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Jian Zhang, PhD

460 W 12th Ave
Columbus, OH 43210

Phone: (614) 292-9447

Email: zhang.3570@osu.edu


Current OSU Appointments

Associate Professor, SBS-Microbial Infectn/Immunity

Associate Professor, Immunology & Rheumatology


Editorial Activities

2014 - present PLOS ONE


1991 - 1993 Postdoctoral Fellowship. Association Fran├žaise contre les Myopathies.
1994 - 1996 Postdoctoral Fellowship. Juvenile Diabetes Research Foundation.
1998 - present Scientific Trainee Award. Canadian Diabetes Association.
2001 - present Association of Immunologists (AAI) Junior Faculty Award. Association of Immunologists (AAI).
2001 - present American Association of Immunologists (AAI) Travel Award to the 11th International Congress of Immunology. American Association of Immunologists (AAI).
2002 - 2003 Arthritis National Research Foundation Fellow. Arthritis National Research Foundation.
2002 - 2007 NIH-Supported Independent Scientist (K02). National Institutes of Health.
2008 - 2011 American Lung Association Career Investigator award (Upper Midwest). American Lung Association.
2012 - 2016 Guest Professorship. Central South University.
2013 - present Association of Immunologists (AAI) Lab Travel Faculty Award. Association of Immunologists (AAI).
2015 - present Association of Immunologists (AAI) Faculty Travel Faculty Award to the 4th European Congress of Immunology. Association of Immunologists (AAI).

Journal Articles

Zhang,J; Cohen-Kaminsky,S; Berrih-Aknin,S. "Macrophage subpopulations in the thymic hyperplasia of patients with myasthenia gravis.." Human antibodies and hybridomas. Vol. 6, no. 4. (January 1995.): 153-160.

Zhang, J, Cohen-Kaminsky, S, Berrih-Aknin, S. "Macrophage subpopulations in the thymic hyperplasia in patients with myasthenia gravis." Hum. Antibodies & Hybridomas. Vol. 6, (June 1995.): 153-.

Zhang,J; Zhou,W,B; Wang,H,L; Guo,S,S. "The effects of T cell subpopulations and recombinant interleukin (IL)-2 on peripheral B cell function in patients with myasthenia gravis.." Human antibodies. Vol. 8, no. 2. (January 1997.): 90-94.

Salojin,K; Zhang,J; Cameron,M; Gill,B; Arreaza,G; Ochi,A; Delovitch,T,L. "Impaired plasma membrane targeting of Grb2-murine son of sevenless (mSOS) complex and differential activation of the Fyn-T cell receptor (TCR)-xi-Cb1 pathway mediate T cell hyporesponsiveness in autoimmune nonobese diabetic mice." JOURNAL OF EXPERIMENTAL MEDICINE. Vol. 186, no. 6. (September 1997.): 887-897.

Salojin,K,V; Zhang,J; Madrenas,J; Delovitch,T,L. "T-cell anergy and altered T-cell receptor signaling: effects on autoimmune disease." IMMUNOLOGY TODAY. Vol. 19, no. 10. (October 1998.): 468-473.

Zhang,J; Salojin,K; Delovitch,T,L. "Sequestration of CD4-associated Lck from the TCR complex may elicit T cell hyporesponsiveness in nonobese diabetic mice." JOURNAL OF IMMUNOLOGY. Vol. 160, no. 3. (February 1998.): 1148-1157.

Zhang,J; Salojin,K; Gao,J,X; Cameron,M; Geisler,C; Delovitch,T,L. "TCR alpha beta chains associate with the plasma membrane independently of CD3 and TCR zeta chains in murine primary T cells." JOURNAL OF IMMUNOLOGY. Vol. 161, no. 6. (September 1998.): 2930-2937.

Zhang,J; Salojin,K,V; Gao,J,X; Cameron,M,J; Bergerot,I; Delovitch,T,L. "p38 mitogen-activated protein kinase mediates signal integration of TCR/CD28 costimulation in primary murine T cells." JOURNAL OF IMMUNOLOGY. Vol. 162, no. 7. (April 1999.): 3819-3829.

