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Linda Saif, PhD


1680 Madison Ave
Wooster, OH 44691

Phone: (330) 263-3742

Email: saif.2@osu.edu

 

Current OSU Appointments

Professor, OARDC Food Animal Health

Professor, Veterinary Preventive Medicine

Professor, Food Science & Technology

 

Academic Advising

2014 - present John Blankenship, The Ohio State University.
2014 - present Juliet Chepngeno, The Ohio State University.
2011 Marcia Lee, The Ohio State University - OARDC. Graduated 0.
2013 Chun-Ming Lin, The Ohio State University - OARDC. Graduated 0.
2013 Stephanie Neal, The Ohio State University. Graduated 0.
2014 Moyasar Abdulhameed, The Ohio State University. Graduated 0.
2015 Francine Chimelopaim, The Ohio State University. Graduated 0.
2015 Kathryn Anderson, The Ohio State University. Graduated 0.
2016 Kattie McGrath, The Ohio State University. Graduated 0.
2010 - 2013 Kuldeep Chattha, The Ohio State University. Graduated 0.
2013 Tessa VerStraete, The Ohio State University - OARDC. Graduated 0.
2013 Ebony Kimble, The Ohio State University - OARDC. Graduated 0.
2013 - 2014 Mikayla Marshall, The Ohio State University - OARDC. Graduated 0.
2013 - 2014 Kaylie Twarek, The Ohio State University - OARDC. Graduated 0.
2013 - 2014 Jeff Ogg, The Ohio State University - OARDC.
2013 - 2014 Khadija Majid, The Ohio State University - OARDC. Bovine Rotaviruses, Fogarty
2011 - 2015 Kyle Scheuer, The Ohio State University - OARDC. Graduated 0.
2013 - 2015 Abdul Rauf, The Ohio State University. Graduated 2011.
2013 - 2015 Trent Weber, The Ohio State University - OARDC.
2014 - 2015 Paige McAtee, The Ohio State University. Graduated 0.
2014 - 2015 Bryan Eyerly, University of Findlay. Graduated 0. Pre-vet
2014 - 2016 Hui Hu, The Ohio State University. Graduated 0.
 

Books

Viral Diarrheas of Man and Animals

 

Chapters in Books

Detection of group 2a coronaviruses with emphasis on bovine and wild ruminant strains. Virus isolation and detection of antibody, antigen, and nucleic acid.

Viral hazards associated with swine waste: Calicivirus, Rotavirus

Transmissible gastroenteritis and porcine respiratory coronavirus disease

Immunology of Norovirus Infection

Intestinal and systemic immunity to rotavirus in animal models and humans

Transmissible gastroenteritis

Bovine respiratory coronavirus.

Reoviridae, Coronaviridae

Rotavirus and reovirus

Coronaviruses

Coronaviruses

Rotavirus and reovirus

Biological Aspects of the Interspecies Transmission of Selected Coronaviruses

Human rotavirus virus-like particle vaccines evaluated in a neonatal gnotobiotic pig model of human rotavirus disease

Biological Aspects of the Interspecies Transmission of Selected Coronaviruses

Mucosal Veterinary Vaccines: Comparative Vaccinology

Strategies for design and application of enteric viral vaccines.

Gnotobiotic neonatal pig model of rotavirus infection and disease

Probiotics for immunomodulation and treatment of immunological disorders in children: Evaluation in a gnotobiotic animal model

 

Conferences

Animal coronavirus vaccines: lessons for SARS.

Pathogens in rural and agricultural water and watersheds 2010

Efficacy testing of vaccines for enteric infections: Correlates and concerns for mucosal vaccines

Prenatally acquired 2vitamin A deficiency alters innate immune responses to human rotavirus in a gnotobiotic pig model

 

Honors

2013 OARDC Multi-disciplinary Team Research Award for its efforts to reduce foodborne illnesses caused by fresh produce. The award, which is given every three years, honors research excellence by teams comprised of OARDC scientists from a range of fields.. OARDC Administration.
2015 Wolf Prize in Agriculture. Wolf Foundation, Jerusalem.
2017 Fellow by the National Academy of Inventors. National Academy of Inventors.
 

Journal Articles

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"SERIAL PROPAGATION OF PORCINE GROUP-C ROTAVIRUS (PARAROTAVIRUS) IN A CONTINUOUS CELL-LINE AND CHARACTERIZATION OF THE PASSAGED VIRUS." JOURNAL OF CLINICAL MICROBIOLOGY. Vol. 26, no. 7. (July 1988.): -.

"REACTIVITY OF VP4-SPECIFIC MONOCLONAL-ANTIBODIES TO A SEROTYPE-4 PORCINE ROTAVIRUS WITH DISTINCT SEROTYPES OF HUMAN (SYMPTOMATIC AND ASYMPTOMATIC) AND ANIMAL ROTAVIRUSES." JOURNAL OF CLINICAL MICROBIOLOGY. Vol. 27, no. 12. (December 1989.): -.

"Protection and antibody responses to oral priming by attenuated human rotavirus followed by oral boosting with 2/6-rotavirus-like particles with immunostimulating complexes in gnotobiotic pigs.." Vaccine. Vol. 21, no. 25-26. (September 2003.): -.

"Antibody responses to human rotavirus (HRV) in gnotobiotic pigs following a new prime/boost vaccine strategy using oral attenuated HRV priming and intranasal VP2/6 rotavirus-like particle (VLP) boosting with ISCOM.." Clinical and experimental immunology. Vol. 135, no. 3. (March 2004.): -.

"Seroepidemiology of Middle East respiratory syndrome (MERS) coronavirus in Saudi Arabia (1993) and Australia (2014) and characterisation of assay specificity." EUROSURVEILLANCE. Vol. 19, no. 23. (June 2014.): -.

