460 W 12th Ave
Columbus, OH 43210
Phone: (614) 292-6036
Email: gunn.43@osu.edu
Current OSU Appointments
Professor, SBS-Microbial Infectn/Immunity
Professor, Microbiology Admin
Professor, Internal Medicine
Vice Chair, SBS-Microbial Infectn/Immunity
Biographical
Our Salmonella research relates to: (1) in vivo induced LPS modifications and their effect on bacterial innate immune resistance and bacterial/LPS recognition by the host, (2) the establishment and maintenance of the asymptomatic carriage state of Salmonella spp. in the human gallbladder. Our Francisella work is focused on understanding regulatory factors important to virulence gene induction, intramacrophage survival and virulence. In addition, we are interested in the biology and role in virulence of the four Francisella acid phosphatases. Regarding both Salmonella and Francisella spp, we are investigating new live, attenuated vaccines and small molecule therapeutics to advance treatment/prevention of disease.
Academic Advising
| Shipan Dai The Ohio State University. | |
| Shipan Dai The Ohio State University. | |
| Shipan Dai The Ohio State University. | |
| Shipan Dai The Ohio State University. Graduated 1998. | |
| Shipan Dai The Ohio State University. | |
| Shipan Dai The Ohio State University. | |
| Shipan Dai The Ohio State University. Graduated 2000. | |
| Shipan Dai The Ohio State University. | |
| Shipan Dai The Ohio State University. Graduated 1999. | |
| Shipan Dai The Ohio State University. | |
| Shipan Dai The Ohio State University. | |
| Shipan Dai The Ohio State University. | |
| Shipan Dai The Ohio State University. | |
| Shipan Dai The Ohio State University. Graduated 2004. | |
| Shipan Dai The Ohio State University. | |
| Shipan Dai The Ohio State University. | |
| Shipan Dai The Ohio State University. Graduated 2003. | |
| Shipan Dai The Ohio State University. Graduated 2002. | |
| Shipan Dai The Ohio State University. | |
| Shipan Dai The Ohio State University. | |
| Shipan Dai The Ohio State University. Graduated 2002. | |
| Shipan Dai The Ohio State University. | |
| Shipan Dai The Ohio State University. | |
| Shipan Dai The Ohio State University. Graduated 2000. | |
| Shipan Dai The Ohio State University. Graduated 1999. | |
| 2004 - present | Shipan Dai The Ohio State University. |
| 2007 - present | Shipan Dai The Ohio State University. |
| 2010 - present | Shipan Dai University of Texas Health Science Center at San Antonio. Graduated 2004. |
| 2010 - present | Shipan Dai University of Texas Health Science Center at San Antonio. |
| 2010 - present | Shipan Dai University of Texas Health Science Center at San Antonio. Graduated 2003. |
| 2010 - present | Shipan Dai University of Texas Health Science Center at San Antonio. Graduated 2004. |
| 2010 - present | Shipan Dai University of Texas Health Science Center at San Antonio. Graduated 2001. |
| 2011 - present | Shipan Dai The Ohio State University. |
| 2011 - present | Shipan Dai The Ohio State University. |
| 2011 - present | Shipan Dai The Ohio State University. |
| 2011 - present | Shipan Dai The Ohio State University. |
| 2011 - present | Shipan Dai The Ohio State University. |
| 2011 - present | Shipan Dai The Ohio State University. |
| 2005 - 2007 | Shipan Dai The Ohio State University. Graduated 2007. |
Chapters in Books
Gunn, J.S. and D.C. Stein. "Genetic characterization of Neisserial restriction/modification systems.." In Neisseriae, proceedings of the seventh international pathogenic neisseria conference.. Edited by M. Achtman, P. Kohl, C. Marchal, G. morelli, A. Seiter and B. Thiesen. 523-526. Berlin, Germany: Walter de Gruyter, January 1990.
Tamayo, R., A.C. Portillo, and J.S. Gunn. "Mechanisms of bacterial resistance to antimicrobial peptides." In Mammalian Host Defence Peptides. Edited by D.A. Dvine, R.E.W. Hancock. 323-348. Cambridge Univ. Press, January 2004.
Gunn, J.S. and R.K. Ernst. "The Structure and Function of Francisella LPS." In Francisella tularensis: A Biodefense concern in the third millennium. Edited by Y. Abu-Kweik, D.W. Metzger, F. Nano, A. Sjostedt, and R. Titball. -. New York: Ann NY Acad. of Sci, January 2007.
Crawford, R.W. and Gunn, J.S. "The Interaction of Bile Salts with Pathogenic and Non-Pathogenic Intestinal Bacteria." In Foodborne Microbes: Shaping the Host Ecosystem. Edited by H. Wang and L.S. Schlesinger. -. New York: ASM Press, January 2008.
Bullard B. and J.S. Gunn. "Salmonella Resistance and Response to Bile: A Key in vivo Signal." In Molecular Biology and Molecular Epidemiology of Salmonella Infections. Edited by J.J. Calva and E. Calva. -. Kerala, IN|IND: Research Signpost, January 2008.
Crawford, R.W., G. Gonzalez-Escobedo and J.S. Gunn. "Salmonella Biofilms: From Food to Human Disease,." In In Salmonella enterica: From Genome to Function. -. Norwich: Horizon Scientific Press, January 2010.
Richards, S. M., K. L. Strandberg, and J. S. Gunn. "Salmonella Regulated Lipopolysaccharide Modifications." In Subcellular Biochemistry, Endotoxins: Structure, function and recognition. Edited by X. Wang and P. Quinn. -. New York: Springer, January 2010.
Crawford, R.W., G. Gonzalez-Escobedo and J.S. Gunn. "Salmonella Biofilms: From Food to Human Disease." In Salmonella enterica: Genomics and Molecular Biology. Edited by S. Porwollik. -. Norwich: Horizon Scientific Press, January 2010.
Mohapatra N. P., S. Dai, and J. S. Gunn. "Francisella tularensis: Regulation of gene expression, intracellular trafficking and subversion of host defenses.." In Regulation of Bacterial Virulence. -. Washington, D.C: ASM Press, January 2011.
Degrees
| 1988 | B.S., Ohio State University, The |
| 1993 | Ph.D., Ohio State University, The |
Honors
| 2007 - 0 | Keynote Speaker, 16th Annual Philadelphia Infection and Immunity Forum. |
| 2009 - 0 | Nominated for John T. and Ruth Weimer Mount Award, Sphinx and Mortar Board Honorary. |
| 2009 - 0 | Journal of Bacteriology Editorial Board. |
| 2009 - 0 | Associate Editor, Frontiers in Cellular and Infection Microbiology. |
| 2009 - 0 | Nominated: OSU Alumni Award for Distinguished Teaching. |
| 2009 - 0 | Nominated: Distinguished Undergraduate Research Mentor of the Year. |
| 1987 - 1988 | BGSU Undergraduate Research Award. |
| 1987 - 1988 | James D. Graham Scholarship (Outstanding Student in Molecular Biology). |
| 1987 - 1988 | Phi Beta Kappa. |
| 1991 | Andrew J. Moyer Award (Outstanding Microbiology Graduate Student). |
| 1993 - 1995 | Microbial Pathogenesis Training Grant Recipient. |
| 2002 | Nominated for Dean's Award for Exceptional Teaching. |
| 2004 | Tzagournis Medical Research Fund Award. |
| 2009 - 2010 | OSU Beckman Scholars Grant: 1 of 3 Biomedical Science Mentors. |
Journal Articles
Woodruff, R.C., J.N. Thompson Jr., A.A. Szekely and J.S. Gunn. "Characterization of Drosophila lines for transposable elements by Southern Blot analysis with biotinylated-DNA probes." Drosophila Information Service. Vol. 66, (January 1987.): 171-177.
Gunn, J, S; Woodruff, R, C; Ludwiczak, R L. "The effect of temperature on the movement of P DNA elements in somatic tissues of Drosophila melanogaster.." Mutation research. Vol. 226, no. 4. (January 1989.): 267-72.
Gunn, J, S; Piekarowicz, A; Chien, R; Stein, D C. "Cloning and linkage analysis of Neisseria gonorrhoeae DNA methyltransferases.." Journal of bacteriology. Vol. 174, no. 17. (January 1992.): 5654-60.
Gunn, J, S; Stein, D C. "Natural variation of the NgoII restriction-modification system of Neisseria gonorrhoeae.." Gene. Vol. 132, no. 1. (January 1993.): 15-20.
Gunn, J, S; Alpuche-Aranda, C, M; Loomis, W, P; Belden, W, J; Miller, S I. "Characterization of the Salmonella typhimurium pagC/pagD chromosomal region.." Journal of bacteriology. Vol. 177, no. 17. (January 1995.): 5040-7.
