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Kevin Mason, PhD


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700 Childrens Dr
Columbus, OH 43205

Phone: (614) 355-3534

Email: mason.40@osu.edu

 

Current OSU Appointment

Associate Professor, Pediatrics

 

Chapters in Books

Harrison A., and K.M. Mason. "Pathogenesis of Haemophilus influenzae in humans." In Emerging and Re-Emerging Human Infections. Vol. 2. Edited by S.S. Singh. 517-533. Hoboken: John Wiley & Sons/Wiley Blackwell Press, March 2016.

 

Degrees

1992 B.S., The Ohio State University

1998 Ph.D., Wright State University

 

Journal Articles

Mason K.M., Bigley N.J. and Fink P.S.. "Development of a novel in vitro co-culture system for studying host response to native bacterial antigens.." Journal of Immunological Methods. Vol. 211, no. 1-2. (February 1998.): 147-.

Curiel R.E., Mason K.M., Dryden T.D., Maurer M.J. and Bigley N.J.. "Cytokines produced early in picornavirus infection reflect resistance or susceptibility to disease." Journal of Interferon & Cytokine Research: The Official Journal of The International Society for Interferon and Cytokine Research. Vol. 18, no. 8. (August 1998.): 587-.

Mason K.M., Dryden T.D., Bigley N.J. and Fink P.S.. "Staphylococcal enterotoxin B primes cytokine secretion and lytic activity in response to native bacterial antigens." Infection and Immunity. Vol. 66, no. 11. (November 1998.): 5082-.

Mason K.M., Munson R.S. Jr. and Bakaletz L.O.. "Nontypeable Haemophilus influenzae gene expression induced in vivo in a chinchilla model of otitis media." Infection and Immunity. Vol. 71, no. 6. (June 2003.): 3454-.

Kesty N.C., Mason K.M., Reedy M., Miller S.E. and Kuehn M.J.. "Enterotoxigenic Escherichia coli vesicles target toxin delivery into mammalian cells." The EMBO Journal. Vol. 23, no. 23. (November 2004.): 4538-.

Mason K.M., Munson R.S. Jr, Bakaletz L.O.. "A mutation in the sap operon attenuates survival of nontypeable Haemophilus influenzae in a chinchilla model of otitis media." Infection and Immunity. Vol. 73, no. 1. (January 2005.): 599-.

Novotny L.A., Mason K.M. and Bakaletz L.O.. "Development of a chinchilla model to allow direct, continuous, biophotonic imaging of bioluminescent nontypeable Haemophilus influenzae during experimental otitis media." Infection and Immunity. Vol. 73, no. 1. (January 2005.): 609-.

Mason K.M., Bruggeman M.E., Munson R.S., Bakaletz L.O.. "The non-typeable Haemophilus influenzae Sap transporter provides a mechanism of antimicrobial peptide resistance and SapD-dependent potassium acquisition." Molecular Microbiology. Vol. 62, no. 5. (December 2006.): 1357-1372.

Kerschner J.E., Kawauchi H., Alper C.M., Lee H.Y., Stenfeldt K., Bakaletz L, Hellstrom S.O., Herman P., Hussl B., Iino Y., Mason K., Jung T., Chole R.A., Lim D.J., Lin J. and Paparella M. "Panel 3: Pathogenesis: Anatomy and Pathology, and cell biology." Recent Advances in Otitis Media. Vol. 1, (April 2007.): 40-.

Hong W., Mason K.M., Jurcisek J.A., Novotny L.A., Bakaletz L.O. and Swords W.E.. "Phosphorylcholine decreases early inflammation and promotes establishment of stable biofilm communities of NTHI strain 86-028NP in a chinchilla model of otitis media." Infection and Immunity. Vol. 2, no. 75. (January 2007.): 958-965.

McGillivary G., Mason K.M., Jurcisek J.A., Peeples M.E. and Bakaletz L.O.. "Respiratory syncytial virus-induced dysregulation of expression of a mucosal beta-defensin augments colonization of the upper airway by non-typeable Haemophilus influenzae." Cellular Microbiology. Vol. 11, no. 9. (September 2009.): 1399-1408.

Shelton, C.L., Raffel, F.K., Beatty, W.L., Johnson, S.M. and Mason K.M. "Sap transporter mediated import and subsequent degradation of antimicrobial peptides in Haemophilus." PLoS Pathogens. Vol. 7, no. 11. (November 2011.): E1002360-.

Mason K.M., Raffel F.K., Ray C.W. and Bakaletz L.O. "Heme utilization by nontypeable Haemophilus influenzae is essential and dependent on Sap transporter function." Journal of Bacteriology. Vol. 193, no. 10. (January 2011.): 2527-2535.

Sharpe S.W., Kuehn M.J. and Mason K.M. "Elicitation of epithelial-derived immune effectors by outer membrane vesicles of nontypeable Haemophilus influenzae." Infection and Immunity. Vol. 79, (August 2011.): 4361-4369.

Vogel A.R., Szelestey B.R., Raffel F.K., Sharpe S.W., Gearinger R.L., Justice S.S. and Mason K.M. "SapF-mediated heme-iron utilization enhances persistence and coordinates biofilm architecture of Haemophilus." Frontiers in cellular and infection microbiology. Vol. 2, (January 2012.): 42-.

