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Irina Artsimovitch, PhD


318 W 12th Ave
Columbus, OH 43210

Phone: (614) 292-6777

Email: artsimovitch.1@osu.edu

 

Current OSU Appointment

Professor, Microbiology Admin

 

Advising Narrative

Publications Artsimovitch, I., Vassylyeva, M.N., Svetlov, D., Svetlov, V., Perederina, A., Igarashi, N., Matsugaki, N., Wakatsuki, S., Tahirov, T. & Vassylyev, D.G. (2005). Allosteric modulation of the RNA polymerase catalytic reaction is an essential component of transcription control by rifamycins. Cell 122: 351-63.Presentations at scientific meetings Svetlov, D. & Artsimovitch, I. 2006 Denman Symposium, Columbus, OH. The molecular basis for differential sensitivity of bacteria to rifamycins. Poster presentation. Presentations at scientific meetings Lange, A. & Artsimovitch, I. 2005 Denman Symposium, Columbus, OH. Analysis of interactions between E. coli virulence regulator RfaH and its target DNA site. Lange, A. & Artsimovitch, I. 2006 Denman Symposium, Columbus, OH. Dissection of the enterobacterial virulence regulatory site ops by saturating random mutagenesis. Poster presentation.Awards Received a third prize at 2006 Denman Symposium (Biological Sciences)Received 2006 ASM Undergraduate Research Scholarship.

Chapters in Books

Artsimovitch, Irina. "Control of transcription termination and antitermination." In The Bacterial Chromosome. Edited by N. P. Higgins. 311-326. Washington, DC: American Society for Microbiology, January 2005.

 

Degrees

1990 M.S., Moscow State University

1996 Ph.D., University of Tennessee

 

Editorial Activities

2002 - present Biochemistry, Journal of Bacteriology, Journal of Biological Chemistry, Journal of Molecular Biology, Nucleic Acids Research, Proteins
2003 - present Biochimie, Bioinformatics, Genes & Development
2005 - present Molecular Microbiology, Nature Structural & Molecular Biology, PNAS
2006 - present Drug Discovery Today, PLoS Biology, The FEBS Journal, Trends in Microbiology
2007 - present Journal of Biology, Methods, Nature, EMBO Journal, EMBO reports
 

Journal Articles

Artsimovitch, I., Murakami, K., Ishihama, A. & Howe, M.M.*. "Transcription activation by the bacteriophage Mu Mor protein requires the C-terminal regions of both alpha and sigma70 subunits of Escherichia coli RNA polymerase.." J Biol Chem. Vol. 271, (January 1996.): 32343-32348.

Artsimovitch, I., Kahmeyer-Gabbe, M. & Howe, M.M.*. "Distortion in the spacer region of Pm during activation of middle transcription of phage Mu.." Proc Natl Acad Sci U S A. Vol. 93, (January 1996.): 9408-9413.

Artsimovitch, I. & Howe, M.M.*. "Transcription activation by the bacteriophage Mu Mor protein: Analysis of promoter mutations in Pm identifies a new region required for promoter function." Nucleic Acids Res. Vol. 24, (January 1996.): 450-457.

Mooney, R.A., Artsimovitch, I. & Landick, R.*. "Information processing by RNA polymerase: Recognition of regulatory signals during RNA chain elongation (invited review).." J Bacteriol. Vol. 180, (January 1998.): 3265-3275.

Artsimovitch, I. & Landick, R.*. "Interaction of a nascent RNA structure with RNA polymerase is required for hairpin-dependent transcriptional pausing but not for transcript release.." Genes Dev. Vol. 12, (January 1998.): 3110-3122.

Yin, H., Artsimovitch, I., Landick, R. & Gelles, J.*. "Nonequilibrium mechanism of transcription termination from observations of single RNA polymerase molecules.." Proc Natl Acad Sci U S A. Vol. 96, (January 1999.): 13124-13129.

Pan, T.,* Artsimovitch, I., Fang, X.W., Landick, R. & Sosnick, T.R.*. "Folding of a large ribozyme during transcription and the effect of the elongation factor NusA.." Proc Natl Acad Sci U S A. Vol. 96, (January 1999.): 9545-9550.

Anthony, L.C., Artsimovitch, I., Svetlov, V., Landick, R. & Burgess, R.R.*. "Rapid purification of His6-tagged Bacillus subtilis core RNA polymerase.." Protein Expr Purif. Vol. 19, (January 2000.): 350-354.

