Bailey, Michael

Michael Bailey, PhD
Oral Biology
2159 Postle Hall
305 W. 12th Ave.
Columbus, OH 43210
Office Phone: (614)247-2301
Lab Phone: (614)292-2012
Fax: (614)247-6945
bailey.494@osu.edu

Research Interests: 
Innate Immunity, Inflammation, Psychoneuroimmunology,  Microbial Flora, Microbial Infection, Psychoneuroendocrinology, Psychobiology

Research Summary: 
Stress is well known to suppress many aspects of immunity, and many of the mechanisms through which this occurs have been clearly defined.  However, stress can also have no effect on immune functioning or it can actually enhance immune functioning.  Despite this knowledge, relatively little research has focused on the mechanisms through which stress enhances the immune response.  Moreover, it is not known whether stress-induced increases in the immune response would be beneficial or detrimental during microbial infection.  For example, stress-induced increases in the inflammatory response to oral pathogens could be one reason why oral inflammatory diseases, such as gingivitis and periodontitis, are often exacerbated during periods of psychological stress.

Research in this laboratory is focused on 1. defining the characteristics of stressors that cause them to be immunosuppressive vs. immunoenhancive 2. defining the endocrine and cellular mechanisms through which these stressors can affect immunity (with a particular focus on macrophage anti-microbial immunity) and 3. determining whether this increased immunity is adaptive or maladaptive during a microbial challenge.

Published Papers:
Kinsey SG, Bailey MT, Padgett DA, Sheridan JF, and Avitsur R.  Repeated social defeat causes increased anxiety-like behavior and alters splenocyte function in C57BL/6 and CD-1 mice.  Brain Behav Immun In Press

Bailey MT, Engler H, and Sheridan JF. Stress induces the translocation of cutaneous and gastrointestinal microflora to secondary lymphoid organs of C57BL/6 mice. J Neuroimmunol 171: 29-37, 2006.

Engler H, Engler A, Bailey MT, and Sheridan JF. Tissue-specific alterations in the glucocorticoid sensitivity of immune cells following repeated social defeat in mice. J Neuroimmunol 163: 110-119, 2005.

Bailey MT, Avitsur R, Engler H, Padgett DA, and Sheridan JF. Physical defeat reduces the sensitivity of murine splenocytes to the suppressive effects of corticosterone. Brain Behav Immun 18: 416-424, 2004.

Engler H, Bailey MT, Engler A, and Sheridan JF. Effects of repeated social stress on leukocyte distribution in bone marrow, peripheral blood and spleen. J Neuroimmunol 148: 106-115, 2004.

Bailey MT, Lubach GR, and Coe CL. Prenatal stress alters bacterial colonization of the gut in infant monkeys. J Pediatr Gastroenterol Nutr 38: 414-421, 2004.

Bailey M, Engler H, Hunzeker J, and Sheridan JF. The hypothalamic-pituitary-adrenal axis and viral infection. Viral Immunol 16: 141-157, 2003.

Bailey MT and Coe CL. Endometriosis is associated with an altered profile of intestinal microflora in female rhesus monkeys. Hum Reprod 17: 1704-1708, 2002.

Bailey MT and Coe CL. Intestinal microbial patterns of the common marmoset and rhesus macaque. Comp Biochem Physiol A Mol Integr Physiol 133: 379-388, 2002.

Bailey MT and Coe CL. Maternal separation disrupts the integrity of the intestinal microflora in infant rhesus monkeys. Dev Psychobiol 35: 146-155, 1999.

Bailey MT, Karaszewski JW, Lubach GR, Coe CL, and Lyte M. In vivo adaptation of attenuated Salmonella typhimurium results in increased growth upon exposure to norepinephrine. Physiol Behav 67: 359-364, 1999.

Lyte M and Bailey MT. Neuroendocrine-bacterial interactions in a neurotoxin-induced model of trauma. J Surg Res 70: 195-201, 1997.

Lyte M, Varcoe JJ, and Bailey MT. Anxiogenic effect of subclinical bacterial infection in mice in the absence of overt immune activation. Physiol Behav 65: 63-68, 1998.


Book Chapters:
M. T. Bailey, D. A. Padgett, and J. F. Sheridan. (2006).  Stress-induced modulation of        innate resistance and adaptive immunity to influenza viral infection.  In R. Ader,          D.L. Felten, and N.  Cohen (Eds.), Psychoneuroimmunology, 4th Edition.             London: Academic, San Diego, CA. 

M. T. Bailey, D. A. Padgett, and J. F. Sheridan. (2006).  Influenza viral infection: Stress-        induced modulation of innate resistance and adaptive immunity.  In Welsh,     Meagher, and Sternberg (Eds.), Neural and Neuroendocrine Mechanisms in Host             Defense and Autoimmunity. Springer Publishers, New York, NY.

D. A. Padgett, M. T. Bailey, and J. F. Sheridan.  (2006).  Herpesviruses.  In   Encyclopedia of Stress, 2nd Edition.  Elsevier, San Diego, CA.