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Lauren Bakaletz, PhD


Staff photo

700 Childrens Dr
Columbus, OH 43205

Phone: (614) 722-2915

Email: bakaletz.1@osu.edu

 

Current OSU Appointments

Professor, Pediatrics

Professor, Otolaryngology

Professor, SBS-Microbial Infectn/Immunity

 

Biographical

Research Interests: Molecular mechanisms of pathogenesis that underlie the polymicrobial disease otitis media (OM), with a particular interest in bacterial adhesins and other determinants that contribute to biofilm formation. Design, development and pre-clinical testing of vaccine candidates for the prevention of Otitis Media

Chapters in Books

Bakaletz LO. "Otitis Media." In Polymicrobial Diseases. Edited by Brogden, K.A. and Guthmiller, J.M.. -. Washington, D.C.: American Society for Microbiology Press, January 2002.

Bakaletz LO. "Peptide Vaccine for Otitis Media." In Handbook of Biologically Active Peptides. Edited by Kastin, A.J.. -. San Diego: Elsevier, January 2006.

Bakaletz LO. "Moraxella catarrhalis and non-typable Haemophilus influenzae vaccines to prevent otitis media." In New Generation Vaccines. 4th ed ed. Edited by Levine, M.M., Dougan, G., Good, M.F., Liu, M.A., Nabel, G.J., Nataro, J.P. and Rappuoli, R.. -. New York: Informa Healthcare, January 2009.

 

Degrees

1979 B.S., The Ohio State University

1981 M.S., The Ohio State University

1984 Ph.D., The Ohio State University

 

Editorial Activities

present Microbial Pathogenesis
present Journal of Virology
present Journal of Clinical Microbiology
present Immunology and Cell Biology
present European Journal of Epidemiology
present Clinical, Diagnostic and Laboratory Immunology
present Trends in Microbiology
present Science
present Scandinavian Journal of Infectious Diseases
present Pharmacological Research
present Journal of Bacteriology
present Clincial Microbiology and Infection
present Applied and Environmental Microbiology
present Annals of Otology, Rhinology and Laryngology
present American Journal of Otolaryngology
present Vaccine
present The Laryngoscope
present The Journal of Infectious Diseases
present Otolaryngology - Head and Neck Surgery
present PloS Pathogens
present Proceedings of National Academy of Sciences, U.S.A.
present Journal of the American Medical Association (JAMA)
present Antimicrobial Agents and Chemotherapy
present Ear, Nose and Throat Journal
2008 - present Infection and Immunity
2015 - present Frontiers in Immunology
 

Journal Articles

Atack JM, Srikhanta YN, Fox KL, Jurcisek JA, Clark TA, Boitano M, Power PM, Jen FE-C, McEwan AG, Grimmond SM, Smith AL, Barenkamp SJ, Korlach J, Bakaletz LO, Jennings MP. "A biphasic epigenetic switch controls immunoevasion, virulence and niche adaptation in nontypeable Haemophilus influenzae." Nat Commun. (January 0.): -.

Ompremcak LB, Rheins MS.. "Scanning electron microscopy of mouse ciliated oviduct and tracheal epithelium infected in vitro with Bordetella pertussis." Can J Microbiol. Vol. 29, (January 1982.): 415-420.

Bakaletz LO, Rheins MS.. "A whole-organ perfusion model of Bordetella pertussis adherence to mouse tracheal epithelium." In Vitro Cell Dev Biol. Vol. 21, no. 6. (January 1985.): 314-320.

Bakaletz LO, DeMaria TF, Lim DJ.. "Effect of preopsonization on phagocytosis of Haemophilus influenzae." Arch Otolaryngol. Vol. 113, no. 5. (January 1987.): 526-529.

Lim DJ, DeMaria TF, Bakaletz LO.. "Functional morphology of the tubotympanum related to otitis media: a review." Am J Otol. Vol. 8, no. 5. (January 1987.): 385-389.

Lim DJ, DeMaria TF, Bakaletz LO.. "Functional morphology of the tybotympanum related to otitis media." Adv Oto-rhino-laryngol. Vol. 37, (January 1987.): 21-25.

Bakaletz LO, DeMaria TF, Lim DJ.. "Phagocytosis and killing of bacteria by middle ear macrophages." Arch Otolaryngol. Vol. 113, no. 2. (January 1987.): 138-144.

Bakaletz LO, Hoepf TM, DeMaria TF, Lim, DJ.. "The effect of antecedent influenza A virus infection on the adherence of Hemophilus influenzae to chinchilla tracheal epithelium.." Am J Otolaryngol. Vol. 9, no. 3. (January 1988.): 127-134.

DeMaria TF, Enrique R, Dohar J, Bakaletz LO, Lim DJ.. "Beta 2-microglobulin in the middle ear effusions and sera from patients with chronic OME." Arch Otolaryngol. Vol. 114, no. 11. (January 1988.): 1259-1261.

Bakaletz LO, Tallan BM, Hoepf T, DeMaria TF, Birck HG, Lim DJ.. "Frequency of fimbriation of nontypable Haemophilus influenzae and its ability to adhere to chinchilla and human respiratory epithelium." Infect Immun. Vol. 56, no. 2. (January 1988.): 331-335.

Lim DJ, DeMaria TF, Bakaletz LO.. "Current concepts of pathogenesis of otitis media: a review." Acta Otolaryngol. Vol. S458, (January 1988.): 174-180.

DeMaria TF, Enrique R, Dohar J, Bakaletz LO, Lim DJ.. "Beta-2-microglobulin in the middle ear effusions and sera from patients with chronic OME." Arch Otolaryngol. Vol. 114, no. 11. (November 1988.): 1259-1261.

Bakaletz LO, Tallan BM, Andrzejewski WJ, DeMaria TF, Lim DJ.. "Immunological responsiveness of chinchillas to outer membrane and isolated fimbrial proteins of nontypeable Haemophilus influenzae." Infect Immun. Vol. 57, no. 10. (January 1989.): 3226-3229.

Ogra PL, Giebink GS, Barenkamp SJ, DeMaria TF, Juhn SK, Shurin PA, Andersson B, Bakaletz LO, Bernstein JM, Brinton CC.. "Recent advances in otitis media. Microbiology, immunology, biochemistry, and vaccination." Ann Otol Rhinol Laryngol. Vol. 139, (January 1989.): 23-32.

Bakaletz LO, Griffith SR, Lim DJ.. "Effect of prostaglandin E2 and bacterial endotoxin on the rate of dye transport in the Eustachian tube of the chinchilla.." Ann Otol Rhinol Laryngol. Vol. 98, no. 4 Pt 1. (January 1989.): 278-282.

