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Jian Zhang, PhD


460 W 12th Ave
Columbus, OH 43210

Phone: (614) 292-9447

Email: zhang.3570@osu.edu

 

Current OSU Appointments

Associate Professor, SBS-Microbial Infectn/Immunity

Associate Professor, Immunology & Rheumatology

 

Noteworthy Graduate Narrative

Trainee Awards/Fellowships/Publications

I have mentored several visiting graduate students from Central South University, China, and served/serve as the primary research advisor during their stay in my lab. One of these students (Yun Xiao) just had a manuscript published in Nature Medicine. Currently I am mentoring two graduate students from the Ohio State University Biomedical Science Graduate Program (BSGP):

04/16-present:&emspPatrick Kwadwo Nuro-Gyina, graduate student
Project-Nedd4 in Innate and Adaptive Immunity: The project will determine whether Nedd4 regulates anti-fungal innate immune responses and the development of T follicular helper cells.
Patrick Kwadwo Nuro-Gyina was a DISCOVERY PREP student at OSU.

08/16-present:&emspShurui Cai, graduate student
Project-Cbl-b in the development of innate lymphoid cells: The project will explore the novel role of Cbl-b in the development innate lymphoid cells

Best Abstract Award:
Fungal Recognition Mediated by C-Type Lectin Receptors Dectin-1 and Dectin-2 Is Regulated by E3 Ubiquitin Ligase Cbl-b
Juan Tang, Visiting Graduate Student, Midwest Microbial Pathogenesis Conference, August 28-30, 2015, Indianapolis, IN


Publications from Visiting graduate students:
07/06-08/09:&emspHaiyan Ying, Visiting graduate student,Shanghai Institutes for Biological Sciences, Shanghai, P.R. China

Project: Cbl-b in Th2 and Th17 cell development and autoimmunity

Publications:
1. Qiao, G., Lei, M., Li, Z., Sun, Y., Minto, AW., Ying, H., Quigg, RJ., and ZHANG, J. Negative regulation of CD40-mediated B cell response by E3 ubiquitin ligase Cbl-b. J. Immunol. 179:4473, 2007 (PMID: 17878343)

2. Ying, H., Yang, L., Qiao, G., Li, Z., Xie, D., and ZHANG, J. Cutting Edge: CTLA-4-B7 interaction suppresses Th17 differentiation. J. Immunol. 185:1375, 2010

3. Ying, H., Li, Z., and ZHANG, J.: Syk mediates BCR- and CD40-signaling integration during B cell activation. Immunobiology 216:566, 2011

4. Yang, L., Qiao, G., Ying, H., ZHANG, J., and Yin, F.: TCR-induced Akt Ser473 phosphorylation is regulated by PKC-alpha. Biochem Biophys. Res. Commun. 400:16, 2010

5. Guo, H., Qiao, G., Ying, H., Li, Z., Zhao, Y., Liang, Y., Lipkowitz, S., Penninger, J.M., Langdon, W.Y., and ZHANG, J. E3 ubiquitin ligase Cbl-b regulates Pten via Nedd4 independently of its ubiquitin ligase activity. Cell Reports 1:472, 2012

6. Qiao, G., Yang, L., Li, Z., Ying, H., Hassen, Y., Yin, F., and ZHANG, J. Rapid Communications: Program death-1 regulates peripheral T cell tolerance via an anergy-independent mechanism. Clin. Immunol. 143:128, 2012

7. Qiao, G., Ying, H., Liang, Y., Guo, H., Zhao, Y., Li, Z., Chen, B., Zhu, X., Solway, J., Lipkowitz, S., Penninger, J.M., Langdon, W.Y., and ZHANG, J. E3 ubiquitin ligase Cbl-b suppresses proallergic T cell development and allergic airway inflammation. Cell Reports 6:709, 2014 (Co-first author)

11/07-03/10: Lifen Yang, Visiting graduate student,Central South University, Changsha, Hunan, P.R. China