Artsimovitch, Irina*; Svetlov, Vladimir; Anthony, Larry; Burgess, Richard R.; Landick, Robert. "RNA polymerases from Bacillus subtilis and Escherichia coli differ in recognition of regulatory signals in vitro.." Journal of Bacteriology. Vol. 182, (January 2000.): 6027-6035.

Artsimovitch, I. & Landick, R.*. "Pausing by bacterial RNA polymerase is mediated by mechanistically distinct classes of signals.." Proc Natl Acad Sci U S A. Vol. 97, (January 2000.): 7090-7095.

Gruber, T.M., Markov, D., Sharp, M.M., Young, B.A., Lu, C.Z., Zhong, H.J., Artsimovitch, I., Geszvain, K.M., Arthur, T.M., Burgess, R.R., Landick, R., Severinov, K. & Gross, C.A.*. "Binding of the initiation factor sigma70 to core RNA polymerase is a multistep process.." Mol Cell. Vol. 8, (January 2001.): 21-31.

Toulokhonov, I., Artsimovitch, I. & Landick, R.*. "Allosteric control of RNA polymerase by a site that contacts nascent RNA hairpins.." Science. Vol. 292, (January 2001.): 730-733.

Yuzenkova, J., Delgado, M., Nechaev, S., Savalia, D., Epshtein, V., Artsimovitch, I., Mooney, R.A., Landick, R., Farias, R.N., Salomon, R. & Severinov, K.*. "Mutations of bacterial RNA polymerase leading to resistance to microcin J25.." J Biol Chem. Vol. 277, (January 2002.): 50867-50875.

Artsimovitch, I. & Landick, R.*. "The transcriptional regulator RfaH stimulates RNA chain synthesis after recruitment to elongation complexes by the exposed nontemplate DNA strand.." Cell. Vol. 109, (January 2002.): 193-203.

Ederth, J., Artsimovitch, I., Isaksson, L.A. & Landick, R.*. "The downstream DNA jaw of bacterial RNA polymerase facilitates both transcriptional initiation and pausing.." J Biol Chem. Vol. 277, (January 2002.): 37456-37463.

Murphy McDaniel, B.A., Grundy, F.J., Artsimovitch, I. & Henkin, T.M.*. "Transcription termination control of the S box system: Direct measurement of S-adenosylmethionine by the leader RNA.." Proc Natl Acad Sci U S A. Vol. 100, (January 2003.): 3083-3088.

Artsimovitch, I., Svetlov, V., Murakami, K.S. & Landick, R.*. "Co-overexpression of Escherichia coli RNA polymerase subunits allows isolation and analysis of mutant enzymes lacking lineage-specific sequence insertions.." J Biol Chem. Vol. 278, (January 2003.): 12344-12355.

Artsimovitch, I., Chu, C., Lynch, A.S. & Landick, R.*. "A new class of bacterial RNA polymerase inhibitor affects nucleotide addition.." Science. Vol. 302, (January 2003.): 650-654.

Perederina, A., Svetlov, V., Vassylyeva, M.N., Tahirov, T.H., Yokoyama, S., Artsimovitch, I. & Vassylyev, D.G.*. "Regulation through the secondary channel-structural framework for ppGpp-DksA synergism during transcription.." Cell. Vol. 118, (January 2004.): 297-309.

Carter, H.D., Svetlov, V. & Artsimovitch, I.*. "Highly divergent RfaH orthologs from pathogenic proteobacteria can substitute for Escherichia coli RfaH both in vivo and in vitro.." J Bacteriol. Vol. 186, (January 2004.): 2829-2840.

Svetlov, V., Vassylyev, D.G. & Artsimovitch, I.*. "Discrimination against deoxyribonucleotide substrates by bacterial RNA polymerase.." J Biol Chem. Vol. 279, (January 2004.): 38087-38090.

Artsimovitch, I., Patlan, V., Sekine, S., Vassylyeva, M.N., Hosaka, T., Ochi, K., Yokoyama, S.* & Vassylyev, D.G.*. "Structural basis for transcription regulation by alarmone ppGpp.." Cell. Vol. 117, (January 2004.): 299-310.

Vicari, D. & Artsimovitch, I.*. "Virulence regulators RfaH and YaeQ do not operate in the same pathway.." Mol Genet Genomics. Vol. 272, (January 2004.): 489-496.

Vassylyeva, M.N., Perederina, A.A., Svetlov, V., Yokoyama, S., Artsimovitch, I. & Vassylyev, D.G.*. "Cloning, expression, purification, crystallization and initial crystallographic analysis of transcription factor DksA from Escherichia coli.." Acta Crystallogr D. Vol. 60, (January 2004.): 1611-1613.

