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Benjamin Kopp, MD, FAAP


700 Childrens Dr
Pulmonary Medicine
Columbus, OH 43205

Phone: (614) 722-4766

Email: kopp.29@osu.edu

 

Current OSU Appointments

Assistant Professor, Pediatrics

Assistant Professor, SBS-Microbial Infectn/Immunity

 

Clinical Interest

Pediatric Pumonology

Advising Narrative

Hannah Rinehardt was inducted into the Sphinx Honorary at The Ohio State University, one of the top awards for all undergraduates at OSU based on her work in the laboratory and philanthropic efforts. She also received a Chemistry Scholarship, and an Undergraduate Research Scholar Award, both based on research grants she put in from data generated in the laboratory. Finally she received 4th place at the Denham research forum for a poster entitled "Cystamine activation of the autophagy pathway to aid in the clearance of Burkholderia cenocepacia in human cystic fibrosis macrophages".

Florentina has received an Arts and Sciences Honors Committee $3,000 Undergraduate Research Scholarship based on a research proposal entitled "MAPK-mediated autophagy signaling in human cystic fibrosis macrophages".

Published Works

Our work over the last 5 years has been instrumental in characterizing fundamental host-pathogen interactions for the virulent pathogen Burkholderia cenocepacia with macrophages from patients with cystic fibrosis. We have identified IL-1beta as the primary inflammatory cytokine induced by B. cenocepacia during overwhelming infection as well as the first characterization on human CF macrophage inflammatory responses to B. cenocepacia. Additionally we have identified dysregulated autophagy as a key driver in deficits in host killing of B. cenocepacia, which can be reversed with autophagy stimulating agents such as IFN-γ which also signals proper macrophage killing. I was the lead or co-author for these publications.

a.&emspAssani K, Tazi MF, Amer AO, Kopp BT. IFN-γ stimulates autophagy-mediated clearance of Burkholderia cenocepacia in human cystic fibrosis macrophages. PLoS One. 2014 May 5;9(5):e96681. PMID: 24798083; PMCID: PMC4010498.
b.&emspKopp BT, Abdulrahman BA, Khweek AA, Kumar SB, Akhter A, Montione R, Tazi MF, Caution K, McCoy K, Amer AO. Exaggerated inflammatory responses mediated by Burkholderia cenocepacia in human macrophages derived from Cystic fibrosis patients. Biochem Biophys Res Commun. 2012 Jul 27;424(2):221-7. PMID: 22728038; PMCID: PMC3408781.
c.&emspAbdulrahman BA, Khweek AA, Akhter A, Caution K, Kotrange S, Abdelaziz DH, Newland C, Rosales-Reyes R, Kopp B, McCoy K, Montione R, Schlesinger LS, Gavrilin MA, Wewers MD, Valvano MA, Amer AO. Autophagy stimulation by rapamycin suppresses lung inflammation and infection by Burkholderia cenocepacia in a model of cystic fibrosis. Autophagy. 2011 Nov;7(11):1359-70. PMID: 21997369; PMCID: PMC3359483.
d.&emspKotrange S, Kopp B, Akhter A, Abdelaziz D, Abu Khweek A, Caution K, Abdulrahman B, Wewers MD, McCoy K, Marsh C, Loutet SA, Ortega X, Valvano MA, Amer AO. Burkholderia cenocepacia O polysaccharide chain contributes to caspase-1-dependent IL-1beta production in macrophages. J Leukoc Biol. 2011 Mar;89(3):481-8. PMID: 21178113; PMCID: PMC3040464.

My other major research interest involves risk factors for disease progression in patients with cystic fibrosis. I have identified several factors that serve as the basis for current prospective studies for biomarkers of disease progression. I was the first person to identify secondhand smoke as a risk factor for poor growth in infants with CF. Additionally, I have identified that hospitalized patients with CF have poor light exposure leading to increased depression rates with subsequently prolonged hospital stays.