Projects: Identification of PDK-2 in T cells and PD-1 in autoimmune arthritis

Publications:
1. Yang, L., Qiao, G., Ying, H., ZHANG, J., and Yin, F.: TCR-induced Akt Ser473 phosphorylation is regulated by PKC-alpha. Biochem Biophys. Res. Commun. 400:16, 2010

2. Ying, H., Yang, L., Qiao, G., Li, Z., Xie, D., and ZHANG, J. Cutting Edge: CTLA-4-B7 interaction suppresses Th17 differentiation. J. Immunol. 185:1375, 2010 (Co-first author)

3. Qiao, G., Yang, L., Li, Z., Ying, H., Hassen, Y., Yin, F., and ZHANG, J. Rapid Communications: Program death-1 regulates peripheral T cell tolerance via an anergy-independent mechanism. Clin. Immunol. 143:128, 2012

4. Yang, L., Qiao, G., Hassan, Y., Li, Z., Zhang, X., Kong, H., Zeng, W., Yin, F., and ZHANG, J. Program Death-1 suppresses autoimmune arthritis by inhibiting Th17 response. Archivum Immunologiae et Therapiae Experimentalis 2016:in press (http://link.springer.com/article/10.1007%2Fs00005-016-0404-z)

10/10-09/13: Yixia Zhao, Visiting graduate student, Central South University, Changsha, Hunan, P.R. China

Project: E3 ubiquitin ligase Cbl-b in Th cell development, autoimmune myocarditis and innate immune responses

Publications:
1. Guo, H., Qiao, G., Ying, H., Li, Z., Zhao, Y., Liang, Y., Lipkowitz, S., Penninger, J.M., Langdon, W.Y., and ZHANG, J. E3 ubiquitin ligase Cbl-b regulates Pten via Nedd4 independently of its ubiquitin ligase activity. Cell Reports 1:472, 2012

2. Qiao, G., Zhao, Y., Li, Z., Tang, P.Q., Yang, T., and ZHANG, J. T cell activation threshold regulated by E3 ubiquitin ligase Cbl-b determines the fate of inducible regulatory T cells. J. Immunol.; 191:632, 2013. (Co-first author)

3. Qiao, G., Ying, H., Liang, Y., Guo, H., Zhao, Y., Li, Z., Chen, B., Zhu, X., Solway, J., Lipkowitz, S., Penninger, J.M., Langdon, W.Y., and ZHANG, J. E3 ubiquitin ligase Cbl-b suppresses proallergic T cell development and allergic airway inflammation. Cell Reports 6:709, 2014 (Co-first author)

4. Zhao, Y., Lei, M., Wang, Z., Qiao, G., Yang, T., and ZHANG, J. TCR-induced, PKC-θ-mediated NF-κB activation is regulated by a caspase-8-caspase-9-caspase-3 cascade. Biochemical and Biophysical Research Communications 450:526, 2014

5. Zhao, Y., Guo, H., Qiao, G., Zucker, M., Langdon, W.Y., and ZHANG, J. E3 ubiquitin ligase Cbl-b regulates thymic-derived CD4+CD25+ regulatory T cell development by targeting Foxp3 for ubiquitination. J. Immunol. 194:1639, 2015

6. Xiao, Y., Tang, J., Guo, H., Zhao, Y., Rappleye, C., Rajaram, M., Schlesinger, L.S., Tao, L., Brown, G.D., Langdon, W.Y., Li, B.T., and ZHANG, J. Targeting Cbl-b as a potential therapeutic approach for disseminated candidiasis. Nat. Med. 2016:22:906 (Highlighted in News and Views by Nature Medicine and by PNAS Front Matter)

06/13- 05/15: Yun Xiao, Visiting graduate student,Central South University, Changsha, Hunan, P.R.China

Project: Regulation of host defense against fungal infection by protein ubiquitination

Publications:
1. Xiao, Y., Qiao, G., Tang, J., Tang, R., Guo, H., Warwar, S., Langdon, W.Y., Tao, L., and ZHANG, J. Protein tyrosine phosphatase SHP-1 modulates T cell responses by controlling Cbl-b degradation. J. Immunol. 195:4218, 2015