 

Reference Works

January 2007 Yuan, L., K. Wen, M.S.P. Azevedo, A.M. Gonzalez, W. Zhang, G. Li, and L.J. Saif."Lactobacilli influence intestinal and systemic toll-like receptor (TLR) 2, 3, 9 expression in gnotobiotic pigs infected with human rotavirus (HRV)." .
January 2008 Saif LJ, Souza M, Cheetham S.."Gnotobiotic pig and calf models for human noroviruses (NoVs)" .
January 2008 Vlasova A, Resque, H, Azevedo MSP, Tang Y, Morein B, Lovgren-Bentsson K, Saif LJ."The effect of polyIC or IFN-α adjuvants on intestinal and systemic rotavirus B-cell responses in gnotobiotic pigs vaccinated with rotavirus-like particles (VLPs)" .
January 2008 Yuan, L., W. Zhang, K. Wen, M.S.P. Azevedo, A.M. Gonzalez, L.J. Saif, G. Li, A.E. Yousef."Probiotic lactobacilli enhance the immunogenicity and protective efficacy of a live attenuated rotavirus vaccines." .
January 2008 Jung K, Alekseev K, Tang Y, Lewis P, Zhang X, Saif LJ."Impact of prior infection with porcine reproductive and respiratory syndrome virus (PRRSV) on the severity of porcine respiratory coronavirus (PRCV) pneumonia as a model for SARS respiratory co-infections" .
January 2008 Alekseev K, Vlasova A, Jung K, Hasoksuz M, Zhang X, Halpin R, Wang S, Ghedin E, Spiro D, Saif LJ."Bovine-like coronaviruses isolated from captive wild ruminants are homologous to bovine coronaviruses based on complete RNA genomic sequences" .
January 2008 Yuan L, Rao S, Li G, Azevedo MSP, Azevedo AC, Saif LJ."Genome sequence analysis of human rotavirus M (G3P1A[8]) strains" .
January 2008 LI G, Rao S, Azevedo MSP, Saif LJ, Azevedo AC, Zhang W, Hoshino Y, Yuan L."Comparison of genome sequences of virulent, cell-culture adapted and attenuated WA strain human rotaviruses" .
January 2008 Saif LJ."Interspecies Transmission of Coronaviruses: Lessons for SARS. SARS, Animal Coronaviruses, Interspecies Transmission." .
January 2008 Ha HTP, Saif LJ, Park SI, Jeong YJ, Hosmillo M, Shin DJ, Chun YH, Hyun BH, Kang MI, Cho KO."Sequence analysis of unusual P[7]G5 bovine rotavirus strains reveals evidence for interspecies transmission" .
January 2008 Azevedo MSP, Vlasova A, Resque H, Tang Y, Morein B, Lovgren-Bentsson K, Saif LJ."Effects of polyIC or rIFN-α on the Th1/Th2/Th3 cytokine responses of gnotobiotic pigs inoculated with a rotavirus-like particles (VLP) vaccine" .
January 2008 Azevedo MSP, Jung K, Alekseev K, Vlasova A, Hasoksuz M, Han MG, Zhang X, Saif LJ."Homologous bovine enteric coronavirus induces a distinct serum cytokine profile from heterologous coronaviruses in infected gnotobiotic calves" .
January 2008 Yuan L, Zhang W, Wen K, Liu F, Azevedo MSP, Saif LJ, Gonzalez AM, Li G, Yousef AE."Mechanism of lactobacilli’s adjuvant effect on enhancing the immunogenicity and protective efficacy of a live attenuated rotavirus vaccine" .
January 2008 Park SI, Park S, Saif LJ, Hyun BH, Jeong YJ, Ha MTP, Hosmilo M, Kang MI, Cho KO."Molecular characterization of G8 and G6 bovine rotaviruses reveals multispecies reassortments in most of the genes" .
January 2008 Jung K, Alekseev K, Renukaradhya GJ, Tang Y, Fang Y, Lewis P, Saif LJ."Altered pathogenesis of porcine respiratory coronavirus (PRCV) subsequent to PRRSV infection: Model for effect of respiratory viral co-infections on SARS severity" .
January 2008 Jee J, Azevedo M, Vlasova A, Hoet A, Loerch SC, Pickworth C, Hanson J, Saif LJ."Effect of vitamin A on bovine coronavirus infection, vaccination and immunity in feedlot calves" .
January 2009 Saif, L.J., K. Jung, G.J. Renukaradhya, and X. Zhang."Respiratory viral co-infections and corticosteroid treatments influence disease, pathology and immunologic responses to a porcine respiratory coronavirus of pigs" .
January 2009 Yuan, L., K. Wen, W. Zhang, M.S.P. Azevedo, A.M. Gonzalez, L.J. Saif, and A. Yousef."TCR-gamma/delta T cell responses to lactobacilli intestinal colonization, rotavirus infection and vaccination in neonatal gnotobiotic pigs." .
January 2009 Saif, L.J.."Gut reactions to rotavirus vaccines in a gnotobiotic piglet disease model: a priming lesson for neonatal mucosal immunity" .
January 2009 Vega, C., P. Chacana, L. Garaicoechea, D. Rodriguez, H. Terzolo, L.J. Saif, F. Fernandez, and V. Parreno."Egg yolk immunoglobulins: supplement for the preention of RV diarrhea and effect in the development of the immune response in newborn calves" .
January 2009 Wang, Q., Z. Zhang, and L.J. Saif."Impact of pH on attachment of the enteropathogenic calicivirus porcine sapovirus to lettuce leaves" .
January 2009 Vlasova, A.N., M.S.P. Azevedo, H.R. Resque, A.M. Hartzler, and L.J. Saif."The effect of virulent human rotavirus challenge on TLR3 and 4 responses and plasmacytoid dendritic cell distribution in gnotobiotic pigs vaccinated with rotavirus-like particles (VLPs)" .
January 2009 Renukaradhya, G.J., K. Alekseev, K. Jung and L.J. Saif."Distorted immune responses in pigs to porcine respiratory coronavirus previously infected with porcine reproductive and respiratory syndrome virus: a respiratory viral co-infection model" .
