601 Vernon Tharp St
Columbus, OH 43210
Phone: (614) 514-8696
Professor, Veterinary Clinical Sciences
Internal medicine of Large Animals
Mary Kopechek, Undergraduate honors research project. Expression of differentiation markers on bovine alveolar macrophages in relation to bovine respiratory disease. Richard H. Kellogg Scholarship, William C Hauk Scholarship. 2006-2007.
Kathleen O’Conner, Undergraduate research project. Cloning and expression of equine MMP 9. Funded by American Live Stock Insurance company grant to Steven M. Reed. Currently VM IV The Ohio State University.
Melissa Long, Undergraduate student, laboratory externship. May 2008 – June 2009. Bovine alveolar macropahge CD163 mRNA; GenBank accession # GQ184570.
Jackie Delaccio, Undergraduate work-study student externship. Serum and synovial fluid concentrations of erythromycin in horses receiving 1 or 2 grams IV by intravenous regional infusion. Funded by UTenn grant to Gal Kelmer DVM (faculty, Koret School of Veterinary Medicine, Israel). M. haemolamae transplacental transmission in alpacas; performed most of the laboratory work (PCR based detection, IFA analysis of M haemolamae specific serum and colostral antibodies). Funded by Morris Animal Foundation grant to J Lakritz. Supervised by Dr. Antoinette E Marsh.
Nicholas Werle, Veterinary student; work study internship. Bovine neutrophil granule haptoglobin is only found in complex with MMP 9. Spring 2011-2012. HPLC of serum florfenicol and alpacas and Llamas. Publication of results in Research in Veterinary Science 2013; Partially funded by gift from the Pennsylvania Llama and Alpaca Association;
Amelia Nyhart, Pre-Veterinary Animal Sciences major. Laboratory assistant in training, summer 2011-2012. Analyzed concentration versus time data of serum florfenicol concentrations by non-compartmental statistical analysis (WinNonlin version 5.2 (Admitted to The Ohio State University College of Veterinary Medicine Class of 2016
Pharmacology of Large Animals
I am a graduate Veterinarian (1987) with post-doctoral training in large animal medicine and surgery (Academic internship and residency) that pursued advanced research training in an NIH funded basic research laboratory. I received my doctoral degree in 1997, and obtained my first academic appointment in 1998. I have been in academic clinical medicine for my entire career (1998-2014). I am board certified in Veterinary Internal Medicine of Large Animals (1997), and recently completed the requirements for board certificaiton in Veterinary Clinical Pharmacology (2014).
My clinical appointment is currently 50% clinical duties, with a 50% administrative, teaching and research appointment. The research I am pursuing involves lung inflammation, bovine respiratory disease and pharmacologic modulation of inflammation. My laboratory has studied biomarkers of neutrophil activation and developed assays to monitor neutrophil biomarkers in cattle with respiratory and other inflammation.
|2013 - present||Caroline Lodge-Stark, The Ohio State University.|
|2014 - present||Joe Lozier, The Ohio State University. Graduated 2014.|
|2014 - present||Caitlin Jablonski, The Ohio State University.|
|2015 - present||Evelyn MacKay, The Ohio State University.|
|2015 - present||Grace VanHoy, The Ohio State University.|
|1998 - 2000||Antonio Alvarez, University of Missouri. Graduated 2000. Role of gamma/delta-T cells in Mycobacterial Infection and inflammation|
|1999 - 2002||Hosam Al-Tamimi, University of Missouri. Effect of nitric oxide donors on thermoregulation and performance of rats and cattle experiencing fescue toxicosis during heat stress|
|2000 - 2002||Jefrey Chakwenya, University of Missouri. Potentiated sulfonamides in Veterinary medicine|
|2002 - 2004||Gagan Gupta, University of Missouri. Expression of recombinant S. neurona SAG1 gene in baculovirus expression system: characterization and functional evaluation|
|2002 - 2004||Aliya Wilson, University of Missouri. Stage specific detection and characterization of enolase by Sarcocystis neurona.|
|2004||Zhihong Zhang, The Ohio State University. Pharmacokinetics, in vitro absorption and metabolism of perillyl alcohol, a chemopreventative and chemotherapeutic agent|
|2003 - 2005||Claire Whitehead, The Ohio State University. Effect of supplemental Vitamin D on serum 25-OH Vitamin D in alpaca dams and their crias|
|2000 - 2006||Masie Dawes, University of Missouri. Effect of colostral lactoferrin on neonatal immune function.|
|2003 - 2006||Sylvan Nichols, The Ohio State University. Graduated 2006. Theloscopic methods of surgical teat injury in cows: experimental wound model to assess healing of wounds|
|2004 - 2006||Daniel Linden, The Ohio State University. Use of organic Zinc in diets of South American camelids, llamas (Lama glama), alpacas (Lama pacos)|
|2006||Hyunjoong Cho, The Ohio State University. Simultaneous determination of flow stress and friction using finite element analysis|
|2005 - 2007||Christopher Premanandan, The Ohio State University. Graduated 2007. Interaction of Bacillus Anthracis with macrophages|
|2005 - 2007||Christina Robinson, The Ohio State University. Graduated 2007. Matrix metalloproteinases in the equine central nervous system : use of computed tomography of the equine skull and brain|
|2006 - 2007||MaryBeth Kopechek, The Ohio State University. Graduated 2008.|
|2005 - 2008||Anita Varga, The Ohio State University. Cardiac Troponin and its use in clinical medicine of cattle|
