Kathleen Boris-Lawrie, PhD

Current OSU Appointments

Professor, Veterinary Biosciences

Professor, SBS-Molec Vir, Imm & Med Gen

Academic Advising

MENTORED STUDENT AWARDSMelinda Butsch Ohio State University Graduate School Leadership Award 1997Melinda Butsch Kovacic, PhD NIH Epidemiology/Public Health, Cancer Prevention Fellowship, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 2002-2006 to earn MPH Harvard, 2003 and postdoctoral training NIH, Bethesda 2002-2006Stacey Hull First-Place, Poster Award Molecular and Cellular Biology Division, College of Veterinary Research Day, The Ohio State University, Columbus, OH. 1997Stacey Hull,PhD NIH T32 Postdoctoral Fellowship, University of CA, Irvine, CA. 2004-2006Tiffiney M. Roberts First-Place, Poster Award Biological Sciences Division, 13th Annual Edward H. Hayes Graduate Research Forum, The Ohio State University, Columbus, OH. 1998Tiffiney M. Roberts First-Place, Poster Award Molecular and Cellular Biology Division, College of Veterinary Research Day, The Ohio State University, Columbus, OH. 1999Tiffiney M. Roberts First-Place, Poster Award Molecular and Cellular Biology Division, College of Veterinary Research Day, The Ohio State University, Columbus, OH. 1999Tiffiney M. Roberts Second-Place, Roche Molecular Biochemicals Distinguished Seminar Award, The Ohio State University, Columbus, OH. 2000Tiffiney M. Hartman, PhD NIH T32 Postdoctoral Fellowship, Fox Chase Cancer Center, Philadelphia, PA. 2005Tiffiney M. Hartman, PhD NIH F32 Ruth L. Kirschstein National Research Service Award for Individual Postdoctoral Fellows, Fox Chase Cancer Center, Philadelphia, PA. 2006Cheryl Giles (Bolinger) Travel Award to attend and present poster at the Workshop on Post-Transcriptional Control by Oncogenic Viruses, Park City, Utah. 2005Cheryl Bolinger First-Place, Poster Award Molecular and Cellular Biology Division, College of Veterinary Research Day, The Ohio State University, Columbus, OH. 2006Cheryl Bolinger First-Place, Poster Award Molecular and Cellular Biology Division, College of Veterinary Research Day, The Ohio State University, Columbus, OH. 2007Cheryl Bolinger First-Place, Roche Molecular Biochemicals Distinguished Publication Award, The Ohio State University, Columbus, OH. 2008Nicole Placek Delta Gamma Foundation Graduate Fellowship Award 2003-2004 Nicole Placek Honorable Mention, Poster Award Molecular and Cellular Biology Division, College of Veterinary Research Day, The Ohio State University, Columbus, OH. 2004Nicole Placek Cold Spring Harbor Laboratory Travel Award to attend Eukaryotic mRNA Processing, Cold Spring Harbor, New York 2005Nicole Placek Selected Oral Presentation Rustbelt RNA Meeting, Mt. Sterling, OH 2005Nicole Placek Travel Award to attend and present poster at the Workshop on Post-Transcriptional Control by Oncogenic Viruses, Park City, Utah. 2005Nicole Placek First-Place, Poster Award Molecular and Cellular Biology Division, College of Veterinary Research Day, The Ohio State University, Columbus, OH. 2006Nicole Placek American