January 2009 Resque, H.R., A.N. Vlasova, M.S.P. Azevedo, A.M. Hartzler, and L.J. Saif."Rotavirus-like particle (CLP) vaccines with/without attenuated rotavirus priming induce heterotypic rotavirus antibody responses but low protection rates to heterotypic rotavirus challenge" .
October 2010 Takanashi, S., Q.H. Wang, K. Jung, Z. Zhang, N. Chen, Q. Shen, Q., and L.J. Saif."Prolonged virus shedding in an immunocompetent child in a GII.12 human norovirus outbreak" . : Abst.
July 2010 Vlasova, A.N., R. Halphi, S. Wang, E. Ghedin, D. Spiro and L.J. Saif."Molecular characterization of a coronavirus associated with mink epizootic catarrhal gastroenteritis" . : Abst. #W16-10
February 2010 Saif, L.J.."Efficacy and potency testing of vaccines for enteric pathogens: correlates and concerns for mucosal vaccines" .
December 2010 Chattha, K.S., A. Vlasova, C. Siegismund, N. Chen, and L.J. Saif."Preliminary investigation of B cell immune responses to rotavirus in vitamin A deficient piglets." . : Abst.
July 2010 Mullis, LB., L.J. Saif, and M.P. Azevedo."Stability of bovine coronavirus on lettuce surfaces under household refrigeration conditions" . : Abst. #W16-10
October 2010 Jung, K., Q. Wang, Z. Zhang, S. Takanashi, K. Scheuer, Q. Shen, Y. Kim, K.O. Chang, and L.J. Saif.."Simvastatin enhances GII.4 human norovirus infectivity in gnotobiotic pigs." . : Abst.
October 2010 Wang, Q., K. Scheuer, Z. Zhang, W. Gebreyes and L.J. Saif."Characterization and prevalence of new porcine caliciviruses in US swine." . : Abst.
January 2010 Louge Uriarte, E., G. V. Parreño, E. Späth, M. R. Leunda, L. J. Saif, A.C. Odeón."Circulacion de rotavirus and coronavirus bovine and terneros de tambo y cria con y sin diarrhea (2007-2009)." . : Abst.
June 2011 Vlasova, A., R. Halpin, S. Wang, E. Ghedin, D. Spiro, D., and L.J. Saif."Molecular characterization of a new alphacoronavirus species associated with mink epizootic catarrhal gastroenteritis" . : Abst.
July 2011 Martella, V., E. Lorusso, Q. Wang, P. Pinto, P. Moschidou, A.L. Bellacicco, V. Larocca, N. Decaro, L.J. Saif, and C. Buonavoglia."Canine Vesiviruses" . : Poster P18-1
July 2011 Chattha, K.S., A.N. Vlasova, C.S. Siegismund, and L.J. Saif."Vitamin A deficiency affects serum antibody responses to rotavirus vaccination and challenge in a gnotobiotic piglet model" . : Abst.
April 2011 Takanashi, S., N. Chen, Q.H. Wang, K. Jung, Z. Zhang, and L.J. Saif."Prolonged virus shedding in an immunocompetent child in a GII.g/GII.12 human norovirus outbreak" . : Abst
May 2011 Lee, C.S., C. Lee, Q. Wang, L.J. Saif and J. Lee."Monitoring of human adenovirus, enterovirus and norovirus in Ohio inland beaches" . : Abst.
July 2011 Wang, Q., Z. Zhang, and L. J. Saif."Validation of tissue culture-adapted porcine sapovirus as an improved surrogate for human norovirus to assess viral stability and decontamination methods" . : Poster P18-19
July 2011 Silva, C., L. Mullis, R. Owens, L.J. Saif, D. Taylor, L. Haynes, X. Zhang and M.S.P. Azevedo."Human respiratory coronaviruses circulating during the influenza season in Arkansas" . : Abst.
July 2011 Scheuer, K. A., Q. Wang, A. E. Hort, W. A. Gebreyes, B. Z. Molla, and L. J. Saif."Prevalence of noroviruses in US finisher swine" . : Abst. W26-9
July 2011 Mullis, L., J. Britt, C. Silva, X. Zhang, and L.J. Saif, R. Steele and M.S.P. Azevedo."Prevalence of recently circulating coronaviruses in domestic animals and wildlife in Arkansas USA" . : Abst.
July 2011 Pinto, P., Q. Wang, N. Chen, and L. J. Saif."A novel feline calicivirus clusters in genogroup IV noroviruses" . : Abst. W26-8
July 2011 Takanashi, S., K. Chattha, M. Khatri, K. Jung, A. Vlasova, K. Scheuer, L.J. Saif, and W. Wang."Attempts to propagate human noroviruses in porcine small intestinal enterocytes and hematopoietic lineage cells" . : Poster P18-3
July 2011 Esseili, M. A., Q. Wang, Z. Zhang, and L. J. Saif."Persistence and mode of transmission of sapovirus, a surrogate for norovirus, in leafy greens." . : Poster P37-2
September 2011 Saif, L.J..". Enteric food and waterborne pathogens. Plenary: Noroviruses and food safety: Epidemiology, surrogates and animal model" .
December 2011 Saif, L.J., A. Vlasova, K. Chattha and S. Kandasamy."Gut reactions to rotavirus vaccines in neonates: Overcoming obstacles to improve efficacy" .
July 2012 Parreno, V., D. Rodriguez, A. Badaracco, I. Nunez, E.L. Uriarte, R. Galarza, G. Bilbao, P. Brandao, L.J. Saif, and F. Fernandez."Bovine coronavirus detected in diarrheic calves in beef and dairy herds from Argentina from 1994 to 2010" . : Abst.
July 2012 Oka, T., E. Tokuoka, K. Naoko, K. Nishimura, Y. Shimada, T. Ueno, S. Ikezawa, T. Wakita, K. Katayama, L.J. Saif. And S. Harada."Nine year sapovirus surveillance reveals clear geneotype shift and presence of re-infection gastroenteritis cases with different genogroups" . : Abst.
July 2012 Chen, N., Q. Wang, Z. Zhang, P. Pinto, M. Yokoyama, and L.J. Saif."Molecular mechanism of cell culture adaptation of porcine sapovirus" . : Abst.
July 2012 Amimo, J., A. Vlasova and L.J. Saif."Prevalence and diversity of group A and non-group A porcine rotaviruses in selected US farms" . : Abst.
