Janies, Daniel

Daniel Janies, PhD
Assistant Professor
3184 Graves Hall
333 W 10th Avenue
Columbus, OH 43210

phone: (614) 292-1202
fax: (614) 688-6600
email:
Daniel.Janies@osumc.edu


Dr Janies received a B.S. in Biology from the University of Michigan, Ann Arbor, and a Ph.D. in Zoology from the University of Florida, Gainsville. He was a NASA Principal Investigator at the American Museum of Natural History, where previously he had been a Postdoctoral Fellow. Since 2003, Dr Janies has been an Assistant Professor at BMI.

Dr. Janies was trained as a biologist, however, as a result of the computational demands of the biological questions he was interested in, he began to develop hardware and software. He led the design, construction, and integration of the parallel computing cluster at the American Museum of Natural History. Using off-the-shelf PC components and relying solely on house talent, his team built an inexpensive, internationally ranked 860-processor supercomputer

Research
My research objectives are to continue to develop computational and evolutionary sciences in a comparative genomics context. I have collaborations with phamacogenomicists and microbiologists. To these ends, I have developed novel phylogenetic methods to correlate genotypes and phenotypes and find diagnostic polymorphisms among organisms. In short, I am mining datasets of mutational history implied by phylogenetic trees for two types of information: 1) recurrent changes in phenotype and genotype among lineages to identify disease candidate genes for complex disease and 2) exclusive changes that are vital to design sensitive reagents such a taxon specific oligonucleotides useful in diagnostics.

Genomics promises a new paradigm for scientific and medical research. Soon we will understand the fundamentals of cellular metabolism, development, and evolution at a basic informational level. This understanding will help us attack the mechanics of the disease rather than treat its symptoms. However having a single genome sequence provides little information by itself. It is through sequence alignment and tree search that one can identify functional regions of bimolecular sequences, diagnose affected from unaffected individuals, and better understand infectious disease. Similarity search is vital to database retrieval, annotation, and gene discovery. Comparative organismal approaches lead to the discovery of the shared functional regions. Thus the field of sequence comparison has much to offer for all fields of modern biology and medicine. Progress requires the synergistic development of software and hardware suited to very large datasets.

Select Publications
Daniel A. Janies, "Genome Technology cover & article for Dan Janies & team, July/Aug. 2007", 2007.

Daniel A. Janies, Andrew Hill, Rob Guralnick, Farhat Habib, Eric Waltari, Ward C. Wheeler, "Genomic Analysis and Geographic Visualization of the Spread of Avian Influenza (H5N1)", Systematic Biology, 2007: pp. 321-329.

Steven L. Salzberg, Carl Kingsford, Giovanni Cattoli, David J. Spiro, Daniel A. Janies, Mona Mehrez Aly, Ian Brown, Emmanuel Couacy-Hymann, Gian Mario De Mia, Do Huu Dung, Annalisa Guercio, Tony Joannis, Ali Safar Maken Ali, Azizullah Osmani, Iolanda Padalino, Magdi D. Saad, Vladamir Savic, Naomi A. Sengamalay, Samuel Yingst, Jennifer Zaborsky, Olga Zorman-Rojs, Elodie Ghedin, IIaria Capua, "Genome Analysis Linking Recent European and African Influenza (H5N1) Viruses", 2007.

Farhat Habib, Andrew Johnson, Ralf Bundschuh, Daniel A. Janies, "Large scale genotype-phenotype correlation analysis based on phylogenetic trees", Bioinformatics, 2007: pp. 785-788.

Ward C. Wheeler, Lone Aagesen, Claudia P. Arango, Julian Faivovich, Taran Grant, Cyrille D'Haese, Daniel A. Janies, William L. Smith, Andres Varon, Gonzalo Giribet, "Dynamic Homology and Phylogenetic Systematics: A Unified Approach Using POY", 2006.

X. Zhang, M. Hasoksuz, D. Spiro, R. Halpin, S. Wang, S. Stollar, Daniel A. Janies, N. Hadya, Y. Tang, E. Ghedin, Linda J. Saif, "Complete genomic sequences, a key residue in the spike protein and deletions in nonstructural protein 3b of US strains of the virulent and attenuated coronaviruses, transmissible gastroenteritis virus and porcine respiratory coronavirus.", Virology, 2006: pp. 424-435.

Tahsin M. Kurc, Daniel A. Janies, Andrew Johnson, Stephen Langella, Scott Oster, Shannon L. Hastings, Farhat Habib, Terry Camerlengo, David W. Ervin, Umit V. Catalyurek, Joel H. Saltz, "An XML-based System for Synthesis of Data from Disparate Databases", Journal of the American Medical Informatics Association, 2006: pp. 289-301.

Daniel A. Janies, Linda J. Saif, "Genetic Diversity and Recombination of Porcine Sapoviruses", Journal of Clincal Microbiology, 2005: pp. 5963-72.

Ward C. Wheeler, Ward C. Wheeler, Lone Aagesen, Claudia P. Arango, Claudia P. Arango, Julian Faivovich, Julian Faivovich, Taran Grant, Taran Grant, Cyrille D'Haese, Cyrille D'Haese, Daniel A. Janies, Daniel A. Janies, William L. Smith, William L. Smith, Andres Varon, Andres Varon, Gonzalo Giribet, Gonzalo Giribet, "", 2005.