2. Xiao, Y., Tang, J., Guo, H., Zhao, Y., Rappleye, C., Rajaram, M., Schlesinger, L.S., Tao, L., Brown, G.D., Langdon, W.Y., Li, B.T., and ZHANG, J. Targeting Cbl-b as a potential therapeutic approach for disseminated candidiasis. Nat. Med. 2016:22:906 (Highlighted in News and Views by Nature Medicine and by PNAS Front Matter)

04/15-present: Juan Tang, Visiting graduate student, Central South University, Changsha, Hunan, P.R.China

Project: Protein ubiquitination in sepsis

Publications:
1. Xiao, Y., Qiao, G., Tang, J., Tang, R., Guo, H., Warwar, S., Langdon, W.Y., Tao, L., and ZHANG, J. Protein tyrosine phosphatase SHP-1 modulates T cell responses by controlling Cbl-b degradation. J. Immunol. 195:4218, 2015

2. Xiao, Y., Tang, J., Guo, H., Zhao, Y., Rappleye, C., Rajaram, M., Schlesinger, L.S., Tao, L., Brown, G.D., Langdon, W.Y., Li, B.T., and ZHANG, J. Targeting Cbl-b as a potential therapeutic approach for disseminated candidiasis. Nat. Med. 2016:22:906 (Highlighted in News and Views by Nature Medicine and by PNAS Front Matter)

09/15-present:&emspSong Ouyang, Visiting graduate student, Central South University, Changsha, Hunan, P.R.China

Project: Regulation of Tregs/Th17 and EAE by Akt-1 and Akt-2

Publications:
Xiao, Y., Tang, J., Guo, H., Zhao, Y., Rappleye, C., Rajaram, M., Schlesinger, L.S., Tao, L., Brown, G.D., Langdon, W.Y., Li, B.T., and ZHANG, J. Targeting Cbl-b as a potential therapeutic approach for disseminated candidiasis. Nat. Med. 2016:22:906 (Highlighted in News and Views by Nature Medicine and by PNAS Front Matter)

12/15-present:&emspQiuming Zeng, Visiting graduate student,Central South University, Changsha, Hunan, P.R.China

Project: Regulation of Th17 and Experimental autoimmune encephalomyelitis by Nedd4

Publications:
Xiao, Y., Tang, J., Guo, H., Zhao, Y., Rappleye, C., Rajaram, M., Schlesinger, L.S., Tao, L., Brown, G.D., Langdon, W.Y., Li, B.T., and ZHANG, J. Targeting Cbl-b as a potential therapeutic approach for disseminated candidiasis. Nat. Med. 2016:22:906 (Highlighted in News and Views by Nature Medicine and by PNAS Front Matter)

Advising Narrative

Samantha Warwar &emspUndergraduate Student
2014 Scholarship from Office of Undergraduate Research, OSU

Publication

Xiao, Y., Qiao, G., Guo, H., Warwar, S., Langdon, W.Y., Tao, L., and ZHANG, J. Protein tyrosine phosphatase SHP-1 modulates T cell responses by controlling Cbl-b degradation. J. Immunol. 195:4218, 2015

Research Funding

I have maintained active R01 grant funding (AI090901-11A1) for more than 10 years, and have recently renewed this R01 grant for an additional five years. In this R01 grant, we will test the hypothesis that Nedd4 positively regulates Th17 cell development by targeting RORγt for K63-linked polyubiquitination, thus regulating Th17 response and the susceptibility to EAE in mice, and possibly multiple sclerosis in humans. In addition to this R01 grant, I have secured two other R01 grants regarding Cbl-b in anti-fungal innate immunity and sepsis. We all know that due to the NIH budget constraints, many principal investigators lost their NIH funding. The total awarded amount of these three R01 grants is $5,675,378, with indirect costs of $1,904,483. In addition to my R01 funding, I am also a principal investigator on an American Heart Association Grant-in-Aid grant ($154,000 for two years), and Multi-PI on one R21 grant with Dr. Ruoning Wang ($201,500) and one Alliance for Lupus Research Target Identification in Lupus grant (with Dr. Wael Jarjour) ($579,300). Therefore, my research funding is outstanding.