July 2012 Kandasamy, S., K.S. Chattha, A. Vlasova, G. Rajashekara and L.J. Saif."Probiotics augment B cell responses to oral rotavirus vaccine in neonatal gnotobiotic pigs" . : Abst.
March 2012 Takanashi S., L.J. Saif, J.H. Hughes, T. Meulia, K. Jung, K. Scheuer, and Q. Wang."Attempts to propagate human noroviruses in three-dimensional cell cultures." .
July 2012 Jung, K., K. Scheuer, Z. Zhang, Q. Wang and L.J. Saif."Pathogenesis of bovine norovirus GIII.2 strain CV186-OH/00/US in gnotobiotic calves" . : Abst.
May 2012 Chattha, K.S., Vlasova, A., Esseili, M., Siegismund, C., Kandasamy, S., Rajashekara, G., Saif, L.J.."Probiotics and lactogenic immune factors affect neonatal B cell responses to rotavirus vaccine" .
July 2012 Oka, T., H. Takagi, M. Miki, K. Murakami, Y. Tohya, T. Wakita, L.J. Saif and K. Katayama."Development of plasmid DNA transfection-based reverse genetics system for feline calicivirus" . : Abst.
December 2012 Chattha, K.S., A.N. Vlasova, S. Kandasamy and L.J. Saif."Probiotics modulate T cell and cytokine responses to oral rotavirus vaccine and challenge in a neonatal gnotobiotic piglet model" .
July 2012 Esseili MA, Wang, Q., Z. Zhang and L.J. Saif."Enhanced persistence of a food-borne enteric calicivirus in/on physically damaged lettuce" . : Abst.
December 2012 Vlasova, A.N., K.S. Chattha, S. Kandasamy, C.S. Siegismund and L.J. Saif."Vitamin A deficiency alters innate immune responses to human rotavirus in gnotobiotic pigs" .
July 2013 Chattha, K.S., S. Kandasamy, A.N. Vlasova, and L.J. Saif."16th Intl. Congress on Mucosal Immunology" .
March 2013 Saif, LJ."Infant Immunity Grantees Workshop and Meeting" .
August 2013 Saif, L.J., A.N. Vlasova, K.S. Chattha, and S. Kandasamy."Prenatally acquired Vitamin A deficiency alters innate and antibody immune responses and reduces rotavirus vaccine efficacy in a gnotobiotic piglet model" .
December 2013 Wang, Q., T. Oka, M. Esseili, S. Sommer-Wagner, T. Meulia, Y. Zhang, and L.J. Saif."Isolation and characterization of porcine epidemic diarrhea virus (PEDV) for development of serologic tests and vaccine" .
August 2013 Saif, L.J., A. Vlasova, K. Chattha and S. Kandasamy."2nd International Congress on Pathogens at the Human-Animal Interface (ICOPHAI): One Health for Sustainable Development" .
October 2013 Oka, T., G.T. Stoltzfus, C. Zhu, K. Jung, Q Wang, and L.J. Saif."Attempts to grow human and animal noroviruses in vitro" . : P-4
May 2013 Kumar, A., A. N. Vlasova, Z. Liu, K.S. Chattha, S. Kandasamy, M. Esseili , X. Zhang, L.J. Saif and G. Rajashekara.". Public Health Preparedness for Infectious Diseases (PHPID) mtg" .
July 2013 Wang, Q., Z. Sisay, T. Oka and L.J. Saif."Prevalence and molecular characterization of porcine enteric caliciviruses and first detection of porcine kobuviruses in US Swine" . : P25-17
July 2013 Vlasova, A.N., K.S. Chattha, S. Kandasamy, Z. Liu, M. Esseili, G. Rajashekara, L.J. Saif."Lactobacilli and Bifidobacteria promote immune homeostasis and modulate innate immune responses to human rotavirus vaccine and challenge in neonatal gnotobiotic pigs" . : 76
May 2013 Saif, L.J., K.S. Chattha, S. Kandasamy, C.S. Siegismund, and A.N. Vlasova."Immunology 2013, AAI Annual Meeting" . : P6145
December 2013 Saif, LJ."CRWAD" .
October 2013 Wang, Q., K.A. Scheuer, T. Oka, A.E. Hoet, W.A. Gebreyes, B.Z. Molla, and L.J. Saif."Molecular characterization of emerging porcine sapoviruses from finisher swine in the United States, and unified classification scheme for sapoviruses" . : 2-5
October 2013 Lu, Z., K. Jung, T. Oka, Q. Wang, and L.J. Saif.."Comparative pathogenesis of tissue culture porcine sapovirus Cowden strain and infectious clone mutants in gnotobiotic pigs" . : P-5
July 2013 Kandasamy, S., K.S. Chattha, A.N. Vlasova, G. Rajashekara, and L.J. Saif."16th Intl. Congress on Mucosal Immunology" .
May 2014 Kandasamy, S. Vlasova, A.N., Chattha, K.S., Fisher, D., Shao, L., Rajashekara, G., Saif, L.J.."Immunology 2014" .
December 2014 Annamalai, T, C-M. Lin, X. Liu, Z. Lu, H. Hu, X. Gao, L.J. Saif and Q. Wang."CRWAD" .
May 2014 Saif, L.J., A. Vlasova, S. Kandasamy, L. Shao, A. Rauf, D.D. Fischer, K.S. Chattha, A. Kumar, and G. Rajashekara."Proc. Immunology 2014" .
June 2014 Jung, K., Q. Wang, K.A. Scheuer, Z. Lu, Y. Zhang, and L.J. Saif."Proc. ASV" .
December 2014 Saif, L.J., A.N. Vlasova, S. Kandasamy, and K. Chattha."CRWAD" .
June 2014 Oka, T. L.J. Saif, Z. Yang, K.A. Scheuer, G.T. Stoltzfus and Q. Wang."Proc of American Society of Virology" .
June 2014 Esseili, M.A., L.J. Saif, T. Farkas and Q. Wang."Proc. ASV" .
June 2014 Oka, T., N. Ogo, M. Oba, T. Ando, C. Zhu, A. Asai, K. Katayama, Q. Wang and L.J. Saif."Proc. ASV" .
December 2014 Lin, C.M. X. Gao, T. Oka, A.N. Vlasova, Q. Wang, and L.J. Saif."CRWAD" .
December 2014 Jung, K, B. Eyerly, H. Hu, Z. Lu and L.J. Saif."CRWAD" .
December 2014 Shao, L., L.J. Saif, D. Fischer, S. Kandasamy, A. Rauf and A. Vlasova."CRWAD" .
December 2015 Vlasova, A.N., S. Kandasamy, L. Shao, D. Fischer, A. Rauf, S.N. Langel, K. Chattha, A. Kumar, H.C. Huang, M. Abdulhameed, G. Rajashekara and L.J. Saif."CRWAD" .