Bakaletz LO, Ohashi Y, Demaria TF, Lim DJ.. "Effect of formalin-fixed Hemophilus influenzae and Streptococcus pneumoniae on dye transport by the chinchilla Eustachian tube." Acta Otolaryngol (Stockh). Vol. 107, no. 3-4. (January 1989.): 235-243.

Lim DJ, Coticchia JM, Ueno K, Heiselman FA, Bakaletz LO.. "Glycoconjugates in the chinchilla tubotympanum.." Ann Otol Rhinol Laryngol. Vol. 100, no. 11. (January 1991.): 933-943.

Liauw L, Lim DJ, Bakaletz LO, van Blitterswijk C.. "Effect of vitamin A on the growth and differentiation of rat external auditory canal epithelium in organ culture." Amer J Otolaryngol. Vol. 12, no. 2. (January 1991.): 67-75.

Gilsdorf JR, Chang HY, McCrea KW, Bakaletz LO.. "Comparison of hemagglutinating pili of Haemophilus influenzae type b with similar structures of nontypeable H. influenzae." Infect Immun. Vol. 60, no. 2. (February 1992.): 374-379.

Gilsdorf JR, Chang HY, McCrea KW, Bakaletz LO.. "Comparison of hemagglutinating pili of Haemophilus influenzae type b with similar structures of nontypeable H. influenzae." Infect Immun. Vol. 60, no. 2. (January 1992.): 374-379.

Bakaletz LO, Ahmed MA, Kolattukudy PE, Lim DJ, Forney LJ.. "Cloning and sequence analysis of a pilin-like gene from an otitis media isolate of nontypeable Haemophilus influenzae." J Infect Dis. Vol. 165 Suppl 1, (January 1992.): S201-S203.

DeMaria TF, Yamaguchi T, Bakaletz LO, Lim DJ.. "Serum and middle ear antibody response in the chinchilla during otitis media with effusion induced by nonviable nontypeable Haemophilus influenzae." J Infect Dis. Vol. 165 Suppl 1, (January 1992.): S196-S197.

Lim DJ, Bakaletz LO.. "An investigation of the molecular basis of nontypable Haemophilus influenzae adherence to mucosal epithelium." Rhinology, Supplement. Vol. 14, (January 1992.): 37-41.

Bakaletz LO, Daniels RL, Lim DJ.. "Modeling adenovirus type 1-induced otitis media in the chinchilla: effect on ciliary activity and fluid transport function of Eustachian tube mucosal epithelium." J Infect Dis. Vol. 168, no. 4. (January 1993.): 865-872.

Park K, Bakaletz LO, Coticchia JM, Lim DJ.. "Effect of influenza A virus on ciliary activity and dye transport function in the chinchilla Eustachian tube." Ann Otol Rhinol Laryngol. Vol. 102, no. 7. (January 1993.): 551-558.

Bakaletz LO, Barenkamp SJ.. "Localization of high molecular weight adhesion proteins of nontypable Haemophilus influenzae by immunoelectron microscopy." Infect Immun. Vol. 62, no. 10. (January 1994.): 4460-4468.

Sirakova T, Kolattukudy PE, Murwin D, Billy J, Leake E, Lim DJ, DeMaria TF, Bakaletz LO.. "The role of fimbriae expressed by nontypeable Haemophilus influenzae in the pathogenesis of and protection against otitis media and relatedness of the fimbrin subunit to outer membrane protein A." Infect Immun. Vol. 62, no. 5. (January 1994.): 2002-2020.

Suzuki K, Bakaletz LO.. "Synergistic effect of adenovirus type 1 and nontypeable Haemophilus influenzae in a chinchilla model of experimental otitis media." Infect Immun. Vol. 62, no. 5. (January 1994.): 1710-1718.

Hesseling SC, van Blitterswijk CA, Lim DJ, DeMaria TF, Bakaletz LO, Grote JJ.. "The effect of endotoxin on cultured rat middle ear epithelium, rat meatal epidermis and human keratinocytes." Amer J Otology. Vol. 15, no. 6. (January 1994.): 762-768.

Kunin CM, Hua T, Bakaletz LO, Guerrant RL.. "Effect of salicylate, bismuth, osmolytes, and tetracycline resistance on expression of fimbriae by Escherichia coli." Infect Immun. Vol. 62, no. 6. (January 1994.): 2178-2186.

Bakaletz LO.. "Viral potentiation of bacterial superinfection of the airway." Trends Microbiol. Vol. 3, no. 3. (January 1995.): 110-114.

Bakaletz LO, Murwin DM, Billy JM.. "Adenovirus serotype 1 does not act synergistically with Moraxella catarrhalis to induce otitis media in the chinchilla." Infect Immun. Vol. 63, no. 10. (January 1995.): 4188-4190.

Kunin CM, Tong H-H, Bakaletz LO.. "Effect of salicylate on expression of flagella by Escherichia coli, Proteus, Providencia and Pseudomonas." Infect Immun. Vol. 63, no. 5. (January 1995.): 1796-1799.

Karma PH, Bakaletz LO, Giebink GS, Mogi G, Rynnel-Dagöö B.. "Immunological aspects of otitis media with special reference to immunoprophylaxis of acute otitis media in infants and children." Intl J Ped Otolaryngol. Vol. 32, (January 1995.): S127-S134.

Miyamoto N, Bakaletz LO.. "Selective adherence of nontypeable H.influenzae (NTHi) to mucus or epithelial cells in the chinchilla Eustachian tube and middle ear." Microb Pathog. Vol. 21, no. 5. (January 1996.): 343-356.

Bakaletz LO, Holmes KA.. "Evidence of transudation of specific antibody into the middle ears of parenterally immunized chinchillas after an upper respiratory tract infection with adenovirus." Clin Diag Lab Immunol. Vol. 4, no. 2. (January 1997.): 223-225.

Bakaletz LO, Leake ER, Billy JM, Kaumaya PTP.. "Relative immunogenicity and efficacy of two synthetic chimeric peptides of fimbrin as vaccinogens against nasopharyngeal colonization by nontypeable Haemophilus influenzae in the chinchilla." Vaccine. Vol. 15, no. 9. (January 1997.): 955-961.

Holmes K, Bakaletz LO.. "Adherence of nontypeable H. influenzae promotes re-organization of the actin cytoskeleton in human or chinchilla epithelial cells in vitro." Microb Pathog. Vol. 23, no. 3. (January 1997.): 157-166.

Welling DB, Parnes LS, O'Brien B, Bakaletz LO, Brackmann DE, Hinojosa R.. "Particulate matter in the posterior semicircular canal." Laryngoscope. Vol. 107, no. 1. (January 1997.): 90-94.

Miyamoto N, Bakaletz LO.. "Kinetics of the ascension of NTHi from the nasopharynx to the middle ear of the chinchilla coincident with adenovirus-induced compromise." Microb Pathog. Vol. 23, no. 2. (January 1997.): 119-126.

