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Jian Zhang, PhD


460 W 12th Ave
Columbus, OH 43210

Phone: (614) 292-9447

Email: zhang.3570@osu.edu

 

Current OSU Appointments

Associate Professor, SBS-Microbial Infectn/Immunity

Associate Professor, Immunology & Rheumatology

 

Noteworthy Graduate Narrative

Trainee Awards/Fellowships/Publications



I have mentored several visiting graduate students from Central South University, China, and served/serve as the primary research advisor during their stay in my lab. One of these students (Yun Xiao) just had a manuscript published in Nature Medicine. Currently I am mentoring two graduate students from the Ohio State University Biomedical Science Graduate Program (BSGP):



04/16-present: Patrick Kwadwo Nuro-Gyina, graduate student

Project-Nedd4 in Innate and Adaptive Immunity: The project will determine whether Nedd4 regulates anti-fungal innate immune responses and the development of T follicular helper cells.

Patrick Kwadwo Nuro-Gyina was a DISCOVERY PREP student at OSU.



08/16-present: Shurui Cai, graduate student

Project-Cbl-b in the development of innate lymphoid cells: The project will explore the novel role of Cbl-b in the development innate lymphoid cells



Best Abstract Award:

Fungal Recognition Mediated by C-Type Lectin Receptors Dectin-1 and Dectin-2 Is Regulated by E3 Ubiquitin Ligase Cbl-b

Juan Tang, Visiting Graduate Student, Midwest Microbial Pathogenesis Conference, August 28-30, 2015, Indianapolis, IN





Publications from Visiting graduate students:

07/06-08/09: Haiyan Ying, Visiting graduate student,Shanghai Institutes for Biological Sciences, Shanghai, P.R. China



Project: Cbl-b in Th2 and Th17 cell development and autoimmunity



Publications:

1. Qiao, G., Lei, M., Li, Z., Sun, Y., Minto, AW., Ying, H., Quigg, RJ., and ZHANG, J. Negative regulation of CD40-mediated B cell response by E3 ubiquitin ligase Cbl-b. J. Immunol. 179:4473, 2007 (PMID: 17878343)



2. Ying, H., Yang, L., Qiao, G., Li, Z., Xie, D., and ZHANG, J. Cutting Edge: CTLA-4-B7 interaction suppresses Th17 differentiation. J. Immunol. 185:1375, 2010



3. Ying, H., Li, Z., and ZHANG, J.: Syk mediates BCR- and CD40-signaling integration during B cell activation. Immunobiology 216:566, 2011



4. Yang, L., Qiao, G., Ying, H., ZHANG, J., and Yin, F.: TCR-induced Akt Ser473 phosphorylation is regulated by PKC-alpha. Biochem Biophys. Res. Commun. 400:16, 2010



5. Guo, H., Qiao, G., Ying, H., Li, Z., Zhao, Y., Liang, Y., Lipkowitz, S., Penninger, J.M., Langdon, W.Y., and ZHANG, J. E3 ubiquitin ligase Cbl-b regulates Pten via Nedd4 independently of its ubiquitin ligase activity. Cell Reports 1:472, 2012



6. Qiao, G., Yang, L., Li, Z., Ying, H., Hassen, Y., Yin, F., and ZHANG, J. Rapid Communications: Program death-1 regulates peripheral T cell tolerance via an anergy-independent mechanism. Clin. Immunol. 143:128, 2012



7. Qiao, G., Ying, H., Liang, Y., Guo, H., Zhao, Y., Li, Z., Chen, B., Zhu, X., Solway, J., Lipkowitz, S., Penninger, J.M., Langdon, W.Y., and ZHANG, J. E3 ubiquitin ligase Cbl-b suppresses proallergic T cell development and allergic airway inflammation. Cell Reports 6:709, 2014 (Co-first author)



11/07-03/10: Lifen Yang, Visiting graduate student,Central South University, Changsha, Hunan, P.R. China



Projects: Identification of PDK-2 in T cells and PD-1 in autoimmune arthritis



Publications:

1. Yang, L., Qiao, G., Ying, H., ZHANG, J., and Yin, F.: TCR-induced Akt Ser473 phosphorylation is regulated by PKC-alpha. Biochem Biophys. Res. Commun. 400:16, 2010



2. Ying, H., Yang, L., Qiao, G., Li, Z., Xie, D., and ZHANG, J. Cutting Edge: CTLA-4-B7 interaction suppresses Th17 differentiation. J. Immunol. 185:1375, 2010 (Co-first author)



3. Qiao, G., Yang, L., Li, Z., Ying, H., Hassen, Y., Yin, F., and ZHANG, J. Rapid Communications: Program death-1 regulates peripheral T cell tolerance via an anergy-independent mechanism. Clin. Immunol. 143:128, 2012



4. Yang, L., Qiao, G., Hassan, Y., Li, Z., Zhang, X., Kong, H., Zeng, W., Yin, F., and ZHANG, J. Program Death-1 suppresses autoimmune arthritis by inhibiting Th17 response. Archivum Immunologiae et Therapiae Experimentalis 2016:in press (http://link.springer.com/article/10.1007%2Fs00005-016-0404-z)



10/10-09/13: Yixia Zhao, Visiting graduate student, Central South University, Changsha, Hunan, P.R. China



Project: E3 ubiquitin ligase Cbl-b in Th cell development, autoimmune myocarditis and innate immune responses



Publications:

1. Guo, H., Qiao, G., Ying, H., Li, Z., Zhao, Y., Liang, Y., Lipkowitz, S., Penninger, J.M., Langdon, W.Y., and ZHANG, J. E3 ubiquitin ligase Cbl-b regulates Pten via Nedd4 independently of its ubiquitin ligase activity. Cell Reports 1:472, 2012



2. Qiao, G., Zhao, Y., Li, Z., Tang, P.Q., Yang, T., and ZHANG, J. T cell activation threshold regulated by E3 ubiquitin ligase Cbl-b determines the fate of inducible regulatory T cells. J. Immunol.; 191:632, 2013. (Co-first author)



3. Qiao, G., Ying, H., Liang, Y., Guo, H., Zhao, Y., Li, Z., Chen, B., Zhu, X., Solway, J., Lipkowitz, S., Penninger, J.M., Langdon, W.Y., and ZHANG, J. E3 ubiquitin ligase Cbl-b suppresses proallergic T cell development and allergic airway inflammation. Cell Reports 6:709, 2014 (Co-first author)



4. Zhao, Y., Lei, M., Wang, Z., Qiao, G., Yang, T., and ZHANG, J. TCR-induced, PKC-θ-mediated NF-κB activation is regulated by a caspase-8-caspase-9-caspase-3 cascade. Biochemical and Biophysical Research Communications 450:526, 2014



5. Zhao, Y., Guo, H., Qiao, G., Zucker, M., Langdon, W.Y., and ZHANG, J. E3 ubiquitin ligase Cbl-b regulates thymic-derived CD4+CD25+ regulatory T cell development by targeting Foxp3 for ubiquitination. J. Immunol. 194:1639, 2015



6. Xiao, Y., Tang, J., Guo, H., Zhao, Y., Rappleye, C., Rajaram, M., Schlesinger, L.S., Tao, L., Brown, G.D., Langdon, W.Y., Li, B.T., and ZHANG, J. Targeting Cbl-b as a potential therapeutic approach for disseminated candidiasis. Nat. Med. 2016:22:906 (Highlighted in News and Views by Nature Medicine and by PNAS Front Matter)



