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Jordi Torrelles, PhD


Staff photo

460 W 12th Ave
Columbus, OH 43210

Phone: (614) 292-0777

Email: torrelles.2@osu.edu

 

Current OSU Appointment

Associate Professor, SBS-Microbial Infectn/Immunity

 

Advising Narrative

- Varun Gadkari: 3rd Place for the best poster presentation under the category of undergraduate students in Biomedical Sciences, The Ohio State University 17th Annual Denman Undergraduate Research Forum, May 9th, 2012. Poster title: Human Lung Surfactant Hydrolases Alter the Mycobacterium tuberculosis Cell Surface Influencing the Human Macrophage Capacity to Control the Infection. Gadkari V, Arcos J, Sasindran SJ, Diangelo L, and Torrelles JB. The Ohio State University, Columbus, OH.

- Poornima Venigalla: 2013 Undergraduate Research Office (URO) Summer Fellowship (13 funded from 127 applications). Project: Receptor expression on immune cells in response to Mycobacterium tuberculosis exposed to human lung surfactant. This award is to perform basic research in my lab during the summer term. As stated in the award notification letter: "Poornima wrote a very compelling proposal and the letter from her research mentor demonstrates a deep commitment to her and her project".

- Poormina Venigalla: 2013 SOLAR Undergraduate Award (4 funded). Project: Receptor expression on immune cells in response to Mycobacterium tuberculosis exposed to human alveolar lining fluid.

- Poornima Venigalla: 2014 3rd Place for the best poster presentation under the category of undergraduate students in Biomedical Sciences, The Ohio State University 19th Annual Denman Undergraduate Research Forum, March 26th, 2014. Poster title: Receptor expression on immune cells in response to Mycobacterium tuberculosis exposed to human lung alveolar lining fluid (ALF). Venigalla P, Sasindran SJ, Arcos J, Moliva JI, and Torrelles JB. The Ohio State University, Columbus, OH.

- Poormina Venigalla: 2015 Accepted to American Corps for one year before going to Medical School.

- Lauren E. Diangelo: 2013 Accepted for Admission to The Ohio State University College of Veterinary Medicine. She is a co-author in a lab peer-reviewed publication, in one submitted and another in preparation.

-Sabeen Sidiki: 2013 Recipient of Federal Work-Study Program. Project: Enhancing the sensitivity of the Alere Determine Urine TB LAM Ag test to improve TB diagnosis in endemic areas.

- Sabeen Sidiki: 2014 Honorable Mention for the Medicine and the Arts Board, The Ohio State University College of Medicine Art Show. March 5th, 2014, Meiling Hall, Columbus, OH.

- Sabeen Sidiki: 2015 Recipient of OSU College of Public Health Dean's Award, The Ohio State University.

- Sabeen Sidiki: She is co-author in a peer-reviewed publication from the lab and in one submitted and two in preparation.

- Christine Fung: OSU Honors Program. Pelotonia Fellowship to perform research studies in Brazil. She also obtained funds to attend 1-year studies abroad in Japan before starting her studies in Medicine (I am her mentor within the OSU Honors Program. Her awards are related to studies in another lab).

Academic Advising

I am currently mentoring several post-doctoral, doctoral, masters, and undergraduate (including undergraduates within the OSU Honors Program) students as well as lab technical staff. In this regard, I have always my office door open to all the students/staff within my department and center seeking for research and/or personal advice. I was fortunate that during my doctoral and post-doctoral studies to have outstanding mentors from which I learnt how to become a scientist deeply implicated in education and research. As a faculty member, I am targeting the formation of a competitive and intellectual research group bringing new ideas and technology to the field. However, a part of directing a successful scientific program, one of my goals is to devote part of my time to teach young students/scientists and to transfer to them my knowledge and enthusiasm for science in order to enable them to move on to become successful scientists and academic scholars within the scientific community. This is noted in the large number of abstracts in my dossier, which reflects my enthusiasm in mentoring having my lab personnel (students and staff) presenting their data in local [i.e. OSU/COM Research day, Center for Microbial Interface Biology (CMIB) Retreat, Public Health Preparedness for Infectious Diseases (PHPID) Annual Retreat, The Dorothy M. Davis Heart and Lung Research Institute (DHLRI) Research Day], regional/national (i.e. Midwest Pathogenesis meeting, American Society for Microbiology (ASM), American Association of Immunologists (AAI)]; and international (i.e., Tuberculosis Keystone, Innate Immunity Keystone, Gordon Conferences) meetings. My believe is that learning how to present data (first writing an abstract and then presenting data, even in a poster format) is critical in the learning curve of any successful scientist.