Bakaletz LO, Post JC, Ehrlich GD.. "Blinded multiplex PCR analysis of middle ear and nasopharyngeal fluids recovered from experimental chinchilla models of single and mixed pathogen induced otitis media." Clin Diag Lab Immunol. Vol. 5, no. 2. (January 1998.): 219-224.

Bakaletz LO, Kennedy BJ, Novotny LA, Dequesne G, Cohen J, Lobet Y.. "Protection against development of otitis media induced by nontypeable H. influenzae by both active and passive immunization in a chinchilla model of viral-bacterial superinfection." Infect Immun. Vol. 67, no. 6. (January 1999.): 2746-2762.

Jiang A, Nagata N, Molina E, Bakaletz LO, Hawkins H, Patel JA.. "Fimbriae-mediated enhanced attachment of nontypeable Haemophilus influenzae to respiratory syncytial virus-infected respiratory epithelial cells." Infect Immun. Vol. 67, no. 1. (January 1999.): 187-192.

Novotny LA, Jurcisek JA, Bakaletz LO.. "Epitope mapping of the outer membrane protein P5-homologous fimbrin adhesin of nontypeable Haemophilus influenzae." Infect Immun. Vol. 68, no. 4. (January 2000.): 2119-2128.

Kennedy B, Novotny LA, Jurcisek JA, Lobet Y, Bakaletz LO.. "Passive transfer of antiserum specific for immunogens derived from a nontypeable Haemophilus influenzae adhesin and lipoprotein D prevents otitis media after heterologous challenge." Infect Immun. Vol. 68, no. 5. (January 2000.): 2756-2765.

Poolman JT, Bakaletz LO, Cripps A, Denoël P, Forsgren A, Kyd J, Lobet Y.. "Developing a nontypeable Haemophilus influenzae (NTHi) vaccine." Vaccine. Vol. 19, no. Suppl 1. (January 2000.): S108-.

Bakaletz LO.. "Peptide and recombinant antigens for protection against bacterial middle ear infection." Vaccine. Vol. 19, no. 17-19. (January 2001.): 2323-2328.

Visweswaraiah A, Novotny LA, Hjemdahl-Monsen EJ, Bakaletz LO, Thanavala Y.. "Tracking the tissue distribution of marker dye following intranasal delivery in mice and chinchillas: a multifactorial analysis of parameters affecting nasal retention." Vaccine. Vol. 20, no. 25-26. (January 2002.): 3209-3220.

Novotny LA, Pichichero ME, Denoel PA, Neyt C, Vanderschrick S, Dequesne G, Bakaletz LO.. "Detection and characterization of pediatric serum antibody to the OMP P5-homologous adhesin of nontypeable Haemophilus influenzae during acute otitis media." Vaccine. Vol. 20, no. 29-30. (January 2002.): 3590-3597.

Bakaletz LO, Juhn SK, Jung TTK, Li JD.. "Recent advances in otitis media. 5. Molecular biology and biochemistry.." Ann Otol Rhinol Laryngol. Supplement. Vol. 188, (March 2002.): 52-61.

Bakaletz LO, Barenkamp SJ, Eskola J, Green B, Gu X-X, Harada T, Heikkinen T, Karma P, Klein JO, Kurono Y, Mogi G, Murphy TF, Ogra PL, Patel JA, Suzuki M, Yamanaka N.. "Recent advances in otitis media. 7. Vaccine.." Ann Otol Rhinol Laryngol. Supplement. Vol. 188, (March 2002.): 82-94.

Alper CM, Andalibi A, Bakaletz LO, Buchman C, Cayé-Thomasen P, Hellstrom SOM, Herman P, Hermansson A, Hussl B, Iino Y, Kawauchi H, Paparella MM, Sando I, Swarts JD, Takasaka T. "Recent advances in otitis media. 4. Anatomy, cell biology, pathology, and animal models.." Ann Otol Rhinol Laryngol. Supplement. Vol. 188, (March 2002.): 36-51.

DeMaria TF, Bakaletz LO, ChonmaitreeT, Heikkinen T, Hurst DS, Kawauchi H, Kurono Y, Patel JA, Sih TM, Stenfors L-E, Suzuki M. "Recent advances in otitis media. 6. Microbiology and immunology.." Ann Otol Rhinol Laryngol. Supplement. Vol. 188, (March 2002.): 62-81.

Novotny LA, Bakaletz LO.. "The fourth surface-exposed region of the OMP P5-homologous adhesin of nontypeable H. influenzae is an immunodominant but non-protective decoy epitope." J Immunol. Vol. 71, no. 4. (January 2003.): 1978-1983.

Mason KM, Munson RS, Bakaletz LO.. "Nontypeable Haemophilus influenzae gene expression induced in vivo in a chinchilla model of otitis media." Infect Immun. Vol. 71, no. 6. (January 2003.): 3454-3462.

Kyd JM, Cripps AW, Novotny LA, Bakaletz LO.. "Efficacy of OMP26 and two P5-fimbrin derived immunogens to induce clearance of nontypeable Haemophilus influenzae from the rat middle ear and lungs as well as from the chinchilla middle ear and nasopharynx." Infect Immun. Vol. 71, no. 8. (January 2003.): 4691-4699.

Jurcisek JA, Durbin JE, Kusewitt DF, Bakaletz LO.. "Anatomy of the nasal cavity in the chinchilla." Cell, Tissues, Organs. Vol. 174, no. 3. (January 2003.): 136-152.

Harris RH, Wilk D, Bevins CL, Munson Jr RS, Bakaletz LO.. "Identification and characterization of a mucosal antimicrobial peptide expressed by the chinchilla (Chinchilla lanigera) airway." J Biol Chem. Vol. 279, no. 19. (January 2004.): 20250-20256.

Morton DJ, Bakaletz LO, Jurcisek JA, Van Wagoner TM, Seale TW, Whitby PW, Stull TL.. "Reduced severity of middle ear infection caused by NTHI lacking the hemoglobin/ hemoglobin-haptoglobin binding proteins (Hgp) in a chinchilla model of otitis media." Microb Pathog. Vol. 36, no. 1. (January 2004.): 25-33.

Munson Jr RS, Harrison A, Gillaspy A, Ray WC, Carson M, Armbruster D, Gipson J, Gipson M, Johnson L, Lewis L, Dyer DW, Bakaletz LO.. "Partial analysis of the genomes of two nontypeable Haemophilus influenzae otitis media isolates." Infect Immun. Vol. 72, no. 5. (January 2004.): 3002-3010.

Bakaletz LO.. "Developing animal models for polymicrobial diseases." Nat Rev Microbiol. Vol. 2, no. 7. (January 2004.): 552-568.