06/13- 05/15: Yun Xiao, Visiting graduate student,Central South University, Changsha, Hunan, P.R.China



Project: Regulation of host defense against fungal infection by protein ubiquitination



Publications:

1. Xiao, Y., Qiao, G., Tang, J., Tang, R., Guo, H., Warwar, S., Langdon, W.Y., Tao, L., and ZHANG, J. Protein tyrosine phosphatase SHP-1 modulates T cell responses by controlling Cbl-b degradation. J. Immunol. 195:4218, 2015



2. Xiao, Y., Tang, J., Guo, H., Zhao, Y., Rappleye, C., Rajaram, M., Schlesinger, L.S., Tao, L., Brown, G.D., Langdon, W.Y., Li, B.T., and ZHANG, J. Targeting Cbl-b as a potential therapeutic approach for disseminated candidiasis. Nat. Med. 2016:22:906 (Highlighted in News and Views by Nature Medicine and by PNAS Front Matter)



04/15-present: Juan Tang, Visiting graduate student, Central South University, Changsha, Hunan, P.R.China



Project: Protein ubiquitination in sepsis



Publications:

1. Xiao, Y., Qiao, G., Tang, J., Tang, R., Guo, H., Warwar, S., Langdon, W.Y., Tao, L., and ZHANG, J. Protein tyrosine phosphatase SHP-1 modulates T cell responses by controlling Cbl-b degradation. J. Immunol. 195:4218, 2015



2. Xiao, Y., Tang, J., Guo, H., Zhao, Y., Rappleye, C., Rajaram, M., Schlesinger, L.S., Tao, L., Brown, G.D., Langdon, W.Y., Li, B.T., and ZHANG, J. Targeting Cbl-b as a potential therapeutic approach for disseminated candidiasis. Nat. Med. 2016:22:906 (Highlighted in News and Views by Nature Medicine and by PNAS Front Matter)



09/15-present: Song Ouyang, Visiting graduate student, Central South University, Changsha, Hunan, P.R.China



Project: Regulation of Tregs/Th17 and EAE by Akt-1 and Akt-2



Publications:

Xiao, Y., Tang, J., Guo, H., Zhao, Y., Rappleye, C., Rajaram, M., Schlesinger, L.S., Tao, L., Brown, G.D., Langdon, W.Y., Li, B.T., and ZHANG, J. Targeting Cbl-b as a potential therapeutic approach for disseminated candidiasis. Nat. Med. 2016:22:906 (Highlighted in News and Views by Nature Medicine and by PNAS Front Matter)



12/15-present: Qiuming Zeng, Visiting graduate student,Central South University, Changsha, Hunan, P.R.China



Project: Regulation of Th17 and Experimental autoimmune encephalomyelitis by Nedd4



Publications:

Xiao, Y., Tang, J., Guo, H., Zhao, Y., Rappleye, C., Rajaram, M., Schlesinger, L.S., Tao, L., Brown, G.D., Langdon, W.Y., Li, B.T., and ZHANG, J. Targeting Cbl-b as a potential therapeutic approach for disseminated candidiasis. Nat. Med. 2016:22:906 (Highlighted in News and Views by Nature Medicine and by PNAS Front Matter)

Advising Narrative

Samantha Warwar Undergraduate Student

2014 Scholarship from Office of Undergraduate Research, OSU



Publication



Xiao, Y., Qiao, G., Guo, H., Warwar, S., Langdon, W.Y., Tao, L., and ZHANG, J. Protein tyrosine phosphatase SHP-1 modulates T cell responses by controlling Cbl-b degradation. J. Immunol. 195:4218, 2015

Research Funding

I have maintained active R01 grant funding (AI090901-11A1) for more than 10 years, and have recently renewed this R01 grant for an additional five years. In this R01 grant, we will test the hypothesis that Nedd4 positively regulates Th17 cell development by targeting RORγt for K63-linked polyubiquitination, thus regulating Th17 response and the susceptibility to EAE in mice, and possibly multiple sclerosis in humans. In addition to this R01 grant, I have secured two other R01 grants regarding Cbl-b in anti-fungal innate immunity and sepsis. We all know that due to the NIH budget constraints, many principal investigators lost their NIH funding. The total awarded amount of these three R01 grants is $5,675,378, with indirect costs of $1,904,483. In addition to my R01 funding, I am also a principal investigator on an American Heart Association Grant-in-Aid grant ($154,000 for two years), and Multi-PI on one R21 grant with Dr. Ruoning Wang ($201,500) and one Alliance for Lupus Research Target Identification in Lupus grant (with Dr. Wael Jarjour) ($579,300). Therefore, my research funding is outstanding.

Postdoctoral / Researcher Advising

I have mentored several postdoctoral fellows/scholars since 2004. Dr. Guilin Qiao was initially a postdoc in my lab, and became a research assistant professor. He published 16 papers during his stay in my lab including two Cell Reports papers as the first author.Zhaoyuan Wang, Postdoctoral Fellowship Regulation of autoimmune myocarditis by cellular FLICE inhibitory protein, American Heart Association Midwest AffiliatesGuilin Qiao, Postdoc/Research Assistant ProfessorBest Abstract Award: E3 ubiquitin ligase Cbl-b negatively regulates T helper 2 cell response by targeting Stat6 for ubiquitination, 2011 Department of Medicine Research Day, The University of ChicagoJunior Faculty Travel award 2011, 98th AAI annual meeting, May 13-17, 2011, San Francisco, CA

Biographical

I graduated from Hunan Medical University with an M.D. degree in 1983 and M.S./Med. in 1988. I became an attending neurologist in 1988 after I had finished my three-year residency at the Department of Neurology, The First Affiliated Hospital of Hunan Medical University. In 1991, I secured an opportunity of being a Postdoctoral Fellow at Laboratoire d’Immunologie Hôpital in France. After I finished my two-year postdoctoral fellow program in France, I was promoted as an associate professor in the Department of Neurology, The Second Affiliated Hospital of Hunan Medical University in 1993. In 1994, I was awarded a postdoctoral fellowship by the Juvenile Diabetes Foundation International (JDFI) and became a postdoctoral fellow at the Autoimmunity Group of The John P. Robarts Research Institute in Canada (with Terry L. Delovitch). In 1999, I was offered a research assistant professor position in the Department of Orthopedic Surgery of Rush University Medical Center (RUMC), Rush University, Chicago. I moved to the Department of Medicine (Nephrology) at the University of Chicago in September of 2004 as a tenure-track assistant professor. In September of 2012, I was recruited to the Department of Microbial Infection and Immunity at OSU as a tenured associate professor.



During the last 12 years, I have established/maintained an active research program. Currently, my lab is supported by three NIH R01 awards (2016-2021), one R21 award (2015-2017), one American Heart Association Grant-in-aid (2016-2017), and one Target identification in lupus grant from the Alliance for Lupus Research (2015-2018). I have a total of 54 publications, and 28 of these publications were published after I became a tenure-track faculty in 2004. Eleven papers were published during the last four years after I moved to OSU including one at Nature Medicine and one at Cell Reports.



