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Mikhail Gavrilin, PhD


473 W 12th Ave
Columbus, OH 43210

Phone: (614) 292-8945

Email: gavrilin.1@osu.edu

 

Current OSU Appointment

Research Assistant Professor, Pulm,Allergy,Crit Care & Sleep

 

Chapters in Books

Devesa J, García-Barros M, Costoya JA, Gondar M, Gavrilina T, Gavrilin M, Arce V. "Expresión de los genes de hormona de crecimiento, variantes moleculares y acciones biológicas de estas variantes." In Retrasos del crecimiento. Edited by B. Moreno. 29-44. Madrid, ES|ESP: Díaz de Santos, January 1995.

Podell, M., Buck, W.R., Hayes, K.A., Gavrilin, M.A., Mathes LE. "Animal Models of Retroviral Encephalopathies: Feline Model.." In Current Protocols in Neuroscience. Edited by (J.N. Crawley, C.R. Gerfen, M.A. Rogawski, D.R. Sibley, P. Skolnick, and S. Wray, eds). 9.9.1-9.9.30. New York, US|USA: John Wiley & Sons, January 2001.

 

Conferences

Gavrilin MA. "Glucocorticoid reception in liver of rats living in the radiocontaminated regions and under the hypo-function of thyroid gland." Republican Scientific-practical radiobiological and radioecological conference. (December 1988). .

Luksha GL, Popoff EH, Savateev SK, Naumov AD, Montik VI, Filchenkov GN, Gavrilin MA. "Steroid hormone reception during low doses gamma-irradiation." 1st All-Union Radiobiological congress. (August 1989). 1153-1154.

Konoplya EF, Gavrilin MA, Luksha GL. "Mechanisms of glucocorticoid action on cell level." Regional scientific conference. (December 1989). 30-31.

Luksha GL, Gavrilin MA. "Influence of radioecological situation, internal, external and combined irradiation on the binding of the dexamethasone with the rat spleen lymphocytes." 1st Belarus Immunological Congress. (November 1990). 72-73.

Konoplya EF, Luksha GL, Gavrilin MA, Montik VI, Seliavko VV. "Intracellular cycle of corticosteroid receptors." All-Union symposium "Biochemistry of the receptor systems". (November 1990). 30-31.

Konoplya EF, Gavrilin MA, Luksha GL, Naumov AD, Popoff EH, Sechko LK. "The level and reception of the steroid hormones during the low doses irradiation (external, internal and combined).." 1st All-Union symposium "Molecular-cellular mechanisms of chronic (external and internal) action of the radiation on the biological systems". (December 1990). 61-.

Gavrilin MA, Luksha GL. "Rat liver glucocorticoid reception during internal and combined irradiation." Scientific-practical radiobiology and radioecology conference. (December 1990). 40-.

Luksha GL, Gavrilin MA, Konoplya EF. "Stimulation of glucocorticoid-binding activity in lymphoid cells of rats after irradiation with low doses." XXII annual meeting of European society of new methods in research. (September 1991). 16-.

Luksha GL, Gavrilin MA. "Influence of low doses irradiation on the Gomel residents health." III Republic conference "Scientific-practical aspects of health defense of the people exposed to radiation as a result of Chernobyl accident". (December 1991). 79-.

Luksha GL, Gavrilin MA. "Glucocorticoid reception in the tissues with different radiosensitivity of animals living in the nearest Chernobyl area." Radiobiological Congress.. (September 1993). 610-.

Gavrilin MA, Luksha GL. "100. Gavrilin MA, Luksha GL. Influence of the internal and combined irradiation on the glucocorticoid reception in rat liver." Radiobiological Congress.. (September 1993). 198-.

Shevko VA, Bortkevich LG, Maslovskaya AM, Gavrilin MA, Seliavko VV, Latisheva VY, Shavlov NM. "The content of natural killer cells subpopulation in the peripheral blood of the Gomel provincia habitants." of II Belarus Immunology and Allergology Society. (October 1993). .

Luksha GL, Gavrilin MA. "Molecular mechanisms of the low doses irradiation influence on regulation of the intracellular glucocorticoid reception." Belarus-Japan Symposium "Acute and Late Concequences of Nuclear Catastrophes: Hiroshima-Nagasaki and Chernobyl". (October 1993). 100-.

Luksha GL, Gavrilin MA. "Postirradiational disorders in the system of nuclear reception of the thyroid hormones." International Symposium "Science and Medicine - for the Chernobyl". (November 1993). 80-81.

Luksha GL, Gavrilin MA. "Intracellular hormone reception after irradiation." 2nd International Conference "Radiobiological Consequences of Nuclear Accidents".. (October 1994). 142-.

Boyko V.N., Luksha G.L., Gavrilin M.A., Petrov A.S., Antushevich A.E., Kalinin N.L.. "Complex medical examination of habitants living in the radiocontaminated regions of the Republic of Belarus." Proceedings of the Belarus-Japan Symposium "Acute and Late Consequences of Nuclear Catastrophes: Hiroshima-Nagasaki and Chernobyl.�. (January 1994). 357-366.

Gavrilin M.A., Luksha G.L. "Influence of the combined low doses irradiation on the intracellular glucocorticoid reception." Proceedings of the Belarus-Japan Symposium "Acute and Late Consequences of Nuclear Catastrophes: Hiroshima-Nagasaki and Chernobyl.". (January 1994). 549-560.