Postdoctoral / Researcher Advising

I have mentored several postdoctoral fellows/scholars since 2004. Dr. Guilin Qiao was initially a postdoc in my lab, and became a research assistant professor. He published 16 papers during his stay in my lab including two Cell Reports papers as the first author.

Zhaoyuan Wang, &emspPostdoctoral Fellowship
Regulation of autoimmune myocarditis by cellular FLICE inhibitory protein, American Heart Association Midwest Affiliates

Guilin Qiao,&emsp&emspPostdoc/Research Assistant Professor
Best Abstract Award: E3 ubiquitin ligase Cbl-b negatively regulates T helper 2 cell response by targeting Stat6 for ubiquitination, 2011 Department of Medicine Research Day, The University of Chicago
Junior Faculty Travel award 2011, 98th AAI annual meeting, May 13-17, 2011, San Francisco, CA

Biographical

I graduated from Hunan Medical University with an M.D. degree in 1983 and M.S./Med. in 1988. I became an attending neurologist in 1988 after I had finished my three-year residency at the Department of Neurology, The First Affiliated Hospital of Hunan Medical University. In 1991, I secured an opportunity of being a Postdoctoral Fellow at Laboratoire d’Immunologie Hôpital in France. After I finished my two-year postdoctoral fellow program in France, I was promoted as an associate professor in the Department of Neurology, The Second Affiliated Hospital of Hunan Medical University in 1993. In 1994, I was awarded a postdoctoral fellowship by the Juvenile Diabetes Foundation International (JDFI) and became a postdoctoral fellow at the Autoimmunity Group of The John P. Robarts Research Institute in Canada (with Terry L. Delovitch). In 1999, I was offered a research assistant professor position in the Department of Orthopedic Surgery of Rush University Medical Center (RUMC), Rush University, Chicago. I moved to the Department of Medicine (Nephrology) at the University of Chicago in September of 2004 as a tenure-track assistant professor. In September of 2012, I was recruited to the Department of Microbial Infection and Immunity at OSU as a tenured associate professor.

During the last 12 years, I have established/maintained an active research program. Currently, my lab is supported by three NIH R01 awards (2016-2021), one R21 award (2015-2017), one American Heart Association Grant-in-aid (2016-2017), and one Target identification in lupus grant from the Alliance for Lupus Research (2015-2018). I have a total of 54 publications, and 28 of these publications were published after I became a tenure-track faculty in 2004. Eleven papers were published during the last four years after I moved to OSU including one at Nature Medicine and one at Cell Reports.

My h-index is 25 (Google Scholar)

https://scholar.google.com/citations?user=xRCsNxwAAAAJ&hl=en

Academic Advising

During the last 16 years, I have mentored 22 postdocs, visiting graduate students, graduate students, visiting scholars, research technicians, and undergraduate students. In addition, I have also mentored 4 summer high school students, and two of them were supported by the American Cancer Society-Illinois Division. Most of them became physician scientists in China, or academic or industrial researchers in US or China. I will highlight several successful trainees who have had productive careers during their stay in my lab:

1. Guilin Qiao&emsp&emspPostdoc/Research Assistant Professor
Dr. Guilin Qiao joined my lab in November of 2004 as a postdoc in the beginning, and rose to a research assistant professor in 2010. During his stay in my lab (2004-2012), he published 16 research articles in Clinical Immunology, Journal of Immunology, Cell Death & Differentiation, and Cell Reports. He also obtained several awards from the Department and American Association of Immunologists listed below:

Best Abstract Award, 2011
Department of Medicine Research Day, The University of Chicago
E3 ubiquitin ligase Cbl-b negatively regulates T helper 2 cell response by targeting Stat6 for ubiquitination

Junior Faculty Travel award 2011, 98th AAI annual meeting, May 13-17, 2011, San Francisco, CA

2. Haiyan Ying, Visiting Graduate Student (2006-2009)
Haiyan joined my lab as a visiting graduate student in the Committee on Immunology at the University of Chicago. She was mainly focused on CTLA-4-B7 interaction on Th17 response and autoimmune myocarditis and Cbl-b in Th2 cell development and allergic airway inflammation. Upon the completion of her studies in my lab, she published one Journal of Immunology Cutting Edge article and one Cell Reports article as the first author. She was also the first author on an Immunobiology paper.