a. Kopp BT, Sarzynski L, Khalfoun S, Hayes D Jr, Thompson R, Nicholson L, Long F, Castile R, Groner J.
Detrimental effects of secondhand smoke exposure on infants with cystic fibrosis. Pediatr Pulmonol.
2014 Mar 9. PMID: 24610820.
b. Kopp BT, Hayes D Jr, Ratkiewicz M, Baron N, Splaingard M. Light exposure and depression in
hospitalized adult patients with cystic fibrosis. J Affect Disord. 2013 Sep 5;150(2):585-9.
PMID: 23474091.
c. Kopp BT, Wang W, Chisolm DJ, Kelleher KJ, McCoy KS. Inpatient healthcare trends among adult
cystic fibrosis patients in the U.S. Pediatr Pulmonol. 2012 Mar;47(3):245-51. PMID: 21901854:&emsp
PMCID: PMC3805019.
d. Kopp BT, Nicholson L, Paul G, Tobias J, Ramanathan C, Hayes D Jr. Geographic
variations in cystic fibrosis: An analysis of the U.S. CF Foundation Registry.
Pediatr Pulmonol. 2015 Mar 30. doi: 10.1002/ppul.23185. [Epub ahead of print]
PubMed PMID: 25825016.

Finally, we have developed a translational CF research team whereby interdisciplinary, collaborative research projects can flourish. We investigate risk factors in severe disease pathogenesis for CF. I have served as co-author on these publications.

a.&emspHayes D Jr, Kopp BT, Preston TJ, Kirkby S, Tobias JD, Papadimos TJ, Whitson BA. Survival of patients with cystic fibrosis on ECMO: analysis of the Extracorporeal Life Support Organization Registry. Int J Clin Exp Med. 2014 May 15;7(5):1370-2. eCollection 2014. PubMed PMID: 24995097;
b. &emspLimoli DH, Rockel AB, Host KM, Jha A, Kopp BT, Hollis T, Wozniak DJ. Cationic antimicrobial peptides promote microbial mutagenesis and pathoadaptation in chronic infections. PLoS Pathog. 2014 Apr 24;10(4):e1004083. doi: 10.1371/journal.ppat.1004083. PubMed PMID: 24763694;
c. Hayes D Jr, Daniels CJ, Kirkby S, Kopp BT, Nicholson KL, Nance AE, Splaingard ML.
Polysomnographic differences associated with pulmonary hypertension in patients with advanced lung disease due to cystic fibrosis. Lung. 2014 Jun;192(3):413-9. doi: 10.1007/s00408-014-9573-x. Epub 2014 Mar 27. PubMed PMID: 24671311.
d. &emspHayes D Jr, Daniels CJ, Mansour HM, Kopp BT, Yates AR, McCoy KS, Patel AV, Kirkby S. Right heart catheterization measuring central hemodynamics in cystic fibrosis during exercise. Respir Med. 2013 Sep;107(9):1365-9. doi: 10.1016/j.rmed.2013.02.020. Epub 2013 Jul 2. PubMed PMID: 23830093.

Research Funding

I currently have nearly 100% effort covered from competitive grants. Furthermore, 80% of my time and effort will be covered from 2015-20210 based on my NIH K08 (75%) and collaborator role (5%) on Dr. Amal Amer's R01 targeting microRNAs in CF. Other additional funding sources include the CF Foundation, the AAP, and OSU CCTS.

Academic Advising

I currently manage a lab of two research assistants and four undergraduates who are publishing and receiving accolades for their research. I will be looking to add graduate students and fellows in the upcoming years as I progress through my K award.

Biographical

As a physician scientist, I am leveraging unique training experiences to develop a comprehensive approach to improving chronic pediatric lung disease associated with cystic fibrosis (CF) and sickle cell disease (SCD). My approach combines knowledge gained from translational and basic science laboratory discoveries with Epidemiology and health policy to provide a continuum of care for my patients as well as to guide my own research program. I am currently completing a Master's in Public Health to gain the necessary skills to incorporate 'big data' and public policy into a background of research training in the immunobiology of chronic lung disease. Thereby, I can make discoveries on the spectrum from single cells to whole populations. My research laboratory is currently funded through an NIH K08, along with internal and foundation based grants, and focuses on the early development of lung disease in CF and SCD through host-pathogen and host-environmental interactions. Utilizing my training, I educate in both the laboratory, clinical, and public health setting for healthcare providers and the lay public. My teaching is both direct and social-media focused in order to keep up with the changing learning patterns of our newer generations. Finally, through several local, state, and national committee positions I will acquire the leadership skills necessary to take on academic leadership positions in the future. I have demonstrated the ability to promote innovative clinical programs (sickle cell/pulmonary clinic), research programs (early CF lung disease), team science, and public health, all important factors needed to continue to promote the evolution of academic divisions into national leaders.