Gavrilin MA, Luksha GL. "Glucocorticoid function of an organism and irradiation." International Scientific Conference "Ten years after Chernobyl catastrophe (scientific aspects of problem)". (January 1995). .

Garcia-Barros M, Gondar M, Gavrilin M, Costoya JA, Arce V, Devesa J. "Variantes moleculares de GH generados en higado." VIII Congreso Sociedad Gallega Endocrinologia, Nutricion y Metabolismo. (January 1995). .

Garcia-Barros M, Gondar M, Gavrilin M, Costoya JA, Arce V, Devesa J. "The hepatic metabolism of Growth Hormone." Novo Nordisk International Symposium on Growth. (January 1995). .

Garcia-Barros M, Gavrilin M, Gondar M, Arce, V, Devesa J. "Procesamiento metabolico nuclear de GH in vitro." XVII Congreso Sociedad Espanola Endocrinologia Pediatrica. (January 1995). .

Arce V, Costoya JA, Gavrilin M, Garcia-Barros M, Gavrilina T, Devesa J. "Procesamiento alternativo en la sintesis hepatica de hGH." XXXVIII Congreso Sociedad Espanola Endocrinologia. (January 1995). .

Ladutko EI, Gavrilin MA. "The influence of gamma-irradiation on the state of adrenal cortex, thyroid gland and glucocorticoid reception in cytosol of rat liver." International Scientific Conference “Academic and Applied Aspects of Radiobiology: Biological Effects of Low Doses and Radioactive Contamination of Environment (Radioecological and Medico-Biological consequences of Chernobyl Nuclear Accident)�. (January 1998). .

Buck WR, Gavrilin MA, Podell M. "Assesment of glutamate transporter expression during feline immunodeficiency virus infection in cats." Society for Neuroscience. 30 Annual Meeting. (January 2000). .

Gavrilin MA, Podell M. "Methamphetamine enhances lentiviral replication in a feline astrocyte cell lineage." Advances in Veterinary Medicine. (April 2001). .

Gavrilin MA, Podell M. "Methamphetamine enhances FIV-MD replication in feline astrocytes." Society for Neuroscience. 31 Annual Meeting. (November 2001). .

Buck WR.,Gavrilin MA., Mathes LE., Podell M. "Effect of Feline Immunodeficiency Virus and Methamphetamine on the Expression of the Astrocytic Glutamate Transporter GLT-1." 53rd Annual Meeting of The American College of Veterinary Pathologists. (January 2002). .

Gavrilin MA, Mathes LE, Hayes KA, Podell M. "Multiple Psychostimulants Enhance FIV-MD Replication and CXCR4 Expression in Feline Astrocytes During Cell-Associated Infection." 6th International Feline Retrovirus Research Symposium. (December 2002). .

Bao SY, Tripp RP, Gavrilin MA, Diaz PT, Wewers MD, Knoell DL. "HIV-1 Infection of the Human Lung Epithelium by Free Virus and Cell-to-Cell Contact." INTERNATIONAL MEETING OF THE INSTITUTE OF HUMAN VIROLOGY. (September 2003). .

Hall MW, Gavrilin M, Wewers MD. "Monocyte IKB alpha/NFKBP50 mRNA ratio in children with multiple organ dysfunction syndrome (MODS) and prolonged monocyte deactivation (PMD)." Critical Care Medicine.. (January 2003). A13-.

Gavrilin MA, Duncan MD, Wewers MD. "A Novel Quantitation of Endotoxin Induced Gene Expression without External Standards." 2nd Annual Symposium on the Functional Genomics of Critical Illness and Injury. (November 2003). .

Bao SY, Gavrilin MA, Diaz PT, Wewers MD, Knoell DL. "HIV-1 infects differential human lung epithelial cells from the basolateral surface and requires galactosylceramid." American Journal of Respiratory and Critical Care Medicine.. (April 2003). .

Hall MW, Gavrilin MA, Wewers MD. "Monocyte IKB alpha/NFKBP50 mRNA ratio in children with multiple organ dysfunction syndrome (MODS) and prolonged monocyte deactivation (PMD)." Pediatric Research.. (January 2004). 58A-59A.

Seshadri S, Gavrilin MA, Hart J, Duncan MD, Wewers MD. "Pyrin expression is suppressed with monocyte to macrophage differentiation." FASEB Journal.. (January 2005). A1445-.

Bouakl IJ, Gavrilin MA, Wewers MD. "Intracellular activation of the human monocyte inflammasome by Francisella." Proceedings of the American Thoracic Society. (January 2005). A306-.

Gavrilin,M.A., Wewers MD. "infection of monocytes by Francisella activates inflammasome complex." Keystone symposia “Innate Immunity to Pathogens�. (January 2005). .

Fahy RJ, Yang L, Duncan MD, Gavrilin MA, Wewers MD. "Monocyte mRNA expression in early septic shock." Proceedings of the American Thoracic Society. (January 2005). A42-.

Kim HJ, Gavrilin MA, Hart JM, Wewers MD. "Tyrosine 82 in CARD domain of caspase-1 negatively regulates caspase-1 activation." FASEB Journal.. (January 2005). A335-.

Hall MW, Knatz NL, Gavrilin M, Duncan MD, Wewers MD. "Monocyte mRNA expression in pediatric multiple organ dysfunction syndrome (MODS)." Critical Care Medicine.. (January 2005). A152-.

