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Kristine Yoder, PhD


460 W 12th Ave
Columbus, OH 43210

Phone: (614) 688-2106

Email: yoder.176@osu.edu

 

Current OSU Appointment

Assistant Professor, SBS-Cancer Biology & Genetics

 

Noteworthy Graduate Narrative

Dissertation Advisor: Randi Mackler (2013-present)

Passed candidacy exam October, 2015

Co-author of a publication



Dissertation Advisor: Miguel Lopez (2016-present)

First author of a publication, Journal of Virological Methods

2016 OSU Distinguished University Fellowship

2016 Travel Scholarship, Society for the Advancement of Chicanos/Hispanics and Native Americans in Science Conference

2016 OSU COM CBG Fellowship

Research Funding

While at OSU, I have been PI to three R21 grants and one R01 as well as MPI to an additional R01. The funding I have been awarded is:

$3,037,500 total direct costs

$1,664,263 total indirect costs

$4,701,763 total funding (direct + indirect)



I was pleased that the score of my R21 awarded at the time of my tenure track appointment received a score of 11. My R01 was scored 8 percentile and the MPI R01 was scored 2 percentile.



Pending funding includes a diversity supplement for one R01 and an additional grant from the Campbell Foundation.

Master/Graduate Advising

I am the dissertation advisor for three current BSGP graduate students. One graduate student is expected to defend her thesis in 2018.



I currently serve on the dissertation committees for two graduate students in the College of Pharmacy, Ashley Hoyte and Jason Anderson.



I have been the graduate faculty representative for two dissertation defenses (2015 and 2016).

Undergraduate, Graduate, and Professional Courses Taught

BSGP 7000 Concepts in Biomedical Science (2014-2016, autumn semester)

IBGP 7000 Foundational Concepts in Biomedical Science (2012-2013, autumn semester)

This course changed name and designation after 2013.

This is the first course that I participated in teaching. It is a required introductory course for all BSGP and MSTP graduate students. Since 2012 I have been the first lecturer of the course, which includes the responsibility of demonstrating a paper presentation and discussion. The students are subsequently graded on their performance for presenting and leading a discussion, constituting 25% of their final grade. For 2012 and 2013 I presented 4 lectures (8 hours total) on the topic of DNA replication and repair. Since 2014 my lectures increased to 5 lectures (10 hours total). In all years I have written and graded one exam question. SEIs and peer review letters are provided for 2012-2015.



IBGP 7240/Microbiology 7724 Molecular Pathogenesis (2013, 2014, spring semester; 2015 autumn semester)

Due to lack of enrollment this course was not offered in 2016, but is planned for 2017.

I have taught 2 lectures (2 hours total) on RNA viruses and retroviruses since 2013. The graduate elective course covers many aspects of microbiology with only a few lectures on viruses. I wrote and graded 2 exam questions in 2013, 5 exam questions in 2014, and 4 exam questions in 2015. This survey course includes the participation of 22 faculty members and I have not been included on student evaluations of instruction. However a peer review letter from 2014 is provided.



MVIMG 7741 Molecular Virology and Pathogenesis of Viruses (2013, 2014, spring semester; 2015, autumn semester)

This graduate elective course is an in depth exploration of all viruses presented by 13 faculty members. In 2013 I joined the course as a module leader (of 7 modules) focusing on retroviruses. That year I presented 3 lectures (5.5 hours total) and supervised a postdoctoral fellow who presented an additional 3 lectures (5 hours total); I also wrote 4 exam questions. In 2014 and 2015 I taught six lectures of the module (10.5 hours total) and wrote 6 exam questions. Student evaluations were collected all three years and a peer evaluation for 2013. Anticipating my increased responsibilities as course director for BSGP 7000, I withdrew from participating in this course after 2015.