Toulme, F., Mosrin-Huaman, C., Artsimovitch, I. & Rahmouni, A.R.*. "Transcriptional pausing in vivo: A nascent RNA hairpin restricts lateral movements of RNA polymerase in both forward and reverse directions.." J Mol Biol. Vol. 351, (January 2005.): 39-51.

Artsimovitch, I., Vassylyeva, M.N., Svetlov, D., Svetlov, Vl., Perederina, A., Igarashi, N., Matsugaki, N., Wakatsuki, S., Tahirov, T.H. & Vassylyev, D.G.*. "Allosteric modulation of the RNA polymerase catalytic reaction is an essential component of transcription control by rifamycins.." Cell. Vol. 122, (January 2005.): 351-363.

Vassylyev, D.G. & Artsimovitch, I.. (January 2005.): 977-979.

Vassylyev, D.G.*, Svetlov, V., Vassylyeva, M.N., Perederina, A., Igarashi, N., Matsugaki, N., Wakatsuki, S. & Artsimovitch, I.*. "Structural basis for transcription inhibition by tagetitoxin.." Nat Struct Mol Biol. Vol. 12, (January 2005.): 1086-1093.

Symersky, J., Perederina, A., Vassylyeva, M.N., Svetlov, V., Artsimovitch, I. & Vassylyev, D.G.*. "Regulation through the RNA polymerase secondary channel - Structural and functional variability of the coiled-coil transcription factors.." J Biol Chem. Vol. 281, (January 2006.): 1309-1312.

Artsimovitch, I. & Vassylyev D.G.. (January 2006.): 399-404.

Vassylyeva, M.N., Svetlov, V., Klyuyev, S., Devedjiev, Y.D., Artsimovitch, I.* & Vassylyev, D.G.. "Crystallization and preliminary crystallographic analysis of the transcriptional regulator RfaH from Escherichia coli and its complex with ops DNA." Acta Crystallogr F. Vol. 62, (January 2006.): 1027-1030.

Perederina, A., Vassylyeva, M.N., Berezin, I.A., Svetlov, V., Artsimovitch, I. & Vassylyev, D.G.*. "Cloning, expression, purification, crystallization and initial crystallographic analysis of transcription elongation factors GreB from Escherichia coli and Gfh1 from Thermus thermophilus.." Acta Crystallographica F. Vol. 62, (January 2006.): 44-46.

Belogurov, G.A., Vassylyeva, M.N., Svetlov, V., Klyuyev, S., Grishin, N.V., Vassylyev, D.G.* & Artsimovitch, I.*. "Structural basis for converting a general transcription factor into an operon-specific virulence regulator.." Mol Cell. Vol. 26, (January 2007.): 117-129.

Svetlov, V., Belogurov, G.A., Shabrova, E., Vassylyev, D.G. & Artsimovitch, I.*. "Allosteric control of the RNA polymerase by the elongation factor RfaH.." Nucleic Acids Res. Vol. 35, (January 2007.): 5694-5705.

Artsimovith, I. & Vassylyev, D.G.. (January 2007.): 1122-1123.

Vassylyeva, M.N., Svetlov, V., Dearborn, A.D., Klyuyev, S., Artsimovitch, I.*& Vassylyev, D.G.*. "The carboxy-terminal coiled-coil of the RNA polymerase beta'-subunit is the main binding site for Gre factors.." EMBO Rep. Vol. 8, (January 2007.): 1038-1043.

Vassylyev, D.G.*, Vassylyeva, M.N., Zhang, J., Palangat, M., Artsimovitch, I. & Landick, R.. "Structural basis for substrate loading in bacterial RNA polymerase.." Nature. Vol. 448, (January 2007.): 163-168.

Vassylyev, D.G.*, Vassylyeva, M.N., Perederina, A., Tahirov, T.H. & Artsimovitch, I.. "Structural basis for transcription elongation by bacterial RNA polymerase.." Nature. Vol. 448, (January 2007.): 157-162.

Sevostyanova, A., Svetlov, V., Vassylyev, D.G. & Artsimovitch, I.*. "The elongation factor RfaH and the initiation factor sigma bind to the same site on the transcription elongation complex.." Proc Natl Acad Sci U S A. Vol. 105, (January 2008.): 865-870.

Artsimovitch, I.. (January 2008.): 1-3.

