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Deborah Parris, PhD


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333 W Tenth Avenue
Columbus, OH 43210

Phone: (614) 292-0735

Email: parris.1@osu.edu

 

Current OSU Appointment

Faculty Emeritus, SBS-Molec Vir, Imm & Med Gen

 

Advising Narrative

Biological Sciences Biological Sciences

Degrees

1975 Ph.D., Virginia Tech

 

Editorial Activities

present Journal of Virology
present Journal of Molecular Biology
present Journal of Biological Chemistry
present Nucleic Acids Research
present Journal of General Virology
present PLos Pathogens
present Journal of Nucleic Acids
 

Honors

1972 National Science Foundation Traineeship.
1972 National Science Foundation Fellowship, Honorable Mention.
1976 - 1978 NIH Individual Postdoctoral Fellowship.
1986 Fogarty Senior International Fellowship.
1998 The James Champion Award.
2006 AAAS Fellow.
2007 Excellence in Research and Teaching Award, School of Biomedical Sciences. College of Medicine.
2011 Sanford Goldston Award. Ohio Cancer Research Associates.
 

Journal Articles

Jernigan (Parris), D.S. "An attempt to disintegrate rouleaux of epididymal guinea pig spermatozoa in vitro." Virginia J. Acad. Sci. Proc.. Vol. 7, (January 1969.): 17-25.

Parris, D.S., Bates, R.C., and Stout, E.R.. "Hydroxyurea synchronization of bovine fetal spleen cells." Exptl. Cell Res.. Vol. 96, (January 1975.): 422-425.

Parris, D.S. and Bates, R.C. "Effect of bovine parvovirus replication on DNA, RNA, and protein synthesis in S phase cells.." Virology. Vol. 73, (January 1976.): 72-78.

Jofre, J., Schaffer, P.A., and Parris, D.S.. "Genetics of resistance to phosphonoacetic acid in strain KOS of herpes simplex virus type 1.." J. Virology. Vol. 23, (January 1977.): 833-836.

Parris, D.S., Courtney, R.J., and Schaffer, P.A. "Temperature-sensitive mutants of herpes simplex virus type 1 defective in transcriptional and post-transcriptional functions required for viral DNA synthesis.." Virology. Vol. 90, (January 1978.): 177-186.

Parris, D.S., Courtney, R.J. and Schaffer, P.A. "Regulation of herpes simplex virus type 1 DNA synthesis: Temperature shift studies with DNA negative temperature-sensitive mutants.." In Oncogenesis and Herpesvirus III, G. de The, W. Henle, and F. Rapp (Eds.). (January 1978.): 299-311.

Parris, D.S. and Bates, R.C. "Synchronization of primary fetal cell cultures with hydroxyurea.." Tissue Culture Association Manual. Vol. 4, (January 1978.): 745-747.

Chu, C.-T., Parris, D.S., Dixon, R.A.F., Farber, F.E., and Schaffer, P.A. "Hydroxylamine mutagenesis of HSV DNA and DNA fragments: Introduction of mutations into selected regions of the viral genome.." Virology. Vol. 98, (January 1979.): 168-181.

Parris, D.S., Dixon, R.A.F., and Schaffer, P.A. "Physical mapping of herpes simplex virus type 1 ts mutants by marker rescue: Correlation of the physical and genetic maps.." Virology. Vol. 100, (January 1980.): 275-287.

Stoerker, J., Parris, D., Yajima, Y., and Glaser, R.. "Pleiotropic expression of Epstein-Barr virus DNA in human epithelial cells.." Proc. Natl. Acad. Sci. (USA). Vol. 78, (January 1981.): 5852-5855.

Parris, D.S. and Harrington, J.E.. "Herpes simplex virus variants resistant to high concentrations of acyclovir exist in clinical isolates.." Antimicrob. Agents Chemother. Vol. 22, (January 1982.): 71-77.

Parris, D.S., and Glaser, R. "Herpesviruses. In Microbiology: Basic Principles and Clinical Applications." A.L. Barron and N.R. Rose, Eds. Macmillan, New York. (January 1983.): -.

Amundsen, S.K. and Parris, D.S. "Detection of herpes simplex virus intertypic recombinant genomes in infected cell DNA.." J. Virol. Methods. Vol. 8, (January 1984.): 19-25.

Muller, M.T., Bolles, C.S., and Parris, D.S. "Association of type I DNA topoisomerase with herpes simplex virus." J. Gen. Virol.. Vol. 66, (January 1985.): 1565-1574.

Williams, M.V. and Parris, D.S. "Characterization of a herpes simplex virus type 2 deoxyuridine triphosphate nucleotidohydrolase and mapping of a gene conferring type specificity for the enzyme." Virology. Vol. 156, (January 1987.): 282-292.

Marsden, H.S., Campbell, M.E.M., Haarr, L., Frame, M.C., Parris, D.S., Murphy, M., Hope, R.G., Muller, M.T., and Preston, C.M. "The 65,000 Mr DNA-binding and virion transinducing proteins of herpes simplex virus type 1." J. Virol.. Vol. 61, (January 1987.): 2428-2437.