3. Yixia Zhao, Visiting Graduate Student (2010-2013)
Yixia joined my lab as a visiting graduate student in the Committee on Immunology at the University of Chicago initially, and relocated with me to OSU in 2012. Her studies involved how Cbl-b regulates regulatory T cell development and Th2/ and Th9 cell development. During her three years' stay in my lab, Yixia published two papers in the Journal of Immunology and one in Cell Reports as the first or co-first author. She is now a physician scientist in China, and has obtained her own funding from the Natural National Science Foundation of China.

4.Yun Xiao, Visiting Graduate Student (2013-2015)
Yun joined my lab in June of 2013, and completed her studies in May of 2015. During her stay in my lab, Yun has made many accomplishments. First, she demonstrated how Cbl-b protein levels are regulated in T cells. She found that SHP-1 dephosphorylates Cbl-b and stabilizes Cbl-b in T cells. The manuscript describing this observation was published in the Journal of Immunology. Second, she first identified Cbl-b as the E3 ubiquitin ligase for C type lectin receptors dectin-1 and dectin-2, and targeting Cbl-b can be a potential therapeutic approach for disseminated candidiasis. This novel discovery was just published in Nature Medicine. Third, she established a novel lupus mouse model by crossing Cblb-/- or Cblb E3 dead knockin mice onto B6-lpr mice. These double mutant mice develop early onset and severe lupus-like syndrome. This project is currently supported by an Alliance for Lupus Research Target Identification Grant.

6. K08 Award Advisory Committee
2006-2011: Dr. Rebecca Shilling
ICOS Expression Levels and Th Development

I helped Dr. Shilling with her K08 career development award application, and was an advisory member of her K08 award. Dr. Shilling is now an associate professor at the University of Illinois at Chicago.

Academic Advising

2006 Guo, H., The Ohio State University. Graduated 0.
2015 Zeng, Q., The Ohio State University. Graduated 0. Nedd4 in TH17 Cell Development and Autoimmunity
2015 Ouyang, S., The Ohio State University. Graduated 0. Differential Regulation of Thymic-Derived Regulatory T cells and Experimental Autoimmune Encephalomyelitis
2015 Tang, J., The Ohio State University. Graduated 0. Regulation of Sepsis and Septic Shock by E3 Ubiquitin Ligase Cbl-b
2015 Tang, R., The Ohio State University. Graduated 0. Regulation of T Follicular Helper Cell Development by E3 Ubiquitin Ligase Cbl-b
2016 Nuro-Gyina, P., The Ohio State University. Graduated 0.
2016 Headley, C., The Ohio State University. Graduated 0.
2016 Cai, S., The Ohio State University. Graduated 0.
1999 - 2002 Bardos, B., Rush University Medical Center. Graduated 0.
2001 - 2002 Xu, J., Rush University Medical Center. Graduated 0.
2001 - 2003 Li, D., Rush University Medical Center. Graduated 0.
2005 - 2006 Hussien, Y., University Of Chicago. Graduated 0.
2005 - 2006 Lei, M., University Of Chicago. Graduated 0.
2005 - 2008 Wang, Z., University Of Chicago. Graduated 0.
2005 - 2009 Li, Z., University Of Chicago. Graduated 0.
2006 - 2009 Ying, H., University Of Chicago. Graduated 2010. CTLA-4-B7 Interaction Suppresses Th17 Cell Differentiation & E3 Ubiquitin Ligase Cbl-b Negatively Regulates T Helper 2 Cell Responses by Targeting Stat-6 for Ubiquitination
2007 - 2010 Yang, L., University Of Chicago. Graduated 2010. Studies of T Cell Receptor Signaling Pathway and Function of Co-Receptors
2006 - 2011 Shilling, R., University Of Chicago. Graduated 0.
2004 - 2012 Qiao, G., University Of Chicago. Graduated 0.
2010 - 2013 Zhao, Y., The Ohio State University. Graduated 2014. E3 ubiquitin ligase Cbl-b regulates CD4+ T cell differentiation and mediates asthma
2013 - 2015 Xiao, Y., The Ohio State University. Graduated 2016. Research of GSTA3 in renal interstitial fibrosis
2013 - 2015 Liu, Q., The Ohio State University. Graduated 0.
2013 - 2015 Warwar, S., The Ohio State University. Graduated 2015.
2014 - 2015 Stevens,J. , The Ohio State University. Graduated 2016.
 