Gavrilin MA, Seshadri S, Hall MW, Wewers MD. "Monocytes and macrophages differ in response to Francisella. A potential regulatory role for pyrin." Great Lake Regional Center of Excellence for Biodefense and Emerging Infectious Diseases. Fourth Annual Meeting.. (November 2006). .

Gavrilin MA , Bouakl IJ, Knatz NL, Duncan MD, Hall MW, Gunn JS, Wewers MD.. "Gavrilin MA, Bouakl IJ, Knatz NL, Duncan MD, Hall MW, Gunn JS, Wewers MD. Internalization and phagosome escape required for Francisella to induce human monocyte IL-1β processing and release." Keystone symposia “Innate Immunity�. (February 2006). .

Fahy RJ, Gavrilin MA, Bhatt NU, Joshi P, Seshadri S, Nagaraja HN, Wewers MD. "Monocyte inflammasome mRNA expression and survival from septic shock." Proceedings of the American Thoracic Society. (January 2006). A35-.

Exline MC, Fahy R, Gavrilin MA, Duncan MD, Wewers MD. "Anti-apoptotic peptide humanin suppressed in monocytes of septic patients." Proceedings of the American Thoracic Society. (January 2006). A328-.

Crouser ED, Eng C, Wewers MD, Knox KS, Huff JE, Julian MW, Gavrilin MA. "Stromal gene expression in mediastinal lymph nodes of sarcoidosis patients." Proceedings of the American Thoracic Society. (January 2006). A794-.

Gavrilin MA, Seshadri S, Mitra S, Hall MW, Wewers MD. "Pyrin (MEFV) is associated with IL-1β processing and release by mononuclear cells infected with Francisella." . Division of Pulmonary, Allergy, Critical Care & Sleep Medicine, The Ohio State University, 2nd Annual Research Day. (September 2007). .

Gavrilin MA, Seshadri S, Hall MW, Wewers MD. "Pyrin, a product of the familial Mediterranean fever gene (MEFV), is associated with IL-1beta processing and release by mononuclear cells infected with Francisella." Proceedings of the American Thoracic Society. (January 2007). A324-.

Seshadri S, Duncan MD, Hart JM, Gavrilin MA, Wewers MD. "Pyrin levels in human monocytes and monocyte-derived macrophages regulate IL-1β processing and release." J.Immunol. (January 2007). 8-.

Gavrilin MA, Wewers MD. "Real Time PCR array modifications allows accurate and inexpensive gene expression evaluation of critically ill patients." DHLRI Research Retreat. (October 2008). 72-.

Gavrilin MA, Wewers MD. "Real Time PCR array modifications allows accurate and inexpensive gene expression evaluation of critically ill patients." Proceedings of the American Thoracic Society. (January 2008). A46-.

Kannan Y, Seshadri S, Mitra S, Gavrilin MA, Wewers MD. "Mail (IkBz) is a key regulator of IL-6 production in response to IL-1β and TLR signaling." DHLRI Research Retreat. (October 2008). 25-.

Hollyfield J, Gavrilin M, Nana-Sinkam P, Wewers M, Exline M. "Smokin’ ICE: Cigarette Smoke Extract Supresses Inflammasome In Peripheral Blood Monocytes Production." DHLRI Research Retreat. (October 2008). 92-.

Butchar JP, Cremer TJ, Clay CD, Gavrilin MA, Wewers MD, Marsh CB, Schlesinger LS, Tridandapani S. "Microarray analysis of human monocytes infected with Francisella tularensis identifies new targets of host response subversion." DHLRI Research Retreat. (October 2008). 70-.

Hollyfield J, Gavrilin M, Nana-Sinkam P, Wewers M, Exline M. "Smokin’ICE: Cigarette smoke extract suppresses inflammasome in peripheral blood monocytes production." Division of Pulmonary, Allergy, Critical Care & Sleep Medicine, The Ohio State University, 3rd Annual Research Day. (September 2008). 36-.

Gavrilin MA, Mitra S, Seshadri S, Berhe F, Wewers MD. "Pyrin regulates Francisella-induced IL-1β processing and release." Center for Microbial Interface Biology. Research Retreat. (September 2008). A30-.

Gavrilin MA, Mitra S, Seshadri S, Berhe F, Hall MW, Wewers MD. "Macrophages are not monocytes in pathogen responses: role of pyrin." . Division of Pulmonary, Allergy, Critical Care & Sleep Medicine, The Ohio State University, 3rd Annual Research Day. (September 2008). 52-.

Butchar JP, Cremer TJ, Clay CD, Gavrilin MA, Wewers MD, Marsh CB, Schlesinger LS, Tridandapani S. "Microarray analysis of human monocytes infected with Francisella tularensis identifies new targets of host response subversion." Center for Microbial Interface Biology. Research Retreat. (September 2008). A18-.

Butchar JP, Cremer TJ, Clay CD, Gavrilin MA, Wewers MD, Marsh CB, Schlesinger LS, Tridandapani S. "Microarray analysis of human monocytes infected with Francisella tularensis identifies new targets of host response subversion." Division of Pulmonary, Allergy, Critical Care & Sleep Medicine, The Ohio State University, 3rd Annual Research Day. (September 2008). 50-.

Hughes TL, Becknel MB, Freud A, Schnidt SE, Yu J, Mao C, Gavrilin M, Wewers M, Caligiuri MA. "The Stage-Specific Effect of Interleukin-1 Beta (IL-1 beta) during Human Natural Killer Cell Development." 50th Annual Meeting of the American- Society-of-Hematology.. (January 2008). 1283-1284.