Stein, D, C; Gunn, J, S; Radlinska, M; Piekarowicz, A. "Restriction and modification systems of Neisseria gonorrhoeae.." Gene. Vol. 157, no. 1-2. (January 1995.): 19-22.
Gunn, J, S; Stein, D C. "Use of a non-selective transformation technique to construct a multiply restriction/modification-deficient mutant of Neisseria gonorrhoeae.." Molecular & general genetics : MGG. Vol. 251, no. 5. (January 1996.): 509-17.
Gunn, J, S; Miller, S I. "PhoP-PhoQ activates transcription of pmrAB, encoding a two-component regulatory system involved in Salmonella typhimurium antimicrobial peptide resistance.." Journal of bacteriology. Vol. 178, no. 23. (January 1996.): 6857-64.
Gunn, J, S; Hohmann, E, L; Miller, S I. "Transcriptional regulation of Salmonella virulence: a PhoQ periplasmic domain mutation results in increased net phosphotransfer to PhoP.." Journal of bacteriology. Vol. 178, no. 21. (January 1996.): 6369-73.
Guo, L; Lim, K, B; Gunn, J, S; Bainbridge, B; Darveau, R, P; Hackett, M; Miller, S I. "Regulation of lipid A modifications by Salmonella typhimurium virulence genes phoP-phoQ.." Science (New York, N.Y.). Vol. 276, no. 5310. (January 1997.): 250-3.
Gunn, J, S; Stein, D C. "The Neisseria gonorrhoeae S.NgoVIII restriction/modification system: a type IIs system homologous to the Haemophilus parahaemolyticus HphI restriction/modification system.." Nucleic acids research. Vol. 25, no. 20. (January 1997.): 4147-52.
Guo, L; Lim, K, B; Poduje, C, M; Daniel, M; Gunn, J, S; Hackett, M; Miller, S I. "Lipid A acylation and bacterial resistance against vertebrate antimicrobial peptides.." Cell. Vol. 95, no. 2. (January 1998.): 189-98.
Gunn, J, S; Lim, K, B; Krueger, J; Kim, K; Guo, L; Hackett, M; Miller, S I. "PmrA-PmrB-regulated genes necessary for 4-aminoarabinose lipid A modification and polymyxin resistance.." Molecular microbiology. Vol. 27, no. 6. (January 1998.): 1171-82.
Gunn, J, S; Belden, W, J; Miller, S I. "Identification of PhoP-PhoQ activated genes within a duplicated region of the Salmonella typhimurium chromosome.." Microbial pathogenesis. Vol. 25, no. 2. (January 1998.): 77-90.
Stein, D, C; Gunn, J, S; Piekarowicz, A. "Sequence similarities between the genes encoding the S.NgoI and HaeII restriction/modification systems.." Biological chemistry. Vol. 379, no. 4-5. (January 1998.): 575-8.
van Velkinburgh, J, C; Gunn, J S. "PhoP-PhoQ-regulated loci are required for enhanced bile resistance in Salmonella spp.." Infection and immunity. Vol. 67, no. 4. (January 1999.): 1614-22.
Yethon, J, A; Gunn, J, S; Ernst, R, K; Miller, S, I; Laroche, L; Malo, D; Whitfield, C. "Salmonella enterica serovar typhimurium waaP mutants show increased susceptibility to polymyxin and loss of virulence In vivo.." Infection and immunity. Vol. 68, no. 8. (January 2000.): 4485-91.
Prouty, A, M; Gunn, J S. "Salmonella enterica serovar typhimurium invasion is repressed in the presence of bile.." Infection and immunity. Vol. 68, no. 12. (January 2000.): 6763-9.
Gunn, J, S; Ryan, S, S; Van Velkinburgh, J, C; Ernst, R, K; Miller, S I. "Genetic and functional analysis of a PmrA-PmrB-regulated locus necessary for lipopolysaccharide modification, antimicrobial peptide resistance, and oral virulence of Salmonella enterica serovar typhimurium.." Infection and immunity. Vol. 68, no. 11. (January 2000.): 6139-46.
Gunn, J, S; Ernst, R, K; McCoy, A, J; Miller, S I. "Constitutive mutations of the Salmonella enterica serovar Typhimurium transcriptional virulence regulator phoP.." Infection and immunity. Vol. 68, no. 6. (January 2000.): 3758-62.
Gunn, J S. "Mechanisms of bacterial resistance and response to bile.." Microbes and infection / Institut Pasteur. Vol. 2, no. 8. (January 2000.): 907-13.
McCoy, A, J; Liu, H; Falla, T, J; Gunn, J S. "Identification of Proteus mirabilis mutants with increased sensitivity to antimicrobial peptides.." Antimicrobial agents and chemotherapy. Vol. 45, no. 7. (January 2001.): 2030-7.
Gunn, J S. "Bacterial modification of LPS and resistance to antimicrobial peptides.." Journal of endotoxin research. Vol. 7, no. 1. (January 2001.): 57-62.
Dr John Spencer Gunn. "Typhoid Mary's gallstones to blame." Nature Science Update. (May 2001.): -.
Tamayo, Rita; Ryan, Sara, S; McCoy, Andrea, J; Gunn, John S. "Identification and genetic characterization of PmrA-regulated genes and genes involved in polymyxin B resistance in Salmonella enterica serovar typhimurium.." Infection and immunity. Vol. 70, no. 12. (January 2002.): 6770-8.
Prouty, Angela, M; Van Velkinburgh, Jennifer, C; Gunn, John S. "Salmonella enterica serovar typhimurium resistance to bile: identification and characterization of the tolQRA cluster.." Journal of bacteriology. Vol. 184, no. 5. (January 2002.): 1270-6.
Prouty, A, M; Schwesinger, W, H; Gunn, J S. "Biofilm formation and interaction with the surfaces of gallstones by Salmonella spp.." Infection and immunity. Vol. 70, no. 5. (January 2002.): 2640-9.
Prouty, A, M; Gunn, J S. "Comparative analysis of Salmonella enterica serovar Typhimurium biofilm formation on gallstones and on glass.." Infection and immunity. Vol. 71, no. 12. (January 2003.): 7154-8.
Vinogradov, Evgeny; Conlan, Wayne, J; Gunn, John, S; Perry, Malcolm B. "Characterization of the lipopolysaccharide O-antigen of Francisella novicida (U112).." Carbohydrate research. Vol. 339, no. 3. (January 2004.): 649-54.
Prouty, A, M; Brodsky, I, E; Manos, J; Belas, R; Falkow, S; Gunn, J S. "Transcriptional regulation of Salmonella enterica serovar Typhimurium genes by bile.." FEMS immunology and medical microbiology. Vol. 41, no. 2. (January 2004.): 177-85.
Prouty, A, M; Brodsky, I, E; Falkow, S; Gunn, J S. "Bile-salt-mediated induction of antimicrobial and bile resistance in Salmonella typhimurium.." Microbiology (Reading, England). Vol. 150, no. Pt 4. (January 2004.): 775-83.
Maier, R, J; Olczak, A; Maier, S; Soni, S; Gunn, J. "Respiratory hydrogen use by Salmonella enterica serovar Typhimurium is essential for virulence.." Infection and immunity. Vol. 72, no. 11. (January 2004.): 6294-9.
Dr John Spencer Gunn. "Antibiotic resistance and bile." Microbiology Today. Vol. 31, (January 2004.): 94-.
Brodsky, Igor, E; Gunn, John S. "A bacterial sensory system that activates resistance to innate immune defenses: potential targets for antimicrobial therapeutics.." Molecular interventions. Vol. 5, no. 6. (January 2005.): 335-7.
Tamayo, Rita; Prouty, Angela, M; Gunn, John S. "Identification and functional analysis of Salmonella enterica serovar Typhimurium PmrA-regulated genes.." FEMS immunology and medical microbiology. Vol. 43, no. 2. (January 2005.): 249-58.
Tamayo, R; Choudhury, B; Septer, A; Merighi, M; Carlson, R; Gunn, J S. "Identification of cptA, a PmrA-regulated locus required for phosphoethanolamine modification of the Salmonella enterica serovar typhimurium lipopolysaccharide core.." Journal of bacteriology. Vol. 187, no. 10. (January 2005.): 3391-9.
Navarre, William Wiley; Halsey, Thomas, A; Walthers, Don; Frye, Jonathan; McClelland, Michael; Potter, Jennifer, L; Kenney, Linda, J; Gunn, John, S; Fang, Ferric, C; Libby, Stephen J. "Co-regulation of Salmonella enterica genes required for virulence and resistance to antimicrobial peptides by SlyA and PhoP/PhoQ.." Molecular microbiology. Vol. 56, no. 2. (January 2005.): 492-508.
Merighi, Massimo; Ellermeier, Craig, D; Slauch, James, M; Gunn, John S. "Resolvase-in vivo expression technology analysis of the Salmonella enterica serovar Typhimurium PhoP and PmrA regulons in BALB/c mice.." Journal of bacteriology. Vol. 187, no. 21. (January 2005.): 7407-16.