Salojin,K,V; Zhang,J; Delovitch,T,L. "TCR and CD28 are coupled via ZAP-70 to the activation of the Vav/Rac-1-/PAK-1/p38 MAPK signaling pathway." JOURNAL OF IMMUNOLOGY. Vol. 163, no. 2. (July 1999.): 844-853.

Salojin,K,V; Zhang,J; Meagher,C; Delovitch,T,L. "ZAP-70 is essential for the T cell antigen receptor-induced plasma membrane targeting of SOS and Vav in T cells." JOURNAL OF BIOLOGICAL CHEMISTRY. Vol. 275, no. 8. (February 2000.): 5966-5975.

Zhang,J; Gao,J,X; Salojin,K; Shao,Q; Grattan,M; Meagher,C; Laird,D,W; Delovitch,T,L. "Regulation of Fas ligand expression during activation-induced cell death in T cells by p38 mitogen-activated protein kinase and c-Jun NH2-terminal kinase." JOURNAL OF EXPERIMENTAL MEDICINE. Vol. 191, no. 6. (March 2000.): 1017-1029.

Gao,J,X; Zhang,J; Awaraji,C; Bhatia,M; Jevnikar,A; Singh,B; Bell,D; Delovitch,T,L. "Preferential proliferation and differentiation of double-positive thymocytes into CD8(+) single-positive thymocytes in a novel cell culture medium." CELLULAR IMMUNOLOGY. Vol. 202, no. 1. (May 2000.): 41-53.

Zhang,J; Mikecz,K; Finnegan,A; Glant,T,T. "Spontaneous thymocyte apoptosis is regulated by a mitochondrion-mediated signaling pathway." JOURNAL OF IMMUNOLOGY. Vol. 165, no. 6. (September 2000.): 2970-2974.

Zhang,J; Bardos,T; Mikecz,K; Finnegan,A; Glant,T,T. "Impaired Fas signaling pathway is involved in defective T cell apoptosis in autoimmune murine arthritis." JOURNAL OF IMMUNOLOGY. Vol. 166, no. 8. (April 2001.): 4981-4986.

Zhang,J; Salojin,K,V; Delovitch,T,L. "CD28 co-stimulation restores T cell responsiveness in NOD mice by overcoming deficiencies in Rac-1/p38 mitogen-activated protein kinase signaling and IL-2 and IL-4 gene transcription." INTERNATIONAL IMMUNOLOGY. Vol. 13, no. 3. (March 2001.): 377-384.

Glant,T,T; Bardos,T; Vermes,C; Chandrasekaran,R; Valdez,J,C; Otto,J,M; Gerard,D; Velins,S; Lovasz,G; Zhang,J; Mikecz,K; Finnegan,A. "Variations in susceptibility to proteoglycan-induced arthritis and spondylitis among C3H substrains of mice - Evidence of genetically acquired resistance to autoimmune disease." ARTHRITIS AND RHEUMATISM. Vol. 44, no. 3. (March 2001.): 682-692.

Vermes,C; Jacobs,J,J; Zhang,J; Firneisz,G; Roebuck,K,A; Glant,T,T. "Shedding of the interleukin-6 (IL-6) receptor (gp80) determines the ability of IL-6 to induce gp130 phosphorylation in human osteoblasts." JOURNAL OF BIOLOGICAL CHEMISTRY. Vol. 277, no. 19. (May 2002.): 16879-16887.

Bardos,T; Czipri,M; Vermes,C; Zhang,J; Mikecz,K; Glant,T,T. "Continuous nasal administration of antigen is critical to maintain tolerance in adoptively transferred autoimmune arthritis in SCID mice." CLINICAL AND EXPERIMENTAL IMMUNOLOGY. Vol. 129, no. 2. (August 2002.): 224-231.

Zhang,J; Bardos,T; Li,D,D; Gal,I; Vermes,C; Xu,J,Y; Mikecz,K; Finnegan,A; Lipkowitz,S; Glant,T,T. "Cutting edge: Regulation of T cell activation threshold by CD28 costimulation through targeting Cbl-b for ubiquitination." JOURNAL OF IMMUNOLOGY. Vol. 169, no. 5. (September 2002.): 2236-2240.