Seshadri S, Mitra S, Gavrilin MA, Hall MW, Wewers MD. "MAIL (IkBzeta) is a key upstream regulator of monocyte IL-6 production." Keystone symposia “Innate Immunity; Signaling Mechanisms�. (February 2008). .

Gavrilin MA, Seshadri S, Mitra S, Nateri J, Wewers M.D. "Pyrin’s role in endotoxin and Francisella induced IL-1β processing." Keystone symposia “Innate Immunity; Signaling Mechanisms�. (February 2008). .

Hollyfield JL Exline MC, Gavrilin MA, Nana-Sinkam SP, Wewers MD. "Cigarette Smoke Extract Supresses Innate Immune Response In Peripheral Blood Monocytes." Division of Pulmonary, Allergy, Critical Care & Sleep Medicine, The Ohio State University, 4th Annual Research Day. (November 2009). 34-.

Grandhi J, Terentiev D, Wewers MD, Gavrilin MA. "Colocalization of ASC, Caspase-1, and Pyrin Supports Existence of a Pyrin Inflammasome." . Division of Pulmonary, Allergy, Critical Care & Sleep Medicine, The Ohio State University, 4th Annual Research Day. (November 2009). 33-.

Berhe F, Gavrilin MA, Wewers MD. "Macrophages and Monocytes Play a Different Role in Pathogen Response." Division of Pulmonary, Allergy, Critical Care & Sleep Medicine, The Ohio State University, 4th Annual Research Day. (November 2009). 32-.

Akhter A, Gavrilin MA, Frantz L, Washington S, Ditty C, Limoli D, Day C, Sarkar A, Newland C, Butchar J, Marsh CD, Wewers MD, Tridandapani S, Kanneganti TD, Amer AO. "How Caspase-7 Controls Intracellular Infection in Macrophages." Division of Pulmonary, Allergy, Critical Care & Sleep Medicine, The Ohio State University, 4th Annual Research Day. (November 2009). 29-.

Abdelaziz D, Akhter A, Abu Kwaik A, Korange S, Caution K, Gavrilin M, Wewers M, Amer A. "Role of ASC in Legionella pneumophilla infection." Division of Pulmonary, Allergy, Critical Care & Sleep Medicine, The Ohio State University, 4th Annual Research Day. (November 2009). 6-.

Exline MC, Hollyfield JL, Gavrilin MA, Nana-Sinkam SP, Wewers MD. "Cigarette Smoke Extract Supresses Innate Immune Response In Peripheral Blood Monocytes." Proceedings of the American Thoracic Society. (January 2009). A4265-.

Gavrilin MA, Mitra S, Seshadri S, Berhe F, and Wewers MD. "Pyrin enhances IL-1β processing and release in response to Francisella." 6th International Conference on Tularemia. (September 2009). .

Akhter A, Gavrilin MA, Frantz L, Washington S, Ditty C, Limoli D, Day C, Sarkar A, Newland C, Butchar J, Marsh CD, Wewers MD, Tridandapani S, Kanneganti TD, Amer AO. "How Caspase-7 Controls Intracellular Infection in Macrophages." DHLRI Research Retreat. (October 2009). 93-.

Abdelaziz D, Akhter A, Abu Kwaik A, Korange S, Caution K, Gavrilin M, Wewers M, Amer A. "Role of ASC in Legionella pneumophilla infection." DHLRI Research Retreat. (October 2009). 5-.

Zakharova E, Berhe F, Wewers MD, Gavrilin MA. "Control of Mycoplasma contamination in the laboratory." . Division of Pulmonary, Allergy, Critical Care & Sleep Medicine, The Ohio State University, 4th Annual Research Day. (November 2009). 40-.

Gavrilin MA, Seshadri S, Mitra S, Berhe F, Wewers MD. "Pyrin Enhances IL-1β Processing and Release in Response to Francisella." Great Lake Regional Center of Excellence for Biodefense and Emerging Infectious Diseases. 7th Annual Meeting. (December 2009). 14-.

Awomoyi AA, Papp A, Gavrilin M, Sadee W, Wewers M. "Allelic mRNA expression imbalance in inflammation related genes." Keystone symposia “Pattern Recognition Molecules and Immune Sensors of Pathogens�. (April 2009). .

Grandhi J, Zakharova E, Terentyev D, Wewers MD, Gavrilin MA. "Pyrin assembles with ASC and caspase-1 in response to pathogens." Center for Microbial Interface Biology. Research Retreat. (March 2010). A66-.

Akhter A, Gavrilin MA, Frantz L, Washington S, Ditty C, Limoli D, Day C, Sarkar A, Newland C, Butchar J, Marsh CD, Wewers MD, Tridandapani S, Kanneganti TD, Amer AO. "Caspase-7 activation by the IPAF inflammasome restricts Legionella pneumophila infection." Center for Microbial Interface Biology. Research Retreat. (March 2010). A27-.

Abdelaziz D, Akhter A, Abu Kwaik A, Korange S, Caution K, Gavrilin M, Wewers M, Amer A. "Role of ASC in Legionella pneumophilla infection." Center for Microbial Interface Biology. Research Retreat. (March 2010). A19-.

