Deborah Parris, PhD

Current OSU Appointments

Professor, Molecular Genetics Admin

Professor, SBS-Molec Vir, Imm & Med Gen

Degrees

1972	B.S.Biology, Virginia Tech

1975	Ph.D., Virginia Tech, Microbiology (Virology)

Editorial Activities

Ad Hoc Reviewer

PLos Pathogens.

Journal of Virology.

Journal of General Virology.

Journal of Nucleic Acids.

Nucleic Acids Research.

Journal of Molecular Biology.

Journal of Biological Chemistry.

Honors

1972	National Science Foundation Fellowship, Honorable Mention.

1972	National Science Foundation Traineeship.

1976 - 1978

NIH Individual Postdoctoral Fellowship.

1986	Fogarty Senior International Fellowship.

1998	The James Champion Award.

2006	Fellow, AAAS Fellow. Subject: For distinguished contributions in molecular virology, including an understanding of mechanisms of herpes simplex virus DNA replication, and for leadership in promoting cancer research.

2007	Excellence in Research and Teaching Award, School of Biomedical Sciences. College of Medicine. The Ohio State University College of Medicine, Columbus, OH, United States. ($3,000.00)

2011	Sanford Goldston Award. Ohio Cancer Research Associates. Subject: Cancer research

Memberships

October 2011 - present

Chair. NIAID Special Emphasis panel (J1). Special Study Section-Program projects

Peer Reviewed Journal Articles

Jernigan (Parris), D.S. 1969. An attempt to disintegrate rouleaux of epididymal guinea pig spermatozoa in vitro. Virginia J. Acad. Sci. Proc.. Vol. 7: 17-25.

Parris, D.S., Bates, R.C., and Stout, E.R. 1975. Hydroxyurea synchronization of bovine fetal spleen cells. Exptl. Cell Res.. Vol. 96: 422-425.

Parris, D.S. and Bates, R.C. 1976. Effect of bovine parvovirus replication on DNA, RNA, and protein synthesis in S phase cells. Virology. Vol. 73: 72-78.

Jofre, J., Schaffer, P.A., and Parris, D.S. 1977. Genetics of resistance to phosphonoacetic acid in strain KOS of herpes simplex virus type 1. J. Virology. Vol. 23: 833-836.

Parris, D.S. and Bates, R.C. 1978. Synchronization of primary fetal cell cultures with hydroxyurea. Tissue Culture Association Manual. Vol. 4: 745-747.

Parris, D.S., Courtney, R.J. and Schaffer, P.A. 1978. Regulation of herpes simplex virus type 1 DNA synthesis: Temperature shift studies with DNA negative temperature-sensitive mutants. In Oncogenesis and Herpesvirus III, G. de The, W. Henle, and F. Rapp (Eds.): 299-311.

Parris, D.S., Courtney, R.J., and Schaffer, P.A. 1978. Temperature-sensitive mutants of herpes simplex virus type 1 defective in transcriptional and post-transcriptional functions required for viral DNA synthesis. Virology. Vol. 90: 177-186.

Chu, C.-T., Parris, D.S., Dixon, R.A.F., Farber, F.E., and Schaffer, P.A. 1979. Hydroxylamine mutagenesis of HSV DNA and DNA fragments: Introduction of mutations into selected regions of the viral genome. Virology. Vol. 98: 168-181.

Parris, D.S., Dixon, R.A.F., and Schaffer, P.A. 1980. Physical mapping of herpes simplex virus type 1 ts mutants by marker rescue: Correlation of the physical and genetic maps. Virology. Vol. 100: 275-287.

Stoerker, J., Parris, D., Yajima, Y., and Glaser, R. 1981. Pleiotropic expression of Epstein-Barr virus DNA in human epithelial cells. Proc. Natl. Acad. Sci. (USA). Vol. 78: 5852-5855.