Society for Cell Biology Travel Award to attend and present poster at “Cell Biology of HIV American Society for Cell Biology�, Atlanta, GA 2006Shuiming Qian Cold Spring Harbor Laboratory Travel Award to attend Eukaryotic mRNA Processing, Cold Spring Harbor, New York 2005Shuiming Qian Travel Award to Workshop on Post-Transcriptional Control by Oncogenic Viruses, Park City, Utah 2005Shuiming Qian First-Place, Roche Molecular Biochemicals Distinguished Publication Award, The Ohio State University, Columbus, OH. 2007Shuiming Qian The William J. Whelan Symposium Travel Fellowship Award to attend Regulatory RNA in biology and human health, Miami, Florida 2007Shuiming Qian First-Place, Roche Molecular Biochemicals Distinguished Publication Award, The Ohio State University, Columbus, OH. 2009Arnaz Ranji Glenn Barber Predoctoral Fellowship, College of Veterinary Medicine, Ohio State University (1% score) 2007-2010Arnaz Ranji First-Place, Roche Molecular Biochemicals Distinguished Seminar Award, The Ohio State University, Columbus, OH. 2007Arnaz Ranji First-Place, Poster Award Molecular and Cellular Biology Division, College of Veterinary Research Day, The Ohio State University, Columbus, OH. 2008Arnaz Ranji Travel Award, UCI/NIH Workshop Post-transcriptional Regulation of Viral Gene Expression, Virginia 2008Arnaz Ranji American Society for Virology Travel award to attend and present poster at 2009 annual meeting in Vancouver, BC, Canada 2009Arnaz Ranji American Society for Molecular Biology and Biochemistry award to attend and present poster and an invited talk at 2010 annual meeting in San Diego, CA 2010Amit Sharma American Heart Association Predoctoral fellowship (4% score) 2008-2010Amit Sharma Cold Spring Harbor Laboratories Travel award to attend and present poster to Retroviruses meeting, New York 2008Amit Sharma HIV Drug Resistance Symposium Travel award to attend and present poster, VirginiaCold Spring Harbor Retroviruses meeting selected for oral presentationPelotonia predoctoral fellowship, OSU CCC 2008Amit Sharma First-Place, Roche Molecular Biochemicals Distinguished Publication Award and Seminar Award, The Ohio State University, Columbus, OH. 2011Amit Sharma First-Place Graduate Student presentation, Cell Microbe Interface Biology Symposium, The Ohio State University, Columbus, OH. 2011J. Marcela Hernandez, PhD NIH T32 Cancer Genetics Postdoctoral Fellowship 2006-2009J. Marcela Hernandez, PhD Invited postdoctoral fellow keynote address, Annual Retreat Molecular Biology program of the Comprehensive Cancer Center 2008J. Marcela Hernandez, PhD NIH RO1 Supplement for Minority Postdoctoral Fellowship 2009-2011Wei Jing American Society for Virology Travel award to attend and present poster at 2009 annual meeting in Vancouver, BC, CanadaAward for poster presentation: Advances in Veterinary Medicine Day, Columbus Ohio 2009Sarah Fritz Glenn Barber Predoctoral Fellowship, College of Veterinary Medicine, Ohio State UniversityCell Microbe Interface NIH T32 FellowshipSchool Biomedical Sciences Fellow