Academic Advising

2011 - present , The Ohio State University.
1998 - 1999 , Colorado State University.
1998 - 2000 , Colorado State University.
2000 - 2001 , Colorado State University.
2001 - 2002 , Colorado State University.
2000 - 2003 , Colorado State University.
2001 - 2003 , Colorado State University.
2010 , The Ohio State University.
 

Chapters in Books

Determinants of phagocytosis, phagosome biogenesis and autophagy for Mycobacterium tuberculosis

Lipoglycans of Mycobacterium tuberculosis: isolation, purification, and characterization.

Broadening the view about the role of Mycobacterium tuberculosis cell envelope components during infection: A battle for survival

 

Conferences

On arabinan biosynthesis in arabinogalactan and lipoarabinomannan: The mycobacterial cell wall polysaccharides

Isoforms of lipoarabinomannan from Mycobacterium tuberculosis that are recognized by CDI-restricted T-cells: Their potential role in mediating immune responses in human

Subversion of the human CD1-restricted T cell repertoire in leprosy infection

Point mutations in EmbC affect synthesis of lipoarabinomannan in mycobacterium smegmatis

M. tuberculosis cell wall mannosylated lipoglycans: Elucidation of structural motifs that impact on human macrophage recognition and response.

Heterogeneity of cell wall carbohydrates and lipids from clinical isolates of Mycobacterium tuberculosis: Impact on interactions with the human host

A subset of Mycobacterium tuberculosis clinical isolates within a defined genetic linkage differentially interact with human macrophages due to a truncated lipoarabinomannan and reduced higher-order phosphatidyl-myo-inositol mannosides

Mycobacterium tuberculosis activates PPAR-gamma, a key regulator of human macrophage immune responses, through ligation of the mannose receptor.

Mycobacterium tuberculosis infection regulates the expression of microRNAs and regulates human macrophage immune responses

Glycopeptidolipids for evaluating the role of non-tuberculous mycobacteria in latent tuberculosis infection diagnosis

 

Degrees

1996 B.S., Universitat Autònoma of Barcelona

2000 M.S., Universitat Autònoma of Barcelona

2003 Ph.D., Universitat Autònoma of Barcelona

 

Editorial Activities

2001 - present Tuberculosis
2006 - present FEMs Immunology and Clinical Microbiology
2007 - present Molecular Microbiology
2008 - present Glycobiology
2008 - present Journal of Immunology
2009 - present Drugs od the future
2009 - present Journal of Leukocyte Biology
2009 - present Journal of Biological Chemistry
2010 - present Journal of Glycomics and Lipidomics
2010 - present Frontiers in Cellular Microbiology
2010 - present Journal of Biotechnology
2010 - present FASEB J
2010 - present BioMed Central
2010 - present Microbiology
2011 - present Proceedings of the National Academy of Sciences USA
2011 - present PLoS Pathogens
2011 - present PLoS One
2011 - present Translational Research
2011 - present Journal of Bacteriology
2012 - present PLoS One
2012 - present Innate Immunity
2013 - present JOVE
2013 - present Molecular and Cellular Microbiology
2014 - present Microbial Pathogenesis
2015 - present Journal of Innate Immunity
2015 - present Journal of Infectious Diseases
2015 - present ACS Books
2015 - present Human Immunology
2015 Abstract Selection Committee 46th Union World Conference on Lung Health
 

