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Linda Saif, PhD


1680 Madison Ave
Wooster, OH 44691

Phone: (330) 263-3742

Email: saif.2@osu.edu

 

Current OSU Appointments

Professor, OARDC Food Animal Health

Professor, Veterinary Preventive Medicine

Professor, Food Science & Technology

 

Academic Advising

2011 - present Kyle Scheuer The Ohio State University - OARDC.
2011 - present Marcia Lee The Ohio State University - OARDC.
2013 - present Jeff Ogg The Ohio State University - OARDC.
2013 - present Chun-Ming Lin The Ohio State University - OARDC.
2013 - present Khadija Majid The Ohio State University - OARDC. Bovine Rotaviruses, Fogarty
2013 - present Mikayla Marshall The Ohio State University - OARDC.
2013 - present Kaylie Twarek The Ohio State University - OARDC.
2013 - present Stephanie Neal The Ohio State University.
2014 - present Hui Hu The Ohio State University.
2010 - 2013 Kuldeep Chattha The Ohio State University.
2013 Trent Weber The Ohio State University - OARDC.
2013 Tessa VerStraete The Ohio State University - OARDC.
2013 Ebony Kimble The Ohio State University - OARDC.
 

Books

Saif, L.J., K.W. Theil. Viral Diarrheas of Man and Animals. Boca Raton, FL, US|USA: CRC Press, January 1990.

 

Chapters in Books

Hasoksuz M, Vlasova A, Saif LJ. "Detection of group 2a coronaviruses with emphasis on bovine and wild ruminant strains. Virus isolation and detection of antibody, antigen, and nucleic acid." In SARS and Other Coronaviruses: Strategies and Protocols. Vol. Methods Mol Biol 454. Edited by D. Cavanagh. 43-59. Totowa, NJ, US|USA: Humana Press, January 2008.

Costantini V, Saif LJ. "Viral hazards associated with swine waste: Calicivirus, Rotavirus." In Fate and Transport of Zoonotic Bacterial, Viral and Parasitic Pathogens during Swine Waste Treatment, Storage and Land Application. Vol. 29. -. Ames, IA: Council for Agricultural Science and Technology, January 2008.

Saif LJ, Vannier P, Blancou J. "Transmissible gastroenteritis and porcine respiratory coronavirus disease." In Infectious and Parasitic Diseases of Livestock. Vol. Chapter 45. 549-. Cachan Cedex, FR|FRA: Lavoisier Editions, January 2008.

Leon JS, Souza M, Wang Q, Smith ER, Saif LJ, Moe CL. "Immunology of Norovirus Infection." In Immunity Against Mucosal Pathogens. Edited by Michael Vajdy. 219-262. New York, NY, US|USA: Springer, January 2008.

GonzalezAM, Azevedo MSP, Saif LJ. "Intestinal and systemic immunity to rotavirus in animal models and humans." In Immunity Against Mucosal Pathogens. Edited by Michael Vajdy. 263-297. New York, NY, US|USA: Springer, January 2008.

Saif LJ. "Transmissible gastroenteritis." In OIE Manual of Diagnostic Tests and Vaccines for Terrestial Animals. Vol. Chapter 2.6.4. -. Paris, FR|FRA: OIE, January 2008.

Saif, L.J.. "Bovine Respiratory Coronavirus." In Bovine Respiratory Disease, Veterinary Clinics of North America. Vol. 26. Edited by V.L. Cooper, B.W. Brodersen, RA. Smith. 349-364. Amsterdam: Elsevier, January 2010.

L.J. Saif. "Reoviridae, Coronaviridae." In Fenner’s Veterinary Virology, 4th Edition,. Edited by J. MacLachlan & E. Dubovi. -. The Netherlands: Elsevier, January 2010.

Chang, K.O., Y. Kim and L.J. Saif. "Rotavirus and reovirus." In Diseases of Swine. -. Ames: Wiley-Blackwell Publishing, January 2012.

Saif, L.J., M. Pensaert, K. Sestak, S.G. Yeo and K. Jung. "Coronaviruses." In Diseases in Swine 10th edition. Edited by J.J. Zimmerman, et al,. -. Ames: Blackwell Publishing, January 2012.

Saif, L.J., M. Pensaert, K. Sestak, S.G. Yeo and K. Jung. "Coronaviruses." In Diseases of Swine. -. Ames, IS|ISL: Wiley-Blackwell Publishing, January 2012.

Chang, K.O., Y. Kim and L.J. Saif. "Rotavirus and reovirus." In Diseases of Swine, 10th edition. Edited by J.J. Zimmerman, et al,. -. Ames: Blackwell Publishing, January 2012.

Azevedo, MP, A.N. Vlasova, L.J. Saif. ". Human rotavirus VLP vaccines evaluated in a neonatal gnotobiotic pig model of human rotavirus disease." In Expert Reviews of Vaccines. Vol. 12. 169-181. United Kingdom: Expert Reviews Ltd., December 2013.

Vlasova, A., L.J. Saif. "Biological Aspects of the Interspecies Transmission of Selected Coronaviruses." In Viral Infections and Climate Change. 393-418. Wiley Blackwell Press: John Wiley & Sons, December 2013.

 

Conferences

Saif,L,J. "Animal coronavirus vaccines: Lessons for SARS." CONTROL OF INFECTIOUS ANIMAL DISEASES BY VACCINATION. (January 2004). 129-140.

L.J. Saif, et al.. "Pathogens in rural and agricultural water and watersheds 2010." Participant and Contributor USDA/CSREES National Synthesis Workshop Proceedings. (January 2010). .

L.J. Saif. "Efficacy testing of vaccines for enteric infections: Correlates and concerns for mucosal vaccines." Practical Alternatives to Reduce Animal Testing in Quality Control of Veterinary Biologicals in the Americas. (February 2010). .

 

Honors

2013 OARDC Multi-disciplinary Team Research Award for its efforts to reduce foodborne illnesses caused by fresh produce. The award, which is given every three years, honors research excellence by teams comprised of OARDC scientists from a range of fields.. OARDC Administration.
 

Journal Articles

SAIF LJ; BOHL EH; THEIL KW; CROSS RF; HOUSE JA. "Rotavirus-like Calicivirus-like And 23 Nanometer Virus-like Particles Associated With Diarrhea In Young Pigs." Journal of Clinical Microbiology. Vol. 12, no. 1. (January 1980.): 105-111.

WYATT R, G; JAMES W, D; BOHL E, H; THEIL K, W; SAIF L, J; KALICA A, R; GREENBERG H, B; KAPIKIAN A, Z; CHANOCK R M. "Human Rotavirus Type 2 Cultivation In-vitro." Science (Washington D C). Vol. 207, no. 4427. (January 1980.): 189-191.

THEIL K, W; MCCLOSKEY C, M; SAIF L, J; REDMAN D, R; BOHL E, H; HANCOCK D, D; KOHLER E, M; MOORHEAD P D. "Rapid Simple Method Of Preparing Rotaviral Double Stranded Rna For Analysis By Poly Acrylamide Gel Electrophoresis." Journal of Clinical Microbiology. Vol. 14, no. 3. (January 1981.): 273-280.

RIEPENHOFF-TALTY, M; SAIF, L; BARRETT, H; OGRA P L. "Etiologic Spectrum Of Viral Enteritis In Infants Under 5 Months Of Age." Abstracts of the Annual Meeting of the American Society for Microbiology. Vol. 82, (January 1982.): ABSTRACT C177-.

BOHL E, H; SAIF L, J; THEIL K, W; AGNES A, G; CROSS R F. "Porcine Pararotavirus Detection Differentiation From Rotavirus And Pathogenesis In Gnotobiotic Pigs." Journal of Clinical Microbiology. Vol. 15, no. 2. (January 1982.): 312-319.

SAIF L, J; REDMAN D, R; SMITH K, L; THEIL K W. "Passive Immunity To Bovine Rotavirus In New Born Calves Fed Colostrum Supplements From Immunized Or Nonimmunized Cows." Infection and Immunity. Vol. 41, no. 3. (January 1983.): 1118-1131.

RIEPENHOFF-TALTY, M; SAIF L, J; BARRETT H, J; SUZUKI, H; OGRA P L. "Potential Spectrum Of Etiological Agents Of Viral Enteritis In Hospitalized Infants." Journal of Clinical Microbiology. Vol. 17, no. 2. (January 1983.): 352-356.

SAIF L, J; SMITH K, L; LANDMEIER B, J; BOHL E, H; THEIL K, W; TODHUNTER D A. "Immune Response Of Pregnant Cows To Bovine Rotavirus Immunization." American Journal of Veterinary Research. Vol. 45, no. 1. (January 1984.): 49-58.

BOHL E, H; THEIL K, W; SAIF L J. "Isolation And Serotyping Of Porcine Rotaviruses And Antigenic Comparison With Other Rotaviruses." Journal of Clinical Microbiology. Vol. 19, no. 2. (January 1984.): 105-111.

SAIF L, J; SAIF Y, M; THEIL K W. "Enteric Viruses In Diarrheic Turkey Poults." Avian Diseases. Vol. 29, no. 3. (January 1985.): 798-811.

WOODE G, N; SAIF L, J; QUESADA, M; WINAND N, J; POHLENZ J, F; GOURLEY N K. "Comparative Studies On 3 Isolates Of Breda Virus Of Calves." American Journal of Veterinary Research. Vol. 46, no. 5. (January 1985.): 1003-1010.

