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Preeti Pancholi, PhD


Staff photo

1492 E Broad St
3rd Floor Labs
Columbus, OH 43205

Phone: (614) 257-3488

Email: pancholi.3@osu.edu

 

Current OSU Appointments

Professor-Clinical, Pathology

Physician, FGP-Pathology

 

Clinical Interest

Clinical Pathology;Infectious Disease;Medical Microbiology;Public Health

Continuing Education, Extension, and Other Courses Taught

I enjoy participating in Continuing Education for lab technologists. I participate in lab week activities every year where I present a challenging topic on new, emerging technologies that can have a profound effect on clinical microbiology diagnostics.

I also present annually, in the month of February or March, a "Year in Review" to the lab personnel in clinical microbiology where I summarize all the accomplishments for the entire division that includes the various specialties within clinical microbiology for that year. This is accompanied with lunch.

Postdoctoral / Researcher Advising

Hosted international MD, PhD Fellow (Dr. Wenli Zhang) from China for a one year clinical microbiology fellowship (April 2011 to April 2012). She was awarded a one year scholarship under the State Scholarship Fund to pursue study in the United States of America as a visiting scholar. She was selected through a rigid academia evaluation process organized by the China Scholarship Council in 2010 as a non-profit institution affiliated with the Ministry of Education of the P.R. China. Dr. Zhang investigated colistin resistance in Acinetobacter baumannii as her research project. The manuscript is in preparation.

Master/Graduate Advising

Yes, information detailed below.

Partnership Narrative

Clinical Microbiology is an integral field that interphases many disciplines. Over the years, I have had the opportunity to collaborate with several colleagues from Infectious diseases, pharmacy, internal medicine and veteniary sciences.
Collaborative projects have included the following:
1. In collaboration with the antimicrobial stewardship program and pharmacists, we have studied the impact of implementation of rapid technologies (such as real-time PCR) on patient care and hospital cost savings.
2. In collaboration with infectious disease physicians, I have been involved with a number of projects on MRSA studying the epidemiology of Methicillin-Resistant Staphylococcus aureus including characterization of epidemiologic, molecular, geographic, and phylogenetic features. A novel MRSA strain ST239 was identified as circulating in central ohio associated with increased antibiotic resistance and epidemic potential.
3. In collaboration with infectious disease and pharmacy, we have studied antibiotic resistance: synergy testing and testing of untraditional antibiotics (e.g. minocycline)for efficacy against multi-drug resistant micro-organisms
4. In collaboration with veterniary sciences, I have studied genetic elements of multi drug resistance in human strains of A.baumannni. Phenotypic and Genotypic Characterization of Clostridium difficile of Swine and Human Origin was undertaken as part of a masters thesis project. C.difficile isolates were recovered from stool specimens from swine and humans. Isolates were compared using antimicrobial resistance profiles, antimicrobial resistance gene detection, toxin gene detection, RFLP-Toxinotyping, and PFGE.

Academic Advising

2007 - 2009 Madhuri Sopirala, Ohio State University College of Medicine. Graduated 2008.
2010 - 2011 Pamela Fry, The Ohio State University. Graduated 2011. Phenotypic and genotypic characterization of Clostridium difficile of swine and human origin
2010 - 2011 James Scott, The Ohio State University. Graduated 2011. Mycobacterium avium-intracellulare Complex Detection Directly from Clinical Specimens Using Multi-Probe Real-Time PCR
 

Licenses

2007 - present American Board of Medical Microbiology: American College of Microbiology
 

Chapters in Books

Molecular Techniques Applied to the Diagnosis of Infectious Diseases

Immunotherapy of Chronic Hepatitis B Virus Infection

Pulsed Field Gel Electrophoresis (PFGE)

Molecular Microbiology: Diagnostic Principles and Practice

 

Clinical Services

09/01/2005 Clinical Diagnostic Microbiology and Molecular Microbiology (UH main and UHE clinical labs)
10/01/2005 Clinical Microbiology (Univeristy Hospitals Main and University Hospitals East)