Ryan AF, Jung TTK, Juhn SK, Li J-D, Andalibi A, Lin J, Bakaletz LO, Post CJ, Ehrlich GD.. "Recent advances in otitis media. 4C. Interaction between middle ear and inner ear in otitis media." Ann Otol Rhinol Laryngol. Supplement. Vol. 194, (January 2005.): 56-59.

Ryan AF, Jung TTK, Juhn SK, Li J-D, Andalibi A, Lin J, Bakaletz LO, Post CJ, Ehrlich GD.. "Recent advances in otitis media. 4A. Molecular biology.." Ann Otol Rhinol Otolaryngol. Supplement. Vol. 194, (January 2005.): 42-49.

Murphy TF, Bakaletz LO, Kyd JM, Watson B, Klein DL.. "Vaccines for otitis media: proposals for overcoming obstacles to progress." Vaccine. Vol. 23, no. 21. (January 2005.): 2696-2702.

Giebink GS, Kurono Y, Bakaletz LO, Kyd JM, Barenkamp SJ, Murphy TF, Green B, Ogra PL, Gu X-X, Patel JA, Heikkinen T, Pelton SI, Hotomi M, Karma P.. "Recent advances in otitis media. 6. Vaccine." Ann Otol Rhinol Otolaryngol. Supplement. Vol. 194, (January 2005.): 86-103.

Lim DJ, Hermansson A, Hellstrom SO, Hussl B, Alper CM, Iino Y, Andalibi A, Jung TTK, Bakaletz LO, Kawauchi H, Buchman CA, Kerschner J, Caye-Thomasen P, Lin J, Chole RA, Merchant SN, Herman P, Paparella MM, Lee H-Y, Kang S-H.. "Recent advances in otitis media. 3. Animal models; anatomy and pathology; pathogenesis; cell biology and genetics." Ann Otol Rhinol Otolaryngol. Supplement. Vol. 194, (January 2005.): 31-41.

Harrison A, Dyer DW, Gillaspy A, Ray WC, Mungur R, Carson MB, Zhong H, Gipson J, Gipson M, Johnson LS, Lewis L, Bakaletz LO, Munson Jr. RS.. "The genomic sequence of an otitis media isolate of nontypeable Haemophilus influenzae: comparative study with H. influenzae serotype d, strain KW20." J Bacteriol. Vol. 187, no. 13. (January 2005.): 4627-4636.

Bakaletz LO, Baker BD, Jurcisek JA, Harrison A, Novotny LA, Bookwalter JE, Mungur R, Munson Jr RS.. "Demonstration of Type IV pilus expression and a twitching phenotype by Haemophilus influenzae." Infect Immun. Vol. 73, no. 3. (January 2005.): 1635-1643.

Jurcisek JA, Greiner L, Watanabe H, Zaleski A, Apicella MA, Bakaletz LO.. "The role of sialic acid and complex carbohydrate biosynthesis in biofilm formation by nontypeable Haemophilus influenzae in the chinchilla middle ear." Infect Immun. Vol. 73, no. 6. (January 2005.): 3210-3218.

Barenkamp SJ, Kurono Y, Ogra PL, Leiberman, A, Bakaletz LO, Murphy TF, Chonmaitree T, Patel JA, Heikkinen T, Sih TM, Hurst DS, St Geme 3rd JW, Kawauchi H, Stenfors L-E.. "Recent advances in otitis media. 5. Microbiology and immunology." Ann Otol Rhinol Laryngol. Supplement. Vol. 194, (January 2005.): 60-85.

Ryan AF, Jung TTK, Juhn SK, Li J-D, Andalibi A, Lin J, Bakaletz LO, Post CJ, Ehrlich GD.. "Recent advances in otitis media. 4B. Biochemistry." Ann Otol Rhinol Laryngol. Supplement. Vol. 194, (January 2005.): 50-55.

Mason KM, Munson Jr RS, Bakaletz LO.. "A mutation in the sap operon attenuates survival of nontypeable Haemophilus influenzae in a chinchilla model of otitis media." Infect Immun. Vol. 73, no. 1. (January 2005.): 599-608.

Novotny LA, Mason KM, Bakaletz LO.. "Development of a chinchilla model to allow direct, continuous, biophotonic imaging of bioluminescent nontypeable Haemophilus influenzae during experimental otitis media." Infect Immun. Vol. 73, no. 1. (January 2005.): 609-611.

Gitiban N, Jurcisek JA, Harris RH, Mertz S, Durbin RK, Bakaletz LO, Durbin JE.. "Chinchilla and murine models of upper respiratory tract infection with respiratory syncytial virus." J Virol. Vol. 79, no. 10. (January 2005.): 6035-6042.

Avadhanula A, Rodriguez CA, Ulett GC, Bakaletz LO, Adderson EE.. "Nontypeable Haemophilus influenzae adheres to intercellular adhesion molecule 1 (ICAM-1) on respiratory epithelial cells and upregulates ICAM-1 expression." Infect Immun. Vol. 74, no. 2. (January 2006.): 830-838.

Wang HH, Manuzon M, Lehman M, Wan K, Luo H, Wittum TE, Yousef A, Bakaletz LO.. "Food commensal microbes as a potentially important avenue in transmitting antibiotic resistance genes." FEMS Microb Lett. Vol. 254, no. 2. (January 2006.): 226-231.

Mason KM, Bruggeman ME, Munson Jr RS, Bakaletz LO.. "The nontypeable Haemophilus influenzae Sap transporter provides a mechanism of antimicrobial peptide resistance and SapD-dependent potassium acquisition." Mol Microbiol. Vol. 62, no. 5. (January 2006.): 1357-1372.

Novotny LA, Jurcisek JA, Godfroid F, Poolman JT, Denoel PA, Bakaletz LO.. "Passive immunization with human anti-protein D antibodies induced by polysaccharide protein D conjugates protects chinchillas against otitis media after intranasal challenge with Haemophilus influenzae." Vaccine. Vol. 24, no. 22. (January 2006.): 4804-4811.

Jurcisek JA, Bakaletz LO.. "Biofilms formed by nontypeable Haemophilus influenzae in vivo contain both double-stranded DNA and type IV pilin protein." J Bacteriol. Vol. 189, no. 10. (January 2007.): 3868-3875.

Luke NR, Jurcisek JA, Bakaletz LO, Campagnari AA.. "Contribution of Moraxella catarrhalis type IV pili to nasopharyngeal colonization and biofilm formation." Infect Immun. Vol. 75, no. 12. (January 2007.): 5559-5564.

Bakaletz LO.. "Bacterial biofilms in otitis media: evidence and relevance." Pediatr Infect Dis J. Vol. 26, no. 10 Suppl. (January 2007.): S17-S19.

McGillivary G, Ray WC, Bevins CL, Munson Jr RS, Bakaletz LO.. "A member of the cathelicidin family of antimicrobial peptides is produced in the upper airway of the chinchilla and its mRNA expression is altered by common viral and bacterial co-pathogens of otitis media." Mol Immunol. Vol. 44, no. 9. (January 2007.): 2446-2458.