Honors

2003 Distinction to Excellence in Research. The Ministry of Education of Spain.
2003 - 2008 Post-doctoral Fellowship, NIH-NIAID, The Ohio State University, USA. OSU-Internal Medicine.
2006 NIAID Keystone Scholarship (Innate Immunity). NIH/NIAID.
2006 James V. Warren Award as recognition of outstanding and excellence in research performed in the Department of Internal Medicine at The Ohio State University. OSU-Internal Medicine.
2007 Travel award from the Society for Glycobiology. Society for Glycobiology.
2007 The Ohio State University Medical Center Candidate elected for the 2008 Parker B. Francis Fellowship. OSU-Office of Research.
2008 - 2011 Parker B. Francis Fellowship in Pulmonary research. Parker B. Francis.
2009 The Ohio State University Candidate elected for the 2010 Pew Scholar Fellowship. OSU-Office of Research.
2010 The Ohio State University Candidate elected for the 2011 Burroughs Wellcome Fund Program. OSU-Office of Research.
2012 The Ohio State University Candidate elected for the 2013 Burroughs Wellcome Fund Program. OSU-Office of Research.
2012 Public Health Preparedness for Infectious Diseases Travel Fellowship. Public Health Preparedness for Infectious Diseases-College of Public Health, The Ohio State University.
2015 OSU Center for Clinical and Translational Sciences - Clinical Research Center Servie Support Award. OSU-CCTS.
2015 OSU College of Medicine Special Faculty Award to Recognize Outstanding Performance. OSU-COM.
 

Journal Articles

 

Inventions and Patents

Compositions and methods for treating and preventing Porcine Reproductive and Respiratory Syndrome

 

Presentations

Serovars of Mycobacterium avium complex isolated from AIDS and non-AIDS patients in Spain

Role of the lipoarabinomannan (LAM) in the pathogenicity of Tuberculosis: Importance as a target for antibiotics

Identification of glycoproteins in Mycobacterium avium

Alteration in the structure of lipoarabinomannan as a consequence of ethambutol treatment in M. tuberculosis

Defining the structure and functional characteristics of distinct isoforms of LAM from Mycobacterium tuberculosis H37Rv

Involvement of the emb genes in the arabinan biosynthesis

Defining the mechanism of the biochemical and genetic basis of ethambutol-resistance

Isoforms of Lipoarabinomannan from Mycobacterium tuberculosis that are recognized by CD1-restricted T-cells: Their potential role in mediating immune responses in human.

Isoforms of Lipoarabinomannan from Mycobacterium tuberculosis that are recognized by CD1-restricted T cells

On arabinnan biosynthesis in arabinogalactan and lipoarabinomannan: The mycobacterial cell wall polysaccharides

Characterization of Lipoarabinomannan Isoforms of Mycobacterium tuberculosis responsible for precise recognition by CD1-restricted T cells

Point Mutations in embC affect synthesis of lipoarabinomannan in Mycobacterium smegmatis

On arabinan biosynthesis of mycobacterial cell wall arabinogalactan

IThe role of Mycobacterium tuberculosis phosphomannomutases in the biosynthesis of cell wall glycoconjugates

Biochemical characterization of the cell envelope from mycobacterial strains over-expressing genes involved in mannose biosynthesis in Mycobacterium tuberculosis

The role of Mycobacterium tuberculosis phosphomannomutases in the biosynthesis of cell wall glycoconjugates

Characterization of manB, a functional Mycobacterium tuberculosis phosphomannomutase involved in the biosynthesis of surface expressed mannosylated glycoconjugates

The nature of the inflammatory response to Mycobacterium tuberculosis cell wall carbohydrates by alternatively activated macrophages

Characterization of manB, a functional Mycobacterium tuberculosis phosphomannomutase involved in the biosynthesis of surface expressed mannosylated glycoconjugates

Characterization of the association of purified phosphatidylinositol mannoside species from Mycobacterium tuberculosis with the human macrophage mannose receptor

Identification and characterization of Mycobacterium tuberculosis genes encoding phosphomannomutase/phosphoglucomutase activity

The human macrophage mannose receptor directs Mycobacterium tuberculosis manose-capped lipoarabinomannan in limiting phagosome-lysosome fusion in mammalian cells

TCharacterization of the association of purified phosphatidylinositol mannoside species from Mycobacterium tuberculosis with the human macrophage mannose receptor

