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Amy Lovett-Racke, PhD


460 W 12th Ave
Columbus, OH 43210

Phone: (614) 688-5647

Email: lovett-racke.1@osu.edu

 

Current OSU Appointments

Professor, SBS-Microbial Infectn/Immunity

Professor, SBS-Neuroscience

 

Advising Narrative

AMANDA SELHORST
Amanda is currently a graduate student at Ohio Dominican University pursuing a Master’s degree in Physician Assistant Studies. She was in the OSU Biomedical Sciences undergraduate program and did an Honors Thesis in my laboratory. Amanda gave an oral presentation at the OSU Medical Center Research Day Program in 2015 and she received 2nd place in Biological Sciences for her presentation at the Denman Undergraduate Research Forum in 2014. She is co-first author on a manuscript in preparation that describes how vitamin D signaling in neurons may be critical for minimizing central nervous system inflammation and protecting individuals from multiple sclerosis.

NICHOLAS JARJOUR
Nicholas is currently a graduate student at Washington University in St. Louis, MO, seeking a PhD in Immunology. He was in the OSU Biomedical Sciences undergraduate program and did an Honors Thesis in my laboratory. Nicholas received Honorable Mention for his presentation at the Denman Undergraduate Research Forum in 2013. He also recognized with several awards during his time in my laboratory, including National Science Foundation Graduate Research Fellowship Honorable Mention (2013-2014), OSU Honors Collegium Distinguished Senior Award (2013), Sigma Xi Associate Member (2012), and Barry M. Goldwater Scholarship Honorable Mention (2011-2012).

Noteworthy Graduate Narrative

MARY SEVERIN
Mary will receive her PhD in Dec 2015. Some of her accomplishments are below.
-Awards and Honors
2015 &emsp&emspAmerican Association of Immunologists Trainee Abstract Award
2015 &emsp&emspAmerican Association for the Advancement of Science (AAAS)/ScienceProgram for Excellence in Science Sponsored Membership
2014 &emsp&emspCenter for Microbial Interface Biology Travel Grant
2014 &emsp&emspHayes Forum Honorable Mention
2013 &emsp&emspImmunology Round Table Travel Award
2013 &emsp&emspProcter and Gamble Best Student Speaker Award
2013 &emsp&emspBiomedical Sciences Graduate Program Travel Award
2012 &emsp&emspEdward J. Ray Travel Award for Scholarship and Service
-Leadership
2012-2015 &emspStudent Representative: Professional Development and Mentoring Committee, Department of Microbial Infection and Immunity, OSUMC
2012-2014 &emspPresident: The Microbial Infection and Immunity Graduate Student Society
2012 &emspSocial Chair: SUCCESS Graduate Student Committee, The Summer Undergraduate Course Creating Excellence in Scientific Study, OSUMC
2012 &emsp&emspJudge: Ohio State Science Day, “Future Physician Scientist Award”
2012 &emsp&emspOral Proctor: Edward F. Hayes Graduate Research Forum
-Publications
2015&emspSeverin ME, Lee P, Liu Y, AJ Selhorst, MG Gormley, W. Pei, Y. Yang, Guerau-de-Arellano M, , Racke MK, and Lovett-Racke AE. MiRNAs Targeting TGFβ Signaling Underlie the Treg Defect in Multiple Sclerosis (Submitted to Annals of Neurology).
2014&emspPeine K, Guerau-de-Arellano M, Lee P, Kanthamneni N, Severin ME, Probst D, Peng H, Yang Y, Vangundy Z, Papenfuss T, Lovett-Racke AE, Bachelder E, and Ainslie K. Treatment of Experimental Autoimmune Encephalomyelitis by Co-Delivery of Disease Associated Peptide and Dexamethasone in Acetalated Dextran Microparticles. Mol Pharm11:828.
National and International Presentations
2015 &emspAmerican Association of Immunologists Annual Meeting. New Orleans, LA.
2014 &emsp12th International Congress of Neuroimmunology, Mainz, Germany.
2014 &emspAmerican Association of Immunologists Annual Meeting, Pittsburgh, PA.