Chapters in Books

Brown, D.P., J.S. Tuan, K.A. Boris, J.P. Dewitt, K.B. Idler, S.J. Chiang and L. Katz. "Plasmid-chromosome interaction in Saccharopolyspora erythraea and Streptomyceslividans." In Developments in Industrial Microbiology. Vol. 29. Edited by G. Pierce. 97-105. Washington, DC: Society of Industrial Microbiology, January 1988.

Hayes, A.M. and Boris-Lawrie, K.. "HIV-1 infection is a risk factor for malignancy." In Cancer Associated Viruses. Edited by E. Robertson. -. New York City: Springer Press, January 2012.

Conferences

Galvin, M., K.A. Boris, and M. Lev.. "Cloning and expression of the first gene of the sphingolipid biosynthetic pathway from Bacteroides levii into E. coli." In Federation of American Societies for Experimental Biology. (January 1985). 1066-.

Journal Articles

Katz, L., D. Brown, K.A. Boris and J. Tuan. "Expression of the MLS resistance methylase gene, ermE, from Streptomyces erythreus in Escherichia coli results in N6- monomethylation or N6, N6-dimethylation of ribosomal RNA." Gene. Vol. 55, (January 1987.): 319-325.

Boris-Lawrie,K,A; Brady,J,N; Kumar,A. "Sequences within the R region of the long terminal repeat activate basal transcription from the HIV-1 promoter.." Gene expression. Vol. 2, no. 3. (January 1992.): 215-230.

BOHAN,C,A; Kashanchi,F; Ensoli,B; Buonaguro,L; Boris-Lawrie,K,A; Brady,J,N. "Analysis of Tat transactivation of human immunodeficiency virus transcription in vitro.." Gene expression. Vol. 2, no. 4. (January 1992.): 391-407.

Boris-Lawrie,K,A; TEMIN,H,M. "Recent advances in retrovirus vector technology.." Current opinion in genetics & development. Vol. 3, no. 1. (February 1993.): 102-109.

Boris-Lawrie, K; Temin, H M. "The retroviral vector. Replication cycle and safety considerations for retrovirus-mediated gene therapy.." Annals of the New York Academy of Sciences. Vol. 716, (January 1994.): 59-70; discussion 71.

BORISLAWRIE,K; TEMIN,H,M. "GENETICALLY SIMPLER BOVINE LEUKEMIA-VIRUS DERIVATIVES CAN REPLICATE INDEPENDENTLY OF TAX AND REX." Journal of virology. Vol. 69, no. 3. (March 1995.): 1920-1924.

BORISLAWRIE,K; Altanerova,V; Altaner,C; Kucerova,L; TEMIN,H,M. "In vivo study of genetically simplified bovine leukemia virus derivatives that lack tax and rex." Journal of virology. Vol. 71, no. 2. (February 1997.): 1514-1520.

Kucerova,L; Altanerova,V; Altaner,C; Boris-Lawrie,K. "Bovine leukemia virus structural gene vectors are immunogenic and lack pathogenicity in a rabbit model." Journal of virology. Vol. 73, no. 10. (October 1999.): 8160-8166.

Butsch,M; Hull,S; Wang,Y,L; Roberts,T,M; Boris-Lawrie,K. "The 5 ' RNA terminus of spleen necrosis virus contains a novel posttranscriptional control element that facilitates human immunodeficiency virus Rev/RRE-independent Gag production." Journal of virology. Vol. 73, no. 6. (June 1999.): 4847-4855.

Roberts, T.M. and K. Boris-Lawrie. "RU5 of spleen necrosis virus is a stimulatory sequence that enhances translation of nonviral reporter gene mRNA." Journal of Virology. Vol. 74, no. 17. (January 2000.): 8111-8118.

Roberts,T,M; Boris-Lawrie,K. "The 5 ' RNA terminus of spleen necrosis virus stimulates translation of nonviral mRNA." Journal of virology. Vol. 74, no. 17. (September 2000.): 8111-8118.

Butsch,M; Boris-Lawrie,K. "Translation is not required to generate virion precursor RNA in human immunodeficiency virus type 1-infected T cells." Journal of virology. Vol. 74, no. 24. (December 2000.): 11531-11537.

Pandya,S; Boris-Lawrie,K; Leung,N,J; Akkina,R; Planelles,V. "Development of an rev-independent, minimal simian immunodeficiency virus-derived vector system." Human gene therapy. Vol. 12, no. 7. (May 2001.): 847-857.

Boris-Lawrie,K; Roberts,T,M; Hull,S. "Retroviral RNA elements integrate components of post-transcriptional gene expression." Life sciences. Vol. 69, no. 23. (October 2001.): 2697-2709.

Altaner, C., V. Altanerova, D. Holicova and K. Boris-Lawrie. "Structural gene vector infection protects rabbits from bovine leukemia virus challenge." AIDS and Human Retroviruses. Vol. 17, no. 1. (January 2001.): O31-.

Dangel,A,W; Hull,S; Roberts,T,M; Boris-Lawrie,K. "Nuclear interactions are necessary for translational enhancement by spleen necrosis virus RU5." Journal of virology. Vol. 76, no. 7. (April 2002.): 3292-3300.