THEIL K, W; SAIF L, J; MOORHEAD P, D; WHITMOYER R E. "Porcine Rotavirus-like Virus Group B Rotavirus Characterization And Pathogenicity For Gnotobiotic Pigs." Journal of Clinical Microbiology. Vol. 21, no. 3. (January 1985.): 340-345.

THEIL K, W; SAIF L J. "In-vitro Detection Of Porcine Rotavirus-like Virus Group B Rotavirus And Its Antibody." Journal of Clinical Microbiology. Vol. 21, no. 5. (January 1985.): 844-846.

SAIF L, J; SMITH K L. "Enteric Viral Infections Of Calves And Passive Immunity." Journal of Dairy Science. Vol. 68, no. 1. (January 1985.): 206-228.

NAKATA, S; ESTES M, K; GRAHAM D, Y; LOOSLE, R; TAO, H; SHUSHENG, W; SAIF, L; MELNICK J L. "Antigenic Characterization And Elisa Detection Of Adult Diarrhea Rotaviruses." Journal of Infectious Diseases. Vol. 154, no. 3. (January 1986.): 448-455.

HOBLET K, H; SAIF L, J; KOHLER E, M; THEIL K, W; BECH-NIELSEN, S; STIZLEIN G A. "Efficacy Of An Orally Administered Modified-live Porcine-origin Rotavirus Vaccine Against Postweaning Diarrhea In Pigs." American Journal of Veterinary Research. Vol. 47, no. 8. (January 1986.): 1697-1703.

HOBLET K, H; KOHLER E, M; SAIF L, J; THEIL K, W; INGALLS W L. "Study Of Porcine Postweaning Diarrhea Involving K-88-negative Hemolytic Escherichia-coli." American Journal of Veterinary Research. Vol. 47, no. 9. (January 1986.): 1910-1912.

SAIF L, J; REDMAN D, R; MOORHEAD P, D; THEIL K W. "Experimentally Induced Coronavirus Infections In Calves Viral Replication In The Respiratory And Intestinal Tracts." American Journal of Veterinary Research. Vol. 47, no. 7. (January 1986.): 1426-1432.

TERRETT L, A; SAIF L, J; THEIL K, W; KOHLER E M. "Physicochemical Characterization Of Porcine Pararotavirus And Detection Of Virus And Viral Antibodies Using Cell Culture Immunofluorescence." Journal of Clinical Microbiology. Vol. 25, no. 2. (January 1987.): 268-272.

TERRETT L, A; SAIF L J. "Serial Propagation Of Porcine Group C Rotavirus Pararotavirus In Primary Porcine Kidney Cell Cultures." Journal of Clinical Microbiology. Vol. 25, no. 7. (January 1987.): 1316-1319.

TERRETT L, A; SAIF L J. "Serial Propagation Of Porcine Group C Rotavirus Pararotavirus In Cell Culture." Abstracts of the Annual Meeting of the American Society for Microbiology. Vol. 87, (January 1987.): 322-.

HORZINEK M, C; FLEWETT T, H; SAIF L, J; SPAAN W J, M; WEISS, M; WOODE G N. "A New Family Of Vertebrate Viruses Toroviridae." Intervirology. Vol. 27, no. 1. (January 1987.): 17-24.

SAIF L J. "Development Of Nasal Fecal And Serum Isotype-specific Antibodies In Calves Challenged With Bovine Coronavirus Or Rotavirus." Veterinary Immunology and Immunopathology. Vol. 17, no. 1-4. (January 1987.): 425-440.

WELCH S-K, W; SAIF L, J; RAM S. "Cell-mediated Immune Responses Of Suckling Pigs Inoculated With Attenuated Or Virulent Transmissible Gastroenteritis Virus." American Journal of Veterinary Research. Vol. 49, no. 8. (January 1988.): 1228-1234.

WELCH S-K, W; SAIF L J. "Monoclonal Antibodies To A Virulent Strain Of Transmissible Gastroenteritis Virus Comparison Of Reactivity With Virulent And Attenuated Virus." Archives of Virology. Vol. 101, no. 3-4. (January 1988.): 221-236.

HOSHINO, Y; SAIF L, J; SERENO M, M; CHANOCK R, M; KAPIKIAN A Z. "Infection Immunity Of Piglets To Either Vp3 Or Vp7 Outer Capsid Protein Confers Resistance To Challenge With A Virulent Rotavirus Bearing The Corresponding Antigen." Journal of Virology. Vol. 62, no. 3. (January 1988.): 744-748.

HECKERT R, A; SAIF L J. "Bovine Coronavirus Epidemiology Pathogenesis And Diagnosis." Journal of the American Veterinary Medical Association. Vol. 192, no. 12. (January 1988.): 1774-.

SAIF L, J; TERRETT L, A; MILLER K, L; CROSS R F. "Serial Propagation Of Porcine Group C Rotavirus Pararotavirus In A Continuous Cell Line And Characterization Of The Passaged Virus." Journal of Clinical Microbiology. Vol. 26, no. 7. (January 1988.): 1277-1282.

FLYNN W, T; SAIF L, J; MOORHEAD P D. "Pathogenesis Of Porcine Enteric Calicivirus-like Virus In Four-day-old Gnotobiotic Pigs." American Journal of Veterinary Research. Vol. 49, no. 6. (January 1988.): 819-825.

FLYNN W, T; SAIF L J. "Serial Propagation Of Porcine Enteric Calicivirus-like Virus In Primary Porcine Kidney Cell Cultures." Journal of Clinical Microbiology. Vol. 26, no. 2. (January 1988.): 206-212.

HECKERT R, A; SAIF L, J; MYERS G W. "Development Of Protein A Gold Immunoelectron Microscopy For Detection Of Bovine Coronavirus In Calves Comparison With Elisa And Direct Immunofluorescence Of Nasal Epithelial Cells." Veterinary Microbiology. Vol. 19, no. 3. (January 1989.): 217-232.

SAIF L, J; REDMAN D, R; BROCK K, V; HERBERT R, A; KOHLER E M. "Characterization Of A Coronavirus Associated With An Episode Of Winter Dysentery In Dairy Cattle." Journal of the American Veterinary Medical Association. Vol. 194, no. 12. (January 1989.): 1793-.

PENARANDA M, E; CUBITT W, D; SINARACHATANANT, P; TAYLOR D, N; LIKANONSAKUL, S; SAIF, L; GLASS R I. "Group C Rotavirus Infections In Patients With Diarrhea In Thailand Nepal And England Uk." Journal of Infectious Diseases. Vol. 160, no. 3. (January 1989.): 392-397.

KANG S-Y; SAIF L, J; MILLER K L. "Reactivity Of Vp4-specific Monoclonal Antibodies To A Serotype 4 Porcine Rotavirus With Distinct Serotypes Of Human Symptomatic And Asymptomatic And Animal Rotaviruses." Journal of Clinical Microbiology. Vol. 27, no. 12. (January 1989.): 2744-2750.

SIMKINS R, A; SAIF L, J; WEILNAU P A. "Epitope Mapping And The Detection Of Transmissible Gastroenteritis Viral Proteins In Cell Culture Using Biotinylated Monoclonal Antibodies In A Fixed-cell Elisa." Archives of Virology. Vol. 107, no. 3-4. (January 1989.): 179-190.

SAIF Y, M; SAIF L, J; HOFACRE C, L; HAYHOW, C; SWAYNE D, E; DEARTH R N. "A Small Round Virus Associated With Enteritis In Turkey Poults." Avian Diseases. Vol. 34, no. 3. (January 1990.): 762-764.

KASSUBA, A; SAIF L, J; GREENBERG H B. "Subgroup Classification Of Porcine Group-a Rotaviruses Using Monoclonal Antibodies In An Elisa." American Journal of Veterinary Research. Vol. 51, no. 6. (January 1990.): 938-944.

ROSEN B, I; SAIF L, J; JACKWOOD D, J; GORZIGLIA M. "Serotypic Differentiation Of Group A Rotaviruses With Porcine Rotavirus Gene 9 Probes." Journal of Clinical Microbiology. Vol. 28, no. 11. (January 1990.): 2526-2533.

ROSEN B, I; SAIF L, J; JACKWOOD D, J; GORZIGLIA M. "Hybridization Probes For The Detection And Differentiation Of Two Serotypes Of Porcine Rotavirus." Veterinary Microbiology. Vol. 24, no. 3-4. (January 1990.): 327-340.

HECKER R, A; SAIF L, J; HOBLET K, H; AGNES A G. "A Longitudinal Study Of Bovine Coronavirus Enteric And Respiratory Infections In Dairy Calves In Two Herds In Ohio Usa." Veterinary Microbiology. Vol. 22, no. 2-3. (January 1990.): 187-202.

PARWANI A, V; SAIF L, J; KANG S-Y. "Biochemical Characterization Of Porcine Enteric Calicivirus Analysis Of Structural And Nonstructural Viral Proteins." Archives of Virology. Vol. 112, no. 1-2. (January 1990.): 41-54.

SAIF L J. "A Review Of Evidence Implicating Bovine Coronavirus In The Etiology Of Winter Dysentery In Cows An Enigma Resolved." Cornell Veterinarian. Vol. 80, no. 4. (January 1990.): 303-312.

JIANG B, M; SAIF L, J; KANG S, Y; KIM J H. "Biochemical Characterization Of The Structural And Nonstructural Polypeptides Of A Porcine Group C Rotavirus." Journal of Virology. Vol. 64, no. 7. (January 1990.): 3171-3178.