PRISCILLA LEE
Priscilla will receive her PhD in Dec 2015. Some of her accomplishments are below.
-Awards and Honors
2015&emspOutstanding presentation award in The OSU Molecular Life Science Interdisciplinary Graduate Programs Symposium
2015&emsp&emspThe American Association of Immunologists Trainee Abstract Award
2014&emsp&emspThe American Association of Immunologists Trainee Poster Award
2014&emspSelected for an oral presentation in OSU Center of Microbial Interface Biology Symposium
2013&emsp1st place in poster competition in The OSU Molecular Life Science Interdisciplinary Graduate Programs Symposium
2013&emsp&emspSelected to participate in the Edward Hayes Graduate Research Forum ‐ 1st Place in the poster competition for Biological Sciences&emsp
2012-2014&emspNIH CTSA TL1 Fellowship - Specialization in Biomedical Clinical and Translational Science, Center of Clinical Translational Science, OSU
2012&emspSelected to participate in the Edward Hayes Graduate Research Forum&emsp
-Publications
2015&emspLee PW, Yang Y, Racke MK and Lovett-Racke A.E. Analysis of TGF-β1 and TGF-β3 as Regulators of Encephalitogenic Th17 Cells: Implications for Multiple Sclerosis. Brain Behav Immunity 46:44.
2015&emspYang Y, Winger RC, Lee PW, Nuro-Gyina PK, Minc A, Larson M, Liu Y, Pei W, Rieser E, Racke MK, Lovett-Racke AE. Impact of suppressing retinoic acid-related receptor gamma t (ROR)γt in ameliorating central nervous system autoimmunity. Clin Exp Immunol. 179:108.
2014&emspPeine KJ. Guerau-de-Arellano M, Lee PW, Kanthamneni N, Severin M, Probst GD, Peng H, Yang Y, Vangundy Z, Papenfuss TL, Lovett-Racke AE, Bachelder EM, Ainslie KM. Treatment of experimental autoimmune encephalomyelitis by codelivery of disease associated peptide and dexamethasone in acetalated dextran microparticles. Mol Pharm. 11:828.
-National and International Presentations
2015&emsp102th the American Association of Immunologists meeting (New Orleans, LA ).
2014&emsp12th International Congress of Neuroimmunology (Mainz, Germany).
2014&emsp101th the American Association of Immunologists (Pittsburg, PA).
2013&emspNational Clinical and Translational Sciences Predoctoral Programs Meeting (Rochester, MN).
2012&emsp11th International Congress of Neuroimmunology (Boston, MA).

DAVID HUSS, PHD
David is currently a Scientist II, running an independent laboratory at Biogen. Some of his accomplishments during graduate school are below.
-Awards and Honors
2010&emspAward winner for oral presentation at the OSU Molecular Life Sciences Interdisciplinary Graduate Program Symposium.
2009-2011&emspNIH TL1 Fellowship – Center for Clinical and Translational Science, OSU.
-Publications
2012&emspPeng H, M Guerau, VB Mehta, DJ Huss, TL Papenfuss, AE Lovett-Racke, and MK Racke. Dimethyl fumarate inhibits dendritic cell maturation via Nuclear Factor κB (NF-κB) and Extracellular Signal-related kinase 1 and 2 (ERK1/2) and Mitogen Stress activated kinase 1 (MSK1) signaling. J Biol Chem 10;287:28017.
2011&emspHuss DJ, RC Winger, Y Yang, M Guerau, MK Racke, AE Lovett Racke. TGF-β signaling via smad4 drives IL-10 production in effector Th1 cells and reduces host cell recruitment in EAE. Eur J Immunol 41:2987.
2010&emspHuss DJ, RC Winger, H Peng, Y Yang, MK Racke and AE. Lovett-Racke. TGF-β enhances effector Th1 cell activation but promotes self-regulation via IL-10. J Immunol 184:5628.
2010&emspPeng H. and DJ Huss. A novel role for Kv1.3 blockers: protecting neural progenitor cells from a hostile inflammatory environment. J Neurosci 30(32):10609.
2009&emspYang Y, J Weiner, Y Liu, AJ Smith, DJ Huss, R Winger, H Peng, PD Cravens, MK Racke and AE&emspLovett-Racke. T-bet is essential for encephalitogenicity of both Th1 and Th17 cells. J Exp Med 206:1549.
-National and International Presentations
2010&emsp10th International Congress of Neuroimmunology: Barcelona, Spain.