Rahmanian SD, Gavrilin MA, Berhe F, Ferketich A, Wewers ME, Wewers MD, Diaz FT.. "Correlation of inflammatory BAL biomarkers with pulmonary function testing in HIV+ smokers." Proceedings of the American Thoracic Society. (January 2010). .

Zakharova E, Grandhi J, Wewers MD, Gavrilin MA. "Mycoplasma contamination suppresses cells responses to pathogens." Center for Microbial Interface Biology. Research Retreat. (March 2010). A65-.

Gavrilin MA, Mitra S, Berhe F, Grandhi J, Wewers MD. "Role of pyrin inflammasome in IL-1β processing in response to Francisella." Keystone symposia “Innate Immunity: Mechanisms Linking with Adaptive Immunity�. (June 2010). .

Wewers MD, Gavrilin MA. "Pyrin: Unique role in human detection of Francisella." Regional Centers of Excellence for Biodefence and Emerging Infectious Diseases. (April 2011). 206-.

 

Editorial Activities

2006 - present DHLRI Intramural Thematic Grant Program
2007 - present DHLRI Intramural Thematic Grant Program
2009 - present Health Research Bord, Ireland
2009 - present PLoS One
2010 - present The Ohio State University College of Medicine Medical Student Research Scholarship
2010 - present Frontiers in Cellular and Infection Microbiology
2010 - present Chemical Biology & Drug Design
2012 - present World Journal of Immunology
2012 - present Journal of Proteome Research
2012 - present Dataset Papers in Immunology
2012 - present European Journal of Pharmacology
2012 - present Journal of Inflammation
2012 - present SAGE Open
2013 Flanders Research Foundation, Belgium
 

Honors

1985 First Place Award in Belarus National Student Olympiad in Biology.
1985 Diplomat of All Soviet-Union Student Olympiad in Biology.
1989 Award for the Best Research among Young Scientists. Institute of Radiobiology, Belarus Academy of Sciences, Minsk, Belarus.
1995 Academic Merit Award to Visiting Professors. Santiago de Compostela University, Spain.
2006 Best Research Scientist Poster Award. DHLRI.
 

Journal Articles

Gavrilin MA, Luksha GL. "Intracellular glucocorticoid reception in the albino rats tissues during irradiation." Problemi sovremennoi biologii (The problems of modern biology). Vol. 3, (January 1988.): 2-6.

Konoplya EF, Luksha GL, Gavrilin MA. "Effect of radiation on the intracellular reception of glucocorticoids by tissues with various radiosensitivities." Radiobiologiia. Vol. 28, no. 8. (December 1988.): 772-774.

Gavrilin MA, Luksha GL. "The intracellular glucocorticoid receptor cycle during administration of dexamethasone, actinomycin D and cycloheximide." Problemi sovremennoi biologii (The problems of modern biology). Vol. 4, (January 1989.): 177-181.

Konoplya EF, Luksha GL, Detinkin ON, Zhitkovich AV, Gavrilin MA, Montik VI, Filchenkov GN. "The mechanisms of the realization of the effect of glucocorticoids in aging." Fiziol Zh SSSR Im I M Sechenova. Vol. 76, no. 9. (September 1990.): 1224-1230.

Luksha GL, Gavrilin MA, Montik VI, Konoplya EF. "The Postirradiation Disturbances in the System of Intracell Glucocorticoid Reception." Doklady Acad.Nauk Belarusi (Proc Natl Acad Sci Belarus). Vol. 34, no. 10. (October 1990.): 944-946.

Luksha GL, Gavrilin MA, Konoplya EF. "The intracellular cycle of glucocorticoid receptors during gamma irradiation and the administration of dexamethasone, actinomycin D and cycloheximide]omycin D and cycloheximide." Radiobiologiia. Vol. 30, no. 5. (October 1990.): 602-606.

Konoplya EF, Luksha GL, Gavrilin MA, Sechko LK. "The influence of radioecological situation in Belarus on the mechanisms of steroid hormone action in organism." Vesty Acad.Nauk Belarusi. no. 3-4. (January 1992.): 66-72.

Gavrilin MA. "Growth Hormone Receptor." Biology Bulletin Reviews. Vol. 115, no. 6. (June 1995.): 706-713.

Konoplya EF, Luksha GL, Shpak VV, Ladutko EI, Gavrilin MA. "The effect of gamma radiation at low doses on the receptor binding of triiodothyronine in the nuclei of rat liver cells." Radiats Biol Radioecol. Vol. 37, no. 2. (April 1997.): 3-8.

Hsu SC, Gavrilin MA, Tsai MH, Han J, Lai MZ. "P38 Mitogen-activated Protein Kinase Is Involved in Fas Ligand Expression." J Biol Chem. Vol. 274, no. 36. (January 1999.): 25769-25776.

Hsu SC, Gavrilin MA, Lee HH, Wu CC, Han SH, Lai MZ. "NF-kB-dependent Fas ligand expression." Eur J Immunol. Vol. 29, no. 9. (January 1999.): 2948-2956.

Gavrilin MA, Deucher MF, Boeckman F, Kolattukudy PE. "Monocyte Chemotactic Protein 1 upregulates IL-1beta expression in Human Monocytes." Biochem Biophys Res Commun. Vol. 277, no. 1. (October 2000.): 37-42.

Preobrazhensky AA, Dragan S, Kawano T, Gavrilin MA, Gulina IV, Chakravarty L, Kolattukudy PE. "Monocyte chemotactic protein-1 receptor CCR2b is a glycoprotein that has tyrosine sulfation in a conserved extracellular N-terminal region." J Immunol. Vol. 165, no. 9. (November 2000.): 5295-5303.