BENFIELD D, A; SAIF L J. "Cell Culture Propagation Of A Coronavirus Isolated From Cows With Winter Dysentery." Journal of Clinical Microbiology. Vol. 28, no. 6. (January 1990.): 1454-1457.

GOUVEA, V; ALLEN J, R; GLASS R, I; FANG Z-Y; BREMONT, M; COHEN, J; MCCREA M, A; SAIF L, J; SINARACHATANANT, P; CAUL E O. "Detection Of Group B And C Rotaviruses By Polymerase Chain Reaction." Journal of Clinical Microbiology. Vol. 29, no. 3. (January 1991.): 519-523.

TSUNEMITSU, H; SAIF L, J; JIANG, B; SHIMIZU, M; HIRO, M; YAMAGUCHI, H; ISHIYAMA, T; HIRAI T. "Isolation Characterization And Serial Propagation Of A Bovine Group C Rotavirus In A Monkey Kidney Cell Line Ma104." Journal of Clinical Microbiology. Vol. 29, no. 11. (January 1991.): 2609-2613.

QIAN, Y; SAIF L, J; KAPIKIAN A, Z; KANG S, Y; JIANG, B; ISHIMARU, Y; YAMASHITA, Y; OSETO, M; GREEN K Y. "Comparison Of Human And Porcine Group C Rotaviruses By Northern Blot Hybridization Analysis." Archives of Virology. Vol. 118, no. 3-4. (January 1991.): 269-278.

QIAN, Y; JIANG, B; SAIF L, J; KANG S, Y; OJEH C, K; GREEN K Y. "Molecular Analysis Of The Gene 6 From A Porcine Group C Rotavirus That Encodes The Ns34 Equivalent Of Group A Rotaviruses." Virology. Vol. 184, no. 2. (January 1991.): 752-757.

QIAN, Y; JIANG, B; SAIF L, J; KANG S, Y; ISHIMARU, Y; YAMASHITA, Y; OSETO, M; GREEN K Y. "Sequence Conservation Of Gene 8 Between Human And Porcine Group C Rotaviruses And Its Relationship To The Vp7 Gene Of Group A Rotaviruses." Virology. Vol. 182, no. 2. (January 1991.): 562-569.

PARWANI A, V; FLYNN W, T; GADFIELD K, L; SAIF L J. "Serial Propagation Of Porcine Enteric Calicivirus In A Continuous Cell Line Effect Of Medium Supplementation With Intestinal Contents Or Enzymes." Archives of Virology. Vol. 120, no. 1-2. (January 1991.): 115-122.

OJEH C, K; JIANG B, M; TSUNEMITSU, H; KANG S, Y; WEILNAU P, A; SAIF L J. "Reactivity Of Monoclonal Antibodies To The 41-kilodalton Protein Of Porcine Group C Rotavirus With Homologous And Heterologous Rotavirus Serogroups In Immunofluorescence Tests." Journal of Clinical Microbiology. Vol. 29, no. 9. (January 1991.): 2051-2055.

KANG S, Y; SAIF L J. "Production And Characterization Of Monoclonal Antibodies Against An Avian Group A Rotavirus." Avian Diseases. Vol. 35, no. 3. (January 1991.): 563-572.

JIANG B, M; QIAN, Y; TSUNEMITSU, H; GREEN K, Y; SAIF L J. "Analysis Of The Gene Encoding The Outer Capsid Glycoprotein Vp7 Of Group C Rotaviruses By Northern And Dot Blot Hybridization." Virology. Vol. 184, no. 1. (January 1991.): 433-436.

HECKERT R, A; SAIF L, J; MYERS G, W; AGNES A G. "Epidemiologic Factors And Isotype-specific Antibody Responses In Serum And Mucosal Secretions Of Dairy Calves With Bovine Coronavirus Respiratory Tract And Enteric Tract Infections." American Journal of Veterinary Research. Vol. 52, no. 6. (January 1991.): 845-851.

HECKERT R, A; SAIF L, J; MYERS G W. "Mucosal And Systemic Isotype-specific Antibody Responses To Bovine Coronavirus Structural Proteins In Naturally Infected Dairy Calves." American Journal of Veterinary Research. Vol. 52, no. 6. (January 1991.): 852-857.

HECKERT R, A; SAIF L, J; MENGEL J, P; MYERS G W. "Mucosal And Systemic Antibody Responses To Bovine Coronavirus Structural Proteins In Experimentally Challenge-exposed Calves Fed Low Or High Amounts Of Colostral Antibodies." American Journal of Veterinary Research. Vol. 52, no. 5. (January 1991.): 700-708.

HECKERT R, A; SAIF L, J; MENGEL J, P; MYERS G W. "Isotype-specific Antibody Responses To Bovine Coronavirus Structural Proteins In Serum Feces And Mucosa Secretions From Experimentally Challenge-exposed Colostrum-deprived Calves." American Journal of Veterinary Research. Vol. 52, no. 5. (January 1991.): 692-699.

BENFIELD D, A; JACKWOOD D, J; BAE, I; SAIF L, J; WESLEY R D. "Detection Of Transmissible Gastroenteritis Virus Using Complementary Dna Probes." Archives of Virology. Vol. 116, no. 1-4. (January 1991.): 91-106.

Parwani, A. V.; Rosen, B. I.; McRae, M. A.; Saif, L. J.. "Development of cdna probes for typing group A bovine rotaviruses on the basis of Vp4 specificity." Journal of Clinical Microbiology. Vol. 30, no. 10. (January 1992.): 2717-2721.

OJEH C, K; TSUNEMITSU, H; SIMKINS R, A; SAIF L J. "Development Of A Biotin Streptavidin Enhanced Enzyme-linked Immunosorbent Assay Which Uses Monoclonal Antibodies For Detection Of Group C Rotaviruses." Journal of Clinical Microbiology. Vol. 30, no. 7. (January 1992.): 1667-1673.

LUCCHELLI, A; LANCE S, E; BARTLETT P, B; MILLER G, Y; SAIF L J. "Prevalence Of Bovine Group A Rotavirus Shedding Among Dairy Calves In Ohio." American Journal of Veterinary Research. Vol. 53, no. 2. (January 1992.): 169-174.

HOBLET K, H; SHULAW W, P; SAIF L, J; WEISBRODE S, E; LANCE S, E; HOWARD R, R; ANGRICK E, J; REDMAN D R. "Concurrent Experimentally Induced Infection With Eimeria-bovis And Coronavirus In Unweaned Dairy Calves." American Journal of Veterinary Research. Vol. 53, no. 8. (January 1992.): 1400-1408.

TSUNEMITSU, H; JIANG, B; SAIF L J. "Detection Of Group C Rotavirus Antigens And Antibodies In Animals And Humans By Enzyme-linked Immunosorbent Assays." Journal of Clinical Microbiology. Vol. 30, no. 8. (January 1992.): 2129-2134.

SIMKINS R, A; WEILNAU P, A; BIAS, J; SAIF L J. "Antigenic Variation Among Transmissible Gastroenteritis Virus Tgev And Porcine Respiratory Coronavirus Strains Detected With Monoclonal Antibodies To The S Protein Of Tgev." American Journal of Veterinary Research. Vol. 53, no. 7. (January 1992.): 1253-1258.

SCHALLER J, P; SAIF L, J; CORDLE C, T; CANDLER E, JR; WINSHIP T, R; SMITH K L. "Prevention Of Human Rotavirus-induced Diarrhea In Gnotobiotic Piglets Using Bovine Antibody." Journal of Infectious Diseases. Vol. 165, no. 4. (January 1992.): 623-630.

JIANG, B; TSUNEMITSU, H; GENTSCH J, R; GLASS R, I; GREEN K, Y; QIAN, Y; SAIF L J. "Nucleotide Sequence Of Gene 5 Encoding The Inner Capsid Protein Vp6 Of Bovine Group C Rotavirus Comparison With Corresponding Genes Of Group C A And B Rotaviruses." Virology. Vol. 190, no. 1. (January 1992.): 542-547.

JIANG B, M; SAIF L J. "In-vitro Transcription And Translation Of Genomic Rna From A Porcine Group C Rotavirus." Archives of Virology. Vol. 124, no. 1-2. (January 1992.): 181-185.

CORNAGLIA E, M; FERNANDEZ F, M; GOTTSCHALK, M; BARRANDEGUY M, E; LUCHELLI, A; PASINI M, I; SAIF L, J; PARRAUD J, R; ROMAT, A; SCHUDEL A A. "Reduction In Morbidity Due To Diarrhea In Nursing Beef Calves By Use Of An Inactivated Oil-adjuvanted Rotavirus Escherichia-coli Vaccine In The Dam." Veterinary Microbiology. Vol. 30, no. 2-3. (January 1992.): 191-202.

Hussein, H. A.; Parwani, A. V.; Rosen, B. I.; Lucchelli, A.; Saif, L. J.. "Detection of rotavirus serotypes G1, G2, G3, and G11 in feces of diarrheic calves by using polymerase chain reaction-derived cdna probes." Journal of Clinical Microbiology. Vol. 31, no. 9. (January 1993.): 2491-2496.

Saif, L.; Van Cott, J.; Brim, T.; Lunney, J.. "Mucosal immunity evaluated by Elispot to two antigenically related porcine coronaviruses with distinct tissue tropisms." Journal of Immunology. Vol. 150, no. 8 PART 2. (January 1993.): 116A-.