Degrees

1988 Ph.D., Postgraduate Institute of Medical Education & Research

 

Editorial Activities

2002 - present Journal of Clinical Microbiology
2002 - 2006 Reviews in Medical Microbiology
2006 - present American Journal of Infection Control
2010 - present Journal of Clinical Virology
 

Honors

1990 - 1992 Heiser Fellowship for Leprosy Research.
1991 - 1992 Grant-in-Aid. The New York Chapter of the Arthritis Foundation.
 

Journal Articles

 

Reference Works

September 2007 Mangino JE, Taylor DL, Giannone PJ, Cordero L, Bannerman T, Pancholi P."Control of an Outbreak of Methicillin-resistant Staphylococcus aureus (MRSA) Bacteremia in a Neonatal Intensive Care Unit (NICU)" .
April 2007 Dickman J, York S, Pancholi P, Young J, Mangino JE."Increase in Bacillus non-anthracis Blood Cultures Associated with Implementation of a New Central Venous Catheter Access Device in a Cancer Hospital" .
September 2007 Sopirala M, Mangino JE, Bannerman T, Pancholi P."Antimicrobial Synergy Testing for Multi-drug Resistant Acinetobacter baumannii: Problematic Organisms and Drug Combinations" .
June 2008 Wolk DM, Picton E, Johnson D, Davis T, Pancholi P, et al."A Multi-site Evaluation of the Cepheid Xpert MRSA Test for Rapid Screening for Methicillin Resistant Staphylococcus aureus from Nasal Specimens" .
April 2008 Wang SH, Mangino JE, Stevenson S, Yakrus MA, Cooksey R, Butler WR, Healy M, Wise MG, Schlesinger LS, Pancholi P."Mycobacterium paraffinicum in a Tertiary Care Medical Center" .
June 2008 Pancholi P, LaRue H."Comparative Evaluation of the VERSANT HIV-1 440 Molecular System and the AMPLICOR HIV-1 MONITOR, for Quantitation of HIV-1 RNA" .
June 2008 Sopirala M, Mangino J, Bannerman T, Pancholi P."An Evaluation of Etest and Checkerboard Methods to Predict Synergy in Multi-drug Resistant Acinetobacter baumannii" .
October 2008 Rene L, Pancholi P, Goff D, Swyers L."Antimicrobial Activities of Doripenem and Other Carbapenems Against Pseudomonas aeruginosa and Other Gram-negative Isolates" .
May 2009 Rajamohan G, Jin H, Pancholi P, Pancholi V."Group A Streptococcal GAPDH, an Anchorless Surface Protein is a Novel Transcription Regulator" .
September 2009 Bauer K, West J, Taylor J, Pancholi P, et al."Clinical Impact of the Cepheid GeneXpert Blood Culture Rapid Polymerase Chain Reaction for Detection of Staphylococcus aureus or Methicillin-resistant Staphylococcus aureus" .
April 2009 Reed E, West J, Rybak MJ, Rossi KL, Vidaillac DC, Balada-Llasat JM, Pancholi P, Goff DA."Characterization of Heteroresistant Vancomycin-intermediate Staphylococcus aureus (hVISA) and Community-associated Methicillin-resistant Staphylococcus aureus (CA-MRSA) in an Academic Hospital Setting" .
November 2009 LaRue H, Travnik L, Swyers L, Balada-Llasat JM, Mangino JE, Pancholi P."Clinical Evaluation and Impact of Xpert MRSA/SA Real-time PCR Testing for the Detection of Staphylococcus aureus and Methicillin Resistant S. aureus (MRSA) in Positive Blood Cultures" .
May 2009 Srinivasan VB, Pancholi P, Pancholi V."A Novel Regulatory Cascade in Streptococcus Pyogenes that Modulates the Expression of a Bacterial Chain-forming Cell Wall Hydrolase CdhA" .
October 2009 Wang S, Bacon T, Ervin M, Pancholi P."Evaluation of QuantiFERON-Gold In-tube Assay: Effect of Temperature on Assay Performance" .
November 2009 LaRue J, Balada-Llasat JM, Kelly C, Rigali L, Pancholi P."Multiplex Respiratory Virus PCR: A Comparison of the ResPlex II v2.0, MultiCode-PLx, and xTAG Systems" .
March 2009 Sopirala MM, Taylor DL, Wellington L, Kulich P, Fawley L, Dickman J, Pancholi P, Mangino JE."Infection Control Link Nurse Program to Target Healthcare Acquired Infections" .
