond J.; Boyaka, Prosper N.; van Ginkel, Frederik W.; Kensil, Charlotte R.; Mcghee, Jerry R. 2001. Intranasal immunization with Type 3 polysaccharide and Qs-21 or Qs-7 affords protection in mice challenged with S. pneumoniae by the respiratory route. FASEB Journal. Vol. 15, no. 5: A1189.
Lillard, J W Jr; Boyaka, P, N; Singh, S; McGhee, J R. 2001. Salmonella-mediated mucosal cell-mediated immunity. Cellular and molecular biology (Noisy-le-Grand, France). Vol. 47, no. 7: 1115-20.
Lillard, J W Jr; Boyaka, P, N; Taub, D, D; McGhee, J R. 2001. RANTES potentiates antigen-specific mucosal immune responses. Journal of immunology (Baltimore, Md. : 1950). Vol. 166, no. 1: 162-9.
Lillard, James W., Jr.; Boyaka, Prosper N.; Singh, Shailesh; McGhee, Jerry R. 2001. Salmonella-mediated mucosal cell-mediated immunity. Cellular and Molecular Biology (Noisy-Le-Grand). Vol. 47, no. 7: 1115-1120.
Ben Nasser, Imed; Boyaka, Prosper N.; Ben Aissa, Fatma Fennira; Jeddi, Moncef; Tome, Daniel. 2003. The (173-196) fragment of ovalbumin suppresses ovalbumin-specific rat Ige responses. International Immunopharmacology. Vol. 3, no. 12: 1569-1579.
Ben Nasser, Imed; Boyaka, Prosper, N; Fennira Ben Aissa, Fatma; Jeddi, Moncef; Tome, Daniel. 2003. The [173-196] fragment of ovalbumin suppresses ovalbumin-specific rat IgE responses. International immunopharmacology. Vol. 3, no. 12: 1569-79.
Boyaka, Prosper N.; Ohmura, Mari; Fujihashi, Kohtaro; Koga, Toshiya; Yamamoto, Masafumi; Kweon, Mi-Na; Takeda, Yoshifumi; Jackson, Raymond J.; Kiyono, Hiroshi; Yuki, Yoshikazu; McGhee, Jerry R. 2003. Chimeras of labile toxin one and cholera toxin retain mucosal adjuvanticity and direct Th cell subsets via their B subunit. Journal of Immunology. Vol. 170, no. 1: 454-462.
Boyaka, Prosper N.; Tafaro, Angela; Fischer, Romy; Fujihashi, Kohtaro; Jirillo, Emilio; McGhee, Jerry R. 2003. Therapeutic manipulation of the immune system: Enhancement of innate and adaptive mucosal immunity. Current Pharmaceutical Design. Vol. 9, no. 24: 1965-1972.
Boyaka, Prosper N.; Tafaro, Angela; Fischer, Romy; Leppla, Stephen H.; Fujihashi, Kohtaro; McGhee, Jerry R. 2003. Effective mucosal immunity to anthrax: Neutralizing antibodies and Th cell responses following nasal immunization with protective antigen. Journal of Immunology. Vol. 170, no. 11: 5636-5643.
Boyaka, Prosper N.; Tafaro, Angela; Fischer, Romy; Leppla, Stephen H.; Jackson, Raymond J.; Fujihashi, Kohtaro; McGhee, Jerry R. 2003. Neutralizing antibodies and T helper cell responses following nasal immunization with anthrax protective antigen. FASEB Journal. Vol. 17, no. 7: C320.
Boyaka, Prosper, N; Ohmura, Mari; Fujihashi, Kohtaro; Koga, Toshiya; Yamamoto, Masafumi; Kweon, Mi-Na; Takeda, Yoshifumi; Jackson, Raymond, J; Kiyono, Hiroshi; Yuki, Yoshikazu; McGhee, Jerry R. 2003. Chimeras of labile toxin one and cholera toxin retain mucosal adjuvanticity and direct Th cell subsets via their B subunit. Journal of immunology (Baltimore, Md. : 1950). Vol. 170, no. 1: 454-62.
Boyaka, Prosper, N; Tafaro, Angela; Fischer, Romy; Fujihashi, Kohtaro; Jirillo, Emilio; McGhee, Jerry R. 2003. Therapeutic manipulation of the immune system: enhancement of innate and adaptive mucosal immunity. Current pharmaceutical design. Vol. 9, no. 24: 1965-72.
Boyaka, Prosper, N; Tafaro, Angela; Fischer, Romy; Leppla, Stephen, H; Fujihashi, Kohtaro; McGhee, Jerry R. 2003. Effective mucosal immunity to anthrax: neutralizing antibodies and Th cell responses following nasal immunization with protective antigen. Journal of immunology (Baltimore, Md. : 1950). Vol. 170, no. 11: 5636-43.