Parris, D.S. and Harrington, J.E. 1982. Herpes simplex virus variants resistant to high concentrations of acyclovir exist in clinical isolates. Antimicrob. Agents Chemother. Vol. 22: 71-77.

Parris, D.S., and Glaser, R. 1983. Herpesviruses. In Microbiology: Basic Principles and Clinical Applications. A.L. Barron and N.R. Rose, Eds. Macmillan, New York.

Amundsen, S.K. and Parris, D.S. 1984. Detection of herpes simplex virus intertypic recombinant genomes in infected cell DNA. J. Virol. Methods. Vol. 8: 19-25.

Muller, M.T., Bolles, C.S., and Parris, D.S. 1985. Association of type I DNA topoisomerase with herpes simplex virus. J. Gen. Virol.. Vol. 66: 1565-1574.

Marsden, H.S., Campbell, M.E.M., Haarr, L., Frame, M.C., Parris, D.S., Murphy, M., Hope, R.G., Muller, M.T., and Preston, C.M. 1987. The 65,000 Mr DNA-binding and virion transinducing proteins of herpes simplex virus type 1. J. Virol.. Vol. 61: 2428-2437.

Williams, M.V. and Parris, D.S. 1987. Characterization of a herpes simplex virus type 2 deoxyuridine triphosphate nucleotidohydrolase and mapping of a gene conferring type specificity for the enzyme. Virology. Vol. 156: 282-292.

Gallo, M.L., Jackwood, D.H., Murphy, M., Marsden, H.S., and Parris, D.S. 1988. Purification of the HSV-l 65 kilodalton DNA binding protein: Properties of the protein and evidence of its association with the viral encoded DNA polymerase. J. Virol.. Vol. 62: 2874-2883.

Parris, D.S., Cross, A., Haarr, L., Orr, A., Frame, M.C., Murphy, M., McGeoch, D.J., and Marsden, H.S. 1988. Identification of the gene encoding the 65 kilodalton DNA binding protein of herpes simplex virus type 1. J. Virol.. Vol. 62: 818-825.

Gallo, M.L., Dorsky, D.I., Crumpacker, C.S., and Parris, D.S. 1989. The essential 65-kilodalton DNA-binding protein of herpes simplex virus stimulates the virus-encoded DNA polymerase. J. Virol.. Vol. 63: 5023-5029.

Goodrich, L.D., Rixon, F.J., and Parris, D.S. 1989. Kinetics of expression of the gene encoding the 65 kilodalton DNA binding protein of herpes simplex virus type 1. J. Virol.. Vol. 63: 137-147.

Goodrich, L.D., Schaffer, P.A., Dorsky, D.I., Crumpacker, C.S., and Parris, D.S. 1990. Localization of the herpes simplex virus type I 65 kilodalton DNA binding protein and DNA polymerase in the presence and absence of viral DNA synthesis. J. Virol.. Vol. 64: 5738-5749.

Johnson, P.A., Best, M.G., Friedmann, T., and Parris, D.S. 1991. Isolation of a herpes simplex virus type 1 mutant deleted for the essential UL42 gene and characterization of its null phenotype. J. Virol.. Vol. 65: 700-710.

Monahan, S.J., Barlam, T.F., Crumpacker, C.S., and Parris, D.S. 1993. Two regions of the herpes simplex virus type 1 UL42 protein are required for its functional interaction with the viral DNA polymerase. J. Virol.. Vol. 67: 5922-5931.

Ebert, S.N., Subramanian, D., Shtrom, S.S., Chung, I.K., Parris, D.S., and Muller, M.T. 1994. Association between the p170 form of human topoisomerase II and progeny viral DNA in cells infected with herpes simplex virus type 1. J. Virol.. Vol. 68: 1010-1020.

Reddig, P.J., Grinstead, L.A., Monahan, S.J., Johnson, P.A., and Parris, D.S. 1994. The essential in vivo function of the herpes simplex virus UL42 protein correlates with its ability to stimulate the viral DNA polymerase in vitro. Virology. Vol. 200: 447-456.