My h-index is 25 (Google Scholar)



https://scholar.google.com/citations?user=xRCsNxwAAAAJ&hl=en

Academic Advising

During the last 16 years, I have mentored 22 postdocs, visiting graduate students, graduate students, visiting scholars, research technicians, and undergraduate students. In addition, I have also mentored 4 summer high school students, and two of them were supported by the American Cancer Society-Illinois Division. Most of them became physician scientists in China, or academic or industrial researchers in US or China. I will highlight several successful trainees who have had productive careers during their stay in my lab:1. Guilin Qiao Postdoc/Research Assistant ProfessorDr. Guilin Qiao joined my lab in November of 2004 as a postdoc in the beginning, and rose to a research assistant professor in 2010. During his stay in my lab (2004-2012), he published 16 research articles in Clinical Immunology, Journal of Immunology, Cell Death & Differentiation, and Cell Reports. He also obtained several awards from the Department and American Association of Immunologists listed below: Best Abstract Award, 2011Department of Medicine Research Day, The University of ChicagoE3 ubiquitin ligase Cbl-b negatively regulates T helper 2 cell response by targeting Stat6 for ubiquitinationJunior Faculty Travel award 2011, 98th AAI annual meeting, May 13-17, 2011, San Francisco, CA2. Haiyan Ying, Visiting Graduate Student (2006-2009)Haiyan joined my lab as a visiting graduate student in the Committee on Immunology at the University of Chicago. She was mainly focused on CTLA-4-B7 interaction on Th17 response and autoimmune myocarditis and Cbl-b in Th2 cell development and allergic airway inflammation. Upon the completion of her studies in my lab, she published one Journal of Immunology Cutting Edge article and one Cell Reports article as the first author. She was also the first author on an Immunobiology paper.3. Yixia Zhao, Visiting Graduate Student (2010-2013)Yixia joined my lab as a visiting graduate student in the Committee on Immunology at the University of Chicago initially, and relocated with me to OSU in 2012. Her studies involved how Cbl-b regulates regulatory T cell development and Th2/ and Th9 cell development. During her three years' stay in my lab, Yixia published two papers in the Journal of Immunology and one in Cell Reports as the first or co-first author. She is now a physician scientist in China, and has obtained her own funding from the Natural National Science Foundation of China.4.Yun Xiao, Visiting Graduate Student (2013-2015)Yun joined my lab in June of 2013, and completed her studies in May of 2015. During her stay in my lab, Yun has made many accomplishments. First, she demonstrated how Cbl-b protein levels are regulated in T cells. She found that SHP-1 dephosphorylates Cbl-b and stabilizes Cbl-b in T cells. The manuscript describing this observation was published in the Journal of Immunology. Second, she first identified Cbl-b as the E3 ubiquitin ligase for C type lectin receptors dectin-1 and dectin-2, and targeting Cbl-b can be a potential therapeutic approach for disseminated candidiasis. This novel discovery was just published in Nature Medicine. Third, she established a novel lupus mouse model by crossing Cblb-/- or Cblb E3 dead knockin mice onto B6-lpr mice. These double mutant mice develop early onset and severe lupus-like syndrome. This project is currently supported by an Alliance for Lupus Research Target Identification Grant.6. K08 Award Advisory Committee2006-2011: Dr. Rebecca Shilling ICOS Expression Levels and Th DevelopmentI helped Dr. Shilling with her K08 career development award application, and was an advisory member of her K08 award. Dr. Shilling is now an associate professor at the University of Illinois at Chicago.

Academic Advising

2006 Guo, H., The Ohio State University. Graduated 0.
2015 Zeng, Q., The Ohio State University. Graduated 0. Nedd4 in TH17 Cell Development and Autoimmunity
2015 Ouyang, S., The Ohio State University. Graduated 0. Differential Regulation of Thymic-Derived Regulatory T cells and Experimental Autoimmune Encephalomyelitis
2015 Tang, J., The Ohio State University. Graduated 0. Regulation of Sepsis and Septic Shock by E3 Ubiquitin Ligase Cbl-b
2015 Tang, R., The Ohio State University. Graduated 0. Regulation of T Follicular Helper Cell Development by E3 Ubiquitin Ligase Cbl-b
2016 Nuro-Gyina, P., The Ohio State University. Graduated 0.
2016 Headley, C., The Ohio State University. Graduated 0.
2016 Cai, S., The Ohio State University. Graduated 0.
1999 - 2002 Bardos, B., Rush University Medical Center. Graduated 0.
2001 - 2002 Xu, J., Rush University Medical Center. Graduated 0.
2001 - 2003 Li, D., Rush University Medical Center. Graduated 0.
2005 - 2006 Hussien, Y., University Of Chicago. Graduated 0.
2005 - 2006 Lei, M., University Of Chicago. Graduated 0.
2005 - 2008 Wang, Z., University Of Chicago. Graduated 0.
2005 - 2009 Li, Z., University Of Chicago. Graduated 0.
2006 - 2009 Ying, H., University Of Chicago. Graduated 2010. CTLA-4-B7 Interaction Suppresses Th17 Cell Differentiation & E3 Ubiquitin Ligase Cbl-b Negatively Regulates T Helper 2 Cell Responses by Targeting Stat-6 for Ubiquitination
2007 - 2010 Yang, L., University Of Chicago. Graduated 2010. Studies of T Cell Receptor Signaling Pathway and Function of Co-Receptors
2006 - 2011 Shilling, R., University Of Chicago. Graduated 0.
2004 - 2012 Qiao, G., University Of Chicago. Graduated 0.
2010 - 2013 Zhao, Y., The Ohio State University. Graduated 2014. E3 ubiquitin ligase Cbl-b regulates CD4+ T cell differentiation and mediates asthma
2013 - 2015 Xiao, Y., The Ohio State University. Graduated 2016. Research of GSTA3 in renal interstitial fibrosis
2013 - 2015 Liu, Q., The Ohio State University. Graduated 0.
2013 - 2015 Warwar, S., The Ohio State University. Graduated 2015.
2014 - 2015 Stevens,J. , The Ohio State University. Graduated 2016.
 

Edited Books

Tang, J., Zhang, J.. "Encyclopedia of Signaling Molecules (second edition): E3 ubiquitin ligase CBL-B (Springer)." Edited by Choi, S..

 

Editorial Activities

2000 - present Arthritis & Rheumatism
2001 - present Journal of Leukocyte Biology
2003 - present Diabetes
2005 - present American Journal of Pathology
2006 - present American Journal of Physiology: Gastrointestinal and Liver Physiology
2006 - present Clinical Immunology
2006 - present Journal of American Society of Nephrology
2006 - 2010 Journal of Immunology
2007 - present Clinical and Experimental Immunology
2009 - present Journal of Immunological Methods
2010 - present Molecular and Cellular Biology
2011 - present Proceedings of the National Academies of Sciences
2011 - present Cancer Research
2011 - present BMC Immunology
2013 - present Journal of Biological Chemistry
2013 - present Frontiers in Cell and Developmental Biology
2014 - present Plos Pathogen
2014 - present PLOS ONE
2015 - present FEBS Letters
2015 - present Cell Reports
2015 - present Frontiers in Immunology
2015 - present Archivum Immunologiae et Therapiae Experimentalis
2016 - present Oncotargets
2016 - present Trends in Molecular Medicine
 

Honors

1991 - 1993 Postdoctoral Fellowship. Association Française contre les Myopathies.
1994 - 1996 Postdoctoral Fellowship. Juvenile Diabetes Research Foundation.
1998 - present Scientific Trainee Award. Canadian Diabetes Association.
2001 - present American Association of Immunologists (AAI) Travel Award to the 11th International Congress of Immunology. American Association of Immunologists (AAI).
2001 - present Association of Immunologists (AAI) Junior Faculty Award. Association of Immunologists (AAI).
2002 - 2003 Arthritis National Research Foundation Fellow. Arthritis National Research Foundation.
2002 - 2007 NIH-Supported Independent Scientist (K02). National Institutes of Health.
2008 - 2011 American Lung Association Career Investigator award (Upper Midwest). American Lung Association.
2012 - 2016 Guest Professorship. Central South University.
2013 - present Association of Immunologists (AAI) Lab Travel Faculty Award. Association of Immunologists (AAI).
2015 - present Association of Immunologists (AAI) Faculty Travel Faculty Award to the 4th European Congress of Immunology. Association of Immunologists (AAI).
 