Rajaram, Murugesan V, S; Ganesan, Latha, P; Parsa, Kishore V, L; Butchar, Jonathan, P; Gunn, John, S; Tridandapani, Susheela. "Akt/Protein kinase B modulates macrophage inflammatory response to Francisella infection and confers a survival advantage in mice.." Journal of immunology (Baltimore, Md. : 1950). Vol. 177, no. 9. (January 2006.): -.
Rajaram, M.V.S., Ganesan, L.P., Parsa, K.V.L., Butchar, J.P., Gunn, J.S., and S. Tridandapani. "Akt/PKB modulates macrophage inflammatory response to Fransicella infection and confers a survival advantage in mice." J. Immunol.. Vol. 177, (January 2006.): 6317-6324.
Gavrilin, Mikhail, A; Bouakl, Imad, J; Knatz, Nina, L; Duncan, Michelle, D; Hall, Mark, W; Gunn, John, S; Wewers, Mark D. "Internalization and phagosome escape required for Francisella to induce human monocyte IL-1beta processing and release.." Proceedings of the National Academy of Sciences of the United States of America. Vol. 103, no. 1. (January 2006.): 141-6.
Ban Nasr, A., J. Haithcoat, J.E. Masterson, J.S. Gunn, T. Eaves-Pyles, and G.R. Klimpel.. "Critical role for serum opsonins and complement receptors CR3 (CD11b/CD18) and CR4 (CD11c/CD18) in phagocytosis of Francisella tularensis by human dendritic cells (DC): Uptake of Francisella leads to activation of immature DCs and intracellular survival of the bacteria." J. Lek. Biol.. Vol. 80, (January 2006.): 774-86.
Balagopal, Ashwin; MacFarlane, Amanda Shearer; Mohapatra, Nrusingh; Soni, Shilpa; Gunn, John, S; Schlesinger, Larry S. "Characterization of the receptor-ligand pathways important for entry and survival of Francisella tularensis in human macrophages.." Infection and immunity. Vol. 74, no. 9. (January 2006.): 5114-25.
Parsa, Kishore V, L; Ganesan, Latha, P; Rajaram, Murugesan V, S; Gavrilin, Mikhail, A; Balagopal, Ashwin; Mohapatra, Nrusingh, P; Wewers, Mark, D; Schlesinger, Larry, S; Gunn, John, S; Tridandapani, Susheela. "Macrophage pro-inflammatory response to Francisella novicida infection is regulated by SHIP.." PLoS pathogens. Vol. 2, no. 7. (January 2006.): e71-.
Merighi, Massimo; Carroll-Portillo, Amanda; Septer, Alecia, N; Bhatiya, Aditi; Gunn, John S. "Role of Salmonella enterica serovar Typhimurium two-component system PreA/PreB in modulating PmrA-regulated gene transcription.." Journal of bacteriology. Vol. 188, no. 1. (January 2006.): 141-9.
Gunn, John, S; Richards, Susan M. "Recognition and integration of multiple environmental signals by the bacterial sensor kinase PhoQ.." Cell host & microbe. Vol. 1, no. 3. (January 2007.): -.
Mohaptara, N., A. Balagopal, L.S. Schlesinger, and J.S. Gunn. "AcpA, an Acid Phosphatase involved in Francisella tularensis Virulence." Infection and Immunity. Vol. 75, (January 2007.): 390-396.
Mohapatra, Nrusingh, P; Soni, Shilpa; Bell, Brian, L; Warren, Richard; Ernst, Robert, K; Muszynski, Artur; Carlson, Russell, W; Gunn, John S. "Identification of an orphan response regulator required for the virulence of Francisella spp. and transcription of pathogenicity island genes.." Infection and immunity. Vol. 75, no. 7. (January 2007.): -.
Mohapatra, Nrusingh, P; Balagopal, Ashwin; Soni, Shilpa; Schlesinger, Larry, S; Gunn, John S. "AcpA is a Francisella acid phosphatase that affects intramacrophage survival and virulence.." Infection and immunity. Vol. 75, no. 1. (January 2007.): -.
Mohapatra, N.P., S. Soni, B.L. Bell, R. Warren, R.K. Ernst, A. Muszynski, R. Carlson, and J.S. Gunn. "Identification of an orphan response regulator required for Francisella virulence and transcription of pathogenicity island genes.." Infection and Immunity. no. 75. (January 2007.): 3305-3314.
Pastelin-Palacios, R; RamÃrez-Saldaña, M; Gunn, JS; Acosta-RamÃrez, E; Cervantes-Barragán, L; Gil-Cruz, C; Isibasi, A; López-MacÃas, C. "Salmonella typhimurium down-regulates the host innate immune response by inducing lipopolysaccharide lipid A structural modifications.." Proceedings of the 13th International Congress of Immunology - ICI. (January 2007.): -.
Clay, C.D., S. Soni, J.S. Gunn and L.S. Schlesinger. "Evasion of complement-mediated lysis and complement C3 deposition are regulated by Francisella tularensis LPS O-antigen.." Journal of Immunology. no. 181. (January 2008.): 5568-5578.
Mohapatra NP; Soni S; Reilly TJ; Liu J; Klose KE; Gunn JS. "Combined deletion of four Francisella novicida acid phosphatases attenuates virulence and macrophage vacuolar escape.." Infection And Immunity. Vol. 76, no. 8. (August 2008.): 3690-.
Crawford RW; Gibson DL; Kay WW; Gunn JS. "Identification of a bile-induced exopolysaccharide required for Salmonella biofilm formation on gallstone surfaces.." Infection And Immunity. Vol. 76, no. 11. (November 2008.): 5341-.
Bestley S; Patterson TA; Hindell MA; Gunn JS. "Feeding ecology of wild migratory tunas revealed by archival tag records of visceral warming.." The Journal Of Animal Ecology. Vol. 77, no. 6. (November 2008.): 1223-.
Woo H; Okamoto S; Guiney D; Gunn JS; Fierer J. "A model of Salmonella colitis with features of diarrhea in SLC11A1 wild-type mice.." Plos ONE. Vol. 3, no. 2. (January 2008.): e1603-.
Pechous, R.D., T.R. McCarthy, N.P. Mohapatra, S. Soni, R.M. Penoske, N.H. Salzman, D.W. Frank, J.S. Gunn, and T.C. Zahrt. "Vaccination with ?purMCD mutants of Schu S4 and LVS protects against respiratory challenge with virulent type A and type B F. tularensis." PLOS One. no. 3. (January 2008.): e2487-.
Pechous RD; McCarthy TR; Mohapatra NP; Soni S; Penoske RM; Salzman NH; Frank DW; Gunn JS; Zahrt TC. "A Francisella tularensis Schu S4 purine auxotroph is highly attenuated in mice but offers limited protection against homologous intranasal challenge.." Plos ONE. Vol. 3, no. 6. (January 2008.): e2487-.
Gunn JS. "The Salmonella PmrAB regulon: lipopolysaccharide modifications, antimicrobial peptide resistance and more.." Trends In Microbiology. Vol. 16, no. 6. (June 2008.): 284-.
Roth KM; Oghumu S; Satoskar AA; Gunn JS; van Rooijen N; Satoskar AR. "Respiratory infection with Francisella novicida induces rapid dystrophic cardiac calcinosis (DCC).." FEMS Immunology And Medical Microbiology. Vol. 53, no. 1. (June 2008.): 72-.
Parsa KV; Butchar JP; Rajaram MV; Cremer TJ; Gunn JS; Schlesinger LS; Tridandapani S. "Francisella gains a survival advantage within mononuclear phagocytes by suppressing the host IFNgamma response.." Molecular Immunology. Vol. 45, no. 12. (July 2008.): 3428-.
Roth KM; Gunn JS; Lafuse W; Satoskar AR. "Francisella inhibits STAT1-mediated signaling in macrophages and prevents activation of antigen-specific T cells.." International Immunology. Vol. 21, no. 1. (January 2008.): 19-.
Cremer, T. J., D. H. Ravneberg, C. D. Clay, M. G. Piper-Hunter, C. B.Marsh, T. S. Elton, J. S. Gunn, A. Amer, T. D. Kanneganti, L. S. Schlesinger, J. P. Butchar, and S. Tridandapani.. "MiR-155 induction by F. novicida but not the more virulent F. tularensis, results in SHIP downregulation and enhanced proinflammatory cytokine response.." PLoS One. Vol. 4, no. 12. (January 2009.): e8508-.
) Roth KM, JS Gunn, W Lafuse, AR Satoskar. "Francisella inhibits STAT1-mediated signaling in macrophages and prevents activation of antigen-specific T cells." Int Immunol.. no. 21(1):19-28. PMID: 19001470. (January 2009.): -.