Edited Books

Encyclopedia of Signaling Molecules (second edition): E3 ubiquitin ligase CBL-B (Springer)

 

Editorial Activities

2000 - present Arthritis & Rheumatism
2001 - present Journal of Leukocyte Biology
2003 - present Diabetes
2005 - present American Journal of Pathology
2006 - present Clinical Immunology
2006 - present Journal of American Society of Nephrology
2006 - present American Journal of Physiology: Gastrointestinal and Liver Physiology
2006 - 2010 Journal of Immunology
2007 - present Clinical and Experimental Immunology
2009 - present Journal of Immunological Methods
2010 - present Molecular and Cellular Biology
2011 - present BMC Immunology
2011 - present Cancer Research
2011 - present Proceedings of the National Academies of Sciences
2013 - present Journal of Biological Chemistry
2013 - present Frontiers in Cell and Developmental Biology
2014 - present Plos Pathogen
2014 - present PLOS ONE
2015 - present Archivum Immunologiae et Therapiae Experimentalis
2015 - present FEBS Letters
2015 - present Cell Reports
2015 - present Frontiers in Immunology
2016 - present Trends in Molecular Medicine
2016 - present Oncotargets
 

Honors

1991 - 1993 Postdoctoral Fellowship. Association Française contre les Myopathies.
1994 - 1996 Postdoctoral Fellowship. Juvenile Diabetes Research Foundation.
1998 - present Scientific Trainee Award. Canadian Diabetes Association.
2001 - present American Association of Immunologists (AAI) Travel Award to the 11th International Congress of Immunology. American Association of Immunologists (AAI).
2001 - present Association of Immunologists (AAI) Junior Faculty Award. Association of Immunologists (AAI).
2002 - 2003 Arthritis National Research Foundation Fellow. Arthritis National Research Foundation.
2002 - 2007 NIH-Supported Independent Scientist (K02). National Institutes of Health.
2008 - 2011 American Lung Association Career Investigator award (Upper Midwest). American Lung Association.
2012 - 2016 Guest Professorship. Central South University.
2013 - present Association of Immunologists (AAI) Lab Travel Faculty Award. Association of Immunologists (AAI).
2015 - present Association of Immunologists (AAI) Faculty Travel Faculty Award to the 4th European Congress of Immunology. Association of Immunologists (AAI).
 

Journal Articles

 

Inventions and Patents

Targeting Nedd4 as a Potential Therapeutical Approach for Multiple Sclerosis

 

Presentations

Sequestration of CD4-Lck from the TCR complex may elicit T cell unresponsiveness in NOD mice

p38 MAPK is involved in both TCR- and CD28-signaling pathways in murine primary T cells

CD28 costimulation corrects defective activation of MAPKs and transcription factors AP-1, NF-AT in thymocytes from nonobese diabetic mice

Caspases mediate T cell proliferation via the regulation of cell cycle progression

Cbl-b: A major player in T cell costimulation

Cbl-b: A major player in T cell costimulation

Cbl-b: A major molecule involved in CD28- and CTLA-4-mediated T cell costimulation

Cbl-b is a negative regulator of PI3-K and MAP kinases in T cells

Cbl-b in CD40-mediated B cell activation

Negative regulation of CD40-mediated B cell activation by E3 ubiquitin ligase Cbl-b

T cell activation: Regulation of Cbl-b expression by CD28 and CTLA-4

Cellular FLICE inhibitory protein: Role in autoimmunity

Cbl-b negatively regulates antigen receptor-induced NF-κB activation via controlling the assembly of PKC-θ/CARMA1/Bcl10/MALT1/IKK signaling complex in T cells