Characterization of manB, a functional Mycobacterium tuberculosis phosphomannomutase involved in the biosynthesis of surface expressed mannosylated glycoconjugates

Differential activation of Nods in human macrophages by cell wall lipoarabinomannan from Mycobacterium tuberculosis and an avirulent Mycobacterium spp

Fine discrimination in the recognition of individual species of phosphatidyl-myo-inositol mannosides from Mycobacterium tuberculosis by C-type lectin pattern recognition receptors

Phosphatidyl-myo-inositol mannosides at the corner of Mycobacterium tuberculosis pathogenesis

Fine recognition of mannosylated cell wall components of Mycobacterium tuberculosis and by trimeric subunits of surfactant protein D

Fine recognition of mannosylated cell wall components of Mycobacterium tuberculosis and by trimeric subunits of surfactant protein D

Fine recognition of mannosylated cell wall components of Mycobacterium tuberculosis and by trimeric subunits of surfactant protein D

DC-SIGN cytoplasmic motifs regulate phgocytosis and phagosome-lysosome fusion events mediated by Mycobacterium tuberculosis mannose-capped lipoarabinomannan in myeloid cells

Heterogeneity of cell wall carbohydrates and lipids from clinical isolates of Mycobacterium tuberculosis dictates interactions with the human host

Differential activation of NODs in human macrophages by lipomannan and mannose-capped lipoarabinomannan from Mycobacterium tuberculosis

A genetic clone of Mycobacterium tuberculosis that has altered interactions with human macrophages and variation in ManLAM structure

Lipidomics of the Mycobacterium tuberculosis mannose-capped lipoarabinomannan phagosome in human macrophages

DC-SIGN cytoplasmic motifs regulate phgocytosis and phagosome-lysosome fusion events mediated by Mycobacterium tuberculosis mannose-capped lipoarabinomannan in myeloid cells

Heterogeneity of cell wall carbohydrates and lipids from clinical isolates of Mycobacterium tuberculosis dictates interactions with the human host

A genetic clone of Mycobacterium tuberculosis that has altered interactions with human macrophages and variation in ManLAM structure

A genetic clone of Mycobacterium tuberculosis that has altered interactions with human macrophages and variation in ManLAM structure

Recognition of Mycobacteria species and mannosylated cell wall components by collagen deletion trimeric subunits of surfactant D

C-type lectin DC-SIGN cytoplasmic motif regulates receptor activity in human myeloid cells

Heterogeneity of cell wall carbohydrates and lipids from clinical isolates of Mycobacterium tuberculosis: Impact on interactions with the human host

Deletion of the Mannosyltransferase PimB reduces surface expression of the cell wall lipoarabinomannan in Mycobacterium tuberculosis affecting the rate of macrophage cell death

Virulence factors of Mycobacterium avium complex from drinking water

Surfactant Protein D and Innate Immunity to Mycobacterium tuberculosis: Structure-function analysis of binding and regulation of bacterial uptake and survival in human macrophages

Deletion of the Mannosyltransferase PimB reduces surface expression of the cell wall lipoarabinomannan in Mycobacterium tuberculosis affecting the rate of macrophage cell death

C-type lectin DC-SIGN cytoplasmic motif regulates receptor activity in human myeloid cells

Remodeling of the Mycobacterium tuberculosis cell wall by enzymes in the lung microenvironment alter bacterial recognition and fate in human macrophages

Mycobacterium tuberculosis mannose-capped lipoarabinomannan alters the human macrophage immune response through the nuclear receptor PPAR-gamma

Surfactant Protein D and Innate Immunity to Mycobacterium tuberculosis: Structure-function analysis of binding and regulation of bacterial uptake and survival in human macrophages

Surfactant Protein D and Innate Immunity to Mycobacterium tuberculosis: Structure-function analysis of binding and regulation of bacterial uptake and survival in human macrophages

Biosynthesis of a Mycobacterium tuberculosis enzyme (PPM) that generates key mannose donors for cell envelope mannose-containing lipoglycans important in bacterial virulence

Surfactant Protein D and Innate Immunity to Mycobacterium tuberculosis: Structure-function analysis of binding and regulation of bacterial uptake and survival in human macrophages