Butsch,M; Boris-Lawrie,K. "Destiny of unspliced retroviral RNA: ribosome and/or virion?." Journal of virology. Vol. 76, no. 7. (April 2002.): 3089-3094.

Hull,S; Boris-Lawrie,K. "RU5 of Mason-Pfizer monkey virus 5 ' long terminal repeat enhances cytoplasmic expression of human immunodeficiency virus type 1 gag-pol and nonviral reporter RNA." Journal of virology. Vol. 76, no. 20. (October 2002.): 10211-10218.

Hull,S; Boris-Lawrie,K. "Analysis of synergy between divergent simple retrovirus posttranscriptional control elements." Virology. Vol. 317, no. 1. (December 2003.): 146-154.

Ding,W; Kim,S,J; Nair,A,M; Michael,B; Boris-Lawrie,K; Tripp,A; Feuer,G; Lairmore,M,D. "Human T-cell lymphotropic virus type 1 p12(I) enhances interleukin-2 production during T-cell activation." Journal of virology. Vol. 77, no. 20. (October 2003.): 11027-11039.

Roberts,T,M; Boris-Lawrie,K. "Primary sequence and secondary structure motifs in spleen necrosis virus RU5 confer translational utilization of unspliced human immunodeficiency virus type 1 reporter RNA." Journal of virology. Vol. 77, no. 22. (November 2003.): 11973-11984.

Altanerova,V; Holicova,D; Kucerova,L; Altaner,C; Lairmore,M,D; Boris-Lawrie,K. "Long-term infection with retroviral structural gene vector provides protection against bovine leukemia virus disease in rabbits." Virology. Vol. 329, no. 2. (November 2004.): 434-439.

Altanerova, V., D. Holicova, L. Kucerova, C. Altaner, and K. Boris-Lawrie. "Long- term infection with bovine leukemia virus structural gene vector provides protection against BLV disease in rabbits." Virology. Vol. 329, (January 2004.): 434-439.

Michael,Bindhu; Nair,Amrithraj,M; Hiraragi,Hajime; Shen,Lei; Feuer,Gerold; Boris-Lawrie,Kathleen; Lairmore,Michael,D. "Human T lymphotropic virus type-1 p30II alters cellular gene expression to selectively enhance signaling pathways that activate T lymphocytes.." Retrovirology. Vol. 1, (January 2004.): 39-?.

Nair,A; Michael,B; Hiraragi,H; Fernandez,S; Feuer,G; Boris-Lawrie,K; Lairmore,M. "Human T lymphotropic virus type 1 accessory protein p12(I) modulates calcium-mediated cellular gene expression and enhances p300 expression in T lymphocytes." AIDS research and human retroviruses. Vol. 21, no. 4. (April 2005.): 273-284.

Yilmaz,A; Bolinger,C; Boris-Lawrie,K. "Retrovirus translation initiation: Issues and hypotheses derived from study of HIV-1." Current HIV research. Vol. 4, no. 2. (April 2006.): 131-139.

Younis,I; Boris-Lawrie,K; Green,P,L. "Human T-cell leukemia virus open reading frame II encodes a posttranscriptional repressor that is recruited at the level of transcription." Journal of virology. Vol. 80, no. 1. (January 2006.): 181-191.

Hartman,Tiffiney,Roberts; Qian,Shuiming; Bolinger,Cheryl; Fernandez,Soledad; Schoenberg,Daniel,R; Boris-Lawrie,Kathleen. "RNA helicase A is necessary for translation of selected messenger RNAs." Nature structural & molecular biology. Vol. 13, no. 6. (June 2006.): 509-516.

Zhong,Xuehua; Leontis,Neocles; Qian,Shuiming; Itaya,Asuka; Qi,Yijun; Boris-Lawrie,Kathleen; Ding,Biao. "Tertiary structural and functional analyses of a viroid RNA motif by isostericity matrix and mutagenesis reveal its essential role in replication." Journal of virology. Vol. 80, no. 17. (September 2006.): 8566-8581.

