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Murugesan Rajaram, PhD


460 W 12th Ave
Columbus, OH 43210

Phone: (614) 688-8024

Email: rajaram.3@osu.edu

 

Current OSU Appointment

Research Assistant Professor, SBS-Microbial Infectn/Immunity

 

Academic Advising

2008 Bin Ni, The Ohio State University. Graduated 0.
2011 Daniel House, The Ohio State University. Graduated 0.
2013 Ky Hoang, OSU Center for Microbial Interface Biology CMIB. Graduated 0.
2013 Claire Dood, The Ohio State University. Graduated 0.
2004 - 2006 Ragu Kanagasabai, The Ohio State University. Graduated 0.
2008 - 2009 Jessica Morris, The Ohio State University. Graduated 0.
2009 Bret Betz, Ohio State University College of Medicine. Graduated 2012.
2008 - 2011 Michelle N., The Ohio State University. Graduated 2011.
2009 - 2011 Huy Nguyen, OSU Center for Microbial Interface Biology CMIB. Graduated 0.
2012 Alaric W.D., Yale University. Graduated 0.
 

Books

Tracy K Carlson, Michelle N Brooks, Douglas A. Meyer, Lisa Henning, Murugesan VS Rajaram and Larry S Schlesinger. Pulmonary innate immunity: Soluble and cellular host defenses of the lung. Trivandrum, India, IN|IND: Transworld Research Network, June 2010.

 

Chapters in Books

Tracy K.Carlosn, Michelle Brooks, Douglas A.Meyer, Lisa Henning, Murugesan V.S.Rajaram and Larry S.Schlesinger.. "Pulmonar innate immunity:Soluble and cellular host defenses of the lung.." In Regulation of Innate Immune Function. Edited by Clay B.Marsh, Susheela Tridandapani and Melissa G.Piper. 165-211. Trivandrum, IN|IND: Transworld Research Network, August 2012.

 

Degrees

2000 Ph.D., University Of Madras India

 

Honors

2010 First Prize In 2010 Research Poster presentation. Dorothy M. Davis Heart & Lung Research Institute.
2011 - present 1st prize 2011 Research Poster Competition. Dorothy M. Davis Heart & Lung research Institute.
2012 - present 2nd Place in 2012 Research poster competition. Dorothy M. Davis Heart & Lung Research Institute.
2014 Early Career Faculty Travel Grant. American Association of Immunology.
2015 Session Chair. American Association of Immunology.
2016 AAI Early Career Faculty Travel grant. Career Development and Oral presentation.
 

Journal Articles

Hoang KV, Borteh HM, Rajaram MV, Peine KJ, Curry H, Collier MA, Homsy ML, Bachelder EM, Gunn JS, Schlesinger LS, Ainslie KM.. "Acetalated dextran encapsulated AR-12 as a host-directed therapy to control Salmonella infection.." International Journal of Pharmaceutics. (January 0.): -.

Rajaram,Murugesan,VS; Ganesan,Latha,P; Parsa,Kishore,VL; Butchar,Jonathan,P; Gunn,John,S; Tridandapani,Susheela. "Akt/protein kinase B modulates macrophage inflammatory response to Francisella infection and confers a survival advantage in mice." JOURNAL OF IMMUNOLOGY. Vol. 177, no. 9. (November 2006.): 6317-6324.

Parsa,Kishore,VL; Ganesan,Latha,P; Rajaram,Murugesan,VS; Gavrilin,Mikhail,A; Balagopal,Ashwin; Mohapatra,Nrusingh,P; Wewers,Mark,D; Schlesinger,Larry,S; Gunn,John,S; Tridandapani,Susheela. "Macrophage pro-inflammatory response to Francisella novicida infection is regulated by SHIP." PLOS PATHOGENS. Vol. 2, no. 7. (July 2006.): 681-690.

Butchar,Jonathan,P; Rajaram,Murugesan,VS; Ganesan,Latha,P; Parsa,Kishore,VL; Clay,Corey,D; Schlesinger,Larry,S; Tridandapani,Susheela. "Francisella tularensis induces IL-23 production in human monocytes." JOURNAL OF IMMUNOLOGY. Vol. 178, no. 7. (April 2007.): 4445-4454.