Finnegan,A; Grusby,M,J; Kaplan,C,D; O'Neill,S,K; Eibel,H; Koreny,T; Czipri,M; Mikecz,K; Zhang,J. "IL-4 and IL-12 regulate proteoglycan-induced arthritis through stat-dependent mechanisms." JOURNAL OF IMMUNOLOGY. Vol. 169, no. 6. (September 2002.): 3345-3352.

Bardos,T; Zhang,J; Mikecz,K; David,C,S; Glant,T,T. "Mice lacking endogenous major histocompatibility complex class II develop arthritis resembling psoriatic arthritis at an advanced age." ARTHRITIS AND RHEUMATISM. Vol. 46, no. 9. (September 2002.): 2465-2475.

Bardos,T; Mikecz,K; Finnegan,A; Zhang,J; Glant,T,T. "T and B cell recovery in arthritis adoptively transferred to SCID mice: Antigen-specific activation is required for restoration of autopathogenic CD4(+) Th1 cells in a syngeneic system." JOURNAL OF IMMUNOLOGY. Vol. 168, no. 12. (June 2002.): 6013-6021.

Finnegan,A; Kaplan,C,D; Cao,Y,X; Eibel,H; Glant,T,T; Zhang,J. "Collagen-induced arthritis is exacerbated in IL-10-deficient mice." ARTHRITIS RESEARCH & THERAPY. Vol. 5, no. 1. (January 2003.): R18-R24.

Bardos,T; Czipri,M; Vermes,C; Finnegan,A; Mikecz,K; Zhang,J. "CD4(+)CD25(+) immunoregulatory T cells may not be involved in controlling autoimmune arthritis." ARTHRITIS RESEARCH & THERAPY. Vol. 5, no. 2. (January 2003.): R106-R113.

Zhang,J,A; Bardos,T; Shao,Q; Tschopp,J; Mikecz,K; Glant,T,T; Finnegan,A. "IL-4 potentiates activated T cell apoptosis via an IL-2-dependent-mechanism." JOURNAL OF IMMUNOLOGY. Vol. 170, no. 7. (April 2003.): 3495-3503.

Arreaza,G; Salojin,K; Yang,W; Zhang,J; Gill,B; Mi,Q,S; Gao,J,X; Meagher,C; Cameron,M; Delovitch,T,L. "Deficient activation and resistance to activation-induced apoptosis of CD8(+) T cells is associated with defective peripheral tolerance in nonobese diabetic mice." CLINICAL IMMUNOLOGY. Vol. 107, no. 2. (May 2003.): 103-115.

Zhang,J. "Ubiquitin ligases in T cell activation and autoimmunity." CLINICAL IMMUNOLOGY. Vol. 111, no. 3. (June 2004.): 234-240.

Li,D,D; Gal,I; Vermes,C; Alegre,M,L; Chong,A,SF; Chen,L,P; Shao,Q; Adarichev,V; Xu,X,M; Koreny,T; Mikecz,K; Finnegan,A; Glant,T,T; Zhang,J. "Cutting edge: Cbl-b: One of the key molecules tuning CD28- and CTLA-4-Mediated T cell costimulation." JOURNAL OF IMMUNOLOGY. Vol. 173, no. 12. (December 2004.): 7135-7139.

Glant,T,T; Adarichev,V,A; Nesterovitch,A,B; Szanto,S; Oswald,J,P; Jacobs,J,J; Firneisz,G; Zhang,J; Finnegan,A; Mikecz,K. "Disease-associated qualitative and quantitative trait loci in proteoglycan-induced arthritis and collagen-induced arthritis." AMERICAN JOURNAL OF THE MEDICAL SCIENCES. Vol. 327, no. 4. (April 2004.): 188-195.

Zhang,Jian; Xu,Xuemei; Liu,Yong. "Activation-induced cell death in T cells and autoimmunity.." Cellular & molecular immunology. Vol. 1, no. 3. (June 2004.): 186-192.

Zheng,X,C; Gao,J,X; Chang,X; Wang,Y; Liu,Y; Wen,J; Zhang,H,M; Zhang,J; Liu,Y; Zheng,P. "B7-CD28 interaction promotes proliferation and survival but suppresses differentiation of CD4-CD8-T cells in the thymus." JOURNAL OF IMMUNOLOGY. Vol. 173, no. 4. (August 2004.): 2253-2261.