ALAN J. SMITH, MD/PHD
-Awards and Honors
2010&emspNIH TL1 Fellowship – Center for Clinical and Translational Science, The Ohio State University, Columbus, OH
2009&emspMD/PhD Scientific Achievement Travel Award, The Ohio State University, Columbus, OH
-Publications
2011&emspSmith AJ, Liu Y, Peng H, Beers R, Racke MK, Lovett-Racke AE. Comparison of a Classical Th1 Bacteria Versus a Th17 Bacteria as Adjuvant in the Induction of Experimental Autoimmune Encephalomyelitis. J Neuroimmunol 237:33-8.
2009&emspYang Y, Weiner J, Liu Y, Smith AJ, Huss DJ, Winger R, Peng H, Cravens PD, Racke MK, Lovett-Racke AE. T-bet is Essential for Encephalitogenicity of Both Th1 and Th17 Cells. J Exp Med 206:1549.
-National and International Conference Presentations
2008&emsp&emsp9th International Congress of Neuroimmunology, Fort Worth, TX.

ANNE ROCCHINI GOCKE, PHD
Anne is currently an Assistant Professor at John Hopkins University. Some of her accomplishments during graduate school are below.
-National and International Presentations
2006&emsp&emsp8th International Congress of Neuroimmunology, Nagoya, Japan.
2006&emsp&emspCold Spring Harbor Conference, Cold Springs, NY.
2004&emsp&emsp7th International Congress of Neuroimmunology, Venice, Italy.
-Publications
2011&emspGhoreschi K, Weigert C, Deng C, Bruck J, Hussain RZ, Gocke AR, Respa A, Valtcheva N, Feil S, Feil R, Rupec RA, Lovett-Racke AE, Dringen R, Racke MK and Rocken M. Fumarates improve psoriasis and multiple sclerosis by inducing type II dendritic cells. J Exp Med 208:2291.
2010&emspHu W, Nessler S, Hemmer B, Eagar TN, Kane LP, Leliveld SR, Müller-Schiffmann A, Gocke AR, Lovett-Racke A, Ben L, Hussain R, Breil A, Elliott JL, Puthaparthi K, Cravens PD, Singh MP, Petsch B, Stitz L, Racke MK, Korth C and Stüve O. Pharmacological PrP-silencing accelerates CNS autoimmune disease via TCR signaling. Brain 133:375.
2010&emspYang Y, Liu Y, Wei P, Peng H, Winger R, Hussain RZ, Ben L., Cravens PD, Gocke AR, Puttaparthi K, Racke MK, McTigue DM and Lovett-Racke AE. Silencing Nogo-A promotes functional recovery in demyelinating disease. Ann Neurol 67:498.
2009&emspGocke AR, Hussain RZ. Ben L, Drew PD, Lovett-Racke AE and Racke MK. Transcription modulation of the immune response by PPARα agonists amerliorates autoimmune encephomyelitis. J Immunol 182:4479.
2008&emspYang Y, Gocke AR, Lovett-Racke AE, Drew PD and Racke MK. PPAR regulation of the immune response and autoimmune encephalomyelitis. PPAR Research 2008:546753.
2007&emspGocke AR, Northrop SC, Ben L, Hussain RZ, Cravens PD, Racke MK and Lovett-Racke AE. T-bet regulates the fate of TH1 and TH17 lymphocytes in autoimmunity. J Immunol 178:1341.
2006&emspRacke MK, Gocke AR, Muir M, Diab A, Drew PD and Lovett-Racke AE. Nuclear receptors and autoimmune disease: The potential of PPAR agonists to treat multiple sclerosis. J Nutrition 136:700.
2005&emspLovett-Racke AE, Cravens PD, Gocke AR, Racke MK and Stuve O. Therapeutic potential of small interfering RNA for central nervous system diseases. Arch Neurol 62:1810.
2004&emspLovett-Racke AE, Rocchini AE, Choy J, Northrop SC, Hussain RZ, Sikder D and Racke MK. Silencing T-bet defines a critical role in the differentiation of autoreactive T lymphocytes. Immunity 21:719.