Saif, L.; Hasabe, H.; Chen, W.-K.. "Immunity of human rotaviruses (hrv) assessed in a gnotobiotic (gn) piglet model." Journal of Immunology. Vol. 150, no. 8 PART 2. (January 1993.): 167A-.

Kang, S. Y.; Benfield, D. A.; Gorziglia, M.; Saif, L. J.. "Characterization of the neutralizing epitopes of Vp7 of the Gottfried strain of porcine rotavirus." Journal of Clinical Microbiology. Vol. 31, no. 9. (January 1993.): 2291-2297.

Saif, L. J.; Van Cott, J. L.; Brim, T. A.. "Immunity to transmissible gastroenteritis virus and porcine respiratory coronavirus infections in swine." Veterinary Immunology and Immunopathology. Vol. 43, no. 1-3. (January 1994.): 89-97.

Tsunemitsu, H.; Saif, L. J.. "Antigenic and biological comparisons of bovine coronaviruses derived from neonatal calf diarrhea and winter dysentery of adult cattle." Archives of Virology. Vol. 140, no. 7. (January 1995.): 1303-1311.

Chang, K. O.; Parwani, A. V.; Saif, L. J.. "Comparative nucleotide and deduced amino acid sequence analysis of Vp7 gene of the Ncdv Cody (i-801) strain of group A bovine rotavirus." Archives of Virology. Vol. 140, no. 7. (January 1995.): 1279-1283.

Ward, L. A.; Rosen, B. I.; Yuan, L.; Saif, L. J.. "Pathogenesis of an attenuated and a virulent strain of group A human rotavirus in neonatal gnotobiotic pigs." Journal of General Virology. Vol. 77, no. 7. (January 1996.): 1431-1441.

Parwani, A. V.; Lucchelli, A.; Saif, L. J.. "Identification of group B rotaviruses with short genome electropherotypes from adult cows with diarrhea." Journal of Clinical Microbiology. Vol. 34, no. 5. (January 1996.): 1303-1305.

Tsunemitsu, H.; Jiang, B.; Saif, L. J.. "Sequence comparison of the Vp7 gene encoding the outer capsid glycoprotein among animal and human group C rotaviruses." Archives of Virology. Vol. 141, no. 3-4. (January 1996.): 705-713.

Saif, L. J.; Ward, L. A.; Yuan, L.; Rosen, B. I.; To, T. L.. "The gnotobiotic piglet as a model for studies of disease pathogenesis and immunity to human rotaviruses." Archives of Virology Supplement. no. 12. (January 1996.): 153-161.

Fernandez, F. M.; Conner, M. E.; Parwani, A. V.; Todhunter, D.; Smith, K. L.; Crawford, S. E.; Estes, M. K.; Saif, L. J.. "Isotype-specific antibody responses to rotavirus and virus proteins in cows inoculated with subunit vaccines composed of recombinant Sa11 rotavirus core-like particles (clp) or virus-like particles (vlp)." Vaccine. Vol. 14, no. 14. (January 1996.): 1303-1312.

Chang, K. O.; Parwani, A. V.; Saif, L. J.. "The characterization of Vp7 (g type) and Vp4 (p type) genes of bovine group A rotaviruses from field samples using Rt-pcr and Rflp analysis." Archives of Virology. Vol. 141, no. 9. (January 1996.): 1727-1739.

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Fernandez, F. M.; Conner, M. E.; Hodgins, D. C.; Parwani, A. V.; Nielsen, P. R.; Crawford, S. E.; Estes, M. K.; Saif, L. J.. "Passive immunity to bovine rotavirus in newborn calves fed colostrum supplements from cows immunized with recombinant Sa11 rotavirus core-like particle (clp) or virus-like particle (vlp) vaccines." Vaccine. Vol. 16, no. 5. (January 1998.): 507-516.

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Hasoksuz, M.; Lathrop, S.; Al-dubaib, M. A.; Lewis, P.; Saif, L. J.. "Antigenic variation among bovine enteric coronaviruses (becv) and bovine respiratory coronaviruses (brcv) detected using monoclonal antibodies." Archives of Virology. Vol. 144, no. 12. (January 1999.): 2441-2447.

Guo, M.; Chang, K. O.; Hardy, M. E.; Zhang, Q.; Parwani, A. V.; Saif, L. J.. "Molecular characterization of a porcine enteric calicivirus genetically related to Sapporo-like human caliciviruses." Journal of Virology. Vol. 73, no. 11. (January 1999.): 9625-9631.

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Guo, M.; Hayes, J.; Cho, K. O.; Parwani, A. V.; Lucas, L. M.; Saif, L. J.. "Comparative pathogenesis of tissue culture-adapted and wild-type Cowden porcine enteric calicivirus (pec) in gnotobiotic pigs and induction of diarrhea by intravenous inoculation of wild-type Pec." Journal of Virology. Vol. 75, no. 19. (January 2001.): 9239-9251.

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Chang, K. O.; Vandal, O. H.; Yuan, L.; Hodgins, D. C.; Saif, L. J.. "Antibody-secreting cell responses to rotavirus proteins in gnotobiotic pigs inoculated with attenuated or virulent human rotavirus." Journal of Clinical Microbiology. Vol. 39, no. 8. (January 2001.): 2807-2813.

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Nguyen, T. V.; Iosef, C.; Jeong, K.; Kim, Y.; Chang, K.-O.; Lovgren-Bengtsson, K.; Morein, B.; Azevedo, M. S. P.; Lewis, P.; Nielsen, P.; Yuan, L.; Saif, L. J.. "Protection and antibody responses to oral priming by attenuated human rotavirus followed by oral boosting with 2/6-rotavirus-like particles with immunostimulating complexes in gnotobiotic pigs.." Vaccine. Vol. 21, no. 25-26. (January 2003.): 4059-4070.

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Azevedo, M. S. P.; Yuan, L.; Pouly, S.; Gonzales, A. M.; Jeong, K. I.; Nguyen, T. V.; Saif, L. J.. "Cytokine responses in gnotobiotic pigs after infection with virulent or attenuated human rotavirus." Journal of Virology. Vol. 80, no. 1. (January 2006.): 372-382.

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Costantini, VP; Azevedo, AC; Li, X; Williams, MC; Michel Jr, FC; Saif, LJ. "Effect of different swine waste treatment technologies on detection and viability of swine enteric viruses." Appl Environ Microbiol. (January 2007.): -.

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Martella V, Banyai K, Lorusso E, Bellacicoo AL, Decaro N, Mari V, Saif LJ, Costantini V, Pezzotti G, Lavazza A, Buonavoglia C. "Genetic heterogeneity of porcine enteric caliciviruses identified from diarrhoeic piglets." Virus Genes. Vol. 36, (January 2007.): 365-373.

Zhang W, Azevedo MSP, Wen K, Gonzalez AM, Saif LJ, Li G, Yousef AE, Yuan L. "Probiotic Lactobacillus acidophilus enhances the immunogenicity of an oral rotavirus vaccine in gnotobiotic pigs." Vaccine. Vol. 26, (January 2008.): 3655-3661.

Zhang X, Alekseev K, Jung K, Vlasova A, Hadya N, Saif LJ. "Cytokine responses in porcine respiratory coronavirus-infected pigs treated with corticosteroids as a model for severe acute respiratory syndrome." J Virol. Vol. 82, (January 2008.): 4420-4428.

Zhang W, Wen K, Azevedo MSP, Gonzalez AM, Saif LJ, Li G, Yousef AE, Yuan L. "Lactic acid bacterial colonization and human rotavirus infection influence distribution and frequencies of monocytes/macrophages and dendritic cells in neonatal gnotobiotic pigs." Vet Immunol Immunopath. Vol. 121, (January 2008.): 222-231.

Zhang W, Azevedo MSP, González AM, Saif LJ, Van Nguyen T, Wen K, Yousef AE, Yuan L. "Influence of probiotic Lactobacilli colonization on neonatal B cell responses in a gnotobiotic pig model of human rotavirus infection and disease." Vet Immunol Immunopathol. Vol. 122, (January 2008.): 175-181.

Yuan L, Wen K, Azevedo MSP, Gonzalez AM, Zhang W, Saif LJ. "Virus-specific intestinal IFN-? producing T cell responses induced by human rotavirus infection and vaccines are correlated with protection against rotavirus diarrhea in gnotobiotic pigs." Vaccine. Vol. 26, (January 2008.): 3322-3331.

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Costantini VP, Azevedo AC, Li X, Williams MC, Michel, FC, Saif LJ. "Effect of different swine waste treatment technologies on detection and viability of swine enteric viruses." Appl Environ Microbiol. Vol. 73, (January 2008.): 5284-5291.

Alekseev K, Vlasova A, Jung K, Hasoksuz M, Zhang X, Halpin R, Wang S, Ghedin E, Spiro D, Saif LJ. "Bovine-like coronaviruses isolated from four species of captive wild ruminants are homologous to bovine coronaviruses, based on complete genomic sequences." J Virol. Vol. 82, no. 4. (January 2008.): 12422-12431.

Jung K, Alekseev KP, Zhang X, Cheon DS, Vlasova AN, Saif LJ. "Altered pathogenesis of porcine respiratory coronavirus in pigs due to immunosuppressive effects of dexamethasone: Implications for corticosteroid use in treatment of severe actue respiratory syndrome coronavirus." J Virol. Vol. 81, (January 2008.): 13681-13693.