Journal Articles

Song, C, He, L, Zhang, J, Ma, H, Yuan, X, Hu, G, Tao, L, Zhang, J, Meng, J. "Fluorofenidone attenuates pulmonary inflammation and fibrosis via inhibiting the activation of NALP3 inflammasome and IL-1β/IL-1R1/MyD88 pathway." J Cell Mol Med. (January 0.): -.

Zhang, J, Cohen-Kaminsky, S, Berrih-Aknin, S. "Macrophage subpopulations in the thymic hyperplasia in patients with myasthenia gravis." Hum. Antibodies & Hybridomas. Vol. 6, (June 1995.): 153-.

Zhang,J; Cohen-Kaminsky,S; Berrih-Aknin,S. "Macrophage subpopulations in the thymic hyperplasia of patients with myasthenia gravis.." Human antibodies and hybridomas. Vol. 6, no. 4. (January 1995.): 153-160.

Zhang,J; Zhou,W,B; Wang,H,L; Guo,S,S. "The effects of T cell subpopulations and recombinant interleukin (IL)-2 on peripheral B cell function in patients with myasthenia gravis.." Human antibodies. Vol. 8, no. 2. (January 1997.): 90-94.

Salojin,K; Zhang,J; Cameron,M; Gill,B; Arreaza,G; Ochi,A; Delovitch,T,L. "Impaired plasma membrane targeting of Grb2-murine son of sevenless (mSOS) complex and differential activation of the Fyn-T cell receptor (TCR)-xi-Cb1 pathway mediate T cell hyporesponsiveness in autoimmune nonobese diabetic mice." JOURNAL OF EXPERIMENTAL MEDICINE. Vol. 186, no. 6. (September 1997.): 887-897.

Zhang,J; Salojin,K; Delovitch,T,L. "Sequestration of CD4-associated Lck from the TCR complex may elicit T cell hyporesponsiveness in nonobese diabetic mice." JOURNAL OF IMMUNOLOGY. Vol. 160, no. 3. (February 1998.): 1148-1157.

Zhang,J; Salojin,K; Gao,J,X; Cameron,M; Geisler,C; Delovitch,T,L. "TCR alpha beta chains associate with the plasma membrane independently of CD3 and TCR zeta chains in murine primary T cells." JOURNAL OF IMMUNOLOGY. Vol. 161, no. 6. (September 1998.): 2930-2937.

Salojin,K,V; Zhang,J; Madrenas,J; Delovitch,T,L. "T-cell anergy and altered T-cell receptor signaling: effects on autoimmune disease." IMMUNOLOGY TODAY. Vol. 19, no. 10. (October 1998.): 468-473.

Zhang,J; Salojin,K,V; Gao,J,X; Cameron,M,J; Bergerot,I; Delovitch,T,L. "p38 mitogen-activated protein kinase mediates signal integration of TCR/CD28 costimulation in primary murine T cells." JOURNAL OF IMMUNOLOGY. Vol. 162, no. 7. (April 1999.): 3819-3829.

Salojin,K,V; Zhang,J; Delovitch,T,L. "TCR and CD28 are coupled via ZAP-70 to the activation of the Vav/Rac-1-/PAK-1/p38 MAPK signaling pathway." JOURNAL OF IMMUNOLOGY. Vol. 163, no. 2. (July 1999.): 844-853.

Gao,J,X; Zhang,J; Awaraji,C; Bhatia,M; Jevnikar,A; Singh,B; Bell,D; Delovitch,T,L. "Preferential proliferation and differentiation of double-positive thymocytes into CD8(+) single-positive thymocytes in a novel cell culture medium." CELLULAR IMMUNOLOGY. Vol. 202, no. 1. (May 2000.): 41-53.

Salojin,K,V; Zhang,J; Meagher,C; Delovitch,T,L. "ZAP-70 is essential for the T cell antigen receptor-induced plasma membrane targeting of SOS and Vav in T cells." JOURNAL OF BIOLOGICAL CHEMISTRY. Vol. 275, no. 8. (February 2000.): 5966-5975.

Zhang,J; Mikecz,K; Finnegan,A; Glant,T,T. "Spontaneous thymocyte apoptosis is regulated by a mitochondrion-mediated signaling pathway." JOURNAL OF IMMUNOLOGY. Vol. 165, no. 6. (September 2000.): 2970-2974.

Zhang,J; Gao,J,X; Salojin,K; Shao,Q; Grattan,M; Meagher,C; Laird,D,W; Delovitch,T,L. "Regulation of Fas ligand expression during activation-induced cell death in T cells by p38 mitogen-activated protein kinase and c-Jun NH2-terminal kinase." JOURNAL OF EXPERIMENTAL MEDICINE. Vol. 191, no. 6. (March 2000.): 1017-1029.

Zhang,J; Bardos,T; Mikecz,K; Finnegan,A; Glant,T,T. "Impaired Fas signaling pathway is involved in defective T cell apoptosis in autoimmune murine arthritis." JOURNAL OF IMMUNOLOGY. Vol. 166, no. 8. (April 2001.): 4981-4986.

Zhang,J; Salojin,K,V; Delovitch,T,L. "CD28 co-stimulation restores T cell responsiveness in NOD mice by overcoming deficiencies in Rac-1/p38 mitogen-activated protein kinase signaling and IL-2 and IL-4 gene transcription." INTERNATIONAL IMMUNOLOGY. Vol. 13, no. 3. (March 2001.): 377-384.

Glant,T,T; Bardos,T; Vermes,C; Chandrasekaran,R; Valdez,J,C; Otto,J,M; Gerard,D; Velins,S; Lovasz,G; Zhang,J; Mikecz,K; Finnegan,A. "Variations in susceptibility to proteoglycan-induced arthritis and spondylitis among C3H substrains of mice - Evidence of genetically acquired resistance to autoimmune disease." ARTHRITIS AND RHEUMATISM. Vol. 44, no. 3. (March 2001.): 682-692.

Vermes,C; Jacobs,J,J; Zhang,J; Firneisz,G; Roebuck,K,A; Glant,T,T. "Shedding of the interleukin-6 (IL-6) receptor (gp80) determines the ability of IL-6 to induce gp130 phosphorylation in human osteoblasts." JOURNAL OF BIOLOGICAL CHEMISTRY. Vol. 277, no. 19. (May 2002.): 16879-16887.