Research Funding

I have been continuously funded since 1999, the year in which I became faculty at UT Southwestern. Since joining the OSU faculty in 2006, I have been the principal investigator on 7 grants, 3 funded by the NIH, 3 funded by the National Multiple Sclerosis Society and one funded by the Strategic Pharma-Academic Research Consortium. In addition, I have been co-investigator on 8 additional grants. Thus, I have been able to contribute significantly to MS research, and I have also be able to provide significant support to my own salary, including some years in which I was supported 100% by grants.

Academic Advising

I have had the opportunity to work with numerous young people in various stages of their education and career, and advise them on opportunities and assist them with pursuing their goals. As a faculty member in three graduate programs, graduate students from all of these programs have performed rotations in my laboratory and I have assisted them in identifying laboratories for their dissertation research. Since there are relatively few immunologists in the College of Medicine, I have also had the opportunity to advise several students in other laboratories on their research projects that has been very successful for broadening opportunities for students, as well as forging collaborations between laboratories. I also assist graduate students with preparation for their Oral Candidacy Exam. I have developed core concepts to assist students with fundamental skills necessary to be successful during oral exams. Several individuals have also joined my laboratory for the purpose of gaining insight into medical research and academic medicine, enabling them to make well-informed decisions on pursuing a career in medicine and/or research. As a working mother of 6 children, I have also been a source for graduate students with children or planning to have children to discuss issues about the feasibility of have a research career and managing a demanding family life. In addition to one-on-one conversations with students, I have participated in panel discussions on managing personal and professional lives.

Academic Advising

2011 Priscilla Lee, The Ohio State University. Graduated 0. Defining the Minimal Signals Required to Generate Encephalitogenic T Cells
2011 Mary Severin, The Ohio State University. Graduated 0. MicroRNAs Underlie the Treg Defect in Multiple Sclerosis
2015 Vikas Pulluru, The Ohio State University. Graduated 0.
2015 Giancarlo Valiente, The Ohio State University. Graduated 0.
2015 Matthew Xin, The Ohio State University. Graduated 0.
2015 Phyllis Donkor, The Ohio State University. Graduated 0.
2015 Varun Shah, The Ohio State University. Graduated 0.
2009 - 2010 Fatemeh Talebian, The Ohio State University. Graduated 2012. CD200-CD200R Interaction in Tumor Immunity
2009 - 2010 Ekaterina Karelina, The Ohio State University. Graduated 2010. Mechanisms of Social Neuroprotection after Cerebral Ischemia
2009 - 2010 Naveen Kanthamneni, The Ohio State University. Graduated 2012. Development of Immunosupressant and Peptide Loaded Microparticles as Tolerogenic Vaccines for Treatment of Autoimmune Diseases
2010 W. Hans, The Ohio State University. Graduated 2015. Improving Oncolytic Viral Therapy for Brain Tumors
2010 Amanda Roloson, The Ohio State University. Graduated 0.
2006 - 2011 Yuhong Yang, The Ohio State University. Graduated 0.
2010 - 2011 Ashley Fenn, The Ohio State University. Graduated 2014. Mechanisms and Consequences of Microglial Priming and Dysregulated M2a Responses with Age and Central Nervous System Injury
2011 Christie McCracken, The Ohio State University. Graduated 2015. Toxicity of Food-Relevant Nanoparticles in Intestinal Epithelial Models
2010 - 2012 Fatemeh Talebian, The Ohio State University. Graduated 2012. CD200-CD200R Interaction in Tumor Immunity
2011 - 2012 Sara McMaken, The Ohio State University. Graduated 0.
2011 - 2013 Kevin Peine, The Ohio State University. Graduated 2014. Formulation of Particulate-based Immunomodulatory Therapeutics for the Treatment of Diseases
2012 - 2013 Bryan Brautigam, The Ohio State University. Graduated 2013. Examining the Regulation of Inflammation through CD200 and CD200R Following Spinal Cord Injury
2012 - 2013 Nicholas Jarjour, The Ohio State University. Graduated 2013.
2012 - 2013 Matthew Koerbel, The Ohio State University. Graduated 2014.
2011 - 2014 Ashley Fenn, The Ohio State University. Graduated 2014. Mechanisms and Consequences of Microglial Priming and Dysregulated M2a Responses with Age and Central Nervous System Injury
2013 - 2014 Ying-Chin Wang, The Ohio State University. Graduated 2014. Using Red Blood Cells in Microbial Fuel Cell Catholyte Solution to Improve Electricity Generation
2013 - 2014 Kevin Peine, The Ohio State University. Graduated 2014. Formulation of Particulate-based Immunomodulatory Therapeutics for the Treatment of Diseases
2013 - 2014 Patrick Nuro-Gyina, The Ohio State University. Graduated 0.
2014 Christina Sabin, The Ohio State University. Graduated 0.
2014 Patrick Nuro-Gyina, The Ohio State University. Graduated 0.
2013 - 2015 Amanda Selhorst, The Ohio State University. Graduated 2015. Defining the Role of Vitamin D in Multiple Sclerosis
2014 - 2015 Varun Shah, The Ohio State University. Graduated 0.
 