Academic Advising

2013 - present Randi Mackler, Ohio State University College of Medicine.
2016 - present Miguel Lopez, Ohio State University College of Medicine.
2006 Pia Hoellerbauer, Ohio State University College of Medicine. Graduated 2010.
2005 - 2007 William Roddick, Ohio State University College of Medicine. Graduated 2007.
2009 - 2011 Maureen McNulty, Ohio State University College of Medicine. Graduated 2010.
2009 - 2012 Geoffrey Bennett, Ohio State University College of Medicine. Graduated 2012. The Role of Base Excision Repair Proteins During HIV Infection
2010 - 2012 Ryan Peters, Ohio State University College of Medicine. Graduated 2011.
2012 Samantha Ohmer, Ohio State University College of Medicine. Graduated 0.
2013 Cassandra Skinner, Ohio State University College of Medicine. Graduated 2012.
2012 - 2015 Molly Osterhage, Ohio State University College of Medicine. Graduated 2015.
2015 Surabhi Tewari, The Ohio State University.
2015 Allison Lowery, The Ohio State University.
2014 - 2016 Mitchell Peake, The Ohio State University. Graduated 2016.
2016 Ishika Desai, The Ohio State University.
2016 Ashley Hicks, The Ohio State University. Graduated 0. Understanding correlates and comorbidities in the treatment and recovery of adolescent anorexia nervosa
 

Chapters in Books

PCR-based detection of the intestinal pathogen Cyclospora

 

Degrees

1993 B.S., Massachusetts Institute of Technology

2000 Ph.D., University of California San Diego

 

Editorial Activities

2007 Pharmaceutical Research
2010 - present Journal of Microbial & Biochemical Technology
2010 Journal of Virological Methods
2012 - present ISRN AIDS
2012 - present Journal of Virology & Antiviral Research
2012 Nucleic Acids Research
2013 PLoS ONE
2016 Nature Structural and Molecular Biology
 

Honors

1998 Outstanding teaching assistant. UCSD Biology Department.
2000 Outstanding teaching assistant. UCSD Biology Department.
 

Journal Articles

 

Reference Works

November 1995 Yoder, K, Kroes, I, Fredericks, D, Relman, D."Exploring the diversity of uncultivated microbial pathogens with amplified ribosomal DNA sequences" .
November 1999 Yoder, K, Bushman, F."Gap repair following retroviral integration" .
May 2000 Yoder, K, Bushman, F."Gap repair following retroviral integration" .
November 2004 Yoder, K, Sarasain, A, Kraemer, K, McIlhatton, M, Bushman, F, Fishel, R."Host DNA repair proteins affect HIV cDNA stability" .
January 2005 Yoder, K, Sarasain, A, Kraemer, K, McIlhatton, M, Bushman, F, Fishel, R."The DNA repair genes XPB and XPD defend cells from HIV integration" .
May 2005 Yoder, K, Sarasain, A, Kraemer, K, McIlhatton, M, Bushman, F, Fishel, R."The DNA repair genes XPB and XPD defend cells from HIV integration" .
May 2006 Yoder, K, Fishel, R."The DNA repair genes XPB and XPD participate in the degradation of retroviral cDNA" .
May 2007 Yoder, K, Roddick, W, Sarasin, A, Kraemer, K, Fishel, R."The host DNA repair proteins XPB an XPD medicate a novel host nuclear defense against retroviruses" .
May 2010 Yoder, K, Hoellerbauer, P, Roddick, W, Fishel, R."XPB/XPD participate in degradation of retroviral cDNA in the nucleus" .
April 2010 McNulty, M, Bennett, G, Fishel, R, Yoder, K."Effects of OGG1 and MYH glycosylases on HIV-1 integration site preference" .
May 2011 Bennett, G, McNulty, M, Peters, R, Naydinkiy, A, Fishel, R, Yoder, K."The role of base excison repair proteins during HIV infection" .
February 2014 Lopez, M., R. Mackler, M. Osterhage, and K. E. Yoder."The ins and outs of retroviral integration" .
September 2015 Peake, M., and K.E. Yoder."Characterization of the interaction between prototype foamy virus integrase and its target DNA." .
February 2015 Mackler, R, M Lopez, M Osterhage, M Peake, H Dashora, and K Yoder."Directing retroviral integration" .
March 2015 Peake, M, and K. Yoder."Reduction of HIV-1 infection through CRISPR/Cas9 disruption of viral DNA" .
October 2016 Lopez, M.A., Jones, N.D., Hanne, J., Peake, M.B., Lee, J-B., Fishel, R., and Yoder, K.E.."Retroviral Integration: A single molecule view" .
April 2016 Mackler, R, Mahto, S, Howard, C, Ottesen, J, Fishel, R. and Yoder, K."Determinants of Prototype Foamy Virus Integration Site Selection into Mononucleosomes" .
April 2016 Mackler, R, Mahto, S, Howard, C, Ottesen, J, Fishel, R. and Yoder, K."Determinants of Prototype Foamy Virus Integration Site Selection into Mononucleosomes" .
May 2016 Yoder, KE and Bundschuh, R.."Host double strand break repair generates HIV-1 strains resistant to CRISPR/Cas9" .
May 2016 Mackler, R, Mahto, S, Howard, C, Ottesen, J, Fishel, R. and Yoder, K."Determinants of Prototype Foamy Virus Integration Site Selection into Mononucleosomes" .
February 2016 Yoder, KE and Bundschuh, R.."Host double strand break repair generates HIV-1 strains resistant to CRISPR/Cas9" .
September 2016 Altman, M., Lopez, M., Mackler, R., and Yoder, K.E.."Exploring the Functions of the Domains of Prototype Foamy Virus Integrase" .
April 2017 Lopez Jr., M.A., Jones, N.D., Hanne, J., Peake, M.B., Lee, J-B., Fishel, R., and Yoder, K.E.."Real-Time Visualization of Retroviral Intasome Dynamics" .
April 2017 Mackler, R.M., Mahto, S.K., Jones, N.D., Lopez Jr., M.A., Altman, M.P., Senavirathne, P., Howard, C.J., Ottesen, J., Fishel, R., and Yoder, K.E.."Determinants of Prototype Foamy Virus Integration Site Selection into Mononucleosomes" .
Mackler, R.M., Lopez, M.A., Altman, M., and Yoder, K.E.."Roles of Prototype Foamy Virus Integrase Domains in Intasome Function" .