Artsimovitch, I.* & Henkin, T.M.*. "In vitro approaches to analysis of transcription termination.." Methods. Vol. 47, (January 2009.): 37-43.

Miropolskaya, N., Artsimovitch, I., Klimasauskas, S., Nikiforov, V. & Kulbachinskiy, A.*. "Allosteric control of catalysis by the F loop of RNA polymerase.." Proc Natl Acad Sci U S A. Vol. 106, (January 2009.): 18942-18947.

Belogurov, G.A., Vassylyeva, M.N., Sevostyanova, A., Appleman, J.R., Xiang, A.X., Lira, R., Webber, S.E., Klyuyev, S., Nudler, E., Artsimovitch, I.* & Vassylyev, D.G.*. "Transcription inactivation through local refolding of the RNA polymerase structure.." Nature. Vol. 457, (January 2009.): 332-335.

Belogurov, G.A., Mooney, R.A., Svetlov, V., Landick, R. & Artsimovitch, I.*. "Functional specialization of transcription elongation factors.." EMBO J. Vol. 28, (January 2009.): 112-122.

Kulaeva, O.I., Gaykalova, D.A., Pestov, N.A., Golovastov, V.V., Vassylyev, D.G., Artsimovitch, I. & Studitsky, V.M.*. "Mechanism of chromatin remodeling and recovery during passage of RNA polymerase II.." Nat Struct Mol Biol. Vol. 16, (January 2009.): 1272-1278.

Belogurov, G.A., Sevostyanova, A., Svetlov, V. & Artsimovitch, I.*. "Functional regions of the N-terminal domain of the antiterminator RfaH." Mol Microbiol. Vol. 76, (January 2010.): 286-301.

Pupov, D., Miropolskaya, N., Sevostyanova, A., Bass, I., Artsimovitch, I.* & Kulbachinskiy, A.*. "Multiple roles of the RNA polymerase β’ SW2 region in transcription initiation, promoter escape, and RNA elongation.." Nucleic Acids Res. (January 2010.): -.

Sevostyanova, A. & Artsimovitch, I.*. "Functional analysis of Thermus thermophilus transcription factor NusG.." Nucleic Acids Res. (January 2010.): -.

Artsimovitch, I.. Vol. 76, (January 2010.): 535-539.

Miropolskaya, N., Nikiforov, V., Klimasauskas, S., Artsimovitch, I.* & Kulbachinskiy, A.*. "Modulation of RNA polymerase activity through trigger loop folding." Transcription. (January 2010.): -.

Artsimovitch I, Svetlov V, Nemetski SM, Epshtein V, Cardozo T & Nudler E. "Tagetitoxin inhibits RNA polymerase through trapping of the trigger loop." J Biol Chem. Vol. 286, (January 2011.): 40395-40400.

Santangelo TJ, Artsimovitch I. "Termination and antitermination: RNA polymerase runs a stop sign." Nat Rev Microbiol. Vol. 9, (January 2011.): 319-329.

Sevostyanova A, Belogurov GA, Mooney RA, Landick R & Artsimovitch I. "The β subunit gate loop Is required for RNA polymerase modification by RfaH and NusG." Mol Cell. Vol. 43, (January 2011.): 253-262.

Blaby-Haas CE, Furman R, Rodionov DA, Artsimovitch I, de Crécy-Lagard V.. "Role of a Zn-independent DksA in Zn homeostasis and stringent response." Mol Microbiol. Vol. 79, (January 2011.): 700-715.

Perdrizet GA, Artsimovitch I, Furman R, Sosnick TR & Pan T. "Transcriptional pausing coordinates folding of the aptamer domain and the expression platform of a riboswitch." Proc Natl Acad Sci U S A. Vol. epub Feb 13, (January 2012.): -.

Furman R, Sevostyanova A & Artsimovitch I. "Transcription initiation factor DksA has diverse effects on RNA chain elongation." Nucleic Acids Res. Vol. epub Dec 30, (January 2012.): -.

Deaconescu AM, Sevostyanova A, Artsimovitch I & Grigorieff N. "NER machinery recruitment by the transcription-repair coupling factor involves unmasking of a conserved intramolecular interface." Proc Natl Acad Sci U S A. Vol. epub Feb 13, (January 2012.): -.

 

Inventions and Patents

Robert C. Landick, Katherine M. Geszvain, Irina Artsimovitch, Innokenti Toulokhonov, Rachel A. Mooney. "Methods to identify agents that bind the flap-tip helix of RNA polymerase." Filed January 2002.