Chapters in Books

Role of nerve growth factor in experimental autoimmune encephalomyelitis

Experimental autoimmune encephalomyelitis (EAE).

The role of costimulation in experimental autoimmune encephalomyelitis

The Basics of Cellular and Molecular Immunology

Therapeutic potential of small interfering RNA for brain diseases

Role of IL-12/IL-23 in the Pathogenesis of Multiple Sclerosis

T-bet as a Key Transcription Factor in Autoimmune Inflammatory Demyelination

 

Degrees

1987 B.S., Texas A&M University

1993 Ph.D., The University of Texas Health Science Center at Houston

 

Editorial Activities

2004 - present Journal of Leukocyte Biology
2005 - present Acta Pharmacologica Sinica
2005 - present Journal of Neuroimmunology
2007 - present Proceedings of the National Academy of Science
2007 Arthritis and Rheumatism
2008 - present PPAR Research
2008 - present Journal of Immunology
2008 - present Immunobiology
2009 - present Brain, Behavior and Immunity
2009 - present European Journal of Immunology
2010 - present Frontiers in Neurology: Multiple Sclerosis and Neuroimmunology
2010 - present Journal of Neuroimmunology
2010 - present Annals of Neurology
2011 - present Brain
2011 Nature
2011 - 2015 Journal of Immunology
2012 - present PLoS One
2014 - present Brain, Behavior and Immunity
2014 - present Clinical Immunology
2014 Frontiers in Immunology
 

Honors

1993 - 1995 Intramural Research Training Award. National Institutes of Neurological Disorders and Stroke.
1995 - 1997 Lucille P. Markey Special Emphasis Pathway in Human Pathobiology. Lucille P. Markey Foundation.
2004 - 2009 Harry Weaver Neuroscience Scholar. National Multiple Sclerosis Society.
2010 - present Excellence in Teaching. College of Medicine Med I/II Integrated Pathway Program.
2013 College of Medicine Distinguished Educator Award. OSU College of Medicine.
2014 - present Multiple Sclerosis Research Hall of Fame. National Multiple Sclerosis Society.
 

Journal Articles

 