Weir,Nathan,M; Selvendiran,Karuppaiyah; Kutala,Vijay,Kumar; Tong,Liyue; Vishwanath,Shilpa; Rajaram,Murugesan; Tridandapani,Susheela; Anant,Shrikant; Kuppusamy,Periannan. "Curcumin induces G2/M arrest and apoptosis in cisplatin-resistant human ovarian cancer cells by modulating Akt and p38 MAPK." CANCER BIOLOGY & THERAPY. Vol. 6, no. 2. (February 2007.): 178-184.

Parsa,Kishore,VL; Butchar,Jonathan,P; Rajaram,Murugesan,VS; Cremer,Thomas,J; Tridandapani,Susheela. "The tyrosine kinase Syk promotes phagocytosis of Francisella through the activation of Erk." MOLECULAR IMMUNOLOGY. Vol. 45, no. 10. (May 2008.): 3012-3021.

Parsa,Kishore,VL; Butchar,Jonathan,P; Rajaram,Murugesan,VS; Cremer,Thomas,J; Gunn,John,S; Schlesinger,Larry,S; Tridandapani,Susheela. "Francisella gains a survival advantage within mononuclear phagocytes by suppressing the host IFN gamma response." MOLECULAR IMMUNOLOGY. Vol. 45, no. 12. (July 2008.): 3428-3437.

Rajaram,Murugesan,VS; Butchar,Jonathan,P; Parsa,Kishore,VL; Cremer,Thomas,J; Amer,Amal; Schlesinger,Larry,S; Tridandapani,Susheela. "Akt and SHIP Modulate Francisella Escape from the Phagosome and Induction of the Fas-Mediated Death Pathway." PLOS ONE. Vol. 4, no. 11. (November 2009.): e7919-.

Sweet,Lindsay; Singh,Prachi,P; Azad,Abul,K; Rajaram,Murugesan,VS; Schlesinger,Larry,S; Schorey,Jeffrey,S. "Mannose Receptor-Dependent Delay in Phagosome Maturation by Mycobacterium avium Glycopeptidolipids." INFECTION AND IMMUNITY. Vol. 78, no. 1. (January 2010.): 518-526.

Mohapatra,Nrusingh,P; Soni,Shilpa; Rajaram,Murugesan,VS; Dang,Pham,My-Chan; Reilly,Tom,J; El-Benna,Jamel; Clay,Corey,D; Schlesinger,Larry,S; Gunn,John,S. "Francisella Acid Phosphatases Inactivate the NADPH Oxidase in Human Phagocytes." JOURNAL OF IMMUNOLOGY. Vol. 184, no. 9. (May 2010.): 5141-5150.

Rajaram,Murugesan,VS; Brooks,Michelle,N; Morris,Jessica,D; Torrelles,Jordi,B; Azad,Abul,K; Schlesinger,Larry,S. "Mycobacterium tuberculosis Activates Human Macrophage Peroxisome Proliferator-Activated Receptor gamma Linking Mannose Receptor Recognition to Regulation of Immune Responses." JOURNAL OF IMMUNOLOGY. Vol. 185, no. 2. (July 2010.): 929-942.

Brooks,Michelle,N; Rajaram,Murugesan,VS; Azad,Abul,K; Amer,Amal,O; Valdivia-Arenas,Martin,A; Park,Jong-Hwan; Nunez,Gabriel; Schlesinger,Larry,S. "NOD2 controls the nature of the inflammatory response and subsequent fate of Mycobacterium tuberculosis and M-bovis BCG in human macrophages." CELLULAR MICROBIOLOGY. Vol. 13, no. 3. (March 2011.): 402-418.

Rajaram,Murugesan,VS; Ni,Bin; Morris,Jessica,D; Brooks,Michelle,N; Carlson,Tracy,K; Bakthavachalu,Baskar; Schoenberg,Daniel,R; Torrelles,Jordi,B; Schlesinger,Larry,S. "Mycobacterium tuberculosis lipomannan blocks TNF biosynthesis by regulating macrophage MAPK-activated protein kinase 2 (MK2) and microRNA miR-125b." PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. Vol. 108, no. 42. (October 2011.): 17408-17413.