Vlasova A, Zhang X, Hasoksuz M, Hadya N, Saif LJ. "The two-way antigenic cross-reactivity between SARS-CoV and group 1 animal CoVs is mediated through an antigenic site located in the N-terminal region of the SARS-CoV nucleoprotein." J Virol. Vol. 81, (January 2008.): 13365-13377.

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Vega, C., L. Garaicoechea, D. Rodriguez, L.J. Saif, and F. Fernandez. "Milk supplemented with immune colostrum: Protection against rotavirus diarrhea and modulatory effect on the systemic and mucosal antibody responses in calves experimentally challenged with bovine rotavirus." Vet. Immunol. Immunopath. (January 2009.): -.

Park. SI, D.H. Park, L.J. Saif, Y.J. Jeong, D.J. Shin, Y.H. Chun, S.J. Park, H.J. Kim, M. Hosmillo, H.J. Kwon, M.I. Kang and K.O. Cho. "Development of SYBR green real-time RT-PCR for rapid detection, antitation and diagnosis of unclassified bovine enteric calicivirus." J Virol Methods. Vol. 1, no. 159. (January 2009.): 64-68.

Wen, K., M.S. Azevedo, A. Gonzalez, W. Zhang, L.J. Saif, G. Li, A. Yousef and L. Yuan. "Toll-like receptor and innate cytokine responses induced by lactobacilli colonization and human rotavirus infection in gnotobiotic pigs." Vet Immunol Immunopathol. Vol. 3-4, no. 127. (January 2009.): 304-315.

Ha, , T.P., H.J. Kim, L.J. Saif, Y.J. Jeong, H.H. Kim, H.J. Kwon, S.J. Park, and K.O. Cho. "Sequence analysis of unusual P[7]G5 bovine rotavirus strains reveals evidence of interspecies transmission.." J Clin Microbiol. Vol. 10, no. 47. (January 2009.): 3329-3332.

Jung, K., A. Gurnani, G.J. Renukaradhya and L.J. Saif. "Nitric oxide is elicited and inhibits viral replication in pigs infected with porcine respiratory coronavirus but not porcine reproductive and respiratory syndrome virus." Vet. Immunol. Immunopath.. (January 2009.): -.

Ziemer, C.J., J.M. Bonner, D. Cole, J. Vinje, V. Constantini, S. Goyal, M. Gramer, R. Mackie, X.J. Meng, G. Myers and L.J. Saif. "Fate and transport of zoonotic, bacterial, viral and parasitic pathogens during swine manure treatment, storage, and land application." J Animal Sciences. Vol. 88, (January 2010.): E84-94.

Renukaradhya, G.J., Alekseev, K.P., Jung, K., Y. Fang and L.J. Saif. "Porcine reproductive and respiratory syndrome virus-induced immunosuppression exacerbates the inflammatory response to porcine respiratory coronavirus in pigs." Viral Immunol.. Vol. 23, (January 2010.): 457-466.

Parreno, V., G. Marcoppido, C. Vega, L. Garaicoechea, D. Rodriguez, L.J. Saif, and F. Fernandez. "Milk supplemented with immune colostrum: Protection against rotavirus diarrhea and modulatory effect on the systemic and mucosal antibody responses in calves experimentally challenged with bovine rotavirus.." Veterinary Immunol. Immunopathol. Vol. 136, (January 2010.): 12-27.

Wang, Q., K. Scheuer, Z. Zhang, W. Gebreyes and L.J. Saif. "Characterization and prevalence of new porcine caliciviruses in US swine." Emerging Infectious Diseases. Vol. 17, (January 2011.): 1103-1106.

Vlasova, A., R. Halpin, S. Wang, E. Ghedin, D.J. Spiro, and L.J. Saif. "Molecular characterization of a new alphacoronavirus species associated with mink epizootic catarrhal gastroenteritis (ECG).." J. of Gen. Virol. Vol. 92, (January 2011.): 1369-1379.

Vega, C.G., M. Bok, A. Vlasova, K.S. Chattha, F.M. Fernandez, A. Wigorovitz, V. Parreno, and L.J. Saif. ". IgY Antibodies Protect Against Human Rotavirus Induced Diarrhea in the Neonatal Gnotobiotic Piglet Disease Model." PLoS One. Vol. 7, (March 2012.): e42788-.

Esseili,Malak,A; Wang,Qiuhong; Zhang,Zhenwen; Saif,Linda,J. "Internalization of Sapovirus, a Surrogate for Norovirus, in Romaine Lettuce and the Effect of Lettuce Latex on Virus Infectivity." APPLIED AND ENVIRONMENTAL MICROBIOLOGY. Vol. 78, no. 17. (September 2012.): 6271-6279.

Azevedo, M.S.P., W. Zhang, K. Wen, A.M. Gonzalez, L.J. Saif, A.E. Yousef and L. Yuan. "Lactobacillus acidophilus and Lactobacillus reuteri modulate cytokine responses in gnotobiotic pigs infected with human rotavirus." Beneficial Microbes. (January 2012.): -.

Esseili M., Q.Wang, and L.J. Saif. "Binding of Human GII.4 Norovirus Virus-Like Particles to Carbohydrates of Romaine Lettuce Leaf Cell Wall Materials." Appl. Environ. Microbiol. Vol. 78, (January 2012.): 786-794.

Mullis, L., L.J. Saif, Y. Zhang, X. Zhang, and M.S.P. Azevedo. "Stability of bovine coroanvirus on lettuce surfaces under household refrigeration conditions." Food Microbiology. Vol. 30, (January 2012.): 180-186.

Wang Q., Z. Zhang and L.J. Saif. "A cultivable porcine sapovirus surrogate for human caliciviruses: stability and attachment to lettuce." Appl Environ Microbiol. Vol. 78, (January 2012.): 3932-3940.

Jung,Kwonil; Wang,Qiuhong; Kim,Yunjeong; Scheuer,Kelly; Zhang,Zhenwen; Shen,Quan; Chang,Kyeong-OK; Saif,Linda,J. "The Effects of Simvastatin or Interferon-alpha on Infectivity of Human Norovirus Using a Gnotobiotic Pig Model for the Study of Antivirals." PLOS ONE. Vol. 7, no. 7. (July 2012.): e41619-.

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Harada, S., T. Oka, E. Tokuoka, N. Kiyota , K. Nishimura, Y. Shimada, T. Ueno, S. Ikezawa, T. Wakita, Q. Wang, L.J. Saif and K. Katayama. "A confirmation of sapovirus re-infection gastroenteritis cases with different genogroups and genetic shifts in the evolving sapovirus genotypes, 2002-2011." Arch Virol. Vol. 157, (October 2012.): 1999-2003.

Azevedo, M.S.P., W. Zhang, K. Wen, A.M. Gonzalez, L.J. Saif, A.E. Yousef and L. Yuan. "Lactobacillus acidophilus and Lactobacillus reuteri modulate cytokine responses in gnotobiotic pigs infected with human rotavirus." Beneficial Microbes. Vol. 3, (March 2012.): 33-42.

Chattha, K.S., S. Kandasamy, A.N. Vlasova and L.J. Saif. "Vitamin A deficiency impairs adaptive B and T cell responses to a prototype monovalent attenuated human rotavirus vaccine and virulent human rotavirus challenge in a gnotobiotic piglet model." PLOS One. Vol. 8, no. 12. (January 2013.): e82966-.

Vlasaova, A, K. Chattha, C. Siegismund, S. Kandasamy, and L.J. Saif. "Prenatally acquired vitamin A deficiency alters innate immune responses to human rotavirus in a gnotobiotic pig model." JOURNAL OF IMMUNOLOGY. Vol. 190, (May 2013.): 4742-53.

Vega, C. G. M Bok, A. N. Vlasova, K. S. Chattha, S. Gómez-Sebastián, C. Nuñez, C. Alvarado, R. Lasa, J. M. Escribano, L. L. Garaicoechea, F. M. Fernández, A. Wigdorovitz, L. J. Saif and V. G. Parreño. "Recombinant Monovalent Llama-Derived Antibody Fragments (VHH) to rotavirus VP6 Protect Neonatal Gnotobiotic Piglets Against Human Rotavirus Induced Diarrhea." PLOS Pathogens. Vol. 9, no. 5. (May 2013.): e1003334-.

Iizuka, S., R. Takai-Todaka, H. Ohshiro, M. Kitajima, Q. Wang, L.J. Saif, T. Wakita, M. Noda, K. Katayama and T. Oka. "Detection of multiple human sapoviruses from imported frozen individual clams." Food and Environmental Virology. Vol. 5, (June 2013.): 119-25.

Sisay, Z., Q. Wang, T. Oka and L.J. Saif. "Prevalence and molecular characterization of porcine enteric caliciviruses and first detection of porcine kobuviruses in US swine." Arch Virol. Vol. 158, (July 2013.): 1583-88.

Scheuer, K.A., T. Oka, A. E. Hoet, W.A. Gebreyes, B. Z. Molla, L.J. Saif, and Q. Wang. "Prevalence of porcine noroviruses, molecular characterization of emerging porcine sapoviruses from finisher swine in the United States, and unified classification scheme for sapoviruses." J Clin Microbiol. Vol. 51, (July 2013.): 2344-53.