Research Interest

Cystic fibrosis, autophagy, Burkholderia, Sickle Cell lung disease

Professional Interests Narrative

Dr Kopp is a physician scientist interested in the care and research of patients with cystic fibrosis and sickle cell and their respiratory complications. He is primarily interested in how the immune system controls infection and the subsequent pathology

Academic Advising

2012 - present Kaivon Assani, Nationwide Children’s Hospital.
2013 - present Laura Rust, Nationwide Children’s Hospital. Emergency Medicine Fellow researching quality improvement in handoffs
2014 - present Hannah Rinehardt, The Ohio State University.
2014 - present Florentina Albastroiu, The Ohio State University.
2015 - present Chandra Shrestha, Nationwide Children’s Hospital.
2014 Avish Jain, The Ohio State University. Graduated 0.
2015 Claudia Vicetti, Nationwide Children’s Hospital. Graduated 0. SCV variants in CF patients
2015 Kate Ellery, Nationwide Children’s Hospital. Graduated 0. Smoke exposure impact on CFTR pancreas
2012 - 2015 Princy Ghera, Nationwide Children’s Hospital. Graduated 0. Pulmonary fellow researching RSV replicons to express CFTR in CF patients
2015 Laksh Malik, Nationwide Children’s Hospital. Graduated 0.
 

Licenses

2012 - present Pediatric Pulmonology: Nationwide Children’s Hospital
 

Clinical Services

01/01/2014 Sickle Cell Lung Disease clinic (Sickle cell NCH clinic)

Clinical Trials

PHOTO

 

Conferences

Kopp BT, Wang W, Chisolm D, Kelleher K, McCoy K. "Inpatient health care trends among adult cystic fibrosis patients in the U.S." In AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. (January 2011). unknown-.

Kopp BT, AbdulRahman B, McCoy KS, Amer AO. "Exaggerated inflammatory responses in human cystic fibrosis macrophages during Burkholderia cenocepacia infection." In PEDIATRIC PULMONOLOGY. (January 2011). 260-260.

Kopp BT, Baron N, Splaingard M. "Lighting up depression in cystic fibrosis." In PEDIATRIC PULMONOLOGY. (September 2012). 431-431.

Abdulrahman BA, Abu Khweek A, Caution K, Akhter A, Tazi MF, Kopp BT, Amer AO. "Autophagy stimulation manipulates Burkholderia cenocepacia infection in a cystic fibrosis mouse model." In FASEB JOURNAL. (April 2012). unknown-.

 

Degrees

2006 M.D., The Ohio State University

2017 None Indicated, The Ohio State University

 

Editorial Activities

2012 - present Air and Water Borne Diseases Journal
2013 - present Pediatric Oncall
2013 - present Respiratory Care
2013 - present PLOS One
2014 - present Pediatric Allergy, Immunology, and Pulmonology
2015 - present Journal of Immunology
2015 - present BMC Pulmonary Medicine
2015 - present Pediatric Infectious Disease Journal
2015 - present Lung
 

Honors

2002 Dean's Scholar for Undergraduate Research. Dean's Scholar.
2005 Orr Medicine Scholarship, 2005. ORR.
2006 Pediatric Departmental Award for Excellence. Departmental of Pediatric.
2010 - 2011 Distinguished Clinical Fellow of the Year. Davis Heart/Lung Research Institute.
2010 - 2012 NIH Loan Repayment Award. Loan Payment.
2011 ATS Travel Award. ATS.
2011 Clinical Fellow Poster Competition Winner. NCH.
2012 ATS Travel Award. ATS.
2012 OSUMC Research Day Travel Award. OSU.
2014 - 2016 NIH Loan Repayment Renewal Award. NIH.
2015 - present Columbus' Finest. Central Ohio Cystic Fibrosis Foundation.
2015 - present Leading Physicians of the World. Leading Physicians of the World.
 