Bardos,T; Czipri,M; Vermes,C; Zhang,J; Mikecz,K; Glant,T,T. "Continuous nasal administration of antigen is critical to maintain tolerance in adoptively transferred autoimmune arthritis in SCID mice." CLINICAL AND EXPERIMENTAL IMMUNOLOGY. Vol. 129, no. 2. (August 2002.): 224-231.

Zhang,J; Bardos,T; Li,D,D; Gal,I; Vermes,C; Xu,J,Y; Mikecz,K; Finnegan,A; Lipkowitz,S; Glant,T,T. "Cutting edge: Regulation of T cell activation threshold by CD28 costimulation through targeting Cbl-b for ubiquitination." JOURNAL OF IMMUNOLOGY. Vol. 169, no. 5. (September 2002.): 2236-2240.

Finnegan,A; Grusby,M,J; Kaplan,C,D; O'Neill,S,K; Eibel,H; Koreny,T; Czipri,M; Mikecz,K; Zhang,J. "IL-4 and IL-12 regulate proteoglycan-induced arthritis through stat-dependent mechanisms." JOURNAL OF IMMUNOLOGY. Vol. 169, no. 6. (September 2002.): 3345-3352.

Bardos,T; Zhang,J; Mikecz,K; David,C,S; Glant,T,T. "Mice lacking endogenous major histocompatibility complex class II develop arthritis resembling psoriatic arthritis at an advanced age." ARTHRITIS AND RHEUMATISM. Vol. 46, no. 9. (September 2002.): 2465-2475.

Bardos,T; Mikecz,K; Finnegan,A; Zhang,J; Glant,T,T. "T and B cell recovery in arthritis adoptively transferred to SCID mice: Antigen-specific activation is required for restoration of autopathogenic CD4(+) Th1 cells in a syngeneic system." JOURNAL OF IMMUNOLOGY. Vol. 168, no. 12. (June 2002.): 6013-6021.

Arreaza,G; Salojin,K; Yang,W; Zhang,J; Gill,B; Mi,Q,S; Gao,J,X; Meagher,C; Cameron,M; Delovitch,T,L. "Deficient activation and resistance to activation-induced apoptosis of CD8(+) T cells is associated with defective peripheral tolerance in nonobese diabetic mice." CLINICAL IMMUNOLOGY. Vol. 107, no. 2. (May 2003.): 103-115.

Finnegan,A; Kaplan,C,D; Cao,Y,X; Eibel,H; Glant,T,T; Zhang,J. "Collagen-induced arthritis is exacerbated in IL-10-deficient mice." ARTHRITIS RESEARCH & THERAPY. Vol. 5, no. 1. (January 2003.): R18-R24.

Bardos,T; Czipri,M; Vermes,C; Finnegan,A; Mikecz,K; Zhang,J. "CD4(+)CD25(+) immunoregulatory T cells may not be involved in controlling autoimmune arthritis." ARTHRITIS RESEARCH & THERAPY. Vol. 5, no. 2. (January 2003.): R106-R113.

Zhang,J,A; Bardos,T; Shao,Q; Tschopp,J; Mikecz,K; Glant,T,T; Finnegan,A. "IL-4 potentiates activated T cell apoptosis via an IL-2-dependent-mechanism." JOURNAL OF IMMUNOLOGY. Vol. 170, no. 7. (April 2003.): 3495-3503.

Zhang,J; Xu,X; Liu,Y. "Activation-induced cell death in T cells and autoimmunity.." Cellular & molecular immunology. Vol. 1, no. 3. (June 2004.): 186-192.

Zhang,J. "Ubiquitin ligases in T cell activation and autoimmunity." CLINICAL IMMUNOLOGY. Vol. 111, no. 3. (June 2004.): 234-240.

Zhang,J. "Ubiquitin ligases in T cell activation and autoimmunity." CLINICAL IMMUNOLOGY. Vol. 111, no. 3. (June 2004.): 234-240.

Glant,T,T; Adarichev,V,A; Nesterovitch,A,B; Szanto,S; Oswald,J,P; Jacobs,J,J; Firneisz,G; Zhang,J; Finnegan,A; Mikecz,K. "Disease-associated qualitative and quantitative trait loci in proteoglycan-induced arthritis and collagen-induced arthritis." AMERICAN JOURNAL OF THE MEDICAL SCIENCES. Vol. 327, no. 4. (April 2004.): 188-195.

Zheng,X,C; Gao,J,X; Chang,X; Wang,Y; Liu,Y; Wen,J; Zhang,H,M; Zhang,J; Liu,Y; Zheng,P. "B7-CD28 interaction promotes proliferation and survival but suppresses differentiation of CD4-CD8-T cells in the thymus." JOURNAL OF IMMUNOLOGY. Vol. 173, no. 4. (August 2004.): 2253-2261.

Li,D,D; Gal,I; Vermes,C; Alegre,M,L; Chong,A,SF; Chen,L,P; Shao,Q; Adarichev,V; Xu,X,M; Koreny,T; Mikecz,K; Finnegan,A; Glant,T,T; Zhang,J. "Cutting edge: Cbl-b: One of the key molecules tuning CD28- and CTLA-4-Mediated T cell costimulation." JOURNAL OF IMMUNOLOGY. Vol. 173, no. 12. (December 2004.): 7135-7139.

Chang,X; Chen,L; Wen,J; Godfrey,VL; Qiao,G; Hussien,Y; Zhang,J; Gao,JX. "Foxp3 controls autoreactive T cell activation through transcriptional regulation of early growth response genes and E3 ubiquitin ligase genes, independently of thymic selection." CLINICAL IMMUNOLOGY. Vol. 121, no. 3. (December 2006.): 274-285.

Qiao,G; Lei,M; Li,Z; Sun,Y; Minto,A; Fu,YX; Ying,H; Quigg,RJ; Zhang,J. "Negative regulation of CD40-mediated B cell responses by E3 ubiquitin ligase casitas-B-lineage lymphoma protein-B." JOURNAL OF IMMUNOLOGY. Vol. 179, no. 7. (October 2007.): 4473-4479.

Qiao,Guilin; Lei,Minxiang; Li,Zhenping; Sun,Yonglian; Minto,Andrew; Fu,Yang-Xin; Ying,Haiyan; Quigg,Richard,J; Zhang,Jian. "Negative regulation of CD40-mediated B cell responses by E3 ubiquitin ligase casitas-B-lineage lymphoma protein-B." JOURNAL OF IMMUNOLOGY. Vol. 179, no. 7. (October 2007.): 4473-4479.

Qiao,G; Li,Z; Molinero,L; Alegre,ML; Ying,H; Sun,Z; Penninger,JM; Zhang,J. "T-Cell receptor-induced NF-kappa B activation is negatively regulated by E3 ubiquitin ligase Cbl-b." MOLECULAR AND CELLULAR BIOLOGY. Vol. 28, no. 7. (April 2008.): 2470-2480.

Bao,L; Haas,M; Pippin,J; Wang,Y; Miwa,T; Chang,A; Minto,AW; Petkova,M; Qiao,G; Song,WC; Alpers,CE; Zhang,J; Shankland,SJ; Quigg,RJ. "Focal and segmental glomerulosclerosis induced in mice lacking decay-accelerating factor in T cells." JOURNAL OF CLINICAL INVESTIGATION. Vol. 119, no. 5. (May 2009.): 1264-1274.