Hartman, T. R., Qian, S. Fernandez, S., Schoenberg, D.R. and Boris-Lawrie, K.. "RNA helicase A stimulates translation of selected mRNAs." Nature Structural and Molecular Biology. Vol. 13, no. 6. (May 2006.): 509-16.

Yilmaz,Alper; Fernandez,Soledad; Lairmore,Michael,D; Boris-Lawrie,Kathleen. "Coordinate enhancement of transgene transcription and translation in a lentiviral vector." Retrovirology. Vol. 3, (February 2006.): 13-.

Boris-Lawrie, K.. "Bridging fundamental RNA biology, retroviral replication, and oncogenesis: Karen Beemon wins the 2007 Retrovirology Prize." Retrovirology. Vol. 4, (January 2007.): 88-.

Bolinger,Cheryl; Yilmaz,Alper; Hartman,Tiffiney,Roberts; Kovacic,Melinda,Butsch; Fernandez,Soledad; Ye,Jianxin; Forget,Mary; Green,Patrick,L; Boris-Lawrie,Kathleen. "RNA helicase A interacts with divergent lymphotropic retroviruses and promotes translation of human T-cell leukemia virus type 1." Nucleic acids research. Vol. 35, no. 8. (April 2007.): 2629-2642.

Hernandez,J,M; Floyd,D,H; Weilbaecher,K,N; Green,P,L; Boris-Lawrie,K. "Multiple facets of junD gene expression are atypical among AP-1 family members." ONCOGENE. Vol. 27, no. 35. (August 2008.): 4757-4767.

Nadella,M,VP; Kisseberth,W,C; Nadella,K,S; Thudi,N,K; Thamm,D,H; McNiel,E,A; Yilmaz,A; Boris-Lawrie,K; Rosol,T,J. "NOD/SCID mouse model of canine T-cell lymphoma with humoral hypercalcaemia of malignancy: cytokine gene expression profiling and in vivo bioluminescent imaging." VETERINARY AND COMPARATIVE ONCOLOGY. Vol. 6, no. 1. (March 2008.): 39-54.

Bolinger,Cheryl; Boris-Lawrie,Kathleen. "Mechanisms employed by retroviruses to exploit host factors for translational control of a complicated proteome." RETROVIROLOGY. Vol. 6, (January 2009.): 8-.

Qian,Shuiming; Zhong,Xuehua; Yu,Lianbo; Ding,Biao; de Haan,Peter; Boris-Lawrie,Kathleen. "HIV-1 Tat RNA silencing suppressor activity is conserved across kingdoms and counteracts translational repression of HIV-1." PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. Vol. 106, no. 2. (January 2009.): 605-610.

Ranji,Arnaz; Boris-Lawrie,Kathleen. "RNA helicases Emerging roles in viral replication and the host innate response." RNA BIOLOGY. Vol. 7, no. 6. (November 2010.): 775-787.

Bolinger,Cheryl; Sharma,Amit; Singh,Deepali; Yu,Lianbo; Boris-Lawrie,Kathleen. "RNA helicase A modulates translation of HIV-1 and infectivity of progeny virions." NUCLEIC ACIDS RESEARCH. Vol. 38, no. 5. (March 2010.): 1686-1696.

Hayes,Amy,M; Qian,Shuiming; Yu,Lianbo; Boris-Lawrie,Kathleen. "Tat RNA silencing suppressor activity contributes to perturbation of lymphocyte miRNA by HIV-1." RETROVIROLOGY. Vol. 8, (May 2011.): 36-.

Ranji,Arnaz; Shkriabai,Nikolozi; Kvaratskhelia,Mamuka; Musier-Forsyth,Karin; Boris-Lawrie,Kathleen. "Features of Double-stranded RNA-binding Domains of RNA Helicase A Are Necessary for Selective Recognition and Translation of Complex mRNAs." JOURNAL OF BIOLOGICAL CHEMISTRY. Vol. 286, no. 7. (February 2011.): 5328-5337.