Journal Articles

Abdulrahman BA, Abu Khweek A, Akhter A, Caution K, Kotrange S, Abdelaziz DH, Newland C, Rosales-Reyes R, Kopp BT, McCoy K, Montione R, Schlesinger LS, Gavrilin MA, Wewers MD, Valvano MA, Amer AO. "Autophagy stimulation by rapamycin suppresses lung inflammation and infection by Burkholderia cenocepacia in a model of cystic fibrosis." Autophagy. Vol. 7, no. 11. (November 2011.): 1359-1370.

Kotrange S, Kopp BT, Akhter A, Abdelaziz D, Abu Khweek A, Caution K, Abdulrahman B, Wewers M, McCoy K, Marsh C, Loutet SA, Ortega X, Valvano MA, Amer AO. "Burkholderia cenocepacia O polysaccharide chain contributes to caspase-1-dependent IL-1 beta production in macrophages." J Leukoc Biol. Vol. 89, no. 3. (March 2011.): 481-488.

Kopp BT, Pastore MT, Sturm AC, Holtzlander MJ, Westman JA. "A novel exon duplication of the cystic fibrosis transmembrane conductance regulator in a patient presenting with adult-onset recurrent pancreatitis." Pancreas. Vol. 40, no. 5. (July 2011.): 773-777.

Kopp BT, Rosen KL, O'Donovan JC, Sheikh S. "Cardiac fibroma, anomalous pulmonary venous course and persistent pneumonia in a patient with Gorlin syndrome." Pediatr Pulmonol. Vol. 49, no. 1. (November 2012.): e7-e9.

Kopp BT, Wang W, Chisolm DJ, Kelleher KJ, McCoy KS. "Inpatient healthcare trends among adult cystic fibrosis patients in the U.S.." Pediatr Pulmonol. Vol. 47, no. 3. (March 2012.): 245-251.

Kopp BT, Abdulrahman BA, Khweek AA, Kumar SB, AkhterA, Montione, R., Tazi MF, Caution K, McCoy K, Amer AO. "Exaggerated inflammatory responses mediated by Burkholderia cenocepacia in human macrophages derived from Cystic fibrosis patients." Biochem Biophys Res Commun. Vol. 424, no. 2. (July 2012.): 221-227.

Hayes D Jr, Ramanathan C, Kopp BT. "BMPR2 missense mutation p.K230N and pulmonary arterial hypertension." Pediatr Pulmonol. Vol. 49, no. 1. (November 2012.): e5-e6.

Hayes D Jr, Baker PB, Kopp BT, Kirkby S, Galantowicz M, McConnell PI, Astor TL. "Surveillance transbronchial biopsies in infant lung and heart-lung transplant recipients." Pediatr Transplant. Vol. 17, no. 7. (November 2013.): 670-675.

Hayes D Jr, Daniels CJ, Mansour HM, Kopp BT, Yates AR, McCoy KS, Patel AV, Kirkby S. "Right heart catheterization measuring central hemodynamics in cystic fibrosis during exercise.." Respir Med. Vol. 107, no. 9. (September 2013.): 1365-1369.

Meadows JT Jr, Kopp BT, Shook LA, Ballard HO, Hayes Jr D. "Elevated high-sensitivity C-reactive protein in preterm infants with pulmonary colonization with Ureaplasma." J Thorac Dis. Vol. 5, no. 3. (June 2013.): 223-227.

Kopp BT, Hayes D Jr, Ratkiewicz M, Baron N, Splaingard M. "Light exposure and depression in hospitalized adult patients with cystic fibrosis." J Affect Disord. Vol. 150, no. 2. (September 2013.): 585-589.

Kopp BT, Kirkby S, Hayes D Jr, Flanigan KM. "Diabetic myonecrosis in a cystic fibrosis patient." Respir Care. Vol. 58, no. 10. (October 2013.): e123-e125.

Hayes D Jr, Naguib A, Kirkby S, Galantowicz M, McConnell PI, Baker PB, Kopp BT, Lloyd EA, Astor TL. "Comprehensive evaluation of lung allograft function in infants after lung and heart-lung transplantation." J Heart Lung Transplant. Vol. 33, no. 5. (May 2014.): 507-513.