Fischer, Romy; McGhee, Jerry R.; Vu, Huong L.; Jackson, Raymond J.; Tome, Daniel; Boyaka, Prosper N. 2003. Airway inflammation and cytokine responses in mouse models of peanut allergy. FASEB Journal. Vol. 17, no. 7: C249-C250.
Jackson, Raymond John; van Ginkel, Frederik W.; Boyaka, Prosper N.; McGhee, Jerry R. 2003. A link between upregulation of nerve growth factor and cholera toxin adjuvanticity. FASEB Journal. Vol. 17, no. 7: C232.
Lillard, James W Jr; Singh, Udai, P; Boyaka, Prosper, N; Singh, Shailesh; Taub, Dennis, D; McGhee, Jerry R. 2003. MIP-1alpha and MIP-1beta differentially mediate mucosal and systemic adaptive immunity. Blood. Vol. 101, no. 3: 807-14.
Lillard, James W., Jr.; Singh, Udai P.; Boyaka, Prosper N.; Singh, Shailesh; Taub, Dennis D.; McGhee, Jerry R. 2003. Mip-1alpha and Mip-1beta differentially mediate mucosal and systemic adaptive immunity. Blood. Vol. 101, no. 3: 807-814.
Tafaro, Angela; McGhee, Jerry R.; Fischer, Romy; Jackson, Raymond J.; Leppla, Stephen H.; Boyaka, Prosper N. 2003. Protective immunity to a combined spore and protective antigen nasal anthrax vaccine. FASEB Journal. Vol. 17, no. 7: C324.
Sfeir, Rose Mary; Dubarry, Michel; Boyaka, Prosper, N; Rautureau, Michele; Tome, Daniel. 2004. The mode of oral bovine lactoferrin administration influences mucosal and systemic immune responses in mice. The Journal of nutrition. Vol. 134, no. 2: 403-9.
Singh, Udai P.; Singh, Shailesh; Boyaka, Prosper N.; McGhee, Jerry R.; Lillard, James W. Jr. 2004. Granulocyte chemotactic protein-2 mediates adaptive immunity in part through Il-8rbeta interactions. Journal of Leukocyte Biology. Vol. 76, no. 6: 1240-1247.
Singh, Udai, P; Singh, Shailesh; Boyaka, Prosper, N; McGhee, Jerry, R; Lillard, James W Jr. 2004. Granulocyte chemotactic protein-2 mediates adaptive immunity in part through IL-8Rbeta interactions. Journal of leukocyte biology. Vol. 76, no. 6: 1240-7.
Ben Nasser, Imed; Fennira-ben Aissa, Fatma; Boyaka, Prosper N.; Jeddi, Moncef; Tome, Daniel. 2005. Prior exposure to the carrier regulates rat immune responses to a conjugate vaccine. International Immunopharmacology. Vol. 5, no. 11: 1633-1640.
Ben Nasser, Imed; Fennira-Ben Aissa, Fatma; Boyaka, Prosper, N; Jeddi, Moncef; Tome, Daniel. 2005. Prior exposure to the carrier regulates rat immune responses to a conjugate vaccine. International immunopharmacology. Vol. 5, no. 11: 1633-40.
Fischer, Romy; McGhee, Jerry R.; Vu, Huong Lan; Atkinson, T. Prescott; Jackson, Raymond J.; Tome, Daniel; Boyaka, Prosper N. 2005. Oral and nasal sensitization promote distinct immune responses and lung reactivity in a mouse model of peanut allergy. American Journal of Pathology. Vol. 167, no. 6: 1621-1630.
Lifrani, Awatif; Dubarry, Michel; Rautureau, Michele; Aattouri, Najat; Boyaka, Prosper N.; Tome, Daniel. 2005. Peanut-lupine antibody cross-reactivity is not associated to cross-allergenicity in peanut-sensitized mouse strains. International Immunopharmacology. Vol. 5, no. 9: 1427-1435.
Boyaka, Prosper N.; Duverger, Alexandra; Tang, Wei-Jen; Fujihashi, Kohtaro; McGhee, Jerry R.; Leppla, Stephen H. 2006. A novel method for delivery of regulatory molecules in the Gi tract using Bacillus anthracis protective antigen. Journal of Immunology. Vol. 176, no. Suppl. S: S243.
Duverger, Alexandra; Jackson, Raymond J.; van Ginkel, Frederick W.; Fischer, Romy; Tafaro, Angela; Leppla, Stephen H.; Fujihashi, Kohtaro; Kiyono, Hiroshi; McGhee, Jerry R.; Boyaka, Prosper N. 2006. Bacillus anthracis edema toxin acts as an adjuvant for mucosal immune responses to nasally administered vaccine antigens. Journal of Immunology. Vol. 176, no. 3: 1776-1783.