Presentations

Zoonotic Aspects of Rotavirus and Calicivirus Infections, New and Re-emerging Infectious Diseases. Third Annual Conference at the College of Veterinary Medicine, University of Illinois, April 20-21, 2000.

Mucosal Immunity to Rotavirus Vaccines College of Veterinary Medicine at the University of Maryland, April 5, 2000.

Mucosal Immunity to Human Rotavirus Vaccines in a Gnotobiotic Pig Model. Novartis Foundation and the Wellcome Trust, London, England, May 19, 2000.

Invited Oral Presentation and PhD opponent for Thesis of Madeline Traven, Sweden

Comparative Antibody-secreting Cell (ASC) Responses and Protection Induced by Wa 2/6 Rotavirus-like Particles (VLPs) with Mutant LT (mLT) Adjuvant and With/without Oral Attenuted Wa Human Rotavirus (HRV) in a Gnotobiotic Pig Disease Model. 7th Int. Sympo

Zoonotic Aspects of Rotavirus Infections and Adaptation to New Hosts. Symposium on Rotaviruses of Animals and Humans at the National Academy of Veterinary and Agricultural Sciences, Buenos Aires, Argentina, March 20, 2001.

Viral Enteritis of Nursery Pigs. Workshop. Amer. Assoc. Swine Veterinarians, Nashville, TN, February 24-27, 2001.

Relationships Between Human and Animal Enteric Caliciviruses and the Ohio Link to Foodborne Viruses. Food Safety Seminar Series, Food Science and Technology, The Ohio State University, Columbus, OH, November 20, 2001.

Porcine and Bovine Enteric Caliciviruses: Relationships to Human Enteric Caliciviruses. Veterinary Virology Symposium: Emerging and Zoonotic Animal Viral Diseases, Satellite Mtg. of Amer. Soc. of Virol., Madison, WI, July 21, 2001.

Evaluation of Vaccines to Induce Intestinal Antibody Secreting Cells (ASC) and Memory B-cells to Rotavirus and Protection in a Gnotobiotic Pig Model of Human Rotavirus Diarrhea. Brazil Soc. Virol., Caldas Novas, Goias, Brazil, Nov. 25-28, 2001.

Development and Application of Rotavirus-like Particle (VLP) Maternal Vaccines to Provide Passive Immunity to Calves. College of Veterinary Medicine, Chungbuk National University, Cheongju, Korea, October 15, 2001.

Development and Application of Rotavirus-like Particle (VLP) Maternal Vaccines to Provide Passive Immunity to Calves. 45th Annual Meeting of the Korean Society of Veterinary Science, Korea, October 12, 2001.

Coronaviruses: Update on Diagnosis, Pathogenesis and Control of Bovine Coronavirus-associated Calf Diarrhea Winter Dysentery and Shipping Fever. Iowa Veterinary Medical Association and Iowa State University, College of Veterinary Medicine, Ames, IA, Septe

Enteric caliciviruses of humans and animals. Midwest Veterinary Conference, Columbus, OH, February 23, 2003

Coronavirus biology and SARS. World Health Organization, Geneva, Switzerland, October 20-21

Animal Coronaviruses: Lessons for SARS. SARS workshop sponsored by the Institute of Medicine of the National Academies of Science in Washington, DC on September 30-October 1

Veterinary research needs: Where are we? Where are we going? Workshop, Integrating Veterinary Science and Research, National Academy of Sciences, Washington, DC, July 18-20, 2004

Keynote speaker:Animal coronaviruses: Lessons for SARS; SARS: Lessons for Veterinarians. Phi Zeta Research Day., Kansas State University, Manhattan, KS, March 1-3, 2004

Invited speaker: Prevalence and molecular characterization of porcine noroviruses and sapoviruses and comparisons with human enteric caliciviruses. 2nd International Calicivirus Conference, Dijon, France, November 5-10, 2004

Invited speaker: Antigenic relationship between human SARS coronavirus and animal coronaviruses. American Society of Virology, Montreal, Canada, July 9-14, 2004

Invited speaker: Animal coronaviruses: Lessons for SARS; SARS: Lessons for Veterinarians. Midwest Veterinary Conference, Columbus, Ohio, February 26-29, 2004