Cellular FLICE inhibitory protein: Role in autoimmunity

Negative regulation of CD40-mediated B cell responses by E3 ubiquitin ligase Cbl-b

Negative regulation of T helper 2 cell differentiation by E3 ubiquitin ligase Cbl-b

Regulation of Th2 differentiation by E3 ubiquitin ligase Cbl-b

New pathways and functions regulated by E3 ubiquitin ligase Cbl-b

New pathways and functions regulated by E3 ubiquitin ligase Cbl-b

New pathways and functions regulated by E3 ubiquitin ligase Cbl-b

New pathways and functions regulated by E3 ubiquitin ligase Cbl-b

Cbl-b suppresses T cell receptor-mediated Akt activation by inhibiting down-regulation of Pten activity via a Nedd4-dependent mechanism

Regulation of T cell activation and differentiation by E3 ubiquitin ligase Cbl-b

Regulation of T cell activation and differentiation by E3 ubiquitin ligase Cbl-b

Cbl-b in T cell activation and differentiation

Regulation of Pten activation by E3 ubiquitin ligase Cbl-b via Nedd4 in T cells

Cellular FLICE inhibitory protein in lupus

Cellular FLICE inhibitory protein in lupus

Cbl-b in T cell activation and differentiation

Regulation of T cell activation and differentiation by E3 ubiquitin ligase Cbl-b

Linking innate immune responses to autoimmunity by E3 ubiquitin ligase Cbl-b

Regulation of Inducible CD4+CD25+ regulatory T cells by E3 ubiquitin ligase Cbl-b

Regulation of T cell activation and differentiation by E3 ubiquitin ligase Cbl-b

Regulation of Naturally-Occurring CD4+CD25+ Regulatory T Cell Development by E3 Ubiquitin Ligase Cbl-b

Regulation of Th2 responses by E3 ubiquitin ligase Cbl-b

Regulation of Foxp3 expression by E3 ubiquitin ligase Cbl-b

Regulation of proallergic T cell development and allergic airway inflammation by E3 ubiquitin ligase Cbl-b

Putting a brake on T cells: Regulation of proallergic T cell development and allergic airway inflammation by E3 Ubiquitin Ligase Cbl-b

Putting a brake on T cells: Inhibition of T Cell Activation and Differentiation by E3 Ubiquitin Ligase Cbl-b

Fungal Recognition Mediated by C-Type Lectin Receptors Dectin-1 and Dectin-2 Is Regulated by E3 Ubiquitin Ligase Cbl-b

Regulation of T follicular helper cell development and fungal recognition by E3 ubiquitin ligase Cbl-b

Regulation of host defense against fungal infection by protein ubiquitination

Control of fungal recognition by E3 ubiquitin ligase Cbl-b

Control of fungal recognition by E3 ubiquitin ligase Cbl-b

Anti-Fungal Innate Immune Responses Mediated by C-Type Lectin Receptors Dectin-1 and Dectin-2 Is Regulated by E3 Ubiquitin Ligase Cbl-b

Regulation of innate and adaptive immune responses by E3 ubiquitin ligase Cbl-b

Targeting Cbl-b as a Potential Therapeutic Approach for Disseminated Candidiasis

Regulation of innate and adaptive immune responses by E3 ubiquitin ligase Cbl-b

Targeting CBLB as a potential therapeutic approach for disseminated candidiasis

Regulation of innate and adaptive immune responses by E3 ubiquitin ligase Cbl-b

Regulation of innate and adaptive immune responses by E3 ubiquitin ligase Cbl-b

 

Professional Activities

present Co-Organizer. Sino-US Joint Symposium on Immunology and Diseases.
 

Unpublished Works

GSTA3 attenuates renal interstitial fibrosis by inhibiting TGF-β-induced tubular epithelial-mesenchymal transition and fibronectin expression

Regulation of effector function of CNS autoreactive CD4 T cells through inhibitory receptors and IL-7Rα

Mycobacterium tuberculosis cell wall released fragments by the action of the human lung mucosa modulate macrophages to control infection in an IL-10-dependent manner.