Harrison A, Ray WC, Baker BD, Armbruster DW, Bakaletz LO, Munson Jr RS.. "The OxyR regulon in nontypeable Haemophilus influenzae." J Bacteriol. Vol. 189, no. 3. (January 2007.): 1004-1012.

Jewell NA, Vaghefi N, Mertz SE, Akter P, Peebles Jr RS, Bakaletz LO, Durbin RK, Flano E, Durbin JE.. "Differential type I interferon induction by respiratory syncytial virus and influenza a virus in vivo." J Virol. Vol. 81, no. 18. (January 2007.): 9790-9800.

Hong W, Mason KM, Jurcisek JA, Novotny LA, Bakaletz LO, Swords WE.. "Phosphorylcholine decreases early inflammation and promotes the establishment of stable biofilm communities of nontypeable Haemophilus influenzae strain 86-028NP in a chinchilla model of otitis media." Infect Immun. Vol. 75, no. 2. (January 2007.): 958-965.

Jurcisek JA, Bookwalter JE, Baker BD, Fernandez S, Novotny LA, Munson RS Jr, Bakaletz LO.. "The PilA protein of non-typeable Haemophilus influenzae plays a role in biofilm formation, adherence to epithelial cells and colonization of the mammalian upper respiratory tract." Mol Microbiol. Vol. 65, no. 5. (January 2007.): 1288-1299.

McGillivary G; Bakaletz LO. "Innate immune defenses: finding a new way to calm the storm.." Immunol Cell Biol. Vol. 86, no. 8. (January 2008.): 639-.

McGillivary G, Bakaletz LO. "Innate immune defenses: finding a new way to calm the storm." Immunol Cell Biol. Vol. 86, no. 8. (January 2008.): 639-640.

Bookwalter JE, Jurcisek JA, Gray-Owen SD, Fernandez S, McGillivary G, Bakaletz LO.. "Spotlight." Infect Immun. Vol. 76, no. 1. (January 2008.): 21-.

Novotny LA, Partida-Sanchez S, Munson Jr RS, Bakaletz LO.. "Differential uptake and processing of a Haemophilus influenzae P5-derived immunogen by chinchilla dendritic cells." Infect Immun. Vol. 76, no. 3. (January 2008.): 967-977.

Bookwalter JE, Jurcisek JA, Gray-Owen SD, Fernandez S, McGillivary G, Bakaletz LO.. "A carcinoembryonic antigen-related cell adhesion molecule 1 homologue plays a pivotal role in nontypeable Haemophilus influenzae colonization of the chinchilla nasopharynx via the OMP P5-homologous adhesin." Infect Immun. Vol. 76, no. 1. (January 2008.): 48-55.

McGillivary G, Mason KM, Jurcisek JA, Peeples ME, Bakaletz LO. "Respiratory syncytial virus-induced dysregulation of expression of a mucosal beta-defensin augments colonization of the upper airway by non-typeable Haemophilus influenzae." Cell Microbiol. Vol. 11, no. 9. (January 2009.): 1399-1408.

Morton DJ, Seale TW, Bakaletz LO, Jurcisek JA, Smith A, VanWagoner TM, Whitby PW, Stull TL. "The heme-binding protein (HbpA) of Haemophilus influenzae as a virulence determinant." Int J Med Microbiol. Vol. 299, no. 7. (January 2009.): 479-488.

Murphy TF, Faden H, Bakaletz LO, Kyd JM, Forsgren A, Campos J, Virji M, Pelton SI. "Nontypeable Haemophilus influenzae as a pathogen in children." Pediatr Infect Dis J. Vol. 28, no. 1. (January 2009.): 43-48.

Novotny LA, Adams LD, Kang DR, Wiet GJ, Cai X, Sethi S, Murphy TF, Bakaletz LO. "Epitope mapping immunodominant regions of the PilA protein of nontypeable Haemophilus influenzae (NTHI) to facilitate the design of two novel chimeric vaccine candidates." Vaccine. Vol. 28, no. 1. (January 2009.): 279-289.

Bakaletz LO. "Chinchilla as a robust, reproducible and polymicrobial model of otitis media and its prevention.." Expert Rev Vaccines. Vol. 8, no. 8. (January 2009.): 1063-1082.

Murphy TF, Bakaletz LO, Smeesters PR. "Microbial interactions in the respiratory tract." Pediatr Infect Dis J. Vol. 28, no. 10 Suppl. (January 2009.): S121-.

Grieves JL, Jurcisek JA, Quist B, Durbin RK, Peeples ME, Durbin JE, Bakaletz LO. "Mapping the anatomy of respiratory syncytial virus infection of the upper airways in chinchillas (Chinchilla lanigera)." Comp Med. Vol. 60, no. 3. (January 2010.): 225-.

McGillivary G, Bakaletz LO. "The multifunctional host defense peptide SPLUNC1 is critical for homeostasis of the mammalian upper airway." PLoS One. Vol. 5, no. 10. (October 2010.): e13224-.

Bakaletz LO. "Immunopathogenesis of polymicrobial otitis media.." J Leukoc Biol. Vol. 87, no. 2. (January 2010.): 213-.

Jurcisek JA, Dickson AC, Bruggeman ME, Bakaletz LO. "In vitro biofilm formation in an 8-well chamber slide." J Vis Exp. Vol. 47, (January 2011.): doi: 10.3791/2481-.

Kolappan S; Tracy EN; Bakaletz LO; Munson Jr RS; Craig L. "Expression, purification, crystallization and preliminary crystallographic analysis of PilA from the nontypeable Haemophilus influenzae type IV pilus." Acta Crystallographica. (January 2011.): -.

Johnson RW, McGillivary G, Denoël P, Poolman J, Bakaletz LO. "Abrogation of nontypeable Haemophilus influenzae protein D function reduces phosphorylcholine decoration, adherence to airway epithelial cells, and fitness in a chinchilla model of otitis media.." Vaccine. Vol. 29, no. 6. (January 2011.): 1211-1221.

Goodman SD, Obergfell KP, Jurcisek JA, Novotny LA, Downey JS, Ayala EA, Tjokro N, Li B, Justice SS, Bakaletz LO. "Biofilms can be dispersed by focusing the immune system on a common family of bacterial nucleoid-associated proteins.." Mucosal Immunol. Vol. 4, no. 6. (January 2011.): 625-.

Underwood M, Bakaletz LO. "Innate immunity and the role of defensins in otitis media." Current Allergy And Asthma Reports. Vol. 11, no. 6. (January 2011.): 499-.

Novotny LA, Clements JD, Bakaletz LO. "Transcutaneous immunization as preventative and therapeutic regimens to protect against experimental otitis media due to nontypeable Haemophilus influenzae." Mucosal Immunol. Vol. 4, no. 4. (January 2011.): 456-.