Parris, D.S., Cross, A., Haarr, L., Orr, A., Frame, M.C., Murphy, M., McGeoch, D.J., and Marsden, H.S. "Identification of the gene encoding the 65 kilodalton DNA binding protein of herpes simplex virus type 1." J. Virol.. Vol. 62, (January 1988.): 818-825.

Gallo, M.L., Jackwood, D.H., Murphy, M., Marsden, H.S., and Parris, D.S. "Purification of the HSV-l 65 kilodalton DNA binding protein: Properties of the protein and evidence of its association with the viral encoded DNA polymerase." J. Virol.. Vol. 62, (January 1988.): 2874-2883.

Goodrich, L.D., Rixon, F.J., and Parris, D.S. "Kinetics of expression of the gene encoding the 65 kilodalton DNA binding protein of herpes simplex virus type 1." J. Virol.. Vol. 63, (January 1989.): 137-147.

Gallo, M.L., Dorsky, D.I., Crumpacker, C.S., and Parris, D.S. "The essential 65-kilodalton DNA-binding protein of herpes simplex virus stimulates the virus-encoded DNA polymerase." J. Virol.. Vol. 63, (January 1989.): 5023-5029.

Goodrich, L.D., Schaffer, P.A., Dorsky, D.I., Crumpacker, C.S., and Parris, D.S. "Localization of the herpes simplex virus type I 65 kilodalton DNA binding protein and DNA polymerase in the presence and absence of viral DNA synthesis." J. Virol.. Vol. 64, (January 1990.): 5738-5749.

Johnson, P.A., Best, M.G., Friedmann, T., and Parris, D.S. "Isolation of a herpes simplex virus type 1 mutant deleted for the essential UL42 gene and characterization of its null phenotype." J. Virol.. Vol. 65, (January 1991.): 700-710.

Monahan, S.J., Barlam, T.F., Crumpacker, C.S., and Parris, D.S. "Two regions of the herpes simplex virus type 1 UL42 protein are required for its functional interaction with the viral DNA polymerase." J. Virol.. Vol. 67, (January 1993.): 5922-5931.

Ebert, S.N., Subramanian, D., Shtrom, S.S., Chung, I.K., Parris, D.S., and Muller, M.T. "Association between the p170 form of human topoisomerase II and progeny viral DNA in cells infected with herpes simplex virus type 1." J. Virol.. Vol. 68, (January 1994.): 1010-1020.

Reddig, P.J., Grinstead, L.A., Monahan, S.J., Johnson, P.A., and Parris, D.S. "The essential in vivo function of the herpes simplex virus UL42 protein correlates with its ability to stimulate the viral DNA polymerase in vitro." Virology. Vol. 200, (January 1994.): 447-456.

Berthomme, H., Monahan, S., Parris, D.S., Jacquemont, B., and Epstein, A. "Cloning, sequencing, and functional characterization of the two subunits of the pseudorabies virus DNA polymerase holoenzyme: Evidence for specificity of interaction." J. Virol.. Vol. 69, (January 1995.): 2811-2818.

Henderson, J.O., Ball-Goodrich, L.J., and Parris, D.S. "Structure-function analysis of the herpes simplex virus type 1 deoxyribonuclease: Correlation of nuclease activity in vitro with replication function in viral-infected cells.." Virology. Vol. 243, (January 1998.): 247-259.

Monahan, S.J., Grinstead, L.A., Olivieri, W., and Parris, D.S. "Interaction between the herpes simplex virus type 1 origin-binding and DNA polymerase accessory proteins." Virology. Vol. 241, (January 1998.): 122-130.

Thornton, K.E., Chaudhuri, M., Monahan, S.J., Grinstead, L.A., and Parris, D.S. "Analysis of in vitro activities of herpes simplex virus type 1 UL42 mutant proteins: Correlation with in vivo function." Virology. Vol. 275, (January 2000.): 373-390.

Chaudhuri, Murari; Parris, Deborah S. "Evidence against a simple tethering model for enhancement of herpes simplex virus DNA polymerase processivity by accessory protein UL42.." Journal of virology. Vol. 76, no. 20. (January 2002.): -.

Chaudhuri, M., and Parris, D.S. "Evidence against a simple tethering model for the enhancement of herpes simplex virus DNA polymerase processivity by the accessory protein, UL42." J. Virol.. Vol. 76, (January 2002.): 10270-10281.

Trego, Kelly, S; Parris, Deborah S. "Functional interaction between the herpes simplex virus type 1 polymerase processivity factor and origin-binding proteins: enhancement of UL9 helicase activity.." Journal of virology. Vol. 77, no. 23. (January 2003.): -.

Trego, K.S., and Parris, D.S. "Functional interaction between the herpes simplex virus type 1 polymerase processivity factor and origin-binding proteins: Enhancement of UL9 helicase activity." J. Virol.. Vol. 77, (January 2003.): 12646-12659.

Chaudhuri, Murari; Song, Liping; Parris, Deborah S. "The herpes simplex virus type 1 DNA polymerase processivity factor increases fidelity without altering pre-steady-state rate constants for polymerization or excision.." The Journal of biological chemistry. Vol. 278, no. 11. (January 2003.): -.