Torrelles,Jordi,B; Sieling,Peter,A; Arcos,Jesus; Knaup,Rose; Bartling,Craig; Rajaram,Murugesan,VS; Stenger,Steffen; Modlin,Robert,L; Schlesinger,Larry,S. "Structural Differences in Lipomannans from Pathogenic and Nonpathogenic Mycobacteria That Impact CD1b-restricted T Cell Responses." JOURNAL OF BIOLOGICAL CHEMISTRY. Vol. 286, no. 41. (October 2011.): 35438-35446.

Betz,Bret,E; Azad,Abul,K; Morris,Jessica,D; Rajaram,Murugesan,VS; Schlesinger,Larry,S. "beta-Glucans inhibit intracellular growth of Mycobacterium bovis BCG but not virulent Mycobacterium tuberculosis in human macrophages." MICROBIAL PATHOGENESIS. Vol. 51, no. 4. (October 2011.): 233-242.

Cremer,Thomas,J; Fatehchand,Kavin; Shah,Prexy; Gillette,Devyn; Patel,Hemal; Marsh,Rachel,L; Besecker,Beth,Y; Rajaram,Murugesan,VS; Cormet-Boyaka,Estelle; Kanneganti,Thirumala-Devi; Schlesinger,Larry,S; Butchar,Jonathan,P; Tridandapani,Susheela. "MiR-155 induction by microbes/microbial ligands requires NF-?B-dependent de novo protein synthesis.." Frontiers in cellular and infection microbiology. Vol. 2, (January 2012.): 73-?.

Nguyen,Huy,A; Rajaram,Murugesan,VS; Meyer,Douglas,A; Schlesinger,Larry,S. "Pulmonary surfactant protein A and surfactant lipids upregulate IRAK-M, a negative regulator of TLR-mediated inflammation in human macrophages." AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY. Vol. 303, no. 7. (October 2012.): L608-L616.

Canan,Cynthia; Rajaram,Murugesan; Turner,Joanne. "Understanding altered toll-like receptor function in the elderly." JOURNAL OF IMMUNOLOGY. Vol. 190, (May 2013.): P4251-.

Young,Nicholas,A; Wu,Lai-Chu; Burd,Craig; Friedman,Alexandra; Kaffenberger,Benjamin; Rajaram,Murugesan; Schlesinger,Larry,S; James,Hayley; Shupnik,Margaret; Jarjour,Wael,N. "Estrogen Modulates The Expression Of Endosome-Associated Toll-Like Receptor 8 Through Estrogen Receptor-alpha Which May Contribute To Sex-Bias In Systemic Lupus Erythematosus." ARTHRITIS AND RHEUMATISM. Vol. 65, (October 2013.): S270-S271.

Young,Nicholas,A; Friedman,Alexandra,K; Kaffenberger,Benjamin; Rajaram,Murugesan,VS; Birmingham,Daniell,J; Rovin,Brad,H; Hebert,Lee,A; Schlesinger,Larry,S; Wu,Lai-Chu; Jarjour,Wael,N. "Novel estrogen target gene ZAS3 is overexpressed in systemic lupus erythematosus." MOLECULAR IMMUNOLOGY. Vol. 54, no. 1. (May 2013.): 23-31.

Dai,Shipan; Rajaram,Murugesan,VS; Curry,Heather,M; Leander,Rachel; Schlesinger,Larry,S. "Fine Tuning Inflammation at the Front Door: Macrophage Complement Receptor 3-mediates Phagocytosis and Immune Suppression for Francisella tularensis." PLOS PATHOGENS. Vol. 9, no. 1. (January 2013.): e1003114-.

Mohapatra,Nrusingh,P; Soni,Shilpa; Rajaram,Murugesan,VS; Strandberg,Kristi,L; Gunn,John,S. "Type A Francisella tularensis Acid Phosphatases Contribute to Pathogenesis." PLOS ONE. Vol. 8, no. 2. (February 2013.): e56834-.

Moliva,Juan,I; Rajaram,Murugesan,VS; Sidiki,Sabeen; Sasindran,Smitha,J; Guirado,Evelyn; Pan,Xueliang,Jeff; Wang,Shu-hua; Ross,Patrick; Lafuse,William,P; Schlesinger,Larry,S; Turner,Joanne; Torrelles,Jordi,B. "Molecular composition of the alveolar lining fluid in the aging lung.." Age. Vol. 36, no. 3. (June 2014.): 9633-?.