Mason KM, Raffel FK, Ray WC, Bakaletz LO. "Heme utilization by nontypeable Haemophilus influenzae is essential and dependent on Sap transporter function." J Bacteriol. Vol. 193, no. 10. (January 2011.): 2527-.

Harrison, A; Bakaletz, LO; Munson Jr, RS. "Haemophilus influenzae and oxidative stress." Front Cell Inf Microbio. Vol. 2, (March 2012.): doi: 10.3389/fcimb.2012.00040-.

Hoopman T, Liu W, Joslin S, Pybus C, Sedillo J, Labandeira-Rey M, Laurence C, Wang W, Richardson J, Bakaletz LO, Hansen E. "Use of the chinchilla model for nasopharyngeal colonization to study gene expression by Moraxella catarrhalis." Infect Immun. Vol. 80, no. 3. (March 2012.): 982-.

Bakaletz LO. "Bacterial biofilms in the airway – evidence for role in pathology and implications for treatment.." Paediatr Respir Rev. (January 2012.): -.

Carruthers MD; Tracy EN; Dickson AD; Ganser K; Munson Jr RS; Bakaletz LO. "Nontypeable Haemophilus influenzae type IV pili: biological roles of the products encoded by the pil and com operons." J Bacteriol. (January 2012.): -.

Kolappan S, Tracy EN, Bakaletz LO, Munson Jr RS, Craig L. "Expression, purification, crystallization and preliminary crystallographic analysis of PilA from the nontypeable Haemophilus influenzae type IV pilus." Acta Crystallographica. Vol. F68, (March 2012.): 284-.

Harrison A, Bakaletz LO, Munson Jr, RS.. "Haemophilus influenzae and oxidative stress." Front Cell Inf Microbio. Vol. 2, no. 40. (March 2012.): doi: 10.3389/fcimb.2012.00040-.

Carruthers MD, Tracy EN, Dickson AC, Ganser K, Munson Jr RS, Bakaletz LO. "Nontypeable Haemophilus influenzae type IV pili: biological roles of the products encoded by the pil and com operons." J Bacteriol. Vol. 194, no. 8. (February 2012.): 1927-1933.

Bakaletz, LO. "Bacterial biofilms in the airway – evidence for role in pathology and implications for treatment." Paediatr Respir Rev. Vol. 13, no. 3. (April 2012.): 154-159.

Brockson ME, Novotny LA, Jurcisek JA, McGillivary G, Bowers MR, Bakaletz LO.. "Respiratory Syncytial Virus Promotes Moraxella catarrhalis-Induced Ascending Experimental Otitis Media." PLoS One. Vol. 7, no. 6. (June 2012.): e40088-.

Novotny LA, Clements, JD, Bakaletz LO.. "Kinetic analysis and evaluation of the mechanisms involved in the resolution of experimental nontypeable Haemophilus influenzae-induced otitis media after transcutaneous immunization." Vaccine. Vol. 31, (July 2013.): 3417-3426.

Jones EA, McGillivary G, Bakaletz LO.. "Extracellular DNA within a Nontypeable Haemophilus influenzae-Induced Biofilm Binds Human Beta Defensin-3 and Reduces Its Antimicrobial Activity." J Innate Immun. Vol. 5, no. 1. (January 2013.): 24-38.

Gustave JE, Jurcisek JA, McCoy KS, Goodman SD, Bakaletz LO.. "Targeting bacterial integration host factor to disrupt biofilms associated with cystic fibrosis." J Cystic Fibrosis. Vol. 12, no. 4. (July 2013.): 384-389.

Dagan R, Leibovitz E, Greenberg D, Bakaletz LO, Givon-Lavi N. "Mixed pneumococcal - nontypeable Haemophilus influenzae otitis media is a distinct clinical entity with unique epidemiologic characteristics and pneumococcal serotype distribution." J Infect Dis. Vol. 208, no. 7. (July 2013.): 1152-1160.

Li J-D, Hermansson A, Ryan A, Bakaletz LO, Brown SD, Cheeseman MT, Juhn SK, Jung TTK, Lim DJ, Lim JH, Lin J, Moon S-K, Post JC. "Panel 4: Recent Advances in Otitis Media in Molecular Biology, Biochemistry, Genetics, and Animal Models." Otolaryngol Head Neck Surg. Vol. 148, (April 2013.): E52-E63.

Novotny LA, Amer AO, Brockson ME, Goodman SD, Bakaletz LO. "Structural Stability of Burkholderia cenocepacia Biofilms Is Reliant on eDNA Structure and Presence of a Bacterial Nucleic Acid Binding Protein.." PLoS One. Vol. 8, no. 6. (January 2013.): e67629-.

Pelton SI, Pettigrew MM, Barenkamp SJ, Godfroid F, Grijalva CG, Leach A, Patel J, Murphy TF, Selak A, Bakaletz LO. "Panel 6: Vaccines." Otolaryngol Head Neck Surg. Vol. 148, (April 2013.): E90-E101.

Brandstetter KA, Jurcisek JA, Goodman SD, Bakaletz LO, Das S. "Antibodies directed against integration host factor mediate biofilm clearance from nasopore." Laryngoscope. Vol. 123, no. 11. (May 2013.): 2626-2623.

McGillivary G, Jordan ZB, Peeples ME, Bakaletz LO.. "Replication of Respiratory Syncytial Virus Is Inhibited by the Host Defense Molecule Viperin." J Innate Immun. Vol. 5, no. 1. (January 2013.): 60-71.

Taneja N-K, Ganguly T, Bakaletz LO, Dubey P, Poole L, Deora R. "D-alanine modification of a protease-susceptible outer membrane component by the Bordetella pertussis dra locus promotes cellular adherence and resistance to antimicrobial peptides and PMN-mediated killing." J Bacteriol. Vol. 195, no. 22. (November 2013.): 5102-5111.

Kunthalert D, Novotny LA, Massa HM, Ulett GC, Bakaletz LO, Kyd JM, Cripps AW. "Epitope-specific immune recognition of the nontypeable Haemophilus influenzae outer membrane protein 26." Hum Vaccin Immunother. Vol. 9, no. 3. (March 2013.): 625-635.

Cywes-Bentley C, Skurnik D, Zaidi T, Roux D, DeOliveira RB, Garrett WS, Lu X, O'Malley J, Kinzel K, Zaidi T, Rey A, Perrin C, Fichorova RN, Kayatani AK, Maira-Litràn T, Gening ML, Tsvetkov YE, Nifantiev NE, Bakaletz LO, Pelton SI, Golenbock DT, Pier GB. "Antibody to a conserved antigenic target is protective against diverse prokaryotic and eukaryotic pathogens.." PNAS. Vol. 110, no. 24. (June 2013.): E2209-18.