Qiao,G; Li,Z; Minto,A,W; Shia,J; Yang,L; Bao,L; Tschopp,J; Gao,J-X; Wang,J; Quigg,R,J; Zhang,J. "Altered thymic selection by overexpressing cellular FLICE inhibitory protein in T cells causes lupus-like syndrome in a BALB/c but not C57BL/6 strain." CELL DEATH AND DIFFERENTIATION. Vol. 17, no. 3. (March 2010.): 522-533.

Yang,L; Qiao,G; Ying,H; Zhang,J; Yin,F. "TCR-induced Akt serine 473 phosphorylation is regulated by protein kinase C-alpha." BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. Vol. 400, no. 1. (September 2010.): 16-20.

Ying,H; Yang,L; Qiao,G; Li,Z; Zhang,L; Yin,F; Xie,D; Zhang,J. "Cutting Edge: CTLA-4-B7 Interaction Suppresses Th17 Cell Differentiation." JOURNAL OF IMMUNOLOGY. Vol. 185, no. 3. (August 2010.): 1375-1378.

Guo,Hui; Qiao,Guilin; Ying,Haiyan; Li,Zhenping; Zhao,Yixia; Liang,Yanran; Yang,Lifen; Lipkowitz,Stanley; Penninger,Josef,M; Langdon,Wallace,Y; Zhang,Jian. "E3 Ubiquitin Ligase Cbl-b Regulates Pten via Nedd4 in T Cells Independently of Its Ubiquitin Ligase Activity." CELL REPORTS. Vol. 1, no. 5. (May 2012.): 472-482.

Qiao,G; Yang,L; Li,Z; Ying,H; Hassen,Y; Yin,F; Zhang,J. "Program death-1 regulates peripheral T cell tolerance via an anergy-independent mechanism." CLINICAL IMMUNOLOGY. Vol. 143, no. 2. (May 2012.): 128-133.

Guo,H; Qiao,G; Ying,H; Li,Z; Zhao,Y; Liang,Y; Yang,L; Lipkowitz,S; Penninger,JM; Langdon,WY; Zhang,J. "E3 Ubiquitin Ligase Cbl-b Regulates Pten via Nedd4 in T Cells Independently of Its Ubiquitin Ligase Activity." CELL REPORTS. Vol. 1, no. 5. (May 2012.): 472-482.

Qiao,Guilin; Zhao,Yixia; Li,Zhenping; Tang,Peter,Q; Langdon,Wallace,Y; Yang,Tianlan; Zhang,Jian. "T Cell Activation Threshold Regulated by E3 Ubiquitin Ligase Cbl-b Determines Fate of Inducible Regulatory T Cells." JOURNAL OF IMMUNOLOGY. Vol. 191, no. 2. (July 2013.): 632-639.

Qiao,G; Zhao,Y; Li,Z; Tang,PQ; Langdon,WY; Yang,T; Zhang,J. "T Cell Activation Threshold Regulated by E3 Ubiquitin Ligase Cbl-b Determines Fate of Inducible Regulatory T Cells." JOURNAL OF IMMUNOLOGY. Vol. 191, no. 2. (July 2013.): 632-639.

Qiao,G; Ying,H; Zhao,Y; Liang,Y; Guo,H; Shen,H; Li,Z; Solway,J; Tao,E; Chiang,YJ; Lipkowitz,S; Penninger,JM; Langdon,WY; Zhang,J. "E3 Ubiquitin Ligase Cbl-b Suppresses Proallergic T Cell Development and Allergic Airway Inflammation." CELL REPORTS. Vol. 6, no. 4. (February 2014.): 709-723.

Veselits,M; Tanaka,A; Lipkowitz,S; O'Neill,S; Sciammas,R; Finnegan,A; Zhang,J; Clark,MR. "Recruitment of Cbl-b to B Cell Antigen Receptor Couples Antigen Recognition to Toll-Like Receptor 9 Activation in Late Endosomes." PLOS ONE. Vol. 9, no. 3. (March 2014.): e89792-.

Zhang, J, Liu, Q, Langdon, WL. "Roles in T Cell Tolerance, Proallergic T Cell Development, and Cancer Immunity." Inflammation and Cell Signaling. Vol. 1, no. 2. (June 2014.): e146-.

Liu,Qingjun; Zhou,Hong; Langdon,Wallace,Y; Zhang,Jian. "E3 ubiquitin ligase Cbl-b in innate and adaptive immunity." CELL CYCLE. Vol. 13, no. 12. (June 2014.): 1875-1884.

Veselits,Margaret; Tanaka,Azusa; Lipkowitz,Stanley; O'Neill,Shannon; Sciammas,Roger; Finnegan,Alison; Zhang,Jian; Clark,Marcus,R. "Recruitment of Cbl-b to B Cell Antigen Receptor Couples Antigen Recognition to Toll-Like Receptor 9 Activation in Late Endosomes." PLOS ONE. Vol. 9, no. 3. (March 2014.): e89792-.

Zhao,Y; Lei,M; Wang,Z; Qiao,G; Yang,T; Zhang,J. "TCR-induced, PKC-theta-mediated NF-kappa B activation is regulated by a caspase-8-caspase-9-caspase-3 cascade." BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. Vol. 450, no. 1. (July 2014.): 526-531.

Zhang, J, Liu, Q, Langdon, WY. "Cbl-b: Roles in T Cell Tolerance, Proallergic T Cell Development, and Cancer Immunity." Inflammation and Cell Signaling. Vol. 1, (January 2014.): 105-.

Zhang,B; Adesanya,TM; Zhang,L; Xie,N; Chen,Z; Fu,M; Zhang,J; Zhang,J; Tan,T; Kilic,A; Li,Z; Zhu,H; Xie,X. "Delivery of Placenta-Derived Mesenchymal Stem Cells Ameliorates Ischemia Induced Limb Injury by Immunomodulation." CELLULAR PHYSIOLOGY AND BIOCHEMISTRY. Vol. 34, no. 6. (January 2014.): 1998-2006.

Liu,Q; Zhou,H; Langdon,WY; Zhang,J. "E3 ubiquitin ligase Cbl-b in innate and adaptive immunity." CELL CYCLE. Vol. 13, no. 12. (June 2014.): 1875-1884.

Qiao,Guilin; Ying,Haiyan; Zhao,Yixia; Liang,Yanran; Guo,Hui; Shen,Huifeng; Li,Zhenping; Solway,Julian; Tao,Enxiang; Chiang,Y,Jeffrey; Lipkowitz,Stanley; Penninger,Josef,M; Langdon,Wallace,Y; Zhang,Jian. "E3 Ubiquitin Ligase Cbl-b Suppresses Proallergic T Cell Development and Allergic Airway Inflammation." CELL REPORTS. Vol. 6, no. 4. (February 2014.): 709-723.

Zhao,Y; Guo,H; Qiao,G; Zucker,M; Langdon,WY; Zhang,J. "E3 Ubiquitin Ligase Cbl-b Regulates Thymic-Derived CD4(+)CD25(+) Regulatory T Cell Development by Targeting Foxp3 for Ubiquitination." JOURNAL OF IMMUNOLOGY. Vol. 194, no. 4. (February 2015.): 1639-1645.