April 2010 Wang S, Khan Y, Hines L, Kent K, DeMita R, Soni R, Pancholi P, Stevenson K."Utilization of Molecular Genotyping and Geocoding to Understand Clonal Associations Among Methicillin-resistant Staphylococcus aureus (MRSA) in the Community" . : 679
November 2010 Balada-Llasat JM, LaRue H, Rigali L, Pancholi P."Comparison of the ERAGEN MultiCODE-RTX BK and FOCUS BK VIRUS Real-Time PCR Assays in Plasma and Urine Specimens" .
November 2010 Pancholi P, LaRue H, Rigali L, Balada-Llasat JM."Evaluation of the Abbott RealTime HCV IUO M2000SP/RT Assay: Comparison with the Roche HCV IVD COBAS AmpliPrep/COBAS TaqMan HCV Assay" .
October 2010 Reed EE, Keating E, Bauer KA, West JE, Pancholi P, et al."Decreasing Time to Effective Management of Candidemia Using an Antimicrobial Stewardship Program Approach" .
March 2010 Wang S, Khan Y, Demita R, Hines L, Soni R, Pancholi P, Stevenson K for the CDC Prevention Epicenter Program."Understanding Inter-facility Transmission of Methicillin-resistant Staphylococcus aureus (MRSA): The Role of Traditional and Molecular Epidemiology Methods" .
April 2010 Reed EE, West JE, Rybak MJ, Rossi KL, Vidaillac DC, Balada-Llasat JM, Pancholi P, Goff DA."Characterization of Heteroresistant Vancomycin-Intermediate Staphylococcus aureus (hVISA) and Community-associated Methicillin-resistant Staphylococcus aureus (CA-MRSA) in an Academic Hospital Setting" .
February 2010 Wang S, Khan Y, Hines L, DeMita R, Freshwater J, Soni R, Pancholi P, Stevenson K."Hospital Transmission of MRSA" .
August 2010 O'Connor D, Balada-Llasat JM, Pancholi P."Clinical Microbiology at OSUMC" .
October 2010 Goff DA, Bauer KA, West JE, Balada-Llasat JM, Pancholi P, Mangino JE."Outcomes in Patients with Carbapenemase-Producing Enterobacteriacea Infections: A Matched Case-control Study" .
October 2010 Wang S, Khan Y, Mediavilla J, Hines L, Soni R, Bauer K, West J, Kreiswirth B, Pancholi P, Stevenson K."Emerging ST239 Strain of Methicillin-Resistant Staphylococcus aureus in Midwestern USA" .
October 2010 Wang S, Khan Y, Hines L, DeMita R, Freshwater J, Soni R, Pancholi P, Stevenson K."Hospital Transmission of MRSA" .
March 2010 DeMita R, Wang S, Khan Y, Hines L, Soni R, Pancholi P, Stevenson K for the CDC Prevention Epicenter Program."A Retrospective Review of Clinical Characteristics and Molecular Epidemiology of Methicillin-resistant Staphylococcus aureus (MRSA) Infections at a Large Academic Medical Center" .
June 2011 Zhang W, Bhowmik A, Balada-Llasat JM, Pancholi V, Pancholi P."Understanding the Mechanisms of Colistin Resistance in Clinical Strains of Acinetobacter baumannii" .
April 2011 Tumin R, Wang S, Pancholi P, et al, for the CDC Preventive EpiCenter."Linking Phenotypic Categorization of Methicillin-resistant Staphylococcus aureus (MRSA) Cases with Genotypic and Clinical Characteristics" .
September 2011 Posey J, Pancholi P, Watson J, et al."Community Transmission of Methicillin-resistant Staphylococcus aureus" .
April 2011 Bakker R, Mekonnen L, Wang S, Pancholi P, et al."A Retrospective Review of MRSA Susceptibilities from Long Term Care Facility Patients by REP-PCR Typing" .
November 2011 Balada-Llasat JM, Kelly C, Zhang W, LaRue H, Pancholi P."Multiplex Respiratory Virus PCR: A Comparison of the xTAG and FilmArray Respiratory Panel on Bronchoalveolar Lavage Samples and Other Respiratory Specimens" .
November 2011 Pancholi P, Kelly C, Raczkowski M, Balada-Llasat JM."Detection of Toxigenic Clostridium difficile: Comparison of the Cell Culture Neutralization, Xpert C. difficile and the Illumigene C. difficile Assays" .
September 2011 Reed E, Balada-Llasat JM, Pancholi P, Goff DA."Outcomes of Bacteremic Patients with AmpC-producing Enterobacteriaceae" .