McRae, S.F. Pagliai, N. P. Mohapatra, A. Gener, A. S. Abdelgeliel Mahmou, J. S. Gunn, G. L. Lorca, and C. F. Gonzalez. "Inhibition of AcpA phosphatase activity with ascorbate attenuated Francisella tularensis intramacrophage survival." J. Biol. Chem. no. 285(8). (January 2009.): 5171-5177.
McRae S, Pagliai FA, Mohapatra NP, Gener A, Abdelgeliel Mahmou AS, Gunn JS,Lorca GL, Gonzalez CF. "Inhibition of AcpA phosphatase activity with ascorbateattenuates Francisella tularensis intramacrophage survival." J Biol Chem.. no. Epub ahead of print. (January 2009.): -.
Chiu, HC, S. Soni, S.K. Kulp, H. Curry, D.Wang, J.S. Gunn, L.S. Schlesinger and C.S. Chen. "Eradication of intracellular Francisella tularensis in THP-1 human macrophages with a novel autophagy inducing agent." J. Biomed. Sci.. Vol. 110, no. 16. (January 2009.): -.
Chiu, HC, S. Soni, S.K. Kulp, H. Curry, D.Wang, J.S. Gunn, L.S. Schlesinger and C.S. Chen. "Eradication of intracellular Francisella tularensis in THP-1 human macrophages with a novel autophagy inducing agent." J. Biomed. Sci. no. 16:110. (January 2009.): -.
Chiu, H.C., J.Yang, S. Soni, S.K. Kulp, J.S. Gunn, L.S. Schlesinger, C.S. Chen. "Pharmacological Exploitation of an Off-Target Antibacterial Effect of the Cyclooxygenase-2 Inhibitor Celecoxib against Francisella tularensis.." Antimicrob. Agents Chemother. Vol. 53, (January 2009.): 2998-3002.
Chiu HC, SK Kulp, S. Soni, D. Wang, J.S. Gunn, L.S. Schlesinger and C.S. Chen. "Eradication of intracellular Salmonella enterica serovar Typhimurium with a small-molecule, host cell-directed agent." Antimicrob Agents Chemother. no. 53. (January 2009.): 5236-5244.
Roth KM, JS Gunn, W Lafuse, AR Satoskar. F. "Francisella inhibits STAT1-mediated signaling in macrophages and prevents activation of antigen-specific T cells." Int Immunol.. no. 21(1). (January 2009.): 19-28.
Olakanmi, O., J. S. Gunn, S. Su, S. Soni, D. J. Hassett, and B. E. Britigan. "Gallium Disrupts Iron Uptake By Intracellular And Extracellular Francisella And Exhibits Therapeutic Efficacy In A Murine Pulmonary Infection Model." Antimicrob. Agents and Chemother.. Vol. 54(1):, (January 2009.): 244-253.
Merighi, M., A.N. Septer, A.M. Carroll-Portillo, A. Bhatiya, S. Porwollik, M. McClelland and J.S. Gunn. "Genome-wide analysis of the PreA/PreB (QseB/QseC) regulon of Salmonella typhimurium.." BMC Microbiology. (January 2009.): -.
Soni S., R.K. Ernst, A. Muszynski, N. P. Mohapatra, M. B. Perry, E.Vinogradov, R. Carlson, J.S. Gunn.. "Francisella tularensis blue-gray phase variation involves structural modifications of lipopolysaccharide O-antigen, core and lipid A and affects intramacrophage survival and vaccine efficacy." Front. Microbio.. no. 1:129. (January 2010.): -.
Cremer, T. J., D. H. Ravneberg, C. D. Clay, M. G. Piper-Hunter, C. B.Marsh, T. S. Elton, J. S. Gunn, A. Amer, T. D. Kanneganti, L. S. Schlesinger, J. P. Butchar, and S. Tridandapani. "MiR-155 induction by F. novicida but not the more virulent F. tularensis, results in SHIP downregulation and enhanced proinflammatory cytokine response." PLoS One. no. e8508. (January 2010.): -.
Crawford, R.W., R. Rosales-Reyes, M. RamÃrez-Aguilar, O. Chapa-Azuela, C. Alpuche-Aranda and J.S. Gunn. "Gallstones play a significant role in Salmonella spp. gallbladder colonization and carriage." PNAS. no. 107(9):4353-8. (January 2010.): -.
Crawford R.W., K.E. Reeve and J.S. Gunn. "Flagellated but not hyperfimbriated Salmonella enterica serovar Typhimurium attach to and form biofilms on cholesterol-coated surfaces.." J. Bacteriol.. no. 192(12). (January 2010.): 2981-2990.
Bell, B. L., N. P. Mohapatra and J. S. Gunn.. "Regulation of Virulence Gene Transcripts by the Francisella Orphan Response Regulator PmrA: Role of Phosphorylation and Evidence of MglA/SspA interaction." Infect. Immun. no. 78(5):2189-98. PMID: 20231408. (January 2010.): -.
Bell, B. L., N. P. Mohapatra and J. S. Gunn. "Regulation of Virulence Gene Transcripts by the Francisella Orphan Response Regulator PmrA: Role of Phosphorylation and Evidence of MglA/SspA interaction.." Infect. Immun. no. 78(5). (January 2010.): 2189-2198.
Mohapatra, N.P., S. Soni, R. Murugesan, M.C. Dang, J. El benna, L.S. Schlesinger, J.S. Gunn.. "Francisella acid phosphatases inactivate the NADPH oxidase in human phagocytes." J. Immunol. no. 184(9). (January 2010.): 5141-5150.
Mohapatra, N.P., S. Soni, R. Murugesan, M.C. Dang, J. El benna, L.S. Schlesinger, J.S. Gunn.. "Francisella acid phosphatases dephosphorylate and inactivate host NADPH oxidase complex components in human phagocytes.." J. Immunol.. no. 184(9):5141-50. PMID: 20348422. (January 2010.): -.
McRae, S.F. Pagliai, N. P. Mohapatra, A. Gener, A. S. Abdelgeliel Mahmou, J. S. Gunn, G. L. Lorca, and C. F. Gonzalez. "Inhibition of AcpA phosphatase activity with ascorbate attenuated Francisella tularensis intramacrophage survival." J. Biol. Chem. no. 285(8):5171-7 PMID: 20028980. (January 2010.): -.
Kim, B, S.M. Richards, J. S. Gunn, and J.M. Slauch. "Protecting from antimicrobial effectors in the phagosome allows SodCII to contribute to virulence in Salmonella enterica serovar Typhimurium." J. Bacteriol.. no. 192(8):2140-9. PMID: 20154132. (January 2010.): -.
Pastelin-Palacios, R., C. Gil-Cruz, C. Perez-Shibayama, M. Moreno-Eutimio, L. Cervantes-Barragan, L. Arriaga-Pizano, B. Ludewig, A. Cunningham, E. Garcia Zepeda, I. Becker, C. Alpuche-Aranda, L. Bonifaz, J.S. Gunn, A. Isibasi, and C. Lopez-Macias.. "Subversion of Innate and Adaptive Immune Activation induced by structurally modified LPS from Salmonella typhimurium." Immunology. Vol. 133, no. 4. (August 2011.): 469-481.