Gavrilin MA, Mathes LE and Podell M. "Methamphetamine Enhances Cell-Associated Feline Immunodeficiency Virus Replication in Astrocytes." J Neurovirol. Vol. 8, no. 3. (June 2002.): 242-251.

Hall,M,W; Gavrilin,M,A; WEWERS,M,D. "Monocyte IkB alpha/NFkBp50 mRNA ratio in children with multiple organ dysfunction syndrome (MODS) and prolonged monocyte deactivation (PMD)." PEDIATRIC RESEARCH. Vol. 55, no. 4. (April 2004.): 58A-59A.

Elssner A, Duncan M, Gavrilin M, Wewers MD. "A Novel P2X7 Receptor Activator, the Human Cathelicidin-Derived Peptide LL37, Induces IL-1beta Processing and Release.." J Immunol. Vol. 172, (April 2004.): 4987-4994.

Gavrilin MA, Gulina IV, Kawano T, Dragan S, Chakravarti L, Kolattukudy PE. "Site-directed mutagenesis of CCR2 identified amino acid residues in transmembrane helises 1, 2 and 7 important for MCP-1 binding and biological functions." Biochem Biophys Res Commun. Vol. 327, no. 2. (February 2005.): 533-540.

Seshadri,S; Gavrilin,M,A; Hart,J; Duncan,M,D; WEWERS,M,D. "Pyrin expression is suppressed with monocyte to macrophage differentiation." FASEB JOURNAL. Vol. 19, no. 5. (March 2005.): A1445-A1445.

Hall,M,W; Knatz,N,L; Gavrilin,M; Duncan,M,D; WEWERS,M,D. "Monocyte MRNA expression in pediatric multiple organ dysfunction syndrome (MODS): Anti-inflammatory dominance in nonsurvivors." CRITICAL CARE MEDICINE. Vol. 33, no. 12. (December 2005.): A152-A152.

Parsa KV, Ganesan LP, Rajaram MV, Gavrilin MA, Balagopal A, Mohapatra NP, Wewers MD, Schlesinger LS, Gunn JS, Tridandapani S.. "Macrophage pro-inflammatory response to Francisella novicida infection is regulated by SHIP." PLoS Pathogens. Vol. 2, no. 7. (July 2006.): e71-.

Gavrilin MA , Bouakl IJ, Knatz NL, Duncan MD, Hall MW, Gunn JS, Wewers MD.. "Internalization and phagosome escape required for Francisella to induce human monocyte IL-1beta processing and release." Proc Natl Acad Sci U S A. Vol. 103, no. 1. (January 2006.): 141-146.

Montague CR, Hunter MG, Gavrilin MA, Phillips GS, Goldschmidt-Clermont PJ, Marsh CB.. "Activation of estrogen receptor-alpha reduces aortic smooth muscle differentiation." Circ Res. Vol. 99, no. 5. (September 2006.): 477-484.

Seshadri S, Duncan MD, Hart JM, Gavrilin MA, Wewers MD. "Pyrin levels in human monocytes and monocyte-derived macrophages regulate IL-1β processing and release." J Immunol. Vol. 179, no. 2. (July 2007.): 1274-1281.

Hall MW, Gavrilin MA, Knatz NL, Duncan MD, Fernandez SA, Wewers MD. "Monocyte mRNA phenotype and adverse outcomes from pediatric multiple organ dysfunction syndrome." Pediatric Res. Vol. 62, no. 5. (November 2007.): 597-603.

Nicholas C, Batra S., Vargo MA, Voss OH, Gavrilin MA, Wewers MD, Guttridge DC, Grotewold E, and Doseff AI. "Apigenin blocks lipopolysaccharide-induced lethality in vivo and pro-inflammatory cytokine expression by inactivating NF-kB through the suppression of p65 phosphorylation." J Immunol. Vol. 179, no. 10. (November 2007.): 7121-7127.

Butchar JP, Cremer TJ, Clay CD, Gavrilin MA, Wewers MD, Marsh CB, Schlesinger LS, Tridandapani S. "Microarray analysis of human monocytes infected with Francisella tularensis identifies new targets of host response subversion." PLoS ONE. Vol. 3, no. 8. (August 2008.): e2924-.

Fahy RJ, Exline M, Gavrilin MA, Bhatt NY, Bethecker BY, Sarkar A, Hollyfield JL, Duncan MD, Nagaraja HN, Knatz NL, Hall M, Wewers MD. "Inflammasome mRNA expression in human monocytes during early septic shock." Am J Respir Crit Care Med. Vol. 177, no. 9. (May 2008.): 983-988.

Crouser ED, Culver DA, Knox KS, Julian MW, Shao G, Abraham S, Liyanarachchi S, Macre JE, Wewers MD, Gavrilin MA, Ross P, Abbas A, Eng C. "Gene expression profiling identifies MMP-12 and ADAMDEC1 as potential pathogenic mediators of pulmonary sarcoidosis.." Am J Respir Crit Care Med. Vol. 179, no. 10. (May 2009.): 929-938.

Akhter A, Gavrilin MA, Frantz L, Washington S, Ditty C, Limoli D, Day C, Sarkar A, Newland C, Butchar J, Marsh CD, Wewers MD, Tridandapani S, Kanneganti TD, Amer AO. "Caspase-7 Activation by the Nlrc4/Ipaf Inflammasome Restricts Legionella pneumophila Infection." PLoS Pathogens. Vol. 5, no. 4. (April 2009.): e10000361-.