September 2011 Bauer KA, West JE, Goff DA, Cook CH, Balada-Llasat J, Pancholi P, Mangino J."Detection of Clostridium difficile NAP-1 by Real-Time Polymerase Chain Reaction and Potential Association with Severe Disease" .
October 2011 Wang S, Khan Y, Mediavilla J, Hines L, Kreiswirth B, Pancholi P, Stevenson K."Comparison of Community-onset and Healthcare-associated Methicillin-resistant Staphylococcus aureus Blood Stream Infection at an Academic Medical Center for 3 Years" .
October 2011 Wang S, Khan Y, Hines L, Pancholi P, et al. for the CDC Prevention Epicenter Program."Molecular Genotyping of Methicillin-resistant Staphylococcus aureus (MRSA) from Tertiary Medical Center and 7 Referring Community Hospitals" .
November 2011 Tumin R, Wang SH, Pancholi P, et al."Relationship of Social and Medical Factors to Other Antimicrobial Resistance Among Methicillin-resistant Staphylococcus aureus Strains" .
January 2011 Voorhees T, Andreoni K, Pancholi P, Davis J."Cytomegalovirus Detection: Toward a Better Use of the Polymerase Chain Reaction" .
April 2011 Wang S, Mediavilla J, King L, Chen L, Khan Y, Hines L, Brandt E, Bannerman T, Hoet A, Pancholi P, et al. for the CDC Prevention Epicenter Program."Utilization of Molecular Genotyping and Geocoding to Improve Understanding of the Transmission Dynamics of Recently Emerging ST239-MRSA-III in Ohio" .
September 2011 Reed E, Balada-Llasat JM, Pancholi P."Comparative Evaluation of Identification Methods for AmpC-production in Enterobacteriaceae" .
September 2011 Pancholi P, LaRue H, Kamboj K, et al."Rapid Detection of Yeasts in Blood Cultures Using Multiplex Luminex-based Assay" .
September 2011 Jankowski C, Balada-Llasat J, Raczkowski M, Pancholi P, Goff D."An Antimicrobial Stewardship Approach to Combating Multi-Drug Resistant (MDR) Acinetobacter baumannii with Minocycline" .
April 2012 Balada-Llasat JM, Kelly C, Zhang W, LaRue H, Pancholi P."Multiplex Respiratory Virus PCR: A Comparison of the xTAG and FilmArray Respiratory Panel on Bronchoalveolar Lavage Samples and Other Respiratory Specimens" .
April 2012 Watson J, Pancholi P, Leber A, et al.."Genotypic Diversity of Pediatric Methicillin-resistant Staphylococcus aureus (MRSA) Skin and Soft Tissue Infections (SSTI) in the Community" .
April 2012 Pancholi P, Kelly C, Raczkowski M, Balada-Llasat JM."Detection of Toxigenic Clostridium difficile: Comparison of the Cell Culture Neutralization, Xpert C. difficile and the Illumigene C. difficile Assays." .
Zikri N, Exline MC, Mangino JE, Ali N, Torrence K, Vermillion B, St. Clair J, Lustberg M, Pancholi P, et al."Beyond the Bundle: Role of the Environment on Central Line-Associated Blood Stream Infections" .
Pancholi P, Swyers L, LaRue H, Balada-Llasat JM."Performance of the Nanosphere Verigene Gram-Positive Blood Culture Nucleic Acid Test for Rapid Detection of S. aureus, S. epidermidis and MecA Directly from Positive Blood Cultures" .
Wang SH, Pancholi P, Bijlani N, et al."Development of Bio-Informatics Research Network for Methicillin-Resistant Staphylococcus aureus (MRSA) Blood Stream Infections: A Multicenter Regional MRSA Surveillance Collaborative for Genotyping, Geocoding, and Data Collection for Outbreaak Investigation" .
Posey J, Leber I, Watson J, Pancholi P, et al."Correlation of Molecular Genotypes of Pediatric Methicillin-Resistant Staphylococcus aureus Skin and Soft Tissue Infections and Healthcare Worker Nasal Screens from 10 Primary Care Clinics" .
Taylor JM, Pancholi P, Balada-Llasat JM."Use of Combination Antibiograms to Determine Empiric Double-coverage of Gram-negative Organisms" .