DNA vaccines for rotaviruses evaluated in a gnotobiotic pig model of human rotavirus disease. Vaccines for Enteric Diseases, Montego Bay, Jamaica, April 27-30, 2004

Comparative biology of animal coronaviruses and SARS. International Symposium on Avian Corona- and pneumoviruses. Rauischholzhausen, Germany, June 20-23, 2004

Comparative aspects of vaccines for animal coronaviruses and human SARS coronavirus. International Conference on AIDS and other Infectious Diseases, Nanning, China, December 1-3, 2004

Comparative aspects of animal coronavirus infections and SARS. Chinese Society of Virology, Nanning, China, November 30-December 1, 2004

Avian and mammalian coronaviruses: Lessons for SARS and mucosal vaccines. 5th International Symposium on Turkey Diseases, Berlin, Germany, June 15-19, 2004

Animal coronaviruses: Lessons for SARS and mucosal vaccines. 7th Annual Conference on Vaccine Research, National Foundation for Infectious Diseases, Arlington, VA, May 24-26, 2004

Animal coronavirus vaccines: Lessons for SARS and mucosal vaccines. OIE/IAB International Conference on “The Control of Infectious Animal Diseases by Vaccination�, Buenos Aires, Argentina, April 12-15, 2004

Keynote speaker: “Vaccines to induce mucosal immunity to rotavirus evaluated in a neonatal gnotobiotic pig disease model�. Third Intl. Rushmore Conference on Enteric Diseases, Rapid City, SD, September 29-October 1, 2005

Keynote speaker: “Rotavirus: Pathogenesis, Attenuation and Vaccine Safety�. WHO Consultation on Quality, Safety and Efficacy Specification for Live Attenuated Rotavirus Vaccines. Mexico City, Mexico, February 8-9, 2005

Keynote speaker: “Comparative Biology of Animal Coronaviruses and SARS�. Intl. Symposium on Advanced Virology, Beijing, China, October 10-13, 2005

Keynote speaker: “Animal Coronaviruses: Pathogenesis, Immunity, Vaccines and Lessons for PRRSV�. PRRSV Intl. Symposium, St. Louis, MO. December 3, 2005

Keynote speaker: “Animal Coronavirus Vaccines: Lessons for SARS�, 10th Intl. Nidovirales Symposium, Colorado Springs, CO, June 26-30, 2005

“Porcine Models for Human Viral Diseases: Pathogenesis and Immunity Swine�. In Biomedical Research Conference, Chicago, IL, January 27-29, 2005

“Mucosal Immunity and Rotavirus Vaccines�. Chinese CDC, Beijing, China, October 13, 2005

“Comparative Pathogenesis of Animal and SARS Coronaviruses: Mechanisms of Disease Modulation�. Seminar series, University of Denver Health Sciences Center, Denver, CO, May 13, 2005

“Comparative Aspects of Animal Coronaviruses and SARS�. Seminar series, National Animal Disease Center, Ames, IA, March 30, 2005

“Blood, Guts and Germs: Concepts and Applications of Mucosal Immunity to Enteric Viral Vaccines�. Mucosal Immunology Conference, College of Veterinary Medicine, The Ohio State University, Columbus, OH, September 18-19, 2005

“Biologic Aspects of Interspecies Transmission of Coronavirus and Other Enteric RNA Viruses�. Emergence of New Epidemic Viruses Through Host Switching Workshop, Sponsored by NIAID, NIH, Washington, DC, September 6-8, 2005

“Animal Coronaviruses: Pathogenesis, Immunity, Vaccines and Lessons for SARS�. New Horizon in Vaccine and Cell Therapy Symposium, Chonnam National University Vaccine Institute, Gwangju, Korea, November 2-5, 2005

“Animal Coronaviruses: Lessons for SARS�. OSU-Extension-Veterinary Medicine, Animal Health and Disease Update In-Service, The Ohio State University, Columbus, OH, October 24, 2005

“Animal and SARS Coronaviruses: Mechanisms of Disease Modulation� University of Ankova, Biotechnology Institutes, Ankara, Turkey, August 24, 2005

Speaker. “Cytokine Responses to Vaccination with a Non-replicating Rotavirus VLP-ISCOM Vaccine Compared to Infection With Human Rotavirus In Gnotobiotic Pigs�, 9th International Symposium on dsRNA Viruses, Cape Town, South Africa, October 21-26, 2006.

Invited speaker, NCID Distinguished Lecturer Series, “Concepts and Applications of Mucosal Immunity to Rotavirus Vaccines�, Centers for Disease Control and Prevention, Atlanta, GA, April 18-20, 2006.

Invited speaker, “Overview of Mucosal Immunity to Infectious Agents and Vaccines�, AIDS Vaccine Research Working Group Meeting, NIAID, NIH, Bethesda, MD, May 25, 2006.

Invited seminar speaker, “Immunity and Vaccines for Animal Coronaviruses: Implications for SARS�, Drexel University Seminar Series, Philadelphia, PA, April 4-5, 2006.

Invited keynote speaker: Fellows Workshop, “Concepts and Applications of Mucosal Immunity to Enteric Viral Vaccines: Lessons and Gaps for HIV Vaccines�, HIV Pathogenesis and HIV Vaccines, Keystone Symposium, Keystone, Colorado, March 26-April 2, 2006.

Invited keynote speaker, “Molecular Detection of Swine Enteric Caliciviruses (Noros and Sapos) and Their Zoonotic Potential Based on Genetic and Antigenic Comparisons with Human Caliciviruses�, 4th International Veterinary Vaccines and Diagnostics Confere

Speaker “Mucosal Immunity and Vaccines to Enteric Viral Pathogens: Lessons for HIV� Mucosal Immunity and HIV/AIDS Vaccines Conference, Division of AIDS (DAIDS), National Institute of Allergy and Infectious Diseases (NIAID),Fondation Mérieux Conference Ce

Invited speaker “Rotavirus Vaccines evaluated in a Neonatal Disease Model: Lessons and Challenges�. The 4th Intl. Conf. on Vaccines for Enteric Diseases, Lisbon, Portugal, April 25-27, 2007.