Mycobacterium tuberculosis activation of human macrophage PPARg links to the mannose receptor in regulating immune responses

Cloning and characterization of genes involved in the biosynthetic pathway fro cell envelope mannose-containing lypoglycans in Mycobacterium tuberculosis

Remodeling of the Mycobacterium tuberculosis cell wall by enzymes in the lung microenvironment alter bacterial recognition and fate in human macrophages

Influence of Human Lung Hydrolases on Mycobacterium tuberculosis Infection

Enhanced binding of the pulmonary surfactant protein-D mutant, R343V, to Mycobacterium tuberculosis, a potential immunotherapy

Characterization of a Mycobacterium tuberculosis operon that regulates mannosylation of the mycobacterial cell wall

Effects of lung mucosal hydrolases on Mycobacterium tuberculosis pathogenesis

The metabolism of a key Mycobacterium tuberculosis cell wall lipoglycan mannose-capped lipoarabinomannan (ManLAM) in human macrophages.

Structural differences in lipomannans from pathogenic and non-pathogenic mycobacteria and their impact on CD1b-restricted T cell proliferation

Lung mucosal hydrolases and Mycobacterium tuberculosis pathogenesis

Characterization of a Mycobacterium tuberculosis operon that regulates mannosylation of the mycobacterial cell wall

Characterization of the Production of Mycobacterium tuberculosis lipoarabinomannan, lipomannan and phosphatidyl-myo-inositol mannosides during bacterial growth

Lung hydrolases alter the infection outcome of Mycobacterium tuberculosis in human macrophages

Biochemical nature of Mycobacterium tuberculosis cell wall fragments released by exposure to human lung surfactant hydrolases and their capacity to enhance the control of infection by human macrophages

Consuming Consumption: Lung mucosal hydrolases and Mycobacterium tuberculosis pathogenesis

Consuming Consumption: Lung mucosal hydrolases and Mycobacterium tuberculosis pathogenesis

Effects of the human lung environment in Mycobacterium tuberculosis pathogenesis

Characterization of a Mycobacterium tuberculosis operon that regulates mannosylation of the mycobacterial cell wall

Biochemical properties of Mycobacterium tuberculosis cell wall fragments released following exposure to human hydrolases and their impact in the capacity of controlling infection by human macrophages

The host immune response induced by Mycobacterium tuberculosis cell wall fragments released by the action of human lung surfactant hydrolases

The mannose-capped lipoarabinomannan phagosome lipid composition and its implications on the intracellular survival of Mycobacterium tuberculosis within human macrophages

Effects of Mycobacterium tuberculosis cell wall fragments released by the action of human lung hydrolases in the host immune response

Mycobacterium tuberculosis lipomannan blocks TNF biosynthesis in human macrophages by regulation of MAP kinase-activated protein kinase 2 (MK2) and mir125b

Functional characterization of PPX/GPPA enzymes of Campylobacter jejuni

Diangelo L, Arcos J, Sasindran SJ, Gadkari V, and Torrelles JB.

Human lung surfactant hydrolases alter the Mycobacterium tuberculosis cell surface influencing the human macrophage capacity to control the infection

Nanoparticle-based killed adjuvanted porcine reproductive and respiratory syndrome virus vaccine elicits superior cross-protective immunity in pigs

Lung hydrolases as a novel innate defense mechanism against M. tuberculosis infection

Effects of Mycobacterium tuberculosis Cell Wall Fragments in the Host Immune Response

Remodeling of the Mycobacterium tuberculosis cell wall by the host lung environment

Elucidation of Mycobacterium tuberculosis Rv3256c: A putative enzyme involved in the mannose donor biosynthesis pathway

Human lung surfactant hydrolases alter Mycobacterium tuberculosis-Neutrophil interactions

Growth-dependent changes in major cell wall components of Mycobacterium tuberculosis

Growth-dependent changes in major cell wall components of Mycobacterium tuberculosis

Modifications of Pseudomonas aeruginosa cell envelope in the cystic fibrosis airway alters interactions with immune cells

Who are we at OSU?