Caye-Thomasen P, Hermansson A, Bakaletz LO, Hellstrom S, Kanzaki S, Kerschner J, Lim D, Lin J, Mason K, Spratley J. "Panel 3: Recent Advances in Anatomy, Pathology, and Cell Biology in Relation to Otitis Media Pathogenesis." Otolaryngol Head Neck Surg. Vol. 148, (April 2013.): E37-E51.

Abu Khweek A, Fernández Dávila NS, Caution K, Akhter A, Abdulrahman BA, Tazi M, Hassan H, Novotny LA, Bakaletz LO, Amer AO. "Biofilm-derived Legionella pneumophila evades the innate immune response in macrophages.." Front Cell Infect Microbiol. Vol. 3, (May 2013.): 18-.

Das S, Rosas LE, Jurcisek JA, Novotny LA, Bakaletz LO. "Improving patient care via development of a protein-based diagnostic test for microbe-specific detection of chronic rhinosinusitis." Laryngoscope. Vol. 124, no. 3. (March 2014.): 605-615.

Brockson ME, Novotny LA, Mokrzan EM, Malhotra S, Jurcisek JA, Akbar R, Devaraj A, Goodman SD, Bakaletz LO.. "Evaluation of the kinetics and mechanism of action of anti-integration host factor-mediated disruption of bacterial biofilms." Mol Microbiol. Vol. 93, no. 6. (September 2014.): 1246-1258.

Fox KL, Atack JM, Srikhanta YN, Eckert A, Novotny LA, Bakaletz LO, Jennings MP.. "Selection for Phase Variation of LOS Biosynthetic Genes Frequently Occurs in Progression of Non-Typeable Haemophilus influenzae Infection from the Nasopharynx to the Middle Ear of Human Patients." PLoS One. Vol. 9, no. 2. (February 2014.): e90505-.

Blakeway LV, Power PM, Jen FEC, Worboys SR, Boitano M, Clark TA, Korlach J, Bakaletz LO, Jennings MP, Peak IR, Seib KL. "ModM DNA methyltransferase methylome analysis reveals a potential role for Moraxella catarrhalis phasevarions in otitis media." FASEB J. Vol. 28, no. 12. (December 2014.): 5197-5207.

Blakeway LV, Power PM, Jen FE-C, Worboys SR, Boitano M, Clark TA, Korlach J, Bakaletz LO, Jennings MP, Peak IR, Seib KL.. "ModM DNA methyltransferase methylome analysis reveals a potential role for Moraxella catarrhalis phasevarions in otitis media." FASEB J. Vol. 28, no. 12. (December 2014.): 5197-5207.

Jones EA, Kananurak A, Bevins CL, Hollox EJ, Bakaletz LO.. "Copy Number Variation of the Beta Defensin Gene Cluster on Chromosome 8p Influences the Bacterial Microbiota within the Nasopharynx of Otitis-Prone Children." PLoS One. Vol. 9, no. 5. (May 2014.): e98269-.

Cho C, Chande A, Gakhar L, Bakaletz LO, Jurcisek JA, Ketterer M., Shao J, Gotoh K, Hunt J, O'Brien E, Apicella MA.. "Role of the nuclease of nontypeable Haemophilus influenzae in dispersal of organisms from biofilms." Infect Immun. Vol. 83, no. 3. (March 2015.): 950-957.

Novotny LA, Jurcisek JA, Ward MO, Jordan ZB, Goodman SD, Bakaletz LO. "Antibodies against the majority subunit of type IV pili disperse nontypeable Haemophilus influenzae biofilms in a LuxS-dependent manner and confer therapeutic resolution of experimental otitis media." Mol Microbiol. Vol. 96, no. 2. (April 2015.): 276-292.

Novotny LA, Clements JD, Bakaletz LO. "Therapeutic transcutaneous immunization with a bandaid vaccine resolves experimental otitis media." Clin Vaccine Immunol. Vol. 22, no. 8. (May 2015.): 867-874.

Atack JM, Winter LE, Jurcisek JA, Bakaletz LO, Barenkamp SJ, Jennings MP. "Selection and counterselection of Hia expression reveals a key role for phase-variable expression of Hia in infection caused by nontypeable Haemophilus influenzae." J Infect Dis. Vol. 212, no. 4. (February 2015.): 645-653.

Atack JM, Srikhanta YN, Fox KL, Jurcisek JA, Clark TA, Boitano M, Power PM, Jen FEC, McEwan AG, Grimmond SM, Smith AL, Barenkamp SJ, Korlach J, Bakaletz LO, Jennings MP. "A biphasic epigenetic switch controls immunoevasion, virulence and niche adaptation in nontypeable Haemophilus influenzae." Nat Commun. Vol. 6, (July 2015.): 7828-.

Devaraj A, Justice SS, Bakaletz LO, Goodman SD.. "DNABII proteins play a central role in UPEC biofilm structure." Mol Microbiol. Vol. 96, no. 6. (June 2015.): 1119-1135.

Dagan R, Pelton SI, Bakaletz LO, Cohen R. "Prevention of early episodes of otitis media by pneumococcal vaccines might reduce progression to complex disease." Lancet Infect Dis. Vol. 16, (April 2016.): 480-492.

Novotny LA, Bakaletz LO. "Intercellular adhesion molecule 1 serves as a primary cognate receptor for the type IV pilus of nontypeable Haemophilus influenzae." Cell Microbiol. Vol. 18, no. 8. (February 2016.): 1043-1055.

Idicula W, Jurcisek JA, Cass ND, Syed A, Goodman SD, Elmaraghy CA, Jatana K, Bakaletz LO. "Identification of biofilms in post-tympanostomy tube otorrhea." Laryngoscope. Vol. 126, no. 8. (January 2016.): 1946-1951.

Mokrzan EM, Ward MO Jr, Bakaletz LO. "Type IV pilus expression is upregulated in nontypeable Haemophilus influenzae biofilms formed at the temperature of the human nasopharynx." J Bacteriol. Vol. 198, no. 19. (April 2016.): 2169-2630.

Novotny LA, Jurcisek JA, Goodman SD, Bakaletz LO.. "Monoclonal antibodies against the DNA-binding tips of DNABII proteins disrupt biofilms in vitro and induce bacterial clearance in vivo." eBioMedicine. Vol. 10, (August 2016.): 33-44.

Brockman KL, Jurcisek JA, Atack JM, Srikhanta YN, Jennings MP, Bakaletz, LO.. "ModA2 phasevarion wwitching in nontypeable Haemophilus influenzae increases the severity of experimental otitis media." J Infect Dis. Vol. 214, no. 5. (September 2016.): 817-824.