Chang,Xing; Chen,Li; Wen,Jing; Godfrey,Virginia,L; Qiao,Guilin; Hussien,Yassir; Zhang,Jian; Gao,Jian-Xin. "Foxp3 controls autoreactive T cell activation through transcriptional regulation of early growth response genes and E3 ubiquitin ligase genes, independently of thymic selection." CLINICAL IMMUNOLOGY. Vol. 121, no. 3. (December 2006.): 274-285.

Qiao,Guilin; Lei,Minxiang; Li,Zhenping; Sun,Yonglian; Minto,Andrew; Fu,Yang-Xin; Ying,Haiyan; Quigg,Richard,J; Zhang,Jian. "Negative regulation of CD40-mediated B cell responses by E3 ubiquitin ligase casitas-B-lineage lymphoma protein-B." JOURNAL OF IMMUNOLOGY. Vol. 179, no. 7. (October 2007.): 4473-4479.

Qiao,Guilin; Li,Zhenping; Molinero,Luciana; Alegre,Maria-Luisa; Ying,Haiyan; Sun,Zuoming; Penninger,Josef,M; Zhang,Jian. "T-Cell receptor-induced NF-kappa B activation is negatively regulated by E3 ubiquitin ligase Cbl-b." MOLECULAR AND CELLULAR BIOLOGY. Vol. 28, no. 7. (April 2008.): 2470-2480.

Bao,Lihua; Haas,Mark; Pippin,Jeffrey; Wang,Ying; Miwa,Takashi; Chang,Anthony; Minto,Andrew,W; Petkova,Miglena; Qiao,Guilin; Song,Wen-Chao; Alpers,Charles,E; Zhang,Jian; Shankland,Stuart,J; Quigg,Richard,J. "Focal and segmental glomerulosclerosis induced in mice lacking decay-accelerating factor in T cells." JOURNAL OF CLINICAL INVESTIGATION. Vol. 119, no. 5. (May 2009.): 1264-1274.

Qiao,G; Li,Z; Minto,A,W; Shia,J; Yang,L; Bao,L; Tschopp,J; Gao,J-X; Wang,J; Quigg,R,J; Zhang,J. "Altered thymic selection by overexpressing cellular FLICE inhibitory protein in T cells causes lupus-like syndrome in a BALB/c but not C57BL/6 strain." CELL DEATH AND DIFFERENTIATION. Vol. 17, no. 3. (March 2010.): 522-533.

Ying,Haiyan; Yang,Lifen; Qiao,Guilin; Li,Zhenping; Zhang,Li; Yin,Fei; Xie,Dong; Zhang,Jian. "Cutting Edge: CTLA-4-B7 Interaction Suppresses Th17 Cell Differentiation." JOURNAL OF IMMUNOLOGY. Vol. 185, no. 3. (August 2010.): 1375-1378.

Yang,Lifen; Qiao,Guilin; Ying,Haiyan; Zhang,Jian; Yin,Fei. "TCR-induced Akt serine 473 phosphorylation is regulated by protein kinase C-alpha." BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. Vol. 400, no. 1. (September 2010.): 16-20.

Guo,Hui; Qiao,Guilin; Ying,Haiyan; Li,Zhenping; Zhao,Yixia; Liang,Yanran; Yang,Lifen; Lipkowitz,Stanley; Penninger,Josef,M; Langdon,Wallace,Y; Zhang,Jian. "E3 Ubiquitin Ligase Cbl-b Regulates Pten via Nedd4 in T Cells Independently of Its Ubiquitin Ligase Activity." CELL REPORTS. Vol. 1, no. 5. (May 2012.): 472-482.

Qiao,Guilin; Yang,Lifen; Li,Zhenping; Ying,Haiyan; Hassen,Yassir; Yin,Fei; Zhang,Jian. "Program death-1 regulates peripheral T cell tolerance via an anergy-independent mechanism." CLINICAL IMMUNOLOGY. Vol. 143, no. 2. (May 2012.): 128-133.