Reference Works
| January 1998 | J.S. Gunn."PmrA-PmrB regulated modifcation of LPS" Santa Fe, NM. |
| January 1998 | J.C. VanVelkinburgh and J.S. Gunn."Characterization of PhoP-and PmrA regulated gene promoters" Atlanta, GA. |
| January 1998 | R. Tekulve, R. Edwards, P. Smith, J. Gunn, S. Miller, E. Groisman and M. Spector."Genetic characterization of starvation-inducible resistance to the antimicrobial peptide polymyxin in Salmonella Typhimurium" . |
| January 1999 | J.S. Gunn, J.C. Van Velkinburgh, and A.M. Lang."Identification of salmonella loci necessary for resistance to bile" . |
| January 1999 | Dr John Spencer Gunn."" Texas Branch ASM, Fort Worth, TX. |
| January 1999 | Dr John Spencer Gunn."Characterization of Proteus mirabilis and Burkholderia cepacia Mechanisms of Resistance to IB-367" Mountain View, CA. |
| January 1999 | Dr John Spencer Gunn."Salmonella’s interactions with bile: Mechanisms of resistance and effect on invasion of epithelial cells" Texas Branch ASM, Fort Worth, TX. |
| January 1999 | A.M. Lang, J.C. Van Velkinburgh, J.S. Gunn."Identification of salmonella loci necessary for resistance to bile" Fort Worth, Texas. |
| January 1999 | S.S. Ryan and J.S. Gunn."Characterization of the PmrA-PmrB Regulon in Salmonella typhimurium" . |
| January 2000 | Dr John Spencer Gunn."The Role of The PhoPQ/PmrAB Two-Component Regulatory Cascade in Salmonella virulence" San Antonio, TX. |
| January 2000 | Dr John Spencer Gunn."Co-Convener of Tissue-Specific Expression of Virulence Genes Session" Los Angeles, CA. |
| January 2000 | Dr John Spencer Gunn."Resistance of Salmonella to Intestinal Antimicrobials" Los Angeles, CA. |
| January 2000 | A.M. Lang and J.S. Gunn."Salmonella typhirmurium invasion is repressed in the presence of bile" Corpus Christi, Texas. |
| January 2000 | A.M. Lang and J.S. Gunn."Salmonella typhimurium invasion is repressed in the presence of bile" Los Angeles, California. |
| January 2000 | A.J. McCoy, J.S. Gunn, H. Liu, and T.J. Falla."Identification and characterization of Proteus mirabilis mutant sensitive to antimicrobial peptides" Los Angeles, California. |
| January 2001 | A.M. Prouty and J.S. Gunn."The formation of biofilms on gallstones by Salmonella spp" San Antonio, Texas. |
| January 2001 | A.M. Prouty and J.S. Gunn."The formation of biofilms on gallstones by Salmonella spp" Orlando, Florida. |
| January 2001 | A. Carroll and J.S. Gunn."Identification and characterization of a novel two-component regulatory system in Salmonella typhimurium" San Antonio, Texas. |
| January 2001 | A. Carroll and J.S. Gunn."Identification and characterization of a novel two-component regulatory system in Salmonella typhimurium" Orlando, FL. |
| January 2001 | R. Tamayo, S.S. Ryan, A.J. McCoy, and J.S. Gunn."Identification and chracterization of Salmonella typhimurium PmrA-PmrB regulated genes and genes necessary for polymyxin resistance" San Antonio, Texas. |
| January 2001 | R. Tamayo, S.S. Ryan, A.J. McCoy, and J.S. Gunn."Identification and chracterization of Salmonella typhimurium PmrA-PmrB regulated genes and genes necessary for polymyxin resistance" Orlando, FL. |
| January 2001 | J.S. Gunn, A.J. McCoy, L. Tran, H. Liu, and T. Falla."Identification and characterization of Burkholderia cepacia mutants sensitive to antimicrobial peptides" Orlando, FL. |
| January 2001 | Vivanco Cid Héctor, Maldonado Bernal Ma. Del Carmen, Pastelin Palacios Rodolfo, John S. Gunn, Alpuche Aranda Celia, Isibasi Armando, y López Macías Constantino."Efecto de las modificaciones estructurales del lipido a del lipopolisacarido de Salmonella typhimurium en la inducción de la respuesta inmune innata" Mexico City, Mexico. |
| January 2001 | TJ.S. Gunn, A.J. McCoy, and S.S. Ryan."The role of LPS modification in bacterial virulence and resistance to antimicrobial peptides" . |
| January 2002 | A.M. Prouty and J.S. Gunn."Bile resistance/response and gallstone biofilms in typhoid carriers" Salve Regina, RI. |
| January 2002 | A.C. Vallor, J.S. Gunn, and K.E. Klose."Construction of recombinant DNA plasmids carrying and expressing protective antigen (PA) from Bacillus anthracis and Tul4 and FopA from Francisella tularensis" Austin, Texas. |
| January 2002 | R. Tamayo, A.M. Prouty, and J.S. Gunn."Identification of Salmonella enterica serovar Typhimurium PmrA-regulated genes using DNA microarray analaysis" Austin, Texas. |
| January 2003 | A.M. Prouty and J.S. Gunn."Novel bile salt-mediated induction of antimicrobial resistance in Salmonella typhimurium" Ventura, CA. |
| January 2003 | A.C. Portillo and J.S. Gunn."Analysis of virulence phenotypes associated with the Salmonella typhimurium UblAB two-component regulatory system" Washington D.C.. |
| January 2003 | A. Carroll-Portillo, A. Prouty, J. Manos, R. Belas, J. Gunn."The role of UblAB in S. enterica serovar Typhimurium motility and type III secretion" . |
| January 2003 | R. Tamayo, L.T. Tran, J. Gunn."PmrA-mediated LPS modifications- Role in survival of S. enterica serovar Typhimurium" . |
| January 2003 | J. G. Mammarappallil, A. M. Prouty, J. S. Gunn."Characterization of the Salmonella typhimurium outer membrane virulence factor PagC" Washington D.C.. |
| January 2003 | D. A. Devine, S. Walling, M. M. Morgan, A. E. Ashcroft, W. A. Bonass, J. N. Keen, R. S. Percival, Z. Yousuf, J. Gunn."Interactions Between Antimicrobial Peptides and Polymyxin B Sensitive Burkholderia cepacia Mutants in Relation to Lipopolysaccharide Structure" Chicago, Illinois. |
| January 2004 | W. Navarre, T. Halsey, J. Frye, D. Walthers, M. McClelland, J. Potter, L. Kenney, J. Gunn, F. Fang , S. J. Libby."Apparent Regulation of SlyA Specificity by PhoP in Salmonella enterica" New Orleans, LA. |
| January 2004 | A.C. Vallor, C.M. Lauriano, J.L. Patterson, J.S. Gunn, and K.E. Klose."Evaluation of Attenuated Salmonella Typhimurium Vaccines Expressing Bacillus Anthracis Protective Antigen In Mice" Baltimore, MD. |
| January 2004 | S. Soni, K. E. Klose, J. S. Gunn."Construction of a Novel Live-Attenuated Vaccine for Food-Borne Pathogens" New Orleans, LA. |
| January 2004 | Mohapatra N., S. Soni, M.B. Perry, E. Vinogradov, and J.S. Gunn."Genetic and Structural Analysis if Francisella spp. LPS" East Lansing, MI. |
| January 2004 | Merighi, M, C.D. Ellermeier, J.M. Slauch, and J.S. Gunn."Recombination-based in vivo expression technology analysis shows extracellular expression of the Salmonella enterica sv. Typhimurium pmrHFIJKLM locus in the illeal lumen of BALB/c mice" East Lansing, MI. |
| January 2004 | Maier, R.J., A. Olczak, S. Maier, S. Soni, and J. Gunn."Role of hydrogen use in pathogenesis by infectious bacteria" Reading, England. |
| January 2004 | J.S. Gunn, S. Soni, R.W. Crawford, F.E. Nano, M.B. Perry, E.Vinogradov, and W.J. Conlan."Franciaella tularensis LPS Phase Variation: Role in Virulence and Innate Immune Killing" Baltimore, MD. |
| January 2005 | Mohapatra, N., S. Soni, A. Balagopal, L. S. Schlesinger, J. S. Gunn."AcpA, an Acid Phosphatase involved in FrancisellaVirulence" New York. |
| January 2005 | Mohapatra, N., S. Soni, A. Balagopal, L. S. Schlesinger, J. S. Gunn."The role of the acid phosphatase AcpA in virulence and intramacrophage survival of Francisella novicida" Minnesota. |
| January 2005 | Merighi, M., A. Carroll-Portillo, A. N. Septer, A. Bhatiya, J. S. Gunn."The Role of PreA/PreB two-component system in modulating PmrA-regulated gene transcription in Salmonella enterica serovar Typhimurium" Minnesota. |
| January 2005 | Bhatiya, A. and J.S. Gunn."Identification of PmrA-PmrB constitutive mutations in Salmonella enterica serovar Typhimurium" Minnesota. |
| January 2005 | A. Balagopal, A. Shearer Macfarlane, N. Mohapatra, S. Soni, J.S. Gunn, L.S. Schlesinger."Identification of receptor-ligand interactions that mediate entry of Francisella novicida and the Live Vaccine Strain of Francisella tularensis into human macrophages" Columbus, Ohio. |
| January 2005 | Soni, S., N. Mohapatra, M. Perry, E. Vinogradov, A. Muszynski, R. Carlson, A. Balagopal, L. S. Schlesinger, J. S. Gunn."The interplay between Francisella tularensis LPS phase variation and innate immunity" Minnesota. |