Moliva,Juan,I; Rajaram,Murugesan,VS; Sidiki,Sabeen; Sasindran,Smitha,J; Guirado,Evelyn; Pan,Xueliang,Jeff; Wang,Shu-hua; Ross,Patrick; Lafuse,William,P; Schlesinger,Larry,S; Turner,Joanne; Torrelles,Jordi,B. "Molecular composition of the alveolar lining fluid in the aging lung." AGE. Vol. 36, no. 3. (June 2014.): 1187-1199.

Azad AK, Rajaram MV, Schlesinger LS.. "Exploitation of the Macrophage Mannose Receptor (CD206) in Infectious Disease Diagnostics and Therapeutics.." Journal of Cytology and Molecular Biology. Vol. 1, no. 1. (January 2014.): 6-.

Moliva JI, Rajaram MV, Sidiki S, Sasindran SJ, Guirado E, Pan XJ, Wang SH, Ross P Jr, Lafuse WP, Schlesinger LS, Turner J, Torrelles JB.. "Molecular composition of the alveolar lining fluid in the aging lung.." Age. Vol. ePUBMED, (March 2014.): 24584696-.

Hansen JM, Golchin SA, Veyrier FJ, Domenech P, Boneca IG, Azad AK, Rajaram MV, Schlesinger LS, Divangahi M, Reed MB, Behr MA.. "N-glycolylated peptidoglycan contributes to the immunogenicity but not pathogenicity of Mycobacterium tuberculosis.." The Journal of Infectious Disease. Vol. 209, no. 7. (April 2014.): 1045-54.

Young NA, Wu LC, Burd CJ, Friedman AK, Kaffenberger BH, Rajaram MV, Schlesinger LS, James H, Shupnik MA, Jarjour WN.. "Estrogen modulation of endosome-associated toll-like receptor 8: an IFNα-independent mechanism of sex-bias in systemic lupus erythematosus.." Clinical Immunology. Vol. 151, no. 1. (March 2014.): 66-77.

Ni B, Rajaram MV, Lafuse WP, Landes MB, Schlesinger LS.. "Mycobacterium tuberculosis decreases human macrophage IFN-γ responsiveness through miR-132 and miR-26a.." Journal of Immunology. Vol. 193, no. 9. (November 2014.): 4537-47.

Rajaram MV, Ni B, Dodd CE, Schlesinger LS.. "Macrophage immunoregulatory pathways in tuberculosis.." Seminars In Immunology. Vol. 26, no. 6. (August 2014.): 471-85.

Young NA, Wu LC, Burd CJ, Friedman AK, Kaffenberger BH, Rajaram MV, Schlesinger LS, James H, Shupnik MA, Jarjour WN.. "Estrogen modulation of endosome-associated toll-like receptor 8: an IFNα-independent mechanism of sex-bias in systemic lupus erythematosus.." Clinical Immunology. Vol. 151, no. 1. (March 2014.): 66-77.

Hansen,Jesse,M; Golchin,Solmaz,A; Veyrier,Frederic,J; Domenech,Pilar; Boneca,Ivo,G; Azad,Abul,K; Rajaram,Murugesan,VS; Schlesinger,Larry,S; Divangahi,Maziar; Reed,Michael,B; Behr,Marcel,A. "N-Glycolylated Peptidoglycan Contributes to the Immunogenicity but Not Pathogenicity of Mycobacterium tuberculosis." JOURNAL OF INFECTIOUS DISEASES. Vol. 209, no. 7. (April 2014.): 1045-1054.

Azad,Abul,K; Rajaram,Murugesan,VS; Metz,Wendy,L; Cope,Frederick,O; Blue,Michael,S; Vera,David,R; Schlesinger,Larry,S. "gamma-Tilmanocept, a New Radiopharmaceutical Tracer for Cancer Sentinel Lymph Nodes, Binds to the Mannose Receptor (CD206)." JOURNAL OF IMMUNOLOGY. Vol. 195, no. 5. (September 2015.): 2019-2029.

Landes,Michelle,B; Rajaram,Murugesan,VS; Nguyen,Huy; Schlesinger,Larry,S. "Role for NOD2 in Mycobacterium tuberculosis-induced iNOS expression and NO production in human macrophages.." Journal of leukocyte biology. Vol. 97, no. 6. (June 2015.): 1111-1119.

