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Liva Rakotondraibe, PhD


500 W 12th Ave
Columbus, OH 43210

Phone: (614) 292-4733

Email: rakotondraibe.1@osu.edu

 

Current OSU Appointment

Assistant Professor, Pharm CBO/Coll

 

Research Interest

Drug discovery from natural products: higher plants, liverworts, marine organisms, epiphytes, endophytes; Cancer, Malaria, antimicrobials; structure determination of bioactive compounds, Nuclear Magnetic Resonance, Mass, HPLC/MS

Professional Interests Narrative

New natural product sources (new and unidentified fungal and bacterial microorganisms, plant endophytes, new endemic and medicinal plant species, etc.) contain many undiscovered potential bioactive metabolites which can combat the world’s deadly diseases including cancer, malaria, viral infections, and chemoresistance. Thus, their investigation has to be prioritized in order to discover potential drug candidates. My lab focuses on: (1) bioguided isolation, structural elucidation and development of bioactive compounds from natural sources, (2) Drug discovery from Madagascan natural products and (3) drug discovery from ethnomedicine.

Academic Advising

2016 Dahai He, The Ohio State University College of Pharmacy. Graduated 0.
 

Chapters in Books

Liva Harinantenaina. "Tocotrienols in plants:Sources and importance." In Tocptrienols: Vitamin beyond tocopherols. Edited by Ronald Ross Watson and Victor R. Preedy. -. Boca Raton, FL, US|USA: CRC Press, August 2009.

 

Conferences

Liva Harinantenaina and Yoshinori Asakawa. "Search for novel and biologically active compounds from Malagasy liverworts." Procedings of the fourth Indochina conference in Pharmaceutical sciences. (November 2005). 1-.

 

Degrees

1998 None Indicated, University of Antananarivo

2003 Ph.D., Hiroshima University

 

Editorial Activities

2010 - present Natural Product Communications
2011 - present Molecules
2013 - present Journal of Natural Products
2014 - present Bioorganic and Medicinal Chemistry Letters
2014 - present Marine Drugs
2014 - present Phytochemistry Letters
2014 - present Nutrients
2015 - present Planta Medica
2015 - present Fitoterapia
2015 - present Natural Product Research
2015 - present Biochemical Systematics and Ecology
2015 - present Tetrahedron Letters
 

Honors

1999 - 2003 Japanese Government (Mombukagakusho): Ministry of Education, Culture, Sports, Science and Technology (MEXT). Japanese Government.
2005 - 2007 Japanese Society for the Promotion of Science. JSPS.
2016 - present 2016 Deans List. Research Safety.
 

Journal Articles

Liva Harinantenaina, Kasai R., Yamasaki K.. "Ent-kaurane diterpenoid glycosides from Cussonia vantsilana." Phytochemistry. Vol. 61, (October 2002.): 367-372.

Liva Harinantenaina, Asakawa Yoshinori. "Chemical constituents of Malagasy Liverworts, Part II: mastigophoric acid methyl ester of biogenetic interest from Mastigophora diclados." Chem. Pharm. Bull.. Vol. 52, (November 2004.): 1382-13.

Liva Harinantenaina, Yoshiaki Noma and Asakawa Yoshinori. "Penicillium sclerotiorum catalyzes the conversion of Herbertenediol into its dimers: Mastigophorenes A and B." Chem. Pharm. Bull.. Vol. 53, (May 2005.): 256-257.

Liva Harinantenaina, Dang Ngoc Quang, T. Nishizawa, K. Soma, Y. Asakawa. "Bis(bibenzyls) from liverworts inhibit LPS induced iNOS in 264.7 RAW cells." J. Nat. Prod.. Vol. 68, (December 2005.): 1779-1781.

Liva Harinantenaina, Ritsu Kurata, Asakawa Yoshinori. "Chemical constituents of Malagasy liverworts, Part III: Sesquiterpenoids from Bazzania decrescens and Bazzania madagassa." Chem. Pharm. Bull.. Vol. 53, (May 2005.): 515-518.

Liva Harinantenaina and Yoshinori Asakawa. "Malagasy liverworts, source of new and biologically active compounds." Nat. Prod. Comm.. Vol. 2, (June 2006.): 701-709.

Harinantenaina Liva, Sigeru Takaoka. "Cinnafragrin A-C: Two dimeric and a trimeric drimane sesquiterpenoid from Cinnamosma fragrans. Structure revision of Capsicodendrin.." J. Nat. Prod.. Vol. 69, (August 2006.): 1193-1197.

Liva Harinantenaina, Emilienne Mananjarasoa, Kasai R., Yamasaki K.. "A new acetylated eudesmane glucoside from Apodytes dimidiata." Zeitshrift fur die Naturdoshung. Vol. 61b, (February 2006.): 113-115.

Liva Harinantenaina,Yusuke Takahara, Takashi Nashizawa, Chie Kohchi, Gen-Ichiro Soma, Yoshinori Asakawa. "Chemical constituents of Malagasy liverworts Part V: Prenylated bibenzyls and clerodane diterpenes with nitric oxide inhibitory activity from Radula appressa and Thysananthus spathulistipus." Chemical and Pharmaceutical Bulletin. Vol. 54, (July 2006.): 1046-1049.

Niko Radulovic, Emilienne mananjarasoa, Harinantenaina Liva, Y. Asakawa. "Essential oil composition of four Croton species from Madagascar and their chemotaxonomy." Biochem. Syst. Ecol.. Vol. 34, (August 2006.): 648-653.

Yangpeng, Hou, Liva Harinantenaina. "New and Bioactive Natural Products Isolated from Madagascar Plants and Marine Organisms. Current Medicinal Chemistry." Curr. Med. Chem.. Vol. 17, (December 2010.): 1191-1219.

L. Harinantenaina Rakotondraibe, Rado Rasolomampianina, Hyun-Young Park, Jie Li, Carla Slebodnick, Peggy J. Brodie, Leah C. Blasiak, Russell T. Hill, Yongchun Shen, Edward M. Suh, Maria B. Cassera, Felicite Rejo-Fienena, David G.I. Kingston. "Antiproliferative and Antiplasmodial Compounds from Selected Streptomyces species." Bioorganic Medicinal Chemistry Letters. Vol. 25, (December 2015.): 5646–5649-.

L. Harinantenaina Rakotondraibe. "Review of Problems in Organic Structure Determination. A Practical Approach to NMR Spectroscopy." J. Nat. Prod.. Vol. 79, (June 2016.): 0000-0000.

 

Inventions and Patents

Piermarini PM. and Rakotondraibe HLR.. "USE OF SESQUITERPENS AND THEIR ANALOGS AS GREEN INSECTICIDES FOR CONTROLLING DISEASE VECTORS AND PLANT PESTS." filed 2016, (patent pending), and Application No. OSURF T2015-271

Liva Harinantenaina, Yoshinori Asakawa, Katsuyuki Uchida, Orie Mogami. "Hypoglycemic agents containing bitter cucumber extracts, terpenoids isolated from them, and food and pharmaceutical compositions containing them." Issued 2007, (patent granted), and Application No. JP 2005-345319

DGI Kingston, Belen Cassera and Liva Harinantenaina. "Antimalarial phloroglucinol from Mallotus oppositifolius." filed 2012, and Application No. 61/717,824

 

Professional Activities

present American Society of Pharmacognosy Conference. American Society of Pharmacognosy.