| January 2005 | Soni S., N. Mohapatra, M. Perry, E.Vinogradov , A. Muszynski, B. Choudhury, R. Carlson, A. Balagopal, L. S. Schlesinger, J. S. Gunn."Francisella tularensis LPS phase variation is not due to major structural alterations but affects intramacrophage survival" New York. |
| January 2005 | Devine DA, M.M. Morgan, A.E. Ashcroft, J. Keen, J.S. Gunn, R.S. Percival, W.A. Bonass, Z. Yousuf and P.D. Marsh."Environmental regulation in Burkholderia cenocepacia of cell components relevant to interactions with host defence peptides" . |
| January 2005 | Crawford R.W. and J. S. Gunn."Salmonella bile sensing and bile-mediated biofilm formation" Minnesota. |
| November 2006 | N.P. Mohapatra, S. Soni, T.J. Reilly, J. Liu, K.E. Klose and J.S. Gunn."Construction and characterization of a F. novicida strain containing multiple acid phosphatase gene deletions" Hilton Head. |
| November 2006 | M.V.S. Rajaram, L.P. Ganesan, K.V.L. Parsa, J.P. Butcher, J.S. Gunn, and S. Tridandapani."Protein kinase B/Akt modulates macrophage inflammatory response to Francisella tularensis infection and confers a survival advantage in mice" Woods Hole. |
| January 2006 | Shilpa Soni, Brian L. Bell, Richard Warren, Nrusingh P. Mohapatra, Corey D. Clay, Robert K. Ernst, Larry S. Schlesinger and John S. Gunn."Phenotypic and Genetic Changes in the Blue to Gray Phase Variation of Francisella tularensis" Wood Hole, NH. |
| January 2006 | Robert C. Crawford and John S. Gunn."Salmonella Bile Sensing and Bile-Mediated Biofilm Formation" Victoria, British Columbua. |
| January 2006 | Rajaram MVS, Ganesan LP, Parsa KVL, Butchar JP, Gunn JS and Tridandapani S."Protein Kinase B /Akt Modulates Macrophage Inflammatory Response to Fransicella tularensis Infection and Confers a Survival Advantage in Mice" Columbus, Ohio. |
| January 2006 | George Vangelakos, Erin K. Raulie, Jieh-Juen, John S. Gunn, James P. Chambers, M. Neal Guentzel, Bernard. P.Arulanandam."Proteases Produced by Francisella tularensis Inhibit the Activity of Alkaline Phosphatase in a Murine Model" New Hampshire. |
| January 2006 | Gavrilin MA , Bouakl I, Knatz NL, Duncan M, Hall M, Gunn JS, Wewers MD."Internalization and Phagosome Escape Required for Francisella to Induce Human Monocyte IL-1? Processing and Release" Columbus, Ohio. |
| January 2006 | Crawford, RW and Gunn JS."Salmonella bile sensing and bile-mediated biofilm formation" Cincinnati, Ohio. |
| January 2006 | Corey D. Clay, John S. Gunn, Larry S. Schlesinger."Differential complement activation and C3 component deposition on various Francisella tularensis subspecies and strains" Woods Hole, NH. |
| January 2006 | Clay, CD, Gunn, JS, Schlesinger, LS."Differential complement activation and C3 component deposition on various Francisella tularensis subspecies and strains" Hilton Head, SC. |
| January 2006 | Murugesan VS Rajaram, Latha P. ganesan, Kishore VL Parsa, Jonathan P. Butcher, John S. Gunn, and Susheela Tidandapani."Protein kinase B/Akt modulates macrophage inflammatory response to Francisella tularensis infection and confers a survival advantage in mice" Woods Hole, NH. |
| January 2006 | Abdelhakim Ben Nasr, Judith Haithcoat, Joseph P. Masterson, John S. Gunn, Tonya Eaves-Pyles, and Gary R. Klimpel."Critical Role for Serum Opsonins and Complement Receptors CR3 (CD11b/CD18) and CR4 (CD11c/CD18) in phagocytosis of Francisella tularensis by Human Dendritic Cells (DC): Uptake of Francisella Leads to Activation of Immature DCs and Intracellular Survival of the Bacteria" Woods Hole, NH. |
| January 2006 | A. Balagopal, A.S. MacFarlane, N. Mohapatra, S. Soni, J.S. Gunn, L.S. Schlesinger."Characterization of the receptor-ligand pathways important for entry and survival of Francisella novicida and the Live Vaccine Strain (LVS) of F. tularensis in human macrophages" Banff, Alberta. |
| November 2006 | C.D. Clay, J.S. Gunn, and L.S. Schlesinger."Differential complement activation and C3 component deposition on various Francisella tularensis subspecies and strains”." Woods Hole. |
| November 2006 | C.D. Clay, J.S. Gunn, and L.S. Schlesinger."Differential complement activation and C3 component deposition on various Francisella tularensis subspecies and strains" Hilton Head. |
| November 2006 | A. Ben Nasr, J. Haithcoat, J.P. Masterson, J.S. Gunn, T. Eaves-Pyles, and G.R. Klimpel."Critical Role for Serum Opsonins and Complement Receptors CR3 (CD11b/CD18) and CR4 (CD11c/CD18) in phagocytosis of Francisella tularensis by Human Dendritic Cells (DC): Uptake of Francisella Leads to Activation of Immature DCs and Intracellular Survival of the Bacteria" Woods Hole. |
| January 2006 | Parsa KVL, Ganesan LP, Rajaram MVS, Gavrilin MA, Balagopal A, Mohapatra NP, Wewers MD, Schlesinger LS, Gunn JS and Tridandapani S."Macrophage Pro-inflammatory Response to Francisella novicida Infection is Regulated by the SH2 Domain-containing Inositol 5’ Phosphatase SHIP" Columbus, Ohio. |
| January 2006 | Nrusingh P. Mohapatra, Shilpa Soni, Thomas J. Reilly, Jirong Liu, Karl E. Klose and John S. Gunn."Construction and characterization of a F. novicida strain containing multiple acid phosphatase gene deletions" Hilton Head, SC. |
| January 2006 | Nrusingh P. Mohapatra, Shilpa Soni, Thomas J. Reilly, Jirong Liu, Karl E. Klose and John S. Gunn."Construction and characterization of a F. novicida strain containing multiple acid phosphatase gene deletions" Woods Hole, NH. |
| January 2006 | Clay, CD, Gunn, JS, Schlesinger, LS."Differential complement activation and C3 component deposition on various Francisella tularensis subspecies and strains" Cincinnati, Ohio. |
| January 2006 | Clay, C. D., J. S. Gunn, L. S. Schlesinger."Francisella tularensis activates the complement system in human serum, but is resistant to complement-mediated lysis" Columbus, Ohio. |
| March 2007 | S. Richards and J.S. Gunn."Intestinal Innate Immunity and Salmonella Virulence" Columbus. |
| June 2007 | N.P. Mohapatra, S. Soni, J. Liu, K.E. Klose, J.S. Gunn.."Multiple deletions of acid phosphatases in Francisella novicida affect virulence, intramacrophage survival and trafficking" . |
| June 2007 | B.L. Bell, N.P. Mohapatra, R. Warren and J.S. Gunn."An Orphan Response Regulator that is Necessary for Francisella Virulence and Transcription of Pathogenicity Genes" . |
| March 2007 | C.D. Clay, J.S. Gunn, and L.S. Schlesinger."Differential complement activation and C3 component deposition on various Francisella tularensis subspecies and strains" Columbus. |
| March 2007 | B.L. Bell, N.P. Mohapatra, R. Warren and J.S. Gunn."An Orphan Response Regulator that is Necessary for Francisella Virulence and Transcription of Pathogenicity Genes" Columbus. |
| June 2007 | S. Soni, N. Mohapatra, M. Perry, E. Vinogradov , R.K. Ernst, C. Clay, B.L. Bell, L. S. Schlesinger , and J.S. Gunn."Francisella tularensis LPS phase variation and its role in innate immunity" . |
| September 2007 | C.D. Clay, J.S. Gunn, L.S. Schlesinger."Complement activation and component deposition on Francisella tularensis" Chicago. |
| June 2007 | S. Richards and J.S. Gunn."Intestinal Innate Immunity and Salmonella Virulence" . |
| September 2007 | S.M. Richards and J.S. Gunn."Environmental sensing by Salmonella two-component regulatory systems”" Chicago. |
| September 2007 | R.W. Crawford and J.S. Gunn."A bile-induced exopolysaccharide required for Salmonella biofilm formation" Chicago. |
| November 2007 | B.L. Bell, N.P. Mohapatra, R. Warren and J.S. Gunn."An Orphan Response Regulator that is Necessary for Francisella Virulence and Transcription of Pathogenicity Genes" Hilton Head. |
| April 2008 | S.M. Richards, M. Conroy and J.S. Gunn."PhoPQ- and PmrAB-mediated environmental sensing and lipid A modifications are involved in Salmonella virulence" Columbus. |
| April 2008 | M. Conroy, S.M. Richards and J.S. Gunn."The role of two component regulatory systems and LPS modifications in Salmonella enterica resistance to antimicrobial peptides.”" Columbus. |
| September 2008 | C.D. Clay, S. Soni, J.S. Gunn, and L.S. Schlesinger."LPS O-antigen dictates whether complement activation by Francisella tularensis results in microbial lysis by regulating C3 deposition"." Madison. |