Vlasova, A.N., K.S. Chattha, S. Kandasamy, G. Rajashekara, and L.J. Saif. "Lactobacillus rhamnosus (GG) and Bifidobacterium lactis (Bb12) colonization promotes intestinal homeostasis and modulates innate immune responses to virulent human rotavirus." PLOS One. Vol. 8, no. 10. (August 2013.): e76962-.

Chattha, K.S., A.N. Vlasova, S. Kandasamy, Z. Liu, G. Rajashekara, and L.J. Saif. "Divergent immunomodulating effects of probiotics on T cell responses to oral attenuated human rotavirus vaccine and virulent human rotavirus infection in a neonatal gnotobiotic piglet disease model." J Immunology. Vol. 191, (September 2013.): 2446-56.

Oka, T., L.J. Saif, and Q. Wang. "Complete genome sequence of the first genogroup II genotype 18 porcine norovirus strain QW125." Genome Announcement. Vol. 1, (January 2013.): e00344-13.

Oka, T., H. Takagi, L.J. Saif, and Q. Wang. "Complete genome sequence of feline calicivirus 2280 strain from the American Tissue Culture Collection." Genome Announcement. Vol. 1, (January 2013.): e00349-13.

Jee, J., A.E. Hoet, M.A. Azevedo, A. Vlasova, S.C. Loerch, C.L. Pickworth, J. Hanson, and L.J. Saif. "Vitamin A effects on antibody responses of feedlot calves intramuscularly vaccinated with bovine coronavirus." AJVR. Vol. 74, (January 2013.): 1353-62.

Amimo, J.O., A.N. Vlasova, and L.J. Saif. "Prevalence, genetic heterogeneity and identification of a potential new VP4 genotype of porcine group C rotaviruses in nursing and weaned piglets in Ohio, USA." Vet Microbiol. Vol. 164, (April 2013.): 27-38.

Amimo, J.O., A.N. Vlasova, and L.J. Saif. "Detection and genetic diversity of porcine group A rotaviruses in historic (2004) and recent (2011/12) swine fecal samples in Ohio, USA: Predominance of G9P[13] genotype in nursing piglets." J Clin Microbiol. Vol. 51, (April 2013.): 1142-51.

Chattha, K.S., A.N. Vlasova, S. Kandasamy, M.A. Esseili, C.S. Siegismund, G. Rajashekara, and L.J. Saif. "Probiotics and colostrum/milk differentially affect neonatal B cell resopnses to oral rotavirus vaccine." Vaccine. Vol. 31, (December 2013.): 1916-1923.

Sosnovtsev, S.V., K. Bok, Q. Wang, L.J. Saif, and K.Y. Green. "Complete genome sequence of GII.4 human norovirus HS191." Genome A. Vol. 1, (January 2013.): e00169-12.

Lee,C.S., C. Lee, J. Marion, Q. Wang, L.J. Saif and J. Lee. "Occurrence of human enteric viruses at freshwater beaches during swimming season and its link to water inflow." Science of the Total Environment. Vol. 472, (January 2014.): 757-766.

Kandasamy, S., K.S. Chattha, A.N. Vlasova, and L.J. Saif. "Prenatal vitamin A deficiency impairs adaptive immune responses to pentavalent rotavirus vaccine (RotaTeq®) in gnotobiotic pig model." Vaccine. Vol. 21, no. 7. (February 2014.): 816-824.

Lee,C.S., C. Lee, J. Marion, Q. Wang, L.J. Saif and J. Lee. ". Occurrence of human enteric viruses at freshwater beaches during swimming season and its link to water inflow." Vet Microbiol. Vol. 168, no. 1. (January 2014.): 202-207.

Takanashi, S., L.J. Saif, J. H. Hughes, T. Meulia, K. Jung, K. A. Scheuer, and Q. Wang. "Failure of propagation of human norovirus in intestinal epithelial cells with microvilli grown in three-dimensional cultures." Arch Virol. Vol. 159, (February 2014.): 257-66.

 