Softwares

December 2014 Yoder, KE."u.osu.edu/yoder.176" u.osu.edu
February 2016 Yoder, KE."u.osu.edu/retrovirologyjournal club"

Inventions and Patents

Provirus inactivation by double strand break induction

Zinc finger targeting of retroviral integrase

Genome editing with CRISPR/Cas9 to treat HIV-1 infection

 

Presentations

Gap repair following retroviral integration

Gap repair following retroviral integration

DNA repair proteins and HIV integration

DNA repair as a host defense against retroviral infection

The DNA repair genes XPB and XPD defend cells from HIV integration

DNA repair as a host defense against retroviral infection

DNA repair pathways defend the host genome from HIV integration

Metabolism of retroviral cDNA

Double strand break repair proteins and retroviruses

Host DNA repair pathways and retroviral cDNA

Host DNA repair pathways and retroviral cDNA

Retroviruses and DNA repair

DNA repair and HIV: Novel targets for therapy

Base excision repair and HIV integration

Host DNA repair and HIV: Viral agony and ecstasy

HIV integration and chromatin: Looking for a nice place to settle down

Host DNA repair and HIV: Viral agony and ecstasy

Retroviral Integration: Looking for a nice place to settle down

Can integration be more specifically targeted?

The Ins and Outs of Retroviral Integration

Retroviral Integration: A single molecule view

The ins and outs of retroviral integration: single molecule biophysical studies

DNA editing by ZFNs or CRISPR targeting HIV-1

Controlling HIV-1 with genome editing technologies

The ins and outs of retroviral integration

Host DNA repair and HIV: Viral agony and ecstasy

HIV strains resistant to CRISPR: Characterization of mutations

Single molecule analysis of retroviral integration strand transfer events

Dynamics of Retroviral Integration

PFV integration into nucleosomes

Retroviral Integration: Defining the search and disabling with CRISPR

PFV Integration to Mononucleosomes

PFV Integration into Mononucleosomes

Real-Time Visualization of Retroviral Intasome Dynamics

CRISPR targeting the HIV-1 provirus

 

Professional Activities

present Biotechnology and Safety Programme. Netherlands Organization for Scientific Research.
present Special emphasis panel, ZRG1 IDM-B. NIH.
2015 - present AIDS Walk Ohio Team "The Yoder Lab". AIDS Walk Ohio.
2014 - 2015 Presenter. OSU Molecular Genetics Undergraduate Club. Columbus, OH.
 

Unpublished Works

Prototype foamy virus integration to nucleosomes is dependent on the integrase carboxyl terminal domain

Retroviral integration and chromatin

Preparation of PCD for single molecule studies

Removal of a contaminating nuclease from recombinant PFV integrase

CRISPR targeting the HIV-1 provirus