Presentations

TB: Challenges for the Laboratory

Laboratory Evaluation of TB

MRSA and Molecular Microbiology Testing

Clinical Virology: Role of Molecular Diagnostics

Evolving Respiratory Viral Testing and its Impact on Patient Management

Clinical Impact of Rapid Molecular Tests for Blood Cultures

Advances in HCV Viral Load Testing

Rapid Detection of Yeasts in Blood Cultures using Multiplex Luminex-based Assay

Laboratory Detection of Toxigenic Clostridium difficile

Practical Experience with MALDI Biotyper in the Laboratory

Molecular epidemiology

A 68-Year-Old Man With Follicular Lymphoma Presenting With Fever and Chills

 

Professional Activities

2011 - present Judge at Dublin PROUD Science Fair. Dublin City Schools. Dublin, OH, OH.
2010 Mentorship of High School Science Teacher.
2010 OSU Consultant. The Ohio Department Of Health.
2001 - 2011 Career Day presentations at Elementary school. elementary.
 

Unpublished Works

Cytomegalovirus Detection: Toward a Better Use of the Polymerase Chain Reaction

Understanding the mechanisms of colistin resistance in clinical strains of Acinetobacter baumannii

FilmArray RP versus xTAG RVP for respiratory virus detection

Fatal Kytococcus schroeteri bacteremic pneumonia: Case report and review of the literature

Phenotypic and genotypic comparison of clostridium difficile of human and wine origin from Ohio, USA

An Antimicrobial Stewardship Program (ASP) approach to improve the management of Candidemia

Comparison of repetitive element-polymerase chain reaction to Pulsed-Field Gel Electrophoresis, Staphylococcal Cassette Chromosome mec Typing, and spa Tying for comparing molecular diversity of methicillin-resistant Staphylococcus aureus (MRSA) infections at a large academic medical center

Beyond the bundle - Journey of a tertiary care medical intensive care unit to zero central line-associated blood stream infections

Link nurse program: An interdisciplinary approach to infection prevention

An antimicrobial stewardship program's approach to Klebsiella-pneumoniae carbapenemase (KPC)-producing K.pneumoniae: Impact on clinical and economic outcomes