Xiao,Y; Qiao,G; Tang,J; Tang,R; Guo,H; Warwar,S; Langdon,WY; Tao,L; Zhang,J. "Protein Tyrosine Phosphatase SHP-1 Modulates T Cell Responses by Controlling Cbl-b Degradation." JOURNAL OF IMMUNOLOGY. Vol. 195, no. 9. (November 2015.): 4218-4227.

Zhao,Yixia; Guo,Hui; Qiao,Guilin; Zucker,Mark; Langdon,Wallace,Y; Zhang,Jian. "E3 Ubiquitin Ligase Cbl-b Regulates Thymic-Derived CD4(+)CD25(+) Regulatory T Cell Development by Targeting Foxp3 for Ubiquitination." JOURNAL OF IMMUNOLOGY. Vol. 194, no. 4. (February 2015.): 1639-1645.

Qiao,G; Yang,L; Li,Z; Williams,JW; Zhang,J. "A77 1726, the active metabolite of leflunomide, attenuates lupus nephritis by promoting the development of regulatory T cells and inhibiting IL-17-producing double negative T cells." CLINICAL IMMUNOLOGY. Vol. 157, no. 2. (April 2015.): 166-174.

Xiao,Yun; Qiao,Guilin; Tang,Juan; Tang,Rong; Guo,Hui; Warwar,Samantha; Langdon,Wallace,Y; Tao,Lijian; Zhang,Jian. "Protein Tyrosine Phosphatase SHP-1 Modulates T Cell Responses by Controlling Cbl-b Degradation." JOURNAL OF IMMUNOLOGY. Vol. 195, no. 9. (November 2015.): 4218-4227.

Xiao, Y, Tang, J, Guo, H, Zhao, Y, Rappleye, C, Rajaram, M, Schlesinger, LS, Tao, L, Brown, GD, Langdon, WY, Li, BT, and Zhang, J. "Targeting CBLB as a potential therapeutic approach for disseminated candidiasis." Nature Medicine. Vol. 22, no. 8. (August 2016.): 906-914.

Xiao, Y, Liu, J, Peng, Y, Xiong, X, Huang, L, Qin, J, Mei, W, Wang, W, Yang, H, ZHANG, J, and Tao, L. "GSTA3 attenuates renal interstitial fibrosis by inhibiting TGF-β-induced tubular epithelial-mesenchymal transition and fibronectin expression." Plos One. Vol. 11, no. 9. (September 2016.): e0160855-.

Yang, L, Qiao, G, Hassan, Y, Li, Z, Zhang, X, Kong, H, Zeng, W, Yin, F, Zhang, J. "Program Death-1 Suppresses Autoimmune Arthritis by Inhibiting Th17 Response." Arch. Immunol. Ther. Exp.. -.

Song, C, He, L, Zhang, J, Ma, H; Yuan, X, Hu, G, Tao, L, Zhang, J, Meng, J. "Fluorofenidone attenuates pulmonary inflammation and fibrosis via inhibiting the activation of NALP3 inflammasome and IL-1β/IL-1R1/MyD88 pathway." J Cell Mol Med.. -.

Zhang, Jian. "E3 Ubiquitin Ligase Cbl-b in Innate and Adaptive Immunity." Cell Cycle. -.

 

Inventions and Patents

Zhang, J (Single Inventor). "Targeting Nedd4 as a Potential Therapeutical Approach for Multiple Sclerosis." NIH. Filed May 2016.

Zhang, J (Single Inventor). "Targeting CBLB as a Potential Therapeutical Approach to Disseminated Candidiasis." NIH. Filed May 2016.

 

Presentations

"Sequestration of CD4-Lck from the TCR complex may elicit T cell unresponsiveness in NOD mice." Presented at First Congress of the Federation of Immunological Societies of Asia-Oceania (FIMSA), Adelaide, AU|AUS. (December 1996)

"p38 MAPK is involved in both TCR- and CD28-signaling pathways in murine primary T cells." Presented at Keystone Symposia-T Lymphocyte Activation, Differentiation, and Death, Keystone, CO, US|USA. (January 1998)

"CD28 costimulation corrects defective activation of MAPKs and transcription factors AP-1, NF-AT in thymocytes from nonobese diabetic mice." Presented at Canadian Diabetes Association (CDA) Professional Conference and Annual Meetings, Calgary, CA|CAN. (October 1998)

"Caspases mediate T cell proliferation via the regulation of cell cycle progression." Presented at 11th International Congress of Immunology, Stockholm, SE|SWE. (July 2001)

"Cbl-b: A major player in T cell costimulation." Presented at Invited Seminar, Chicago, US|USA. (November 2002)

"Cbl-b: A major player in T cell costimulation." Presented at Invited Seminar, Shanghai, CN|CHN. (March 2003)

"Cbl-b: A major molecule involved in CD28- and CTLA-4-mediated T cell costimulation." Presented at Section of Rheumatology, Department of Medicine, Northwestern University, Chicago, IL, US|USA. (March 2003)

"Cbl-b is a negative regulator of PI3-K and MAP kinases in T cells." Presented at 67th Annual American College of Rheumatology Scientific Meeting, Orlando, US|USA. (October 2003)

"Cbl-b in CD40-mediated B cell activation." Presented at Shanghai Institute of Biological Sciences, Chinese Academy of Sciences, Shanghai, CN|CHN. (March 2004)

"Negative regulation of CD40-mediated B cell activation by E3 ubiquitin ligase Cbl-b." Presented at Experimental Biology 2005, San Diego, US|USA. (April 2005)

"T cell activation: Regulation of Cbl-b expression by CD28 and CTLA-4." Presented at Shanghai Institute of Biological Sciences, Chinese Academy of Sciences, Shanghai, CN|CHN. (July 2005)

"Cellular FLICE inhibitory protein: Role in autoimmunity." Presented at Department of Immunology & Microbiology, Northwestern University, Chicago, IL, US|USA. (September 2006)

"Cbl-b negatively regulates antigen receptor-induced NF-κB activation via controlling the assembly of PKC-θ/CARMA1/Bcl10/MALT1/IKK signaling complex in T cells." Presented at Keystone Symposia (A1, Lymphocyte Activation and Signaling), Steamboat Springs, CO, US|USA. (January 2006)

"Cellular FLICE inhibitory protein: Role in autoimmunity." Presented at Department of Neurology, Central South University, Changsha, CN|CHN. (April 2007)

"Negative regulation of CD40-mediated B cell responses by E3 ubiquitin ligase Cbl-b." Presented at 94th Annual Meeting of American Association of Immunologists, Miami Beach, FL, US|USA. (May 2007)

"Negative regulation of T helper 2 cell differentiation by E3 ubiquitin ligase Cbl-b." Presented at 13th International Congress of Immunology, Rio de Janeiro, BR|BRA. (August 2007)

"Regulation of Th2 differentiation by E3 ubiquitin ligase Cbl-b." Presented at Committee on Molecular Medicine, The University of Chicago, Chicago, IL, US|USA. (October 2008)

"New pathways and functions regulated by E3 ubiquitin ligase Cbl-b." Presented at 2008 Frontier in Immunology Research Network conference, Florence, IT|ITA. (July 2008)

"New pathways and functions regulated by E3 ubiquitin ligase Cbl-b." Presented at Immunology Seminar Series, The Ohio State University, Columbus, US|USA. (March 2009)

"New pathways and functions regulated by E3 ubiquitin ligase Cbl-b." Presented at Shanghai Institutes of Biological Sciences, Chinese Academy of Sciences, Shanghai, CN|CHN. (June 2009)