|2005 - 2008||Christian Gerspach, The Ohio State University. Graduated 2008. Characterization of the expression of the haptoglobin receptor CD163 in bovine alveolar macrophages and the receptor phenotype in CD163+ cells.|
|2006 - 2008||Kari Newman, The Ohio State University. Graduated 2008. Factors affecting lactoferrin concentration at drying off and infection status at calving in dairy cows on an intermittant milking schedule prior to drying off|
|2008||Jongjoo Kim, The Ohio State University. Graduated 2008.|
|2009||Shuo (Dennis), The Ohio State University. Graduated 2009. Peroxisome proliferator activated receptor gamma (PPARg)-independent anti tumor effect of thiazolidinediones.|
|2010||Jesse Martin, The Ohio State University. Graduated 2010. Magnetic field dependent charge transport studies in organic semiconducting materials|
|2010||Veerasamy Sejian, The Ohio State University.|
|2008 - 2011||Charles (Austin), The Ohio State University. Graduated 2011. LPS induced inflammation in calves. Serum Hp-MMP 9 complex as an acute phase response protein complex of neutrophils|
|2011||Christopher J, The Ohio State University. Graduated 2011. The role of micro-RNA-181a in acute leukemia: biological, clinical and therapeutic interventions|
|2010 - 2012||Rebecca Pentecost, The Ohio State University. Graduated 2012. Vertical transmission of Mycoplasma Haemolamae in alpaca cria|
|2011 - 2012||Kazuyuki Suzuki, The Ohio State University.|
|2011 - 2012||Carrie Belles, The Ohio State University. Graduated 2012.|
|2011 - 2013||Brandon Forshey, The Ohio State University. Graduated 2013. Embryo production by superovulation and dual siring in alpacas.|
|2012 - 2013||David Pontius, The Ohio State University. Graduated 2013.|
|2011 - 2014||Dr. Amanda, The Ohio State University. Graduated 2014. Effects of Morphine-Lidocaine-Ketamine CRI on post-operative pain in calves undergoing umbilical hernia repair|
|2012 - 2015||Sarah Depenbrock, The Ohio State University. Graduated 2015. Pharmacokinetics of Ampicillin-Sulbactam in Serum and Synovial Fluid Samples Following Regional Intravenous Administration in the Distal Hind Limb of Adult Cattle|
|1987 - present||Doctor of Veterinary Medicine: California Veterinary Medical Board|
|1992 - present||Doctor of Veterinary Medicine: Florida Board of Veterinary Medicine|
|1997 - present||Diplomate American College of Veterinary Internal Medicine: American College of Veterinary Internal Medicine|
|1999 - present||Doctor of Veterinary Medicine: Missouri Veterinary Medical Board|
|2004 - present||Doctor of Veterinary Medicine: Ohio Veterinary Medical Licensing Board|
|2014 - present||American College of Veterinary Clinical Pharmacolgy: American College of Veterinary Clinical Pharmacology|
Equine Body Systems and Various Disorders:Anatomy
Acute respiratory distress syndrome in adults
Acute respiratory distress syndrom in early infancy
Atypical Interstitial Pneumonia
Bovine Papular Stomatitis
Disorders of the Upper Respiratory Tract in Food Animals
Global climate change: Enteric methane reduction strategies in livestock
Global warming: Role of livestock
Alterations in Respiratory Function
CHARACTERIZATION OF AN AIRWAY EPITHELIAL-CELL FROM NEONATAL RAT
Anatomy of the lung:Structure and Function correlations
Acute respiratory distress (ARDS) in foals
Erythromycin: Pharmacokinetics, bioavailability,non-antimicrobial activity, and possible mechanisms associated with adverse reactions
The respiratory system of thehorse: selected aspects of the functional anatomy and cell biology of normal equinerespiratory system.
Erythromycin: Clinical uses, kinetics and mechanism of action
Macrolide antibiotics as anti-inflammatory agents: effects onbronchoalveolar lavage cell populations
Non-antimicrobial actions of macrolide antibiotics
Neonatal Passive Transfer of Non-immunoglobulin protein: Lactoferrin’s rolein neonatal immunity
Effects of exogenous nitric oxide on thermoregulatory characteristics of cattle experiencing fescue toxicosis during cyclical heat stress
Metalloproteinases in bovine respiratory disease
Gastrointestinal diseases of South American Camelids
Factors affecting embryo collection and transfer in alpacas
|2011 - present||Enivornmental Stress and amelioration in livestock production.|
|2001 - present||Faculty Performance Award.|
|2002 - present||Pfizer Award for Research Excellence.|
|2013 - present||Inventor recognition. OSU Tech Commercialization and Knowledge Transfer.|
"Evaluation of immune responses in horses immunized using a killed Sarcocystis neurona vaccine.." Veterinary therapeutics : research in applied veterinary medicine. Vol. 5, no. 1. (March 2004.): -.
"Impact of oral meloxicam on circulating physiological biomarkers of stress and inflammation in beef steers after long-distance transportation." Journal of Animal Science. Vol. 92, no. 2. (February 2014.): -.
ELISA FOR HAPTOGLOBIN-MATRIX METALLOPROTEINASE 9 COMPLEX AS A DIAGNOSTIC TEST FOR CONDITIONS INCLUDING ACUTE INFLAMMATION
Elisa for Haptoglobin-Matrix Metalloproteinase 9 Complex as a Diagnostic Test for Conditions Including Acute Inflammation
Impact of oral meloxicam on circulating physiological parameters in beef steers after long distance transportation.
Serum neutrophil haptoglobin-matrix metalloproteinase 9 (Hp-MMP 9) responses in calves following a single Intravenous dose of Lipopolysaccharide.