Chaudhuri, M., Song, L., and Parris, D.S. "The herpes simplex virus type 1 DNA polymerase processivity factor increases fidelity without altering pre-steady-state rate constants for polymerization or excision." J. Biol. Chem.. Vol. 278, (January 2003.): 8996-9004.

Zhu, Yali; Trego, Kelly, S; Song, Liping; Parris, Deborah S. "3' to 5' exonuclease activity of herpes simplex virus type 1 DNA polymerase modulates its strand displacement activity.." Journal of virology. Vol. 77, no. 18. (January 2003.): -.

Zhu, Y., Trego, K.S., Song, L., and Parris, D.S. "The 3’ to 5’ exonuclease activity of herpes simplex virus type 1 DNA polymerase modulates its strand displacement activity." J. Virol.. Vol. 77, (January 2003.): 10147-10153.

Song, Liping; Chaudhuri, Murari; Knopf, Charles, W; Parris, Deborah S. "Contribution of the 3'- to 5'-exonuclease activity of herpes simplex virus type 1 DNA polymerase to the fidelity of DNA synthesis.." The Journal of biological chemistry. Vol. 279, no. 18. (January 2004.): -.

Song, L., Chaudhuri, M., Knopf, C.W., and Parris, D.S. "Contribution of the 3’ to 5’ exonuclease activity of herpes simplex virus type 1 DNA polymerase to fidelity of DNA synthesis." J. Biol. Chem.. Vol. 279, (January 2004.): 18535-18543.

Arana, Mercedes, E; Song, Liping; Tanguy Le Gac, Nicolas; Parris, Deborah, S; Villani, Giuseppe; Boehmer, Paul E. "On the role of proofreading exonuclease in bypass of a 1,2 d(GpG) cisplatin adduct by the herpes simplex virus-1 DNA polymerase.." DNA repair. Vol. 3, no. 6. (January 2004.): -.

Arana, M.E., Song, L., Tanguy Le Gac, N., Parris, D.S., Villani, G., and Boehmer, P.E. "On the role of proofreading exonuclease in bypass of a bulky 1,2d(GpG) cisplatin adduct by the herpes simplex virus-1 DNA polymerase." DNA Repair. Vol. 3, (January 2004.): 659-669.

Trego, K.S., Zhu, Y., and Parris, D.S. "The herpes simplex virus type 1 DNA polymerase processivity factor, UL42, does not alter the catalytic activity of the UL9 origin-binding protein but facilitates its loading onto DNA." Nuc. Acids Res.. Vol. 33, (January 2005.): 536-545.

Trego, Kelly, S; Zhu, Yali; Parris, Deborah S. "The herpes simplex virus type 1 DNA polymerase processivity factor, UL42, does not alter the catalytic activity of the UL9 origin-binding protein but facilitates its loading onto DNA.." Nucleic acids research. Vol. 33, no. 2. (January 2005.): -.

Hanes, Jeremiah, W; Zhu, Yali; Parris, Deborah, S; Johnson, Kenneth A. "Enzymatic therapeutic index of acyclovir. Viral versus human polymerase gamma specificity.." The Journal of biological chemistry. Vol. 282, no. 34. (January 2007.): -.

Zhu, Y., Song, L., Stroud, J., and Parris, D.S. "Mechanisms by which herpes simplex virus DNA polymerase limits translesion synthesis through abasic sites." DNA Repair. (January 2008.): -.

Zhu Y; Song L; Stroud J; Parris DS. "Mechanisms by which herpes simplex virus DNA polymerase limits translesion synthesis through abasic sites.." DNA Repair. Vol. 7, no. 1. (January 2008.): 95-.

Wu, Z., Zhu, Y., Bisaro, D.M., and Parris, D.S. "Herpes simplex virus type 1 suppresses RNA-induced gene silencing in mammalian cells." Journal of Virology. Vol. 83, (January 2009.): 6652-6663.

Zhu, Y., Wu, Z., Cardosa, M.C., and Parris, D.S. "Processing of lagging strand intermediates in vitro by herpes simplex virus type 1 DNA polymerase." Journal of Virology. Vol. 84, (January 2010.): 7459-7472.

Zhu, Y., Stroud, J., Song, L., and Parris, D.S.. "Kinetic Approaches to Understanding the Mechanisms of Fidelity of the Herpes Simplex Virus Type 1 DNA Polymerase." Journal of Nucliec Acids. Vol. 2010, (January 2010.): Article ID 631595, 15 pages, doi:10.4061/2010/631595-.

Kuchta, A.L., Parikh, H., Zhu, Y., Kellogg, G.E., Parris, D.S., and McVoy, M.A.. "Structural modelling and mutagenesis of human cytomegalovirus alkaline nuclease UL98." Journal of General Virology. Vol. 93, (January 2012.): 130-138.

Zhu, Y., Celebi Cherukuri, N., Jackel, J.N., Wu, Z., Crary, M., Buckley, K.J., Bisaro, D.M., and Parris, D.S.. "Characterization of the RNA silencing suppression activity of the Ebola virus VP35 protein in plants and mammalian cells." Journal of Virology. (January 2012.): -.