Duverger, Alexandra; Leppla, Stephen H.; Tang, Wei-Jen; Fujihashi, Kohtaro; Kiyono, Hiroshi; Mcghee, Jerry R.; Boyaka, Prosper N. 2006. Bacillus anthracis edema toxin acts as an adjuvant for enhanced immunity to Pa and to unrelated vaccine antigens co-administered by the nasal or the transcutaneous route. Journal of Immunology. Vol. 176, no. Suppl. S: S115.
Fischer, Romy; Debbabi, Hajer; Dubarry, Michel; Boyaka, Prosper; Tome, Daniel. 2006. Regulation of physiological and pathological Th1 and Th2 responses by lactoferrin. Biochemistry and Cell Biology. Vol. 84, no. 3: 303-311.
Fischer, Romy; Tome, Daniel; Boyaka, Prosper N. 2006. Th1 and Th2 cells are both required in mice eosinophil- and neutrophil-associated asthma models. FASEB Journal. Vol. 20, no. 4, Part 1: A212-A213.
Hagiwara, Yukari; Kawamura, Yuki I.; Kataoka, Kosuke; Rahima, Bibi; Jackson, Raymond J.; Komase, Katsuhiro; Dohi, Taeko; Boyaka, Prosper N.; Takeda, Yoshifumi; Kiyono, Hiroshi; McGhee, Jerry R.; Fujihashi, Kohtaro. 2006. A second generation of double mutant cholera toxin adjuvants: Enhanced immunity without intracellular trafficking. Journal of Immunology. Vol. 177, no. 5: 3045-3054. (IF: 6)
Fischer, Romy; Debbabi, Hajer; Blais, Anne; Dubarry, Michel; Rautureau, Michele; Boyaka, Prosper N.; Tome, Daniel. 2007. Uptake of ingested bovine lactoferrin and its accumulation in adult mouse tissues. International Immunopharmacology. Vol. 10: 1387-1393.
Fischer, Romy; Tome, Daniel; McGhee, Jerry R.; Boyaka, Prosper N. 2007. Th1 and Th2 cells are required for both eosinophil- and neutrophil-associated airway inflammatory responses in mice. Biochemical and Biophysical Research Communications. Vol. 357, no. 1: 44-49.
Youn, Hyun-Jun; Ko, Sung-Youl; Lee, Kyoo-A.; Ko, Hyun-Jeong; Lee, Yoon-Sook; Fujihashi, Kohtaro; Boyaka, Prosper N.; Kim, Sang-Hee; Horimoto, Taisuke; Kweon, Mi-Na; Kang, Chang-Yuil. 2007. A single intranasal immunization with inactivated influenza virus and alpha-galactosylceramide induces long-term protective immunity without redirecting antigen to the central nervous system. Vaccine. Vol. 25, no. 28: 5189-5198.
Rennolds, J; Boyaka, PN; Bellis, SL; Cormet-Boyaka, E. 2008. Low temperature induces the delivery of mature and immature CFTR to the plasma membrane. Biochem Biophys Res Commun.
Positions
| 1999 - 2006 | Research Assistant Professor, University of Alabama, Department of Microbiology. Birmingham, AL, United States. |
| 2006 - 2006 | Visiting Assoc Professor-Be , The Ohio State University, Veterinary Biosciences . Columbus, OH, United States. |
| 2006 - 2010 | Associate Professor , The Ohio State University, Veterinary Biosciences . Columbus, OH, United States. |
Professional Activities
Research
| 2004 - 2009 | National Institute of Health. Grant Reviewer. Key achievements: Ad Hoc Reviewer; The study section members provide scientific evaluation of research grant proposal submitted for consideration for funding by the National Institute of Health. |
| 2009 - present | National Instutite of Health, Immunity and Host Defense Study Section. Grant Reviewer. Key achievements: The study section members provide scientific evaluation of research grant proposal submitted for consideration for funding by the National Institute of Health. |
Undergrad., Grad. and Prof. Courses Taught
1999. University of Alabama, Cellular and Molecular Biology (CMB) Ph.D. Program. Cytokine Regulation of Immune Responses 2 credit hours
Autumn 2007. The Ohio State University College of Veterinary Medicine, Functional Histology of the Gastrointestinal tract CVM 530.
Winter 2009. The Ohio State University College of Veterinary Medicine, Gastrointestinal Immunology Vet Clin Sci 822.02.
Spring 2011. Veterinary Medicine COLMBUS, Veterinary Biosciences. Vet Immunobiology 717 . 3 credit hours
Autumn 2011. The College of Medicine COLMBUS, Integrated Biomedical Science. SPTS-Immunology 880.01. 3 credit hours
Autumn 2011. Veterinary Medicine COLMBUS, Veterinary Medicine. Tisue Struct-Funct 530 . 5 credit hours