Gavrilin MA, Mitra S, Seshadri S, Nateri J, Berhe F, Hall MW, Wewers MD.. "Pyrin critical to macrophage IL-1β response to Francisella challenge.." J Immunol. Vol. 182, no. 12. (June 2009.): 7982-7989.

Hughes T, Becknell B, Freud AG, McClory S, Briercheck E, Yu J, Mao C, Giovenzana C, Nuovo G, Wei L, Zhang X, Gavrilin MA, Wewers MD, Caligiuri MA. "IL-1beta selectively expands and sustains IL-22(+) immature human natural killer cells in secondary lymphoid tissue." Immunity. Vol. 32, no. 6. (June 2010.): 803-814.

Zakharova E, Grandhi J, Wewers MD, Gavrilin MA.. "Mycoplasma suppression of THP-1 cell TLR responses is corrected with antibiotics." PLoS One. Vol. 5, no. 3. (March 2010.): e9900-.

Gavrilin,M,A; ABDELAZIZ,D; Duprey,A; Mostafa,M; Amer,A; WEWERS,M,D. "ROLE OF PYRIN INFLAMMASOME IN IL-1B PROCESSING IN RESPONSE TO BURKHOLDERIA CEPACIA." INFLAMMATION RESEARCH. Vol. 60, (June 2011.): 38-38.

Gavrilin MA and Wewers MD. "Francisella recognition by inflammasomes: differences between mice and men." Front in Microbio. Vol. 2:11, (February 2011.): -.

Abdulrahman BA, Khweek AA, Akhter A, Caution K, Kotrange S, Abdelaziz DHA, Newland C, Rosales-Reyes R, Kopp B, McCoy K, Montione R, Schlesinger LS, Gavrilin MA, Wewers MD, Valvano MA, Amer AO.. "Autophagy stimulation by Rapamycin suppresses lung inflammation and infection by Burkholderia cenocepacia in a model of cystic fibrosis." Autophagy. Vol. 7, no. 11. (November 2011.): 1359-1370.

Abdelaziz DH*, Gavrilin MA*, Akhter A, Caution K, Kotrange S, Khweek AA, Abdulrahman BA, Zeinab A, Hassan ZA, El-Sharkawi FZ, Bedi SS, Ladner K, Gonzales-Mejia EM, Doseff A, Mostafa M, Devi-Kanneganti T, Guttridge D, Marsh C, Wewers MD, Amer AO.. "Asc-dependent and independent mechanisms contribute to restriction of Legionella ppneumophila infection in murine macrophages.." Front in Microbio. Vol. 2:18, (February 2011.): -.

Abdelaziz DH*, Gavrilin MA*, Akhter A, Caution K, Kotrange S, Khweek AA, Abdulrahman BA, Grandhi J, Hassan ZA, Marsh C, Wewers MD, Amer AO.. "ASC controls Legionella pneumophila infection in human monocytes.." J Biol Chem. Vol. 5, no. 286. (February 2011.): 3203-3208.

Akhter A, Caution K, Abu Khweek A, Tazi M, Abdulrahman BA, Abdelaziz DH, Voss OH, Doseff AI, Hassan H, Azad AK, Schlesinger LS, Wewers MD, Gavrilin MA, Amer AO. "Caspase-11 promotes the fusion of phagosomes harboring pathogenic bacteria with lysosomes by modulating actin polymerization." Immunity. Vol. 37, no. 1. (July 2012.): 35-47.

2. Ghonime MG, Shamaa OR, Eldomany RA, Gavrilin MA, Wewers MD. "Tyrosine phosphatase inhibition induces an ASC-dependent pyroptosis." Biochem Biophys Res Commun. Vol. 425, no. 2. (August 2012.): 384-389.

Gavrilin,Mikhail,A; Abdelaziz,Dalia,HA; Mostafa,Mahmoud; Abdulrahman,Basant,A; Grandhi,Jaykumar; Akhter,Anwari; Abu Khweek,Arwa; Aubert,Daniel,F; Valvano,Miguel,A; Wewers,Mark,D; Amer,Amal,O. "Activation of the Pyrin Inflammasome by Intracellular Burkholderia cenocepacia." JOURNAL OF IMMUNOLOGY. Vol. 188, no. 7. (April 2012.): 3469-3477.

1. Gillette DD, Shah PA, Cremer T, Gavrilin MA, Besecker BY, Sarkar A, Knoell DL, Cormet-Boyaka E, Wewers MD, Butchar JP, Tridandapani S. "Analysis of Human Bronchial Epithelial Cell Proinflammatory Response to Burkholderia cenocepacia Infection: INABILITY TO SECRETE IL-1β." J Biol Chem. Vol. 288, no. 6. (February 2013.): 3691-3695.