| September 2008 | B.L. Bell, N. P. Mohapatra and J. S. Gunn."PmrA is a Francisella Orphan Response Regulator that Binds Regulated Promoters and Activates Virulence Factor Expression" Columbus. |
| September 2008 | B. Bullard, G. Gonzalez, R.W. Crawford and J.S. Gunn."Bile Induced Repression of the Salmonella Typhimurium SPI-1 Type Three Secretion System" Columbus. |
| September 2008 | B. Bullard, G. Gonzalez, R.W. Crawford and J.S. Gunn."Bile Induced Repression of the Salmonella Typhimurium SPI-1 Type Three Secretion System" Madison. |
| March 2008 | B.L. Bell, N. P. Mohapatra and J. S. Gunn."A Francisella Orphan Response Regulator Required for Transcription of Pathogenicity Genes and Virulence" Bolton Landing. |
| April 2008 | C.D. Clay, S. Soni, J.S. Gunn, and L.S. Schlesinger."Evasion of complement-mediated lysis by Francisella tularensis" Columbus. |
| September 2008 | S.M. Richards, M. Conroy, J. Fierer and J.S. Gunn.."The role of antimicrobial peptides and the microflora in the oral virulence defect of Salmonella aminoarabinose-deficient mutants" Madison. |
| September 2008 | S.M. Richards, M. Conroy, J. Fierer and J.S. Gunn."The role of antimicrobial peptides and the microflora in the oral virulence defect of Salmonella aminoarabinose-deficient mutants" Columbus. |
| April 2009 | S.M. Richards, M. Conroy, J. Fierer, S.P. Colgan, G.O. Canny and J.S. Gunn."The role of antimicrobial peptides and the microflora in host selection against Salmonella strains deficient in LPS modification" Columbus. |
| April 2009 | R.W. Crawford, K.E. Reeve, and J.S. Gunn."Flagellar filament mediates Salmonella binding to and biofilm initiation on cholesterol" Columbus. |
| April 2009 | C.D. Clay, S. Soni, J.S. Gunn, and L.S. Schlesinger.."LPS O-antigen dictates whether complement activation by Francisella tularensis results in microbial lysis by regulating C3 deposition" Columbus. |
| April 2009 | B.L. Bell, N. P. Mohapatra and J. S. Gunn."A Francisella Orphan Response Regulator Required for Transcription of Pathogenicity Genes and Virulence" Columbus. |
| April 2009 | B. Bullard, G. Gonzalez, R.W. Crawford and J.S. Gunn."Bile Induced Repression of the Salmonella Typhimurium SPI-1 Type Three Secretion System" Columbus. |
| September 2009 | B. Kim, S. M. Richards, J. S. Gunn and J. M. Slauch."The Role Of Periplasmic Cu/Zn Superoxide Dismutases Of Salmonella Typhimurium In Protection Against Phagocytic Superoxide" . |
| October 2009 | S.M. Richards and J.S. Gunn."The role of antimicrobial peptides in host selection against Salmonella strains deficient in LPS modification" Aix-en-Provence. |
| October 2009 | R.W. Crawford, K.E. Reeve, and J.S. Gunn."Salmonella Flagella Mediate Binding to Cholesterol during Biofilm Formation" Aix-en-Provence. |
| October 2009 | G. Gonzalez-Escobedo, B. Bullard, R.W. Crawford and J. S. Gunn."Bile Induced Repression of the Salmonella Typhimurium SPI-1 Type Three Secretion System" Aix-en-Provence. |
| May 2009 | R.W. Crawford, K.E. Reeve, and J.S. Gunn.."Salmonella Flagella Mediate Binding to Cholesterol during Biofilm Formation" Columbus. |
| April 2010 | S. M. Richards, M. E. Conroy, K. Strandberg and J. S. Gunn."S. Typhi and S. Typhimurium Exhibit Variations in PhoPQ- and PmrAB-regulated LPS Modifications and Antimicrobial Peptide Resistance" Columbus. |
| October 2010 | N. N. Jarjour, K. L. Strandberg and J. S. Gunn."Modulation of the innate immune response by Salmonella lipopolysaccharide modification" Columbus. |
| January 2010 | C.L. Chen, A. Radulescu, I. A.-O. James, H.Y. Zhang, J. S. Gunn and G. E. Besner."HB-EGF Promotes α-defensin Secretion from Intestinal Paneth Cells”" . |
| April 2010 | G. Gonzalez-Escobedo and J. S. Gunn."Biofilm and cholesterol mediated transcriptional responses in Salmonella spp" Columbus. |
| September 2010 | S. M. Richards, M. E. Conroy, K. Strandberg and J. S. Gunn."S. Typhi and S. Typhimurium LPS modification mutants exhibit increased sensitivity to antimicrobial peptides and reduced intracellular survival" St. Louis. |
| March 2010 | K. L. Strandberg, S. M. Richards, C. Chen, G. M. Besner, and J. S. Gunn."In vivo PhoP/PhoQ- and PmrA/PmrB-Induced Lipopolysaccharide Modifications Alter Innate Immune Responses in the Mouse Intestine”," Columbus. |
| March 2010 | K. E. Reeve, R. W. Crawford, and J. S. Gunn."Identification of Salmonella enterica serovar Typhimurium genes required for biofilm formation on cholesterol-coated surfaces" Columbus. |
| March 2010 | G. Gonzalez-Escobedo and J. S. Gunn."Biofilm and cholesterol mediated transcriptional responses in Salmonella spp.”," Columbus. |
| April 2010 | K. L. Strandberg, S. M. Richards, C. Chen, G. M. Besner, and J. S. Gunn."Effects of PhoP/PhoQ- and PmrA/PmrB-Induced Lipopolysaccharide Modifications on Innate Immune Responses in the Mouse Intestine" Columbus. |
| May 2010 | N. N. Jarjour, K. L. Strandberg, and J. S. Gunn."Modulation of innate immunity by Salmonella lipopolysaccharide modification"," Columbus. |
| May 2010 | K. E. Reeve, R. W. Crawford, and J. S. Gunn."Salmonella Genes Required for Biofilm Formation on Cholesterol Surfaces" Columbus. |
| October 2010 | Kristi L. Strandberg, Susan M. Richards, and John S. Gunn."Effects Of PhoP/PhoQ- And PmrA/PmrB-Induced Lipopolysaccharide Modifications On Innate Immune Responses In The Mouse Intestine" . |
| October 2010 | K.L. Strandberg, S.M. Richards, J.S. Gunn."Effects of PhoP/PhoQ- and PmrA/PmrB-induced lipopolysaccharide modifications on Innate Immune responses in the mouse intestine" . |
| March 2010 | S. Soni, N. P. Mohapatra and J. S. Gunn."Environmental modulation and intraspecies variation of the PmrA-KdpD two-component Regulatory system of Francisella tularensis" Columbus. |
| March 2010 | S. M. Richards, M. E. Conroy, K. Strandberg and J. S. Gunn."S. Typhi and S. Typhimurium Exhibit Variations in PhoPQ- and PmrAB-regulated LPS Modifications and Antimicrobial Peptide Resistance" Columbus. |
| March 2011 | S.M. Richards, M. Conroy, J. Fierer, S.P. Colgan, G.O. Canny and J.S. Gunn."The role of antimicrobial peptides and the microflora in host selection against Salmonella strains deficient in LPS modification" Ventura. |
| March 2011 | N. P. Mohapatra, A. Harrison, S. Soni and J. S. Gunn."Regulation of Francisella tularensis virulence factors by small non-coding RNAs" Ventura. |
| April 2011 | G. Gonzalez-Escobedo and J.S. Gunn."Salmonella spp. mechanisms for persistence in the gallbladder during chronic typhoid carriage" Columbus. |
| June 2011 | G. Gonzalez-Escobedo and J.S. Gunn."Biofilm genes specifically regulated on gallstone (cholesterol) surfaces" Geneva. |
| August 2011 | N. N. Jarjour, K. L. Strandberg, and J. S. Gunn."Modulation of innate immunity by Salmonella lipopolysaccharide modification" Irvine. |
| April 2011 | S. Dai, H.M. Curry, J.S. Gunn and L. S. Schlesinger."A link between complement receptor 3-mediated uptake of Francisells tularensis and immune suppression in human macrophages" Columbus. |
| July 2011 | Kristi L. Strandberg and John S. Gunn."Effects of Salmonella PhoP-PhoQ- and PmrA-PmrB-mediated lipopolysaccharide modifications on LL-37 expression in human monocyte-derived macrophages" . |
| April 2011 | Kristi L. Strandberg, Susan M. Richards, and John S. Gunn.."Effects Of PhoP/PhoQ- And PmrA/PmrB-Induced Lipopolysaccharide Modifications On Innate Immune Responses In The Mouse Intestine" Columbus. |
Presentations
"In vivo regulated Salmonella LPS modifications and intramacrophage survival." Presented at Texas Branch ASM, . (January 1998)
"The Salmonella typhimurium PhoP-PhoQ regulon: Role in resistance to antimicrobial peptides." Presented at Trinity University, . (June 1998)
"The Salmonella PhoP-PhoQ two-component regulatory system: Role in resistance to mammalian antimicrobial factors." Presented at Texas Branch ASM, . (January 1999)
"In vivo regulated Salmonella LPS modifications: Role in pathogenesis." Presented at University of Texas, . (January 1999)
"The Role of LPS Modification in Bacterial Virulence and Resistance to Antimicrobial Peptides." Presented at Texas Branch ASM, . (January 2000)
"The Interaction of Salmonellae With Gallstone Surfaces." Presented at Texas Branch ASM, . (January 2000)
"The Interaction of Salmonellae With Bile and Gallstone Surfaces." Presented at Texas Lutheran University, . (January 2000)