Consuming Consumption: Influence of the alveolar environment in Mycobacterium tuberculosis pathogenesis

Who are we at OSU?

Consuming Consumption: How the lung environment determines Mycobacterium tuberculosis pathogenesis

Consuming Consumption: How the lung environment determines Mycobacterium tuberculosis pathogenesis

Determination of surfactant hydrolase content activities in alveolar lining fluid obtained from cystic fibrosis patientsbronchoalveolar lavage fluid

Nanoparticle-based killed adjuvanted porcine reproductive and respiratory syndrome virus vaccine elicits superior cross-protective immunity in pigs

Nanoparticle-based killed adjuvanted porcine reproductive and respiratory syndrome virus vaccine elicits superior cross-protective immunity in pigs

Nanoparticle-based killed adjuvanted porcine reproductive and respiratory syndrome virus vaccine elicits superior cross-protective immunity in pigs

Time-dependent changes in major cell wall components of Mycobacterium tuberculosis druing in-vitro growth

Influence of human alveolar lining fluid in Mycobacterium tuberculosis-host cell recognition

The role of the lung environment in Mycobacterium tuberculosis-neutrophil interactions

Improving the Diagnosis of TB in Guatemala

Role of human alveolar lining fluid in the host immune response to Mycobacterium tuberculosis infection

Poly-phosphate (Poly-P) of Campylobacter jejuni is associated with invasion and survival in human epithelial cells

Reduced association and altered cytokine production by monocyte-derived macrophage infected with BCG

Effects of the human lung environment on Mycobaterium tuberculosis pathogenesis

Consuming Consumption: Influence fo the Alveolar Environment in Mycobacterium tuberculosis Pathogenesis

Evolving Concepts of Mycobacterium tuberculosis:  Pathophysiology, Immune Response, and Rapid Diagnostics

Improving Tuberculosis Diagnosis in the Central America Region: New tools for Point-of-Care settings

Improving Tuberculosis Diagnosis in Malawi

Lines of Tuberculosis Research at The Ohio State University

Increased protective efficacy in mice infected with hydrolase exposed Mycobacterium tuberculosis

Mycobacterium tuberculosis cell wall fragments released upon exposure to the lung environment alter neutrophils function

Human lung hydrolases: A novel innate defense mechanishm influencing Mycobacterium tuberculosis infection outcome

Glycopeptidolipids for evaluating the role of non-tuberculous mycobacteria in latent tuberculosis infection diagnosis

Human lung hydrolases: A novel innate defense mechanishm influencing Mycobacterium tuberculosis infection outcome

Contribution of outer material to Campylobacter jejuni virulence

The role of the lung environment on Mycobacterium tuberculosis-neutrophil interactions

Effects of Human alveolar environment on Mycobacterium tuberculosis-host cell recognition

Influence of human alveolar lining fluid in Mycobacterium tuberculosis-host cell recognition

Modifications of Pseudomonas aeruginosa cell envelope in the cystic fibrosis airway alters interactions with immune cells

The alveolar environment defines Mycobacterium tuberculosis-host cell interactions and the subsequent infection outcome

Elucidation of Mycobacterium tuberculosis Rv3256c: A putative enzyme involved in the mannose donor biosynthesis pathway

Elucidation of Mycobacterium tuberculosis Rv3256c: A putative enzyme involved in the mannose donor biosynthesis pathway

Lung Mucosa Alters the Mycobacterium tuberculosis Cell Envelope Modulating the Outcome of Infection in Human Macrophages

Consuming Consumption: Impact of the lung environment in Mycobacterium tuberculosis infection

Impact of the human lung mucosa on Mycobacterium tuberculosis pathogenesis

Influence of the Human Alveolar Lining Fluid on the Interaction of Mycobacterium tuberculosis with Host Cells

Effects of human alveolar environment on Mycobacterium tuberculosis-host cell recognition

Interaction of Human Neutrophils with M. tuberculosis Cell Wall Fragments Exposed to Human Lung Hydrolases

Human Alveolar Hydrolase Derived Modification on the Cell Wall of Mycobacterium tuberculosis Impact the Course of Infection in vivo