Rocco CJ, Davey ME, Bakaletz LO, Goodman SD. "Natural antigenic differences in the functionally equivalent extracellular DNABII proteins of bacterial biofilms provide a means for targeted biofilm therapeutics." Cell Microbiol. Vol. doi: 10.1111/omi.12157, (March 2016.): doi: 10.1111/omi.12157-.

Shimoyama M, Smith JR, DePons J, Tutaj M, Khampang P, Hong W, Erbe C, Ehrlich G, Bakaletz LO, Kerschner J.. "Next-gen chinchilla – resource for an otolaryngology disease model." Database. Vol. doi: 10.1093/database/baw073, (May 2016.): doi: 10.1093/database/baw073-.

Gunn JS, Bakaletz LO, Wozniak DJ. "What is on the outside matters: the role of the extracellular polymeric substance of Gram-negative biofilms in evading host immunity and as a target for therapeutic intervention." J Biol Chem. Vol. 291, no. 24. (June 2016.): 12538-12546.

Bakaletz LO. "Viral-bacterial co-infection in the respiratory tract." Curr Opin Microbiol. Vol. 35, (February 2017.): 30-35.

Freire M, Young A, Devaraj A, Downey JS, Navarro J, Chen C, Bakaletz LO, Zadeh H, Goodman SD. "A bacterial biofilm induced oral osteolytic infection can be successfully treated by immuno-targeting an extracellular nucleoid associated protein." Mol Oral Microbiol. Vol. 32, no. 1. (February 2017.): 74-88.

 

Inventions and Patents

Goodman SD, Bakaletz LO. "Compositions and methods for the removal of biofilms." filed 2011, (patent pending), and Application No. 13/073,782

Bakaletz LO. Inventor. "Genes of an otitis media isolate of nontypeable Haemophilus influenzae." Issued 2009, (patent granted), and Application No. 11/770,447

Kolattukudy PE, Bakaletz LO, Sirakova T. Inventor. "DNA molecules which encode the fimbrin protein of Haemophilus influenzae." Issued 1998, (patent granted), and Application No. 08/457,997

Bakaletz LO, Kaumaya PTP. Inventor. "Synthetic chimeric fimbrin peptides." Issued 1998, (patent granted), and Application No. 08/460,502

Bakaletz LO, Kaumaya PTP. Inventor. "Synthetic chimeric fimbrin peptides." Issued 2002, (patent granted), and Application No. 09/148,711

Thanavala Y, Visweswaraiah A, Bakaletz LO, Novotny LA. Inventor. "Method for nasal application of a medicinal substance." Issued 2003, (patent granted), and Application No. 09/991,835

Kolattukudy PE, Bakaletz LO, Sirakova T. Inventor. "Otitis media vaccine." Issued 2003, (patent granted), and Application No. 09/451,184

Bakaletz LO, Kaumaya PTP. Inventor. "Synthetic chimeric fimbrin peptides." Issued 2007, (patent granted), and Application No. 10/223,711

Bakaletz LO, Munson RS. Inventor. "Nontypeable H influenzae virulence factors." Issued 2007, (patent granted), and Application No. 10/807,746

Bakaletz LO, Munson RS. "Haemophilus influenzae type IV pili." Issued 2009, (patent granted), and Patent No. 7,501,131

Bakaletz LO, Munson RS. "Nontypeable Haemophilus influenzae virulence factors." Issued 2010, (patent granted), and Patent No. 7,723,504

Bakaletz LO, Kaumaya PTP. "Methods for reducing nasopharyngeal colonization of non-typable Haemophilus influenzae with synthetic chimeric fimbrin peptides." Issued 2010, (patent granted), and Patent No. 7,790,172

Bakaletz LO, Munson RS. "Chimeric vaccine for H. influenzae-induced disease." Issued 2010, (patent granted), and Patent No. 7,811,591

Bakaletz LO, Berthet F-X J, Denoel P, Poolman J, Thonnard J. "Haemophilus influenzae outer membrane protein and use thereof in vaccination." Issued 2010, (patent granted), and Patent No. 7,811,590

Bakaletz LO, Munson RS, Dyer DW. "Genes of an otitis media isolate of nontypeable H. influenzae." Issued 2010, (patent granted), and Patent No. 7,816,086

Bakaletz LO, Munson RS. "Haemophilus influenzae type IV pili." Issued 2011, (patent granted), and Patent No. 7,893,237

Bakaletz LO, Munson RS. "Nontypeable H. influenzae virulence factors." Issued 2011, (patent granted), and Patent No. 7,901,692

Bakaletz LO, Munson RS, Dyer DW. "Genes of an otitis media isolate of nontypeable Haemophilus influenzae." Issued 2011, (patent granted), and Patent No. 7,998,490

Bakaletz LO, Munson RS, Dyer DW. Inventor. "Polypeptide encoded by a nucleotide sequence of a nontypeable strain of Haemophilus influenzae." Issued 2007, (patent granted), and Application No. 10/795,159

Kolattukudy PE, Bakaletz LO, Sirakova T. Inventor. "Method for preparing the fimbrin protein of H. influenzae." Issued 2000, (patent granted), and Application No. 08/467,722

 

Presentations

"“Middle ear host defense and otitis media”." Presented at Gordon Research Conference, Ventura. (March 2009)

"“Targeting a Haemophilus influenzae protein expressed during biofilm growth in vivo for development of a vaccine for otitis media”.." Presented at 5th ASM Conference on Biofilms, Cancun, MX|MEX. (November 2009)

"“Updates to our understanding of the pathogenesis of otitis media caused by nontypeable Haemophilus influenzae and recent development in approaches for prevention”.." Presented at 6th Extraordinary International Symposium on Recent Advances in Otitis Media,, Seoul. (May 2009)

"“Role of the type IV pilus of nontypeable H. influenzae in the pathogenesis of otitis media and prospects for anti-PilA mediated treatment or prevention”." Presented at Molecular Virology and Microbiology 5th Annual Retreat, . (May 2009)

"“Mechanisms by which upper respiratory tract viruses predispose to otitis media due to nontypeable Haemophilus influenzae”.." Presented at 2nd Co-Infections Meeting, Memphis. (May 2009)

"“Feasibility of intranasal immunization against nontypeable Haemophilus influenzae-induced otitis media”.." Presented at 6th Extraordinary International Symposium on Recent Advances in Otitis Media, Seoul. (May 2009)

"“Role of innate immunity in the pathogenesis and prevention of otitis media due to nontypeable Haemophilus influenzae." Presented at US Japan ARI Panel Meeting, Chiba City, JP|JPN. (February 2009)

"Targeting the nontypeable Haemophilus influenzae biofilm for development of novel preventative and therapeutic vaccine candidates." Presented at University of Toronto Dean's Lecture Series, Toronto, CA|CAN. (March 2011)

 

Professional Activities

2010 - 2014 National Deafness and Other Communication Disorders Advisory Council. National Institutes of Health.