Reference Works

January 1992 Lovett A, McCarthy M, Frey T, Rice C, Wolinsky JS."Rubella-specific cytotoxic T-cell responses" . : A1334
January 1998 Lovett-Racke A, Trotter J, Lauber J, Perrin P, June C and Racke M."Decreased dependence of myelin basic protein-reative T cells on CD28-mediated costimulation in multiple sclerosis patients" . : 75
January 1998 Lovett-Racke A, Bittner P, Cross A, Carlino J and Racke M."Regulation of experimental autoimmune encephalomyelitis with insulin-like growth factor (IGF-1) and IGF-1/IGF binding protein-3 complex" . : 60
January 1998 Racke MK, Trotter JL, Perrin PJ, June CH, Lovett-Racke AE."Decreased dependence of myelin basic protein-specific T cells on CD28-mediated costimulation in multiple sclerosis patients" . : A358
January 1998 Segal BM, Willenborg DO, Racke MK, Lovett-Racke AE, Hoffman LM, Karpus WJ, Begolka WS, Miller SD."Immune cell entry to the CNS - a focus for immunoregulation of EAE - Discussion" . : 844-846
January 1998 Owens T, Segal BM, Racke MK, Lovett-Racke AE, Begolka WS, Miller SD."Tumour necrosis factor-alpha and lymphotoxin-alpha in the pathology of experimental autoimmune encephalomyelitis: is either one responsible or is there another ligand-mediated disease? Discussion" . : 849-850
January 1998 Willenborg DO, Racke MK, Lovett-Racke AE, Hoffman LM, Karpus WJ, Owens T."Cytokines as intrinsic and exogenous regulators of pathogenesis in experimental encephalomyelitis - Discussion" . : 843-844
January 1998 Begolka WS, Miller SD, Segal BM, Racke MK, Lovett-Racke AE."Antigen-driven regulation of experimental autoimmune encephalomyelitis - Discussion" . : 842-843
January 2001 Deng C, Hussain R, Lovett-Racke AE, Rocken M and Racke MK."Monomethylfumarate induces a Th2 immune response and suppresses experimental autoimmune encephalomyelitis" . : 96
January 2001 Lovett-Racke AE, Diab A, Deng C, Hussain R, Smith J and Racke MK."Th2 cytokine expression in the developing central nervous system" . : 101
January 2001 Ratts RB, Karandikar NJ, Lovett-Racke AE, Monson NL, Smith JD and Racke MK."An increased immune response to glatiramer acetate is short lived and may not explain its long-term therapeutic benefit in treated multiple sclerosis patients" . : 137
January 2001 Deng CS, Hussain R, Lovett-Racke A, Radu C, Minguela A, Ward S, Racke M."The tyrosine phosphatase SHP-1 deficiency enhances the T cell response and exacerbates experimental autoimmune encephalomyelitis" . : A1060
January 2002 Ghoreschi K, Deng C, Hussain RZ, Viale O, Reitmeier C, Lovett-Racke AE, Racke MK and Rocken M."Abrogating the pathogenicity of autoreactive T cells with anti-psoriatic agents" . : 8
January 2002 Ghoreschi K, Deng C, Hussain RZ, Reitmeier C, Lovett-Racke A, Racke MK, Rocken M."Therapeutic immune deviation abrogates pathogenicity of autoreactive T cells" . : 319
January 2002 Karandikar NJ, Crawford MP, Yan X, Ratts RB, Brenchley JM, Lovett-Racke AE, Douek DC, Koup RA, Racke MK."Induction and restoration of CD8+ T cell responses following glatiramer acetate (Copaxone) therapy in multiple sclerosis" . : S90
January 2002 Karandikar NJ, Crawford MP, Ratts RB, Brenchley JM, Ambrozak DR, Lovett-Racke AE, Douek DC, Koup RA, Racke MK."Treatment with glatiramer acetate (GA) induced and restores CD8+ T-cell responses in patients with multiple sclerosis" . : A246
January 2002 Karandikar NJ, Crawford MP, Ratts RB, Brenchley JM, Ambrozak DR, Lovett-Racke AE, Douek DC, Koup RA, Racke MK."Treatment with glatiramer acetate (GA; Copaxone) induces and restores CD8+ T-cell responses in patients with multiple sclerosis" . : A1046-A1047