 

Presentations

"Transcriptional pausing in bacteria: mechanism and regulation." Presented at Genomic Sciences Center, Yokohama, JP|JPN. (January 2003)

"Transcript elongation control by proteins from the RfaH tree: apples and oranges." Presented at FASEB Conference on Control of Transcription in Prokaryotes, Saxtons River, VT. (January 2003)

"Transcript elongation control by proteins from the NusG family." Presented at Molecular Genetics of Bacteria and Phage Meeting, Madison, WI. (January 2003)

"Mechanism of RNAP pausing in Bacteria." Presented at Dept. of Biochemistry, Case Western Reserve University, Cleveland, OH. (January 2003)

"Control of RNA chain elongation in bacteria." Presented at Tokyo Institute of Technology, Yokohama, JP|JPN. (January 2003)

"Control of RNA chain elongation in bacteria." Presented at Dept. of Biochemistry, Ohio State University, Columbus, OH. (January 2003)

"Control of RNA chain elongation in bacteria." Presented at Dept. of Biology, Kenyon College, Gambier, OH. (January 2003)

"Control of RNA chain elongation in bacteria." Presented at RIKEN Institute, Harima, JP|JPN. (January 2003)

"Transcription regulation through the RNA polymerase secondary channel." Presented at Molecular Genetics of Bacteria and Phage Meeting, Cold Spring Harbor, NY. (January 2004)

"Structural basis for transcriptional regulation by alarmone ppGpp." Presented at FASEB Conference on Nucleic Acid Enzymes, Saxtons River, VT. (January 2004)

"Regulation through the secondary channel--structural framework for ppGpp-DksA synergism during transcription." Presented at FASEB Conference on Nucleic Acid Enzymes, Saxtons River, VT. (January 2004)

"Molecular mechanism of antitermination by RfaH." Presented at Postinitiation activities of RNA polymerases, Mountain Lake, VA. (January 2004)

"Molecular mecahnism of ppGpp-DksA synergy." Presented at Molecular Genetics of Bacteria and Phage Meeting, Cold Spring Harbor, NY. (January 2004)

"Mechanism for transcriptional control by rifamycins: a revised version." Presented at Dept. of Biochemistry and Molecular Genetics, University of Alabama, Birmingham, AL. (January 2004)

"Discrimination against deoxyribonucleotide substrates by bacterial RNA polymerase." Presented at FASEB Conference on Nucleic Acid Enzymes, Saxtons River, VT. (January 2004)

"Transcription shutdown through the secondary channel." Presented at Dept. of Chemistry, Ohio State University, Columbus, OH. (January 2005)

"Transcription regulation through the secondary channel." Presented at Dept. of Biochemistry, St. Louis University, St. Louis, MO. (January 2005)

"Transcription regulation through the RNAP secondary channel." Presented at Dept. of Microbiology, University of Georgia, Athens, GA. (January 2005)

"Transcription regulation through the RNAP secondary channel." Presented at National Center for Biotechnology Information, NIH, Bethesda, MD. (January 2005)

"Molecular mechanisms of bacterial transcription." Presented at Dept. of Microbiology, Ohio State University, Columbus, OH. (January 2005)

"Structure, function and evolution of NusG-paralog RfaH." Presented at Postinitiation activities of RNA polymerases, Mountain Lake, VA. (January 2006)

"Regulating gene expression through alterations of basic chemistry – Mg-mediated catalysis of RNA synthesis and cleavage by bacterial RNA polymerase.." Presented at Keystone Meeting on Nucleic Acid Enzymes, Taos, NM. (January 2006)

"Mechanism of action of tagetitoxin." Presented at Keystone Meeting on Nucleic Acid Enzymes, Taos, NM. (January 2006)

"Shifting RNA polymerase into overdrive." Presented at Dept. of Biochemistry, Ohio State University, Columbus, OH. (January 2007)

"Shifting RNA polymerase into overdrive." Presented at Dept. of Pharmacology, UMDNJ, Piscataway, NJ. (January 2007)

"Molecular mechanism of RfaH." Presented at Dept. of Medicinal Chemistry, University of Michigan, Ann Arbor, MI. (January 2007)

"Molecular mechanism of RfaH." Presented at FASEB Conference on Control of Transcription in Prokaryotes, Saxtons River, VT. (January 2007)

"Mechanistic and structural insights into operation of transcription regulators from RfaH/NusG family." Presented at FASEB Conference on Control of Transcription in Prokaryotes, Saxtons River, VT. (January 2007)