 

Presentations

"Consequences of the Chernobyl Catastrophe." Presented at Invited talk, . (June 1994)

"Growth Hormone Receptors." Presented at Seminar, Madrid, ES|ESP. (March 1995)

"Methamphetamine Enhances FIV-MD Replication in Feline Astrocytes." Presented at Section Presentation, San Diego, CA, US|USA. (November 2001)

"Multiple Psychostimulants Enhance FIV-MD Replication and CXCR4 Expression in Feline Astrocytes during Cell-Associated Infection." Presented at Podium presentation, Amelia Island, FL, US|USA. (December 2002)

"Methamphetamine and some other Psychostimulants Enhance FIV-MD Replication in Feline Astrocytes." Presented at Invited talk, Baltimore, MD, US|USA. (June 2002)

"Real Time PCR Array Based on Relative Quantification." Presented at Seminar, Columbus, OH, US|USA. (December 2005)

"Polymerase Chain Reaction." Presented at Educational Seminar for Fellows, . (July 2005)

"Monocytes and Macrophages Differ in Response to Francisella. A Potential Regulatory Role of Pyrin." Presented at Podium presentation, Hilton Head, SC, US|USA. (November 2006)

"Gene Delivery: Cell Biology Tools (Aka: MAGic Tools)." Presented at Educational Seminar, . (March 2007)

"Pyrin, a product of the familial Mediterranean fever gene (MEFV), is associated with IL-1beta processing and release by mononuclear cells infected with Francisella." Presented at Poster Discussion Session, San Francisco, CA, US|USA. (May 2007)

"Chernobyl: 20 years later." Presented at Invited lecture, Columbus, OH, US|USA. (May 2007)

"Some Art at the DHLRI – State of the Art." Presented at Pulmonary Research Conference, Columbus, OH, US|USA. (June 2007)

"Radiation. Effects: Benefits and Danger." Presented at Course PUBH-EHS 733, Columbus, OH, US|USA. (April 2008)

"Real Time PCR Array Based on Relative Quantification." Presented at Guest lecture, Minsk, BY|BLR. (September 2008)

"New Type of Inflammasome – the Pyrin Inflammasome." Presented at Guest lecture, Minsk, BY|BLR. (September 2008)

"The PAPAs of the Pyrin Inflammasome." Presented at Pulmonary Research Conference, Columbus, OH, US|USA. (January 2008)

"Evolution of PCR: from mili to nano in 25 years." Presented at Seminar, . (December 2009)

"New Type of Intracellular Pathogens Sensor – the Pyrin Inflammasome." Presented at Research in Progress, . (January 2009)

"Pyrin Critical to Macrophages IL-1 Response to Francisella Challenge." Presented at Pulmonary Research Conference, . (April 2009)

"Application of the OpenArray Inflammatory Platform." Presented at Seminar: The OpenArray - A Novel Nanofluidic qPCR Technology. Platform Overview and Applications, Columbus, OH, US|USA. (October 2009)

"Critical Players of the Innate Immunity." Presented at Guest lecture, Minsk, BY|BLR. (September 2009)

"Inflammasome Update." Presented at Pulmonary Research Conference, Columbus, OH, US|USA. (September 2010)

"Real-Time PCR - Theory and Practice." Presented at 14 International School of Young Scientists, Puschino. (April 2010)

"Role of Pyrin Inflammasome in IL-1ß Processing in Response to Burkholderia cepacia." Presented at 10th World Congress on Inflammation, Paris, FR|FRA. (June 2011)

"Chernobyl 25th Anniversary. Lesson from Chernobyl for Japan." Presented at Invited lecture, Columbus, OH, US|USA. (April 2011)

 

Professional Activities

2001 - present Society for Neuroscience. San Diego, CA.
2005 - present DHLRI Research Day. The Ohio State University. Columbus, OH.
2006 - present DHLRI Research Day. The Ohio State University. Columbus, OH.
2006 - present Pulmonary Research Day. The Ohio State University. Columbus, OH.
2007 - present School of Medicine Research Day. The Ohio State University. Columbus, OH.
2007 - present Pulmonary Research Day. The Ohio State University. Columbus, OH.
2007 - present CMIB Research Retreat. Columbus, OH.
2007 - present DHLRI Research Day. The Ohio State University. Columbus, OH.
2008 - present CMIB Research Retreat. The Ohio State University. Columbus, OH.
2008 - present Pulmonary Research Day. The Ohio State University. Columbus, OH.
2009 - present Pulmonary Research Day. Columbus, OH.
2009 - present DHLRI Research Day. The Ohio State University. Columbus, OH.
2010 - present School of Medicine Research DAy. The Ohio Sate University. Columbus, OH.
2010 - present CMIB Research Retreat. The Ohio State University. Columbus, OH.
2011 - present DHLRI Research Day. Columbus, OH.
2002 6th International Feline Retrovirus Research Symposium. Amelia Island, FL.
2003 2nd Anual Symposium on the Functional Genomics of Critical Illness and Injury. NIH. Bethesda, MO.
2003 International Meeting of the Institute of Human Virology. Baltimore, MD.
2005 Innate Immunity to Pathogens. Keystone Symposia. Steamboat Springs, CO.
2006 Innate Immunity. Keystone Symposia. Banff, AB.
2007 American Thoracic Society. San Francisco, CA.
2008 American Thoracic Society. Toronto, ON.
2008 Innate Immunity: Signaling Mechanisms. Keystone Symposia. Keystone, CO.
2009 6th International Conference on Tularemia.
2010 Innate Immunity: Mechanisms Linking with Adaptive Immunity. Keystone Symposia.
2011 10th World Congress on Inflammation.
2011 Chernobyl 25th Anniversary. Lesson from Chernobyl for Japan. The Ohio State University.
2011 Regional Centers of Excellence for Biodefense and Emerging Infectious Diseases. Denver, CO.