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Chad Rappleye, PhD


Staff photo

484 W 12th Ave
540
Columbus, OH 43210

Phone: (614) 247-2718

Email: rappleye.1@osu.edu

 

Current OSU Appointments

Associate Professor, Microbiology Admin

Associate Professor, SBS-Microbial Infectn/Immunity

 

Advising Narrative

Dean's Undergraduate Research Award (2007)Dean's Undergraduate Research Award (2008)Mayers Summer Research Internship (2008)Student Government Academic Enrichment Grant (2008)College of Arts and Sciences Honors Undergraduate Research Scholarship (2008)NIH Intramural Research Training Award (2009)
Dean's Undergraduate Research Award (2007)
College of Arts and Sciences Honors Undergraduate Research Scholarship (2011)

Academic Advising

2007 - present Eric Holbrook, The Ohio State University. Discovery of virulence factors in the extracellular proteome of Histoplasma capsulatum
2008 - present Jessica Edwards, The Ohio State University. Graduated 2006.
2009 - present Mohamed Ali, The Ohio State University. Comprehensive study of the genetic determinants of virulence and fitness of Salmonella typhimurium in gnotobiotic mice
2010 - present Olga Zemska, The Ohio State University. Genes required for intracellular growth of Histoplasma capsulatum
2007 - 2008 Kimberly Roth, The Ohio State University. Graduated 2008. Immune response to primary aerosol infection with Francisella novicida
2007 - 2009 Brian Bell, The Ohio State University. Graduated 2009. Regulation of virulence gene transcripts by the Francisella orphan response regulator PmrA: role of phosphorylation and evidence of MglA/SspA interaction
2009 Jessica Dyszel, The Ohio State University. Graduated 2009. What turtles taught us: phenotypes of Salmonella SdiA in animals
2009 Patrick Reville, The Ohio State University. Graduated 2009. Targeting phosphoinositol 3 kinase gamma in the treatment of cutaneous leishmaniasis caused by Leishmania mexicana
2007 - 2011 Michelle Brooks, The Ohio State University. Graduated 2011. Nucleotide-binding oligomerization domain containing 2 characterization and function during Mycobacterium tuberculosis infection of human macrophages
2007 - 2011 Jessica Spears, The Ohio State University. Graduated 2011. Trypanosoma brucei tRNA editing deaminase: conserved deaminase core, unique deaminase features
2011 Steven Billups, The Ohio State University. Graduated 2011. Gene duplication of a Pax-2/5/8 family transcription factor in Caenorhabditis
 

Chapters in Books

Histoplasma capsulatum

RNAi-based gene silencing using a GFP sentinel system in Histoplasma capsulatum

Agrobacterium-mediated insertional mutagenesis in Histoplasma capsulatum

 

Degrees

1995 B.S., University of Utah

2002 Ph.D., University of California San Diego

 

Journal Articles

 

Presentations

RNA interference in Histoplasma capsulatum demonstrates a role for alpha-(1,3)-glucan

Functional genomic analysis of the fungal pathogen Histoplasma capsulatum

Histoplasma capsulatum alpha-(1,3)-glucan masks beta­glucan recognition by phagocytes

Histoplasma capsulatum alpha-(1,3)-glucan blocks recognition by the murine beta-glucan receptor Dectin-1

Forward genetic screens to identify fungal virulence mechanisms

Identification of secreted virulence factors of Histoplasma capsulatum

Identification and characterization of secreted protein virulence factors in Histoplasma capsulatum

The secreted proteins of Histoplasma capsulatum

Investigation of the anti-oxidant defense system of Histoplasma capsulatum

Molecular genetic manipulation of Histoplasma capsulatum

Investigation of the anti-oxidant defense system of Histoplasma capsulatum

Functional proteomics in Histoplasma capsulatum

Factors promoting the virulence of Histoplasma capsulatum

Virulence factors in the Histoplasma secreted proteome

Candidate virulence factor identification in the secreted proteome of Histoplasma capsulatum

Characterization of novel proteins secreted by Histoplasma capsulatum yeast

Characterization of novel proteins secreted by Histoplasma capsulatum yeast

Alpha-glucan synthase is dispensible for yeast virulence in chemotype I Histoplasma capsulatum

Alpha-glucan synthase is dispensable for virulence in chemotype I Histoplasma capsulatum

Role of Hsp82 in Histoplasma capsulatum pathogenesis

Identification of virulence factors in Histoplasma capsulatum via a novel high-throughput virulence assay.

The role of Histoplasma capsulatum dioxygenase enzymes in virulence and dimorphism

Functional characterization of the secreted proteome of Histoplasma capsulatum

Functional analysis of proteins secreted by the fungal pathogen Histoplasma capsulatum

Histoplasma capsulatum virulence gene discovery via a novel high-throughput macrophage assay

Characterization of an insertional mutagen for Histoplasma capsulatum

Histoplasma factors combating host-derived oxidative stress

Forward and reverse genetic approaches to virulence factor discovery in Histoplasma capsulatum

Extracellular virulence factors of Histoplasma capsulatum

Virulence factor discovery in the Histoplasma secreted proteome

Histoplasma extracellular defenses to host-derived oxidative stress

Dectin-1 avoidance by the fungal pathogen Histoplasma capsulatum

Discovery of genes contributing to Histoplasma capsulatum virulence via a novel high-throughput macrophage assay

Histoplasma capsulatum extracellular defenses to host-derived oxidative stress

Dectin-1 avoidance by chemotype I Histoplasma yeast

 

Professional Activities

2010 - present Microbiology Representative. Major Fair Exploration Program for Undergraduate Students. Columbus, OH.
2011 - present Microbiology Representative. Major Fair Exploration Program for Undergraduate Students. Columbus, OH.
2011 - present Presentation Judge. Denman Undergraduate Research Forum. Columbus, OH.
2011 - present Study Section Member (ad hoc). NIH / NIAID.
2011 - present Study Section Member (ad hoc). American Heart Association.
2011 - present College of Arts and Sciences Open House. College of Arts and Sciences. Columbus, OH.
2011 - present Advisory Committee. Midwest Neglected Infectious Disease Meeting.
2012 - present Study Section Member (ad hoc). American Heart Association.
2012 - present Grant Reviewer (ad hoc). North Carolina Biotechnology Center.
 

Unpublished Works

Extracellular Superoxide Dismutase Protects Histoplasma Yeast Cells From Host-Derived Oxidative Stress