"Transcription on fast track." Presented at Dept. of Biochemistry, University of Illinois, Urbana-Champaign, IL. (January 2008)

"Tagetitoxin as a conformation-specific inhibitor of bacterial RNA polymerases." Presented at Gordon Research Conference on New Antibacterial Discovery & Development, Lucca, IT|ITA. (January 2008)

"RNA polymerase on fast track." Presented at Dept. of Microbiology and Cell Science, University of Florida, Gainesville, FL. (January 2008)

"RNA polymerase control through the secondary channel." Presented at 8th EMBL Transcription Meeting, Heidelberg, DE|DEU. (January 2008)

"Regulatory targets on bacterial RNA polymerase." Presented at Dept. of Molecular Biology, Moscow State University, Moscow. (January 2008)

"Molecular mechanism of transcription antiterminator RfaH." Presented at MSU Summer Symposium on Transcriptional Regulation and Systems Biology, Lansing, MI. (January 2008)

"Molecular mechanism of the antiterminator RfaH." Presented at FASEB Conference on Nucleic Acid Enzymes, Saxtons River, VT. (January 2008)

"Functional specialization of NusG-like transcription factors." Presented at 14th meeting on post-initiation activities of RNA polymerase, Mountain Lake, VA. (January 2008)

"Evolution of the NusG family of regulators." Presented at Institute of Molecular Genetics, Moscow. (January 2008)

"Creating diversity in transcription elongation control." Presented at Dept. of Biochemistry, Texas A&M University, College Station, TX. (January 2008)

"Control of transcription in bacteria - from cellular factors to antibiotics." Presented at Dept. of Chemistry, Youngstown State University, Youngstown, OH. (January 2008)

"Secondary channel – a prime site for antibiotics." Presented at International Symposium on Antimicrobial Peptides, Saint Malo, FR|FRA. (January 2009)

"RNA polymerase at crossroads." Presented at Dept. of Chemistry and Biochemistry, Denison University, Granville, OH. (January 2009)

"Regulation of transcription through the non-template DNA." Presented at FASEB Conference on Control of Transcription in Prokaryotes, Saxtons River, VT. (January 2009)

"Molecular mechanism of RfaH." Presented at Molecular Genetics of Bacteria and Phage Meeting, Madison, WI. (January 2009)

"Metamorphosis in transcription." Presented at Institute of Cell Biology, University of Bern, Bern, CH|CHE. (January 2009)

"Division of labor between transcription elongation factors." Presented at Rustbelt RNA Meeting, Deer Creek, OH. (January 2009)

"Allosteric modification of RNA polymerase by RfaH." Presented at École Normale Supérieure de Cachan, Paris, FR|FRA. (January 2009)

"RNA polymerase clamps down." Presented at Dept. of Biochemistry and Food Chemistry, Turku, FI|FIN. (January 2010)

"Molecular mechanism of antitermination." Presented at Goldschmidt 2010, Knoxville, TN. (January 2010)

"The mechanism of transcription antitermination by RfaH." Presented at Experimental Biology 2010, Anaheim, CA. (January 2010)

"Evolution of a transcription antitermination mechanism." Presented at Dept. of Microbiology, The Ohio State University, Columbus, OH. (January 2010)

"DksA family of regulators.." Presented at Div. of Microbiology, Imperial College of London, London. (January 2010)

"Antitermination modification of RNAP." Presented at RNAP 2010 Harden Conference, Cambridge. (January 2010)

 

Professional Activities

2004 - present National Science Foundation Prokaryotic Molecular and Cellular Biology Panel, ad-hoc reviewer.
2005 - present National Science Foundation Microbial Systems Biology Panel, ad-hoc reviewer.
2005 - present National Science Foundation, Prokaryotic Molecular and Cellular Biology Panel Member..
2007 - present ERC Starting Grants Programme.
2008 - present NIH Prokaryotic Cellular and Molecular Biology Study Section, ad-hoc member.
2008 - present NIH Drug Discovery and Antimicrobial Resistance Study Section, ad-hoc member.
2009 - present Analysis of the mechanism of antibiotic undergoing clinical trials.. Optimer Inc..
2009 - present NIH Drug Discovery and Antimicrobial Resistance Study Section Member.
2002 - 2003 Defining the mechanism of action of novel antibiotics. Cumbre Inc..
2009 NIH Prokaryotic Cellular and Molecular Biology Study Section, ad-hoc member.
2010 External examiner for a Ph.D. thesis defense.. Manipal University, India.