Berthomme, H., Monahan, S., Parris, D.S., Jacquemont, B., and Epstein, A. 1995. Cloning, sequencing, and functional characterization of the two subunits of the pseudorabies virus DNA polymerase holoenzyme: Evidence for specificity of interaction. J. Virol.. Vol. 69: 2811-2818.

Henderson, J.O., Ball-Goodrich, L.J., and Parris, D.S. 1998. Structure-function analysis of the herpes simplex virus type 1 deoxyribonuclease: Correlation of nuclease activity in vitro with replication function in viral-infected cells. Virology. Vol. 243: 247-259.

Monahan, S.J., Grinstead, L.A., Olivieri, W., and Parris, D.S. 1998. Interaction between the herpes simplex virus type 1 origin-binding and DNA polymerase accessory proteins. Virology. Vol. 241: 122-130.

Thornton, K.E., Chaudhuri, M., Monahan, S.J., Grinstead, L.A., and Parris, D.S. 2000. Analysis of in vitro activities of herpes simplex virus type 1 UL42 mutant proteins: Correlation with in vivo function. Virology. Vol. 275: 373-390.

Chaudhuri, M., and Parris, D.S. 2002. Evidence against a simple tethering model for the enhancement of herpes simplex virus DNA polymerase processivity by the accessory protein, UL42. J. Virol.. Vol. 76: 10270-10281.

Chaudhuri, Murari; Parris, Deborah S. 2002. Evidence against a simple tethering model for enhancement of herpes simplex virus DNA polymerase processivity by accessory protein UL42. Journal of virology. Vol. 76, no. 20.

Chaudhuri, M., Song, L., and Parris, D.S. 2003. The herpes simplex virus type 1 DNA polymerase processivity factor increases fidelity without altering pre-steady-state rate constants for polymerization or excision. J. Biol. Chem.. Vol. 278: 8996-9004.

Chaudhuri, Murari; Song, Liping; Parris, Deborah S. 2003. The herpes simplex virus type 1 DNA polymerase processivity factor increases fidelity without altering pre-steady-state rate constants for polymerization or excision. The Journal of biological chemistry. Vol. 278, no. 11.

Trego, K.S., and Parris, D.S. 2003. Functional interaction between the herpes simplex virus type 1 polymerase processivity factor and origin-binding proteins: Enhancement of UL9 helicase activity. J. Virol.. Vol. 77: 12646-12659.

Trego, Kelly, S; Parris, Deborah S. 2003. Functional interaction between the herpes simplex virus type 1 polymerase processivity factor and origin-binding proteins: enhancement of UL9 helicase activity. Journal of virology. Vol. 77, no. 23.

Zhu, Y., Trego, K.S., Song, L., and Parris, D.S. 2003. The 3' to 5' exonuclease activity of herpes simplex virus type 1 DNA polymerase modulates its strand displacement activity. J. Virol.. Vol. 77: 10147-10153.

Zhu, Yali; Trego, Kelly, S; Song, Liping; Parris, Deborah S. 2003. 3' to 5' exonuclease activity of herpes simplex virus type 1 DNA polymerase modulates its strand displacement activity. Journal of virology. Vol. 77, no. 18.

Arana, M.E., Song, L., Tanguy Le Gac, N., Parris, D.S., Villani, G., and Boehmer, P.E. 2004. On the role of proofreading exonuclease in bypass of a bulky 1,2d(GpG) cisplatin adduct by the herpes simplex virus-1 DNA polymerase. DNA Repair. Vol. 3: 659-669.

Arana, Mercedes, E; Song, Liping; Tanguy Le Gac, Nicolas; Parris, Deborah, S; Villani, Giuseppe; Boehmer, Paul E. 2004. On the role of proofreading exonuclease in bypass of a 1,2 d(GpG) cisplatin adduct by the herpes simplex virus-1 DNA polymerase. DNA repair. Vol. 3, no. 6.