January 2004 Rocchini AE, Choy J, Northrop SC, Hussain RZ, Sikder D, Racke MK and Lovett-Racke AE."The role of T-bet in the differentiation of encephalitogenic T cells" . : 62
January 2004 Hansen B, Lovett-Racke AE, Hussain RZ, Northrop SC and Racke MK."The role of toll-like receptors in the pathogenesis of EAE" . : 57
January 2004 Lovett-Racke AE, Rocchini AE, Choy J, Northrop SC, Hussain RZ and Racke MK."Silencing T-bet prevents autoimmune demyelinating disease" . : 52
January 2004 Ratts R, Lovett-Racke A, Karandikar N and Racke MK."Characterization of chronically stimulated T cells in humans" . : 216
January 2006 Cravens PD, Gocke AR, Northrop SC, Ben L, Hussain RZ, Racke MK and Lovett-Racke AE."The role of T-bet in the regulation of inflammation in the CNS" . : 64
January 2006 Gocke AR, Hussain RZ, Ben L, Lovett-Racke AE and Racke MK."Transcription modulation of the immune response by PPARalpha agonists ameliorates EAE" . : 164
January 2008 Harp C, Lovett-Racke A, Racke M, Frohman E and Monson N."B-T cell interactions in multiple sclerosis" . : 139
January 2008 Lovett-Racke AE, Gocke AR, Yang Y, Hussain R, Liu Y, Ben L, Cravens P and Racke MK."Role of T-bet in regulating autoimmune Th1 and Th17 cells" . : 158
January 2008 Yang Y, Weiner J, Liu Y, Racke M and Lovett-Racke A."Defining autoreactive encephalitogenic T cells" . : 234
January 2008 Smith AJ, Yang Y, Weiner J, Racke MK and Lovett-Racke AE."Defining the role of IL-23 in the differentiation of encephalitogenic T cells" . : 239
January 2009 Hu W, Nessler S, Hemmer B, Eagar T, Kane L, Leliveld R, Muller-Schiffmann A, Gocke A, Lovett-Racke A, Ben LH, Hussain R, Breil A, Elliott J, Carson P, Cravens P, Singh M, Petsch B, Stitz L, Racke M, Korth C, Stuve O."Prior Protein is a key regulator of T cell activation, differentiation and survival" . : A280-A281
January 2009 Racke M, Yang Y, Liu Y, Smith A, Winger R, Peng H, Cravens P, Lovett-Racke A."T-bet, not cytokine expression, determines T-cell encephalitogenicity" . : S59-S60
November 2010 Smith K, Guerau-de-Arellano M, Bottoni A, et al."MicroRNAs Modulate Immune Function in Multiple Sclerosis" . : 121-122
October 2010 Huss D, Winger R, Peng H,."TGF-beta enhances Th1 cell activation yet reduces EAE disease course by promoting T cell self-regulation" . : 140
November 2010 Peng H, Akyol E, Guerau M, et al."The dual function of Dimethyl Fumarate in Multiple Sclerosis" . : 98
March 2011 Racke MK, Peng HY, Akyol E, Lovett-Racke AE, and Pitt D."Neuroprotective Potential of Fumaric Acid Esters in a Model of Multiple Sclerosis" . : A385-A386
December 2012 Peng HY, Guerau-de-Arellano M, Mehta V, Yang YH, Huss D, Papenfuss T, Lovett-Racke A, and Racke M."Dimethyl Fumarate Inhibits Dendritic Cell Maturation via NF-kB and ERK1/2-MSK1 Signaling" . : 174-175
January 2012 ."" .
December 2012 Lee P, Yang Y, and Lovett-Racke A."Defining the Minimal Signals Necessary to Generate an Encephalitogenic T Cell" . : 72
September 2012 Peng HY, Akyol E, Pitt D, Lovett-Racke A, and Racke M."Dimethyl Fumarate Protects the CNS Against Excitotoxicity" . : S7
May 2013 Zhang GX, Yan YP, Ding XL, Li K, Ciric B, Yang JX, Wu S, Xu H, Chen WJ, Lovett-Racke A, and Rostami A."IFN-gamma Signaling in Astrocytes and Microglia has Opposite Roles in CNS Autoimmunity" .
May 2013 Guerau-de-Arellano M, Lovett-Racke A and Racke M."T Cell miRNA in Multiple Sclerosis Pathogenesis" .
October 2014 Lee P, Smith A, Yang Y, Selhorst A, Racke M and Lovett-Racke A."Critical Contribution from Antigen Presenting Cells for Encephalitogenic T Cells" . : 65-66
October 2014 Severin M, Guerau-de-Arellano M, Lee P, Racke M, and Lovett-Racke A."Differentially Expressed MicroRNAs in Multiple Sclerosis Patients Alter Regulatory T Cells" . : 112-113