Reference Works

January 2007 Yuan, L., K. Wen, M.S.P. Azevedo, A.M. Gonzalez, W. Zhang, G. Li, and L.J. Saif."Lactobacilli influence intestinal and systemic toll-like receptor (TLR) 2, 3, 9 expression in gnotobiotic pigs infected with human rotavirus (HRV)." .
January 2008 Yuan, L., W. Zhang, K. Wen, M.S.P. Azevedo, A.M. Gonzalez, L.J. Saif, G. Li, A.E. Yousef."Probiotic lactobacilli enhance the immunogenicity and protective efficacy of a live attenuated rotavirus vaccines." .
January 2008 Yuan L, Zhang W, Wen K, Liu F, Azevedo MSP, Saif LJ, Gonzalez AM, Li G, Yousef AE."Mechanism of lactobacilli’s adjuvant effect on enhancing the immunogenicity and protective efficacy of a live attenuated rotavirus vaccine" .
January 2008 Yuan L, Rao S, Li G, Azevedo MSP, Azevedo AC, Saif LJ."Genome sequence analysis of human rotavirus M (G3P1A[8]) strains" .
January 2008 Ha HTP, Saif LJ, Park SI, Jeong YJ, Hosmillo M, Shin DJ, Chun YH, Hyun BH, Kang MI, Cho KO."Sequence analysis of unusual P[7]G5 bovine rotavirus strains reveals evidence for interspecies transmission" .
January 2008 Saif LJ, Souza M, Cheetham S.."Gnotobiotic pig and calf models for human noroviruses (NoVs)" .
January 2008 Saif LJ."Interspecies Transmission of Coronaviruses: Lessons for SARS. SARS, Animal Coronaviruses, Interspecies Transmission." .
January 2008 LI G, Rao S, Azevedo MSP, Saif LJ, Azevedo AC, Zhang W, Hoshino Y, Yuan L."Comparison of genome sequences of virulent, cell-culture adapted and attenuated WA strain human rotaviruses" .
January 2008 Vlasova A, Resque, H, Azevedo MSP, Tang Y, Morein B, Lovgren-Bentsson K, Saif LJ."The effect of polyIC or IFN-α adjuvants on intestinal and systemic rotavirus B-cell responses in gnotobiotic pigs vaccinated with rotavirus-like particles (VLPs)" .
January 2008 Park SI, Park S, Saif LJ, Hyun BH, Jeong YJ, Ha MTP, Hosmilo M, Kang MI, Cho KO."Molecular characterization of G8 and G6 bovine rotaviruses reveals multispecies reassortments in most of the genes" .
January 2008 Jung K, Alekseev K, Tang Y, Lewis P, Zhang X, Saif LJ."Impact of prior infection with porcine reproductive and respiratory syndrome virus (PRRSV) on the severity of porcine respiratory coronavirus (PRCV) pneumonia as a model for SARS respiratory co-infections" .
January 2008 Jung K, Alekseev K, Renukaradhya GJ, Tang Y, Fang Y, Lewis P, Saif LJ."Altered pathogenesis of porcine respiratory coronavirus (PRCV) subsequent to PRRSV infection: Model for effect of respiratory viral co-infections on SARS severity" .
January 2008 Jee J, Azevedo M, Vlasova A, Hoet A, Loerch SC, Pickworth C, Hanson J, Saif LJ."Effect of vitamin A on bovine coronavirus infection, vaccination and immunity in feedlot calves" .
January 2008 Alekseev K, Vlasova A, Jung K, Hasoksuz M, Zhang X, Halpin R, Wang S, Ghedin E, Spiro D, Saif LJ."Bovine-like coronaviruses isolated from captive wild ruminants are homologous to bovine coronaviruses based on complete RNA genomic sequences" .
January 2008 Azevedo MSP, Vlasova A, Resque H, Tang Y, Morein B, Lovgren-Bentsson K, Saif LJ."Effects of polyIC or rIFN-α on the Th1/Th2/Th3 cytokine responses of gnotobiotic pigs inoculated with a rotavirus-like particles (VLP) vaccine" .
January 2008 Azevedo MSP, Jung K, Alekseev K, Vlasova A, Hasoksuz M, Han MG, Zhang X, Saif LJ."Homologous bovine enteric coronavirus induces a distinct serum cytokine profile from heterologous coronaviruses in infected gnotobiotic calves" .
January 2009 Wang, Q., Z. Zhang, and L.J. Saif."Impact of pH on attachment of the enteropathogenic calicivirus porcine sapovirus to lettuce leaves" Vancouver.
January 2009 Vlasova, A.N., M.S.P. Azevedo, H.R. Resque, A.M. Hartzler, and L.J. Saif."The effect of virulent human rotavirus challenge on TLR3 and 4 responses and plasmacytoid dendritic cell distribution in gnotobiotic pigs vaccinated with rotavirus-like particles (VLPs)" Boston.
January 2009 Vega, C., P. Chacana, L. Garaicoechea, D. Rodriguez, H. Terzolo, L.J. Saif, F. Fernandez, and V. Parreno."Egg yolk immunoglobulins: supplement for the preention of RV diarrhea and effect in the development of the immune response in newborn calves" Hamilton Island, Great Barrier Reef.
January 2009 Saif, L.J., K. Jung, G.J. Renukaradhya, and X. Zhang."Respiratory viral co-infections and corticosteroid treatments influence disease, pathology and immunologic responses to a porcine respiratory coronavirus of pigs" Chicago.
January 2009 Saif, L.J.."Gut reactions to rotavirus vaccines in a gnotobiotic piglet disease model: a priming lesson for neonatal mucosal immunity" Madison.
January 2009 Resque, H.R., A.N. Vlasova, M.S.P. Azevedo, A.M. Hartzler, and L.J. Saif."Rotavirus-like particle (CLP) vaccines with/without attenuated rotavirus priming induce heterotypic rotavirus antibody responses but low protection rates to heterotypic rotavirus challenge" Boston.
January 2009 Renukaradhya, G.J., K. Alekseev, K. Jung and L.J. Saif."Distorted immune responses in pigs to porcine respiratory coronavirus previously infected with porcine reproductive and respiratory syndrome virus: a respiratory viral co-infection model" Chicago.
January 2009 Yuan, L., K. Wen, W. Zhang, M.S.P. Azevedo, A.M. Gonzalez, L.J. Saif, and A. Yousef."TCR-gamma/delta T cell responses to lactobacilli intestinal colonization, rotavirus infection and vaccination in neonatal gnotobiotic pigs." Taos.
October 2010 Jung, K., Q. Wang, Z. Zhang, S. Takanashi, K. Scheuer, Q. Shen, Y. Kim, K.O. Chang, and L.J. Saif.."Simvastatin enhances GII.4 human norovirus infectivity in gnotobiotic pigs." Santa Cruz. : Abst.
December 2010 Chattha, K.S., A. Vlasova, C. Siegismund, N. Chen, and L.J. Saif."Preliminary investigation of B cell immune responses to rotavirus in vitamin A deficient piglets." . : Abst.
January 2010 Louge Uriarte, E., G. V. Parreño, E. Späth, M. R. Leunda, L. J. Saif, A.C. Odeón."Circulacion de rotavirus and coronavirus bovine and terneros de tambo y cria con y sin diarrhea (2007-2009)." Buenos Aires. : Abst.
July 2010 Mullis, LB., L.J. Saif, and M.P. Azevedo."Stability of bovine coronavirus on lettuce surfaces under household refrigeration conditions" Bozeman. : Abst. #W16
October 2010 Wang, Q., K. Scheuer, Z. Zhang, W. Gebreyes and L.J. Saif."Characterization and prevalence of new porcine caliciviruses in US swine." Santa Cruz. : Abst.
October 2010 Takanashi, S., Q.H. Wang, K. Jung, Z. Zhang, N. Chen, Q. Shen, Q., and L.J. Saif."Prolonged virus shedding in an immunocompetent child in a GII.12 human norovirus outbreak" Santa Cruz. : Abst.
February 2010 Saif, L.J.."Efficacy and potency testing of vaccines for enteric pathogens: correlates and concerns for mucosal vaccines" Buenos Aires.
July 2010 Vlasova, A.N., R. Halphi, S. Wang, E. Ghedin, D. Spiro and L.J. Saif."Molecular characterization of a coronavirus associated with mink epizootic catarrhal gastroenteritis" Bozeman. : Abst. #W16
July 2011 Pinto, P., Q. Wang, N. Chen, and L. J. Saif."A novel feline calicivirus clusters in genogroup IV noroviruses" Minneapolis. : Abst. W26
July 2011 Mullis, L., J. Britt, C. Silva, X. Zhang, and L.J. Saif, R. Steele and M.S.P. Azevedo."Prevalence of recently circulating coronaviruses in domestic animals and wildlife in Arkansas USA" Minneapolis. : Abst.
July 2011 Martella, V., E. Lorusso, Q. Wang, P. Pinto, P. Moschidou, A.L. Bellacicco, V. Larocca, N. Decaro, L.J. Saif, and C. Buonavoglia."Canine Vesiviruses" Minneapolis. : Poster P18
July 2011 Esseili, M. A., Q. Wang, Z. Zhang, and L. J. Saif."Persistence and mode of transmission of sapovirus, a surrogate for norovirus, in leafy greens." Minneapolis. : Poster P37
July 2011 Chattha, K.S., A.N. Vlasova, C.S. Siegismund, and L.J. Saif."Vitamin A deficiency affects serum antibody responses to rotavirus vaccination and challenge in a gnotobiotic piglet model" Paris. : Abst.
December 2011 Saif, L.J., A. Vlasova, K. Chattha and S. Kandasamy."Gut reactions to rotavirus vaccines in neonates: Overcoming obstacles to improve efficacy" Chicago.
June 2011 Vlasova, A., R. Halpin, S. Wang, E. Ghedin, D. Spiro, D., and L.J. Saif."Molecular characterization of a new alphacoronavirus species associated with mink epizootic catarrhal gastroenteritis" Acme. : Abst.
May 2011 Lee, C.S., C. Lee, Q. Wang, L.J. Saif and J. Lee."Monitoring of human adenovirus, enterovirus and norovirus in Ohio inland beaches" New Orleans. : Abst.
April 2011 Takanashi, S., N. Chen, Q.H. Wang, K. Jung, Z. Zhang, and L.J. Saif."Prolonged virus shedding in an immunocompetent child in a GII.g/GII.12 human norovirus outbreak" Denver. : Abst
July 2011 Wang, Q., Z. Zhang, and L. J. Saif."Validation of tissue culture-adapted porcine sapovirus as an improved surrogate for human norovirus to assess viral stability and decontamination methods" Minneapolis. : Poster P18
July 2011 Takanashi, S., K. Chattha, M. Khatri, K. Jung, A. Vlasova, K. Scheuer, L.J. Saif, and W. Wang."Attempts to propagate human noroviruses in porcine small intestinal enterocytes and hematopoietic lineage cells" . : Poster P18
July 2011 Silva, C., L. Mullis, R. Owens, L.J. Saif, D. Taylor, L. Haynes, X. Zhang and M.S.P. Azevedo."Human respiratory coronaviruses circulating during the influenza season in Arkansas" Minneapolis. : Abst.
July 2011 Scheuer, K. A., Q. Wang, A. E. Hort, W. A. Gebreyes, B. Z. Molla, and L. J. Saif."Prevalence of noroviruses in US finisher swine" Minneapolis. : Abst. W26
September 2011 Saif, L.J..". Enteric food and waterborne pathogens. Plenary: Noroviruses and food safety: Epidemiology, surrogates and animal model" Addis Ababa.
July 2012 Jung, K., K. Scheuer, Z. Zhang, Q. Wang and L.J. Saif."Pathogenesis of bovine norovirus GIII.2 strain CV186-OH/00/US in gnotobiotic calves" Madison. : Abst.
July 2012 Esseili MA, Wang, Q., Z. Zhang and L.J. Saif."Enhanced persistence of a food-borne enteric calicivirus in/on physically damaged lettuce" Madison. : Abst.
July 2012 Chen, N., Q. Wang, Z. Zhang, P. Pinto, M. Yokoyama, and L.J. Saif."Molecular mechanism of cell culture adaptation of porcine sapovirus" Madison. : Abst.
July 2012 Amimo, J., A. Vlasova and L.J. Saif."Prevalence and diversity of group A and non-group A porcine rotaviruses in selected US farms" Madison. : Abst.
July 2012 Parreno, V., D. Rodriguez, A. Badaracco, I. Nunez, E.L. Uriarte, R. Galarza, G. Bilbao, P. Brandao, L.J. Saif, and F. Fernandez."Bovine coronavirus detected in diarrheic calves in beef and dairy herds from Argentina from 1994 to 2010" Madison. : Abst.
July 2012 Oka, T., H. Takagi, M. Miki, K. Murakami, Y. Tohya, T. Wakita, L.J. Saif and K. Katayama."Development of plasmid DNA transfection-based reverse genetics system for feline calicivirus" Madison. : Abst.
July 2012 Oka, T., E. Tokuoka, K. Naoko, K. Nishimura, Y. Shimada, T. Ueno, S. Ikezawa, T. Wakita, K. Katayama, L.J. Saif. And S. Harada."Nine year sapovirus surveillance reveals clear geneotype shift and presence of re-infection gastroenteritis cases with different genogroups" Madison. : Abst.
July 2012 Kandasamy, S., K.S. Chattha, A. Vlasova, G. Rajashekara and L.J. Saif."Probiotics augment B cell responses to oral rotavirus vaccine in neonatal gnotobiotic pigs" Madison. : Abst.
December 2012 Vlasova, A.N., K.S. Chattha, S. Kandasamy, C.S. Siegismund and L.J. Saif."Vitamin A deficiency alters innate immune responses to human rotavirus in gnotobiotic pigs" San Juan.
March 2012 Takanashi S., L.J. Saif, J.H. Hughes, T. Meulia, K. Jung, K. Scheuer, and Q. Wang."Attempts to propagate human noroviruses in three-dimensional cell cultures." Lubeck.
December 2012 Kandasamy, S., K.S. Chattha, A.N. Vlasova, C.S. Siegismund, and L.J. Saif."Vitamin A deficiency impairs antibody responses to human rotavirus vaccines and protection in a neonatal gnotobiotic piglet model" San Juan.
December 2012 Chattha, K.S., A.N. Vlasova, S. Kandasamy and L.J. Saif."Probiotics modulate T cell and cytokine responses to oral rotavirus vaccine and challenge in a neonatal gnotobiotic piglet model" San Juan.
May 2012 Chattha, K.S., Vlasova, A., Esseili, M., Siegismund, C., Kandasamy, S., Rajashekara, G., Saif, L.J.."Probiotics and lactogenic immune factors affect neonatal B cell responses to rotavirus vaccine" Boston.
July 2013 Chattha, K.S., S. Kandasamy, A.N. Vlasova, and L.J. Saif."16th Intl. Congress on Mucosal Immunology" Vancouver.
August 2013 Saif, L.J., A. Vlasova, K. Chattha and S. Kandasamy."2nd International Congress on Pathogens at the Human-Animal Interface (ICOPHAI): One Health for Sustainable Development" Porto de Galinhas.
July 2013 Kandasamy, S., K.S. Chattha, A.N. Vlasova, G. Rajashekara, and L.J. Saif."16th Intl. Congress on Mucosal Immunology" Vancouver.
March 2013 Saif, LJ."Infant Immunity Grantees Workshop and Meeting" Bethesda.
May 2013 Saif, L.J., K.S. Chattha, S. Kandasamy, C.S. Siegismund, and A.N. Vlasova."Immunology 2013, AAI Annual Meeting" Honolulu. : P6145
May 2013 Kumar, A., A. N. Vlasova, Z. Liu, K.S. Chattha, S. Kandasamy, M. Esseili , X. Zhang, L.J. Saif and G. Rajashekara.". Public Health Preparedness for Infectious Diseases (PHPID) mtg" Columbus.
December 2013 Saif, LJ."CRWAD" Chicago.
July 2013 Wang, Q., Z. Sisay, T. Oka and L.J. Saif."Prevalence and molecular characterization of porcine enteric caliciviruses and first detection of porcine kobuviruses in US Swine" State College. : P25
July 2013 Vlasova, A.N., K.S. Chattha, S. Kandasamy, Z. Liu, M. Esseili, G. Rajashekara, L.J. Saif."Lactobacilli and Bifidobacteria promote immune homeostasis and modulate innate immune responses to human rotavirus vaccine and challenge in neonatal gnotobiotic pigs" Bethesda. : 76
October 2013 Oka, T., G.T. Stoltzfus, C. Zhu, K. Jung, Q Wang, and L.J. Saif."Attempts to grow human and animal noroviruses in vitro" Bejing. : P
October 2013 Lu, Z., K. Jung, T. Oka, Q. Wang, and L.J. Saif.."Comparative pathogenesis of tissue culture porcine sapovirus Cowden strain and infectious clone mutants in gnotobiotic pigs" Bejing. : P
October 2013 Wang, Q., K.A. Scheuer, T. Oka, A.E. Hoet, W.A. Gebreyes, B.Z. Molla, and L.J. Saif."Molecular characterization of emerging porcine sapoviruses from finisher swine in the United States, and unified classification scheme for sapoviruses" Beijing. : 2
August 2013 Saif, L.J., A.N. Vlasova, K.S. Chattha, and S. Kandasamy."Prenatally acquired Vitamin A deficiency alters innate and antibody immune responses and reduces rotavirus vaccine efficacy in a gnotobiotic piglet model" Porto de Galinhas.
December 2013 Wang, Q., T. Oka, M. Esseili, S. Sommer-Wagner, T. Meulia, Y. Zhang, and L.J. Saif."Isolation and characterization of porcine epidemic diarrhea virus (PEDV) for development of serologic tests and vaccine" Chicago.