Jin,Jianyu; Jing,Wei; Lei,Xin-Xiang; Feng,Chen; Peng,Shuping; Boris-Lawrie,Kathleen; Huang,Yingqun. "Evidence that Lin28 stimulates translation by recruiting RNA helicase A to polysomes." Nucleic Acids Research. Vol. 39, no. 9. (May 2011.): 3724-3734.

Sharma,Amit; Boris-Lawrie,Kathleen. "Determination of host RNA helicases activity in viral replication.." Methods in enzymology. Vol. 511, (January 2012.): 405-435.

Sharma,Amit; Yilmaz,Alper; Marsh,Kim; Cochrane,Alan; Boris-Lawrie,Kathleen. "Thriving under Stress: Selective Translation of HIV-1 Structural Protein mRNA during Vpr-Mediated Impairment of eIF4E Translation Activity." PLOS PATHOGENS. Vol. 8, no. 3. (March 2012.): e1002612-.

Inventions and Patents

Kathleen Boris-Lawrie and Howard M. Temin. "Recombinant retroviruses and uses thereof." Filed September 1996.

Kathleen Boris-Lawrie. "More complex type retroviruses having mixed type LTR and Internal Ribosome Entry Sites." Filed June 1998.

Presentations

"Unspecified." Presented at XV European Association for Cancer Research Meeting, Stockholm, SE|SWE. (January 1998)

"Unspecified." Presented at Cold Spring Harbor Laboratory international Retroviruses meeting, . (January 2002)

"Workshop on Post-transcriptional Control by Oncogenic Viruses." Presented at Unspecified, Park City, UT. (January 2004)

"Unspecified." Presented at Cold Spring Harbor Laboratory international Retroviruses meeting, . (January 2004)

"Unspecified." Presented at 7th International Symposium on Predictive Oncology and Intervention Strategies: Cancer Detection and Prevention, Nice, FR|FRA. (January 2004)

"Molecular Determinants of HIV Pathogenesis." Presented at Keystone Symposium, BC, CA|CAN. (January 2004)

"Advances in Neuro-oncology: from Molecular Mechanisms of Carcinogenesis to Novel Therapeutic Approaches." Presented at 7th Comprehensive Cancer Center Annual Scientific Meeting, . (January 2005)

"Unspecified." Presented at Cancer 2006, 60th Anniversary Symposium Cancer Research Institute, Bratislava, SK|SVK. (January 2006)

"Unspecified." Presented at Cold Spring Harbor Laboratory international Retroviruses meeting, . (January 2006)

"Unspecified." Presented at Cancer 2006, 60th Anniversary Symposium Cancer Research Institute, Bratislava, SK|SVK. (January 2006)

"Cell Biology of HIV-1 and other Retroviruses." Presented at American Society of Cell Biology, Atlanta, GA. (January 2006)

"Cell Biology of HIV-1 and other Retroviruses." Presented at American Society of Cell Biology, Atlanta, GA. (January 2006)

"Session Novel Antiviral Strategies." Presented at Symposium on Antiviral Drug Resistance, Richmond, VA. (November 2007)

"Unspecified." Presented at Pathogen Host Standoff Meeting, National Cancer Institute, Bethesda, MD. (June 2007)

"Unspecified." Presented at Cold Spring Harbor Laboratory international Retroviruses meeting, . (January 2007)

"Workshop on Post-transcriptional Regulation of Viral Gene Expression." Presented at Unspecified, Syria, VA. (August 2008)

"Second Workshop on Post-transcriptional Regulation of Viral Gene Expression." Presented at Unspecified, Syria, VA. (August 2008)

"State-of-the-Art talk." Presented at American Society for Virology annual meeting, Vancouver, BC, CA|CAN. (July 2009)

"Unspecified." Presented at HIV-1 Nucleocapsid Symposium, Barcelona, ES|ESP. (September 2011)