Presentations

Immune Deviation as a Potential Therapy for Multiple Sclerosis

Immune Mechanisms and Autoimmune Injury

Immune Mechanisms and Autoimmune Injury

Therapeutic Potential of Gene Silencing in Immune-mediated Demyelinating Disease

Development of New Therapeutic Agents for Multiple Sclerosis

Therapeutic Potential of siRNA for the Treatment of Multiple Sclerosis

Therapeutic Potential of siRNA for Multiple Sclerosis

Therapeutic Benefit of Silencing T-bet in Autoimmune Demyelinating Disease

Therapeutic Potential of siRNA for Multiple Sclerosis

Multiple Sclerosis

Role of T-bet in Autoreactive Th1 and Th17 Cells

Identifying Therapeutic Targets for Multiple Sclerosis

Identifying Therapeutic Targets for Multiple Sclerosis

Defining the Role of T-bet in Encephalitogenic Th1 and Th17 Cells

Silencing T-bet Suppresses Th1 and Th17 Cell Differentiation

Role of T-bet in Regulating Autoimmune Th1 and Th1 Cells

T-bet or not T-bet, that is the question (in autoimmunity)

Experimental Autoimmune Encephalomyelitis: A Model of Multiple Sclerosis

Identifying microRNA Differentially Expressed in T Cells of MS Patients

T-bet or not T-bet: That is the Question in Autoimmunity

Therapeutic Potential of Small RNAs in Multiple Sclerosis

Multiple Sclerosis

Small RNAs...Big Results: Potential Roles of siRNA and miRNA in Multiple Sclerosis

Defining the Role of miRNA in Susceptibility to Multiple Sclerosis

Small RNAs: Susceptibility Factors and Potential Therapies for Multiple Sclerosis

Small RNAs...Big Results: Potential Roles of siRNA and miRNA in Multiple Sclerosis

Potential of Small Interfering RNAs as Therapies for Multiple Sclerosis

Role of miRNA in T Cells in Susceptibility to Multiple Sclerosis

Molecular Characterization of Pathogenic T Cells in Multiple Sclerosis

Road to PI

Development of Small RNA-Based Therapies for Multiple Sclerosis

Are miRNAs Susceptibility Factors for Multiple Sclerosis

Are miRNAs Susceptibility Factors for Multiple Sclerosis?

Small RNAs...Big Results: Potential Roles of siRNA and miRNA in Multiple Sclerosis

Contribution of EAE to understanding and treating multiple sclerosis

Silencing T-bet prevents autoimmune demyelinating disease

 

Professional Activities

present Challenge Grants. National Institutes of Neurological Disorders and Stroke.
present Neuroscience Training Study Section - Ad hoc member. National Institutes of Health.
present Autoimmunity Center of Excellence Study Section - Ad hoc member. National Institutes of Health.
present Immunology Fellowship and Academic Research Enhancement Award Study Section - Ad hoc member. National Institutes of Health.
2015 - present Hypersensitivity Autoimmune and Immune-mediated Diseases Study Section - Permanent Member. National Institutes of Health.
2015 - present Chair - Immunology Pilot Project Committee. National Multiple Sclerosis Society.
- 2005 Ad-hoc. Medical Research Council.
- 2006 Clinical Neuroimmunology and Brain Tumor Study Section Ad-hoc. National Institutes of Neurological Disorders and Stroke.
2004 - 2008 Pilot Project. National Multiple Sclerosis Society.
2009 - 2014 Advisory Committee Member. National Multiple Sclerosis Society.
 

Unpublished Works

MiRNAs Targeting TGFbeta signaling Underlie the Treg Defect in Multiple Sclerosis

IL-23R-activated STAT3/STAT4 Signaling is Essential for Th1 and Th17 Cell-mediated Neuroinflammation

Molecular Profiles Unique to Encephalitogenic T Cells in Multiple Sclerosis

Vitamin D Signaling on Neurons During Early Life Promotes CNS Homeostasis and Decreases Susceptibility of Developing Autoimmune Encephalomyelitis