Turner TL, Kopp BT, Paul G, Landgrave LC, Hayes D Jr, Thompson R. "Respiratory syncytial virus: current and emerging treatment options.." Clinicoecon Outcomes Res. Vol. 6, (January 2014.): 217-225.

Assani K, Tazi MF, Amer AO, Kopp BT. "IFN-gamma stimulates autophagy-mediated clearance of Burkholderia cenocepacia in human cystic fibrosis macrophages." PLoS One. Vol. 9, no. 5. (May 2014.): e96681-.

Hayes D Jr, Kopp BT, Preston TJ, Kirkby S, Tobias JD, Papadimos TJ, Whitson BA. "Survival of patients with cystic fibrosis on ECMO: analysis of the Extracorporeal Life Support Organization Registry." Int J Clin Exp Med. Vol. 7, no. 5. (January 2014.): 1370-1372.

Limoli DH, Rockel AB, Host KM, Jha A, Kopp BT, Hollis T, Wozniak DJ. "Cationic antimicrobial peptides promote microbial mutagenesis and pathoadaptation in chronic infections.." PLoS Pathog. Vol. 10, no. 4. (April 2014.): e1004083-.

Hayes D Jr, Daniels CJ, Kirkby S, Kopp BT, Nicholson KL, Nance AE, Splaingard ML. "Polysomnographic differences associated with pulmonary hypertension in patients with advanced lung disease due to cystic fibrosis." Lung. Vol. 192, no. 3. (June 2014.): 413-419.

Hayes D Jr, Kopp BT, Kirkby S, Allen ED, McCoy KS. "Attrition in pediatric pulmonology fellowship." Pediatr Allergy Immunol Pulmonol. Vol. 27, no. 1. (March 2014.): 34-35.

Kopp BT, Sarzynski L, Khalfoun S, Hayes D Jr, Thompson R, Nicholson L, Long F, Castile R, Groner J. "Detrimental effects of secondhand smoke exposure on infants With cystic fibrosis." Pediatr Pulmonol. Vol. 50, no. 1. (January 2015.): 25-34.

Kopp,Benjamin,T; Nicholson,Lisa; Paul,Grace; Tobias,Joseph; Ramanathan,Chandar; Hayes,Don. "Geographic variations in cystic fibrosis: An analysis of the US CF Foundation Registry." PEDIATRIC PULMONOLOGY. Vol. 50, no. 8. (August 2015.): 754-762.

Hayes,Don; Kirkby,Stephen; Whitson,Bryan,A; Black,Sylvester,M; Sheikh,Shahid,I; Tobias,Joseph,D; Mansour,Heidi,M; Kopp,Benjamin,T. "Mortality Risk and Pulmonary Function in Adults With Cystic Fibrosis at Time of Wait Listing for Lung Transplantation." ANNALS OF THORACIC SURGERY. Vol. 100, no. 2. (August 2015.): 474-479.

Hayes,Don; Kopp,Benjamin,T; Tobias,Joseph,D; Woodley,Frederick,W; Mansour,Heidi,M; Tumin,Dmitry; Kirkby,Stephen,E. "Survival in Patients with Advanced Non-cystic Fibrosis Bronchiectasis Versus Cystic Fibrosis on the Waitlist for Lung Transplantation.." Lung. Vol. 193, no. 6. (December 2015.): 933-938.

Kopp,Benjamin,T; Hayes,Don; Ghera,Princy; Patel,Alpa; Kirkby,Stephen; Kowatch,Robert,A; Splaingard,Mark. "Pilot trial of light therapy for depression in hospitalized patients with cystic fibrosis." JOURNAL OF AFFECTIVE DISORDERS. Vol. 189, (January 2016.): 164-168.

Kopp B, Hayes D, Ratkiewicz M, Baron N, Splaingard M.. ""Light exposure and depression in hospitalized adults with cystic fibrosis."." J Affective Disorders 2013. -.

Kopp B, Kirkby S, Hayes D, Flanigan K.. ""Diabetic myonecrosis in cystic fibrosis patient."." Respiratory Care 2013 Jan 29. -.