Presentations

"Emerging Zoonotic Diseases symposium." Presented at National Institutes of Health Symposium, Bethesda, MD. (June 2013)

"SARS/MERS Coronavirus Symposium." Presented at National Institute of Health Meeting, Bethesda, MD. (June 2013)

"Lactobacillus rhamnosus GG and Bifidobacterium animalis subsp. lactis Bb12 probiotics modulate rotavirus diarrhea and immune responses to a human rotavirus vaccine in a neonatal gnotobiotic piglet model." Presented at Infant Immunity Grantees Workshop and Meeting, NIH, Bethesda, MD. (March 2013)

"Coronavirus Natural History." Presented at MERS-CoV Research: Current Topics and Future Priorities NIH, Bethesda, MD. (June 2013)

"Animal Coronaviruses: Lessons for SARS and MERS." Presented at Forum on Microbial Threats: Briefing on Emerging Viral Diseases, IOM, NAS, Bethesda, MD. (June 2013)

"Lactobacilli and Bifidobacteria promote immune homeostasis and modulate innate immune responses to human rotavirus vaccine and challenge in neonatal gnotobiotic pigs." Presented at Human Microbiome Symposium, NIH, Bethesda, MD. (July 2013)

"Impact of vitamin A deficiency and probiotics on vaccination and infection with rotavirus in the germ-free pig model." Presented at Dept. Veterinary Public Health & Food Safety Istituto Superiore di Sanità, Rome, IT|ITA. (September 2013)

"Animal Coronaviruses: Interspecies transmission and lessons for SARS and MERS Coronaviruses." Presented at United Nations, Food, Agriculture Organization (FAO) Headquarters with video link to Affiliates, Rome, IT|ITA. (September 2013)

"Prenatally acquired vitamin A deficiency alters innate immune responses to human rotavirus in a gnotobiotic pig model." Presented at American Association of Immunologists, Honolulu, HI. (May 2013)

"Gut reactions to rotavirus vaccines: Strategies to improve." Presented at , Intl. Congress of Pathogens at the Human-Animal Interface (ICOPHAI), Recife, BR|BRA. (August 2013)

"Prenatally acquired Vitamin A deficiency alters innate and antibody immune responses and reduces rotavirus vaccine efficacy in a gnotobiotic piglet model." Presented at 2nd International Congress on Pathogens at the Human-Animal Interface (ICOPHAI): One Health for Sustainable Development, Recife, BR|BRA. (August 2013)

"The ABCs of swine rotavirus infections." Presented at Institute of Animal Husbandry and Veterinary Science, Agriculture Academy of Hubei province, Wuhan, CN|CHN. (October 2013)

"Animal Coronaviruses: Interspecies transmission and lessons for human Coronaviruses." Presented at , Institute of Animal Husbandry and Veterinary Science, Agriculture Academy of Hubei province, Wuhan, CN|CHN. (October 2013)

", Intestinal ecological niches of enteric viruses influence their pathogenesis and diarrhea severity." Presented at Conference of Research Workers in Animal Diseases, Chicago, IL. (December 2013)

 

Professional Activities

present Annual Reviews, Animal & Veterinary Biosciences Editorial Board. Palo Alto, CA.
present Conference on non-replicating rotavirus vaccine candidates PATH. Bill and Melinda Gates Foundation.
present USDA NIFA Food Virology Collaborative (NoroCORE) meeting. Atlanta, GA.
present NAS Annual Meeting (Section 61 Chair). NAS. Washington, DC.
present NAS, Class Membership Committee Meeting, Western Regional NAS meeting. Irvine, CA.
present Annual Reviews Animal Biosciences Editorial Board. Botega Bay, CA.
present National Academy of Sciences and PNAS Editorial Board Annual Meetings. NAS. Washington, DC.
present Linda Saif. International Conference on Caliciviruses.
present International Veterinary Immunology Symposium.
present Infectious Diseases of Concern to Captive and Free Ranging Animals in North America, 2nd ed. 2013. Infectious Disease Committee, American Association of Zoo Veterinarians, Gamble, K.C.& M.M. Clancy (eds).. Yulee, FL.
present American Association of Immunologists. AAI. Hononlulu, HI.
present Plant and Animal Genome XX Meeting. San Diego, CA.
2009 - present NC1041 Enteric Diseases of Swine and Cattle: Prevention, Control and Food Safety. NC1041. Chicago, IL.
2010 Symposium "Practical Alternatives to Reduce Animal Testing in Quality Control of Veterinary Biologicals in the Americas".
2010 CMIB Annual Meeting DHLRI. OSU Medical Center. Columbus, OH.
2010 National Synthesis Workshop: Pathogens (Bacteria, Viruses and Protozoa) in Rural and Agricultural Water and Watersheds, Cornell University. USDA/CSREES. Ithaca, NY.
2010 National Foundation for Infectious Diseases,. 13th Annual Conference on Vaccine Research. Bethesda, MD.
2010 Oral vaccination response in developing countries and the intestinal microbiome. NIH Conference.
2010 Second Global Conference of OIE, Head of OIE Reference Lab. OIE.
2010 4th Intl. Calicivirus Symposium.
2010 American Association of Immunologists 97th Annual Meeting. AAVI. Baltimore, MD.
2010 American Society of Virology Meeting and Satellite Meetings. ASV. Bozeman, MT.
2010 2010 International Symposium on Important Zoonoses.
2010 Gut integrity in the developing world. Bill and Melinda Gates Foundation. Seattle, WA.
2011 Intl Congress Mucosal Immunology meeting (ICMI).
2009 - 2012 Class Membership Committee Mtg, Western Regional NAS meeting, Class 61, Chair. National Academies of Science.
2009 - 2012 NAS Annual Meeting.
 

Technical Reports

Wang, Q., Z. Zhang, and L.J. Saif. Norovirus nucleotide sequence, human norovirus HS194 strain. Genbank accession #GU325839. Bethesda, MD: (January 2010).

Wang, Q., Z. Zhang, and L.J. Saif. Calicivirus nucleotide sequence, porcine calicivirus WGP93C strain. Genbank accession # GU592498. Bethesda, MD: (January 2010).

Vlasova, A. and L.J. Saif. Molecular characterization of a new alphacoronavirus species associated with mink epizootic catarrhal gastroenteritis. Genbank MCoV WD1127, acc# HM245925, and MCoV WD1133, acc# HM245926. Bethesda, MD: (January 2010).