Invited speaker “Identification of the antigenic region of the nucleoprotein (N) that mediates cross-reactivity between Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) and animal group 1 CoVs “ International SARS Coronavirus Workshop, National In

Respiratory viral co-infections and corticosteroid treatments influence disease, pathology and immunologic responses to a porcine respiratory coronavirus of pigs

Pathogenesis of Enteric Viruses

Pathogenesis and Mucosal Immunity to Enteric Viruses

North and south united to conquer viral diarrheas using innovative passive immunity strategies

Mucosal immunity to enteric viruses: gut reactions to rotavirus vaccines

Journeys in academia, globally and through the viral nanocosmos

Gut reactions to rotavirus vaccines: Lessons for mucosal immunity

Gut reactions to rotavirus vaccines in a gnotobiotic piglet disease model: a priming lesson for neonatal mucosal immunity

Gut reactions to classical and novel rotavirus vaccines in a neonatal animal disease model

Cruising for noroviruses: Pig tales and pig types

Oh, the places you’ll go!

Cruising for noroviruses: Epidemiology and pig tales� and “Pathogenesis of human noroviruses in gnotobiotic pigs

Respiratory viral co-infections and corticosteroids alter immune responses and enhance immunity in a porcine respiratory coronavirus model in pigs: lessons for SARS

Enhancement of rotavirus vaccines in a neonatal gnotobiotic piglet disease model for infants in developing countries

Immunology of rotavirus candidate vaccines

Emerging and Zoonotic Viruses

Cruising for Noroviruses: Pig types and pig tales

Noroviruses in swine: Epidemiology, relatedness to human noroviruses and in a pig model of human norovirus infection

Gut integrity in the developing world

Efficacy testing of vaccines for enteric infections: Correlates and concerns for mucosal vaccines

Presented norovirus research update as co-PI for U01 NIAID, NIH (K.O. Chang, PI) “Development of novel therapeutic agents for norovirus infection

Pathogens in rural and agricultural water and watersheds

Gut reactions to rotavirus vaccines: a priming lesson for neonatal mucosal immunity

Germfree piglet model for human enteric viral disease and gut immunity

Enteric food and waterborne pathogens. Noroviruses and food safety: Epidemiology, surrogates and animal model

The ABCs of swine rotavirus infections

Gut reactions to rotavirus vaccines in neonates: Overcoming obstacles to improve efficacy

Pig model for human norovirus to evaluate antivirals

Host genetics and immune response to enteric pathogens

Emerging Zoonotic Diseases symposium

SARS/MERS Coronavirus Symposium

Lactobacillus rhamnosus GG and Bifidobacterium animalis subsp. lactis Bb12 probiotics modulate rotavirus diarrhea and immune responses to a human rotavirus vaccine in a neonatal gnotobiotic piglet model

Coronavirus Natural History

Animal Coronaviruses: Lessons for SARS and MERS

Lactobacilli and Bifidobacteria promote immune homeostasis and modulate innate immune responses to human rotavirus vaccine and challenge in neonatal gnotobiotic pigs

Animal Coronaviruses: Interspecies transmission and lessons for SARS and MERS Coronaviruses

Impact of vitamin A deficiency and probiotics on vaccination and infection with rotavirus in the germ-free pig model

Prenatally acquired vitamin A deficiency alters innate immune responses to human rotavirus in a gnotobiotic pig model

Gut reactions to rotavirus vaccines: Strategies to improve

Prenatally acquired Vitamin A deficiency alters innate and antibody immune responses and reduces rotavirus vaccine efficacy in a gnotobiotic piglet model

The ABCs of swine rotavirus infections

Animal Coronaviruses: Interspecies transmission and lessons for human Coronaviruses

, Intestinal ecological niches of enteric viruses influence their pathogenesis and diarrhea severity

Gut reactions to human rotavirus vaccines: Strategies to improve efficacy in developing countries

Targeting MERS coronavirus vaccines in camels: Bovine coronavirus vaccine strategies

Escherichia coli Nissle 1917 colonization upregulates innate immunity and partially protects against human rotavirus infection in a neonatal gnotobiotic pig model

Animal coronaviruses: Lessons for SARS and MERS human coronaviruses

Complete genome analysis of US PEDV strains reveals two American clades and a new cluster containing insertions and deletions in the spike gene

Bovine coronaviruses: Lessons for MERS coronavirus in camels

Animal coronaviruses: Lessons for SARS-like and MERS coronaviruses

Escherichia coli nissle 1917 colonization upregulates innate immunity in a gnotobiotic piglet model

Tailoring probiotics as immunomodulators to enhance neonatal mucosal immunity to rotavirus (RV) vaccines or alleviate RV diarrhea: Evaluation in a neonatal gnotobiotic piglet model

Lactogenic immunity and vaccines for PEDV: Lessons from TGEV trials and tribulations

Gut microflora impact on neonatal immunity, viral gastroenteritis and vaccines

Global Emerging Coronaviruses: MERS, SARS and PEDV

Differential effects of Escherichia coli Nissle and Lactobacillus rhamnosus strain GG on human rotavirus infection and B cell responses

Gut reactions to human rotavirus: Probiotics immunomodulate diarrhea and vaccine efficacy in a germfree neonatal piglet model

Why we should eat our carrots: Vitamin A deficiency impacts neonatal rotavirus vaccines, immunity and disease

Global Emerging Coronaviruses: MERS, SARS and PEDV

Bovine Coronaviruses: Vaccines and Lessons for MERS in Camels

Wolf Award Science Denial/Vaccine Panel Presentation

Wolf Award Presentation

Differential effects of Escherichia coli Nissle and Lactobacillus rhamnosus strain GG on human rotavirus infection and B cell responses

Elusive Coronavirus Vaccines: Strategies for PEDV Vaccines and Lessons from TGEV Vaccines

Effects of antibiotics, probiotics and malnutrition on modulation of human rotavirus disease, host immunity and metabolism in neonatal gnotobiotic pigs colonized with commensal microflora.