Kirkby S, Hayes D, Parson J, Wisely C, Kopp BT, McCoy K, Mastronarde J. "Eucapnic voluntary hyperventilation to detect exercise-induced bronchoconstriction in cystic fibrosis." Lung. -.

Kopp BT, Nicholson L, Paul G, Tobias J, Ramanathan C, Hayes D. "Geographic variations in cystic fibrosis: an analysis of the U.S. CF registry." Pediatr Pulmonol. -.

Kopp BT, Groner J, Tobias JD, Whitson BA, Kirkby S, Hayes Jr D. "Cigarette smoking impact on survival after lung transplantation in cystic fibrosis." Exp Clin Transplant. -.

Hayes Jr D, Black S, Tobias J, Kopp B, Kirkby S, Mansour H, Whitson B. "Influence of HLA mismatching on bronchiolitis obliterans syndrome in lung transplantation." Journal of Heart and Lung Transplantation. -.

Kopp BT, Hayes Jr D, Ghera P, Patel A, Kirkby S, Kowatch RA, Splaingard M. "Pilot Trial of Phototherapy for depression in hospitalized patients with cystic fibrosis." Jouranl of Affective Disorders. -.

Hayes D Jr, Kopp BT, Tobias JD, Woodley FW, Mansour HM, Tumin D, Kirkby SE.. "Survival in Patients with Advanced Non-cystic Fibrosis Bronchiectasis Versus Cystic Fibrosis on the Waitlist for Lung Transplantation." Lung. -.

Khalil H, Tazi M, Caution, K, Ahmed A, Kanneganti A, Assani K, Kopp B, and Amer A. "Aging is associated with hypermethylation of autophagy genes." Epigenetics. -.

Hayes D, Kirkby S, Whiton B, Black SM, Sheikh S, Tobias J, Monsour H, Kopp BT. "Mortality risk and pulmonary function in adults with cystic fibrosis at time of wait listing for lung transplantation." Ann Thorac Surg. -.

 

Reference Works

January 2012 Hayes D Jr, Kopp BT, Mansor HM, Kirkby S, Yates AR, McCoy KS, Daniels CJ."Chest" ..
January 2013 Hayes D Jr, Kopp BT, Preston T, Kirkby S, Whitson B."Euro ELSO congress" ..
January 2013 Hayes D Jr, Kopp BT, Preston T, Kirkby S, Mansour H, Whitson B."NACFC" ..
January 2013 Tazi M, Kopp B, Amer A, et al.."Midwest Microbial Pathogenesis Conference" ..
January 2013 Abdulrahman B, Tazi M, Kopp BT, Amer AO."International Burkholderia Cepacia Working Group" ..
November 2013 Assani K, Amer AO, Kopp BT."Midwest Microbial Pathogenesis Conference" ..
January 2014 Woodley F, Machado R, Hayes D, Kopp BT, Kaul A, Di Lorenzo C, Skaggs C, Mousa H."American Thoracic Society" ..
Hayes D, Black S, Kirkby S, Kopp BT, Tobias J, Mansour H, Whitson B."Survival in CF and non-CF bronchiectasis" .

Inventions and Patents

Kopp, BT, and Schlesinger, LS. PI. "COMPOSITIONS AND METHODS FOR INHIBITING THE GROWTH OF MULTI-DRUG RESISTANT BACTERIA." filed 2015, (patent pending), and Application No. 2242-00-004P01

 

Presentations

"Burkholderia Cenocepacia Type 6 Secretion System and LPS are required for IL-1B Production in Macrophages." Presented at Young Investigator's Respiratory Disease Forum,, San Antonio, TX, US|USA. (January 2010)

"A novel exon duplication of the cystic fibrosis transmembrane conductance regulator in a patient presenting with adult onset recurrent pancreatitis.." Presented at North American CF Conference, Baltimore, MD, US|USA. (January 2010)

"Inpatient Health Care Trens among Adult Cystic Fibrosis Patients." Presented at American Thoracic Society Conference, Denver, CO, US|USA. (January 2011)

"Exaggerated Inflammatory Responses in CF Macrophages durning Burkholderia Cenocepacia Infection." Presented at Young Investigatior's Respiratory Disease Forum., Atlanta, GA, US|USA. (January 2011)