Qiao,Guilin; Zhao,Yixia; Li,Zhenping; Tang,Peter,Q; Langdon,Wallace,Y; Yang,Tianlan; Zhang,Jian. "T Cell Activation Threshold Regulated by E3 Ubiquitin Ligase Cbl-b Determines Fate of Inducible Regulatory T Cells." JOURNAL OF IMMUNOLOGY. Vol. 191, no. 2. (July 2013.): 632-639.

Qiao,Guilin; Ying,Haiyan; Zhao,Yixia; Liang,Yanran; Guo,Hui; Shen,Huifeng; Li,Zhenping; Solway,Julian; Tao,Enxiang; Chiang,Y,Jeffrey; Lipkowitz,Stanley; Penninger,Josef,M; Langdon,Wallace,Y; Zhang,Jian. "E3 Ubiquitin Ligase Cbl-b Suppresses Proallergic T Cell Development and Allergic Airway Inflammation." CELL REPORTS. Vol. 6, no. 4. (February 2014.): 709-723.

Liu,Qingjun; Zhou,Hong; Langdon,Wallace,Y; Zhang,Jian. "E3 ubiquitin ligase Cbl-b in innate and adaptive immunity." CELL CYCLE. Vol. 13, no. 12. (June 2014.): 1875-1884.

Veselits,Margaret; Tanaka,Azusa; Lipkowitz,Stanley; O'Neill,Shannon; Sciammas,Roger; Finnegan,Alison; Zhang,Jian; Clark,Marcus,R. "Recruitment of Cbl-b to B Cell Antigen Receptor Couples Antigen Recognition to Toll-Like Receptor 9 Activation in Late Endosomes." PLOS ONE. Vol. 9, no. 3. (March 2014.): e89792-.

Zhao,Yixia; Lei,Minxiang; Wang,Zhaoyuan; Qiao,Guilin; Yang,Tianlun; Zhang,Jian. "TCR-induced, PKC-theta-mediated NF-kappa B activation is regulated by a caspase-8-caspase-9-caspase-3 cascade." BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. Vol. 450, no. 1. (July 2014.): 526-531.

Zhang,Bo; Adesanya,T,MAyodele; Zhang,Li; Xie,Nanzi; Chen,Zhishui; Fu,Minghuan; Zhang,Jie; Zhang,Jian; Tan,Tao; Kilic,Ahmet; Li,Zhihong; Zhu,Hua; Xie,Xiaoyun. "Delivery of Placenta-Derived Mesenchymal Stem Cells Ameliorates Ischemia Induced Limb Injury by Immunomodulation." CELLULAR PHYSIOLOGY AND BIOCHEMISTRY. Vol. 34, no. 6. (January 2014.): 1998-2006.

Zhang, J, Liu, Q, Langdon, WY. "Cbl-b: Roles in T Cell Tolerance, Proallergic T Cell Development, and Cancer Immunity." Inflammation and Cell Signaling. Vol. 1, (January 2014.): 105-.

Zhao,Yixia; Guo,Hui; Qiao,Guilin; Zucker,Mark; Langdon,Wallace,Y; Zhang,Jian. "E3 Ubiquitin Ligase Cbl-b Regulates Thymic-Derived CD4(+)CD25(+) Regulatory T Cell Development by Targeting Foxp3 for Ubiquitination." JOURNAL OF IMMUNOLOGY. Vol. 194, no. 4. (February 2015.): 1639-1645.

Xiao,Yun; Qiao,Guilin; Tang,Juan; Tang,Rong; Guo,Hui; Warwar,Samantha; Langdon,Wallace,Y; Tao,Lijian; Zhang,Jian. "Protein Tyrosine Phosphatase SHP-1 Modulates T Cell Responses by Controlling Cbl-b Degradation." JOURNAL OF IMMUNOLOGY. Vol. 195, no. 9. (November 2015.): 4218-4227.

Qiao,Guilin; Yang,Lifen; Li,Zhenping; Williams,James,W; Zhang,Jian. "A77 1726, the active metabolite of leflunomide, attenuates lupus nephritis by promoting the development of regulatory T cells and inhibiting IL-17-producing double negative T cells." CLINICAL IMMUNOLOGY. Vol. 157, no. 2. (April 2015.): 166-174.

Zhang, Jian. "E3 Ubiquitin Ligase Cbl-b in Innate and Adaptive Immunity." Cell Cycle. -.