Passive immunity and vaccines for porcine epidemic diarrhea virus (PEDV): lessons from TGEV vaccines

Immunology Symposium: Gut reactions to rotavirus vaccines: Strategies to improve efficacy in developing countries

Animal coronaviruses: Historical perspectives for emerging human coronaviruses

Coronavirus Update: Global threats to humans and animals

My career as a female scientist.

Human rotavirus vaccines evaluated in germfree pigs

Rotavirus Vaccines for Induction of Mucosal Immunity. Symposium on Rotaviruses of Animals and Humans at the National Academy of Veterinary and Agricultural Sciences, Buenos Aires, Argentina, March 20, 2001.

Enteric Viral Vaccines: Strategies to Induce Intestinal Immunity and Protection Using Rotavirus Infection of Pigs As a Model. 2nd Int. Veterinary Vaccines and Diagnostics Conference, Oxford, England, July 23-28, 2000.

Enteric Caliciviruses in Pigs and Calves and Their Relationship to Human Caliciviruses. Brazil Soc. Virol., Caldas Novas, Goias, Brazil, Nov. 25-28, 2001.

Correlates of Protection and Mucosal Immunity to Human Rotavirus in a Gnotobiotic Pig Model of Disease. Swedish Agricultural University, Faculty of Veterinary Medicine, National Veterinary Institute, Uppsala, Sweden, May 25, 2000

Animal Rotaviruses and Enteric Caliciviruses: Zoonotic Potential and Adaptation to New Hosts. 51st North Central Avian Disease Conference and Symposium on Emerging and Re-emerging Disease, Columbus, Ohio, October 8-10, 2000.

Vaccination Strategies to Induce Protective Immunity to Human Rotavirus in a Neonatal Gnotobiotic Pig Disease Model. Vaccines for Enteric Diseases, Tampere, Finland, September 12-14, 2001.

Vaccination Strategies to Enhance Antibody Titers to Rotavirus in Colostrum of Cows and Provide Passive Immunity to Calves. 2nd Int. Veterinary Vaccines and Diagnostics Conference, Oxford, England, July 23-28, 2000.

SARS and Animal Coronavirus. NY Academy of Science, New York, NY, May 17

 

Professional Activities

present Annual Reviews, Animal & Veterinary Biosciences Editorial Board.
present Conference on non-replicating rotavirus vaccine candidates PATH. Bill and Melinda Gates Foundation.
present USDA NIFA Food Virology Collaborative (NoroCORE) meeting.
present NAS Annual Meeting (Section 61 Chair). NAS.
present NAS, Class Membership Committee Meeting, Western Regional NAS meeting.
present Annual Reviews Animal Biosciences Editorial Board.
present Linda Saif. International Conference on Caliciviruses.
present International Veterinary Immunology Symposium.
present National Academy of Sciences and PNAS Editorial Board Annual Meetings. NAS.
present Infectious Diseases of Concern to Captive and Free Ranging Animals in North America, 2nd ed. 2013. Infectious Disease Committee, American Association of Zoo Veterinarians, Gamble, K.C.& M.M. Clancy (eds)..
present American Association of Immunologists. AAI.
present CRWAD. Chicago, IL.
present Plant and Animal Genome XX Meeting.
2004 - present National Academy of Sciences and PNAS Editorial Board Annual Meeting. NAS. Washington, DC.
2009 - present NC1041 Enteric Diseases of Swine and Cattle: Prevention, Control and Food Safety. NC1041. Chicago, IL.
2011 - present Annual Reviews Animal Biosciences (ARAB) Editorial Board. Monterey Bay, CA.
2010 Symposium "Practical Alternatives to Reduce Animal Testing in Quality Control of Veterinary Biologicals in the Americas".
2010 CMIB Annual Meeting DHLRI. OSU Medical Center. Columbus, OH.
2010 National Synthesis Workshop: Pathogens (Bacteria, Viruses and Protozoa) in Rural and Agricultural Water and Watersheds, Cornell University. USDA/CSREES. Ithaca, NY.
2010 National Foundation for Infectious Diseases,. 13th Annual Conference on Vaccine Research. Bethesda, MD.
2010 Oral vaccination response in developing countries and the intestinal microbiome. NIH Conference.
2010 Second Global Conference of OIE, Head of OIE Reference Lab. OIE.
2010 4th Intl. Calicivirus Symposium.
2010 American Association of Immunologists 97th Annual Meeting. AAVI. Baltimore, MD.
2010 American Society of Virology Meeting and Satellite Meetings. ASV. Bozeman, MT.
2010 2010 International Symposium on Important Zoonoses.
2010 Gut integrity in the developing world. Bill and Melinda Gates Foundation. Seattle, WA.
2011 Intl Congress Mucosal Immunology meeting (ICMI).
2009 - 2012 Class Membership Committee Mtg, Western Regional NAS meeting, Class 61, Chair. National Academies of Science.
2009 - 2012 NAS Annual Meeting.
 

Technical Reports

Norovirus nucleotide sequence, human norovirus HS194 strain. Genbank accession #GU325839

Calicivirus nucleotide sequence, porcine calicivirus WGP93C strain. Genbank accession # GU592498

Molecular characterization of a new alphacoronavirus species associated with mink epizootic catarrhal gastroenteritis. Genbank MCoV WD1127, acc# HM245925, and MCoV WD1133, acc# HM245926