Elucidation of Mycobacterium tuberculosis Rv3256c: A putative enzyme involved in the mannose donor biosynthesis pathway

Lung Hydrolases modify the course of Mycobacterium tuberculosis infection in vivo

Influence of the human alveolar lining fluid in the host immune response to Mycobacterium tuberculosis infection

Lung Mucosa Alters the Mycobacterium tuberculosis Cell Envelope Modulating the Outcome of Infection in Human Macrophages

Structural characterization of Pseudomonas aeruginosa surface-associated Psl

Developing new point-of-care approaches for the diagnosis of tuberculosis in endemic areas of Central America

Modifications on the Mycobacterium tuberculosis cell wall surface by human lung hydrolases alters the immunological response in vivo

Lung mucosa alters the Mycobacterium tuberculosis cell envelope modulating the outcome of infection in human macrophages

In vivo effects of lung hydrolase modifications to the cell wall of Mycobacterium tuberculosis

Modifications to the peripheral lipid layer on the cell wall of Mycobacterium tuberculosis by human alveolar hydrolases amplifies its virulence in C57BL/6 mice

Impact of the Human Lung Mucosa in Mycobacterium tuberculosis Infection

Components present in human alveolar lining fluid determine the course of infection with Mycobacterium tuberculosis

Improving the Diagnosis of Tuberculosis in Guatemala (and Other Parts of the World)

Components present in human alveolar lining fluid determine the course of infection with Mycobacterium tuberculosis

Lung mucosa lining fluid modifies Mycobacterium tuberculosis to reprogram neutrophil killing mechanisms to preserve the anti-inflammatory integrity of the lung

Who are we at OSU?

How does the human lung mucosa impact Mycobacterium tuberculosis infection?

Components present in human alveolar lining fluid modify the course of infection with Mycobacterium tuberculosis in C57BL/6 mice

Consuming Consumption: Role of the human lung environment in defining the M. tuberculosis pathway of infection

Management of TB: The best international extract

 

Professional Activities

present 15th Congress of Catalan Medical Doctors and Biologists. Congress of Catalan Medical Doctors and Biologists.
present American Association for Immunologists (AAI) Annual Meeting/Tuberculosis Block. American Association for Immunologists (AAI). Pittsburg, PA.
present 8th Conference of International Federation of Science Editors (IFSE). Conference of International Federation of Science Editors (IFSE).
present 24th Meeting of the Federation of European Biochemical Societies (FEBS). Meeting of the Federation of European Biochemical Societies (FEBS).
0 Symposium on TB diagnostics in Panama. OSU PHPID and Panamanian HIV National Program.
2012 Symposium on TB diagnostics in Guatemala. AIDS & Society Foundation and OSU PHPID.
 

Unpublished Works

Human lung mucosa generates Mycobacterium tuberculosis cell envelope fragments that modulate the outcome of infection in macrophages

Lipidomics of Mycobacterium tuberculosis by MALDI-Imaging thin-layer-chromatography

The Host environment influence on the Mycobacterium tuberculosis cell envelope

Elucidation of Mycobacterium tuberculosis Rv3256c: a putative enzyme involved in the mannose donor biosynthesis pathway

Why does the Bacille de Calmette et Guérin (BCG) fail to confer sterilizing immunity to tuberculosis?

Campylobacter jejuni polyphosphate kinases shape the bacterial outer material composition influencing invasion and survival in human epithelial cells

A chemoproteomic screen sequentially identifies fatty acid synthase (FASN) as a HIV-1 host dependency factor and a new FASN inhibitor that attenuates HIV-1 replication

Impact of the human lung mucosa in the control of Mycobacterium tuberculosis infection by alveolar epithelial cells

Interaction of human neutrophils with lung mucosa exposed Mycobacterium tuberculosis cell wall released fragments

Production and characterization of porcine reproductive and respiratory syndrome virus-like-particles and evaluation of their immunogenicity in pigs

Modifications of Pseudomonas aeruginosa cell envelope by the cystic fibrosis airway alter interactions with immune cells

PLGA nanoparticle-entrapped conserved H1N1 influenza virus peptides vaccine induces peptide specific T cell response in pigs