Chesarino NM, Hach JC, Chen JL, Zaro BW, Rajaram MV, Turner J, Schlesinger LS, Pratt MR, Hang HC, Yount JS.. "Chemoproteomics reveals Toll-like receptor fatty acylation.." BMC Biology. Vol. 12, no. 1. (November 2015.): 91-.

Landes MB, Rajaram MV, Nguyen H, Schlesinger LS.. "Role for NOD2 in Mycobacterium tuberculosis-induced iNOS expression and NO production in human macrophages.." Journal of Lecukocyte Biology. Vol. pii: jlb.3A1114-557R, (March 2015.): pii: jlb.3A1114-557R.

Ganesan,Latha,P; Mates,Jessica,M; Cheplowitz,Alana,M; Avila,Christina,L; Zimmerer,Jason,M; Yao,Zhili; Maiseyeu,Andrei; Rajaram,Murugesan,VS; Robinson,John,M; Anderson,Clark,L. "Scavenger receptor B1, the HDL receptor, is expressed abundantly in liver sinusoidal endothelial cells." SCIENTIFIC REPORTS. Vol. 6, (February 2016.): 20646-.

 

Presentations

"Mycobacterium tuberculosis activates human macrophage PPARγ linking mannose receptor recognition to regulation of immune responses." Presented at CMIB research re-treat 2010, . (March 2010)

"M. tuberculosis lipomannan blocks TNF biosynthesis by regulating macrophage MAPK-Activated Protein Kinase 2 (MK2) and miR125b." Presented at CMIB Work In Progress, Columbus, US|USA. (January 2011)

"Unraveling the Mystery of Macrophage Mannose Receptor Signaling: a Major Pattern Recognition Receptor in Immunity." Presented at CMIB Work In Progress, . (January 2012)

"Mannose receptor (CD206)-mediated signaling events in human macrophages in the context of tuberculosis." Presented at CMIB WIP, . (March 2013)

"Mannose receptor mediated signaling in human macrophages in the context of tuberculosis." Presented at American Association of Immunologist Annual Meeting 2014, Piitsburg, PA, US|USA. (May 2014)

"AAI annual meeting Block Symposium." Presented at AAI Annual Meeting 2015, New Orleans, LA, US|USA. (May 2015)

"FcR-chain, Grb2 and SHP-1 are invovled in mannose receptor (CD206)-mediated signaling in relation to tuberculosis." Presented at AAI Annual Meeting, New Orleans, LA, US|USA. (May 2015)

"Oral: Cardiac electrical and structural changes during bacterial infection: an instructive model to study cardiac dysfunction in sepsis." Presented at AAI Annual Meeting, Seattle, WA, US|USA. (May 2016)

 

Technical Reports

Murugesan V. S. Rajaram, Michelle N. Brooks, Jessica D. Morris, Jordi B. Torrelles, Abul K. Azad, and Larry S. Schlesinger, "Tuberculosis Tyranny". Vol. 185. no. 2. Edited by Christiana N. Fogg, Ph.D.. American Association of Immunology. (3, 2010) [Peer-Review] (Published)

 

Unpublished Works

1. Yao, Z, Cheplowitz, A. M, Hammer, L.P, Mates, J. M, Maiseyeu, A, Robinson, J. M,. Rapid elimination of blood-borne LPS by liver sinusoidal endothelial cells is mediated by HDL.. April 2016.

2. Murugesan V.S. Rajaram, Eusondia Arnett, Abul K. Azad , Evelyn Guirado, Bin Ni, Li-Zhen He, Tibor Keler, Lawrence J. Thomas, William P. Lafuse and Larry S. Schlesinger.. Human mannose receptor signaling controls macrophage recognition and immune response. Planning to submit this manuscript to Cell on or before end of July.. January 0.

1. Michael A. Makara, Ky V. Hoang, Latha P. Ganesan, Elliot D. Crouser, John S. Gunn, Joanne Turner, Larry S. Schlesinger, Peter J. Mohler, and Murugesan V.S. Rajaram. Cardiac electrical and structural changes during bacterial infection: an instructive model to study cardiac dysfunction in sepsis.. May 2016.

2. Claire E. Dodd, Charlie J. Pyle, Rebecca Glowinski, Murugesan V.S. Rajaram, & Larry S. Schlesinger. CD36-mediated uptake of surfactant lipids by human macrophages promotes intracellular growth of Mycobacterium tuberculosis.. June 2016.