"New pathways and functions regulated by E3 ubiquitin ligase Cbl-b." Presented at Department of Microbiology and Immunology, University of Western Ontario, London, ON, CA|CAN. (January 2009)

"Cbl-b suppresses T cell receptor-mediated Akt activation by inhibiting down-regulation of Pten activity via a Nedd4-dependent mechanism." Presented at The 2nd European Congress of Immunology, Berlin, DE|DEU. (September 2009)

"Regulation of T cell activation and differentiation by E3 ubiquitin ligase Cbl-b." Presented at Division of Rheumatology, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, US|USA. (November 2010)

"Regulation of T cell activation and differentiation by E3 ubiquitin ligase Cbl-b." Presented at Department of Biology, George State University, Atlanta, GA, US|USA. (December 2010)

"Cbl-b in T cell activation and differentiation." Presented at Sino-US Joint Symposium on Immunology and Diseases, Changsha, CN|CHN. (August 2011)

"Regulation of Pten activation by E3 ubiquitin ligase Cbl-b via Nedd4 in T cells." Presented at Committee on Molecular Medicine, The University of Chicago, Chicago, IL, US|USA. (February 2011)

"Cellular FLICE inhibitory protein in lupus." Presented at Ground Rounds, Division of Rheumatology, Albert Einstein College of Medicine, New York, NY, US|USA. (May 2011)

"Cellular FLICE inhibitory protein in lupus." Presented at Division of Rheumatology, Department of Medicine, SUNY Upstate Medical University, Syracuse, NY, US|USA. (May 2011)

"Cbl-b in T cell activation and differentiation." Presented at Sino-US Joint Symposium on Immunology and Diseases, Changsha, CN|CHN. (August 2011)

"Regulation of T cell activation and differentiation by E3 ubiquitin ligase Cbl-b." Presented at Department of Pathology, University of Nebraska at Omaha, Omaha, NE, US|USA. (January 2011)

"Linking innate immune responses to autoimmunity by E3 ubiquitin ligase Cbl-b." Presented at The 7th International forum on immunology in diabetes, Changsha, CN|CHN. (April 2012)

"Regulation of Inducible CD4+CD25+ regulatory T cells by E3 ubiquitin ligase Cbl-b." Presented at 2012 International Symposium on Epigenetics and Autoimmunity, Changsha, CN|CHN. (October 2012)

"Regulation of T cell activation and differentiation by E3 ubiquitin ligase Cbl-b." Presented at Blood Institute of Wisconsin, Milwaukee, WI, US|USA. (April 2012)

"Regulation of Naturally-Occurring CD4+CD25+ Regulatory T Cell Development by E3 Ubiquitin Ligase Cbl-b." Presented at 100th Annual Meeting of American Association of Immunologists, Honolulu, HI, US|USA. (May 2013)

"Regulation of Th2 responses by E3 ubiquitin ligase Cbl-b." Presented at Department of Microbiology and Immunology, Nanjing Medical University, Nanjing, CN|CHN. (September 2013)

"Regulation of Foxp3 expression by E3 ubiquitin ligase Cbl-b." Presented at Renji Clinical Stem Cell Research Center, Shanghai Jiao Tong University, Shanghai, CN|CHN. (September 2013)

"Regulation of proallergic T cell development and allergic airway inflammation by E3 ubiquitin ligase Cbl-b." Presented at Research Institute at Nationwide Children’s Hospital, Columbus, OH, US|USA. (October 2014)

"Putting a brake on T cells: Regulation of proallergic T cell development and allergic airway inflammation by E3 Ubiquitin Ligase Cbl-b." Presented at Beijing Novo Nordisk Pharmaceuticals Science and Technology Co., Ltd., Beijing, US|USA. (July 2014)

"Putting a brake on T cells: Inhibition of T Cell Activation and Differentiation by E3 Ubiquitin Ligase Cbl-b." Presented at Department of Rheumatology, Xiangya Hospital, Central South University, Changsha, CN|CHN. (July 2014)

"Fungal Recognition Mediated by C-Type Lectin Receptors Dectin-1 and Dectin-2 Is Regulated by E3 Ubiquitin Ligase Cbl-b." Presented at The 4th European Congress of Immunology, Vienna, AT|AUT. (September 2015)

"Regulation of T follicular helper cell development and fungal recognition by E3 ubiquitin ligase Cbl-b." Presented at Department of Nephrology, Xiangya Hospital, Central South University, Changsha, CN|CHN. (July 2015)

"Regulation of host defense against fungal infection by protein ubiquitination." Presented at Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN, US|USA. (August 2015)

"Control of fungal recognition by E3 ubiquitin ligase Cbl-b." Presented at Institute of Molecular Biotechnology of Austrian Academy of Sciences, Vienna, AT|AUT. (September 2015)

"Control of fungal recognition by E3 ubiquitin ligase Cbl-b." Presented at Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, University of Illinois at Chicago, Chicago, IL, US|USA. (November 2015)

"Anti-Fungal Innate Immune Responses Mediated by C-Type Lectin Receptors Dectin-1 and Dectin-2 Is Regulated by E3 Ubiquitin Ligase Cbl-b." Presented at Keystone Symposia: NF-κB and MAP kinase signaling in inflammation, Whistler, BC, CA|CAN. (March 2016)

"Regulation of innate and adaptive immune responses by E3 ubiquitin ligase Cbl-b." Presented at Clinical Immunology Series, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, US|USA. (May 2016)

"Targeting Cbl-b as a Potential Therapeutic Approach for Disseminated Candidiasis." Presented at The 3rd International Molecular Immunology & Immunogenetics Congress (MIMIC-III), Antalya, TR|TUR. (April 2016)

"Regulation of innate and adaptive immune responses by E3 ubiquitin ligase Cbl-b." Presented at Center for Cancer & Immunology Research, The Children’s Research Institute, Children’s National Health System, Washington DC, US|USA. (June 2016)

"Targeting CBLB as a potential therapeutic approach for disseminated candidiasis." Presented at The Second Xiangya Hospital, Central South University, Changsha, CN|CHN. (August 2016)

"Regulation of innate and adaptive immune responses by E3 ubiquitin ligase Cbl-b." Presented at Department of Pediatrics, Duke University, Durham, NC, US|USA. (August 2016)

"Regulation of innate and adaptive immune responses by E3 ubiquitin ligase Cbl-b." Presented at Pediatrics Institute, Cleveland Clinic, Cleveland, OH, US|USA. (August 2016)

 

Professional Activities

present Co-Organizer. Sino-US Joint Symposium on Immunology and Diseases.
 

Unpublished Works

Nuro-Gyina, PK, Rieser, EL, Granitto, MC, Pei, W, Liu, Y, Lee, PW, ZHANG, J, Lovett-Racke, AE, Racke, MK, and Yang, Y. Regulation of effector function of CNS autoreactive CD4 T cells through inhibitory receptors and IL-7Rα. April 2016.

Arcos, J, Sidiki, S, Guo, H, Sasindran, SJ, Scordo, JM, Moliva, JI, Diangelo, L, ZHANG, J, Turner, J, and Torrelles, JB. Mycobacterium tuberculosis cell wall released fragments by the action of the human lung mucosa modulate macrophages to control the infection in an IL-10 dependent manner. February 2016.