Harrison A., Santana E.A., Szelestey B.R., Newsom D.E., White P. and Mason K.M. "Ferric uptake regulator and its role in the pathogenesis of nontypeable Haemophilus influenzae." Infection and Immunity. Vol. 81, no. 4. (April 2013.): 1221-1233.

Szelestey B.R, Heimlich D.R., Raffel F.K., Justice S.S. and Mason K.M. "Haemophilus Responses to Nutritional Immunity: Epigenetic and Morphological Contribution to Biofilm Architecture, Persistence and Disease." PLoS Pathogens. Vol. 9, no. 10. (October 2013.): e1003709-.

Cave-Thomasen P., Hermansson A., Bakaletz L., Hellstrom S., Kanzaki S., Kerschner J., Lin D., Mason K. and Spratley J. "Panel 3: Recent advances in anatomy, pathology and cell biology in relation to otitis media pathogenesis." Otolaryngol Head Neck Surg. Vol. 148, no. (Suppl 4). (April 2013.): E37-51.

Raffel F.K., Szelestey B.R., Beatty W.L. and Mason K.M. "The Haemophilus influenzae Sap transporter mediates bacterium-epithelial cell homeostasis." Infection and Immunity. Vol. 81, no. 1. (January 2013.): 43-54.

Caye-Thomasen P., Hermansson A., Bakaletz L., Hellstrom S., Kanzaki S., KerschnerJ., Lim D., Lin J., Mason K. and Spratley J. "Panel 3: Recent Advances in Anatomy, Pathology, and Cell Biology in Relation to Otitis Media Pathogenesis." Otolaryngology: Head and Neck Surgery. Vol. 148, (April 2013.): E37-E51.

Justice S.S., Harrison A., Beckness B. and Mason K.M.. "Bacterial differentiation, development and disease: mechanisms for survival." FEMS Microbiology Letters. Vol. 360, no. 1. (November 2014.): 1-8.

Heimlich D.R., Harrison A. and Mason K.M.. "Host antimicrobial peptides in bacterial homeostasis and pathogenesis of disease." Antibiotics. Vol. 3, no. 4. (December 2014.): 645-676.

Justice,Sheryl,S; Harrison,Alistair; Becknell,Brian; Mason,Kevin,M. "Bacterial differentiation, development, and disease: mechanisms for survival." FEMS MICROBIOLOGY LETTERS. Vol. 360, no. 1. (November 2014.): 1-8.

Pettigrew M.M., Alderson M.R., Bakaletz L.O., Barenkamp S.J., Hakansson A.P., Mason K.M., Nokso-Koivisto J., Patel J., Pelton S.I. and Murphy T.F. "Panel 6: Vaccines." Otolaryngology: Head and Neck Surgery. Vol. 1, (July 2016.): 1-.

Harrison A., Dubois L.G., St John-Williams L., Moseley M.A., Hardison R.L., Heimlich D.R., Stoddard A., Kerschner J.E., Justice S.S., Thompson J.W. and Mason K.M. "Comprehensive proteomic and metabolomic signatures of nontypeabble Haemophilus influenzae-induced acute otitis media reveal bacterial aerobic respirartion on an immunosuppressed environment." Molecular Cell Proteomics. Vol. 15, no. 3. (March 2016.): 1117-1138.

Horvath Jr. D.J., Patel A.S., Mohamed A., Storm D.W., Singh C., Li B., Zhang J., Koff S.A., Jayanthi V.R., Mason K.M. and Justice S.S. "Association of O-Antigen Serotype with the Magnitude of Initial Systemic Cytokine Responses and Persistence in the Urinary Tract." Journal of Bacteriology. Vol. 198, no. 6. (March 2016.): 964-972.

Sun D., Crowell S., Harding C.M., Fernando D.M., Mason K.M., Harrison A., Loewen P.C., Kumar A. and Liu Y. "KatG and KatE confer Acintobacter resisitance to hydrogen peroxide but sensitize bacteria to killing by phagocytic respiratory burst." Life Sciences. Vol. 148, (March 2016.): 31-40.

 

Reference Works

October 2010 Johnson, S.M., Shelton, C.L., Beatty, W.L., Raffel, F.K. and Mason, K.M.."Import and degradation of antimicrobial peptides as mechanisms of innate immune evasion in Haemophilus" St. Louis.

Inventions and Patents

Justice, S.S., Mason, K.M.. Co-Inventor. "LPS Serotypes for Determining Severity of Urinary Tract Infection." The Research Institute at Nationwide Children's Hospital (RINCH 2013-022). filed 2014, (patent pending), and Application No. International Patent Application No. PCT/US2014/070245, published as WO2015/089497 A2 on 06/18/2015

Mason, KM, Justice, SS, Harrison, A. Inventor. "Host Protein Response to Otitis Media." The Research Institute at Nationwide Children's Hospital (RINCH 2014-029). filed 2015, (patent pending), and Application No. International PCT Patent Application Number PCT/US2015/049645, published as WO 2016/040778 on 03/16

 

Professional Activities

2014 - 2015 Congressionally Directed Medical Research Programs (CDMRP), Department of Defense, Peer Reviewed Medical Research Program (2014, 2015).