"Identification of Proteus mirabilis and Burkholderia cepacia Mutants sensitive to Polymyxin and IB-367." Presented at IntraBiotics Pharmaceuticals, Inc, . (January 2000)
"Bacterial Modification of LPS and Resistance to Antimicrobial Peptides." Presented at International Endotoxin Society, . (August 2000)
"Bile and biofilms: a complex interaction involved in chronic Salmonella carriage?." Presented at University of Texas at El Paso, . (January 2001)
"The Interaction of Salmonellae With Bile and Gallstone Surfaces." Presented at Case Western Reserve University, . (January 2002)
"The Interaction of Salmonellae With Bile and Gallstone Surfaces." Presented at Mexican Society of Infectious Diseases and Clinical Microbiology (Asociación Mexicana de Enfermedades Infecciosas y MicrobiologÃa ClÃnica - -AMIMC-) XXVII annual meeting, . (January 2002)
"Salmonella Resistance and Response to Bile: Life in the Intestine and Gallbladder." Presented at Texas Branch ASM, . (January 2002)
"Regulated mechanisms of bacterial resistance to antimicrobial peptides." Presented at University of Texas Medical Branch, . (January 2002)
"LPS Modifications and Regulated Resistance to Antimicrobial Peptides in Salmonella typhimurium." Presented at The Ohio State University, . (January 2002)
"Gallstone Biofilms and Bile Resistance/Response in Acute and Chronic Salmonella Infections." Presented at Bowling Green State University, . (January 2002)
"Covalent LPS Modifications and Regulated Resistance to Antimicrobial Peptides in Salmonella typhimurium." Presented at North Carolina State University, . (January 2002)
"Covalent LPS Modifications and Regulated Resistance to Antimicrobial Peptides in Salmonella typhimurium." Presented at University of Houston, . (January 2002)
"Bile Resistance/Response and Gallstone Biofilms in Typhoid Carriers." Presented at North Carolina Central University, . (February 2002)
"The Interaction of Salmonella with Bile and Gallstone Surfaces." Presented at ASM Conference on Salmonella, . (September 2003)
"Mechanisms of antimicrobial peptide resistance in diverse gram negative bacteria." Presented at Gordon Conference, Antimicrobial Peptides, . (April 2003)
"Regulated Mechanisms Of Bacterial Resistance To Antimicrobial Peptide Killing." Presented at Midwest Pathogenesis Meeting, . (October 2003)
"Regulated Mechanisms Of Bacterial Resistance To Antimicrobial Peptide Killing." Presented at Universidad Nacional Autómona de México, . (October 2003)
"Regulated LPS Modification and Resistance to Innate Immune Killing." Presented at Medical College of Ohio, . (April 2004)
"Francisella LPS Structure and Phase Variation." Presented at NIAID-Sponsored Tularemia Workshop, . (October 2004)
"Progress of the Tularemia RCE Project." Presented at Western Regional Center of Excellence for Biodefense and Emerging Infectious Diseases, . (November 2004)
"Regulated Modification of Bacterial LPS." Presented at Glycostructures in Biological Systems XIII Symposium, . (December 2004)
"The Interaction of Salmonella with Bile and Gallstone Surfaces." Presented at Hospital Infantil de Mexico, . (September 2005)
"Francisella LPS: phase variation, structure, and role in pathogenesis." Presented at Tularemia Workshop, . (November 2005)
Presented at Resistance and Pathogenesis Discussion Leader, . (March 2005)
"Salmonella Regulatory Networks, Cell Surface Modifications and Resistance to Innate Immune Killing." Presented at Microbiology Department, The Ohio State University, . (September 2005)
"Regulation of Salmonella LPS Modification: Genes Required for Virulence and Resistance to Antimicrobial Peptides." Presented at Salmonella Infections: The Immune Defenses, . (September 2005)
"The Interaction of Salmonella with Bile and Gallstone Surfaces." Presented at Ohio Branch ASM Meeting, . (April 2005)
"Salmonella Host Adaptation and Survival in the Intestine and Gallbladder." Presented at University of Washington Microbiology Department, . (January 2006)
"Bacterial regulatory networks, LPS modification and resistance to antimicrobial peptides." Presented at 2006 ASM General Meeting, . (January 2006)
"Host sensing and bacterial surface modifications are important for Salmonella in vivo survival." Presented at University of Tennessee Microbiology Department, . (September 2006)
"Salmonella Host Adaptation and Survival in the Intestine and Gallbladder." Presented at University of Maryland Department of Cell Biology and Molecular Genetics, . (October 2006)
"Identification of an orphan response regulator required for Francisella virulence and transcription of pathogenicity island genes." Presented at 5th International Conference on Tularemia, . (November 2006)
"Identification of an orphan response regulator required for Francisella virulence and transcription of pathogenicity island genes." Presented at GLRCE Annual Meeting, . (November 2006)
"“Something about Mary that we never knew: typhoid, biofilms and gallstones�." Presented at Drexel University School of Medicine ASM Branch Meeting, . (May 2007)
"Francisella Intramacrophage Survival: Phosphatases and Virulence Gene Regulators�." Presented at University of Texas Southwestern, . (April 2007)
"“Salmonella Sensing of and Adaptation to the in vivo Environment�." Presented at University of Texas at San Antonio, . (October 2007)
"“Salmonella Sensing of and Adaptation to the in vivo Environment�." Presented at Miami University, . (October 2007)
"“Francisella Intramacrophage Survival: Phosphatases and Virulence Gene Regulators�." Presented at Albany Medical School, . (September 2007)
"“BSL-3 Research and Facilities at The Ohio State University�." Presented at Louisville Biodefense Meeting, . (January 2007)
"“Salmonella Host Adaptation and Survival in the Intestine and Gallbladder�." Presented at Wake Forest University, . (March 2007)
"“Salmonella Host Adaptation and Survival in the Intestine and Gallbladder�." Presented at University of South Florida, . (August 2007)
"“Chronic Carriage of Salmonella: Biofilms and Gallstones�." Presented at University of Rochester, . (November 2007)
"“Salmonella spp Response to Bile: Implications for Gallbladder Chronic Carriage�." Presented at Uniformed Services University of the Health Sciences, . (March 2008)
". “Francisella Intramacrophage Survival: Phosphatases and Virulence Gene Regulators�." Presented at Tularemia Workshop, . (March 2008)
"“Francisella Intramacrophage Survival: Phosphatases and Virulence Gene Regulators�." Presented at University of Kansas, . (March 2008)
"“Francisella Intramacrophage Survival: Phosphatases and Virulence Gene Regulators�." Presented at Albany Medical Center, . (May 2008)
""Francisella acid phosphatases dephosphorylate and inactivate host NADPH oxidase complex components in human phagocytes�." Presented at GLRCE Annual Meeting, . (November 2008)
"“Biofilms, Gallstones and Salmonella Gallbladder Carriage�." Presented at Texas A&M University, . (December 2008)
"“Francisella Intramacrophage Survival: Phosphatases and Virulence Gene Regulators�." Presented at 2008 American Society for Microbiology Annual Meeting, . (June 2008)
"Gallbladder carriage of Salmonella in mouse and man is enhanced by biofilm formation on gallstone surfaces." Presented at Iowa, IA. (September 2009)
"Gallstones play a significant role in Salmonella spp. gallbladder colonization and carriage." Presented at 3rd ASM Conference on Salmonella, . (October 2009)
"Gallbladder carriage of Salmonella in mouse and man is enhanced by biofilm formation on gallstone surfaces." Presented at ASM Biofilms Conference, . (November 2009)
"Salmonella adaptation to the host environment: innate immune resistance and chronic carriage." Presented at University of Florida, . (March 2010)
"Francisella Intramacrophage Survival: Phosphatases and Virulence Gene Regulators." Presented at Nationwide Children’s Hospital, Columbus, OH. (February 2010)
"Biofilms, Gallstones and Salmonella Gallbladder Carriage." Presented at University of Massachusetts, . (March 2011)
"Regulation of Francisella tularensis virulence factors by small non-coding RNAs." Presented at RCE National Conference, Denver, CO. (April 2011)