Song, L., Chaudhuri, M., Knopf, C.W., and Parris, D.S. 2004. Contribution of the 3' to 5' exonuclease activity of herpes simplex virus type 1 DNA polymerase to fidelity of DNA synthesis. J. Biol. Chem.. Vol. 279: 18535-18543.

Song, Liping; Chaudhuri, Murari; Knopf, Charles, W; Parris, Deborah S. 2004. Contribution of the 3'- to 5'-exonuclease activity of herpes simplex virus type 1 DNA polymerase to the fidelity of DNA synthesis. The Journal of biological chemistry. Vol. 279, no. 18.

Trego, K.S., Zhu, Y., and Parris, D.S. 2005. The herpes simplex virus type 1 DNA polymerase processivity factor, UL42, does not alter the catalytic activity of the UL9 origin-binding protein but facilitates its loading onto DNA. Nuc. Acids Res.. Vol. 33: 536-545.

Trego, Kelly, S; Zhu, Yali; Parris, Deborah S. 2005. The herpes simplex virus type 1 DNA polymerase processivity factor, UL42, does not alter the catalytic activity of the UL9 origin-binding protein but facilitates its loading onto DNA. Nucleic acids research. Vol. 33, no. 2.

Hanes, Jeremiah, W; Zhu, Yali; Parris, Deborah, S; Johnson, Kenneth A. 2007. Enzymatic therapeutic index of acyclovir. Viral versus human polymerase gamma specificity. The Journal of biological chemistry. Vol. 282, no. 34.

Zhu, Y., Song, L., Stroud, J., and Parris, D.S. 2008. Mechanisms by which herpes simplex virus DNA polymerase limits translesion synthesis through abasic sites.  DNA Repair.

Zhu Y; Song L; Stroud J; Parris DS. 2008. Mechanisms by which herpes simplex virus DNA polymerase limits translesion synthesis through abasic sites. DNA Repair. Vol. 7, no. 1. (January 1): 95.

Wu, Z., Zhu, Y., Bisaro, D.M., and Parris, D.S. 2009. Herpes simplex virus type 1 suppresses RNA-induced gene silencing in mammalian cells.  Journal of Virology. Vol. 83. : 6652-6663.

Zhu, Y., Stroud, J., Song, L., and Parris, D.S. 2010. Kinetic Approaches to Understanding the Mechanisms of Fidelity of the Herpes Simplex Virus Type 1 DNA Polymerase.  Journal of Nucliec Acids. Vol. 2010. : Article ID 631595, 15 pages, doi:10.4061/2010/631595.

Zhu, Y., Wu, Z., Cardosa, M.C., and Parris, D.S. 2010. Processing of lagging strand intermediates in vitro by herpes simplex virus type 1 DNA polymerase.  Journal of Virology. Vol. 84. : 7459-7472.

Kuchta, A.L., Parikh, H., Zhu, Y., Kellogg, G.E., Parris, D.S., and McVoy, M.A. 2012. Structural modelling and mutagenesis of human cytomegalovirus alkaline nuclease UL98.  Journal of General Virology. Vol. 93. : 130-138.

Zhu, Y., Celebi Cherukuri, N., Jackel, J.N., Wu, Z., Crary, M., Buckley, K.J., Bisaro, D.M., and Parris, D.S. 2012. Characterization of the RNA silencing suppression activity of the Ebola virus VP35 protein in plants and mammalian cells.  Journal of Virology. (Formally Accepted)

Positions

1986	Honorary Research Fellow, University of Glasgow, Department of Virology. Glasgow, United Kingdom.

1979 - 1988

Assistant Professor, The Ohio State University, Department of Medical Microbiology and Immunology. Columbus, OH, United States.

1988 - 1995

Associate Professor, The Ohio State University, Department of Medical Microbiology and Immunology, and. Columbus, OH, United States.