"Exaggerated Inflammatory Responses in CF Macrophages during Burkolderia Cenocepacia Infection.." Presented at North American CF Conference, Anaheim, CA, US|USA. (January 2011)

"Lighting up Inpatient Depression in CF." Presented at North American CF Conference., Orlando. (January 2012)

"Excercise-induced Pulmonary Arterial Hypertension and Younf Adult Patients with Cystic Fibrosis." Presented at Chest, . (January 2012)

"Sugar Pains: Noval diabetic myonecrosis in CF patient.." Presented at American Thoracic Society Conference, San Francisco, CA, US|USA. (May 2012)

"Autophagic clearance of Burkholderia cenocepacia." Presented at American Thoracic Society Conference, Philadelphia, PA, US|USA. (May 2013)

"Autophagy stimulation by IFN-γ improves B. cenocepacia clearance in human CF macrophages." Presented at International Burkholderia Cepacia Working Group., . (April 2013)

"Autophagy mediated clearance of Burkholderia cenocepacia in CF." Presented at International Congress on Bacteriology and Infectious Diseases., . (November 2013)

"Vitamin D enhanced autophagic clearance of B. cenocepacia in CF macrophages." Presented at NACFC, . (October 2013)

"Detrimental effects of secondhand smoke exposure on infants with CF.." Presented at North American CF Conference, . (October 2013)

"Burkholderia Species Decrease Oxidative Burst In CF Macrophages." Presented at American Thoracic Society, . (May 2014)

"An intricate link between autophagy, microRNAs, and." Presented at North American Cystic Fibrosis Conference, . (October 2014)

"Regional variations in cystic fibrosis care." Presented at North American Cystic Fibrosis Conference, . (October 2014)

"Pilot Trial of Phototherapy for Depression in Hospitalized CF Patients." Presented at American Thoracic Society, . (May 2015)

"The Care of Respiratory Disorders in Children with Sickle Cell Disease." Presented at American Thoracic Society, Denver, US|USA. (May 2015)

"The effect of secondhand smoke exposure in cystic fibrosis." Presented at American Academy of Pediatrics Tobacco Consortium, chicago. (May 2015)

"Microbiology: Epidemiology and sources of infection." Presented at European Cystic Fibrosis Conference, Brussels, BE|BEL. (June 2015)

"Autophagic clearance of Burkholderia cenocepacia." Presented at European Cystic Fibrosis Conference, BE|BEL. (June 2015)

"The contribution of Burkholderia and macrophages to oxidative killing deficits in cystic fibrosis." Presented at International Burkholderia Cepacia Working Group, . (April 2015)

"AR-13 as a potential new therapeutic for reducing antibiotic resistant bacterial burden in cystic fibrosis.." Presented at North American Cystic Fibrosis Conference, Phoenix. (October 2015)

 

Professional Activities

present Fellow Leadership Program.
present NCH Alumni Weekend Key Physician Leader.
present Pulmonary Division Code of Cooperation Committee.
2009 - present Graduate Medical Education Committee.
2010 - present Cystic Fibrosis Adult Transition Committee.
2011 - present Operational Excellence Committee.
2012 - present Cystic Fibrosis Research Committee.
2013 - present Co-Chair of Pediatric Assembly Journal Club. American Thoracic Society.
2014 - present Ohio Sickle Cell Advisory Committee.
2014 - present Midwest Society for Pediatric Research.
2014 - present Sigma Xi Scientific Research Society.
2015 - present Spokesperson- Ohio Doctors for Climate Health.
 

Unpublished Works

Kopp BT, Nicholson L, Paul G, Tobias J, Ramanathan C, Hayes D. The geographic impact on hospitalization in patients with cystic fibrosis. May 2015.

Jain A, Harding C, Assani K, Shrestha C, Haga M, Leber A, Munson RS, Kopp BT. Emergence of Acinetobacter pittii recovered from invasive isolates in a pediatric academic center. June 2015.

Assani K, Shrestha C, Robledo F, Partida-Sanchez S, Schlesinger LS, and Kopp B. Human cystic fibrosis macrophages have defective calcium-dependent PKC activation of the NADPH oxidase. January 0.